Non-surgical ablative therapies for inoperable benign insulinoma
ConclusionsNon-surgical ablation is a feasible, safe and repeatable procedure in patients with pancreatic insulinoma, who are not candidate to surgery or refuse it. Partial or complete control of symptoms and tumor growth is experienced by the majority of patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 28, 2017 Category: Endocrinology Source Type: research

Gender differences in the association of ELMO1 genetic variants with type 2 diabetes in Tunisian Arabs
ConclusionThese results confirm role forELMO1 as T2DM susceptibility locus, which appears to be gender-dependent. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 27, 2017 Category: Endocrinology Source Type: research

Jusepe de Ribera “Lo Spagnoletto”: Sileno ebbro
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 27, 2017 Category: Endocrinology Source Type: research

Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms
AbstractThe pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance may lead to weight gain; however, results from different study groups are contradictory and indicate a complex interaction between EE and food intake which may differentially influence weight change in humans. Recently, studies evaluating the adaptive response of one component to perturbations of the ...
Source: Journal of Endocrinological Investigation - July 24, 2017 Category: Endocrinology Source Type: research

Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents
ConclusionPPAR γ is decreased in childhood obesity and may be responsible for diminished ANGPTL4 levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 21, 2017 Category: Endocrinology Source Type: research

AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells
ConclusionAT-101 induces apoptosis in mouse pituitary corticotroph tumor cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 20, 2017 Category: Endocrinology Source Type: research

Acquired partial lipodystrophy after bone marrow transplant during childhood: a novel syndrome to be added to the disease classification list
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 18, 2017 Category: Endocrinology Source Type: research

Hyperuricemia is associated with an increased prevalence of paroxysmal atrial fibrillation in patients with type 2 diabetes referred for clinically indicated 24-h Holter monitoring
ConclusionsThis study shows for the first time that hyperuricemia is independently associated with an approximately fourfold increased risk of prevalent paroxysmal AF in patients with T2DM. These findings may partly explain the increased risk of permanent atrial fibrillation and cardiovascular death observed among patients with hyperuricemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 15, 2017 Category: Endocrinology Source Type: research

Does a male polycystic ovarian syndrome equivalent exist?
AbstractThe occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (
Source: Journal of Endocrinological Investigation - July 15, 2017 Category: Endocrinology Source Type: research

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report
AbstractThere is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients with unusual thyroxine needs is to escalate the dose of levothyroxine until targeted TSH levels are achieved. This approach can inc...
Source: Journal of Endocrinological Investigation - July 10, 2017 Category: Endocrinology Source Type: research

Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study
ConclusionsTo our knowledge this is the first study on use of TTG for pubertal activation on CDGP population. Our preliminary data confirm the efficacy of short-term Testosterone gel treatment to induce puberty compared to conventional treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2017 Category: Endocrinology Source Type: research

Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic
ConclusionWe found a frequency of familial PA similar to that previously described, as well as a similar frequency ofAIP mutations among FIPA families. An active search of the affected family members was able to identify one case of Cushing ´s disease. Patients should be aware of pituitary disease’s clinical picture to identify possibly affected family members. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 8, 2017 Category: Endocrinology Source Type: research

Pretransplant diabetes mellitus predicts worse outcomes of liver transplantation: evidence from meta-analysis
ConclusionPreexisting DM predicts worse patient and graft survivals of LT. Concomitant HCV infection would further deteriorate this unfavorable impact. Given the high heterogeneities and the insufficient evidences, more studies are still warranted to support these observations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 30, 2017 Category: Endocrinology Source Type: research

Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors
AbstractPurposeThe incidence of neuroendocrine tumors (NETs) is progressively increasing. Most cases arise from the digestive system, where ileum, rectum and pancreas represent the commonest site of origin. Liver metastases are frequently detected at diagnosis or during the follow-up. Contrast-enhanced ultrasound (CEUS) is used in patients with pancreatic NETs (P-NETs) and liver metastases from P-NET but its role has not been standardized. The aim of this retrospective study was to investigate CEUS in patients with P-NETs and liver metastases from P-NET both as prognostic factor and predictor of response to therapy with so...
Source: Journal of Endocrinological Investigation - June 30, 2017 Category: Endocrinology Source Type: research

The effects of alpha-lipoic acid on diabetic myopathy
ConclusionTreatment with lipoic acid during 4 weeks has shown effects on the redistribution of muscle fibers, and can prevent atrophy in slow and fast diabetic muscle. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options
AbstractWeight gain is a common side effect of many widely used drugs. Weight gain of a few kilograms to an increase of 10% or more of initial body weight has been described. Not only the weight gain as such puts a burden on the health risks of the involved patients, the accompanying increase in the incidence of the metabolic syndrome, type 2 diabetes mellitus, and cardiovascular risk factors urges the caregiver to identify and to closely monitor the patients at risk. In this review, the different classes of drugs with significant weight gaining properties and the metabolic consequences are described. Specific attention is...
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Evaluation of depressive mood and cognitive functions in patients with acromegaly under somatostatin analogue therapy
ConclusionThe present findings show that acromegaly negatively affects learning, attention, and planning. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Action of three bioavailable antioxidants in orbital fibroblasts from patients with Graves ’ orbitopathy (GO): a new frontier for GO treatment?
ConclusionsOur study provides evidence in support of an antioxidant role of vitamin C,N-acetyl-l-cysteine and melatonin in orbital fibroblasts. Some of the effects of these compounds are exclusive to GO fibroblasts, whereas some other are observed also in control fibroblasts. Our observations provide a basis for a possible clinical use of these substances in patients with GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 27, 2017 Category: Endocrinology Source Type: research

Role of Jagged1-Notch pathway in thyroid development
AbstractThe zebrafish thyroid gland shows a unique pattern of growth. Despite the lack of a compact gland, the zebrafish thyroid tissue originates from the pharyngeal endoderm and the main genes involved in its patterning and early development are conserved between zebrafish and mammals. In recent years, the research has been focused to the search of novel candidate genes and environmental factors underlying congenital hypothyroidism. Among these, it has been demonstrated that the Notch signalling plays a central role during zebrafish thyroid development. In this review, we will provide an overview of the current knowledge...
Source: Journal of Endocrinological Investigation - June 26, 2017 Category: Endocrinology Source Type: research

Varicocele and semen quality: a retrospective case –control study of 4230 patients from a single centre
AbstractPurposeThe aim of the present study is to assess impairment of spermatogenesis induced by varicocele in, to our knowledge, the largest single-centre caseload available to date.Materials and methodsWe conducted a retrospective study on 4230 consecutive patients attending our Department for andrological outpatient assessment and preconception check-ups between 2011 and 2014. A total of 2113 patients had varicocele (Group V), while the remaining 2117 were selected as the control group (Group C). All patients were divided into age classes (
Source: Journal of Endocrinological Investigation - June 24, 2017 Category: Endocrinology Source Type: research

The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women
AbstractObjective To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD.DesignWe studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6.4] years). BMD at the lumbar spine, femoral neck (FN), and total hip (TH), body composition; fat mass (FM) and lean mass (LM) as well as abdo...
Source: Journal of Endocrinological Investigation - June 23, 2017 Category: Endocrinology Source Type: research

Latero-cervical lymph node metastases (N1b) represent an additional risk factor for papillary thyroid cancer outcome
AbstractPurposePapillary thyroid carcinoma (PTC), the most common thyroid cancer histotype, has a good prognosis even when spread to the neck lymph node (LN). The prognostic role of LN metastases ’ location is still controversial. The aim of the present study was to evaluate the clinical relevance of the number and location of LN metastases at presentation in PTCs.MethodsThis retrospective study included a consecutive series of 1653 PTC patients followed for a mean period of 5.9  years in a referral thyroid cancer clinic. All patients have undergone thyroidectomy with the dissection of at least six LNs. Accordin...
Source: Journal of Endocrinological Investigation - June 23, 2017 Category: Endocrinology Source Type: research

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies
The objective of this systematic review and meta-analysis of published observational studies was to investigate mean levels of fetuin-A in T2D patients and the relationship between blood fetuin-A levels and T2D risk.Materials and methodsPubMed, Embase, Google Scholar, Web of Science, and The Cochrane Library were systematically searched for potential relevant studies up to 1 December 2016. Natural logarithm-transformed estimate risks, standard mean differences on the basis of Hedges ’s adjusted g, and 95% confidence intervals (CIs) were calculated for all eligible studies and were combined to measure the pooled data ...
Source: Journal of Endocrinological Investigation - June 22, 2017 Category: Endocrinology Source Type: research

A comparison of clinical efficacy and economic value in Basalin- and Lantus-treated patients with type 2 diabetes using continuous glucose monitoring system
ConclusionGlargine-Basalin is non-inferior in clinical efficacy compared to glargine-Lantus. In view of the large difference in the cost of glargine-Basalin, it would be much more cost-effective for our patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 22, 2017 Category: Endocrinology Source Type: research

San Benedetto teaching two monks
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 21, 2017 Category: Endocrinology Source Type: research

The cell biology of the thyroid-disrupting mechanism of dichlorodiphenyltrichloroethane (DDT)
ConclusionBased on our earlier finding and on the large body of evidence here reviewed, we propose that DDT-induced formation of extracellular vesicles containing the TSH receptor could be directly involved in the development of autoimmune responses against the TSH receptor and that, therefore, their release could lead to the development of the Graves ’ disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 21, 2017 Category: Endocrinology Source Type: research

How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey
ConclusionMedical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 20, 2017 Category: Endocrinology Source Type: research

Teprotumumab: a new avenue for the management of moderate-to-severe and active Graves ’ orbitopathy?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 20, 2017 Category: Endocrinology Source Type: research

Familial hypocalciuric hypercalcemia type 1 due to a novel homozygous mutation of the calcium-sensing receptor gene
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 15, 2017 Category: Endocrinology Source Type: research

Correlation of cardio-metabolic parameters with vitamin D status in healthy premenopausal women
ConclusionsA positive association between vitamin D and HDL cholesterol was found in healthy women without any evidence of metabolic disorders, with a significant inverse correlation between vitamin D and IMT. These results suggest a possible protective role of 25(OH)D in cardiovascular disorders. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 14, 2017 Category: Endocrinology Source Type: research

Methylation markers differentiate thyroid cancer from benign nodules
ConclusionsAberrant gene methylation used in combination panels may be useful clinically in differentiating FTC and PTC from benign nodules. If confirmed in additional studies, these findings could help reduce the over diagnosis of thyroid cancer and surgeries related to over diagnosis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 13, 2017 Category: Endocrinology Source Type: research

Placental and maternal serum activin A in spontaneous and induced labor in late-term pregnancy
ConclusionLate-term pregnancy is characterized by hyperexpression of placental activin A and increased maternal activin A secretion. By combining maternal serum activin A levels with cervical length, a good predictive model for the response to induction of labor was elaborated. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 13, 2017 Category: Endocrinology Source Type: research

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta-analysis
ConclusionThe prevalence of NAFLD is increased in women with PCOS and the presence of NAFLD is associated with high serum androgen levels, in addition to obesity and insulin resistance. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 13, 2017 Category: Endocrinology Source Type: research

The use of nutraceuticals in male sexual and reproductive disturbances: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 6, 2017 Category: Endocrinology Source Type: research

Von Hippel –Lindau disease: a single gene, several hereditary tumors
AbstractThe Von Hippel –Lindau (VHL) disease is an autosomal dominant disorder characterized by the predisposition for multiple tumors caused by germline mutations in the tumor suppressor geneVHL. This disease is associated with a high morbidity and mortality and presents a variable expression, with different phenotypes from family to family, affecting different organs during the lifetime. The main manifestations of VHL are hemangioblastomas of the central nervous system and retina, renal carcinomas and cysts, bilateral pheochromocytomas, cystic and solid tumors of the pancreas, cystadenomas of the epididymis, and en...
Source: Journal of Endocrinological Investigation - June 6, 2017 Category: Endocrinology Source Type: research

Persistence with denosumab therapy in women affected by osteoporosis with fragility fractures: a multicenter observational real practice study in Italy
ConclusionsPersistence to denosumab treatment in our observational real practice study was very high. These results suggest that factors such as frequency of visits, pharmacological schedule, and opportunity to call the doctor might play an important role in the persistence and adherence to treatment to obtain maximum therapeutic effect and avoid further fragility fractures. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 6, 2017 Category: Endocrinology Source Type: research

Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features
AbstractPurposeVitamin D receptor (VDR) and progesterone receptor (PR) expression has been described in papillary thyroid carcinoma (PTC) but data regarding association with tumor histological characteristics and localization of the protein expression are scarce.Materials and methodsFormalin-fixed, paraffin-embedded specimens from 45 patients with PTC (cases) were retrieved and tumor histological data were recorded. We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells an...
Source: Journal of Endocrinological Investigation - June 6, 2017 Category: Endocrinology Source Type: research

The diagnostic value of glycated albumin in gestational diabetes mellitus
AbstractPurposeOur objective was to compare the diagnostic performance of glycated hemoglobin (HbA1c), GA, and fasting plasma glucose (FPG) for the diagnosis of GDM.MethodsWomen at their late second or early third trimesters seen from October 2011 to April 2012 were studied. GDM was diagnosed based on oral glucose tolerance test results, and GA and HbA1c were measured at the same time. Patients were divided into two groups (with and without GDM), and areas under the receiver-operating characteristic curves (AUCs) were calculated to determine the diagnostic value of FPG, GA, and HbA1c.ResultsA total of 698 women were includ...
Source: Journal of Endocrinological Investigation - June 6, 2017 Category: Endocrinology Source Type: research

The relationship between hyperthyrotropinemia and metabolic and cardiovascular risk factors in a large group of overweight and obese children and adolescents
AbstractPurposeMild TSH elevations are frequently observed in obese patients, in the absence of any detectable thyroid disease. Our objective is to evaluate the relationship between the raised TSH levels and the biochemical and clinical consequences of obesity.MethodsThis is a retrospective cross-sectional study of a large population of obese children and adolescents. We evaluated 833 subjects (340 m, 493 f), aged 14.4  ± 2.5 (range 5.2–18.5) years, height SDS 0.27 ± 1.04 (−3.49–4.35), and BMI SDS 2.94 ± 0.59 (1.60–4.68). Body composition, free T4, ...
Source: Journal of Endocrinological Investigation - June 5, 2017 Category: Endocrinology Source Type: research

Can ARFI elastography be used to differentiate parathyroid from thyroid lesions?
AbstractObjectivesTo assess if elasticity score (ES) and shear wave velocity (SWV) measurement obtained using ARFI elastography can differentiate between parathyroid lesions and thyroid nodules.Materials and methodsARFI elastography was performed on patients with primary hyperparathyroidism or solid thyroid nodules who were being considered for surgery using virtual touch quantification and virtual touch imaging (VTI) software. Only patients with surgical histopathology (47 parathyroid lesions, 38 benign thyroid nodules and 55 malignant thyroid nodules) were included for final analysis. SWV and ES of the parathyroid and th...
Source: Journal of Endocrinological Investigation - May 31, 2017 Category: Endocrinology Source Type: research

Anti-thyroglobulin antibodies and risk of finding iodine avid metastases on post-radioactive iodine ablation scan in low-risk thyroid cancer patients
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 31, 2017 Category: Endocrinology Source Type: research

Epstein –Barr virus and thyroid cancer: the controversy remains
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 30, 2017 Category: Endocrinology Source Type: research

Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus
AbstractGestational diabetes mellitus (GDM), defined as any glucose intolerance with the onset or first recognition during pregnancy, is characterized by rising incidence, fostered by the worldwide increase of pathological nutritional status from young age. Clinical research has intended to identify potential risk factors, suggested improvements in screening strategies, and recommended the combination between promotion of an appropriate lifestyle before and during pregnancy and selected therapeutic approaches. Preventing pathological hyperglycemia could have several benefits, ranging from clinical side (reduction in the ri...
Source: Journal of Endocrinological Investigation - May 29, 2017 Category: Endocrinology Source Type: research

Histomorphometric changes following treatment for osteoporosis
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study
AbstractOctreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the fir...
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Determination of spermatic vein reflux after varicocele repair helps to define the efficacy of treatment in improving sperm parameters of subfertile men
AbstractPurpose A continuous spermatic venous reflux (SVR) at colour Doppler ultrasound (CDU) is an evidence for varicocele, a frequent correlate for male subfertility. We explored whether SVR after left varicocele repair is predictive for changes in semen quality in subfertile men.Methods Blood hormones (FSH, LH, and total testosterone) and scrotal CDU were obtained in subfertile patients with left grade II or grade III varicocele on physical evaluation and a poor sperm quality. Semen analysis and CDU were re-evaluated 6  months after a retrograde internal spermatic vein scleroembolisation.ResultsThe retrospectiv...
Source: Journal of Endocrinological Investigation - May 25, 2017 Category: Endocrinology Source Type: research

Levothyroxine monotherapy versus levothyroxine and selenium combination therapy in chronic lymphocytic thyroiditis
This study aimed to assess whether combination of levothyroxine treatment and selenium (Se) supplementation results in improved therapeutic effects in CLT compared with levothyroxine monotherapy.MethodsAn open-label, randomized controlled study was performed in 60 CLT patients assigned to two groups. Levothyroxine group (LT) patients (n = 24) received levothyroxine alone for 3 months; meanwhile, the combination (LTSS) group (n = 36) was administered levothyroxine with selenium yeast capsule. Blood selenium concentrations, anti-thyroid peroxidase (TPO) and anti-thyroglobulin (Tg) antibody levels, an...
Source: Journal of Endocrinological Investigation - May 22, 2017 Category: Endocrinology Source Type: research

Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis
AbstractPurposeOvert hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients.MethodsIn this prospective study we consecutively included all patients ≥60 years admitted by the Internal Medicine Department to the hospital ward (n = 451...
Source: Journal of Endocrinological Investigation - May 22, 2017 Category: Endocrinology Source Type: research

The unresolved riddle of glucocorticoid withdrawal
AbstractGlucocorticoid (GC) therapy is the most common cause of adrenal insufficiency (AI). The real prevalence of AI after GC is unknown but it could involve more than 30% of patients. Some gene variation has been associated with the variability of hypothalamic-pituitary-adrenal (HPA) axis and this issue could contribute to the individual variation of adrenal function after GC treatment. Symptoms and signs of AI are nonspecific and frequently the diagnosis is delayed. Dosage, duration of treatment, administration route and serum cortisol value are not completely useful to predict AI. Clinical estimation of HPA suppression...
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research

Benefits of a regular vs irregular rhythm-based training programme on physical fitness and motor skills in obese girls
ConclusionThese findings demonstrate that physical exercise at various tempos is useful for improving physical fitness, developing MS, and thus probably preventing obesity complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research