Value of fasting plasma glucose to screen gestational diabetes mellitus before the 24th gestational week in women with different pre-pregnancy body mass index.
Abstract BACKGROUND: Gestational diabetes mellitus (GDM) is usually diagnosed between 24th and 28th gestational week using the 75-g oral glucose tolerance test (OGTT). It is difficult to predict GDM before 24th gestational week because fast plasma glucose (FPG) decreases as the gestational age increases. It is controversial that if FPG ≥5.1 mmol/L before 24th gestational week should be intervened or not. The aim of this study was to evaluate the value of FPG to screen GDM before 24th gestational week in women with different pre-pregnancy body mass index (BMI). METHODS: This was a multi-region retrospective...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Wei YM, Liu XY, Shou C, Liu XH, Meng WY, Wang ZL, Wang YF, Wang YQ, Cai ZY, Shang LX, Sun Y, Yang HX Tags: Chin Med J (Engl) Source Type: research

Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome.
This study aimed to understand the concept of dysbiosis among patients with Chinese diarrhea-predominant IBS (IBS-D), as a degree of variance between the gut microbiomes of IBS-D population and that of a healthy population. METHODS: The patients with IBS-D were recruited (assessed according to the Rome III criteria, by IBS symptom severity score) from the Outpatient Department of Gastroenterology of Peking University Third Hospital, and volunteers as healthy controls (HCs) were enrolled, during 2013. The 16S rRNA sequences were extracted from fecal samples. Ribosomal database project resources, basic local alignment s...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Wang Z, Xu CM, Liu YX, Wang XQ, Zhang L, Li M, Zhu SW, Xie ZJ, Wang PH, Duan LP, Zhu HQ Tags: Chin Med J (Engl) Source Type: research

Predicting asymptomatic coronary artery stenosis by aortic arch plaque in acute ischemic cerebrovascular disease: beyond the cervicocephalic atherosclerosis?
This study aimed to investigate whether aortic arch plaque (AAP), an early atherosclerotic manifestation of brain blood-supplying arteries, could be a predictor for ACAS ≥50% in AICVD. METHODS: In this cross-sectional study, atherosclerosis of the coronary and brain blood-supplying arteries was simultaneously evaluated using one-step computed tomography angiography (CTA) in AICVD patients without coronary artery disease history. The patients were divided into ACAS ≥50% and non-ACAS ≥50% groups according to whether CTA showed stenosis ≥50% in at least one coronary arterial segment. The AAP characteristics o...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Ma X, Kong Q, Wang C, Rajah G, Ding YC, Zhang YR, Du XY Tags: Chin Med J (Engl) Source Type: research

Relationship between fibrinogen levels and cardiovascular events in patients receiving percutaneous coronary intervention: a large single-center study.
Abstract BACKGROUND: It is currently unclear if fibrinogen is a risk factor for adverse events in patients receiving percutaneous coronary intervention (PCI) or merely serves as a marker of pre-existing comorbidities and other causal factors. We therefore investigated the association between fibrinogen levels and 2-year all-cause mortality, and compared the additional predictive value of adding fibrinogen to a basic model including traditional risk factors in patients receiving contemporary PCI. METHODS: A total of 6293 patients undergoing PCI with measured baseline fibrinogen levels were enrolled from Januar...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Jiang P, Gao Z, Zhao W, Song Y, Tang XF, Xu JJ, Wang HH, Jiang L, Chen J, Qiao SB, Yang YJ, Gao RL, Xu B, Yuan JQ Tags: Chin Med J (Engl) Source Type: research

Radiofrequency deep hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer.
This study aimed to investigate the curative effects and safety of hyperthermia combined with chemotherapy (HCT) for advanced patients with non-small cell lung cancer (NSCLC), especially those with malignant pleural effusion. METHODS: We retrospectively evaluated medical records of 93 patients with advanced NSCLC (stage IIIB-IV) from March 2011 to January 2014. The patients were divided into HCT and chemotherapy (CT) groups. The HCT group was treated with gemcitabine and cisplatin (GP) regimen combined with regional radiofrequency deep hyperthermia, while the CT group was treated with GP regimen only. Those with malig...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Yang WH, Xie J, Lai ZY, Yang MD, Zhang GH, Li Y, Mu JB, Xu J Tags: Chin Med J (Engl) Source Type: research

Development and validation of a preoperative nomogram for predicting positive surgical margins after laparoscopic radical prostatectomy.
CONCLUSION: A nomogram to predict positive surgical margins after LRP was developed and validated, which could help urologists plan surgical procedures. PMID: 30958434 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Tian XJ, Wang ZL, Li G, Cao SJ, Cui HR, Li ZH, Liu Z, Li BL, Ma LL, Zhuang SR, Xiao QY Tags: Chin Med J (Engl) Source Type: research

Peri-operative application of intra-aortic balloon pumping reduced in-hospital mortality of patients with coronary artery disease and left ventricular dysfunction.
This study aimed to analyze the early outcomes of peri-operative application of IABP in coronary artery bypass grafting (CABG) among patients with CAD and left ventricular dysfunction, and to provide a clinical basis for the peri-operative use of IABP. METHODS: A retrospective analysis of 612 patients who received CABG in the General Hospital of People's Liberation Army between May 1995 and June 2014. Patients were assigned to an IABP or non-IABP group according to their treatments. Logistic regression analysis was performed to investigate the influence of peri-operative IABP implantation on in-hospital mortality. Fur...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: He XY, Gao CQ Tags: Chin Med J (Engl) Source Type: research

Risk of bleeding in patients with continued dual antiplatelet therapy during orthopedic surgery.
CONCLUSIONS: Continued DAPT or single antiplatelet treatment during orthopedic surgery does not increase the total intraoperative and perioperative bleeding compared with switching from antiplatelet therapy to low-molecular-weight heparin. However, the discontinuation of antiplatelet therapy increases the risk of serious cardiac complications. PMID: 30958436 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Hu SB, Hai Y, Tang JF, Liu T, Liang BX, Xue BQ Tags: Chin Med J (Engl) Source Type: research

Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
Abstract BACKGROUND: Cervical cancer has the fourth highest incidence and mortality rate of all cancers in women worldwide; it seriously harms their physical and mental health. The aim of this study was to observe the roles and preliminary mechanism of Taurine (Tau)-induced apoptosis in cervical cancer cells. METHODS: Cells from the human cervical cancer cell line SiHa were transfected with the recombinant plasmid pEGFP-N1-MST1 (mammalian sterile 20-like kinase 1); then, the cell proliferation activity was analyzed by the MTT assay, cell apoptosis by flow cytometry, and the related protein levels by Western b...
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Li H, Ruan WJ, Liu LQ, Wan HF, Yang XH, Zhu WF, Yu LH, Zhang XL, Wan FS Tags: Chin Med J (Engl) Source Type: research

Application of virtual histological intravascular ultrasound in plaque composition assessment of saphenous vein graft diseases.
CONCLUSIONS: In degenerative SVG lesions, VH-IVUS found that plaque composition was associated with clinical features, future studies need to explore the relationship between VH-IVUS defined atherosclerotic plaque components and clinical outcomes in SVGD patients undergoing PCI, an innovative prediction tool of clinical outcomes can be created. PMID: 30958438 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Gao J, Wang YY, Liu Y Tags: Chin Med J (Engl) Source Type: research

Endothelial glycocalyx as a potential theriapeutic target in organ injuries.
CONCLUSIONS: Disturbance of the eGC usually occurs at early stages of various clinical pathophysiologies which can be partly prevented and reversed by protecting and restoring the eGC. The eGC seems to be a promising diagnostic biomarker and therapeutic target in clinical settings. PMID: 30958439 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Cao RN, Tang L, Xia ZY, Xia R Tags: Chin Med J (Engl) Source Type: research

Application of robot-assisted laparoscopic pelvic exenteration in treating gynecologic malignancies.
PMID: 30958440 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Yang QY, Tang JY Tags: Chin Med J (Engl) Source Type: research

Follow-up of percutaneous transcatheter closure of pulmonary arteriovenous fistulas.
PMID: 30958441 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Xi SB, Xie YM, Qian MY, Shi JJ, Li YF, Zhang ZW Tags: Chin Med J (Engl) Source Type: research

Correlation between carbohydrate antigen 199 and glycemic control in patients with type 2 diabetes mellitus.
PMID: 30958442 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Bao SQ, Li FB, Jiang X Tags: Chin Med J (Engl) Source Type: research

Management of bronchial rupture after blunt chest trauma in children.
PMID: 30958443 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Wu YH, Jiang SL, Zhou YH, Ji X, Li YG, Wu C Tags: Chin Med J (Engl) Source Type: research

Protection role of resveratrol against alcohol-induced heart defect in zebrafish embryos.
PMID: 30958444 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Wang F, Lin J, Jian J, Wang YH, Guo N, Li Q Tags: Chin Med J (Engl) Source Type: research

Tumor-induced osteomalacia with IgG4-related lymph node disease.
PMID: 30958445 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Zhang Y, Xu C, Yang Y Tags: Chin Med J (Engl) Source Type: research

Anti-N-methyl-D-aspartate receptor encephalitis in a 17-year-old female patient with 3 years of follow-up.
PMID: 30958446 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Lu JP, Song XK, Li HY, Wang GP Tags: Chin Med J (Engl) Source Type: research

Corrigendum: Association of pre-pregnancy body mass index and gestational weight gain with labor stage.
Authors: PMID: 30958447 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Tags: Chin Med J (Engl) Source Type: research

Bilateral medial medullary infarction with distal stenosis of hypoplastic vertebral artery.
PMID: 30958448 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Lu JP, Wu Y, Xiao F, Li HY, Tang QQ Tags: Chin Med J (Engl) Source Type: research

A rare case of salivary gland choristoma in the middle ear with pharyngeal hamartoma.
PMID: 30958449 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Su QY, Hao SJ, Wang L, Ye FL Tags: Chin Med J (Engl) Source Type: research

Functioning gonadotroph adenoma.
PMID: 30958450 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Zhao Y, Lian W, Xing B, Feng M, Ma WB Tags: Chin Med J (Engl) Source Type: research

Protective effect of supplementation with Lycium ruthenicum Murray extract from exhaustive exercise-induced cardiac injury in rats.
PMID: 30958451 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Hou CW, Chen IC, Shu FR, Feng CH, Hung CT Tags: Chin Med J (Engl) Source Type: research

Comparing the effects of different drugs on postoperative cognitive dysfunction in elderly patients.
PMID: 30958452 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 10, 2019 Category: General Medicine Authors: Shao LJ, Xue FS, Guo RJ, Zheng L Tags: Chin Med J (Engl) Source Type: research

Novel endoscopic findings as visualized by non-magnification endoscopy with linked color imaging are indicative of gastric intestinal metaplasia.
CONCLUSIONS: A positive PIM finding in a suspicious lesion on LCI would complement LCI diagnosis of possible IM because of the positive predictive value of PIM. PIM could be a novel endoscopic marker for IM. TRIAL REGISTRATION: ClinicalTrials.gov, No. NCT03092414; https://clinicaltrials.gov/ct2/show/NCT03092414?id=NCT03092414&rank=1. PMID: 30896610 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Min M, Dong TH, Liu Y, Bi YL, Ma CY Tags: Chin Med J (Engl) Source Type: research

Organogenesis: need of the current world.
PMID: 30896611 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Ahmad A, Aslam HMU, Afzal MS, Bhutta Z Tags: Chin Med J (Engl) Source Type: research

Recurrence of Helicobacter pylori infection: incidence and influential factors.
CONCLUSIONS: The 1-year and 3-year recurrence rates of H. pylori infection after eradication therapy are 1.75% and 4.61%. Low-income, poor hygiene condition of dining out place, and a combination of invasive diagnoses or treatments are independent risk factors of H. pylori recurrence. PMID: 30897591 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Xue Y, Zhou LY, Lu HP, Liu JZ Tags: Chin Med J (Engl) Source Type: research

Efficacy of weight adjusted bone mineral content in osteoporosis diagnosis in Chinese female population.
CONCLUSIONS: wBMC can reduce the missed diagnosis in patients with large body weight and reduce misdiagnosis in those with small body weight. Including children, wBMC may be feasible for osteoporosis diagnosis individuals at any age. PMID: 30897592 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Liu TT, Li XD, Wang WZ, Zhang JG, Yang DZ Tags: Chin Med J (Engl) Source Type: research

Prevalence of musculoskeletal symptoms among industrial employees in a modern industrial region in Beijing, China.
This study aimed to investigate the prevalence and risk factors of MSDs in a modern industrial region of Beijing. METHODS: A cross-sectional study included 1415 employees in six industrial companies was conducted between January 2018 and May 2018 in Fangshan district, Beijng, China. Nordic Musculoskeletal Questionnaire (NMQ) was used to collect the information about MSDs. Demographic factors, lifestyle factors, health and medical factors, and work-related factors were collected as independent variables. Descriptive statistics, the chi-squared (χ) test, and binary logistic regression analysis were used to analyze d...
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Wang T, Zhao YL, Hao LX, Jia JG Tags: Chin Med J (Engl) Source Type: research

Evolution of transmaxillary approach to tumors in pterygopalatine fossa and infratemporal fossa: anatomic simulation and clinical practice.
CONCLUSIONS: With the widespread use of neuroendoscopy, the modified endoscopic transnasal transmaxillary approach is feasible and effective for the resection of tumors located in PPF and ITF, which has significant advantages on less trauma and complications to the patients. PMID: 30897594 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Xue Z, Liu J, Bi ZY, Yi ZQ, Bao SD, Liu PN, Yang ZJ Tags: Chin Med J (Engl) Source Type: research

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies.
CONCLUSION: The mTOR pathway might be activated in myofibers with various metabolic defects, which might provide evidence for mTOR inhibition therapy in human IMMs. PMID: 30897595 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Lyu JW, Xu XB, Ji KQ, Zhang N, Sun Y, Zhao DD, Zhao YY, Yan CZ Tags: Chin Med J (Engl) Source Type: research

Heterotopic ossification after arthroscopy for hip impingement syndrome.
Abstract BACKGROUND: Heterotopic ossification (HO) is a known complication of hip arthroscopy. We investigated incidence of HO after hip arthroscopy and determined whether revision for HO improved outcome. METHODS: A retrospective study was conducted on 242 patients (140 men and 102 women, mean age: 36.2 ± 9.5 years) who underwent hip arthroscopy for femoroacetabular impingement (FAI) between January 2016 and January 2018. The average follow-up period was 22.88 ± 11.74 months (range: 11-34 months). Thirteen (5.37%) cases of HO (six men and seven women, five left hips and eight right hips...
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Gao GY, Zhang X, Dai LH, Huang HJ, Wu RQ, Ju XD, Mei Y, Niu XY, Wang JQ, Xu Y Tags: Chin Med J (Engl) Source Type: research

RNA-seq analysis of molecular heterogeneity peripheral blood mononuclear cells in systemic lupus erythematosus.
PMID: 30897597 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Xue K, Zheng YJ, Yu RX, Shen X, Cui Y Tags: Chin Med J (Engl) Source Type: research

Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea.
PMID: 30897598 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Fu JL, Wang T, Xiao XH Tags: Chin Med J (Engl) Source Type: research

A novel MYH7 mutation resulting in Laing distal myopathy in a Chinese family.
PMID: 30897599 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Liu XY, Zhang YS, Sun AP, Zhong YF, Zheng DF, Fan DS Tags: Chin Med J (Engl) Source Type: research

Efficacy and influencing factors of allogeneic hematopoietic stem cell transplantation in treatment of 71 children with leukemia.
PMID: 30897600 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Zhang BL, Zhou J, Lyu TX, Gui RR, Zu YL, Yu FK, Zhao HF, Li Z, Wang J, Zhang YL, Zhang WL, Fu YW, Wei XD, Fang BJ, Li YF, Zhou KS, Song YP Tags: Chin Med J (Engl) Source Type: research

Broadening the phenotype of m.5703G > A mutation in mitochondrial tRNAAsn gene from mitochondrial myopathy to myoclonic epilepsy with ragged red fibers syndrome.
Broadening the phenotype of m.5703G>A mutation in mitochondrial tRNAAsn gene from mitochondrial myopathy to myoclonic epilepsy with ragged red fibers syndrome. Chin Med J (Engl). 2019 Apr 05;132(7):865-867 Authors: Fu J, Ma MM, Pang M, Yang L, Li G, Song J, Zhang JW PMID: 30897601 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Fu J, Ma MM, Pang M, Yang L, Li G, Song J, Zhang JW Tags: Chin Med J (Engl) Source Type: research

Malassezia furfur promoting growth of Staphylococcus epidermidis by increasing pH when cultured in a lipid-free environment.
PMID: 30897602 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Han Y, Zhang YJ, Wang HX, Sun YZ, Yang Y, Li ZX, Qi RQ, Gao XH Tags: Chin Med J (Engl) Source Type: research

Evaluation of pulmonary regurgitation by using different cardiac magnetic resonance indices in children with repaired tetralogy of Fallot.
PMID: 30897603 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Yao Q, Shen QL, Hu XH, Qiao ZW, Huang GY Tags: Chin Med J (Engl) Source Type: research

Research progress of bariatric embolization for treatment of obesity.
PMID: 30897604 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 22, 2019 Category: General Medicine Authors: Zhong BY, Li PC, Ni CF Tags: Chin Med J (Engl) Source Type: research

Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria.
Abstract BACKGROUND: Ciprofloxacin is usually used in the treatment of lower respiratory tract infections (LRTIs). Recent studies abroad have shown ciprofloxacin is inadequately dosed and might lead to worse outcomes. The aim of this study was to perform pharmacokinetic and pharmacodynamic analyses of ciprofloxacin in elderly Chinese patients with severe LRTIs caused by Gram-negative bacteria. METHODS: From September 2012 to June 2014, as many as 33 patients were empirically administered beta-lactam and ciprofloxacin combination therapy. Patients were infused with 200 or 400 mg of ciprofloxacin every 12 h, wh...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Gai XY, Bo SN, Shen N, Zhou QT, Yin AY, Lu W Tags: Chin Med J (Engl) Source Type: research

Analysis of platelet parameters and activation markers in hematologic metastases of lung cancer.
PMID: 30855293 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Zhang SS, Zhang M, Yuan L, Zou ZQ Tags: Chin Med J (Engl) Source Type: research

Comparative outcomes of subcutaneous and transvenous cardioverter-defibrillators.
CONCLUSIONS: The efficacy of an S-ICD is comparable to that of T-ICD, especially in a dominantly HCM patient population. The S-ICD is associated with fewer major complications demanding reoperation. PMID: 30855343 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Liang JJ, Okamura H, Asirvatham R, Schneider A, Hodge DO, Yang M, Li XP, Dai MY, Tian Y, Zhang P, Cannon BC, Huang CX, Friedman PA, Cha YM Tags: Chin Med J (Engl) Source Type: research

A non-invasive diagnostic model of immunoglobulin A nephropathy and serological markers for evaluating disease severity.
Abstract BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common pathological type of glomerular disease. Kidney biopsy, the gold standard for IgAN diagnosis, has not been routinely applied in hospitals worldwide due to its invasion nature. Thus, we aim to establish a non-invasive diagnostic model and determine markers to evaluate disease severity by analyzing the serological parameters and pathological stages of patients with IgAN. METHODS: A total of 272 biopsy-diagnosed IgAN inpatients and 518 non-IgA nephropathy inpatients from the Department of Nephrology of Chinese People's Liberation Army Ge...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Han QX, Wang Y, Zhu HY, Zhang D, Gao J, Liu ZS, Cai GY, Chen XM Tags: Chin Med J (Engl) Source Type: research

Upper airway cough syndrome in 103 children.
This study aimed to determine the pathogenetic constituents and factors affecting UACS in children of different age groups, and to identify clinical clues for diagnosing UACS and a method for curative effect evaluation. METHODS: A total of 103 children with UACS whose chief complaint was chronic cough were studied from January to November 2013 at Children's Hospital, Capital Institute of Pediatrics. According to their age, children with UACS were divided into 3 groups: nursing children, pre-school children, and school-age children. We analyzed the differences in pathogenetic constituents and factors affecting UACS in ...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Gao F, Gu QL, Jiang ZD Tags: Chin Med J (Engl) Source Type: research

Matrine suppresses lipopolysaccharide-induced fibrosis in human peritoneal mesothelial cells by inhibiting the epithelial-mesenchymal transition.
Abstract BACKGROUND: Peritoneal fibrosis is the primary reason that patients with end-stage renal disease (ESRD) have to cease peritoneal dialysis. Peritonitis caused by Gram-negative bacteria such as Escherichia coli (E. coli) were on the rise. We had previously shown that matrine inhibited the formation of biofilm by E. coli. However, the role of matrine on the epithelial-mesenchymal transition (EMT) in peritoneal mesothelial cells under chronic inflammatory conditions is still unknown. METHODS: We cultured human peritoneal mesothelial cells (HPMCs) with lipopolysaccharide (LPS) to induce an environment tha...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Li YZ, Peng X, Ma YH, Li FJ, Liao YH Tags: Chin Med J (Engl) Source Type: research

Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin.
This study aimed to investigate the effect of mTOR signaling pathway in PE-like model treated with Pra. METHODS: Pregnant mice were randomly injected with L-NAME as PE-like model group or saline as control group respectively, from gestational 7th to 18th day. Giving Pra (L-NAME + Pra, Control + Pra, n = 8) or normal saline (NS; L-NAME + NS, Control + NS, n = 8) from gestational 8th to 18th day, the mice were sacrificed on day 18 and their liver and placental tissues were collected. Then the activation of mTOR and its substrates in the liver and placenta were detected. And the association betwee...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Huai J, Yang Z, Yi YH, Wang GJ Tags: Chin Med J (Engl) Source Type: research

Epithelial defect repair in the auricle and auditory meatus by grafting with cultured adipose-derived mesenchymal stem cell aggregate-extracellular matrix.
Abstract BACKGROUND: Several patients experience persistent otorrhea after a flawless surgical procedure because of insufficient epithelial healing. Several efforts, such as autologous tissue allograft and xenograft, have been made to halt otorrhea. However, a stable technology to induce temporal epithelial repair is yet to be established. Therefore, this study aims to investigate whether implantation of seeding adipose-derived mesenchymal stem cell (ADMSC) aggregates on extracellular matrix (ECM; herein, ADMSC aggregate-ECM) into damaged skin wound promotes skin regeneration. METHODS: ADMSC aggregate-ECM was...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Zhang WJ, Ming LG, Sun JJ Tags: Chin Med J (Engl) Source Type: research

Hyperbaric oxygen improves functional recovery of rats after spinal cord injury via activating stromal cell-derived factor-1/CXC chemokine receptor 4 axis and promoting brain-derived neurothrophic factor expression.
This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF). METHODS: An acute SCI rat model was established in Sprague-Dawley rats using the Allen method. Sixty rats were divided into four groups (n = 15 in each group): sham-operated, SCI, SCI treated with HBO (SCI + HBO), and SCI treated with both HBO and AMD3100 (an antagonist of CXCR4; SCI + HBO + AMD) groups...
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Meng XL, Hai Y, Zhang XN, Wang YS, Liu XH, Ma LL, Yue R, Xu G, Li Z Tags: Chin Med J (Engl) Source Type: research

Perioperative acupuncture medicine: a novel concept instead of acupuncture anesthesia.
CONCLUSIONS: The novel concept "perioperative acupuncture medicine" is to focus on the optimal treatment in the perioperative period of surgical patients. The review reveals the important role of acupuncture in enhancing rapid recovery of patients during the perioperative period. PMID: 30855351 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 12, 2019 Category: General Medicine Authors: Yuan W, Wang Q Tags: Chin Med J (Engl) Source Type: research