PPAR- α inhibits DHEA-induced ferroptosis in granulosa cells through upregulation of FADS2
CONCLUSIONS: Our study indicates that PPAR-α may have an inhibitory effect on DHEA-induced ferroptosis in GCs by enhancing the expression of FADS2. This discovery provides valuable insights into the pathophysiology and potential therapeutic targets for PCOS.PMID:38678785 | DOI:10.1016/j.bbrc.2024.150005 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Ying Liu Feng Ni Jing Huang Yuqin Hu Jing Wang Xuemei Wang Xin Du Hong Jiang Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders
Eur J Med Chem. 2024 Apr 25;271:116405. doi: 10.1016/j.ejmech.2024.116405. Online ahead of print.ABSTRACTPARPi have been explored and applied in the treatment of various cancers with remarkable efficacy, especially BRCA1/2 mutated ovarian, breast, prostate, and pancreatic cancers. However, PARPi renders inevitable drug resistance and showed high toxicity because of PARP-Trapping with long-term clinic tracking. To overcome the drug resistance and the high toxicity of PARPi, many novel methods have been developed including PROTACs. Being an event-driven technology, PROTACs needs a high affinity, low toxicity warhead with no ...
Source: European Journal of Medicinal Chemistry - April 28, 2024 Category: Chemistry Authors: Xiaoyu Peng Yang Li Junfeng Qu Lizhi Jiang Kaiyue Wu Dan Liu Yuping Chen Junmei Peng Yu Guo Xuan Cao Source Type: research
Olaparib and niraparib as maintenance therapy in patients with newly diagnosed and platinum-sensitive recurrent ovarian cancer: A single-center study in China
CONCLUSIONS: Olaparib and niraparib were effective in patients with ovarian cancer without any new safety signals except for skin pigmentation. In patients with BRCAm, the 24-month PFS of the PARPi used in the PSR-M setting was even higher than that used in the FL-M setting.PMID:38679485 | DOI:10.1097/CM9.0000000000003125 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 28, 2024 Category: General Medicine Authors: Dengfeng Wang Xunwei Shi Jiao Pei Can Zhang Liping Peng Jie Zhang Jing Zheng Chunrong Peng Xiaoqiao Huang Xiaoshi Liu Hong Liu Guonan Zhang Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome
Biol Cell. 2024 Apr 28:e202300069. doi: 10.1111/boc.202300069. Online ahead of print.ABSTRACTPolycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are irregular menstrual cycle, acne in face, excess level of androgen (AE), insulin resistance, obesity, cardiovascular disease, mood disorder and type 2 diabetes (T2DM). PCOS may be caused by hormonal imbalance, genetic and epigenetic vulnerability, hypothalamic and ovarian troubles. PCOS is essentially hyperandrogen...
Source: Biology of the Cell - April 28, 2024 Category: Cytology Authors: Arifa Khatun Taslima Nasrin Md Samim Hassan Mehboob Hoque Muddasarul Hoda Safdar Ali Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
The relationship between religious affiliation and menopause symptoms and attitudes in United States women
Menopause a is key phase in female reproductive health and can result in bothersome symptoms. Natural menopause is defined as the permanent cessation of menstruation due to the loss of follicular activity in the ovaries, typically between the ages of 45 and 58 years [1]. Hot flashes and difficulty sleeping are commonly reported symptoms, and sexual dysfunction is a commonly reported diagnosis by women in this age group [2]. Hot flashes last an average of 7 years after natural menopause, but in some cases longer, and are characterized by a transient r ise in skin temperature and heart rate [2]. (Source: Maturitas)
Source: Maturitas - April 28, 2024 Category: Primary Care Authors: Annika Agarwal, Holly N. Thomas Tags: Original article Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
Targeting TtVgR via siRNA Knockdown Elicits Ovarian Cell Death in the Tri-spine Horseshoe Crab
In this study, we characterized a Tachypleus tridentatus vitellogenin receptor (TtVgR) gene from the tri-spine horseshoe crab, revealing a length of 1956 bp and encoding 652 amino acid residues with 12 exons. TtVgR has a molecular weight of 64.26 kDa and an isoelectric point of 5.95. Predictions indicate 85 phosphorylation sites and 7 glycosylation sites within TtVgR. Transcriptional analysis demonstrated specific expression of TtVgR in the ovary and yellow connective tissue. TtVgR was identified and distributed in the plasma membrane of oocytes. The siRNA-mediated TtVgR knockdown significantly reduced the transcriptional ...
Source: Marine Biotechnology - April 27, 2024 Category: Biotechnology Authors: Kianann Tan Xiaowan Ma Boyu Su Chen Zhan Xin Yang Khor Waiho Leong-Seng Lim Kit Yue Kwan Source Type: research
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells
This study reveals that human umbilical cord-derived MSCs (hUC-MSCs) can protect ovarian granulosa cells (GCs) from cyclophosphamide (CTX)-induced ferroptosis, a form of cell death driven by iron accumulation. CTX, commonly used to induce POI animal model, triggered ferroptosis in GCs, while hUC-MSCs treatment mitigated this effect, both in vivo and in vitro. Further investigations using ferroptosis and autophagy inhibitors suggest that hUC-MSCs act by suppressing ferroptosis in GCs. Interestingly, hUC-MSCs activate a protective antioxidant pathway in GCs via NRF2, a stress-response regulator. Overall, our findings suggest...
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Wenjie Dai Bo Xu Liyang Ding Zhen Zhang Hong Yang Tiantian He Ling Liu Xiuying Pei Xufeng Fu Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
