Dermoscopy of papular elastorrhexis.
PMID: 33410613 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Zhao JQ, Xu Z, Wang B, Li YJ, Zhang GQ Tags: Chin Med J (Engl) Source Type: research

Association between acne and smoking: systematic review and meta-analysis of observational studies.
PMID: 33410614 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Zhang JZ, Xiang F, Yu SR, Luo D, Li TT, Kang XJ Tags: Chin Med J (Engl) Source Type: research

Immunotherapy-related toxicity in lung cancer: clinical characteristics and managing strategy.
PMID: 33410615 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Luo WX, Yang L, Li WM Tags: Chin Med J (Engl) Source Type: research

Comparable efficacy of 100 mg aspirin twice daily and rivaroxaban for venous thromboembolism prophylaxis following primary total hip arthroplasty: a randomized controlled trial.
CONCLUSION: In terms of safety and efficacy, the prophylactic use of 100 mg aspirin twice daily was not statistically different from that of rivaroxaban in preventing VTE and reducing the risk of blood loss following elective primary THA. This supports the use of aspirin chemoprophylaxis following THA as a less expensive and more widely available option for future THAs. TRIAL REGISTRATION: Chictr.org, ChiCTR18000202894; http://www.chictr.org.cn/showproj.aspx?proj=33284. PMID: 33410616 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Ren Y, Cao SL, Li Z, Luo T, Feng B, Weng XS Tags: Chin Med J (Engl) Source Type: research

Coronavirus diseases 2019 and kidney injury: a brief review based on current evidence.
PMID: 33410617 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Yang G, Wang H, Liu Y, Hou JB, Xu GG, Cao F, Cheng QL Tags: Chin Med J (Engl) Source Type: research

Local thrombolysis combined with balloon dilation for patients with severe cerebral venous sinus thrombosis.
PMID: 33410618 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Qiu MJ, Song SJ, Gao F Tags: Chin Med J (Engl) Source Type: research

Sustained AMP-activated protein kinase activation attenuates the activity of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in mice exposed to chronic stress.
PMID: 33410619 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Yi LT, Wang SS, Cheng J, Chen M, Zhu JX, Li CF, Dong SQ, Liu Q Tags: Chin Med J (Engl) Source Type: research

Bullous prurigo pigmentosa following a ketogenic diet.
PMID: 33410620 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Mao DD, Chen X, Zhang H, Jin J, Chen X, Wen GD Tags: Chin Med J (Engl) Source Type: research

Preliminary adipose removal did not prevent diet-induced metabolic disorders in mice.
CONCLUSIONS: Our data suggest that removal of epididymal adipose or subcutaneous adipose alone or in combination before the onset of obesity did not protect against hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in LDL-R KO mice fed with a HFD. Hence, adipose removal possibly does not represent a potential approach in preventing obesity-related metabolic disorders in the obesity-susceptible population. PMID: 33410621 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Liu L, Liang CX, Wang XW, Pei KX, Ma XD, Zhang CX, Dong JH, Gao MM, Liao JW Tags: Chin Med J (Engl) Source Type: research

Treatment of liver metastases in patients with epithelial ovarian cancer.
PMID: 33410622 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Deng H, Zhu HL, Li Y, Wang Y, Wu Y, Cui H, Wang JL, Li XP Tags: Chin Med J (Engl) Source Type: research

A study of follicular development and oocyte maturity predicted by transvaginal ultrasound on the day of human chorionic gonadotropin injection.
PMID: 33410623 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Chen X, Liang XW, Fang JH, Chen ZY Tags: Chin Med J (Engl) Source Type: research

Detection of infectious pathogens located in the peripheral lung field by metagenomic next-generation sequencing combined with virtual bronchoscopic navigation.
PMID: 33410624 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Xu SF, Tian Q, Tian YL, Feng J, Zhao J, Yin XB Tags: Chin Med J (Engl) Source Type: research

Rationale, design, and baseline characteristics of Chinese registry in early detection and risk stratification of coronary plaques (C-STRAT) study.
PMID: 33410625 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Yang JJ, Shan DK, Xu L, Liang JF, Wang ZQ, Zhang M, Li M, Yang WJ, Xu JR, Zhang YG, Xia LM, Wang LH, Hu HJ, Yang ZG, Li T, Tian Q, Lyu XD, Chen YD Tags: Chin Med J (Engl) Source Type: research

Psychological reactions of healthcare workers deployed to Wuhan from Shanxi province and how they cope during coronavirus disease 2019 (COVID-19) outbreak.
PMID: 33410626 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Dong LN, Zhao YL, Liu Y, Wu YZ, Wang JP Tags: Chin Med J (Engl) Source Type: research

Pandemic of the aging society - sporadic cerebral small vessel disease.
Abstract ABSTRACT: Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, bi...
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Lau AYL, Ip BYM, Ko H, Lam BYK, Shi L, Ma KKY, Au LWC, Soo YOY, Leung TWH, Wong A, Mok VCT Tags: Chin Med J (Engl) Source Type: research

The prevalence and associated factors of simple hepatic cysts in Shanghai: a population-based cross-sectional study.
PMID: 33410628 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Xu WP, Wang XH, Wu SP, Shi PM, Yuan ZL, Guo YB, Zeng X, Xie WF Tags: Chin Med J (Engl) Source Type: research

Identification of a serum three-microRNA signature for cervical cancer diagnosis.
PMID: 33410629 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Cao MM, Liu QX, Zou X, Fan XC, Liu C, Zhang SY, Wang TS, Li CY, Zhang C, Geng XN, Liu P, Zhu W Tags: Chin Med J (Engl) Source Type: research

Construction of potential idiopathic pulmonary fibrosis related microRNA and messenger RNA regulatory network.
PMID: 33410630 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Zhang YF, Gu LN, Qi J, Xia QQ, Tian LJ, Jiang WL, Cao MS Tags: Chin Med J (Engl) Source Type: research

Anterior thalamic nuclei deep brain stimulation inhibits mossy fiber sprouting via 3',5'-cyclic adenosine monophosphate protein kinase A signaling pathway in a chronic epileptic monkey model.
This study aimed to investigate the effect of ATN-DBS on MFS, as well as potential signaling pathways by a kainic acid (KA)-induced epileptic model. METHODS: Twenty-four rhesus monkeys were randomly assigned to control, epilepsy (EP), EP-sham-DBS, and EP-DBS groups. KA was injected to establish the chronic epileptic model. The left ATN was implanted with a DBS lead and stimulated for 8 weeks. Enzyme-linked immunosorbent assay, Western blotting, and immunofluorescence staining were used to evaluate MFS and levels of potential molecular mediators in the hippocampus. One-way analysis of variance, followed by the Tukey po...
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Du TT, Chen YC, Zhu GY, Liu DF, Liu YY, Yuan TS, Zhang X, Zhang JG Tags: Chin Med J (Engl) Source Type: research

Clinical characteristics of Chlamydia psittaci pneumonia.
PMID: 33410632 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Kong CY, Zhu J, Lu JJ, Xu ZH Tags: Chin Med J (Engl) Source Type: research

Cosinor-rhythmometry for 24-h urinary sodium, potassium, creatinine excretion in the Chinese adult population.
CONCLUSION: It is necessary to consider the circadian rhythm of urinary sodium, potassium, and creatinine excretion in adults while exploring the estimation model for 24-h urinary sodium excretion using spot urine. PMID: 33410633 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Peng YG, Feng JJ, Zhang Y, Li K, Cai SY, Yan RH, Peng XX Tags: Chin Med J (Engl) Source Type: research

Ruxolitinib treatment for bronchiolitis obliterans syndrome following hematopoietic stem cell transplant in a patient with primary hemophagocytic lymphohistiocytosis.
PMID: 33410634 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Meng GQ, Wang YN, Wang JS, Wang Z Tags: Chin Med J (Engl) Source Type: research

Green channel of human organ transport improved the utilization rate of Chinese citizens' donated lungs: a single-center data analysis.
PMID: 33410635 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Li XS, Hu CX, Liu F, Huang J, Liu D, Yu ZH, Li HX, Zhao J, Ma QL, Chen JY Tags: Chin Med J (Engl) Source Type: research

Identification of KIF20A as a tumor biomarker and forwarder of clear cell renal cell carcinoma.
PMID: 33410636 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Xiao W, Chen K, Liang HG, Zhang XP Tags: Chin Med J (Engl) Source Type: research

Divergent detection rates of Fecal immunochemical test and questionnaire-based risk assessment for detecting proximal and distal advanced adenomas.
PMID: 33410637 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Chen HD, Lu M, Zhang YH, Dai M Tags: Chin Med J (Engl) Source Type: research

A long and winding road to understand latent autoimmune diabetes in adults.
PMID: 33395070 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Luo SM, Liu BW, Yin WF, Li X, Zhou ZG Tags: Chin Med J (Engl) Source Type: research

Neutrophil to lymphocyte ratio is a prognosis factor for post-operative pneumonia in aneurysmal subarachnoid hemorrhage patients.
Abstract BACKGROUND: Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm (post-operative pneumonia [POP]) in patients with aneurysmal subarachnoid hemorrhage (aSAH) have been studied, the predictive model of POP after aSAH has still not been well established. Thus, the aim of this study was to assess the feasibility of using admission neutrophil to lymphocyte ratio (NLR) to predict the occurrence of POP in aSAH patients. METHODS: We evaluated 711 aSAH patients who were enrolled in a prospective observational study and collected admission blood cell counts data. We analyze...
Source: Chinese Medical Journal - December 24, 2020 Category: General Medicine Authors: Chen Y, Lian BQ, Peng L, Ding CY, Lin YX, Yu LH, Wang DL, Kang DZ Tags: Chin Med J (Engl) Source Type: research

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy.
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, placing an increasing burden on human health. NAFLD is a complex multifactorial disease involving genetic, metabolic, and environmental factors. It is closely associated with metabolic syndrome, obesity, and type 2 diabetes, of which insulin resistance is the main pathophysiological mechanism. Over the past few decades, investigation of the pathogenesis, diagnosis, and treatments has revealed different aspects of NAFLD, challenging the accuracy of definition and therapeutic strategy for the clinical practice. Rece...
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Xian YX, Weng JP, Xu F Tags: Chin Med J (Engl) Source Type: research

Using posterior part of the deltoid muscle as receptor and quality control with intra-operative electrophysiological examination in targeted muscle reinnervation for high-level upper extremity amputees.
PMID: 33323807 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Yin HW, Feng JT, Shen YD, Wang YS, Zhang DG, Xu WD Tags: Chin Med J (Engl) Source Type: research

Laparoscopic metroplasty for bicorporeal uterus: surgical techniques and outcomes.
PMID: 33323808 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Zhou QY, Saravelos S, Huang XW, Ma N, Li T, Xia EL Tags: Chin Med J (Engl) Source Type: research

Hysteroscopic endometrial biopsy with immunohistochemistry in the diagnosis of endometritis.
PMID: 33323809 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Zhang Y, Li WY, Lu J Tags: Chin Med J (Engl) Source Type: research

Infective endocarditis in obstructive hypertrophic cardiomyopathy: a case series and literature review.
PMID: 33323810 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Wu ZW, Yan H Tags: Chin Med J (Engl) Source Type: research

Mildly elevated serum bilirubin is associated with a lower risk of hearing loss in Chinese adults.
PMID: 33323811 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Xue F, Zhang H, Chen QY, Li CH, Wang SC, Xu LW, Yang L, Lian FZ Tags: Chin Med J (Engl) Source Type: research

Acute pancreatitis may be a pathogenic factor of fulminant type 1 diabetes mellitus.
PMID: 33323812 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Chen YN, Zhao MW, Cui J, Yao HB Tags: Chin Med J (Engl) Source Type: research

Effects of meteorological factors on daily outpatient visits for skin diseases: a time series study in a Chinese population.
PMID: 33323813 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Zhang W, Zhang YJ, Shen XP, Ning GC, Wei YJ, Zeng W, Yu DH, Lu HG Tags: Chin Med J (Engl) Source Type: research

A survey on pediatric anti-N-methyl-D-aspartate-receptor encephalitis treatment strategies in China.
PMID: 33323814 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Cao XS, Kessi M, Ji TY, Jiang YW, Yin F, Peng J Tags: Chin Med J (Engl) Source Type: research

Unusual co-occurrence of cold agglutinin disease in a bladder transitional cell carcinoma patient with unexplained anemia and cold-related symptoms.
PMID: 33323815 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Li S, Zhang L, Wang W Tags: Chin Med J (Engl) Source Type: research

Diagnostic indexes of a rapid immunoglobulin G/immunoglobulin M combined antibody test for severe acute respiratory syndrome coronavirus 2.
PMID: 33323816 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Liu Y, Liu YP, Diao B, Ding JY, Yuan MX, Ren FF, Wang Y, Huang QC Tags: Chin Med J (Engl) Source Type: research

Th17 cells are involved in mouse chronic obstructive pulmonary disease complicated with invasive pulmonary aspergillosis.
CONCLUSION: These findings indicate that Th17 cells might be involved in the pathogenesis of COPD combined with IPA, with IL-17 likely playing an antifungal role. PMID: 33323817 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Geng WR, He HY, Zhang Q, Tong ZH Tags: Chin Med J (Engl) Source Type: research

Effects of cisplatin in combination with hyperthermia on biological characteristics of retroperitoneal liposarcoma.
PMID: 33323818 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Miao CL, Hanif S, Zhang L, Chen XB, Huang M, Liu SB, Luo CH Tags: Chin Med J (Engl) Source Type: research

Chinese expert consensus on the diagnosis and treatment of severely and critically ill patients with coronavirus disease 2019.
PMID: 33323819 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Sun TW, Zhang XJ, Yu Z, Shang Y Tags: Chin Med J (Engl) Source Type: research

An update on the role of long non-coding RNAs in psoriasis.
Abstract Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational levels; however, the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored. This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendr...
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Song JK, Yin SY, Li W, Li XD, Luo Y, Luo Y, Xing M, Li B, Kuai L Tags: Chin Med J (Engl) Source Type: research

Real-world clinical experience of secukinumab in Chinese patients with psoriasis in real-world practice: a 36-week single-center study of 24 patients.
PMID: 33323821 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 14, 2020 Category: General Medicine Authors: Zhang J, Ji C, Cheng B, Ruan SF, Liu T, Huang JW Tags: Chin Med J (Engl) Source Type: research

Long-term results of extensive aortoiliac occlusive disease (EAIOD) treated by endovascular therapy and risk factors for loss of primary patency.
Abstract BACKGROUND: Although endovascular therapy has been widely used for focal aortoiliac occlusive disease (AIOD), its performance for extensive AIOD (EAIOD) is not fully evaluated. We aimed to demonstrate the long-term results of EAIOD treated by endovascular therapy and to identify the potential risk factors for the loss of primary patency. METHODS: Between January 2008 and June 2018, patients with a clinical diagnosis of the 2007 TransAtlantic Inter-Society Consensus II (TASC II) C and D AIOD lesions who underwent endovascular treatment in our institution were enrolled. Demographic, diagnosis, procedur...
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Jiang XL, Shi Y, Chen B, Jiang JH, Ma T, Lin CP, Guo DQ, Xu X, Dong ZH, Fu WG Tags: Chin Med J (Engl) Source Type: research

Cerebral infarction after drug-eluting bead bronchial arterial chemoembolization due to the mechanical force-mediated opening of an errant passage.
PMID: 33323823 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Luo W, Wei MG, Wei HL, Li YL Tags: Chin Med J (Engl) Source Type: research

Multifactorial role of HIV-Vpr in cell apoptosis revealed by a naturally truncated 54aa variant.
PMID: 33323824 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Du L, Wu CS, Sun J, Yu T, Lyu PP, Han SF, Qiu C, Meng ZF Tags: Chin Med J (Engl) Source Type: research

Application of serum Golgi protein-73 in the management of chronic liver disease.
PMID: 33323825 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Yao MJ, Wang LJ, Liu S, Lu FM Tags: Chin Med J (Engl) Source Type: research

Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation: a single-center analysis.
PMID: 33323826 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Chen SS, Sun Q, Cao L, Wu WZ, Xie Y, Qiao C, Li JY, Qian SX, Hong M Tags: Chin Med J (Engl) Source Type: research

Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy.
In this study, we aimed to explore the role of the GRB2 associated binding protein 1 (GAB1) in regulating VEC autophagy. METHODS: In vivo and in vitro studies were applied to determine the loss of adapt protein GAB1 in association with ASO progression. Histological GAB1 expression was measured in sclerotic vascular intima and normal vascular intima. Gain- and loss-of-function of GAB1 were applied in VEC to determine the effect and potential downstream signaling of GAB1. RESULTS: The autophagy repressor p62 was significantly downregulated in ASO intima as compared to that in healthy donor (0.80 vs. 0.20, t = 6.43, P 
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Ye M, Guo XJ, Kan KJ, Ni QH, Chen JQ, Wang H, Qian X, Xue GH, Deng HY, Zhang L Tags: Chin Med J (Engl) Source Type: research

R-CHOP resistance in diffuse large B-cell lymphoma: biological and molecular mechanisms.
Abstract Although the first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone regimen (R-CHOP) substantially improved outcomes for patients with diffuse large B-cell lymphoma (DLBCL), 40% of the patients suffered from relapsed/refractory disease and had poor survival outcomes. The detailed mechanism underlying R-CHOP resistance has not been well defined. For this review, we conducted a thorough search for literature and clinical trials involving DLBCL resistance. We discussed DLBCL biology, epigenetics, and aberrant signaling of the B-cell receptor (BCR), phosphatidylinositol 3-kinase ...
Source: Chinese Medical Journal - December 8, 2020 Category: General Medicine Authors: Wang L, Li LR Tags: Chin Med J (Engl) Source Type: research