Comprehensive analysis of long non-coding RNA and mRNA expression profile in rectal cancer.
Abstract BACKGROUND: Rectal cancer (RC) is a malignant tumor that seriously threatens human health. Long non-coding RNAs (lncRNAs) play a vital role in tumor regulation. Nevertheless, their exact expression features and functions remain obscure, and therefore was the aim of the current study. METHODS: We utilized the Affymetrix human GeneChip to screen differentially expressed profiles of lncRNAs and mRNAs from the cancer tissues and matched paracancer tissues of 6 RC patients. Gene Ontology (GO) and pathway enrichment analyses identified crucial functions and pathways of the aberrantly expressed mRNAs. We us...
Source: Chinese Medical Journal - March 27, 2020 Category: General Medicine Authors: Wang DZ, Chen GY, Li YF, Zhang NW Tags: Chin Med J (Engl) Source Type: research

In Silico assessment of the impact of 2019 novel coronavirus (2019-nCoV) genomic variation on published real-time quantitative polymerase chain reaction detection assays.
PMID: 32221132 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 26, 2020 Category: General Medicine Authors: Fan H, Zhang XL, Zhang YW, Huang Y, Teng Y, Guo Y, Mi ZQ, Yang RF, Song YJ, Cui YJ Tags: Chin Med J (Engl) Source Type: research

Detection of serum immunoglobulin M and immunoglobulin G antibodies in 2019-novel coronavirus infected cases from different stages.
PMID: 32221133 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 26, 2020 Category: General Medicine Authors: Gao HX, Li YN, Xu ZG, Wang YL, Wang HB, Cao JF, Yuan DQ, Li L, Xu Y, Zhang Z, Huang Y, Lu JH, Liu YZ, Dai EH Tags: Chin Med J (Engl) Source Type: research

A novel treatment for psoriatic arthritis: Janus kinase inhibitors.
Abstract Psoriatic arthritis (PsA) is a type of chronic inflammatory arthritis which is associated with psoriasis. The early recognition and treatment for PsA are of critical importance. Janus kinase (JAK) inhibitors, as a kind of orally small molecules, have emerged as an encouraging class of drug in PsA treatment. This review provides a discussion of the role and current status of JAK inhibitors in the control of PsA. There are three JAK inhibitors approved for use in autoimmune diseases, for example, tofacitinib, baricitinib, and upadacitinib, and only tofacitinib has been approved in PsA treatment. The clinica...
Source: Chinese Medical Journal - March 23, 2020 Category: General Medicine Authors: Chen M, Dai SM Tags: Chin Med J (Engl) Source Type: research

Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study.
This study is performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). METHODS: Clinical data were collected from two tertiary hospitals in Wuhan. A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and compare them with recovered patients (recovered group). Continuous variables were analyzed using the Mann-Whitney U test. Categorical variables were analyzed by χ test or Fisher's exact tests as appropriate. RESULTS: Our study enrolled 109 COVID-19 pat...
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L, Wang K, Leng F, Wei S, Chen L, Liu HG Tags: Chin Med J (Engl) Source Type: research

Effect of subarachnoid anesthesia combined with propofol target-controlled infusion on blood loss and transfusion for posterior total hip arthroplasty in elderly patients.
This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patients in comparison with combined spinal-epidural anesthesia (CSEA) or GA. METHODS: Totally, 240 patients (aged ≥65 years, American Society of Anesthesiologists [ASA] I-III) scheduled for posterior THA were enrolled from September 1st, 2017 to March 1st, 2018. All cases were randomly divided into three groups to receive CSEA (group C, n = 80), GA (group G, n = 80), or subarachnoid anesthesia and propofol TC...
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Xu CS, Qu XD, Qu ZJ, Wang G, Wang HJ Tags: Chin Med J (Engl) Source Type: research

Connective tissue growth factor as an unfavorable prognostic marker promotes the proliferation, migration, and invasion of gliomas.
This study aimed to verify that connective tissue growth factor (CTGF) is associated with the clinical prognosis of glioma, also to analyze the effect of CTGF on the biological function. METHODS: In this study, glioma and non-tumor tissue samples were obtained in 2012 to 2014 from the Department of Neurosurgery of Nanfang Hospital of Southern Medical University, Guangzhou, China. Based on messenger RNA (mRNA) data from the Cancer Genome Atlas (TCGA) and CCGA dataset, combined with related clinical information, we detected the expression of CTGF mRNA in glioma and assessed its effect on the prognosis of glioma patients...
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Song ZB, Yang HP, Xu AQ, Zhan ZM, Song Y, Li ZY Tags: Chin Med J (Engl) Source Type: research

Prevalence of combined growth hormone deficiency and celiac disease among Saudi Arabian children with short stature: a tertiary care center experience.
PMID: 32197032 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Qutub LM, Saadah OI Tags: Chin Med J (Engl) Source Type: research

Recurrent hemichorea in a patient with diabetes and anti-phospholipid syndrome: a case report.
PMID: 32197033 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Wang DM, Su S, Lin ZZ, Lai LY, Wu YM, Wang SN Tags: Chin Med J (Engl) Source Type: research

Development of the organ donation and transplantation system in China.
PMID: 32195670 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 18, 2020 Category: General Medicine Authors: Shi BY, Liu ZJ, Yu T Tags: Chin Med J (Engl) Source Type: research

Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases.
This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM...
Source: Chinese Medical Journal - March 18, 2020 Category: General Medicine Authors: Duan HJ, Li XY, Liu C, Deng XL Tags: Chin Med J (Engl) Source Type: research

Prolonged progression-free survival and overall survival are associated with diabetes mellitus but inversely associated with levels of blood glucose in patients with lung cancer.
This study assessed progression-free survival (PFS)/OS in lung cancer patients with or without DM and tentatively analyzed the impact of blood glucose levels on PFS/OS in lung cancer patients. METHODS: Data were collected from lung cancer patients based upon admission records from January 2010 to January 2012 and follow-up records from January 2010 to January 2015 in the Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai. The data included patient sex, age, body mass index (BMI), smoking status, history of DM, level of blood glucose, pathological type, clinical stage of cancer, chemothera...
Source: Chinese Medical Journal - March 18, 2020 Category: General Medicine Authors: Wang NF, Tang HM, Liu FL, Hong QY Tags: Chin Med J (Engl) Source Type: research

Advancements in medical and surgical treatments of Takayasu arteritis-induced renal arteritis: a systematic review.
CONCLUSIONS: Patients with TARA should benefit both from medical treatments and from surgical treatments comprehensively and sequentially. Multidisciplinary team coordination is recommended especially in patients with severe complications. PMID: 32187045 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Dai XM, Yin MM, Liu Y, Ma LL, Ying J, Jiang LD Tags: Chin Med J (Engl) Source Type: research

Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
PMID: 32187046 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Li YT, Du HZ, Wang CY, Zhu TN, Pan BJ, Zhang L Tags: Chin Med J (Engl) Source Type: research

Long-term outcomes of peroral endoscopic myotomy in achalasia patients with a minimum follow-up of 7 years.
PMID: 32187047 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Zhang WG, Chai NL, Zhai YQ, Linghu EQ, Li HK Tags: Chin Med J (Engl) Source Type: research

Paraneoplastic cerebellar degeneration: initial presentation of mucosa-associated lymphoid tissue lymphoma in a patient with primary Sj ögren syndrome.
Paraneoplastic cerebellar degeneration: initial presentation of mucosa-associated lymphoid tissue lymphoma in a patient with primary Sjögren syndrome. Chin Med J (Engl). 2020 Mar 16;: Authors: Cao X, Xu CG PMID: 32187048 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Cao X, Xu CG Tags: Chin Med J (Engl) Source Type: research

Effect of decompression range on decompression limit of cervical laminoplasty.
This study aimed to determine the decompression limit of posterior surgery and the effect of the decompression range. METHODS: We retrospectively reviewed the data of 129 patients who underwent cervical open-door laminoplasty through 2008 to 2012 and were grouped as follows: C4-C7 (n = 11), C3-C6 (n = 61), C3-C7 (n = 32), and C2-C7 (n = 25). According to the relative location of spinal levels within a decompression range, the type of decompression at a given level was categorized as external decompression (ED; achieved at the levels located immediately external to the decompression range margin), inter...
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Diao YZ, Yu M, Zhang FS, Sun Y, Wang SB, Zhang L, Pan SF, Liu ZJ, Li WS Tags: Chin Med J (Engl) Source Type: research

Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
CONCLUSIONS: KIF22 protein level was negatively correlated with prognosis. KIF22 knockdown might inhibit proliferation and metastasis of GC cells via the MAPK-ERK signaling pathway. PMID: 32187050 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Yu ZY, Jiang XY, Zhao RR, Qin JJ, Luo CJ, Ren YX, Ren W, Ma ZJ, Jiao ZY Tags: Chin Med J (Engl) Source Type: research

Toward wiping out osteoarthritis in China: research highlights.
PMID: 32187051 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Ye ZZ, Zhang ZY, Li ZG, Huang CB, Zhang Y Tags: Chin Med J (Engl) Source Type: research

Glucose-6-phosphate isomerase is associated with disease activity and declines in response to infliximab treatment in rheumatoid arthritis.
Abstract BACKGROUND: Rheumatoid arthritis (RA), a systemic autoimmune disease characterized by synovial inflammation, can cause cartilage and bone damage as well as disability. The aim of this study was to explore whether serum glucose-6-phosphate isomerase (GPI) is correlated with disease activity and the value of GPI in the evaluation of infliximab treatment in patients with RA. METHODS: Sixty-two patients with RA who had an inadequate response to methotrexate (MTX) were enrolled in Peking University People's Hospital from July 1, 2016 to July 31, 2018. Infliximab (3 mg/kg, intravenous at weeks 0, 2, and 6 ...
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Xu J, Zhang XY, Li R, Liu J, Ye H, Zhang XW, Li ZG Tags: Chin Med J (Engl) Source Type: research

Treatment satisfaction with rheumatoid arthritis in patients with different disease severity and financial burden: A subgroup analysis of a nationwide survey in China.
This study aimed to analyze the satisfaction with drug therapies for RA according to the levels of disease severity (patient-assessed) and proportions of treatment cost to household income. METHODS: This was a subgroup study of a cross-sectional study in patients with RA and their physicians. The patients were subdivided into different subgroups based on their self-assessed severity of RA and on the proportions of treatment cost to household income (50%). The Treatment Satisfaction Questionnaire for Medication version II was used to assess patients' treatment satisfaction. RESULTS: When considering all medication...
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Li HB, Wu LJ, Jiang N, Yang PT, Liu SY, Shi XF, Fang YF, Zhao Y, Xu J, Jiang ZY, Wu ZB, Duan XW, Wang Q, Li MT, Tian XP, Zeng XF Tags: Chin Med J (Engl) Source Type: research

Advances in the role of helper T cells in autoimmune diseases.
Abstract Autoimmune diseases are primary immune diseases in which autoreactive antibodies or sensitized lymphocytes destroy and damage tissue and cellular components, resulting in tissue damage and organ dysfunction. Helper T cells may be involved in the pathogenesis of autoimmune diseases under certain conditions. This review summarizes recent research on the role of helper T cells in autoimmune diseases from two aspects, helper T cell-mediated production of autoantibodies by B cells and helper T cell-induced activation of abnormal lymphocytes, and provides ideas for the treatment of autoimmune diseases. The abno...
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Zhang XM, Liu CY, Shao ZH Tags: Chin Med J (Engl) Source Type: research

Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis.
Abstract LncRNA plays a contributory role in rheumatoid arthritis (RA). In this review, we summarized the current findings of lncRNAs in RA, including cellular function and the potential mechanisms. Serum lncRNA levels are associated with serum proinflammatory cytokines and disease activity. LncRNAs regulate proliferation, migration, invasion and apoptosis of RA fibroblast-like synoviocytes (FLSs), modulate the differentiation of T lymphocytes and macrophages, and affect bone formation-destruction balance of chondrocytes. Besides, lncRNAs are involved in inflammation and cell motivation signaling pathways. In-dept...
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Lao MX, Xu HS Tags: Chin Med J (Engl) Source Type: research

Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease.
PMID: 32187056 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Su SS, Lin YF, Zhou H Tags: Chin Med J (Engl) Source Type: research

Corrigendum: Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder: a randomized controlled trial.
Authors: PMID: 32187057 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Tags: Chin Med J (Engl) Source Type: research

Expert consensus on management principles of orthopedic emergency in the epidemic of Corona Virus Disease 2019.
Limb Reconstruction Branch of Chinese Orthopaedic Association; Trauma Expert Committee of Chinese Association of Orthopedic Surgeons PMID: 32187058 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 16, 2020 Category: General Medicine Authors: Tang PF, Hou ZY, Wu XB, Zhang CQ, Wang JW, Xing X, Shao ZW, Yu AX, Wang G, Chen B, Zhang P, Hu YJ, Wang BW, Guo XD, Tang X, Zhou DS, Liu F, Chen AM, Zhang K, Li KN, Zhu YB, Orthopedic Trauma Branch of Chinese Orthopaedic Association; External Fixation and Tags: Chin Med J (Engl) Source Type: research

Therapeutic effects of compound herba Houttuyniae in type 2 diabetic rats.
PMID: 32187059 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 13, 2020 Category: General Medicine Authors: Shao SC, Wang HY Tags: Chin Med J (Engl) Source Type: research

Subungual squamous cell carcinoma treated by topical photodynamic therapy.
PMID: 32187060 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 13, 2020 Category: General Medicine Authors: An Q, Zheng S, Zhang L, Gao XH, Li JH Tags: Chin Med J (Engl) Source Type: research

Platelet-rich fibrin membrane nerve guidance conduit: a potentially promising method for peripheral nerve injuries.
PMID: 32187061 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 13, 2020 Category: General Medicine Authors: Huang ML, Zhai Z, Chen ZX, Yang XN, Qi ZL Tags: Chin Med J (Engl) Source Type: research

P45 technology reveals bow-and-arrow sign in human ankle.
PMID: 32187062 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 13, 2020 Category: General Medicine Authors: Jiang WB, Li C, Sun SZ, Chen W, Yu SB, Sui HJ Tags: Chin Med J (Engl) Source Type: research

Maternal exercise and its beneficial effects on glucose metabolism in offspring.
Abstract It shows that detrimental exposures and conditions in mothers can lead to the development of obesity and type 2 diabetes in offspring. This can lead to a vicious cycle of metabolic dysfunction, where rising rates of obesity, pre-diabetes, and diabetes in individuals of reproductive age, propagating risks to subsequent generations. It is well established that regular exercise has important health benefits for people with obesity and type 2 diabetes. Recently, increasing studies aim to examine the effects of maternal exercise on metabolic health in offspring. This review aims to demonstrate the evidence lin...
Source: Chinese Medical Journal - March 13, 2020 Category: General Medicine Authors: Zheng J, Zhou LY, Xiao XH Tags: Chin Med J (Engl) Source Type: research

Intracoronary pressure gradient measurement in acute myocardial infarction patients with the no-reflow phenomenon during primary percutaneous coronary intervention.
This study aimed to measure the intracoronary pressure gradient in the no-reflow artery during emergent percutaneous coronary intervention and explore the potential mechanism of no-reflow. METHODS: From September 1st, 2018 to June 30th, 2019, intracoronary pressure in acute myocardial infarction patient was continuously measured by aspiration catheter from distal to proximal segment in the Department of Coronary Care Unit, Tianjin Chest Hospital, respectively in no-reflow arteries (no-reflow group) and arteries with thrombolysis in myocardial infarction-3 flow (control group). At least 12 cardiac cycles were consecuti...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Gao MD, Zhang EY, Liu YY, Li XW, Xiao JY, Sun GY, Liu Y Tags: Chin Med J (Engl) Source Type: research

Autoimmune polyendocrine syndrome type 4 with systemic lupus erythematosus and anti-phospholipid syndrome.
PMID: 32149761 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Wang Y, Zhao J, Zhang TT, Ma XW, Zhang JQ, Zhang ZL Tags: Chin Med J (Engl) Source Type: research

Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor- β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro. Chin Med J (Engl). 2020 Mar 06;: Authors: He J, Jiang YL, Wang Y, Tian XJ, Sun SR Abstract BACKGROUND: The use of microRNAs in the therapy of kidney disease is hampered by the difficulties in their effective delivery. Micro-vesicles (MVs) are known as natural carriers of small RNAs. Our prior research has demonstrated that MVs isolated from mesenchymal stem cells (MSCs) are capable of attenuating kidney injur...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: He J, Jiang YL, Wang Y, Tian XJ, Sun SR Tags: Chin Med J (Engl) Source Type: research

Clinical utility of characterizing intestinal flora in septic kidney injury.
Abstract The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such chang...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Yuan JJ, Chang XN, Li M, Yuan QX, Yang XL Tags: Chin Med J (Engl) Source Type: research

Desflurane anesthesia compared with total intravenous anesthesia on anesthesia-controlled operating room time in ambulatory surgery following strabotomy: a randomized controlled study.
This study was aimed to compare the ACT of desflurane with that of propofol-remifentanil in strabismus ambulatory surgery. METHODS: From November 2016 to December 2017, a total of 200 strabismus patients (aged 18-60 years old, and scheduled for elective ambulatory surgery at Zhongshan Ophthalmic Center) were randomly assigned to receive either propofol-based TIVA (group TIVA) or desflurane anesthesia (group DES) for maintenance of anesthesia. The primary outcome was the extubation time. Secondary outcomes included surgical time, anesthetic time, OR exit time, and Phase I and II recovery time. The intraoperative incide...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Zhu YL, Shen WH, Chen QR, Ye HJ, Huang JX, Kang Y, Chi W, Gan XL Tags: Chin Med J (Engl) Source Type: research

Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes.
This study recruited consecutive patients who underwent coronary computed tomography (CT) angiography (CCTA) between October 2016 and November 2017. Personal information including conventional cardiovascular risk factors was collected. Plaque phenotypes were automatically calculated for volume of different component. The volume of different plaque was compared between DM patients and those without DM. RESULTS: Among 6381 patients, 931 (14.59%) were diagnosed with DM. The prevalence of plaque in DM subjects was higher compared with nondiabetic group significantly (48.34% vs. 33.01%, χ = 81.84, P 
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Hou ZH, Lu B, Li ZN, An YQ, Gao Y, Yin WH, Budoff MJ Tags: Chin Med J (Engl) Source Type: research

Lessons from transulnar access for repeat percutaneous coronary intervention after radial artery occlusion.
PMID: 32149766 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Bi XL, Wang QS Tags: Chin Med J (Engl) Source Type: research

Differences of maternal mortality rate between Shanghai and New York city from the perspective of regulatory policy.
This study aims to adopt a quantitative evaluation model to analyze whether RP differences contribute to the different MMRs of the two cities. METHODS: Based on collection of all publicly released policy documents regarding maternal health in the two cities, we assessed and compared the status of their maternal health care RPs from 2006 to 2017 through a series of quantitative indicators as regulatory elements coverage rate (RECR), departmental responsibility clarity rate (DRCR), and accountability mechanism clarity rate (AMCR), based on two characteristics of comprehensiveness and effectiveness of RPs. Pearson correl...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Li L, Li CY, Zhou QY, Pu C, Xu LZ, Xu TQ, Hao C, Hu Z, Hao M Tags: Chin Med J (Engl) Source Type: research

A confirmed asymptomatic carrier of 2019 novel coronavirus (SARS-CoV-2).
PMID: 32149768 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Luo SH, Liu W, Liu ZJ, Zheng XY, Hong CX, Liu ZR, Liu J, Weng JP Tags: Chin Med J (Engl) Source Type: research

Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model.
This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV related coronavirus model. METHODS: A 2019-nCoV related pangolin coronavirus GX_P2V/pangolin/2017/ Guangxi was described. Whether GX_P2X uses angiotensin-converting enzyme 2 (ACE2) as the cell receptor was investigated by using small interfering RNA (siRNA) -mediated silencing of ACE2. The pangolin coronavirus model was used to identify drug candidates for treating 2019-nCoV infection. Two libraries of 2406 clinically approved drugs were screened for their ability to inhibit cytopathic eff...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Fan HH, Wang LQ, Liu WL, An XP, Liu ZD, He XQ, Song LH, Tong YG Tags: Chin Med J (Engl) Source Type: research

High-throughput sequencing for confirmation of suspected 2019-nCoV infection identified by fluorescence quantitative polymerase chain reaction.
PMID: 32149770 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Guan WD, Chen LP, Ye F, Ye D, Wu SG, Zhou HX, He JY, Yang CG, Zeng ZQ, Wang YT, Li RF, Du QL, Liang XL, Ma QH, Yang ZF Tags: Chin Med J (Engl) Source Type: research

A case of 2019 novel coronavirus infected pneumonia with twice negative 2019-nCoV nucleic acid testing within 8 days.
PMID: 32149771 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Ruan ZR, Gong P, Han W, Huang MQ, Han M Tags: Chin Med J (Engl) Source Type: research

Comparative effectiveness and safety of ribavirin plus interferon-alpha, lopinavir/ritonavir plus interferon-alpha and ribavirin plus lopinavir/ritonavir plus interferon-alphain in patients with mild to moderate novel coronavirus pneumonia.
PMID: 32149772 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Zeng YM, Xu XL, He XQ, Tang SQ, Li Y, Huang YQ, Harypursat V, Chen YK Tags: Chin Med J (Engl) Source Type: research

Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: protocol of a randomized controlled trial.
In this study, we hope to discover evidence either supporting or opposing the systemic therapeutic administration of glucocorticoids in severe coronavirus disease 2019 (COVID-19) patients. TRIAL REGISTRATION: ClinicalTrials.gov, ChiCTR2000029386, http://www.chictr.org.cn/showproj.aspx?proj=48777. PMID: 32149773 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Zhou YH, Qin YY, Lu YQ, Sun F, Yang S, Harypursat V, Tang SQ, Huang YQ, He XQ, Zeng YM, Li Y, Xu XL, Zhao T, Chen YK Tags: Chin Med J (Engl) Source Type: research

Clinical evidence and treatment requirements related to heart failure in type 2 diabetes mellitus.
PMID: 32149774 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Cai XL, Wang XQ, Ji LN Tags: Chin Med J (Engl) Source Type: research

Obstetric anesthesia in China: associated challenges and long-term goals.
PMID: 32142490 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Wu J, Yao SL Tags: Chin Med J (Engl) Source Type: research

Optimum interval time of programmed intermittent epidural bolus of ropivacaine 0.08% with sufentanyl 0.3 μg/mL for labor analgesia: a biased-coin up-and-down sequential allocation trial.
CONCLUSION: With a fixed 10 mL dose of ropivacaine 0.08% with sufentanyl 0.3 μg/mL, the optimal PIEB interval is about 42 min. Further studies are warranted to define the efficacy of this regimen throughout all stages of labor. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR1900022199; http://www.chictr.org.cn/com/25/historyversionpuben.aspx?regno=ChiCTR1900022199. PMID: 32142491 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Zhou SQ, Wang J, Du WJ, Song YJ, Xu ZD, Liu ZQ Tags: Chin Med J (Engl) Source Type: research

A comparative study of three concentrations of intravenous nalbuphine combined with hydromorphone for post-cesarean delivery analgesia.
Abstract BACKGROUND: Nalbuphine has been suggested to be used for post-cesarean section (CS) intravenous analgesia. However, ideal concentration of nalbuphine for such analgesia remains unclear. The present study was conducted to explore an ideal concentration of nalbuphine for post-CS intravenous analgesia by evaluating the analgesic effects and side-effects of three different concentrations of nalbuphine combined with hydromorphone for post-CS intravenous analgesia in healthy parturients. METHODS: One-hundred-and-fourteen parturients undergoing elective CS were randomly allocated to one of three groups (38 ...
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Huang CY, Li SX, Yang MJ, Xu LL, Chen XZ Tags: Chin Med J (Engl) Source Type: research

Contact heat evoked potentials in knowledge workers and unskilled labors.
CONCLUSIONS: Our study found that significantly prolonged N2 latency and P2 latency and significantly decreased N2-P2 amplitude in the distal leg and the volar forearm in unskilled labors as to knowledge workers. PMID: 32142493 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Sun B, Li YR, Wang HF, Cui F, Ling L, Yang F, Chen ZH, Huang XS Tags: Chin Med J (Engl) Source Type: research