Controversies in the management of Graves ’ disease in children
AbstractGraves ’ disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PTU) had been used in the past, only methimazole (MMI) should be now used in children, as PTU is associated with an unacceptable risk of liver failure. However, MMI may be associated minor and major side effects, which may be minimized using lower doses. An area of controversy involves the optimal...
Source: Journal of Endocrinological Investigation - October 19, 2016 Category: Endocrinology Source Type: research

Relation between therapy options for Graves ’ disease and the course of Graves’ ophthalmopathy: a systematic review and meta-analysis
AbstractBackgroundThe relation between therapy options for Graves ’ disease (GD) and the course of Graves’ ophthalmopathy (GO) are still controversial. Our aim was to compare the occurrence of development or worsening of GO in patients who were treated with antithyroid drugs (ATDs) or radioactive iodine (RAI) or thyroidectomy (TX).MethodsWe conducted a comprehensive search of the Embase and PubMed database. Odds ratio (OR) was used as a measure of the effect of therapy options for GD on the risk of development or worsening of GO. The analysis was further stratified by factors that could affect the treatment eff...
Source: Journal of Endocrinological Investigation - October 19, 2016 Category: Endocrinology Source Type: research

Fertility in women of late reproductive age: the role of serum anti-M üllerian hormone (AMH) levels in its assessment
Conclusions AMH can be considered as an indicator of fertility in late reproductive age women and pregnancy outcome in assisted reproductive technology cycles. AMH can strongly predict poor response in the controlled ovarian stimulation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 19, 2016 Category: Endocrinology Source Type: research

Effects of daily tadalafil on lower urinary tract symptoms in young men with multiple sclerosis and erectile dysfunction: a pilot study
AbstractPurposeMen affected by multiple sclerosis often experience neurogenic overactive bladder (OAB), lower urinary tract symptoms and erectile dysfunction (ED). The aim of the study was to investigate modifications of urinary and sexual functions after administration of daily tadalafil (TAD) 5  mg.MethodsTwenty men were enrolled in a single-blind, 4-week prospective study while 10 men without treatment served as controls. Primary outcomes were changes from baseline of International Prostate Symptom (IPSS), OAB questionnaire (OAB-q-short form) and International Index of Erectile Function (IIEF-5) scores. To evaluate...
Source: Journal of Endocrinological Investigation - October 16, 2016 Category: Endocrinology Source Type: research

Follow-up of patients with adrenal incidentaloma, in accordance with the European society of endocrinology guidelines: Could we be safe?
AbstractRecently, the European Society of Endocrinology (ESE) published new guidelines on the management of adrenal incidentalomas. At the same time Lopez and coworkers published on the Annals of Internal Medicine an important study showing that even patients with non-functioning adrenal tumors have an increased risk of incident diabetes. In consideration of previous data and of the results of the study of Lopez and coworkers, some points emerge from the ESE Guidelines that deserve attention. Firstly, it must be observed that the term “autonomous cortisol secretion,” introduced by the ESE Panel in the place of ...
Source: Journal of Endocrinological Investigation - October 14, 2016 Category: Endocrinology Source Type: research

In remembrance of Professor Loredana Gandini (1957 –2016)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 13, 2016 Category: Endocrinology Source Type: research

Secondary hyperparathyroidism prevalence and prognostic role in elderly males with heart failure
AbstractAimEvaluation of secondary hyperparathyroidism (SHPT) and its prognostic impact on all-cause mortality in elderly males with heart failure (HF).MethodsSeventy three males (67  ± 7 years old) with systolic HF were included. Baseline PTH was measured. Patients were grouped according to PTH cut-off levels of 65 pg/ml (>65  pg/ml = SHPT vs. normal PTH). All-cause mortality was evaluated at 6-year follow-up.ResultsSHPT was diagnosed in 43 (59  %) patients. They were more severe compared to the patients with normal PTH regarding NYHA functional class (2.4 ±&nb...
Source: Journal of Endocrinological Investigation - October 12, 2016 Category: Endocrinology Source Type: research

Subclinical hypothyroidism and diabetic nephropathy in Iranian patients with type 2 diabetes
ConclusionsWe found that the prevalence of subclinical hypothyroidism in Iranian diabetic population was among the highest rates reported to date. Our data supported the independent association of subclinical hypothyroidism with diabetic nephropathy, calling for further investigations to evaluate their longitudinal associations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 12, 2016 Category: Endocrinology Source Type: research

Effects of selenium on short-term control of hyperthyroidism due to Graves ’ disease treated with methimazole: results of a randomized clinical trial
ConclusionsOur study, carried out in a selenium-sufficient cohort of GD patients, failed to show an adjuvant role of selenium in the short-term control of hyperthyroidism. However, selenium might be beneficial in patients from selenium-deficient areas, as well as in the long-term outcome of antithyroid treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 11, 2016 Category: Endocrinology Source Type: research

How the reference values for serum parathyroid hormone concentration are (or should be) established?
AbstractWell-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria for this population can be defined as any situation possibly inducing an increase or a decrease in PTH concentration. As recommended in the recent guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism, PTH reference values should be established in vitamin D-replete subjects with a normal renal function with possible stratification according to various factors such as age, gender, m...
Source: Journal of Endocrinological Investigation - September 30, 2016 Category: Endocrinology Source Type: research

Pituitary function within the first year after traumatic brain injury or subarachnoid haemorrhage
ConclusionsPerturbations in pituitary function continue to occur during the first year after TBI and SAH, but only a few patients need replacement therapy. Our study could not identify a marker of increased risk of pituitary dysfunction that could guide routine screening. However, data demonstrate the need for systematic follow-up of pituitary function after moderate or severe TBI or SAH. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 25, 2016 Category: Endocrinology Source Type: research

Cross-cultural and socio-demographic correlates of homophobic attitude among university students in three European countries
ConclusionsThis study revealed that in these European countries assessed, attitudes toward homosexuality are different. Ukrainians display higher levels of homophobia than Albanians and Italians, confirming the central role of cultural differences in homophobic attitudes. Nevertheless, some socio-demographic aspects such as identification as male have a similar influence on homophobic attitudes in all assessed populations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 24, 2016 Category: Endocrinology Source Type: research

Follicular fluid PlGF/sFlt - 1 ratio and soluble receptor for advanced glycation end –products correlate with ovarian sensitivity index in women undergoing A.R.T.
AbstractPurposeConsidering potential roles of soluble receptor for advanced glycation end products (sRAGE) and placental growth factor (PlGF) in ovarian function and embryo implantation, in the present study we have evaluated the association of these factors and also PlGF/sFlt-1 ratio with the ovarian response and implantation rate by dividing patients according to the OSI.MethodsIn a cross-sectional study, 90 infertile women who were undergoing ICSI cycle using long protocol were recruited. The patients were divided according to ovarian sensitivity index (OSI). ICSI cycle outcomes were evaluated for each patient and PlGF,...
Source: Journal of Endocrinological Investigation - September 22, 2016 Category: Endocrinology Source Type: research

Natural course of mild Graves ’ orbitopathy: is it a chronic remitting or a transient disease?
ConclusionsThe question whether mild GO is a remitting, albeit chronic disease, or even a transient event in the course of Graves ’ disease, remains currently unanswered. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 22, 2016 Category: Endocrinology Source Type: research

Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism
AbstractKlinefelter Syndrome (KS) is characterized by an extreme heterogeneity in its clinical and genetic presentation. The relationship between clinical phenotype and genetic background has been partially disclosed; nevertheless, physicians are aware that several aspects concerning this issue are far to be fully understood. By improving our knowledge on the role of some genetic aspects as well as on the KS, patients ’ interindividual differences in terms of health status will result in a better management of this chromosomal disease. The aim of this review is to provide an update on both genetic and clinical phenot...
Source: Journal of Endocrinological Investigation - September 18, 2016 Category: Endocrinology Source Type: research

Who has the worst attitudes toward sexual minorities? Comparison of transphobia and homophobia levels in gender dysphoric individuals, the general population and health care providers
AbstractPurpose To date, few studies have addressed attitudes toward transgender individuals. In addition, little is known about health care providers ’ (HCP) attitudes toward sexual minorities. The aim of the present study is to compare attitudes toward homosexual and transgender individuals between gender dysphoric individuals (GDs), general population controls (C) and HCP.Methods A total of 310 subjects were considered, including 122 GDs (63 transwomen and 59 transmen), 53 heterosexual HCP (26 males and 27 females) and 135 C. Participants completed the Modern Homophobia Scale (MHS) and the Attitudes Toward Tra...
Source: Journal of Endocrinological Investigation - September 16, 2016 Category: Endocrinology Source Type: research

Effects of high-intensity interval training on physical capacities and substrate oxidation rate in obese adolescents
AbstractPurposeTo investigate the effects of a 3-week weight-management program entailing moderate energy restriction, nutritional education, psychological counseling and three different exercise training (a: low intensity, LI: 40  % V′O2max; b: high intensity, HI: 70  % V′O2max; c: high-intensity interval training, HIIT), on body composition, energy expenditure and fat oxidation rate in obese adolescents.MethodsThirty obese adolescents (age: 15 –17 years, BMI: 37.5 kg m−2) participated in this study. Before starting (week 0, W0) and at the end of the weight-management progr...
Source: Journal of Endocrinological Investigation - September 16, 2016 Category: Endocrinology Source Type: research

Adipokines and bone metabolism: an interplay to untangle
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 16, 2016 Category: Endocrinology Source Type: research

Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic –pituitary–gonadal, hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes dysfunction
Abstract Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestations, such as weight gain, fatigue, low muscle strength, bradipsychism, hypotension or intolerance to cold. In these circumstances, hypopituitarism is a rarely life-threatening condition, but evolution may be more dramatic as a result of pituitary apoplexy, or when a serious condition of adrenal insu...
Source: Journal of Endocrinological Investigation - September 15, 2016 Category: Endocrinology Source Type: research

Management of hyperthyroidism due to Graves ’ disease: frequently asked questions and answers (if any)
Abstract Graves ’ disease is the most common cause of hyperthyroidism in iodine-replete areas. Although progress has been made in our understanding of the pathogenesis of the disease, no treatment targeting pathogenic mechanisms of the disease is presently available. Therapies for Graves’ hyperthyroidism are la rgely imperfect because they are bound to either a high rate of relapsing hyperthyroidism (antithyroid drugs) or lifelong hypothyroidism (radioiodine treatment or thyroidectomy). Aim of the present article is to offer a practical guidance to the reader by providing evidence-based answers to frequent ly...
Source: Journal of Endocrinological Investigation - September 15, 2016 Category: Endocrinology Source Type: research

Safety of total thyroid ablation in patients with Graves ’ orbitopathy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 15, 2016 Category: Endocrinology Source Type: research

Judith and her Maidservant: a goitrous heroin in two masterpieces
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 13, 2016 Category: Endocrinology Source Type: research

The treatment of hyperinsulinemic hypoglycaemia in adults: an update
ConclusionsNew approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local –regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 12, 2016 Category: Endocrinology Source Type: research

Breast cancer and thyroid diseases: analysis of 867 consecutive cases
AbstractIntroductionThe aim of this study was to evaluate the association of breast cancer with thyroid diseases. Many authors have already studied the possible relationship between these two diseases, but the results are nowadays conflicting.Materials and methodsOur study examining 867 patients with breast cancer (862 women and 5 men, average age  = 61 years old) of whom 141 also had thyroid disease evaluated the recurrence of thyroid diseases and their association with different types of breast cancer. Statistical analyses were performed using SPSS software for Windows; we used nonparametric tests (Chi-squ...
Source: Journal of Endocrinological Investigation - September 12, 2016 Category: Endocrinology Source Type: research

A likely case of goiter in the Madonna col Bambino dormiente (1465/1470) by Andrea Mantegna (1431 –1506)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 12, 2016 Category: Endocrinology Source Type: research

Iodine deficiency a persisting problem: assessment of iodine nutrition and evaluation of thyroid nodular pathology in Portugal
ConclusionsThe findings of this first general population study on IN from the inland region of BI, Portugal, document significant ID. This problem, with its serious public health implications, could be corrected by having affordable iodised salt widely and generally available and by promoting a proactive population attitude generated by ample public information and educational programs as to the negative consequences of ID. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 11, 2016 Category: Endocrinology Source Type: research

Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator
ConclusionOur study provides evidence for an inverse association between circulating omentin-1 and BUA levels in postmenopausal women. However, the present findings do not support a mediating effect of OPG in the adipose tissue –bone pathway. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 9, 2016 Category: Endocrinology Source Type: research

Lactational exposure effect of polychlorinated biphenyl on rat Sertoli cell markers and functional regulators in prepuberal and puberal F 1 offspring
ConclusionLactational exposure to PCB affects both the histoarchitecture of testis, Sertoli cell maker and functional regulators in both prepuberal and puberal F1 male progeny. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 9, 2016 Category: Endocrinology Source Type: research

Sexual function in young women with type 1 diabetes: the METRO study
AbstractPurpose The aim of this study was to evaluate the prevalence and risk factors associated with female sexual dysfunction (FSD) in young women with type 1 diabetes treated with different intensive insulin regimens.MethodsType 1 diabetic women aged 18 –35 years were included in this study if they had stable couple relationship and no oral contraceptive use. All women were asked to complete the Female Sexual Function Index (FSFI) and other validated multiple-choice questionnaires assessing sexual-related distress (Female Sexual Distress Scale, FSDS), quality of life (SF-36 Health Survey), physical activity...
Source: Journal of Endocrinological Investigation - September 8, 2016 Category: Endocrinology Source Type: research

Impact of age on plasma vaspin concentration in a group of normal Chinese people
ConclusionVaspin level increased with ageing, independent of sex, indices of glucose metabolism, lipid profile and other markers of adiposity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 6, 2016 Category: Endocrinology Source Type: research

Is peritoneal dialysis causing a measurable burden of inflammatory and endothelial injury on top of metabolic syndrome?
The objective of the study was to investigate possible in between adipokines, inflammatory, endothelial and oxidative stress markers between MS patients and patients on PD.MethodsConcentrations of adipokines (leptin, resistin), inflammatory markers [interleukin-6 (IL-6), soluble tumor necrosis factor alpha receptor (sTNF-R), myeloperoxidase (MPO), monocyte chemoattractant protein 1 (MCP-1)] and endothelial markers [soluble intracellular adhesion molecule-1 (sICAM-1), soluble CD40 ligand (sCD40L)] were determined in 55 MS patients and 18 patients on PD, with flow cytometry, and visfatin concentration was measured with ELISA...
Source: Journal of Endocrinological Investigation - September 5, 2016 Category: Endocrinology Source Type: research

Impact of a walking program of 10,000 steps per day and dietary counseling on health-related quality of life, energy expenditure and anthropometric parameters in obese subjects
AbstractPurposeThe aim of this pilot study was to assess the impact of a physical activity program of walking 10,000 steps per day along with monthly dietary counseling on the body composition, biological parameters, resting energy expenditure (REE) and health-related quality of life (HRQoL) of obese individuals.MethodsThirty-five obese adults (26 women; age: 39.2  ± 13.4 years, body mass, BM: 104.1 ± 18.7 kg and body mass index, BMI: 38.3 ± 6.6 kg m−2) followed a walking program (instructions were provided so that the participants increase their walki...
Source: Journal of Endocrinological Investigation - September 5, 2016 Category: Endocrinology Source Type: research

High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells
ConclusionsCollectively, our results demonstrated for the first time that in thyroid cancer cells hydroxytyrosol promoted apoptosis at higher doses with respect to other cancer cells lines. Therefore, further studies will reveal the mechanisms by which thyroid cancer cells are more resistant to the proapoptotic effect exerted by hydroxytyrosol as well as the potential application as novel target therapeutic in thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 2, 2016 Category: Endocrinology Source Type: research

Fas/FasL gene polymorphism in patients with Hashimoto ’s thyroiditis in Turkish population
ConclusionsGene polymorphism of Fas and G allele frequency may play a role in the regulation of apoptosis in thyroid autoimmune disorders. There is a need for further studies to clarify the  genetic role of apoptosis in HT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 29, 2016 Category: Endocrinology Source Type: research

Comparison of coronary heart disease risk among four diagnostic definitions of metabolic syndrome
AbstractPurposeMetabolic syndrome (MetS) is now well known as one of the major risk factors for coronary heart disease (CHD). Currently, there are several methods used to define MetS. The aim of this study was to determine to what extent current MetS definition reflects CHD risk using the probability of CHD in 10  years based on Framingham risk score algorithms.MethodsA total of 7575 adults, aged 16 –93 years (2532 men and 5043 women), were recruited. We conducted a cross-sectional health survey in China using MetS criteria from four different definitions: modified National Cholesterol Education Program-Adu...
Source: Journal of Endocrinological Investigation - August 28, 2016 Category: Endocrinology Source Type: research

Influence of short-term selenium supplementation on the natural course of Hashimoto ’s thyroiditis: clinical results of a blinded placebo-controlled randomized prospective trial
AbstractBackgroundThe real efficacy of selenium supplementation in Hashimoto ’s thyroiditis (HT) is still an unresolved issue.ObjectivesWe studied the short-term effect ofl-selenomethionine on the thyroid function in euthyroid patients with HT. Our primary outcome measures were TSH, thyroid hormones, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) levels and thyroid echogenicity after 6  months ofl-selenomethionine treatment. The secondary outcome measure was serum CXCL10 levels.MethodsIn a placebo-controlled randomized prospective study, we have enrolled untreated euthyroid patients with HT. ...
Source: Journal of Endocrinological Investigation - August 28, 2016 Category: Endocrinology Source Type: research

Are extremely high progesterone levels still an issue in IVF?
AbstractBackgroundPremature luteinization of one or more developing follicles complicates 1 –2 % of controlled ovarian stimulation cycles for assisted reproduction. The management of this complication is controversial, with cycle cancellation likely representing the most commonly used strategy. The aim of this study was to evaluate the efficacy of the “freeze-all” policy—where the entire cohort of blastocysts is cryopreserved for subsequent frozen-thawed embryo transfer—in treating cases of premature luteinization.MethodsPatients experiencing premature luteinization during controlled ovar...
Source: Journal of Endocrinological Investigation - August 26, 2016 Category: Endocrinology Source Type: research

Ophthalmic clues to the endocrine disorders
ConclusionThe endocrinologists need to be aware of these ocular signs that help in the early diagnosis of the underlying disorder. A syndromic approach is essential in the diagnosis of endocrinopathy in patients presenting with ophthalmic features. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 26, 2016 Category: Endocrinology Source Type: research

Association between bone mineral density and nonalcoholic fatty liver disease in Korean adults
ConclusionsModerate or severe NAFLD exerted a detrimental effect on FN BMD in men. However, moderate or severe NAFLD had a positive effect on lumbar spine BMD in postmenopausal women. Potential sex-specific differences of the effect of NAFLD on BMD need to be elucidated further. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 24, 2016 Category: Endocrinology Source Type: research

Association between type 1, type 2 cytokines, diabetic autoantibodies and 25-hydroxyvitamin D in children with type 1 diabetes
ConclusionsIn type 1 diabetic children, deficient levels of 25(OH)D are associated with high levels of HbA1c, circulatory cytokines and antibody markers. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 18, 2016 Category: Endocrinology Source Type: research

Low levels of plasma galanin in obese subjects with hypertension
ConclusionsLow galanin levels were one of characters of obese patients with high blood pressure, and this levels may be taken as a novel biomarker to predict  the development of high blood pressure in obese patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 17, 2016 Category: Endocrinology Source Type: research

Classical point mutations of RET, BRAF and RAS oncogenes are not shared in papillary and medullary thyroid cancer occurring simultaneously in the same gland
ConclusionsTo our knowledge, this is the first study analyzing a possible involvement ofRET,BRAF andRAS oncogene mutations in PTC/MTC. These data clearly suggest that the classical activating mutations of the oncogenes commonly involved in the pathogenesis of PTC and MTC may not be responsible for their simultaneous occurrence. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 16, 2016 Category: Endocrinology Source Type: research

Exophthalmos (Graves ’ orbitopathy) in an ancient sculpture
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 16, 2016 Category: Endocrinology Source Type: research

Different expression of sodium –iodide importer (NIS) between lactating breast and thyroid tissues may be due to structural difference of thyroid-stimulating hormone receptor (TSHR)
Conclusion The lower expression of NIS in lactating breast may be due to the 173 AA deletion in the TSHR resulting the lower binding of TSH to the TSHR. For the first time, this finding may explain the reason of the lower NIS expression in lactating breast. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 15, 2016 Category: Endocrinology Source Type: research

Authors' reply
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 15, 2016 Category: Endocrinology Source Type: research

Sensitivity of assays for TSH-receptor antibodies
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 15, 2016 Category: Endocrinology Source Type: research

A case of thyroid cancer on the track of the radiofrequency electrode 30  months after percutaneous ablation
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 15, 2016 Category: Endocrinology Source Type: research

Hypothyroidism and hyponatremia: data from a series of patients with iatrogenic acute hypothyroidism undergoing radioactive iodine therapy after total thyroidectomy for thyroid cancer
ConclusionsIatrogenic acute hypothyroidism-related hyponatremia is uncommon. However, because of the significant reduction of [Na+] in the transition from euthyroidism to iatrogenic hypothyroidism, the value of pre[Na+] should be viewed as a parameter to be considered. Since it acts as an independent risk factor for the development of hyponatremia, patients with a pre[Na+] close to the lower limit of normal range may deserve a closer monitoring of [Na+]. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 8, 2016 Category: Endocrinology Source Type: research

Peripheral nervous system assessment in acromegaly patients under somatostatin analogue therapy
ConclusionOur findings emphasize the high prevalence of peripheral nervous system involvement in acromegaly patients under SSA therapy and importance of neurological evaluation of these patients. Early diagnosis and treatment of the disease may reduce the PNS involvement. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 1, 2016 Category: Endocrinology Source Type: research

The effect of glycaemic control in type 2 diabetic patients with subclinical hypothyroidism
Conclusion Our study shows that glycaemic control may bring some benefits to type 2 diabetic patients with SCH. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 29, 2016 Category: Endocrinology Source Type: research