Adherence in children with growth hormone deficiency treated with r-hGH and the easypod ™ device
Conclusions The injection-recording system and other characteristics of easypod ™ could enhance the ability of physicians to monitor adherence to r-hGH treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 12, 2016 Category: Endocrinology Source Type: research

Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device
Conclusions The injection-recording system and other characteristics of easypod™ could enhance the ability of physicians to monitor adherence to r-hGH treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 12, 2016 Category: Endocrinology Source Type: research

Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial
The objective of this randomized, controlled, double-blind study was to assess the effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome. Methods Eighty subjects were randomized to receive 50,000 IU vitamin D or matching placebo weekly for 16 weeks. Fasting blood sugar, homeostasis model assessment of insulin resistance, insulin sensitivity (Quicki), serum lipid profiles (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride (TG) and total cholesterol), anthropometric factors and b...
Source: Journal of Endocrinological Investigation - July 11, 2016 Category: Endocrinology Source Type: research

Insulin, insulin receptors, and cancer
Abstract Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms and also hybrid receptors resulting from the IR hemireceptor combination with a hemireceptor of the cognate IGF-1 receptor. These different receptors may bind insulin and its analogs with different affinity and produce different biologic effects. Since many ...
Source: Journal of Endocrinological Investigation - July 1, 2016 Category: Endocrinology Source Type: research

Negative correlation between tumour size and cortisol/ACTH ratios in patients with Cushing’s disease harbouring microadenomas or macroadenomas
Conclusions Despite exhibiting higher plasma ACTH levels, CD patients with MAC presented lower cortisol/ACTH ratios than did patients with MIC, with a negative correlation between tumour size and cortisol/ACTH ratios. The overall postsurgical remission and recurrence rates were similar between MIC and MAC patients, with those with larger and/or invasive tumours showing a lower remission rate. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 30, 2016 Category: Endocrinology Source Type: research

Reappraisal of the indication for radioiodine thyroid ablation in differentiated thyroid cancer patients
Abstract Radioactive iodine therapy is administered to patients with differentiated thyroid cancer (DTC) for eradication of thyroid remnant after total thyroidectomy or, in patients with metastatic disease, for curative or palliative treatment. In past years, thyroid remnant ablation was indicated in almost every patient with a diagnosis of DTC. Nowadays, careful revision of patients’ outcome has introduced the concept of risk-based selection of patients candidate to thyroid remnant ablation. The present review aims to underline the indications for thyroid remnant ablation and to address methodologies to...
Source: Journal of Endocrinological Investigation - June 27, 2016 Category: Endocrinology Source Type: research

Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes
Abstract The morbidity and mortality of diabetes mellitus are mostly attributed to cardiovascular complications. Despite tremendous advancement in glycemic control, anti-diabetic medications have failed to revert vascular impairment once triggered by the metabolic disorder. The angiogenic growth factors, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), are crucial regulators of vessel formation and maintenance starting with embryonic development and continuing through life. In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is to drive vascu...
Source: Journal of Endocrinological Investigation - June 25, 2016 Category: Endocrinology Source Type: research

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin
Conclusions Daily consumption of polyphenol-rich EVOO might improve metabolic control and circulating inflammatory adipokines profile in overweight T2D patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 25, 2016 Category: Endocrinology Source Type: research

Erratum to: Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 24, 2016 Category: Endocrinology Source Type: research

Management of hyperthyroidism due to Graves’ disease: frequently asked questions and answers (if any)
Abstract Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas. Although progress has been made in our understanding of the pathogenesis of the disease, no treatment targeting pathogenic mechanisms of the disease is presently available. Therapies for Graves’ hyperthyroidism are largely imperfect because they are bound to either a high rate of relapsing hyperthyroidism (antithyroid drugs) or lifelong hypothyroidism (radioiodine treatment or thyroidectomy). Aim of the present article is to offer a practical guidance to the reader by providing evidence-based answers to fr...
Source: Journal of Endocrinological Investigation - June 18, 2016 Category: Endocrinology Source Type: research

The anti-estrogenic activity of indole-3-carbinol in neonatal rat osteoblasts is associated with the estrogen receptor antagonist 2-hydroxyestradiol
Conclusions This study is the first to show that a bioactive compound derived from cruciferous vegetables, I3C, abolishes the E2-mediated stimulation of cell activities including, proliferation and differentiation, in rat osteoblasts and increases the 2-hydroxylation of E1, resulting in the formation of inactive and anti-estrogenic metabolites. These results suggest that in neonatal rat osteoblasts, the anti-estrogenic effect of I3C is mediated by 2-OHE2 through ER-α. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 16, 2016 Category: Endocrinology Source Type: research

Influence of early-life and parental factors on childhood overweight and obesity
Abstract Purpose We recently reported that a high BMI and high waist circumference prevalence is present in Sicilian children and that the male gender is associated with a significant risk of obesity. Early-life and parent-related risk factors were investigated 1521 Sicilian children (752 females and 769 males, aged 9.0–14.0 years) to identify biological and environmental factors that can contribute to obesity onset. Methods Anthropometric measurements of children, their urban vs rural area provenience, birth weight and neonatal feedin...
Source: Journal of Endocrinological Investigation - June 16, 2016 Category: Endocrinology Source Type: research

Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture
Abstract Background The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children. Materials and methods This cross-sectional study was conducted in 1022 Saudi children without fracture history [476 boys (age 14.56 ± 1.81, BMI 22.38 ± 5.81) and 546 girls (age 13.57 ± 1.67, BMI 22.24 ± 4.94)] and 234 Saudi children with a history of fracture [...
Source: Journal of Endocrinological Investigation - June 16, 2016 Category: Endocrinology Source Type: research

Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome
Conclusion Matsuda’s ISIs derived from OGTT and MMT can be used instead of each other, and interestingly, we found a decrease in TOS levels after OGTT in patients with PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 14, 2016 Category: Endocrinology Source Type: research

The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility in an Iranian cohort
Abstract Purpose The study was aimed at investigating the association between hsa-mir-27a polymorphism rs895819 (T/C) and type 2 diabetes mellitus (T2DM) susceptibility in a large Iranian cohort. Methods In this case–control study, the investigated population consisted of T2DM patients (n = 204) and sex- and age-matched controls (n = 209). We used the polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) for genotyping. Results We observed significant diff...
Source: Journal of Endocrinological Investigation - June 14, 2016 Category: Endocrinology Source Type: research

Effects of nutraceuticals on quality of life and sexual function of perimenopausal women
Abstract Purpose The aim of the study was to evaluate the effects of nutraceuticals containing Equol, Resveratrol, Quecitine and Passiflora (Zemiar®, Avantgarde, Pomezia, Rome, Italy) on quality of life (QoL) and sexual function in perimenopausal women. Methods Sixty perimenopausal women having vasomotor symptoms and being in the −1, +1a of the STRAW system (amenorrhea for longer than 60 days and FSH 
Source: Journal of Endocrinological Investigation - June 14, 2016 Category: Endocrinology Source Type: research

Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment
Conclusions AMH can be considered as an indicator of fertility in late reproductive age women and pregnancy outcome in assisted reproductive technology cycles. AMH can strongly predict poor response in the controlled ovarian stimulation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 14, 2016 Category: Endocrinology Source Type: research

Gender identity, gender assignment and reassignment in individuals with disorders of sex development: a major of dilemma
Conclusions Given the complexity of this management, DSD individuals and their families need to be supported by a specialized multidisciplinary team, which has been universally recognized as the best practice for intersexual conditions. In case of juvenile GD in DSD, the prescription of gonadotropin-releasing hormone analogues, following the World Professional Association for Transgender Health and the Endocrine Society guidelines, should be considered. It should always be taken into account that every DSD person is unique and has to be treated with individualized care. In this perspective, international registri...
Source: Journal of Endocrinological Investigation - June 10, 2016 Category: Endocrinology Source Type: research

Head-to-head comparison between flash and continuous glucose monitoring systems in outpatients with type 1 diabetes
Conclusions In outpatients with type 1 diabetes, we found good agreement between the FSL and DG4P. No significant difference was detected in the estimation of clinical diagnostic parameters. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 10, 2016 Category: Endocrinology Source Type: research

Saint Wilgefortis: sudden hirsutism to prevent an unwanted marriage
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 8, 2016 Category: Endocrinology Source Type: research

The “Lost Caravaggio”: a probable case of goiter in seventeenth-century Italy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 8, 2016 Category: Endocrinology Source Type: research

Key genes and pathways predicted in papillary thyroid carcinoma based on bioinformatics analysis
Conclusions DEGs of C3, PPARG, PAX8, JUN and MMP9 were differentially expressed in PTC samples and may be used as potential biomarkers in the diagnosis and treatment of PTC. Additionally, pathways of complement and coagulation cascades and thyroid cancer may also play important roles in the development of PTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 1, 2016 Category: Endocrinology Source Type: research

Recurrence of hyperprolactinemia following dopamine agonist withdrawal and possible predictive factors of recurrence in prolactinomas
Conclusions The study provides additional evidence that prolonging therapy for more than 3 years does not reduce recurrence rate. In particular, recurrence risk was similar in micro- and macroadenomas, and higher in patients with pituitary deficits at diagnosis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 31, 2016 Category: Endocrinology Source Type: research

Testosterone supplementation and body composition: results from a meta-analysis of observational studies
Conclusions Present data support the view of a positive effect of TS on body composition and on glucose and lipid metabolism. In addition, a significant effect on body weight loss was observed, which should be confirmed by a specifically designed RCT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 30, 2016 Category: Endocrinology Source Type: research

Supra-physiological rhGH administration induces gender-related differences in the hypothalamus–pituitary–thyroid (HPT) axis in healthy individuals
Abstract Purpose The use of recombinant human growth hormone (rhGH) is a common habit among athletes. While the effects of rhGH administration have been described with contrasting results in males, no data exist in females to date. The aim of the present study was to evaluate the effects of rhGH administration on TSH, FT4 and FT3 levels and the time requested to return to baseline values after treatment withdrawal. Methods Twenty-one healthy trained male and female athletes were treated with 0.03 mg rhGH/kg body mass 6 days/week for 3 week...
Source: Journal of Endocrinological Investigation - May 26, 2016 Category: Endocrinology Source Type: research

Effects and safety of combination therapy with gonadotropin-releasing hormone analogue and growth hormone in girls with idiopathic central precocious puberty: a meta-analysis
Conclusion For ICPP girls, the GnRHa and GH combination therapy had advantages over GnRHa alone on final height and no severe adverse effects were reported. We recommend comprehensive assessment of the individual growth rate, patient compliance, the clinical effects, the height expectations of individual patients and the treatment cost to the family in order to identify the best therapy for individual patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 25, 2016 Category: Endocrinology Source Type: research

Relation between therapy options for Graves’ disease and the course of Graves’ ophthalmopathy: a systematic review and meta-analysis
Abstract Background The relation between therapy options for Graves’ disease (GD) and the course of Graves’ ophthalmopathy (GO) are still controversial. Our aim was to compare the occurrence of development or worsening of GO in patients who were treated with antithyroid drugs (ATDs) or radioactive iodine (RAI) or thyroidectomy (TX). Methods We conducted a comprehensive search of the Embase and PubMed database. Odds ratio (OR) was used as a measure of the effect of therapy options for GD on the risk of development or worsening of GO. The analy...
Source: Journal of Endocrinological Investigation - May 24, 2016 Category: Endocrinology Source Type: research

Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic–pituitary–gonadal, hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes dysfunction
Abstract Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestations, such as weight gain, fatigue, low muscle strength, bradipsychism, hypotension or intolerance to cold. In these circumstances, hypopituitarism is a rarely life-threatening condition, but evolution may be more dramatic as a result of pituitary apoplexy, or when a serious condition of a...
Source: Journal of Endocrinological Investigation - May 21, 2016 Category: Endocrinology Source Type: research

Safety of total thyroid ablation in patients with Graves’ orbitopathy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 20, 2016 Category: Endocrinology Source Type: research

Masked hypertension in newly diagnosed hypothyroidism: a pilot study
Conclusions Hypothyroidism may be an important predictor of higher BP values, with an increased risk of MH. Because MH is a cardiovascular risk and can be reversed by thyroid hormone replacement, its presence should represent an indication for thyroid hormone replacement therapy also in patients with s-HYPO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 19, 2016 Category: Endocrinology Source Type: research

Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies
Abstract Purpose TSH-receptor (TSHR) antibodies (Ab) can be measured with binding or bio-assays. Sensitivity and specificity of five binding and two bio-assays were compared. Methods TSHR-blocking (TBAb) and TSHR-stimulating (TSAb) Ab were measured with reporter bio-assays. Blocking activity was defined as percent inhibition of luciferase expression relative to induction with bTSH alone. TSAb was reported as percentage of specimen-to-reference ratio (SRR%). TSHR-binding inhibitory immunoglobulins (TBII) were measured with Kronus, Dynex, Kryptor, Cobas, a...
Source: Journal of Endocrinological Investigation - May 19, 2016 Category: Endocrinology Source Type: research

Epigenetics: spotlight on type 2 diabetes and obesity
Abstract Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity. (S...
Source: Journal of Endocrinological Investigation - May 14, 2016 Category: Endocrinology Source Type: research

Positive correlation of serum HDL cholesterol with blood mercury concentration in metabolic syndrome Korean men (analysis of KNANES 2008–2010, 2013)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 13, 2016 Category: Endocrinology Source Type: research

Controversies in the management of Graves’ disease in children
Abstract Graves’ disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PTU) had been used in the past, only methimazole (MMI) should be now used in children, as PTU is associated with an unacceptable risk of liver failure. However, MMI may be associated minor and major side effects, which may be minimized using lower doses. An area of controversy involves th...
Source: Journal of Endocrinological Investigation - May 6, 2016 Category: Endocrinology Source Type: research

Usefulness of an ad hoc questionnaire (Acro-CQ) for the systematic assessment of acromegaly comorbidities at diagnosis and their management at follow-up
Conclusions Acro-CQ is an inexpensive, highly accepted from patients and reliable tool recommended to expedite systematic collection of relevant clinical data in acromegaly at diagnosis, to be replicated at follow-ups. This tool may guide a targeted, cost-effective management of complications. Moreover, it could be applied to retrieve data for survey studies in both acromegaly and other pituitary adenomas, as information is easily and rapidly accessible for statistical analysis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2016 Category: Endocrinology Source Type: research

Absence of TERT promoter mutations in pituitary adenomas
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2016 Category: Endocrinology Source Type: research

Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome
Abstract Purpose Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients. Methods A case-control study was performed in a training and research hospital. Eighty patients w...
Source: Journal of Endocrinological Investigation - May 4, 2016 Category: Endocrinology Source Type: research

Surgical management of papillary thyroid carcinoma in childhood and adolescence: an Italian multicenter study on 250 patients
Conclusion Pediatric patients are likely to benefit from a tailored surgical strategy. Uniformly offering patients total thyroidectomy seems to be an overly radical approach. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 29, 2016 Category: Endocrinology Source Type: research

Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study
The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR study. Methods PREDATORR was an epidemiological study with a stratified, cross-sectional, cluster random sampling design. Participants were classified into four cardiometabolic phenotypes based on the BMI, the cut-off value being 25 kg/m2, and the presence of MetS (define...
Source: Journal of Endocrinological Investigation - April 28, 2016 Category: Endocrinology Source Type: research

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children
Abstract Purpose The effect of growth hormone (GH) on adipose tissue and the role of adipokines in modulating metabolism are documented, but with discordant data. Our aim was to evaluate the impact of GH treatment on a series of selected adipokines known to have a metabolic role and poorly investigated in this setting. Methods This is a prospective study. Thirty-one prepubertal children (25 M, 6 F; aged 8.5 ± 1.6 years) with isolated GH deficiency treated with GH for at least 12 months and 30 matched controls were evaluate...
Source: Journal of Endocrinological Investigation - April 28, 2016 Category: Endocrinology Source Type: research

Positive correlation of serum HDL cholesterol with blood mercury concentration in metabolic syndrome Korean men (analysis of KNANES 2008–2010, 2013)
Conclusion Serum HDLC was positively associated with blood mercury concentration in MS Korean men. Therefore, elevated blood mercury may be a factor to increase serum HDLC concentration in MS men. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 23, 2016 Category: Endocrinology Source Type: research

Radiofrequency ablation for benign thyroid nodules
Abstract Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occur...
Source: Journal of Endocrinological Investigation - April 20, 2016 Category: Endocrinology Source Type: research

Exophthalmos (Graves’ orbitopathy) in an ancient sculpture
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2016 Category: Endocrinology Source Type: research

Intracellular retention of thyroglobulin in the absence of the low-density lipoprotein receptor-associated protein (RAP) is likely due to premature binding to megalin in the biosynthetic pathway
Conclusions The intracellular retention of Tg in the absence of RAP is likely due to its premature interaction with megalin, whereas RAP does not seem to affect Tg secretion directly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 19, 2016 Category: Endocrinology Source Type: research

SIAD: practical recommendations for diagnosis and management
Abstract Hyponatremia is the commonest electrolyte disturbance encountered in hospitalized patients, and the syndrome of inappropriate antidiuresis (SIAD) is the most frequent underlying disorder. There is a well-recognized relationship between hyponatremia and increased morbidity and mortality. Therefore, to provide appropriate treatment is critical to improve the clinical outcome related to SIAD-hyponatremia. There have been important advances in the treatment of SIAD over the last decade, leading to the publication of several clinical guidelines. In particular, the introduction of the vasopressin-2 receptor ant...
Source: Journal of Endocrinological Investigation - April 19, 2016 Category: Endocrinology Source Type: research

Effects of crocin and voluntary exercise, alone or combined, on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats
Abstract Background Hyperglycemia is the main risk factor for microvascular complications in type 2 diabetes. Crocin and voluntary exercise have anti-hyperglycemic effects in diabetes. In this research, we evaluated the effects of crocin and voluntary exercise alone or combined on glycemia control and heart level of VEGF-A. Materials and methods Animals were divided into eight groups as: control (con), diabetes (Dia), crocin (Cro), voluntary exercise (Exe), crocin and voluntary exercise (Cro-Exe), diabetic–crocin (Dia-Cro), diabetic–voluntary...
Source: Journal of Endocrinological Investigation - April 19, 2016 Category: Endocrinology Source Type: research

Premature ovarian insufficiency: the context of long-term effects
Conclusions In conclusion there are several well-characterized health risks in POI women. With every patient, an individualized approach is required to properly recognize and prevent these risks. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2016 Category: Endocrinology Source Type: research

Role of “old” pharmacological agents in the treatment of Cushing’s syndrome
Abstract Despite recent advances in the management of endogenous Cushing’s syndrome (CS), its treatment remains a challenge. When surgery has been unsuccessful or unfeasible as well in case of recurrence, the “old” pharmacological agents represent an important alternative for both ACTH-dependent and independent hypercortisolism. Especially in the latter, the advent of novel molecules directly targeting ACTH secretion has not outweighed the “old” drugs, which continue to be largely employed and have recently undergone a reappraisal. This review provides a survey of the “old&rdquo...
Source: Journal of Endocrinological Investigation - April 16, 2016 Category: Endocrinology Source Type: research

Varicocele and concomitant dilation of the periprostatic venous plexus: effects on semen viscosity sperm parameters
Conclusions In conclusion, these results showed that a large number of patients with varicocele had a concomitant DPVP. This subset of patients did not take advantage from varicocele surgical repair since only DPVP− varicocele patients showed a significant improvement of sperm progressive motility and seminal fluid viscosity. These findings suggest the evaluation of the periprostatic venous plexus and seminal fluid viscosity before patients with varicocele undergo surgical repair for asthenozoospemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 13, 2016 Category: Endocrinology Source Type: research

Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients
Conclusions Reduction of APPL1, insulin receptor and adiponectin system genes in GCs could be involved in the development of PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 13, 2016 Category: Endocrinology Source Type: research