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Correlates of metabolic syndrome in people with chronic spinal cord injury
ConclusionIn people with chronic SCI, intense pain symptoms and poor LTPA may indicate a high likelihood of MetS, regardless of age, SCI duration, motor disability degree, insulin-sensitivity and comorbidities. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 29, 2024 Category: Endocrinology Source Type: research

Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis
ConclusionsNotch signal promotes the secretion of IL-17A from Th17 cells by regulating the downstream PI3K/AKT/mTORC1 pathway through Hes-Phosphatase and tensin homolog (PTEN) and participates in thyroid autoimmune damage, and the PI3K pathway inhibitor may play important effects on AIT by affecting Th17 cells differentiation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 29, 2024 Category: Endocrinology Source Type: research

Comments on TOBOGM study: treatment of gestational diabetes mellitus diagnosed early in pregnancy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 28, 2024 Category: Endocrinology Source Type: research

Ultrasound-based quantitative tools in predicting renal involvement in asymptomatic primary hyperparathyroidism
ConclusionThe use of ARFI imaging and RRI measurements appears to hold potential in identifying renal involvement in patients with aPHPT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 27, 2024 Category: Endocrinology Source Type: research

Are sonographic characteristics of Hashimoto ’s thyroiditis related with immunologic parameters? A cross-sectional study
ConclusionTOA, Ig G4 levels and severity of hypothyroidism were associated with ultrasonographic features such as parenchymal heterogeneity and fibrosis in Hashimoto ’s thyroiditis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 21, 2024 Category: Endocrinology Source Type: research

Gamma knife radiosurgery is effective in patients with thyrotropin-secreting pituitary adenomas
ConclusionOur study shows that GKRS is an effective and safe adjuvant treatment for selected patients with residual or recurring TSHoma. The option of GKRS as an alternative treatment to lifelong medical treatment with somatostatin analogs should be thoroughly discussed with the patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 20, 2024 Category: Endocrinology Source Type: research

Real-life data of Pasireotide LAR in acromegaly: a long-term follow-up
ConclusionIn real-life settings, PAS-LAR significantly decreases symptoms, IGF-1 levels, and the size of adenoma in patients with acromegaly resistant to SRLs. Beneficial effects may occur early after the first injection. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 20, 2024 Category: Endocrinology Source Type: research

Ketogenic nutritional therapy (KeNuT) —a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—diet therapies in endocrinology and metabolism
ConclusionThis practical guide will help the healthcare provider to acquire the necessary skills to provide a comprehensive care of patients with overweight, obesity and obesity-related diseases, using a multistep ketogenic dietary treatment, recognized by the Club of the Italian Society of Endocrinology (SIE) —Diet Therapies in Endocrinology and Metabolism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 18, 2024 Category: Endocrinology Source Type: research

A Delphi panel to build consensus on assessing disease severity and disease progression in adult patients with hypophosphatasia in the United States
ConclusionsThese statements regarding disease severity, progression, and assessment methods address some knowledge gaps in adult patients with HPP and may be helpful for treating HCPs, although the small sample size affects the ability to generalize the healthcare provider experience. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 18, 2024 Category: Endocrinology Source Type: research