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Successful localisation of recurrent thyroid cancer using preoperative patent blue dye injection
ConclusionsA preoperative US-guided injection of PB is a safe, readily available and highly effective technique for localising recurrent tumours, even in small lesions within scarred reoperative neck surgeries. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2024 Category: Endocrinology Source Type: research

The impact of telehealth education on self-management in patients with coexisting type 2 diabetes mellitus and hypertension: a 26-week randomized controlled trial
ConclusionOur findings confirmed that telehealth education effectively enhanced the self-management capabilities of patients with coexisting type 2 diabetes and hypertension, leading to better glycolipid and blood pressure control. The use of telehealth education may potentially improve the interaction between medical staff and patients in the management of chronic diseases. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2024 Category: Endocrinology Source Type: research

Postmenopausal onset of androgen excess: a diagnostic and therapeutic algorithm based on extensive clinical experience
ConclusionsClinical or biochemical features of an aggressive androgen-secreting tumor should lead to urgently obtaining a targeted imaging. At first, an abdominal-pelvic CT scan represents the best choice to perceive adrenal malignancy, and may identify aggressive ovarian tumors. When warning signs are lacking, a calm and orderly work-up allows properly addressing the diagnostic challenge of postmenopausal hyperandrogenism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 13, 2024 Category: Endocrinology Source Type: research

The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging
ConclusionIn summary our studies describe the central effects of LEAP-2 within distinct experimental contexts, and contribute to the comprehension of LEAP-2's role in energy metabolism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 9, 2024 Category: Endocrinology Source Type: research

When to suspect infantile hypercalcemia-1?
ConclusionPatients with serum calcium levels higher than 9.6 mg/dL and a PTH index lower than 0.315 are likely to be affected by HCINF1. Their diagnosis may be confirmed using MS and genetic analysis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 8, 2024 Category: Endocrinology Source Type: research

Role of IL33 in chronic inflammation and microvascular damage as a reflection of organ damage on a cohort of patients with acromegaly
ConclusionSerum IL33 is higher in AP compared to HC; conversely a reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction, strictly dependent on acromegaly and are not influenced by the choice of treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 8, 2024 Category: Endocrinology Source Type: research

Glucocorticoid-induced adrenal insufficiency after therapy with intravenous methylprednisolone in patients with moderate-to-severe and active Graves ’ orbitopathy: assessment with a low-dose corticotropin test
ConclusionFor the first time, our research shows that administering IVMP in 12 weekly pulses can result in GC-induced AI. We suggest that patients should undergo careful evaluation for GC-induced AI, including LDT, after therapy with IVMP according to EUGOGO guidelines. Screening for altered adrenal reserve could prevent life-threatening complications, particularly during acute stress situations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 4, 2024 Category: Endocrinology Source Type: research

Different tumor growth pattern of clinically nonfunctioning pituitary neuroendocrine tumor according to sex and age: a longitudinal study
ConclusionsAmong patients with CNF-PitNET, tumor growth was slower in women aged ≤ 50 years than in men and women aged > 50. These findings may guide the customization of surveillance strategies for CNF-PitNETs according to sex and age. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 4, 2024 Category: Endocrinology Source Type: research

Endocrine manifestations in adults with 22q11.2 deletion syndrome: a retrospective single-center cohort study
ConclusionHypoparathyroidism, hypothyroidism, and obesity are common endocrine manifestations in patients with 22q11DS but are probably underdiagnosed and undertreated, indicating the need for multidisciplinary follow-up including an endocrinologist. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 3, 2024 Category: Endocrinology Source Type: research

Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing ’s syndrome: a propensity score-matched study
ConclusionsPatients with CS have higher EAT volume and coronary plaque burden but less inflammation as detected by EAT density and FAI. The EAT density is associated with EAT volume but not CS itself. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 2, 2024 Category: Endocrinology Source Type: research