Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders
Neurocase. 2021 May 2:1-4. doi: 10.1080/13554794.2021.1921222. Online ahead of print.ABSTRACTBrain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that ...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Akiyuki Hiraga Masahiro Mori Satoshi Kuwabara Source Type: research

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.PMID:33934685 |...
Source: Neurocase - May 3, 2021 Category: Neurology Authors: Stefanie Danielle Pina-Escudero Maira Okada de Oliveira Alisson Snyder Bruce L Miller Source Type: research

Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes
We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. These two cases confirm the notion of s...
Source: Neurocase - April 27, 2021 Category: Neurology Authors: Fatma Ozlem Hokelekli Jennifer L Whitwell Mary M Machulda David T Jones Ryan J Uitti Nha Trang Thu Pham Caterina Giannini Matthew Baker Val J Lowe Dennis W Dickson Keith A Josephs Source Type: research

Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes
We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. These two cases confirm the notion of s...
Source: Neurocase - April 27, 2021 Category: Neurology Authors: Fatma Ozlem Hokelekli Jennifer L Whitwell Mary M Machulda David T Jones Ryan J Uitti Nha Trang Thu Pham Caterina Giannini Matthew Baker Val J Lowe Dennis W Dickson Keith A Josephs Source Type: research

Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes
We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. These two cases confirm the notion of s...
Source: Neurocase - April 27, 2021 Category: Neurology Authors: Fatma Ozlem Hokelekli Jennifer L Whitwell Mary M Machulda David T Jones Ryan J Uitti Nha Trang Thu Pham Caterina Giannini Matthew Baker Val J Lowe Dennis W Dickson Keith A Josephs Source Type: research

Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes
We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. These two cases confirm the notion of s...
Source: Neurocase - April 27, 2021 Category: Neurology Authors: Fatma Ozlem Hokelekli Jennifer L Whitwell Mary M Machulda David T Jones Ryan J Uitti Nha Trang Thu Pham Caterina Giannini Matthew Baker Val J Lowe Dennis W Dickson Keith A Josephs Source Type: research

Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes
We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. These two cases confirm the notion of s...
Source: Neurocase - April 27, 2021 Category: Neurology Authors: Fatma Ozlem Hokelekli Jennifer L Whitwell Mary M Machulda David T Jones Ryan J Uitti Nha Trang Thu Pham Caterina Giannini Matthew Baker Val J Lowe Dennis W Dickson Keith A Josephs Source Type: research

The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [ < sup > 18 < /sup > F]FDG-PET and pathological assessment
We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.PMID:33881963 | DOI:10.1080/13554794.2021.1905855 (Source: Neurocase)
Source: Neurocase - April 21, 2021 Category: Neurology Authors: Marie-Paule E van Engelen Annemieke J M Rozemuller H ülya Ulugut Erkoyun Colin Groot Jay L P Fieldhouse Ted Koene Rik Ossenkoppele Flora T Gossink Welmoed A Krudop Everard G B Vijverberg Annemieke Dols Frederik Barkhof Bart N M Van Berckel Philip Schelte Source Type: research

The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [ < sup > 18 < /sup > F]FDG-PET and pathological assessment
We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.PMID:33881963 | DOI:10.1080/13554794.2021.1905855 (Source: Neurocase)
Source: Neurocase - April 21, 2021 Category: Neurology Authors: Marie-Paule E van Engelen Annemieke J M Rozemuller H ülya Ulugut Erkoyun Colin Groot Jay L P Fieldhouse Ted Koene Rik Ossenkoppele Flora T Gossink Welmoed A Krudop Everard G B Vijverberg Annemieke Dols Frederik Barkhof Bart N M Van Berckel Philip Schelte Source Type: research

The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [ < sup > 18 < /sup > F]FDG-PET and pathological assessment
We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.PMID:33881963 | DOI:10.1080/13554794.2021.1905855 (Source: Neurocase)
Source: Neurocase - April 21, 2021 Category: Neurology Authors: Marie-Paule E van Engelen Annemieke J M Rozemuller H ülya Ulugut Erkoyun Colin Groot Jay L P Fieldhouse Ted Koene Rik Ossenkoppele Flora T Gossink Welmoed A Krudop Everard G B Vijverberg Annemieke Dols Frederik Barkhof Bart N M Van Berckel Philip Schelte Source Type: research

The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [ < sup > 18 < /sup > F]FDG-PET and pathological assessment
We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.PMID:33881963 | DOI:10.1080/13554794.2021.1905855 (Source: Neurocase)
Source: Neurocase - April 21, 2021 Category: Neurology Authors: Marie-Paule E van Engelen Annemieke J M Rozemuller H ülya Ulugut Erkoyun Colin Groot Jay L P Fieldhouse Ted Koene Rik Ossenkoppele Flora T Gossink Welmoed A Krudop Everard G B Vijverberg Annemieke Dols Frederik Barkhof Bart N M Van Berckel Philip Schelte Source Type: research

The man behind the bed: a case of peduncular hallucinosis treated with quetiapine and melatonin
Neurocase. 2021 Apr 18:1-4. doi: 10.1080/13554794.2021.1915338. Online ahead of print.ABSTRACTAn 81-year-old female presented with a right pontine infarct and later developed recurrent vivid hallucinations. After a workup for delirium and hallucinosis was unrevealing, a diagnosis of peduncular hallucinosis (PH) was proposed. Treatment with quetiapine and, later, adjunctive nightly melatonin resulted in return to cognitive baseline. An array of etiologies can be responsible for visual hallucinations, including PH. Herein, we review several disorders of hallucinosis and their diagnostic workup. Additionally, we explore the p...
Source: Neurocase - April 19, 2021 Category: Neurology Authors: Joseph LaPorta Robert Stanton Adam Koss Source Type: research

The man behind the bed: a case of peduncular hallucinosis treated with quetiapine and melatonin
Neurocase. 2021 Apr 18:1-4. doi: 10.1080/13554794.2021.1915338. Online ahead of print.ABSTRACTAn 81-year-old female presented with a right pontine infarct and later developed recurrent vivid hallucinations. After a workup for delirium and hallucinosis was unrevealing, a diagnosis of peduncular hallucinosis (PH) was proposed. Treatment with quetiapine and, later, adjunctive nightly melatonin resulted in return to cognitive baseline. An array of etiologies can be responsible for visual hallucinations, including PH. Herein, we review several disorders of hallucinosis and their diagnostic workup. Additionally, we explore the p...
Source: Neurocase - April 19, 2021 Category: Neurology Authors: Joseph LaPorta Robert Stanton Adam Koss Source Type: research

The man behind the bed: a case of peduncular hallucinosis treated with quetiapine and melatonin
Neurocase. 2021 Apr 18:1-4. doi: 10.1080/13554794.2021.1915338. Online ahead of print.ABSTRACTAn 81-year-old female presented with a right pontine infarct and later developed recurrent vivid hallucinations. After a workup for delirium and hallucinosis was unrevealing, a diagnosis of peduncular hallucinosis (PH) was proposed. Treatment with quetiapine and, later, adjunctive nightly melatonin resulted in return to cognitive baseline. An array of etiologies can be responsible for visual hallucinations, including PH. Herein, we review several disorders of hallucinosis and their diagnostic workup. Additionally, we explore the p...
Source: Neurocase - April 19, 2021 Category: Neurology Authors: Joseph LaPorta Robert Stanton Adam Koss Source Type: research

The man behind the bed: a case of peduncular hallucinosis treated with quetiapine and melatonin
Neurocase. 2021 Apr 18:1-4. doi: 10.1080/13554794.2021.1915338. Online ahead of print.ABSTRACTAn 81-year-old female presented with a right pontine infarct and later developed recurrent vivid hallucinations. After a workup for delirium and hallucinosis was unrevealing, a diagnosis of peduncular hallucinosis (PH) was proposed. Treatment with quetiapine and, later, adjunctive nightly melatonin resulted in return to cognitive baseline. An array of etiologies can be responsible for visual hallucinations, including PH. Herein, we review several disorders of hallucinosis and their diagnostic workup. Additionally, we explore the p...
Source: Neurocase - April 19, 2021 Category: Neurology Authors: Joseph LaPorta Robert Stanton Adam Koss Source Type: research

Self-awareness in Transient Global Amnesia: distinguishing the effects of transient memory disorder vs. pre-existing vulnerability factors
Neurocase. 2021 Apr 15:1-9. doi: 10.1080/13554794.2021.1912359. Online ahead of print.ABSTRACTNumerous evidences suggest the existence of relationships between the impairment of episodic memory, acute stress exposure and variations in self-awareness (SA). Here, we examined 27 patients presenting transient global amnesia (TGA), a clinical condition which combines episodic amnesia and high anxiety, thanks to state and trait questionnaires of SA. We observed variation of SA depending on the stage of TGA (acute, recovery and follow-up). We also found preexisting differences in patient's awareness of their own image when the pr...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: C éline Becquet Fausto Viader Francis Eustache Peggy Quinette Source Type: research

Evolution of Capgras syndrome in neurodegenerative disease: the multiplication phenomenon
Neurocase. 2021 Apr 15:1-5. doi: 10.1080/13554794.2021.1905850. Online ahead of print.ABSTRACTCapgras syndrome (CS) is a delusional misidentification syndrome that is encountered in various pathologies. Here, we report the case of an 83-year-old woman affected by dementia with Lewy bodies who presented a CS during the disease. The neuropsychological assessment showed executive and face processing deficits. In this case, CS was characterized, in the beginning, by the duplication of a relative and then by its multiplication. To our knowledge, the description of the evolution of a CS in the course of a neurodegenerative disea...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Aline von Siebenthal Virginie Descloux Christel Borgognon Tatiana Massardi Serge Zumbach Source Type: research

A case of developmental pedophilia unmasked by frontotemporal dementia
Neurocase. 2021 Apr 15:1-10. doi: 10.1080/13554794.2021.1886310. Online ahead of print.ABSTRACTA 65-year-old right-handed man gradually became socially indifferent and less active. Four years later, he was indicted for molesting children on multiple occasions. Psychomotor slowness and executive impairment contrasted with sparing of language, semantic memory, visuospatial perception, construction praxis, and right-left orientation. Neuroimaging showed asymmetric atrophy of dorsomedial frontal and anterior temporal lobes, and hypoperfusion of medial prefrontal cortex consistent with a diagnosis of behavioral variant of front...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Catarina Sodr é de Castro Prado Pedro Maranh ão Gomes Lopes Jorge Moll Antonio DeSalles Ricardo de Oliveira-Souza Source Type: research

Self-awareness in Transient Global Amnesia: distinguishing the effects of transient memory disorder vs. pre-existing vulnerability factors
Neurocase. 2021 Apr 15:1-9. doi: 10.1080/13554794.2021.1912359. Online ahead of print.ABSTRACTNumerous evidences suggest the existence of relationships between the impairment of episodic memory, acute stress exposure and variations in self-awareness (SA). Here, we examined 27 patients presenting transient global amnesia (TGA), a clinical condition which combines episodic amnesia and high anxiety, thanks to state and trait questionnaires of SA. We observed variation of SA depending on the stage of TGA (acute, recovery and follow-up). We also found preexisting differences in patient's awareness of their own image when the pr...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: C éline Becquet Fausto Viader Francis Eustache Peggy Quinette Source Type: research

Evolution of Capgras syndrome in neurodegenerative disease: the multiplication phenomenon
Neurocase. 2021 Apr 15:1-5. doi: 10.1080/13554794.2021.1905850. Online ahead of print.ABSTRACTCapgras syndrome (CS) is a delusional misidentification syndrome that is encountered in various pathologies. Here, we report the case of an 83-year-old woman affected by dementia with Lewy bodies who presented a CS during the disease. The neuropsychological assessment showed executive and face processing deficits. In this case, CS was characterized, in the beginning, by the duplication of a relative and then by its multiplication. To our knowledge, the description of the evolution of a CS in the course of a neurodegenerative disea...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Aline von Siebenthal Virginie Descloux Christel Borgognon Tatiana Massardi Serge Zumbach Source Type: research

A case of developmental pedophilia unmasked by frontotemporal dementia
Neurocase. 2021 Apr 15:1-10. doi: 10.1080/13554794.2021.1886310. Online ahead of print.ABSTRACTA 65-year-old right-handed man gradually became socially indifferent and less active. Four years later, he was indicted for molesting children on multiple occasions. Psychomotor slowness and executive impairment contrasted with sparing of language, semantic memory, visuospatial perception, construction praxis, and right-left orientation. Neuroimaging showed asymmetric atrophy of dorsomedial frontal and anterior temporal lobes, and hypoperfusion of medial prefrontal cortex consistent with a diagnosis of behavioral variant of front...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Catarina Sodr é de Castro Prado Pedro Maranh ão Gomes Lopes Jorge Moll Antonio DeSalles Ricardo de Oliveira-Souza Source Type: research

Self-awareness in Transient Global Amnesia: distinguishing the effects of transient memory disorder vs. pre-existing vulnerability factors
Neurocase. 2021 Apr 15:1-9. doi: 10.1080/13554794.2021.1912359. Online ahead of print.ABSTRACTNumerous evidences suggest the existence of relationships between the impairment of episodic memory, acute stress exposure and variations in self-awareness (SA). Here, we examined 27 patients presenting transient global amnesia (TGA), a clinical condition which combines episodic amnesia and high anxiety, thanks to state and trait questionnaires of SA. We observed variation of SA depending on the stage of TGA (acute, recovery and follow-up). We also found preexisting differences in patient's awareness of their own image when the pr...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: C éline Becquet Fausto Viader Francis Eustache Peggy Quinette Source Type: research

Evolution of Capgras syndrome in neurodegenerative disease: the multiplication phenomenon
Neurocase. 2021 Apr 15:1-5. doi: 10.1080/13554794.2021.1905850. Online ahead of print.ABSTRACTCapgras syndrome (CS) is a delusional misidentification syndrome that is encountered in various pathologies. Here, we report the case of an 83-year-old woman affected by dementia with Lewy bodies who presented a CS during the disease. The neuropsychological assessment showed executive and face processing deficits. In this case, CS was characterized, in the beginning, by the duplication of a relative and then by its multiplication. To our knowledge, the description of the evolution of a CS in the course of a neurodegenerative disea...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Aline von Siebenthal Virginie Descloux Christel Borgognon Tatiana Massardi Serge Zumbach Source Type: research

A case of developmental pedophilia unmasked by frontotemporal dementia
Neurocase. 2021 Apr 15:1-10. doi: 10.1080/13554794.2021.1886310. Online ahead of print.ABSTRACTA 65-year-old right-handed man gradually became socially indifferent and less active. Four years later, he was indicted for molesting children on multiple occasions. Psychomotor slowness and executive impairment contrasted with sparing of language, semantic memory, visuospatial perception, construction praxis, and right-left orientation. Neuroimaging showed asymmetric atrophy of dorsomedial frontal and anterior temporal lobes, and hypoperfusion of medial prefrontal cortex consistent with a diagnosis of behavioral variant of front...
Source: Neurocase - April 15, 2021 Category: Neurology Authors: Catarina Sodr é de Castro Prado Pedro Maranh ão Gomes Lopes Jorge Moll Antonio DeSalles Ricardo de Oliveira-Souza Source Type: research

A case of juvenile CLN1- challenge in diagnosis and epilepsy treatment
DiscussionEpilepsy in all NCL patients is a major clinical issue and presumed related to neuronal excitation and epileptogenesis. The treatment of status epilepticus, in juvenile CLN1 patients, presents a particular challenge and requires monitoring of potential serious pharmacologic side effects of therapy.PMID:33849402 | DOI:10.1080/13554794.2021.1905852 (Source: Neurocase)
Source: Neurocase - April 14, 2021 Category: Neurology Authors: Ruzica Kravljanac Katherine Sims Source Type: research

Visual texture agnosia caused by bilateral posterior cerebral artery stroke: a case study
Neurocase. 2021 Apr 14:1-6. doi: 10.1080/13554794.2021.1909068. Online ahead of print.ABSTRACTA 57-year-old man presented with a bilateral posterior cerebral artery attack and was visually impaired. He had a hard time identifying familiar faces and shades. He also felt that the familiar building looked different, and complained that it was not possible to tell from visual information alone whether the food was cooked or the kimono fabric was soft.We assessed the patient's visual function using real materials and material images and was diagnosed with visual texture agnosia. There are few reports of visual texture agnosia, ...
Source: Neurocase - April 14, 2021 Category: Neurology Authors: Mamiko Sato Yasutaka Kobayashi Masahito Hitosugi Source Type: research

A case of juvenile CLN1- challenge in diagnosis and epilepsy treatment
DiscussionEpilepsy in all NCL patients is a major clinical issue and presumed related to neuronal excitation and epileptogenesis. The treatment of status epilepticus, in juvenile CLN1 patients, presents a particular challenge and requires monitoring of potential serious pharmacologic side effects of therapy.PMID:33849402 | DOI:10.1080/13554794.2021.1905852 (Source: Neurocase)
Source: Neurocase - April 14, 2021 Category: Neurology Authors: Ruzica Kravljanac Katherine Sims Source Type: research

Visual texture agnosia caused by bilateral posterior cerebral artery stroke: a case study
Neurocase. 2021 Apr 14:1-6. doi: 10.1080/13554794.2021.1909068. Online ahead of print.ABSTRACTA 57-year-old man presented with a bilateral posterior cerebral artery attack and was visually impaired. He had a hard time identifying familiar faces and shades. He also felt that the familiar building looked different, and complained that it was not possible to tell from visual information alone whether the food was cooked or the kimono fabric was soft.We assessed the patient's visual function using real materials and material images and was diagnosed with visual texture agnosia. There are few reports of visual texture agnosia, ...
Source: Neurocase - April 14, 2021 Category: Neurology Authors: Mamiko Sato Yasutaka Kobayashi Masahito Hitosugi Source Type: research

Sour aversion in frontotemporal dementia: a case report and review on physiologic-anatomic mechanisms
Neurocase. 2021 Mar 31:1-3. doi: 10.1080/13554794.2021.1905854. Online ahead of print.ABSTRACTFrontotemporal dementia (FTD) is a common cause of early-onset dementia characterized by behavioral and personality changes, as well as, altered eating habits. FTD is associated with complex changes in neural networks of gustatory processing which may be responsible for eating abnormalities. Here, we present a 66-years-old lady suffered from behavioral variant of FTD with an interesting symptom of food aversion, typically sour foods.PMID:33789074 | DOI:10.1080/13554794.2021.1905854 (Source: Neurocase)
Source: Neurocase - March 31, 2021 Category: Neurology Authors: Mostafa Almasi-Dooghaee Taravat Vahedi Nooshin Vahedi Babak Zamani Source Type: research

Sour aversion in frontotemporal dementia: a case report and review on physiologic-anatomic mechanisms
Neurocase. 2021 Mar 31:1-3. doi: 10.1080/13554794.2021.1905854. Online ahead of print.ABSTRACTFrontotemporal dementia (FTD) is a common cause of early-onset dementia characterized by behavioral and personality changes, as well as, altered eating habits. FTD is associated with complex changes in neural networks of gustatory processing which may be responsible for eating abnormalities. Here, we present a 66-years-old lady suffered from behavioral variant of FTD with an interesting symptom of food aversion, typically sour foods.PMID:33789074 | DOI:10.1080/13554794.2021.1905854 (Source: Neurocase)
Source: Neurocase - March 31, 2021 Category: Neurology Authors: Mostafa Almasi-Dooghaee Taravat Vahedi Nooshin Vahedi Babak Zamani Source Type: research