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Saint Augustine in his studio by Sandro Botticelli (1445 –1510): a representation of Hemochromatosis?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2024 Category: Endocrinology Source Type: research

HMGN1 down-regulation in the diabetic kidney attenuates tubular cells injury and protects against renal inflammation via suppressing MCP-1 and KIM-1 expression through TLR4
ConclusionsOur study provides novel insight into HMGN1 signaling mechanisms that contribute to tubular sterile injury and low-grade inflammation in DKD. The study findings may help to develop new HMGN1-targeted approaches as therapy for immune-mediated kidney damage rather than as an anti-infection treatments. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 27, 2024 Category: Endocrinology Source Type: research

An Italian real-world multicenter study of patients with advanced mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) of the gastro-entero-pancreatic system treated with chemotherapy
ConclusionThis study confirms that GEP-MiNENs represent a complex disease and that over the past years the clinical management has been predominantly guided by the subjective judgment of the clinicians. Although, in this series, the NEC component appeared mostly responsible for the systemic spread and prognosis on the whole neoplasm, the lack of strong prognostic and predictive factors universally recognized seems to condition their management so far. Future prospective clinical and biomolecular studies could help clinicians to improve clinical management of GEP-MiNENs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 24, 2024 Category: Endocrinology Source Type: research

Predicting postoperative hypocortisolism in patients with non-aldosterone-producing adrenocortical adenoma: a retrospective single-centre study
ConclusionsThe preoperative 1 mg dexamethasone suppression test cortisol value and presence of diabetes are the only relevant predictor of hypothalamus–pituitary–adrenal axis recovery in patients with non-aldosterone- producing adrenocortical adenoma undergoing surgery, regardless other clinical and biochemical variables. Notably, pre- and postoperative ACTH levels did not predict hypothalamus–pituitary–adrenal axis recovery. These findings point towards the potential for saving resources by optimizing their allocation during follow-up assessments for patients with non-aldosterone-producing adrenocortical adenoma...
Source: Journal of Endocrinological Investigation - February 22, 2024 Category: Endocrinology Source Type: research

Novel reference range values for serum testosterone: a cross-sectional study of 200,000 males
ConclusionsWe found significant variation in serum testosterone according to the presence of metabolic syndrome and time of laboratory draw, but not according to age. These data challenge the prior dogma of age-related hypogonadism and favor an individualized approach towards serum testosterone measurement and interpretation. However, further studies are needed to correlate these population-based data with individuals ’ hypogonadal symptoms. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 22, 2024 Category: Endocrinology Source Type: research

Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer
ConclusionsThyroid cancer exhibited enhanced glutamine metabolism, as evidenced by the glutamine dependence of thyroid cancer cells and high expression of multiple glutamine metabolism-related genes. Targeting glutamine metabolism with DON prodrug could be a promising therapeutic option for advanced thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 22, 2024 Category: Endocrinology Source Type: research

Transition from pediatric to adult care in patients with Turner syndrome in Italy: a consensus statement by the TRAMITI project
ConclusionsThe TRAMITI consensus statement provides valuable insights and evidence-based recommendations to guide healthcare practitioners in delivering comprehensive and patient-centered care for patients with TS. By addressing the complex medical and psychosocial aspects of the condition, this consensus aims to enhance TS management and improve the overall well-being and long-term outcomes of these individuals. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2024 Category: Endocrinology Source Type: research

Communication of the diagnosis to Klinefelter subjects: an observational study on a key moment of the patient ’s life
ConclusionTo mitigate the adverse effects of poorly timed and inadequately delivered communication, typically by a single person, it is advisable that such communication be carried out at the onset of adolescence by an interdisciplinary team of HCPs (including psychologists, geneticists, endocrinologists) and parents. The information provided should not solely concentrate on hormonal and fertility aspects, but also consider other factors such as psychological variables. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2024 Category: Endocrinology Source Type: research

Estimate and needs of the transgender adult population: the SPoT study
ConclusionsBeing TGD is not a marginal condition In Italy. A large proportion of TGD persons may not need medical and surgical treatments. TGD people often experience barriers to healthcare access relating to gender identity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 19, 2024 Category: Endocrinology Source Type: research