The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults
Conclusion The CTLA-4 + 49 A/G polymorphism confers genetic susceptibility to LADA and T1DM, while the CTLA-4 CT60 polymorphism is only associated with T1DM in Chinese population. The CTLA-4 + 49 A/G genotype distribution in LADA is associated with the GADA level. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

Thanks to Reviewers 2014
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

Lipid abnormalities in patients with adrenal incidentalomas: role of subclinical hypercortisolism and impaired glucose metabolism
Abstract Background Subclinical hypercortisolism (SH) has been associated with metabolic complications such as type 2 diabetes mellitus, obesity and dyslipidemia. Scarce data are available regarding the lipid pattern abnormalities in SH, in relation to insulin resistance and impaired glucose metabolism (IGM). We aimed to evaluate the possible influence of SH on lipid pattern in relation to the presence/absence of impaired glucose metabolism. Methods In 338 patients with adrenal incidentaloma, the presence of SH, hypertension, dyslipidemia and IGM was eva...
Source: Journal of Endocrinological Investigation - January 23, 2015 Category: Endocrinology Source Type: research

The association between lipid parameters and obesity in university students
Abstract Background Abdominal obesity is associated with high plasma triglyceride and with low plasma high-density lipoprotein cholesterol levels. Aim and methods Objective of the study was to find an association between plasma lipid and lipoprotein levels and anthropometric parameters in abdominal obesity in Slovakian university students. Lipid profile and anthropometric parameters of obesity were studied in a sample of 419 probands, including 137 men and 282 women. Results Males had higher values of non-high-dens...
Source: Journal of Endocrinological Investigation - January 20, 2015 Category: Endocrinology Source Type: research

Premature ovarian insufficiency: from pathogenesis to clinical management
Abstract Premature ovarian insufficiency (POI) represents a condition characterized by the absence of normal ovarian function due to an incipient (by 3–10 years) ovarian aging. In most of the women affected there are no signs or symptoms that precede the interruption of menstruation and the onset of POI and the majority of women have a normal history of menarche, regular menstrual cycles and normal fertility. The possible genetic role in the development of POI has been largely demonstrated and many genes have been involved; on the other hand, ovary is not protected immunologically and the detection ...
Source: Journal of Endocrinological Investigation - January 18, 2015 Category: Endocrinology Source Type: research

Long-term outcome of Graves’ orbitopathy following high-dose intravenous glucocorticoids and orbital radiotherapy
Conclusions Given the limitations of retrospective investigations, our study confirms that the combination of GC and ORT is effective in GO and shows that females have greater chances to respond to treatment. The notorious tendency of GO to improve spontaneously with time most likely contributes the long-term outcome of the eye syndrome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 18, 2015 Category: Endocrinology Source Type: research

Calcium–phosphate metabolism in patients with multiple sclerosis
Conclusions In RRMS patients, calcium–phosphate metabolism is disturbed which increases during disease progression. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 18, 2015 Category: Endocrinology Source Type: research

Perspectives on osteoporosis therapies
Abstract Osteoporosis is a skeletal disease which predisposes to fragility fractures with high morbidity and economic impact, and, therefore, the goal of any osteoporosis treatment is to reduce the fracture risk. In the various forms of osteoporosis an imbalance between bone resorption and apposition is present, that generally leads to a reduction of bone mineral density and bone quality, and finally to the increased fracture risk. Nowadays, several drugs are available with a demonstrated anti-fracturative effect obtained by inhibiting bone resorption or stimulating bone formation. However, their use is not fr...
Source: Journal of Endocrinological Investigation - January 11, 2015 Category: Endocrinology Source Type: research

MicroRNA deregulation in parathyroid tumours suggests an embryonic signature
In conclusion, miRNAs might provide new diagnostic markers and new therapeutic approaches by developing molecular miRNA-targeted therapies for the cure of parathyroid tumours, whose unique option is surgery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 11, 2015 Category: Endocrinology Source Type: research

Prospectively recorded and MedDRA-coded safety data of intravenous methylprednisolone therapy in Graves’ orbitopathy
Conclusions Prospective and standardized evaluation with MedDRA and the ICH guideline demonstrated the good pharmacological tolerance and low morbidity of this moderate steroid regimen. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 10, 2015 Category: Endocrinology Source Type: research

Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes?
Abstract Purpose To evaluate the Vitamin D status of patients with a single autoimmune disease and of patients with several autoimmune diseases. Methods We enrolled 35 patients with isolated type 1 diabetes mellitus (T1DM), 60 with autoimmune polyendocrine syndromes (APS) including T1DM and 72 control subjects. Among patients with APS, 10 were classified as type 2 (Addison’s disease + T1DM), whereas the other 50 as type 3 (autoimmune thyroid disease + T1DM + other autoimmune diseases). Vitamin D (25-OHD) levels were as...
Source: Journal of Endocrinological Investigation - January 10, 2015 Category: Endocrinology Source Type: research

Clinical risk model assessment for cardiovascular autonomic dysfunction in the general Chinese population
Conclusion CA dysfunction prevalence was high in the general Chinese population, and its prevalence was more frequent in individuals with diabetes, and hypertensive, and metabolic syndrome. Clinical risk models with a high value for predicting CA dysfunction were developed. CA dysfunction has become a major public health problem in China that requires strategies aimed at the prevention and treatment of the disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2015 Category: Endocrinology Source Type: research

Twelve-month treatment with Liraglutide ameliorates Visceral Adiposity Index and common cardiovascular risk factors in type 2 diabetes outpatients
Abstract Aim In addition to the effects on glycemic control and body weight, GLP-1 receptor agonists may favorably affect other major cardiovascular disease (CVD) risk factors, although currently available data are still sparse. In this retrospective study, we evaluated the effects of 12-month treatment with liraglutide on major CVD risk factors in 115 type 2 diabetes outpatients (60 men and 55 women), on stable hypoglycemic, anti-hypertensive and/or lipid-lowering therapy. Methods Clinical and anthropometric data, metabolic and lipid profile, as ...
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Treatment of post-menopausal osteoporosis: beyond bisphosphonates
Abstract Osteoporosis is a highly prevalent condition, characterized by compromised bone strength and fragility fractures and with an important associated socio-economic burden. Bisphosphonates are well established as the first line treatment for osteoporosis. However, while randomized control trials have in general demonstrated reasonable anti-fracture efficacy at the spine, they have shown moderate reduction in fracture incidence for non-vertebral sites. Furthermore, oral bisphosphonates are commonly associated with adverse gastrointestinal effects and both oral and parenteral bisphosphonates have been linked w...
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Importance of specific reference values for evaluation of the deteriorating thyroid function in patients with end-stage renal disease on hemodialysis
Abstract Background/Aim We evaluated the thyroid function in end-stage renal disease (ESRD) on maintenance hemodialysis. Material/Methods Thyroid function and clinical hypothyroid score were evaluated in 145 ESRD patients. Results Comparison of thyroid function between 127 ESRD patients, excluding 18 patients with suppressed or elevated serum TSH level, and age/sex-matched healthy controls (76 in midlife group aged under 65 and 51 in late-life group aged 65 or over) using a multivariate logistic regressi...
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk
Conclusions Blood mercury concentration was independently associated with an increased risk of MetS in men. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Spying on organelle Ca 2+ in living cells: the mitochondrial point of view
Abstract Over the past years, the use of genetically encoded Ca2+ indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca2+ homeostasis in living cells leading to novel insights into functional aspects of Ca2+ signalling. Particularly relevant for a deeper understanding of these key aspects of cell pathophysiology has been the possibility of imaging changes in Ca2+ concentration not only in the cytoplasm, but also inside organelles. In this review, we will provide an overview of the ongoing developments in the use of GECIs, with particular focus on mitoc...
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Effects of vitamin D supplements on bone density
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway
Conclusion GLP-1 receptor agonist increases the expression of CTRP3 mRNA and protein in 3T3-L1 adipocytes via PKA signal pathway. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

Association of height with peripheral arterial disease in type 2 diabetes
Abstract Objective To investigate whether height is associated with peripheral arterial disease (PAD) in patients with type 2 diabetes. Research design and methods This was an observational study performed in 4,528 Chinese patients with type 2 diabetes. Anthropometric measures and the ankle-brachial index (ABI) were performed on each subject. PAD was defined as those patients with a history of revascularization or amputation due to ischemia, or an ABI 
Source: Journal of Endocrinological Investigation - January 1, 2015 Category: Endocrinology Source Type: research

TSHR intronic polymorphisms (rs179247 and rs12885526) and their role in the susceptibility of the Brazilian population to Graves’ disease and Graves’ ophthalmopathy
Conclusion We demonstrate that thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves’ disease and Graves’ ophthalmopathy in the Brazilian population, but do not appear to influence the disease course. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 27, 2014 Category: Endocrinology Source Type: research

Prematurity and low birth weight lead to altered bone geometry, strength, and quality in children
Abstract Purpose Prematurity and low birth weight are associated with a decrease in bone mass. Aim of the study was to investigate bone geometry, strength, and quality in children born at term small for gestational age (term SGA), premature appropriate for gestational age (prem AGA), and premature SGA (prem SGA). Methods 91 patients (46 f, 45 m), mean age 11.28 years, height SDS 0.03 ± 0.21, and BMI SDS −0.31 ± 0.19. 20 were term SGA, 22 prem SGA, and 49 prem AGA. Bone geometry was assessed on the 2n...
Source: Journal of Endocrinological Investigation - December 25, 2014 Category: Endocrinology Source Type: research

Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis
Abstract Background Vitamin D is a multifunctional pro-hormone and has widespread actions in human body. Several studies showed a possible association between vitamin D deficiency and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes, but no definite conclusion was available. Methods A systematic review and meta-analysis was performed to comprehensively assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and DPN in patients with type 2 diabetes. Data from eligible studies were pooled using meta-analysis. ...
Source: Journal of Endocrinological Investigation - December 20, 2014 Category: Endocrinology Source Type: research

The impact of prenatal exposure to a single dose of testosterone on insulin resistance, glucose tolerance and lipid profile of female rat’s offspring in adulthood
Conclusion Our study suggests that metabolic disturbances in PCOS and their severity during adult life probably depend on the particular time and levels of prenatal androgen exposure. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 20, 2014 Category: Endocrinology Source Type: research

Incidental ganglioneuromas: a presentation of 14 surgical cases and literature review
Conclusions Our data widen the knowledge about ganglioneuroma and confirm that the surgical approach has an excellent prognosis with very low incidence of surgery-related complications and recurrences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 13, 2014 Category: Endocrinology Source Type: research

High frequency of splice site mutation in 21-hydroxylase deficiency children
Conclusion The genetic analysis of the splice site mutation c.293-13A>G and c.518T>A variant can be used as good biomarkers for early detection of cases and carriers in 21-OHD CAH Egyptian children, since the methods used have rapid turnaround time. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 13, 2014 Category: Endocrinology Source Type: research

Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways
Conclusions In rodents, reductions in leptin levels that physiologically occur following acute food deprivation or a reduction of the fat mass consequent to prolonged caloric restrictions are associated with a decrease in total locomotor activity and simultaneous increase in food-anticipatory activity, a locomotor behavior which reflects a foraging attitude. These actions can be prevented by leptin administration and are at least partially mediated by the neurons of the melanocortin pathway. In humans, twin studies have attributed to genetic factors approximately 50 % of the variance of physical activity. An...
Source: Journal of Endocrinological Investigation - December 13, 2014 Category: Endocrinology Source Type: research

Prognostic factors for pancreatic neuroendocrine neoplasms (pNET) and the risk of small non-functioning pNET
Conclusions Among NF-pNET, large neoplasms were associated with worse outcomes; however, small NF-pNET do not seem to have an invariable benign behavior. Whether surgery should be avoided in all patients with small NF-pNET is questionable. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2014 Category: Endocrinology Source Type: research

Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?
This study aimed to examine the relationship between Gal-3 and newly diagnosed prediabetes and diabetes. Methods Gal-3 concentrations were measured in 118 participants and 56 age- and sex-matched healthy controls. All subjects underwent a 75-g oral glucose tolerance test and were stratified into normal, prediabetic, and diabetes mellitus subgroups. DM was defined as a plasma glucose level ≥126 mg/dL in the fasting state or ≥200 mg/dL in the second hour after glucose loading. Impaired fasting glucose was defined as an FPG level of 100–125 mg/dL, and impaired...
Source: Journal of Endocrinological Investigation - December 12, 2014 Category: Endocrinology Source Type: research

Characterization of V804M-mutated RET proto-oncogene associated with familial medullary thyroid cancer, report of the largest Turkish family
Conclusions Our study revealed a relatively good prognosis in patients with V804M mutation. Despite the surgery was performed in older age no advance disease was observed. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2014 Category: Endocrinology Source Type: research

Genetic defects of the CYP21A2 gene in girls with premature adrenarche
Conclusions In girls with PA, the frequency of the underlying CYP21A2 genetic defects is similar to that observed in other populations. The carrier status is likely a contributing factor in the genotype–phenotype correlation in NC-CAH. However, polymorphisms and other genes may be implicated in the clinical manifestation of the disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 7, 2014 Category: Endocrinology Source Type: research

Human recombinant follicle stimulating hormone (rFSH) compared to urinary human menopausal gonadotropin (HMG) for ovarian stimulation in assisted reproduction: a literature review and cost evaluation
Conclusions Recombinant follicle-stimulating hormone treatment resulted in a higher oocytes yield per cycle than human menopausal gonadotropin at similar cost per oocyte. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 6, 2014 Category: Endocrinology Source Type: research

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women
Conclusion GDM is not associated with OC, ucOC, OPN, and leptin and does not correlate with insulin resistance. At postpartum, women who develop diabetes have lower osteocalcin concentrations. Leptin correlates with insulin resistance and bone biomarkers in non-diabetic women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 6, 2014 Category: Endocrinology Source Type: research

Complete clinical and biochemical control with cabergoline and octreotide in a patient with ectopic ACTH syndrome before surgery
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 6, 2014 Category: Endocrinology Source Type: research

Cardiovascular risk factors and events in women with androgen excess
Abstract Androgen excess (AE) was approximated to be present in 7 % of the adult population of women. Polycystic ovary syndrome (PCOS) is the most prevalent among them, followed by idiopathic hirsutism (IH), congenital adrenal hyperplasia (CAH), hyperandrogenic insulin-resistant acanthosis nigricans (HAIRAN) syndrome, and androgen-secreting neoplasms (ASNs). Increased cardiovascular risk was implicated in women with AE. Serum testosterone independently increases risk for cardiovascular disease (CVD), and correlates even with indices of subclinical atherosclerosis in various populations of postmenopausal women...
Source: Journal of Endocrinological Investigation - November 28, 2014 Category: Endocrinology Source Type: research

The effect of 17β-estradiol on the expression of dipeptidyl peptidase III and heme oxygenase 1 in liver of CBA/H mice
Conclusions We demonstrate for the first time that E2 influences the protein level of DPP III in vivo, and confirm earlier finding on HO-1 gene upregulation by 17β-estradiol. These results additionally confer new insights into complexity of protective action of E2. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 28, 2014 Category: Endocrinology Source Type: research

The evaluation of Nesfatin-1 levels in patients with OSAS associated with metabolic syndrome
Conclusion Nesfatin-1 which is known to play a role in the pathophysiology of insulin resistance can be a beneficial target in developing new therapeutic targets for treatment of patients with obesity without any toxic effects in the future. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 28, 2014 Category: Endocrinology Source Type: research

Effect of hydrocortisone replacement therapy on body mass index after pituitary surgery
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 28, 2014 Category: Endocrinology Source Type: research

Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose–response randomized trial
Abstract Purpose To determine the dose-dependent effects of testosterone administration on cognition in women with low testosterone levels. Methods 71 hysterectomized women with or without oophorectomy with total testosterone
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

GLP-1: benefits beyond pancreas
Conclusion Finally, the GLP-1 has been demonstrated to have a beneficial effect on both vascular, degenerative diseases of central nervous system and psoriasis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Diagnostic pitfalls in the assessment of congenital hypopituitarism
Conclusions It is important to suspect congenital hypopituitarism in the presence of persistent neonatal hypoglycemia associated with jaundice and of a precocious and severe reduction of the growth velocity in childhood. In all these cases, it is necessary to undertake a hypothalamic–pituitary magnetic resonance imaging scan as soon as possible, and to start appropriate treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

The gonadal function in obese adolescents: review
Abstract This review deals with the relationship between obesity in male adolescents and gonadal function. The article is structured in two main paragraphs; the first one is about population studies that have assessed puberty timing and its mode of onset in relation with body weight to evaluate if and how the latter can influence the gonadal function in this phase of life. These studies analyze issues such as increased BMI and early onset of male puberty, gender differences, secular trend toward early onset of puberty in males, effects of a different body composition on male puberty and consequences of a differen...
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

All roads bring to Rome: a different way for predicting success in the therapy of obesity through psychological features
Conclusions Mean weight loss obtained with lifestyle interventions is confirmed to be rather small and a more accurate selection of patients to be enrolled in lifestyle intervention programs is needed. The present study provides some intriguing information on predictors of weight loss, which could be useful for the identification of patients with a higher chance of succeeding with lifestyle programs for the treatment of obesity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Evolution of benign thyroid nodules under levothyroxine non-suppressive therapy
Abstract Background Non-suppressive or partially suppressive L-T4 treatment demonstrated to be effective in reducing the volume of the nodules. However, studies with long follow-up are lacking and significant controversy exists regarding the efficacy of non-suppressive L-T4 treatment in benign nodular goiter. Aim The goal of this study was to determine the evolution of thyroid nodules in subjects treated with a non-suppressive levothyroxine (L-T4) dose, compared to untreated subjects. Design and patients ...
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Thymic hyperplasia in patients with Graves’ disease
Conclusion We support the hypothesis that two different pathogenic mechanisms might be responsible for thymus enlargement: thymic cortical tissue expansion seems to be due to a hyperthyroid state, while lymphoid hyperplasia appears to correlate with immune abnormalities underlying GD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Factors related to mortality in patients with papillary and follicular thyroid cancer in long-term follow-up
Abstract Purpose Differentiated thyroid cancer (DTC) includes papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC). They have different biological behavior but are frequently analyzed together in studies. We aimed to identify factors associated with mortality in those two different cancer subtypes. Methods Case series study, with clinical–pathological analysis of the characteristics of 424 patients with PTC and 89 patients with FTC, correlating them to survival rates in a single institution. Res...
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Comparative effects of metformin and pioglitazone on YKL-40 in type 2 diabetes: a randomized clinical trial
Conclusions Metformin is more effective in reduction of YKL-40 concentration in short term and the effect seems to be independent of degree of glycemic control, or hsCRP reduction. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2014 Category: Endocrinology Source Type: research

Role of genetic and non-genetic factors in the etiology of Graves’ disease
Abstract In spite of the advancements in understanding the pathogenic mechanisms of Graves’ disease (GD), its ultimate cause remains elusive. The majority of investigators agree that GD is likely a multifactorial disease, due to a complex interplay of genetic and non-genetic factors that lead to the loss of immune tolerance to thyroid antigens and to the initiation of a sustained autoimmune reaction. Twin and family studies support a role of genetic factors, among which the HLA complex, CD40, CTLA-4, PTPN22, FCRL3, thyroglobulin, and the TSH receptor may be involved. Among non-genetic factors, iodine, infect...
Source: Journal of Endocrinological Investigation - November 25, 2014 Category: Endocrinology Source Type: research

Retrospective comparison of cabergoline and bromocriptine effects in hyperprolactinemia: a single center experience
Abstract Introduction Patients with hyperprolactinemia who require medical therapy are typically treated with dopamine agonists (DAs). In most cases, DAs normalize prolactin levels, control symptoms, and substantially decrease tumor size. Here, we aimed to compare the efficacy of cabergoline (CAB) and bromocriptine (BRC) in patients with hyperprolactinemia at a single center. Methods Retrospective analysis of the clinical records of 498 patients with hyperprolactinemia [mean age 33.3 ± 10.8 years (range 16–66), 450 women, and ...
Source: Journal of Endocrinological Investigation - November 25, 2014 Category: Endocrinology Source Type: research

Gastrointestinal and renal side effects of bisphosphonates: differentiating between no proof of difference and proof of no difference
Conclusion Our study provided quantitative information to determine to what extent bisphosphonates can be considered equivalent in terms of gastrointestinal and renal side effects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 21, 2014 Category: Endocrinology Source Type: research