Editorial board
(Source: Maturitas)
Source: Maturitas - June 2, 2020 Category: Primary Care Source Type: research

A clinical guide to the pathophysiology, diagnosis and treatment of osteosarcopenia
The importance of preserving musculoskeletal health into old age is marked by the adverse outcomes sarcopenia (loss of muscle mass and function) and osteoporosis (bone loss) may confer such as an increased risk of falls, fractures, frailty, disability and premature death [1]. The role of these metabolically active tissues also extends beyond maintaining mobility and independence. For instance, skeletal muscle insulin resistance has been identified as the largest defect in type II diabetes [2], and the loss of muscle mass and strength correlates with cardiovascular disease in older adults [3]. (Source: Maturitas)
Source: Maturitas - June 1, 2020 Category: Primary Care Authors: Ben Kirk, Sarah Miller, Jesse Zanker, Gustavo Duque Source Type: research

Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health
The loss of bone quality and/or density is a para-physiological phenomenon observed in perimenopause and postmenopause, as well as in other conditions involving ageing, inflammatory and/or autoimmune diseases, chronic drug consumption (e.g. glucocorticoids, chemotherapies, etc) and/or nutritional deficiencies [1]. Data extensively agree with the key role of calcium (Ca) and vitamin D (vitD) supplementation for the prevention of osteopenia/osteoporosis in subjects at a higher risk of fragility fractures and for the treatment of bone strength reduction in association with antiresorptive [bisphosphonates (BPs), denosumab (Dma...
Source: Maturitas - May 29, 2020 Category: Primary Care Authors: Anna Capozzi, Giovanni Scambia, Stefano Lello Source Type: research

Attitude, confidence and social norm of Dutch occupational physicians regarding menopause in a work context
There is growing evidence that the experience of menopausal symptoms has negative impact on women's self-perceived work ability, productivity, capacity to work and work experience [1 –6]. Over 75% percent of women visiting a menopause outpatient clinic for severe symptoms associated with menopause report a low ability to perform their work regarding the physical and mental work demands [2]. The menopausal transition begins on average four years before the final menstrual perio d. Natural menopause in the developed world occurs around 50 to 51 years of age. (Source: Maturitas)
Source: Maturitas - May 27, 2020 Category: Primary Care Authors: Marije Geukes, Henk Oosterhof, Mari ëlle P. van Aalst, Johannes R. Anema Source Type: research

Eye health in older people at the time of corona
A day before the start of 2020, Dr Li Wenliang, a 33-year-old ophthalmologist working at the Wuhan Central Hospital sent a series of mobile texts that predicted a global tragedy in the offing, changing the course of his life in the process [1]. In these texts, sent to his medical school friends through the popular Chinese messaging service WeChat, Dr. Wenliang raised the alarm for 7 confirmed cases of an illness that resembled acute respiratory syndrome (SARS), with no clear subtype, in his hospital. (Source: Maturitas)
Source: Maturitas - May 27, 2020 Category: Primary Care Authors: Oscar H. Franco, Juan G. Gaviria, Jose M. Varas, Rajiv Chowdhury Source Type: research

Emotions, Relationships, Health and Illness into Old Age
Relationships can be defined broadly as the actual or perceived elements of our social world [1]. One important operationalization focuses on the broader social context (e.g., social networks, types of relationships) in which social interactions are embedded (Smith& Christakis, 2008). A second approach focuses on the affective qualities of relationships in terms of their positivity (e.g., support), negativity (e.g., undermining), or ambivalence (i.e., both positive and negative, [3]). Emotions, on the other hand, can be defined as having cognitive, behavioral, subjective, and physiological components. (Source: Maturitas)
Source: Maturitas - May 27, 2020 Category: Primary Care Authors: Bert N. Uchino, Karen S. Rook Source Type: research

Polycystic Ovary Syndrome and Aging: Health Implications After Menopause
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Depending on the diagnostic criteria used and the population studied, its prevalence ranges between 4-21% [1,2]. According to the widely accepted 2003 Rotterdam criteria, PCOS diagnosis requires at least two of the following three features: oligo-anovulation (OA), clinical/biochemical hyperandrogenism (HA) and presence of polycystic ovarian morphology (PCOM) on ultrasonography [3]. Based on the presence and/ or absence of these diagnostic features, different phenotypes have been identified (Table 1). (Source: Maturitas)
Source: Maturitas - May 26, 2020 Category: Primary Care Authors: Nafiye Helvaci, Bulent Okan Yildiz Source Type: research

Access to Learning Opportunities for Residents in Care Homes: Reviewing the challenges and possibilities
Learning is a human right as set out in Article 26 (1) and (2) of the United Nations (UN) Declaration of Human Rights (1948) [1]. This citizen ’s right has been well documented, for example, in 1991, the UN stated that older people should have access to appropriate educational programmes [2] and nearly thirty years later, in 2019, the Scottish Government pledged to make education accessible to all ages [3]. Despite the wealth of compelli ng policy documents, some cited in this paper below, on the benefits of learning in later life and of the positive contribution that engagement in learning can make to healthy ageing...
Source: Maturitas - May 26, 2020 Category: Primary Care Authors: Angela Kydd, Heather Fulford Source Type: research

The World Health Organization (WHO) approach to healthy ageing
The old age of an individual has always been interesting and attractive and started in ancient times. Marcus Tullius Cicero wrote an essay entitled “De Senectute” (The Old Age) in 44BC [1]. Cicero described ideas how individuals might preserve their health and vitality. That work can be understood as a presentation of the concept of “healthy ageing” but mainly focused on the individual. (Source: Maturitas)
Source: Maturitas - May 26, 2020 Category: Primary Care Authors: Ewa Rudnicka, Paulina Napiera ła, Agnieszka Podfigurna, Błażej Męczekalski, Roman Smolarczyk, Monika Grymowicz Source Type: research

Global frailty: the role of ethnicity, migration and socioeconomic factors
Health care systems internationally are facing the challenges associated with ageing populations. Global projections estimate that by 2050, one in six people will be over the age of 65, numbering around 1.5 billion people [1]. In 2018, over 65 year-olds outnumbered children under the age of five globally for the first time [1]. The United Nations (UN) predicts that in Europe by 2020 the number of people over the age of 85 ( “the oldest old”) will be 40 million, a considerable increase from 14 million in 2012 [2]. (Source: Maturitas)
Source: Maturitas - May 24, 2020 Category: Primary Care Authors: Zeinab Majid, Carly Welch, Justine Davies, Thomas Jackson Source Type: research

Effects of comorbid physical frailty and low muscle mass on incident disability in community-dwelling older adults: A 24-month follow-up longitudinal study
Recent evidence has indicated that Japan has one of the fastest-aging populations in the world, and it is estimated that by 2040, 35% of the population will be over 65 years of age [1]. With this rapid population aging, it is crucial to treat age-related health problem such as disability, which are conditions that need help with activities of daily living (e.g. bathing, dressing and walking) [2]. From the perspectives of health promotion and health economics among older adults, functional independence (i.e., absence of disability) should be maintained for as long as possible. (Source: Maturitas)
Source: Maturitas - May 21, 2020 Category: Primary Care Authors: Hideaki Ishii, Kota Tsutsumimoto, Takehiko Doi, Sho Nakakubo, Minji Kim, Satoshi Kurita, Hiroyuki Shimada Source Type: research

Five-year clinical and imaging outcomes of primary transobturator midurethral sling procedures for uncomplicated urodynamic stress incontinence
The prevalence of pelvic floor disorders such as stress urinary incontinence (SUI) increases with older age [1]. Surgeries are often necessary when SUI significantly affects women's quality of life and conservative treatment cannot solve the problem. The midurethral sling procedure has been regarded as the surgical option of choice of urodynamic stress incontinence (USI) [2,3]. Among the three main surgical approaches, the transobturator sling (TOT) procedure has a high usage worldwide, probably related to the avoidance of the retropubic space with its significant risk of visceral injury and bleeding risks [2,4]. (Source: Maturitas)
Source: Maturitas - May 18, 2020 Category: Primary Care Authors: Wen-Chen Huang, Jenn-Ming Yang, Hsin-Fu Chen Source Type: research

Neighborhood environments and intrinsic capacity interact to affect the health-related quality of life of older people in New Zealand
The World Health Organisation (WHO) ‘Framework for Policy for Healthy Aging’ [1] has shifted our perspectives on wellbeing for older people. It included recognition of the importance of environments for everyday functioning, providing the impetus for research on the interactions of intrinsic capacity (“the composite of all the p hysical and mental capacities of an individual” p.28) and environments of aging in predicting quality of life (QoL). (Source: Maturitas)
Source: Maturitas - May 17, 2020 Category: Primary Care Authors: Christine Stephens, Joanne Allen, Norah Keating, Ágnes Szabó, Fiona Alpass Source Type: research

Efficacy and safety of a low-dose continuous combined hormone replacement therapy with 0.5mg 17 β-estradiol and 2.5mg dydrogesterone in subgroups of postmenopausal women with vasomotor symptoms
Hormone replacement therapy (HRT) is the most effective treatment for vasomotor symptoms associated with menopause and may improve quality of life [1]. HRT is also effective for the prevention of postmenopausal osteoporosis [2]. Multiple HRT combinations are available. The individual drugs and their combination are important in determining their safety and efficacy. It is recognised that different progestogens [3], and estrogens have distinct properties. Guidelines recommend individualising and tailoring HRT according to symptoms and the need for prevention, as well as age, personal and family history, and the woman &rsquo...
Source: Maturitas - May 15, 2020 Category: Primary Care Authors: Sophia Tsiligiannis, Bettina C. Wick-Urban, Jan van der Stam, John C. Stevenson Source Type: research

Relationship between motoric cognitive risk syndrome, cardiovascular risk factors and disease, and incident cognitive impairment: Results from the “NuAge” study
Both subjective cognitive complaint (SCC) and slow gait speed have been independently associated with incident cognitive impairment [1,2]. This association is stronger when SCC is combined with slow gait speed compared to SCC or slow gait speed alone and characterizes motoric cognitive risk syndrome (MCR) in individuals free of dementia and gait disability [3]. A recent meta-analysis showed that the risk for incident cognitive impairment is doubled in individuals with MCR compared to those without MCR [3]. (Source: Maturitas)
Source: Maturitas - May 15, 2020 Category: Primary Care Authors: Olivier Beauchet, Harmehr Sekhon, Cyrille P Launay, Pierrette Gaudrea, Jos é A. Morais, Gilles Allali Source Type: research

The Belgian Bone Club 2020 guidelines for the management of osteoporosis in postmenopausal women
Osteoporotic fractures are a major cause of functional impairment, disability, pain, and mortality. However, the incidence and intensity of these adverse outcomes might be reduced if targeted state-of-the-art management of osteoporosis is applied. Comprehensive guidelines in osteoporosis should include recommendations about screening, diagnosis, treatment, and monitoring to allow their implementation in clinical practice [1]. Moreover, there is a need for country-specific guidelines because of differences in the epidemiology of the disease, health-care costs, and healthcare systems among countries. (Source: Maturitas)
Source: Maturitas - May 15, 2020 Category: Primary Care Authors: D. Sanchez-Rodriguez, P. Bergmann, J.J. Body, E. Cavalier, E. Gielen, S. Goemaere, B. Lapauw, MR Laurent, S. Rozenberg, G. Honvo, C. Beaudart, O. Bruy ère Source Type: research

Are we equal in adversity? Does Covid-19 affect women and men differently?
Unfortunately, it is well known that we are not all equal in adversity. It has been reported that older people and those with preexistent co-morbidities are at higher risk of dying from Covid-19 in the pandemic [1,3]. It is also possible that ethnic origin influences the prognosis of the Covid-19 infection, since diseases like diabetes and hypertension are more frequently found among patients of African origin [4]. Currently, it is unclear whether there is a direct link between race or ethnicity and the outcome of COVID-19 infection or whether race is a confounding factor due to the hidden effects of diabetes or hypertensi...
Source: Maturitas - May 14, 2020 Category: Primary Care Authors: Rozenberg Serge, Jean Vandromme, Martin Charlotte Source Type: research

How to manage osteoporosis before the age of 50
Osteoporosis is defined by the World Health Organization (WHO) as a ‘progressive systemic skeletal disease characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture’ [1]. Fractures in premenopausal women are less frequent than in postmenopausal women, but they m ay be an important indicator of underlying poor bone quality and future fracture risk [2]. According to the WHO, in postmenopausal women, osteoporosis is diagnosed when hip or spine bone mineral density (BMD) is two and a half standard deviations or mor...
Source: Maturitas - May 13, 2020 Category: Primary Care Authors: S. Rozenberg, O. Bruy ère, P. Bergmann, E. Cavalier, E. Gielen, S. Goemaere, J.M. Kaufman, B. Lapauw, M.R. Laurent, J. De Schepper, J.J. Body Source Type: research

Chinese Herbal Formula Siwutang for Treating Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Primary dysmenorrhea (PD) is a common gynecological disorder that usually begins in adolescence. It is defined as pain occurring with menses in the absence of pelvic pathology [1]. The prevalence varies between 45% and 95% of menstruating women [2]. The incidence rate of patients who have experienced moderate to severe pain ranges from 3% to 40% [3 –5]. Furthermore, PD results in 1/3 to 1/2 of patients missing school or work at least once per cycle. It has also become a public health problem that adversely affects daily activities and quality of life [6]. (Source: Maturitas)
Source: Maturitas - May 12, 2020 Category: Primary Care Authors: Geng Li, Aolin Liu, Mingjun Lin, Shaojun Liao, Zehuai Wen Tags: Review article Source Type: research

Multiple myeloma: Current and future management in the aging population
Multiple myeloma (MM) is a plasma cell dyscrasia that accounts for 15% approximately of all hematological malignancies. The median age at diagnosis is 70 years, and about 34-40% of patients with MM are older than 75 years [1,2]. Outcomes and overall survival have improved considerably as novel therapeutics continue to evolve with immunotherapy, targeted combination treatments, and routine incorporation of autologous stem cell transplantation (ASCT) in clinical practice [3]. In the modern era, MM patients younger than age 65 have a 10  year improved survival rate (9.6% vs. (Source: Maturitas)
Source: Maturitas - May 11, 2020 Category: Primary Care Authors: Despina Fotiou, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Meletios Athanasios Dimopoulos Source Type: research

An opportunity for patient-centered care: results from a secondary analysis of sex- and gender-based data in mobile health trials for chronic medical conditions
Traditional medical practice has suffered from a male bias that can lead to sub-optimal treatment options and a higher incidence of, potentially deadly, side-effects in the female patient population [1,2]. The reporting of sex and gender-related data is increasing in the medical literature over time, but substantial variations still exist between disciplines. [3]. Nevertheless, sex and gender are increasingly recognized as health modulators in the (bio)medical field. The impact of sex and gender on the development, diagnosis, treatment and long-term effects of diseases is now well documented [4,5]. (Source: Maturitas)
Source: Maturitas - May 11, 2020 Category: Primary Care Authors: Jiani Wang, J ürgen Barth, Irene Göttgens, Karma Emchi, Daniel Pach, Sabine Oertelt-Prigione Source Type: research

Potential effectiveness of Ospemifene on Detrusor Overactivity in patients with vaginal atrophy
The influence of estrogens on lower urinary tract function and how their insufficiency is associated with the genitourinary syndrome of menopause (GSM) is well known. A recent meta-analysis confirmed that women who were treated with vaginal estrogen at the recommended doses had an improvement in both genital and urinary symptoms 1. Ospemifene, a selective estrogen receptor modulator recently approved by the FDA for the treatment of postmenopausal women experiencing moderate-to-severe dyspareunia is an alternative to local estrogen therapy2. (Source: Maturitas)
Source: Maturitas - May 10, 2020 Category: Primary Care Authors: Lorenzo Novara, Luca Giuseppe Sgro, Matteo Mancarella, Roberto Capece, Elena Canale, Nicoletta Biglia Source Type: research

Editorial board
(Source: Maturitas)
Source: Maturitas - May 7, 2020 Category: Primary Care Source Type: research

Managing thromboembolic risk with menopausal hormone therapy and hormonal contraception in the COVID-19 pandemic: Recommendations from the Spanish Menopause Society, Sociedad Espa ñola de Ginecología y Obstetricia and Sociedad Española de Trombosis y Hemostasia
COVID-19 is an illness caused by infection with a new coronavirus (SARS-CoV-2) that is associated with a systemic inflammatory response, with activation of coagulation in patients who develop clinical disease. The coronavirus infection favors the appearance of thrombotic events of varying severity in different territories and has the capacity to produce coagulopathies and even disseminated intravascular coagulation (DIC) [1,2]. The possibility of coagulopathies makes it advisable to consider antithrombotic strategies such as the use of low molecular weight heparins (LMWHs) at specific prophylactic or treatment doses depend...
Source: Maturitas - May 5, 2020 Category: Primary Care Authors: Isabel Ram írez, Esther De la Viuda, Laura Baquedano, Pluvio Coronado, Plácido Llaneza, Nicolás Mendoza, Borja Otero, Sonia Sánchez, Mª Jesús Cancelo, José Antonio Páramo, Antonio Cano Source Type: research

Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality: A prospective study from UK Biobank
Low grip (muscle) strength, low muscle mass and slow walking pace (gait speed) have been shown to be strong independent predictors of morbidity and mortality in middle-aged and old-aged populations [1 –3]. These markers of physical capability are all known to decline after the age of ∼35 years, and with the rapid growth of ageing populations, the number of individuals with low levels of physical capability is also expected to be increased rapidly. This, in turn, will increase the number of pe ople who are at higher risk of developing non-communicable diseases [4]. (Source: Maturitas)
Source: Maturitas - May 4, 2020 Category: Primary Care Authors: Fanny Petermann-Rocha, K Ho Frederick, Paul Welsh, Daniel Mackay, Rosemary Brown, Jason M.R. Gill, Naveed Sattar, Stuart R Gray, Jill P Pell, Carlos A Celis-Morales Source Type: research

Multimorbidity in a cohort of middle-aged women: Risk factors and disease clustering
A large proportion of the global population, especially those aged 65 and above, is affected by multimorbidity. 1 This has been defined as the co-existence of at least two chronic diseases in the same individual. 2 However, there are broader definitions, such as the one proposed by the European General Practice Research Network, which defines multimorbidity as the combination of a chronic disease with at least one other chronic or acute illness, or a socio-economic or biological risk factor.3 Regardless of the definition, multimorbidity implies increased hospitalizations or mortality rates, fragility, depression, polypharm...
Source: Maturitas - May 4, 2020 Category: Primary Care Authors: Juan E. Bl ümel, Rodrigo M. Carrillo-Larco, María S. Vallejo, Peter Chedraui Source Type: research

Physical capability markers used to define sarcopenia and their association with cardiovascular, respiratory and cancer outcomes: A prospective study from UK Biobank
Low grip (muscle) strength, low muscle mass and slow walking pace (gait speed) have been shown to be strong independent predictors of morbidity and mortality in middle-aged and old-aged populations [1 –3]. These markers of physical capability are all known to decline after the age of ∼35 years, and with the rapid growth of ageing populations, the number of individuals with low levels of physical capability is also expected to be increased rapidly. This, in turn, will increase the number of people who are at higher risk of developing non-communicable diseases [4]. (Source: Maturitas)
Source: Maturitas - May 4, 2020 Category: Primary Care Authors: Petermann-Rocha Fanny, K Ho Frederick, Welsh Paul, Mackay Daniel, Brown Rosemary, Jason M.R. Gill, Sattar Naveed, Stuart R Gray, Jill P Pell, Carlos A Celis-Morales Source Type: research

Adult-onset autoimmune diabetes in 2020: an update
Autoimmune diabetes is a polygenic multifactorial disorder characterized by the destruction of pancreatic beta cells, on an autoimmune basis, resulting in absolute insulin deficiency [1]. Type 1 diabetes (T1D) is the most aggressive form of autoimmune diabetes and, historically, has been largely considered a disorder of children and adolescents [2]. However, it has been recognized that an increasing number of new autoimmune diabetes cases occur during adulthood. While a small percentage of these cases have a clinical presentation similar to T1D, there is a substantial number of people with an initial clinical diagnosis of ...
Source: Maturitas - April 30, 2020 Category: Primary Care Authors: Ernesto Maddaloni, Chiara Moretti, Carmen Mignogna, Raffaella Buzzetti Source Type: research

A randomized trial on the effect of oral combined estradiol and drospirenone on glucose and insulin metabolism in healthy menopausal women with a normal OGTT
Menopause is often associated with a central accumulation of body fat [1]. This may provoke insulin resistance, leading to hyperinsulinemia [2]. An increased insulin level is a risk factor for diabetes [3,4] and cardiovascular disease [5]. Moreover, the Women ’s Health Initiative (WHI) trial revealed that hyperinsulinemia is an independent risk factor for postmenopausal breast cancer [6]. As obese postmenopausal women have higher levels of estrogen, it is believed that estrogens are linked to increased breast cancer risk. (Source: Maturitas)
Source: Maturitas - April 29, 2020 Category: Primary Care Authors: H Depypere, A Dierickx, Velde F Van de, F Stanczyk, L Ottoy, J Delanghe, B Lapauw Source Type: research

Risk factors for insulin resistance in midlife Singaporean women
Insulin resistance, diabetes and their attendant complications have reached epidemic proportions in Asian countries. [1,2]. The precursor condition for diabetes is insulin resistance, and up to 20% of Singaporean women have increased insulin resistance, as measured by HOMA-IR; the lifetime risk is more than 50%. [3] Further, insulin resistance and type 2 diabetes develop at a younger age and at a lower body mass index in the Asian population than in Western populations. [1,2] Obesogenic diets and physical inactivity, leading to central obesity and lower muscle mass, are believed to underlie the higher prevalence of insulin...
Source: Maturitas - April 27, 2020 Category: Primary Care Authors: Inger Sundstr öm-Poromaa, Win Pa Pa Thu, Michael S. Kramer, Susan Logan, Jane A. Cauley, Eu-Leong Yong Source Type: research

Wearables beyond borders: A case study of barriers to gait assessment in low-resource settings
It is estimated that by 2030 the number of people suffering from Parkinson ’s disease (PD) will be approximately 9 million globally based on Western Europe’s (e.g. the United Kingdom,100% growth) [1]. Yet, robust screening and reporting of PD in developing countries is not mainstream, which may result in underestimated numbers. Motor symptoms (e.g. impaired performance of voluntary movements like walking/gait) have greatest impact on PD-associated costs at almost US$6000/patient in a developing country like Brazil [2] where many may remain undiagnosed and untreated [3]. (Source: Maturitas)
Source: Maturitas - April 26, 2020 Category: Primary Care Authors: A Godfrey, C Aranda, A Hussain, M Barreto, T Rocha, R Vit ório Source Type: research

Mediterranean diet, tobacco consumption and body composition during perimenopause. The FLAMENCO project
The perimenopause period (understood as the time just before, during and after menopause) usually occurs between 45-60 years old [1]. Perimenopause has been associated with greater overweight or obesity, loss of lean mass, increases in fat mass (FM), central body fat distribution and a higher waist circumference (WC) [2,3]. The adverse effects of android or truncal adiposity and the relatively diminished favourable effects of gynecoid or peripheral fat [4,5] might entail greater cardiometabolic risk during this period [6]. (Source: Maturitas)
Source: Maturitas - April 25, 2020 Category: Primary Care Authors: M. Flor-Alemany, N. Mar ín-Jiménez, T. Nestares, M. Borges-Cosic, P. Aranda, V.A. Aparicio Source Type: research

Effects of a patient-centered program including the cumulative-complexity model in women with chronic pelvic pain: a randomized controlled trial
Chronic pelvic pain (CPP) is a complex pain syndrome defined as noncyclical pain of at least 6 months ’ duration, located in the pelvis, lower back, buttocks and/or the anterior abdominal wall that affects 14% – 24% of women worldwide [1]. CPP may involve gynecologic, musculoskeletal, gastroenterologic and urologic systems, with significant presence of psychosocial and somatic comorbidities [2]. Women diagnosed with CPP frequently report a negative impact on quality of life, physical functioning, and the ability to work or perform activities of daily living [3]. (Source: Maturitas)
Source: Maturitas - April 25, 2020 Category: Primary Care Authors: M ª José Ariza-Mateos, Irene Cabrera-Martos, Laura López-López, Janet Rodríguez-Torres, Irene Torres-Sánchez, Marie Carmen Valenza Source Type: research

Effects of BRCA gene mutation on female reproductive potential: a systematic review
BRCA1 and BRCA2 genes belong to the family of ataxia-telangiectasia-mutated-mediated DNA repair genes that play a critical role in the DNA double-strand break repair. BRCA1 was first identified as a specific gene for early-onset breast cancer and ovarian cancer susceptibility in 1994 [1,2]. Nevertheless, the mutation of BRCA1 may not fully explain the majority of the two kinds of cancers, as only a small percentage of the cancers can detect the mutations of this gene [1,2]. At nearly the same time, the germline mutation of BRCA2 gene was identified in high-risk breast cancer families [3,4], indicating that the germline mut...
Source: Maturitas - April 23, 2020 Category: Primary Care Authors: Kai-Lun Hu, Siwen Wang, Xiaohang Ye, Dan Zhang Source Type: research

Prospective associations between physical activity levels and white matter integrity in older adults: results from the MAPT study
Aging is associated with a decline in white matter (WM) microstructural integrity [1], which, in turn, is associated with a decrease in cognition [2], Alzheimer ’s Disease [3] and dementia [4]. Diffusion tensor imaging (DTI) derived from functional MRI is the main tool for measuring the integrity of WM fibers; DTI provides values of fractional anisotropy (FA) and mean diffusivity (MD) [5], which provide an overall indication of brain function [5]. In line with this, decreased WM integrity is associated with worsened executive functioning [6], executive speed [6] and even slow gait speed [7]. (Source: Maturitas)
Source: Maturitas - April 23, 2020 Category: Primary Care Authors: Mathieu Maltais, Yves Rolland, Katherine Boisvert-Vigneault, Lisa Perus, Jean-Fran çois Mangin, Antoine Grigis, Marie Chupin, Ali Bouyahia, Audrey Gabelle, Julien Delrieux, Bruno Vellas, Barreto Philipe de Souto Source Type: research

Metformin intervention against ovarian toxicity during chemotherapy for early breast cancer: study protocol for a randomized double-blind placebo-controlled trial
Globally, the incidence of cancer still shows the trend of rapid growth, particularly in developing countries [1]. In China, breast cancer ranks first in the incidence of female population [2]. Over the past two decades, due to the rapid development of medical technology, the survival rate of cancer patients has been significantly improved. The most common cancer in women aged 15-59 is breast cancer, with an incidence of 24.2% and a 5-year survival rate of more than 70% [3]. However, with the significant improvement of the cure rate and survival rate of cancer patients, the survivors need to face quality of life problems, ...
Source: Maturitas - April 21, 2020 Category: Primary Care Authors: Jinjin Zhang, Xiangyi Ma, Ya Li, Ronghua Liu, Yan Li, Panshi Zhang, Wu Ren, Pengfei Cui, Bo Wang, Minli Zhang, Yan Jin, Xingrui Li, Shixuan Wang Source Type: research

Healthy lifestyle behaviors and transitions in frailty status among independent community-dwelling older adults: The Yabu cohort study
Frailty is defined as a state of increased vulnerability to stressors [1], and frailty can improve, as well as worsen, over time. A meta-analysis of 16 observational studies of older adults reported that frailty using frailty phenotype over a mean of 3.9 years (range: 1 –10 years) worsened in 29.1% and improved in 13.7% [2]. Another meta-analysis of improvement in frailty status in observational studies found that 23.3% of surviving respondents transitioned from pre-frail to robust and that 35.2% transitioned from frail to pre-frail or robust during a median foll ow-up of 3.0 years (range: 1–10 years) [3]. (Source: Maturitas)
Source: Maturitas - April 17, 2020 Category: Primary Care Authors: Takumi Abe, Yu Nofuji, Satoshi Seino, Hiroshi Murayama, Yuka Yoshida, Tomomi Tanigaki, Yuri Yokoyama, Miki Narita, Mariko Nishi, Akihiko Kitamura, Shoji Shinkai Source Type: research

Age at menopause and mortality in Taiwan: a cohort analysis
Menopause is the cessation of ovulation and marks the declining of sex hormones (e.g., estrogen) produced by the ovaries. A decline in estrogen in the body affects many organs and systems including cardiovascular and bone systems and increases disease risks, such as for metabolic syndrome [1], diabetes [2], cardiovascular diseases [3], osteoporosis and fractures [4 –7]. The association between menopause and health can also be explained by the “iron hypothesis” proposed by Sullivan [8]. According to the iron hypothesis, after menopause the body is exposed to high iron levels because of the dramatic alterat...
Source: Maturitas - April 17, 2020 Category: Primary Care Authors: Te-Yi Shen, Carol Strong, Tsung Yu Source Type: research

COVID-19: The forgotten priorities of the pandemic
By the end of March 2020, more than three-quarters of a million people had been diagnosed with COVID-19 and more than 39 000 had died [1], even though the disease was declared a pandemic by the World Health Organization (WHO) only earlierthat month. The pandemic has swiftly reached and affected all continents and countries around the globe. Measures taken to reduce the rapid spread of the SARS-CoV-2 virus [2] have extended the impact of the pandemic on health systems, economies and society everywhere in the world. (Source: Maturitas)
Source: Maturitas - April 14, 2020 Category: Primary Care Authors: Cristina Mesa Vieira, Oscar H. Franco, Carlos G ómez Restrepo, Thomas Abel Source Type: research

Non-surgical management of primary hyperparathyroidism in the aging population
Primary hyperparathyroidism (PHPT) is a common endocrine disorder, with particularly high prevalence in the aging population. Postmenopausal women and men aged 50 and older are mostly affected by PHPT, with a significant increase in its incidence with advancing age [1,2]. Recent studies have reported an average increase in the mean age of newly diagnosed women and men from 50-55 years in the 1980s to 60-65 in the period 1998-2010 [3,4]. (Source: Maturitas)
Source: Maturitas - April 13, 2020 Category: Primary Care Authors: Cristiana Cipriani, John P Bilezikian Source Type: research

Mediterranean diet and health: a systematic review of epidemiological studies and intervention trials
Healthy nutrition is increasingly considered to play a key role in reducing the risk of non-communicable diseases (NCD) and in health promotion [1]. Efforts to introduce a healthy diet at a global level have led to initiatives such as the EAT-Lancet Commission, which defined a universally healthy “optimal diet” in 2019. The principle of a healthy diet is that it should provide appropriate caloric intake and consist of a variety of plant-based foods, low amounts of animal source foods, unsaturated rather than saturated fats, and small amounts of refined grains, highly processed foods, and added sugars [2]. (Source: Maturitas)
Source: Maturitas - April 11, 2020 Category: Primary Care Authors: Mar ía Luz Sánchez-Sánchez, Alicia García-Vigara, Juan José Hidalgo-Mora, Miguel-Ángel García-Pérez, Juan Tarín, Antonio Cano Tags: Review article Source Type: research

Empower Women in Healthcare to move Women ’s Health forward
The United Nations has estimated that worldwide 985 million women in 2020 will be aged 50 and over. In 2050 the figure will rise to 1.65 billion. In 2020 the total female population is 3.8 billion and the estimate for 2050 is 4.8 billion [1]. Women ’s health issues are often limited to sexual and reproductive issues, whereas sex- and gender differences are relevant to many medical disciplines and all aspects of wellbeing and healthcare [2,3]. The time needed to assess comparable medical diagnoses has been found to be several years earlier in men compared to women. (Source: Maturitas)
Source: Maturitas - April 10, 2020 Category: Primary Care Authors: Angela H.E.M. Maas Source Type: research

Talking about genital problems with women aged over 70
A comprehensive understanding of the bio-medical and psychosocial mechanisms that underlie age-related deterioration of sexual function and behavior should be the primary goal of any concerned health care provider (HCP) in geriatric medicine. Many older women continue to be interest in sex and some of them look forward to have an agreeable discussion on sexual health in order to express their feelings and needs, especially if the HCP explores their concerns. However, discussing sex means to talk about genital problems with women aged over 70 and this may represent a challenge in daily practice because of several intraperso...
Source: Maturitas - April 6, 2020 Category: Primary Care Authors: Rossella E. Nappi Source Type: research

Editorial board
(Source: Maturitas)
Source: Maturitas - April 4, 2020 Category: Primary Care Source Type: research

Educational interventions on nutrition among older adults: A systematic review and meta-analysis of randomized clinical trials
Unhealthy food habits are associated with non-communicable diseases (NCD) [1 –3] and nutritional deficiencies [4]. According to the World Health Organization (WHO) [5], more than half of all deaths were due to ten main causes, with the leading killers being ischaemic heart disease and stroke. Diets characterized by a low intake of fruit and vegetable (FV) and fibre increas e the risk of hypertension, diabetes mellitus (DM), obesity, cardiovascular diseases (CVD), gastrointestinal cancers, nutritional deficiencies, pancreatic diseases, depression and the development of cognitive impairment and dementia [4–7]. (Source: Maturitas)
Source: Maturitas - March 19, 2020 Category: Primary Care Authors: Felix Jesus Neves, Luciana Yuki Tomita, Angela Sun Li Wu Liu, Solange Andreoni, Luiz Roberto Ramos Source Type: research

Insomnia, low sleep quality, and sleeping little are associated with frailty in Mexican women
Concerns about frailty are growing, especially in low income countries, where the prevalence reaches 17.4 % [1]. Prior evidence suggests that certain sleep disturbances are associated with frailty, such as low sleep quality [2], getting too little or too many hours of sleep [3 –5], insomnia symptoms [6] and severe nocturnal hypoxemia [7]. (Source: Maturitas)
Source: Maturitas - March 17, 2020 Category: Primary Care Authors: Karla Moreno-Tamayo, Betty Manrique-Espinoza, Lyzbeth Beatriz Ortiz-Barrios, Ángel Cárdenas-Bahena, Eliseo Ramírez-García, Sergio Sánchez-García Source Type: research

Early menopause is associated with increased risk of arterial hypertension: A systematic review and meta-analysis
Menopause is the consequence of ovarian reserve depletion leading to estrogen deficiency, clinically defined as completion of 12 months since the final menstrual period (FMP), except for cases with a history of bilateral oophorectomy [1]. Most studies have shown that menopausal transition is associated with a higher cardiovascular disease (CVD) risk [2,3], which is more evident in women with early menopause (EM; age at menopause (Source: Maturitas)
Source: Maturitas - March 17, 2020 Category: Primary Care Authors: Panagiotis Anagnostis, Patroklos Theocharis, Konstantinos Lallas, Georgios Konstantis, Konstantinos Mastrogiannis, Julia K. Bosdou, Irene Lambrinoudaki, John C. Stevenson, Dimitrios G. Goulis Tags: Review article Source Type: research

Menopause symptom management in women with dyslipidemias: an EMAS clinical guide
Worldwide, dyslipidemias are one of the leading causes of cardiovascular disease, mainly coronary heart disease [1]. Dyslipidemias are also associated with an increased risk of ischemic stroke [2]. Dyslipidemias embrace a wide constellation of lipid and lipoprotein abnormalities. Lipoproteins bind lipids and are involved in their transport. Lipid abnormalities include high serum concentrations of low-density lipoprotein (LDL) cholesterol (LDL-C) and/or triglycerides and/or low concentrations of high-density lipoprotein (HDL) cholesterol (HDL-C). (Source: Maturitas)
Source: Maturitas - March 17, 2020 Category: Primary Care Authors: Panagiotis Anagnostis, Johannes Bitzer, Antonio Cano, Iuliana Ceausu, Peter Chedraui, Fatih Durmusoglu, Risto Erkkola, Dimitrios G. Goulis, Angelica Lind én Hirschberg, Ludwig Kiesel, Patrice Lopes, Amos Pines, Mick van Trotsenburg, Irene Lambrinoudaki, Source Type: research

The role of stress and self-efficacy in somatic and psychological symptoms during the climacteric period – Is there a specific association?
The menopause as a natural phase during a woman ’s life with physical, mental, and social changes is currently in the scientific focus. A differentiated understanding of factors influencing the experience of this phase of life is important in order to avoid pathologisation with uncritical causal attribution of various physical or mental symptom s to the climacteric on the one hand and trivialisation with negation of symptom burden on the other. About one third of women have no or little symptoms in this phase of life, one third report moderate symptoms, one third show more severe impairments [1]. (Source: Maturitas)
Source: Maturitas - March 12, 2020 Category: Primary Care Authors: Kerstin Weidner, Antje Bittner, Manfred Beutel, Maren Goeckenjan, Elmar Br ähler, Susan Garthus-Niegel Source Type: research

Anti-M üllerian Hormone Levels and Risk of Cancer: A Systematic Review
Anti-M üllerian hormone (AMH) is considered to be a suitable marker for the assessment of ovarian function in women after cancer therapy, given its role in ovarian follicle development.1 Based on experimental research, it has been suggested that AMH is a potential therapeutic agent for cancer.2–4 In viv o and in vitro studies showed that administration of AMH induced apoptosis and inhibited tumor cell growth in models for ovarian5, breast6,7 and prostate7,8 cancer. The involvement of AMH in processes like cell proliferation and apoptosis, raises the question whether AMH might also inhibit tumor dev elopment, esp...
Source: Maturitas - March 9, 2020 Category: Primary Care Authors: Ren ée M.G. Verdiesen, Carla H. van Gils, Yvonne T. van der Schouw, N. Charlotte Onland-Moret Source Type: research