A case of mirror image agnosia and mirrored self-misidentification syndrome in schizophrenia without dementia or structural abnormalities.
Abstract Delusional misidentification syndrome (DMS) is an umbrella term encompassing a variety of disorders. One rare form of DMS is the delusional misidentification of one's own reflection, known as "mirrored self-misidentification syndrome". In "mirror image agnosia", the ability to identify the image of self and/or others in the mirror is lost, while the ability to identify the mirror itself is preserved. To our knowledge, mirror image agnosia has never been described in a patient with schizophrenia. Herein we present a case of a patient with schizophrenia with severe delusions of both mirr...
Source: Neurocase - July 29, 2020 Category: Neurology Authors: Rong C, Issac AG, Alkan ES, Fashina O, Ding K, Selek S Tags: Neurocase Source Type: research

A case of prosopometamorphopsia caused by infarction of the splenium of the corpus callosum and major forceps.
Abstract An adult female complained of enlargement of right eyes in other people. Diffusion-weighted imaging detected an abnormal high-intensity area in the region from the splenium of the corpus callosum to the major forceps on the right side. The patient reported that right eyes appeared larger in size, which suggested prosopometamorphopsia. Adichotic listening test identified left-ear deficit. Acombination of prosopometamorphopsia and left-ear deficit was not identified in the reported patients. Prosopometamorphopsia in most of the reported patients included the eye as did that in ...
Source: Neurocase - July 27, 2020 Category: Neurology Authors: Ogawa K, Akimoto T, Takahashi K, Hara M, Morita A, Kamei S, Nakajima H, Fujishiro M, Suzuki Y, Soma M, Shikata E, Futamura A, Kawamura M Tags: Neurocase Source Type: research

Selective impairment of On-reading (Chinese-style pronunciation) in alexia with agraphia for kanji due to subcortical hemorrhage in the left posterior middle temporal gyrus.
We report a patient with alexia with agraphia for kanji after hemorrhage in the left posterior middle temporal gyrus. The results of single-character kanji reading and two-character on- (Chinese-style pronunciation), kun- (native Japanese pronunciation), and Jukujikun (irregular kun-) reading word tests revealed that the patient could not read kanji characters with on-reading but read the characters with kun-reading. We consider that this on-reading alexia was caused by disconnection between the posterior inferior temporal cortex (orthographic lexicon) and the pos...
Source: Neurocase - July 16, 2020 Category: Neurology Authors: Yoshida M, Hayashi T, Fujii K, Ishiura H, Tsuji S, Sakurai Y Tags: Neurocase Source Type: research

Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia.
We report a patient presenting with clinical features of logopenic variant primary progressive aphasia (lvPPA) who was later diagnosed with probable dementia with Lewy bodies. LvPPA is a neurodegenerative disease that is characterized by anomia, word-finding difficulty, impaired comprehension, and phonological errors. The most common underlying pathology for lvPPA is Alzheimer's disease. However, our patient with clinical features of logopenic progressive aphasia was later diagnosed with probable dementia with Lewy bodies. This case demonstrates that lvPPA can also be an initial manifestation of a phenotype of dementia wit...
Source: Neurocase - July 16, 2020 Category: Neurology Authors: Boes S, Botha H, Machulda M, Lowe V, Graff-Radford J, Whitwell JL, Utianski RL, Duffy JR, Josephs KA Tags: Neurocase Source Type: research

Social cognition in an adult epilepsy patient with developmental amnesia.
We present the case of a 23-year-old male epilepsy patient, BM, with developmental amnesia due to perinatal cerebral hypoxia. The patient was examined with neuroimaging and neuropsychological methods and compared to IQ-matched patients with epilepsy to control for effects of epilepsy. In addition, we used a test battery that evaluates emotion recognition and theory of mind to study his social cognition abilities. Structural high-resolution magnetic resonance imaging showed bilateral hippocampal atrophy. The comparison to controls showed that, in addition to the well-documented memory disorders in developmental amnesia, BM ...
Source: Neurocase - July 12, 2020 Category: Neurology Authors: Bauer J, Grunwald T, Huppertz HJ, König K, Kohnen O, Shala J, Jokeit H Tags: Neurocase Source Type: research

Neuronal intranuclear inclusion disease presenting with dysphagia: a report of three cases.
Abstract Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease that is pathologically characterized by the presence of eosinophilic hyaline intranuclear inclusions in neurons, astrocytes, and specific somatic cells. Previously reported cases of NIID displayed various neurological symptoms, including dementia, muscle weakness, ataxia, etc. However, dysphagia associated with NIID have rarely been reported. Here, we report on three cases of NIID with dysphagia. Bolus mastication and transport were impaired in all three cases. Delay of the initiation of pharyngeal swallowing and silent asp...
Source: Neurocase - July 3, 2020 Category: Neurology Authors: Aoyagi Y, Taya M, Ohashi M, Saitoh E Tags: Neurocase Source Type: research

Pharyngeal dysesthesias as aura in epilepsy localized to the non-dominant frontal operculum misdiagnosed as non-epileptic seizures.
We report a rare case of isolated ictal pharyngeal dysesthesias localizing to the non-dominant frontal operculum lobe misdiagnosed as psychogenic and later confirmed by continuous video-EEG monitoring. PMID: 32615856 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - July 2, 2020 Category: Neurology Authors: Rini J, Ochoa J Tags: Neurocase Source Type: research

Of logos and men: semantic memory impairment for unique entities in a case of semantic variant of primary progressive aphasia.
In this study, an individual (NG) with the semantic varient of primary progressive aphasis (svPPA) was assessed with tasks designed to investigate the recognition and activation of semantic knowledge about unique entities. NG had significant difficulties in the recognition of brand names and famous names but was largely unimpaired in the recognition of logos and famous faces. However, she was impaired in tasks requiring the activation of semantic representations of logos, brand names, famous faces, and famous names. These results suggest that the recognition of unique entities results from the interaction of perceptual and...
Source: Neurocase - July 2, 2020 Category: Neurology Authors: Macoir J, Pilote-Paradis S, Lacoste L, Proulx M, Auclair-Ouellet N Tags: Neurocase Source Type: research

Longitudinal clinical, neuropsychological, and neuroimaging characterization of a kindred with a 12-octapeptide repeat insertion in PRNP: the next generation.
CONCLUSIONS AND RELEVANCE: Gene silencing treatments are on the horizon and when they become available, early detection will be crucial. Longitudinal studies involving familial mutation kindreds can offer important insights into the initial neuropsychological and neuroimaging changes necessary for early detection. PMID: 32602775 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - June 30, 2020 Category: Neurology Authors: Townley RA, Polsinelli AJ, Fields JA, Machulda MM, Jones DT, Graff-Radford J, Kantarci KM, Lowe VJ, Rademakers RV, Baker MC, Kumar N, Boeve BF Tags: Neurocase Source Type: research

Improved stability of long-duration sitting in spatial neglect after a single session of prism adaptation.
We present long-duration (5 min) CoP and trunk muscles electromyography recordings of a 61-year-old man with left-sided spatial neglect, before and after a single session of prism adaptation. His CoP-derived measures showed improved balance and postural stability in both the anterior-posterior and medial-lateral directions after prism adaptation. Concurrently, asymmetry in neuromuscular activations was reduced. The findings suggest that improved sitting balance may be associated with more symmetrical activation of trunk muscles after prism adaptation. PMID: 32600098 [PubMed - as supplied ...
Source: Neurocase - June 29, 2020 Category: Neurology Authors: Abdou A, Pilkar R, Chen P, Yue GH, Barrett AM Tags: Neurocase Source Type: research

From psychosis to Wernicke encephalopathy: a case of hunger strike in prison.
We present the case of a prisoner who commenced a hunger strike and developed WE. The preceding factors were associated with his oral intake refusal, which originated from his mental disorder with psychotic content. We discuss the clinical and treatment concerns for this complicated condition. PMID: 32589087 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - June 26, 2020 Category: Neurology Authors: Durmaz O, Aktaş S, Akkişi Kumsar N Tags: Neurocase Source Type: research

tDCS for auditory verbal hallucinations in a case of schizophrenia and left frontal lesion: efield simulation and clinical results.
m U Abstract Transcranial direct current stimulation (tDCS) has been explored for treatment of several neuropsychiatric disorders. For tDCS use in structural brain lesions there is some evidence from motor stroke rehabilitation and post-stroke depression. Here we report the application of tDCS in a woman previously diagnosed with schizophrenia presenting refractory auditory verbal hallucinations and left prefrontal tissue lesion. Treatment with 20 left fronto-temporal tDCS had no effect on psychiatric symptoms and neuropsychological evaluation. An ex-post electric field simulation and calculation of dorsolateral p...
Source: Neurocase - June 12, 2020 Category: Neurology Authors: Mezger E, Brunoni AR, Hasan A, Häckert J, Strube W, Keeser D, Padberg F, Palm U Tags: Neurocase Source Type: research

Degenerative dementia with proximal radial and lower vertical spatial neglect.
Abstract A 75 year-old man had a two-year history of progressive memory loss, trouble with finances and getting lost. On examination, he scored 16/30 in MoCA test, noticeably impaired on the attentional tasks. His screening bloodtests werenormal. Brain imaging revealed hippocampal atrophy and bilaterallarge areas of leukoaraiosis below posterior parietal lobes. On vertical line bisection he revealed a large upward bias and on radial bisection, a distal bias. Degeneration of his posterior parietal cortex may have caused both the leukoaraiosis and vertical-radial neglect. Unawareness of portions of space can be a so...
Source: Neurocase - June 5, 2020 Category: Neurology Authors: Pisanuwongrak K, Julayanont P, Heilman KM Tags: Neurocase Source Type: research

Unusual cortical symptoms of dural arteriovenous fistula mimicking transient ischemic attack.
Abstract The clinical presentation of dural arteriovenous fistula (DAVF) can vary. A 47-year-old man complained of transient difficulty playing badminton and speech disturbance for 10 minutes. His symptoms were suspected to be visuomotor coordination deficit similar to optic ataxia and anomic aphasia. Magnetic resonance imaging and angiography revealed vasogenic edema and perfusion delay in the left temporo-occipital area and an abnormal connection between the left occipital artery and transverse sinus. Transverse sinus DAVF was diagnosed by conventional cerebral angiography. We believe that this is the uniqu...
Source: Neurocase - June 3, 2020 Category: Neurology Authors: Lee S, Jung JH, Chung EJ, Seo JH Tags: Neurocase Source Type: research

Retained ability to extract gist in childhood-acquired amnesia: Insights from a single case.
Abstract This paper presents the performance of a young amnesic person (CJ) in the DRM task. CJ was found to be sensitive to the DRM manipulation at a level comparable to controls in recognition and at a level higher than controls in free recall. Detailed analyses of recall intrusions lent further support to the finding that CJ is able to extract gist on the basis of semantic associations. Results are discussed with reference to relevant theory as well as the potential role of an impaired and immature cognitive system in adopting a semantic gist strategy in the absence of episodic memory. PMID: 32420799 [PubM...
Source: Neurocase - May 18, 2020 Category: Neurology Authors: Pauly-Takacs K, Moulin CJA Tags: Neurocase Source Type: research

Do painters need their whole brain to excel?
The objective of this study is to asses the preserved artistry of a professional painter in spite of the presence of strokes affecting brain areas implicated in art expression. She had a neurologic evaluation and brain imaging after the stroke; painter-curators analyzed and compared the painter's pictorial artwork created before and after the stroke. In spite of cerebellar, visuospatial, motor, cognitive, and functional deficits likely related to strokes affecting bilateral cerebellar, left occipital, and right temporal-occipital areas, the patient was able to maintain most of their artistic painting skills.. After a short...
Source: Neurocase - May 18, 2020 Category: Neurology Authors: Fornazzari L, Haladyn J, Toledo T, Leggieri M, Friszberg I, Barfett J, Bharatha A, Munoz D, Schweizer T, Fischer CE Tags: Neurocase Source Type: research

What to make of equivocal amyloid imaging results.
Abstract Introduction: Six patients with equivocal amyloid-PET results are discussed.Methods: Patients underwent clinical/neuropsychological assessment, MRI, and amyloid-PET. Equivocal amyloid-PET was defined as cortical ligand binding with SUVR
Source: Neurocase - May 15, 2020 Category: Neurology Authors: Burrell JR, Foxe D, Leyton C, Piguet O, Hodges JR Tags: Neurocase Source Type: research

Radiographic and neurobehavioral profile of sports-related concussion associated with scholastic wrestling: a case report.
We present the case of a 15-year-old female scholastic wrestler who developed acute encephalopathy, macroscopic white matter injury on imaging, and chronic behavioral changes from inadequate neuro-recovery after a documented SRC. We also compare her case with established SRC data, demonstrating that wrestling-related concussions and repetitive head impacts can produce similar degrees of diffuse neuroinflammation, myelinated axonopathy, blood-brain barrier disruption, and post-concussive symptoms. PMID: 32412324 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - May 15, 2020 Category: Neurology Authors: Li W, Chang C, Liang S, Bigler ED Tags: Neurocase Source Type: research

When posterior cortical atrophy invests art: a case report.
;re C Abstract A 63-year-old woman was referred for visuospatial difficulties. The clinical and neuropsychological examination in association with imaging and biomarkers led to a diagnosis of posterior cortical atrophy (PCA). The patient, an amateur watercolor artist, continued to paint throughout her disease and her paintings illustrate in an original way the progression of her disorders. At an advanced stage, the evolution of neurovisual disorders is difficult to evaluate in patients. While studies have shown changes in artistic style in neurodegenerative diseases, none of them concerned PCA. Artistic production...
Source: Neurocase - May 7, 2020 Category: Neurology Authors: Rocher L, Evrard C, Evain S, Boutoleau-Bretonnière C Tags: Neurocase Source Type: research

Pure word deafness in a patient with bilateral ischemic stroke in the superior temporal gyrus (STG).
Conclusions: Our case suggested that bilateral, symmetric lesions in the region of STG could cause pure world deafness. The diversity and severity of symptoms confirm the necessity of pure world deafness classification for subtypes. PMID: 32364009 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - May 2, 2020 Category: Neurology Authors: Slotwinski K, Ejma M, Szczepanska A, Budrewicz S, Koszewicz M Tags: Neurocase Source Type: research

Proactive interference apraxic agraphia: a writing and drawing disorder associated with corticobasal syndrome.
Abstract Proactive interference is when a previously performed task impairs performance on a current task. It is often associated with memory tasks and has not been reported to interfere with writing or drawing. We evaluated a left-handed man diagnosed with corticobasal syndrome who had a two-year history of progressive agraphia. On the sentence writing and clock drawing tasks, he initially wrote letters and numbers correctly but revealed an increase of movement errors as the tasks progressed. We propose the term "proactive interference apraxic agraphia" for this novel disor...
Source: Neurocase - April 23, 2020 Category: Neurology Authors: Julayanont P, Burks DW, Heilman KM Tags: Neurocase Source Type: research

Atypical pantothenate kinase-associated neurodegeneration with PANK2 mutations : clinical description and a review of the literature.
Abstract Panthothenate kinase-associated neurodegeneration (PKAN) is arare neurodegeneration caused by mutations in the pantothenate kinase (PANK2) gene, which is located on chromosome 20p13. These mutations result in iron accumulation in the brain basal ganglia leading to parkinsonism, dysarthria, spasticity, cognitive impairment, and retinopathy. Herein, we report acase of adult-onset PKAN who presented with young-onset action tremor, bradykinesia, dysarthria, and bilateral interossei atrophy.  Neuroimaging demonstrated "eye-of-the-tiger signs". Through analyzing PANK2 gene,&nb...
Source: Neurocase - April 20, 2020 Category: Neurology Authors: Pan S, Zhu C Tags: Neurocase Source Type: research

Refractory epilepsy in PSEN 1 mutation (I83T).
We report the case of a 32 years old man with a family history of  early onset AD associated with a PSEN1 mutation in the exon 4 (I83T). The proband's, carrying the mutation,  present a refractory epilepsy predating cognitive decline. We discuss the physiopathological mechanisms of epilepsy during AD associated with PSEN 1 mutation, the possibility of linking this epilepsy to the mutation?. PMID: 32241222 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - April 3, 2020 Category: Neurology Authors: Fray S, Rassas A, Messaoud T, Belal S Tags: Neurocase Source Type: research

Anxiety as the only manifestation of focal non-convulsive status epilepticus: case report and review of the literature.
We describe a patient with focal epilepsy and recurrent hyperkinetic seizures who also presented prolonged episodes characterized by massive anxiety, alarm and fear. A Video-Electroencephalographic monitoring performed during one of these attacks revealed a continuous epileptiform activity over the right frontal regions, consistent with a focal non-convulsive status epilepticus accounting for the patient's psychiatric symptoms. Our case confirms the complex relationship between epilepsy and anxiety. A review of the literature is also included. PMID: 32228130 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - March 31, 2020 Category: Neurology Authors: Albini M, Morano A, Fattouch J, Fanella M, Avorio F, Basili LM, Cerulli Irelli E, Manfredi M, Giallonardo AT, Di Bonaventura C Tags: Neurocase Source Type: research

BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study.
Abstract Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates "brain-age" from brain imaging. YMR's brain-aging rate appeared slower than that of controls suggesting early maturation and delayed aging. At 41 years, his brain resembled that of a 33-year-old. Specific regional changes did not differentiate YMR from controls, suggestin...
Source: Neurocase - February 26, 2020 Category: Neurology Authors: Adluru N, Korponay CH, Norton DL, Goldman RI, Davidson RJ Tags: Neurocase Source Type: research

Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity.
We report the case of a patient with eye-movement abnormalities and gait instability, reminiscent of progressive supranuclear palsy-Richardson's syndrome (PSP-RS), who later developed upper motor neuron symptoms suggestive of primary lateral sclerosis (PLS). Neuropathological assessment revealed GGT type III pathology. A theoretical framework is proposed to help clinicians predict GGT in subjects with coexistent features of PSP-RS and PLS. PMID: 32090696 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - February 23, 2020 Category: Neurology Authors: Liu AJ, Chang JE, Naasan G, Boxer AL, Miller BL, Spina S Tags: Neurocase Source Type: research

The Neurology of Acquired Pedophilia.
Abstract The clinicoanatomic cases of acquired pedophilia that have been published in the medical and forensic literature up to 2019 are reviewed. Twenty-two cases fit our inclusion criteria. All but one were men, and in only one case the injury was localized to the left hemisphere. Hypersexuality was present in 18 cases. The damaged areas fell within the frontotemporoinsular cortices and related subcortical nuclei; however, the anterior hypothalamus was spared. Damage to parts of the right frontotemporoinsular lobes with sparing of the anterior hypothalamus seems to be critical for the emergence of acquired pedop...
Source: Neurocase - February 20, 2020 Category: Neurology Authors: Lopes PMG, Prado CSC, de Oliveira-Souza R Tags: Neurocase Source Type: research

Impaired perception of simultaneous stimuli in a patient with posterior cortical atrophy: an attentional account.
Abstract We assessed visuospatial abilities in PCA. Sequential display of two simple geometric figures enhanced detection and discrimination relative to simultaneous display (Exps 1 & 2). Comparing edges of a single object enhanced discrimination relative to comparing edges of two separate objects, consistent with object-based attention (Exp. 3). Recognition of complex line drawings was spared for a single object but disrupted by an attention-grabbing small circle (Exp. 4). A covert orienting task showed difficulty disengaging from previous locations and attentional bias...
Source: Neurocase - February 18, 2020 Category: Neurology Authors: Fernandez-Duque D, Black SE Tags: Neurocase Source Type: research

Bilateral basal ganglia infarcts presenting as rapid onset cognitive and behavioral disturbance.
We describe a rare case of a patient with rapid onset, prominent cognitive and behavioral changes who presented to our rapidly progressive dementia program with symptoms ultimately attributed to bilateral basal ganglia infarcts involving the caudate heads. We review the longitudinal clinical presentation and neuropsychological testing for this patient, and discuss the implicated basal ganglia and frontal lobe neuroanatomy. PMID: 32046584 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - February 11, 2020 Category: Neurology Authors: Hellmuth J, Casaletto K, Cuneo R, Possin KL, Dillon W, Geschwind MD Tags: Neurocase Source Type: research

Delayed neuropsychiatric syndrome of acute carbon monoxide poisoning from oak burning gas cured by therapy combined with transplantation of human umbilical cord blood stem cell, injection of nicholine, and intranasal inhalation of insulin.
Conclusion: This new therapy is promising for the treatment of delayed NSCs. PMID: 31868097 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - December 22, 2019 Category: Neurology Authors: Yom DY, Hwang SK, Jon SG, Ri R Tags: Neurocase Source Type: research

Diagnosing gaze and arrow cueing effects in unilateral spatial neglect.
Abstract Individuals with left unilateral spatial neglect (USN) following a right hemisphere lesion show difficulty in orienting their attention toward stimuli presented on the left. In normal cognition, others' gaze direction and a pointing arrow naturally guide visual attention. Here, we explore a method to identify patients who may benefit from these skills as a base for compensation during rehabilitation. We tested gaze and arrow cueing effects in 26 healthy participants and in 13 patients with USN. Our data show that brain injuries causing USN do not affect gaze and arrow cueing in a consistent manner from on...
Source: Neurocase - December 19, 2019 Category: Neurology Authors: Narison R, De Montalembert M, Conty L Tags: Neurocase Source Type: research

Very early-onset of RBD with ADHD: a case report study.
Abstract We experienced a case of very early-onset REM sleep behavior disorder (RBD) with ADHD. This case showed typical RBD symptoms with REM sleep without atonia on polysomnography. Methylphenidate, which enhances the dopamine system, attenuated his ADHD symptoms but not RBD symptoms. We speculate that the dysfunction of the laterodorsal tegmental nucleus in the pontine was responsible for the symptoms of RBD and ADHD in this case. Very early-onset RBD is rare, and its profile is not well known. ADHD with dysfunction in the laterodorsal tegmental nucleus may form asubtype of ADHD that is commonly comorbid w...
Source: Neurocase - November 28, 2019 Category: Neurology Authors: Takagi S, Yamashiro Y, Sugihara G, Takahashi H, Matsuura M Tags: Neurocase Source Type: research

Substantiating synesthesia: a novel aid in a case of grapheme-colour synesthesia and concomitant dyscalculia.
Abstract Here we present the case of SP, a 21-year-old female with life-long dyscalculia. SP was subsequently diagnosed with grapheme-color synesthesia, a diagnosis that serendipitously catalyzed our development of a novel aid:The digit-color calculator (DCC). The DCC substantiates SP's color concurrents, dramatically ameliorating her difficulties with basic calculations. We envisage the DCC and its analogues may assist others in educational settings, particularly if they experience difficulties with the acquisition of literacy and numeracy. Further devices that leverage synesthesia may also have the potential to ...
Source: Neurocase - November 27, 2019 Category: Neurology Authors: Berger JJ, Harris IM, Whittingham KM, Terpening Z, Watson JDG Tags: Neurocase Source Type: research

Specific cognitive theory of mind and behavioral dysfunctions in early manifest Huntington disease: a case report.
Abstract Huntington's disease (HD) is a devastating illness, associated with progressive motor, behavioral and cognitive dysfunctions. However, some studies emphasized that social cognition impairment could occur prior to the onset of these other symptoms. Here, we report the case of a 47 years old patient with early manifest HD, whose complaint was mainly related to the behavioral sphere. He exhibited a significant impairment of Theory of Mind abilities as well as behavioral, and discrete motor symptoms without noticeable cognitive decline. This case study suggests that social cognition impairments and behavioral...
Source: Neurocase - November 26, 2019 Category: Neurology Authors: Caillaud M, Laisney M, Bejanin A, Scherer-Gagou C, Bonneau D, Duclos H, Eustache F, Verny C, Desgranges B, Allain P Tags: Neurocase Source Type: research

Direct evidence of EEG coherence in alleviating phantom limb pain by virtual referred sensation: Case report.
Abstract Virtual reality (VR) systems have been integrated into rehabilitation techniques for phantom limb pain (PLP). In this case report, we used electroencephalography (EEG) to analyze corticocortical coherence between the bilateral sensorimotor cortices during vibrotactile stimulation in conjunction with VR rehabilitation in two PLP patients. As a result, we observed PLP alleviation and increased alpha wave coherence during VR rehabilitation when stimulation was delivered to the cheek and shoulder (referred sensation areas) of the affected side. Vibrotactile stimulation with VR rehabilitation may enhance the a...
Source: Neurocase - November 24, 2019 Category: Neurology Authors: Osumi M, Sano Y, Ichinose A, Wake N, Yozu A, Kumagaya SI, Kuniyoshi Y, Morioka S, Sumitani M Tags: Neurocase Source Type: research

Constructing calendars in the brain.
Abstract By studying an enigmatic condition called, "calendar synesthesia", we explored the elusive boundary between perception, visual imagery, and the manner in which we construct an internal mental calendar by mapping time-sequences onto spatial maps. We use a series of demonstrations to establish that these calendars act more like real objects activating sensory pathways rather than purely abstract symbolic descriptions that bear no resemblance to an actual calendar. We propose that the calendar is enshrined in acircuitry involving the hippocampal place-cells and entorhinal grid-cells, whic...
Source: Neurocase - November 24, 2019 Category: Neurology Authors: Ramachandran VS, Chunharas C, Marcus Z Tags: Neurocase Source Type: research

Recovery from tactile agnosia: a single case study.
Abstract In a patient suffering from tactile agnosia a comparison was made (using the ABABAB paradigm) between three blocks of neuropsychological rehabilitation sessions involving off-line anodal transcranial direct current stimulation (anodal-tDCS) and three blocks of rehabilitation sessions without tDCS. During the blocks with anodal-tDCS, the stimulation was administered in counterbalanced order to two sites: i) the perilesional parietal area (specific stimulation) and ii) an occipital area far from the lesion (nonspecific stimulation).Rehabilitation associated with anodal-tDCS (in particular in the perilesiona...
Source: Neurocase - November 22, 2019 Category: Neurology Authors: D'Imperio D, Avesani R, Rossato E, Aganetto S, Scandola M, Moro V Tags: Neurocase Source Type: research

A case of TDP-43 type C pathology presenting as nonfluent variant primary progressive aphasia.
We report a case of rapidly progressive nonfluent variant PPA (nfvPPA), age at onset 77 years old and disease duration 3.3 years, who came to post mortem and was found to have TDP-43 type C pathology, an unusual finding for nfvPPA. All prior TDP-43 type C cases from the UCL FTD cohort (n=25) had a semantic variant PPA (svPPA) phenotype, with all having a younger age at onset and longer disease duration than the nfvPPA case. Volumetric analysis of MRI from the nfvPPA case, twelve of the svPPA cases and ten age-matched controls was performed. Whilst left frontal and insular volumes were lower in the nfvPPA case compared with...
Source: Neurocase - November 21, 2019 Category: Neurology Authors: Adams-Carr KL, Bocchetta M, Neason M, Holton JL, Lashley T, Warren JD, Rohrer JD Tags: Neurocase Source Type: research

Electroconvulsive therapy in an adolescent with bipolar disorder, substance use, and body dysmorphic disorder comorbidity: case report.
v A Abstract Our case report is on the use of electroconvulsive treatment (ECT) in an adolescent with Bipolar Disorder (BPD), Substance Use Disorder (SUD) and comorbid Body Dysmorphic Disorder (BDD). In our case, ECT was not considered at the first stage, but we encountered medication noncompliance and treatment resistance. Symptoms of body dysmorphic disorder completely disappeared after ECT, which is consistent with the literature. ECT is a treatment with a low side effect profile in treatment-resistant cases. In addition, it will be useful to increase the knowledge and experience of clinicians on ECT and to pro...
Source: Neurocase - October 23, 2019 Category: Neurology Authors: Başgül ŞS, Luş MG, Hashimov A Tags: Neurocase Source Type: research

Category specific recall in acute stroke: a case with letter speech.
In this report, we describe a similar case with a transient episode of utterances of randomly selected letters. Like in the three previous cases, this episode was preceded by a brief stage of mutism and ultimately evolved to Wernicke's aphasia over a period of days. This phenomenon is reviewed with reference to linguistic models and neuroanatomic and neurophysiological correlates. PMID: 31571518 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - October 1, 2019 Category: Neurology Authors: De Letter M, Van Borsel J, Lanckmans E, Batens K, Hemelsoet D, Duyck W, Fias W, Santens P Tags: Neurocase Source Type: research

Growing up with Bilateral parieto-occipital injury: over ten years of clinical observation and neuropsychological follow-up.
Abstract This paper presents a follow-up of a child with Balint's syndrome over more than a decade. The patient experienced traumatic brain injury before age 12, resulting in bilateral occipito-parietal infarctions and a clinical presentation of Balint's syndrome. Neuropsychological assessments at three time points showed average verbal abilities alongside persistent difficulties in visual orientation, mirrored in the patient's daily life. Her outstanding compensatory abilities in the face of these impairments are discussed with respect to the recruitment of the ventral visual stream and the role of top-down proce...
Source: Neurocase - October 1, 2019 Category: Neurology Authors: Landa J, Bar O, Bord A, Patael SZ, Livny A, Sadeh Vered T, Tsarfaty G, Ahonniska-Assa J Tags: Neurocase Source Type: research

Neural activation for actual and imagined movement following unilateral hand transplantation: a case study.
We report functional magnetic resonance imaging (fMRI) findings for neural activation related to actual and imagined movement, for a 54-year-old male patient, who had received a donor hand transplant 50 years following amputation. Two assessments, conducted 3 months and 6 months post-operatively, demonstrate engagement of motor-control related brain regions for the transplanted hand, during both actual and imagined movement of the fingers. The intact hand exhibited a more intense and focused pattern of activation for actual movement relative to imagined movement, whereas activation for the transplanted hand was more widely...
Source: Neurocase - September 24, 2019 Category: Neurology Authors: Madden DJ, Melton MS, Jain S, Cook AD, Browndyke JN, Harshbarger TB, Cendales LC Tags: Neurocase Source Type: research

Transient naming deficits associated with insular lesions in a patient with encephalitis.
We describe a patient with acute herpes simplex encephalitis with left-hemispheric hippocampal, parahippocampal and insular lesions. Although prototypic language areas were unaffected, the patient suffered from an inability to name objects or animals displayed on pictures. This deficit was transient and gradually disappeared 8 weeks after the initial diagnosis. Our findings are in line with a previous report showing similar deficits in a patient with a comparable lesion pattern and support the hypothesis that left insular lesions can produce severe naming deficits. Using FDG-PET we ruled out that functional deactivati...
Source: Neurocase - September 18, 2019 Category: Neurology Authors: Marxreiter F, Utz K, Schlachetzki JCM, Seifert F, Schmidt M, Doerfler A, Schwab S, Schenk T Tags: Neurocase Source Type: research

Similar neurocognitive patterns in patients treated with lenalidomide: chemobrain effect?
Conclusions: Lenalidomide treatments can determine severe cognitive impairments especially in elderly patients. Our data suggest the need for a careful evaluation of cognitive decline risk before and after drug administration. However, larger studies are required to confirm our findings. PMID: 31522586 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - September 15, 2019 Category: Neurology Authors: Calvi E, Marchetti M, Santagata F, Luppi C, Coppo E, Massaia M, Isaia GC Tags: Neurocase Source Type: research

Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program.
Abstract In high-functioning autism, deficits in emotional processing and theory of mind are relevant to understanding the particularities of social functioning. Here we used a multiple baseline and ABA single-case design to assess the efficacy of an individualized social cognitive training program using both pen-and-paper and computerized materials for an 18-year old patient. After the treatment phase, we found significant improvement in both emotional processes and theory of mind. These results provide further significant data showing that therapeutic tools based on digital relational simulation are a promising ...
Source: Neurocase - September 15, 2019 Category: Neurology Authors: Peyroux E, Franck N Tags: Neurocase Source Type: research

A shrunken world - micropsia after a right occipito-parietal ischemic stroke.
We examined a patient who, after a right occipito-parietal stroke, subjectively reported perceiving everything at seventy percent of the actual size. Using experimental tasks, we confirmed the extent of his micropsia at 70%. Visual half-field tests showed an impaired perception of shape, location and motion in the left visual field. As his micropsia concerns the complete visual field, we suggest that it is caused by a higher-order compensation process in order to reconcile the conflicting information from the two hemifields. PMID: 31462163 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - August 28, 2019 Category: Neurology Authors: Van Den Berg NS, Huitema RB, Spikman JM, Van Laar PJ, De Haan EHF Tags: Neurocase Source Type: research

The importance of time limits in detecting signs of left visual peripersonal neglect: a multiple single-case, pilot study.
Abstract We developed a new visual search test to assess signs of left visual peripersonal neglect. Five right-hemisphere-damaged patients, 10 healthy controls, and 10 orthopedic controls were administered the test in four conditions: easy task (no distractors)/time-limited (45''), easy task (no distractors)/time-unlimited, difficult task (distractors)/time-limited (45''), difficult task (distractors)/time-unlimited. With respect to controls, most RHDP showed signs of left visual peripersonal neglect in the time-limited condition, but not in the time-unlimited condition, particularly on th...
Source: Neurocase - August 26, 2019 Category: Neurology Authors: Priftis K, Di Salvo S, Zara D Tags: Neurocase Source Type: research

Cognitive characterization of SCAR10 caused by a homozygous c.132dupA mutation in the ANO10 gene.
allo F, Montón F Abstract Autosomal recessive spinocerebellar ataxia type 10 (SCAR10) caused by a homozygous c.132dupA mutation in the anoctamin 10 gene is infrequent and little is known about its cognitive profile. Three siblings (1 male) with this mutation were assessed with a neuropsychological battery measuring multiple cognitive domains. The deficits observed in one patient were in executive functions whereas the other two patients showed deficits in practically all the functions. Cognitive impairment seems to be a characteristic of the SCAR10 produced by this mutation, with a range from mild impairmen...
Source: Neurocase - August 19, 2019 Category: Neurology Authors: Nieto A, Pérez-Flores J, Corral-Juan M, Matilla-Dueñas A, Martínez-Burgallo F, Montón F Tags: Neurocase Source Type: research

Aprosodia and prosoplegia with right frontal neurodegeneration.
We describe a patient with progressive aprosodia and prosoplegia who had right greater than left perisylvian and temporal atrophy with an anterior predominance. We discuss the importance of assessing affective prosody and facial expression to arrive at an accurate clinical diagnosis. PMID: 31335278 [PubMed - as supplied by publisher] (Source: Neurocase)
Source: Neurocase - July 23, 2019 Category: Neurology Authors: Bateman JR, Filley CM, Ross ED, Bettcher BM, Hubbard HI, Babiak M, Pressman PS Tags: Neurocase Source Type: research

Pure topographical disorientation in novel environments without anterograde amnesia: a case study.
Abstract Topographical disorientation (TD) in novel environments is considered to be a part of anterograde amnesia. A 56-year-old woman presented with pure TD only in novel environments following limbic encephalitis. She could not remember directions inside the hospital on weekly outpatient visits; however, her verbal and visual anterograde memories were normal. In the test of learning photographs of scenes, faces, and objects, only her scores for landscapes were worse than those in healthy controls. These findings suggested that her TD specific to landscapes and directions in novel environments was caused by cate...
Source: Neurocase - July 12, 2019 Category: Neurology Authors: Oishi Y, Yamakawa T, Nagasawa H, Suzuki K Tags: Neurocase Source Type: research