The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy
Abstract Background The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population. Method We conducted a large-scale, population-based study to analyze the association and interaction of the two factors for CAN in a sample of 2092 Chinese people. Univariate and multiple linear regression (MLR) analysis were employed to detect these relationships. Interaction o...
Source: Journal of Endocrinological Investigation - April 23, 2015 Category: Endocrinology Source Type: research

Papillary thyroid carcinoma and multiple endocrine neoplasia type 2
Conclusions Few data are available about PTC in MEN 2, and without C-cell pathology is even less common. More studies are needed to correlate genetics and histology, and even for assessing PTC as only manifestation of MEN 2. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 23, 2015 Category: Endocrinology Source Type: research

Serum prolidase levels in Graves’ disease without ophthalmopathy and its association with oxidative status
Abstract Objective The aim of this study was to evaluate serum prolidase levels and its association with oxidative stress in autoimmune thyroid disease (AITD). Materials and methods 25 with Hashimoto thyroiditis (HT) and 25 patients Graves’ disease (GD), and 27 healthy controls were enrolled in the study. The patients with signs of Graves’ ophthalmopathy were excluded from the study. Serum samples were obtained in euthyroid period at the third month of treatment. Serum prolidase, total antioxidant status (TAS), total oxidative stress (TOS), a...
Source: Journal of Endocrinological Investigation - April 22, 2015 Category: Endocrinology Source Type: research

SIAMS survey on sexological screening during the assisted reproductive technologies in Italy
Conclusions To conclude, we noticed a major focus on male sexuality and the eventual treatment or evaluation of sexual dysfunction compared to female sexuality. This aspect highlights an important issue for clinical practice to strongly consider and eventually reinforce. In this regard, improvement of the assessment and treatment of possible female sexual problems in reproductive medicine seems necessary. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2015 Category: Endocrinology Source Type: research

A randomized-controlled, double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes
Abstract Purpose To analyze the impact of selenium supplementation on serum antiTPO levels and thyroid echogenicity in patients with CAT, evaluating the response in subgroups with different GPx1 genotypes. Methods CAT patients (n = 55) with positive antiTPO were randomized to selenomethionine (SeMet) 200 μg daily (n = 28) or placebo (n = 27) for 3 months. Assessments included GPx1 genotyping at baseline and serum levels of plasma selenium, erythrocyte GPx1 activity, antiTPO and thyroid echogenicity at baseline, ...
Source: Journal of Endocrinological Investigation - April 17, 2015 Category: Endocrinology Source Type: research

Bone health in type 1 diabetes: focus on evaluation and treatment in clinical practice
Conclusion There is no consensus about the treatment of diabetic bone disorder. However, the improvement of glycemic control has been suggested to have a beneficial effect on bone in T1D. Recently, several experiments showed promising results on using anabolic pharmacological agents in diabetic rodents with bone disorder. Therefore, randomized clinical trials are needed to test the possible use of the bone anabolic therapies in humans with T1D. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 12, 2015 Category: Endocrinology Source Type: research

Ischemia-modified albumin levels in overt and subclinical hypothyroidism
Abstract Background Free radical-mediated oxidative stress (OS) has been implicated in the pathogenesis of thyroid disorders. The ischemia-modified albumin (IMA) has been proposed as a marker of protein oxidative damage, which has been found to reflect hypoxic stress. Aim Our aim was to evaluate IMA, malondialdehyde (MDA), and reduced glutathione (GSH) levels in patients with overt hypothyroidism (OHT) and subclinical hypothyroidism (SHT) in comparison to euthyroid controls. Subjects and methods Albumin, IMA, IMA/a...
Source: Journal of Endocrinological Investigation - April 11, 2015 Category: Endocrinology Source Type: research

The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus
Conclusions In conclusion, increased endothelin levels in the lung associated with diabetes may be one cause of endothelial dysfunction, cytokine increase, and oxidant/antioxidant imbalance in the pathogenesis of complications that may develop during diabetes. With its multiple effects, bosentan therapy may be an effective option against complications that may develop in association with diabetes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2015 Category: Endocrinology Source Type: research

Female infertility: do we forget the thyroid?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2015 Category: Endocrinology Source Type: research

Psychosine inhibits osteoclastogenesis and bone resorption via G protein-coupled receptor 65
Conclusion Psychosine inhibits osteoclastogenesis by increasing intracellular cAMP levels via GPR65. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2015 Category: Endocrinology Source Type: research

Does segmental body composition differ in women with Prader–Willi syndrome compared to women with essential obesity?
Conclusion Trunk fat is lower in obese women with PWS than in those with essential obesity. Surrogate markers of CMD are, however, mostly similar in the two groups. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 4, 2015 Category: Endocrinology Source Type: research

Pregnancy outcome in women treated with methimazole or propylthiouracil during pregnancy
Conclusions While a clear demonstration of a teratogenic effect of MMI is currently lacking, it seems reasonable to follow the current guidelines and advice for PTU treatment in hyperthyroid women during the first trimester of pregnancy. Further, large and prospective worldwide studies will be needed to fully clarify the issue of ATD safety during pregnancy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 4, 2015 Category: Endocrinology Source Type: research

How to manage the reproductive issues of PCOS: a 2015 integrated endocrinological and gynecological consensus statement of the Italian Society of Endocrinology
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 3, 2015 Category: Endocrinology Source Type: research

Knowledge, attitudes and behaviors of physicians towards thyroid disorders and iodine requirements in pregnancy
Abstract Purpose Thyroid disorders including iodine deficiency during pregnancy are important health problems worldwide. However, considering real life, assessment of knowledge, attitudes, and practice of physicians is lacking. We aim to evaluate knowledge, attitudes and behaviors of physicians towards thyroid disorders and requirements of iodine during pregnancy on a nationwide basis. Methods Clinicians from different medical disciplines most likely to encounter pregnant women in daily practice (i.e., obstetricians, endocrinologists, and family physicia...
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

Analysis of renal functions and proteinuria in young obese adults
Conclusion Obesity can pose an independent risk factor for proteinuria in young adults. Hypertension, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with obesity. eGFR decreased with a higher number of risk factors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

Evaluation of function and structure of arterial wall in girls and young women with Turner syndrome
Abstract Purpose Patients with Turner syndrome (TS) are frequently affected by congenital as well as acquired cardiovascular diseases. The aim of the study was to evaluate the blood pressure, the endothelial function (FMD) and the intima media thickness (IMT) at the level of the common carotid arteries in a group of girls and young women with TS in comparison to healthy controls. Methods We evaluated 40 unselected TS patients, with a mean age of 18.6 ± 0.9 years and 103 age matched healthy subjects. Main outcome measures: blood pres...
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche
Abstract Aim We aimed to investigate serum nesfatin-1 level in girls with premature thelarche (PT) and its relationship with anthropometric parameters and leptin, which are involved in the initiation of pubertal process. Subjects-methods Non-obese girls who presented with the complaint of early (2–8 years) and isolated breast development were included in the study. The control group consisted of age-matched healthy prepubertal girls. Auxological measurements were performed in all subjects. Gonadotropin-releasing hormone (GnRH) stimulation test...
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

Methodological limitations of an etiological framing of Ariarathes’ goitre: response to Tekiner et al.
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

Man with enormous trilobar goiter
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2015 Category: Endocrinology Source Type: research

The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto’s thyroiditis
Conclusions The results of our study support the association between benign breast diseases and thyroid diseases. An important implication of this finding may be demonstration of the necessity of scanning for potential breast pathology in women with nodular or autoimmune thyroid disease in clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 1, 2015 Category: Endocrinology Source Type: research

The effect of maternal hypothyroidism on cardiac function and tolerance to ischemia–reperfusion injury in offspring male and female rats
Abstract Purpose Accumulating evidence indicates that intrauterine evolution disturbance can contribute to myocardial ischemia reperfusion (IR) injury; in addition, thyroid hormones (THs) have a crucial role in the development of different systems during fetal life. The aim of this study was to determine the effect of TH deficiency during fetal life on tolerance of isolated heart to ischemia during adulthood in both genders. Methods Hypothyroidism was induced in pregnant Wistar rats by administrating 0.025 % 6-propyl-2-thiouracil in drinking water t...
Source: Journal of Endocrinological Investigation - March 31, 2015 Category: Endocrinology Source Type: research

Italian Society of Endocrinology Consensus Statement: definition, evaluation and management of patients with mild primary hyperparathyroidism
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 28, 2015 Category: Endocrinology Source Type: research

Cost-effectiveness analysis of two therapeutic schemes in the treatment of acromegaly: a retrospective study of 168 cases
Conclusions In acromegalic patients with macroadenoma, the cost-effectiveness analysis revealed more satisfactory outcomes in preoperative therapy, compared with primary surgery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 18, 2015 Category: Endocrinology Source Type: research

5α-Reductase inhibitors increase acute coronary syndrome risk in patients with benign prostate hyperplasia
Conclusion This population-based nested case–control study suggests that 5ARI use may increase ACS risk among patients with BPH when patients were exposed to both finasteride and dutasteride. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 17, 2015 Category: Endocrinology Source Type: research

Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas
Abstract Background Diabetes mellitus is globally the major cause for metabolic syndrome in STZ-induced diabetic rats, leading to mortality. Treatment of diabetes by oral hypoglycemic agents causes adverse side effects and thus treatment with natural herbal drugs like swertiamarin is promising. Swertiamarin, an active compound isolated from Enicostemma littorale possesses antidiabetic activity and enhances β cell regeneration which causes reversal of diabetes. Objectives The present study aims at the following: (1) to evaluate antidiabetic, anti-hyp...
Source: Journal of Endocrinological Investigation - March 14, 2015 Category: Endocrinology Source Type: research

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk
Abstract Purpose We carried out a case–control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). Methods We evaluated 125 TC patients and 103 controls. Seminal fluid examination and organochlorine analysis were performed in all subjects. Cases and controls were also interviewed using a structured questionnaire to collect demographic information, residence, andrological medical history and dietary information. Results ...
Source: Journal of Endocrinological Investigation - March 14, 2015 Category: Endocrinology Source Type: research

Myocardial fat as a part of cardiac visceral adipose tissue: physiological and pathophysiological view
Abstract Thoracic fat includes extra-pericardial (outside the visceral pericardium) and intra-pericardial (inside the visceral pericardium) adipose tissue. It is called ectopic adipose tissue although it is a normal anatomical structure. Intra-pericardial adipose tissue, which is predominantly composed of epicardial and pericoronary adipose tissue, has a significant role in cardiovascular system function. It provides metabolic-mechanical support to the heart and blood vessels in physiological conditions, while it represents metabolic-cardiovascular risk in case of qualitative and quantitative structural changes in...
Source: Journal of Endocrinological Investigation - March 14, 2015 Category: Endocrinology Source Type: research

Women self-perception of excess hair growth, as a predictor of clinical hirsutism: a population-based study
Conclusions Patient’s self-identification of excess terminal hair based on the chin area has great sensitivity and reliability in predicting the clinical hirsutism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Embolization of left spermatic vein in non-obstructive azoospermic men with varicocele: role of FSH to predict the appearance of ejaculated spermatozoa after treatment
Abstract Purpose Varicocele repair in non-obstructive azoospermia (NOA) was occasionally associated to ejaculated spermatozoa independently from clinical and laboratory measures. We performed a prospective study in infertile men affected by NOA and left side varicocele to find whether or not the appearance of ejaculated spermatozoa after varicocele repair is predicted by baseline measures. Methods Patients with NOA and grade II, or grade III left side varicocele were submitted to hormone analysis and to scrotal color Doppler ultrasound (CDU). Azoospermia...
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Mechanistic approach to the pathophysiology of target organ damage in hypertension from studies in a human model with characteristics opposite to hypertension: Bartter’s and Gitelman’s syndromes
Conclusions The information obtained from these studies can clarify, confirm or be used to extend the biochemical mechanisms responsible for the pathophysiology of hypertension and its long-term complications and could offer further chances to identify additional potential significant targets of therapy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Reference ranges for an automated chemiluminescent assay for serum insulin-like growth factor I (IGF-I) in a large population of healthy adults from Buenos Aires
In conclusion, this study provides age- and gender-adjusted normal reference ranges for IGF-I levels obtained with an automated immunometric chemiluminescent assay Immulite 2000 in healthy adult subjects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome
Conclusions Data from this and animal studies suggest a possible relationship between androgens and ZP4 expression. ZP4 expression is highest among patients with PCOS and a regular cycle, and this is a consequence of the presence of mature follicles in this group. In some patients with PCOS and infertility, ZP4 mutation can be found. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Detection of global hypermethylation in well-differentiated thyroid neoplasms by immunohistochemical (5-methylcytidine) analysis
Abstract Purpose While global hypomethylation of DNA has been found in several malignancies, studies on thyroid tumours have shown controversial results using different techniques. To help resolve this issue, we assessed methylation status using two different techniques in papillary thyroid carcinomas (PTC) and follicular adenomas (FA) and carcinomas (FTC), comparing adjacent non-neoplastic thyroid tissue. Methods A series of 15 FA, 18 FTC and 17 PTC were assessed by: (1) measurement of methylation levels of long interspersed nuclear elements (LINE-1) us...
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism
The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25–25 µg/day) on left ventricular diastolic function in patients with SH. Materials and methods 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT. Results At baseline, patients with SH showed significantly lower E (0.79 ± 0.22 vs...
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Total thyroid ablation in Graves’ orbitopathy
Abstract Graves’ orbitopathy (GO) is an autoimmune condition almost always associated with autoimmune thyroid disease, especially Graves’ disease (GD). According to the most widely accepted model, the autoantigens responsible for GO would include molecules expressed by thyroid epithelial cells that are present also in orbital tissues. The high likelihood that the etiologies of GO and of the underlying autoimmune thyroid diseases are somehow linked is confirmed by the very close relationship between GO, the onset and the course of Graves’ diseases, the size of the thyroid gland, and most important...
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Serum 25-hydroxyvitamin D predict prognosis in radioiodine therapy of Graves’ disease
Abstract Purpose To investigate serum 25-hydroxyvitamin D 25(OH)D status and assess the predictability of outcome in patients with Graves’ disease (GD) who received a patient-specific calculated dose of radioiodine therapy (RIT). Methods 128 patients with GD who received RIT from July 2010 to September 2010 were included. Pre-therapy serum levels of 25(OH)D, calcium, phosphorus, parathyroid hormone, free triiodothyronine, free thyroxine, thyroid stimulating hormone and creatinine were measured. 60 age- and BMI-matched healthy subjects were chosen a...
Source: Journal of Endocrinological Investigation - March 4, 2015 Category: Endocrinology Source Type: research

Thyroid-stimulating immunoglobulins indicate the onset of dysthyroid optic neuropathy
Abstract Purpose Recognition of dysthyroid optic neuropathy (DON) requires sensitive diagnostic tools. Clinical assessment may fail to reliably evaluate the acuteness of DON especially if signs for inflammation are missing. Aim of this cross-sectional study was to assess the relationship between thyroid-stimulating immunoglobulins (TSI) and onset of DON. Methods At a multidisciplinary orbital center, serum TSI levels were measured in 180 consecutive patients with thyroid eye disease (TED) and 302 healthy controls with a FDA-cleared cell-based bioassay us...
Source: Journal of Endocrinological Investigation - March 4, 2015 Category: Endocrinology Source Type: research

12 cases of primary thyroid lymphoma in China
Conclusion We analyzed clinical, sonographic and histological features of twelve cases of malignant lymphoma arising in the thyroid gland and proposed a systematic strategy for prompt and accurate diagnosis of PTL. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 4, 2015 Category: Endocrinology Source Type: research

Hypoglycemia affects the changes in endothelial progenitor cell levels during insulin therapy in type 2 diabetic patients
Conclusions In naïve T2D patients initiating basal insulin, hypoglycemia prevents the increase in vasculoprotective PCs. Clinically, these data strengthen the importance of avoiding hypoglycemia to improve cardiovascular outcomes during the treatment of T2D. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy
Conclusion Although there was a tendency for patients with isolated lipoatrophy and isolated fat accumulation to present higher IL-6 levels, these differences were not statistically significant. No differences were found relating IL-4 levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients
Conclusions We found that the combination of statin and metformin has no advantage in PCOS management. In fact, the increase of LDL, total cholesterol and FBS within the intervention group warrants reassessment of current regimens to avoid any patient harm. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Surgical menopause versus natural menopause and cardio-metabolic disturbances: A 12-year population-based cohort study
Conclusions Metabolic disturbances after menopause are highly influenced by type of menopause and are more prevalent in those undergoing surgical menopause. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Relationships between thyroid function and autoimmunity with metabolic derangement at the onset of type 1 diabetes: a cross-sectional and longitudinal study
Abstract Background Type 1 diabetes (T1DM) is an autoimmune disease often associated with thyroid abnormalities. Purpose We investigated the correlation between thyroid function and metabolic derangement at onset and the influence of autoimmunity on thyroid function at onset and subsequently. Methods We evaluated 152 patients diagnosed with T1DM between 2000 and 2012 at onset and during a mean follow-up of 5.45 ± 2.8 years. Thyroid function at onset was correlated with metabolic derangement (d...
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Effects of treatment modalities for Graves’ hyperthyroidism on Graves’ orbitopathy: a 2015 Italian Society of Endocrinology Consensus Statement
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

The problem of unrecognized acromegaly: surgeries patients undergo prior to diagnosis of acromegaly
This study included 313 participants, of whom 181 were women. The mean age was 48.8 ± 12.0 years. Patients most frequently presented with acral growth of hands and feet (32.6 %) and headache (26.2 %). Internists were the medical specialists who were most frequently first consulted (29.4 %) then neurosurgeons (11.8 %). Acromegaly was generally diagnosed by endocrinologists (55 %), followed by neurosurgeons (23 %). The median elapsed period prior to diagnosis was 24 months, interquartile range 6.0–48.0 months. Some 45.7 % had undergone surgery; 35.2&nbs...
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Neonatal hyperthyroidism on rat heart: interrelation with nitric oxide and sex
Conclusions The results of this study demonstrating clinically relevant sex-related differences in the pathophysiology of the hyperthyroid heart have raised new questions regarding the mechanisms responsible for the observed differences. This study suggests that sex-related intrinsic factors such as nitric oxide may modulate the response to hyperthyroidism that leads to cardiovascular dysfunction. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 21, 2015 Category: Endocrinology Source Type: research

Aortic stiffness and left ventricular function in patients with differentiated thyroid cancer
Abstract Objective The aim of this study was to investigate aortic stiffness and left ventricular (LV) systolic and diastolic function in patients with differentiated thyroid cancer (DTC) on thyroxine (L-T4) therapy and after L-T4 withdrawal to assess the cardiovascular impact of long-term subclinical hyperthyroidism and short-term overt hypothyroidism. Methods Twenty-four patients who had had total thyroidectomy and radioiodine ablation for differentiated thyroid cancer were studied on two occasions: on TSH suppressive L-T4 therapy (sTSH 0.24&nbs...
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes
This study aimed at assessing the effects of chamomile tea consumption on glycemic control and serum lipid profile in patients with type 2 diabetes mellitus (T2DM). Methods This single-blind randomized controlled clinical trial was conducted on 64 individuals with T2DM (males and females) aged between 30 and 60 years. The intervention group (n = 32) consumed chamomile tea (3 g/150 mL hot water) three times per day immediately after meals for 8 weeks. The control group (n = 32) followed a water regimen for the same intervention period. Fasti...
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults
Conclusion The CTLA-4 + 49 A/G polymorphism confers genetic susceptibility to LADA and T1DM, while the CTLA-4 CT60 polymorphism is only associated with T1DM in Chinese population. The CTLA-4 + 49 A/G genotype distribution in LADA is associated with the GADA level. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

Thanks to Reviewers 2014
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research