Gender identity, gender assignment and reassignment in individuals with disorders of sex development: a major of dilemma
Conclusions Given the complexity of this management, DSD individuals and their families need to be supported by a specialized multidisciplinary team, which has been universally recognized as the best practice for intersexual conditions. In case of juvenile GD in DSD, the prescription of gonadotropin-releasing hormone analogues, following the World Professional Association for Transgender Health and the Endocrine Society guidelines, should be considered. It should always be taken into account that every DSD person is unique and has to be treated with individualized care. In this perspective, international registri...
Source: Journal of Endocrinological Investigation - June 9, 2016 Category: Endocrinology Source Type: research

Head-to-head comparison between flash and continuous glucose monitoring systems in outpatients with type 1 diabetes
Conclusions In outpatients with type 1 diabetes, we found good agreement between the FSL and DG4P. No significant difference was detected in the estimation of clinical diagnostic parameters. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 9, 2016 Category: Endocrinology Source Type: research

Saint Wilgefortis: sudden hirsutism to prevent an unwanted marriage
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 7, 2016 Category: Endocrinology Source Type: research

The “Lost Caravaggio”: a probable case of goiter in seventeenth-century Italy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 7, 2016 Category: Endocrinology Source Type: research

Key genes and pathways predicted in papillary thyroid carcinoma based on bioinformatics analysis
Conclusions DEGs of C3, PPARG, PAX8, JUN and MMP9 were differentially expressed in PTC samples and may be used as potential biomarkers in the diagnosis and treatment of PTC. Additionally, pathways of complement and coagulation cascades and thyroid cancer may also play important roles in the development of PTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 31, 2016 Category: Endocrinology Source Type: research

Recurrence of hyperprolactinemia following dopamine agonist withdrawal and possible predictive factors of recurrence in prolactinomas
Conclusions The study provides additional evidence that prolonging therapy for more than 3 years does not reduce recurrence rate. In particular, recurrence risk was similar in micro- and macroadenomas, and higher in patients with pituitary deficits at diagnosis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 30, 2016 Category: Endocrinology Source Type: research

Testosterone supplementation and body composition: results from a meta-analysis of observational studies
Conclusions Present data support the view of a positive effect of TS on body composition and on glucose and lipid metabolism. In addition, a significant effect on body weight loss was observed, which should be confirmed by a specifically designed RCT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 29, 2016 Category: Endocrinology Source Type: research

Supra-physiological rhGH administration induces gender-related differences in the hypothalamus–pituitary–thyroid (HPT) axis in healthy individuals
Abstract Purpose The use of recombinant human growth hormone (rhGH) is a common habit among athletes. While the effects of rhGH administration have been described with contrasting results in males, no data exist in females to date. The aim of the present study was to evaluate the effects of rhGH administration on TSH, FT4 and FT3 levels and the time requested to return to baseline values after treatment withdrawal. Methods Twenty-one healthy trained male and female athletes were treated with 0.03 mg rhGH/kg body mass 6 days/week for 3 week...
Source: Journal of Endocrinological Investigation - May 25, 2016 Category: Endocrinology Source Type: research

Effects and safety of combination therapy with gonadotropin-releasing hormone analogue and growth hormone in girls with idiopathic central precocious puberty: a meta-analysis
Conclusion For ICPP girls, the GnRHa and GH combination therapy had advantages over GnRHa alone on final height and no severe adverse effects were reported. We recommend comprehensive assessment of the individual growth rate, patient compliance, the clinical effects, the height expectations of individual patients and the treatment cost to the family in order to identify the best therapy for individual patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 24, 2016 Category: Endocrinology Source Type: research

Relation between therapy options for Graves’ disease and the course of Graves’ ophthalmopathy: a systematic review and meta-analysis
Abstract Background The relation between therapy options for Graves’ disease (GD) and the course of Graves’ ophthalmopathy (GO) are still controversial. Our aim was to compare the occurrence of development or worsening of GO in patients who were treated with antithyroid drugs (ATDs) or radioactive iodine (RAI) or thyroidectomy (TX). Methods We conducted a comprehensive search of the Embase and PubMed database. Odds ratio (OR) was used as a measure of the effect of therapy options for GD on the risk of development or worsening of GO. The analy...
Source: Journal of Endocrinological Investigation - May 23, 2016 Category: Endocrinology Source Type: research

Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic–pituitary–gonadal, hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes dysfunction
Abstract Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestations, such as weight gain, fatigue, low muscle strength, bradipsychism, hypotension or intolerance to cold. In these circumstances, hypopituitarism is a rarely life-threatening condition, but evolution may be more dramatic as a result of pituitary apoplexy, or when a serious condition of a...
Source: Journal of Endocrinological Investigation - May 20, 2016 Category: Endocrinology Source Type: research

Safety of total thyroid ablation in patients with Graves’ orbitopathy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 19, 2016 Category: Endocrinology Source Type: research

Masked hypertension in newly diagnosed hypothyroidism: a pilot study
Conclusions Hypothyroidism may be an important predictor of higher BP values, with an increased risk of MH. Because MH is a cardiovascular risk and can be reversed by thyroid hormone replacement, its presence should represent an indication for thyroid hormone replacement therapy also in patients with s-HYPO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 18, 2016 Category: Endocrinology Source Type: research

Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies
Abstract Purpose TSH-receptor (TSHR) antibodies (Ab) can be measured with binding or bio-assays. Sensitivity and specificity of five binding and two bio-assays were compared. Methods TSHR-blocking (TBAb) and TSHR-stimulating (TSAb) Ab were measured with reporter bio-assays. Blocking activity was defined as percent inhibition of luciferase expression relative to induction with bTSH alone. TSAb was reported as percentage of specimen-to-reference ratio (SRR%). TSHR-binding inhibitory immunoglobulins (TBII) were measured with Kronus, Dynex, Kryptor, Cobas, a...
Source: Journal of Endocrinological Investigation - May 18, 2016 Category: Endocrinology Source Type: research

Epigenetics: spotlight on type 2 diabetes and obesity
Abstract Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity. (S...
Source: Journal of Endocrinological Investigation - May 13, 2016 Category: Endocrinology Source Type: research

Positive correlation of serum HDL cholesterol with blood mercury concentration in metabolic syndrome Korean men (analysis of KNANES 2008–2010, 2013)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 12, 2016 Category: Endocrinology Source Type: research

Controversies in the management of Graves’ disease in children
Abstract Graves’ disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PTU) had been used in the past, only methimazole (MMI) should be now used in children, as PTU is associated with an unacceptable risk of liver failure. However, MMI may be associated minor and major side effects, which may be minimized using lower doses. An area of controversy involves th...
Source: Journal of Endocrinological Investigation - May 5, 2016 Category: Endocrinology Source Type: research

Usefulness of an ad hoc questionnaire (Acro-CQ) for the systematic assessment of acromegaly comorbidities at diagnosis and their management at follow-up
Conclusions Acro-CQ is an inexpensive, highly accepted from patients and reliable tool recommended to expedite systematic collection of relevant clinical data in acromegaly at diagnosis, to be replicated at follow-ups. This tool may guide a targeted, cost-effective management of complications. Moreover, it could be applied to retrieve data for survey studies in both acromegaly and other pituitary adenomas, as information is easily and rapidly accessible for statistical analysis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 5, 2016 Category: Endocrinology Source Type: research

Absence of TERT promoter mutations in pituitary adenomas
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 5, 2016 Category: Endocrinology Source Type: research

Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome
Abstract Purpose Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients. Methods A case-control study was performed in a training and research hospital. Eighty patients w...
Source: Journal of Endocrinological Investigation - May 3, 2016 Category: Endocrinology Source Type: research

Surgical management of papillary thyroid carcinoma in childhood and adolescence: an Italian multicenter study on 250 patients
Conclusion Pediatric patients are likely to benefit from a tailored surgical strategy. Uniformly offering patients total thyroidectomy seems to be an overly radical approach. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 28, 2016 Category: Endocrinology Source Type: research

Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study
The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR study. Methods PREDATORR was an epidemiological study with a stratified, cross-sectional, cluster random sampling design. Participants were classified into four cardiometabolic phenotypes based on the BMI, the cut-off value being 25 kg/m2, and the presence of MetS (define...
Source: Journal of Endocrinological Investigation - April 27, 2016 Category: Endocrinology Source Type: research

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children
Abstract Purpose The effect of growth hormone (GH) on adipose tissue and the role of adipokines in modulating metabolism are documented, but with discordant data. Our aim was to evaluate the impact of GH treatment on a series of selected adipokines known to have a metabolic role and poorly investigated in this setting. Methods This is a prospective study. Thirty-one prepubertal children (25 M, 6 F; aged 8.5 ± 1.6 years) with isolated GH deficiency treated with GH for at least 12 months and 30 matched controls were evaluate...
Source: Journal of Endocrinological Investigation - April 27, 2016 Category: Endocrinology Source Type: research

Positive correlation of serum HDL cholesterol with blood mercury concentration in metabolic syndrome Korean men (analysis of KNANES 2008–2010, 2013)
Conclusion Serum HDLC was positively associated with blood mercury concentration in MS Korean men. Therefore, elevated blood mercury may be a factor to increase serum HDLC concentration in MS men. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2016 Category: Endocrinology Source Type: research

Radiofrequency ablation for benign thyroid nodules
Abstract Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occur...
Source: Journal of Endocrinological Investigation - April 19, 2016 Category: Endocrinology Source Type: research

Exophthalmos (Graves’ orbitopathy) in an ancient sculpture
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 19, 2016 Category: Endocrinology Source Type: research

Intracellular retention of thyroglobulin in the absence of the low-density lipoprotein receptor-associated protein (RAP) is likely due to premature binding to megalin in the biosynthetic pathway
Conclusions The intracellular retention of Tg in the absence of RAP is likely due to its premature interaction with megalin, whereas RAP does not seem to affect Tg secretion directly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2016 Category: Endocrinology Source Type: research

SIAD: practical recommendations for diagnosis and management
Abstract Hyponatremia is the commonest electrolyte disturbance encountered in hospitalized patients, and the syndrome of inappropriate antidiuresis (SIAD) is the most frequent underlying disorder. There is a well-recognized relationship between hyponatremia and increased morbidity and mortality. Therefore, to provide appropriate treatment is critical to improve the clinical outcome related to SIAD-hyponatremia. There have been important advances in the treatment of SIAD over the last decade, leading to the publication of several clinical guidelines. In particular, the introduction of the vasopressin-2 receptor ant...
Source: Journal of Endocrinological Investigation - April 18, 2016 Category: Endocrinology Source Type: research

Effects of crocin and voluntary exercise, alone or combined, on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats
Abstract Background Hyperglycemia is the main risk factor for microvascular complications in type 2 diabetes. Crocin and voluntary exercise have anti-hyperglycemic effects in diabetes. In this research, we evaluated the effects of crocin and voluntary exercise alone or combined on glycemia control and heart level of VEGF-A. Materials and methods Animals were divided into eight groups as: control (con), diabetes (Dia), crocin (Cro), voluntary exercise (Exe), crocin and voluntary exercise (Cro-Exe), diabetic–crocin (Dia-Cro), diabetic–voluntary...
Source: Journal of Endocrinological Investigation - April 18, 2016 Category: Endocrinology Source Type: research

Premature ovarian insufficiency: the context of long-term effects
Conclusions In conclusion there are several well-characterized health risks in POI women. With every patient, an individualized approach is required to properly recognize and prevent these risks. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2016 Category: Endocrinology Source Type: research

Role of “old” pharmacological agents in the treatment of Cushing’s syndrome
Abstract Despite recent advances in the management of endogenous Cushing’s syndrome (CS), its treatment remains a challenge. When surgery has been unsuccessful or unfeasible as well in case of recurrence, the “old” pharmacological agents represent an important alternative for both ACTH-dependent and independent hypercortisolism. Especially in the latter, the advent of novel molecules directly targeting ACTH secretion has not outweighed the “old” drugs, which continue to be largely employed and have recently undergone a reappraisal. This review provides a survey of the “old&rdquo...
Source: Journal of Endocrinological Investigation - April 15, 2016 Category: Endocrinology Source Type: research

Varicocele and concomitant dilation of the periprostatic venous plexus: effects on semen viscosity sperm parameters
Conclusions In conclusion, these results showed that a large number of patients with varicocele had a concomitant DPVP. This subset of patients did not take advantage from varicocele surgical repair since only DPVP− varicocele patients showed a significant improvement of sperm progressive motility and seminal fluid viscosity. These findings suggest the evaluation of the periprostatic venous plexus and seminal fluid viscosity before patients with varicocele undergo surgical repair for asthenozoospemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 13, 2016 Category: Endocrinology Source Type: research

Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients
Conclusions Reduction of APPL1, insulin receptor and adiponectin system genes in GCs could be involved in the development of PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 12, 2016 Category: Endocrinology Source Type: research

Efficacy, safety and impact on β -cell function of dipeptidyl peptidase-4 inhibitors plus metformin combination therapy in patients with type 2 diabetes and the difference between Asians and Caucasians: a meta-analysis
Conclusion DPP-4 inhibitors and metformin therapy was effective and safe for T2DM patients. The glucose-lowering efficacy of DPP-4 inhibitors was same in Asian and Caucasian patients, although the effect on HOMA-β was inferior in Asian patients. The effect of DPP-4 inhibitors on HOMA-IR and body weight in Asian patients was comparable with that observed in Caucasian patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2016 Category: Endocrinology Source Type: research

Spironolactone and intermenstrual bleeding in polycystic ovary syndrome with normal BMI
Conclusions SP therapy can reduce the values of estradiol and the endometrial thickness in patients with PCOS compared with pretreatment, but PCOS patients with bleeding had pretreatment estradiol values lower than the patients who did not complain of this side effect. Intermenstrual abnormalities may represent the low estrogen impregnation of endometrium due to SP, whose mechanism is complex, involving several factors, such as the effects of some metabolites of SP on estradiol and progesterone production, on their receptors, and the individual metabolism of SP in vivo. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2016 Category: Endocrinology Source Type: research

Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB)
Conclusions The PDTA in thyroid surgery approved by the fourth consensus conference (June 2015) is the official PDTA of U.E.C. CLUB. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 7, 2016 Category: Endocrinology Source Type: research

Predictors and clinical consequences of starting androgen therapy in men with low testosterone: results from the SIAMO-NOI registry
Abstract Purpose Management of late onset hypogonadism (LOH) is not homogenous. The aim of the study is to observe the management of patients with low testosterone (T) in highly specialized Italian centres. Methods The SIAMO-NOI is an observational longitudinal disease registry for the evaluation of the clinical management of patients with low T levels (total T 
Source: Journal of Endocrinological Investigation - March 31, 2016 Category: Endocrinology Source Type: research

Comparative, open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 µg ethinyl estradiol continuous or 21/7 regimen oral contraceptive
Abstract Purpose To evaluate the effects of a continuous regimen combined oral contraceptive (COC) containing 2 mg dienogest and 30 µg ethinyl estradiol (DNG/EE) compared to a 21/7 regimen on the quality of life (QoL) and sexual function in women affected by endometriosis-associated pelvic pain. Methods Sixty-three women constituted the Study group treated with DNG/EE COC continuous regimen; 33 women were given DNG/EE COC in a 21/7 regimen. To define the endometriosis-associated pelvic pain, the Visual Analogic Scale was used. The Sho...
Source: Journal of Endocrinological Investigation - March 28, 2016 Category: Endocrinology Source Type: research

The relationship between visfatin and serum concentrations of C-reactive protein, interleukin 6 in patients with metabolic syndrome
Conclusion Serum visfatin was lower in patients with MS. Therefore it seems that visfatin could not be considered as a pro inflammatory adipocytokine in MS. The positive associations of obesity and visceral adiposity with elevated CRP and IL-6 levels suggest the importance of reducing visceral adiposity to prevent the risk of coronary disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 28, 2016 Category: Endocrinology Source Type: research

Association between serum adiponectin and HbA1c is independent of the severity of clinical presentation in young adults with new onset type 1 diabetes
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 24, 2016 Category: Endocrinology Source Type: research

Update on parathyroid carcinoma
Conclusions The treatment of choice is the en bloc resection of the tumor. The course of PC is variable; most patients have local recurrences or distant metastases and die from unmanageable hypercalcemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 21, 2016 Category: Endocrinology Source Type: research

The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes
Abstract Objective To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes. Methods A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matched controls) were included in the study. All patients were classified according to BMI levels (normal weight: NW, BMI
Source: Journal of Endocrinological Investigation - March 15, 2016 Category: Endocrinology Source Type: research

Meta-analysis of radiofrequency ablation for treating the local recurrence of thyroid cancers
Abstract Objectives Our aim was to evaluate the efficacy of ultrasound-guided radiofrequency ablation (RFA) for localized recurrent thyroid cancers. Methods We did a systematic review and meta-analysis of the scientific literature by searching the PubMed, Embase, Web of Science,Scopus and the Cochrane Library up to November 26, 2015. We assessed the pooled standard mean difference (SMD) of nodule volume, largest diameter and serum thyroglobulin (Tg) level by comparing pre-RFA with post-RFA using fixed or random-effects model. The Newcastle–Otta...
Source: Journal of Endocrinological Investigation - March 15, 2016 Category: Endocrinology Source Type: research

Hermaphroditism in Leonardo da Vinci’s Drawing “Angel in the Flesh” (1513–1515)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2016 Category: Endocrinology Source Type: research

A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome
Abstract Context Adropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including TNF-α. TNF-α regulates the secretion of certain peptides which play a crucial role in glucose and lipid homeostasis. There is also some evidence of a link between TNF-α and adropin. Objective To ascertain whether there i...
Source: Journal of Endocrinological Investigation - March 11, 2016 Category: Endocrinology Source Type: research

Italian association of clinical endocrinologists (AME) position statement: drug therapy of osteoporosis
Abstract Treatment of osteoporosis is aimed to prevent fragility fractures and to stabilize or increase bone mineral density. Several drugs with different efficacy and safety profiles are available. The long-term therapeutic strategy should be planned, and the initial treatment should be selected according to the individual site-specific fracture risk and the need to give the maximal protection when the fracture risk is highest (i.e. in the late life). The present consensus focused on the strategies for the treatment of postmenopausal osteoporosis taking into consideration all the drugs available for this purpose....
Source: Journal of Endocrinological Investigation - March 11, 2016 Category: Endocrinology Source Type: research

Consequences of hyperthyroidism in male and female fertility: pathophysiology and current management
Abstract Thyroid hormone acts on the oocytes, sperm and embryo during fertilization, implantation and placentation. Both hypothyroidism and hyperthyroidism may influence fertility. However, evidence of the association of hyperthyroidism with infertility is scarce and sometimes conflicting. Thyroid hormone influences human reproduction via a variety of mechanisms at both the central and the peripheral level. Infertility may occur in hyperthyroid men and women, but it is usually reversible upon restoration of euthyroidism. This review aims to summarize the available data on the association of hyperthyroidism and inf...
Source: Journal of Endocrinological Investigation - March 8, 2016 Category: Endocrinology Source Type: research

Endocrine dysfunction in hereditary hemochromatosis
Abstract Hereditary hemochromatosis (HH) is a genetic disorder of iron overload and subsequent organ damage. Five types of HH are known, classified by age of onset, genetic cause, clinical manifestations and mode of inheritance. Except for the rare form of juvenile haemochromatosis, symptoms do not usually appear until after decades of progressive iron loading and may be triggered by environmental and lifestyle factors. Despite the last decades discovery of genetic and phenotype diversity of HH, early studies showed a frequent involvement of the endocrine glands where diabetes and hypogonadism are the most common ...
Source: Journal of Endocrinological Investigation - March 7, 2016 Category: Endocrinology Source Type: research

Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency
Abstract Purpose I. R. Iran has been considered iodine replete since 2000, but iodine nutrition of vulnerable subjects is not clear. The main goal of this study was assessment of iodine nutrition and thyroid function in pregnant Iranian women. Methods A total of 1072 pregnant women from ten provinces in the different parts of the country were recruited from November to March 2014. Median urinary iodine concentration (UIC) as the measure of iodine status and serum free T4 (FT4), thyrotropin (TSH), thyroglobulin (Tg), anti-thyroglobulin and anti-thyroid pe...
Source: Journal of Endocrinological Investigation - March 7, 2016 Category: Endocrinology Source Type: research

The analysis of blood pressure profiles and their severity in relation to diabetic cardiovascular autonomic neuropathy in the Chinese population: preliminary analysis
Conclusion Our findings indicated that SBP and severity of BP profiles were significantly and independently associated with DCAN, respectively. These suggested BP profile may influence the progression of DCAN and also provided insight into biological functions. ClinicalTrials.gov Identifier NCT02461472. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 3, 2016 Category: Endocrinology Source Type: research