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IgG4 serum levels in Graves ’ orbitopathy
ConclusionsOur results suggest that, within GD, there is no relationship between serum IgG4 and GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 21, 2023 Category: Endocrinology Source Type: research

Comparison of SGLT2 inhibitors vs. DPP4 inhibitors for patients with metabolic dysfunction associated fatty liver disease and diabetes mellitus
ConclusionsOur analysis using large-scale real-world data demonstrated the potential advantage of SGLT2 inhibitors over DPP4 inhibitors in patients with MAFLD and DM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2023 Category: Endocrinology Source Type: research

MKRN3 circulating levels in girls with central precocious puberty caused by MKRN3 gene mutations
ConclusionsMKRN3 defect in patients with CPP cannot be predicted by MKRN3 circulating levels, although those patients presented lower protein levels than iCPP. Due to the great inter-individual variability of the assay and the lack of reference values, no precise cut-off can be identified to suspect MKRN3 defect. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2023 Category: Endocrinology Source Type: research

Acromegaly presented with acne vulgaris: a retrospective study with 123 cases
ConclusionsOur findings provide preliminary evidence of the high prevalence of adult acne in acromegaly patients, and a high rate of late-onset acne as well. Traditional anti-acne treatments are less effective. Acne could be considerably relieved by treating acromegaly. Acne remission positively correlated with IGF-1 decline as well, which revealed the correlation between acne and IGF-1. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2023 Category: Endocrinology Source Type: research

Does vitamin D deficiency affect functional outcomes in hip fracture patients? A meta-analysis of cohort studies
ConclusionsDespite the limitations of this study, such as small sample size, heterogeneous outcome assessments, and variable vitamin D measurement techniques, the results demonstrated that screening for vitamin D status and optimizing levels through supplementation could facilitate rehabilitation, promote lifestyle changes, aid in the recovery of independence, and help reduce long-term burdens. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2023 Category: Endocrinology Source Type: research

Correlation study between bone metabolic markers, bone mineral density, and sarcopenia
ConclusionIncreased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 14, 2023 Category: Endocrinology Source Type: research

Establishment of gestational diabetes risk prediction model and clinical verification
ConclusionAge, pre-pregnancy BMI, HbA1C in early pregnancy, blood UA, TG, and HDL-C are independent risk factors for GDM. The risk prediction model established by combining age, pre-pregnancy BMI, and laboratory indicators in the first trimester can provide a theoretical basis for early screening, monitoring, and intervention of GDM high-risk pregnant women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2023 Category: Endocrinology Source Type: research

Role of genetic investigation in the diagnosis of short stature in a cohort of Italian children
ConclusionGenetic analysis is a useful tool in the diagnostic workup of patients with SS, in adapting management and treatment, and in identifying syndromes with mild atypical clinical features. The role of VUS should not be underestimated, particularly when multiple VUS with possible mutual worsening effects are present in the same child. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2023 Category: Endocrinology Source Type: research