Comprehensive Genomic Characterization in Ovarian Low-Grade and chemosensitive and chemoresistant High-Grade Serous Carcinomas
CONCLUSIONS: These results suggest that very low TMB and MYC, CCNE1 and AKT2 gains in SOC patients may be biomarkers related to platinum treatment efficacy. Thorough genomic characterization of SOCs prior to treatment might lead to more specific platinum-based chemotherapy therapy strategies.PMID:38697030 | DOI:10.1159/000538948 (Source: Oncology)
Source: Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Carolina Jaliffa Uwe Rogel Indrani Sen Gad Singer Source Type: research
Quality of care measurement for patients with ovarian cancer in Japan
CONCLUSIONS: The quality of ovarian cancer care should be continuously assessed to encourage the use of best practices. These indicators may be a useful tool for this purpose.PMID:38697202 | DOI:10.1111/jog.15961 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Tamaki Kakuwa Tomone Watanabe Mariko Niino Akira Kawata Toyomi Satoh Noriomi Matsumura Yoshihito Yokoyama Kei Kawana Yasuyuki Hirashima Satoru Kyo Masanori Yasuda Kenichi Harano Hiroko Machida Hideki Tokunaga Masanori Kaneuchi Tsutomu Tabata Yoichi Kobaya Source Type: research
The burden of disease due to dietary exposure to acrylamide in Italy: a risk assessment-based approach
Food Chem Toxicol. 2024 Apr 30:114699. doi: 10.1016/j.fct.2024.114699. Online ahead of print.ABSTRACTThe aim of this study was to assess Italian consumers' risk of cancer and burden of disease due to dietary exposure to acrylamide. Our model considered six age groups such as infants, toddlers, other children, adolescents, adults, and the elderly, and the consumption of 31 food items. Using a risk-assessment-based approach, we first characterized the risk of neoplastic effects using the margin of exposure method. Then the risk of kidney, endometrial, breast, ovarian cancer, and total cancer was estimated using adjusted canc...
Source: Food and Chemical Toxicology - May 2, 2024 Category: Food Science Authors: Octavian Augustin Mihalache Chiara Dall'Asta Source Type: research
Concerns about fertility, social appearance, and relationships in young adults with polycystic ovary syndrome
CONCLUSION: Young adults have common concerns about the potential negative impacts of PCOS on fertility, social appearance, and relationships. Health professionals should be aware of their counselling needs about the possible physical and psycho-social effects of PCOS and provide continuous care and support.PMID:38695338 | DOI:10.1080/02646838.2024.2348645 (Source: Journal of Reproductive and Infant Psychology)
Source: Journal of Reproductive and Infant Psychology - May 2, 2024 Category: Psychiatry & Psychology Authors: Esra Sari İlkay Gungor Satilmis Source Type: research
Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates: 2004-2009 Compared With 2014-2020
CONCLUSION: This analysis provides insights into the changing landscape of ART treatments in the United States over the past two decades. The observed shifts in demographics, clinical practices, and technology highlight the dynamic nature of an evolving field of reproductive medicine. These findings may offer insight for clinicians to consider in counseling patients and to inform future research endeavors in the field of ART.PMID:38696814 | DOI:10.1097/AOG.0000000000005598 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - May 2, 2024 Category: OBGYN Authors: Sarah F Wang David B Seifer Source Type: research
Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by Radiofrequency Electromagnetic Radiation from Cell Phones via Upregulation of the CREM Signaling Pathway
CONCLUSION: The findings of this study indicate that P. ginseng extract shields against pituitary-ovarian impairment linked to RF-EMR exposure from cell phones by boosting antioxidant capacity and promoting the CREM-dependent pathway.PMID:38693729 | DOI:10.2174/0115701638279386240425050818 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - May 2, 2024 Category: Drugs & Pharmacology Authors: Oyetunji A Oyewopo Olabimpe C Badejogbin Isaac O Ajadi Linus A Enye Mary B Ajadi Ikponmwosa V Ebuwa Olutunmise V Owolabi Stephanie E Areloegbe Kehinde S Olaniyi Source Type: research
Predictors of olaparib discontinuation owing to adverse drug events in patients with ovarian, peritoneal, or fallopian tube cancer: a retrospective observational study
J Chemother. 2024 May 2:1-7. doi: 10.1080/1120009X.2024.2345025. Online ahead of print.ABSTRACTWe investigated predictors of olaparib discontinuation owing to adverse effects. Patients with ovarian, peritoneal, or fallopian tube cancers treated with olaparib at Osaka Medical and Pharmaceutical University Hospital between April 2018 and September 2022 were included in this study. The exclusion criteria were as follows: discontinuation of treatment due to disease progression, use of anaemia medications, and use of cytochrome P450 (CYP3A4) inhibitors. The follow-up period was 90 d. Of the 46 eligible patients, 21 patients dis...
Source: Journal of Chemotherapy - May 2, 2024 Category: Cancer & Oncology Authors: Noriaki Kataoka Takeo Hata Kouichi Hosomi Atsushi Hirata Satoe Fujiwara Emi Goto Masami Nishihara Masahide Ohmichi Masashi Neo Source Type: research
GSE235099 Transcriptomes of high-grade serous ovarian cancer cell lines cultured in monolayer and in spheroids.
Contributors : Joash D Joy ; Eleni Maniati ; Frances R BalkwillSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHGSOC cancer cell lines OvCAR3 and G164 were cultured in monolayer and spheroids and subjected to RNA-sequencing. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Reply to the Letter to the Editor on “Prolactin is a Key Factor for
Nonalcoholic Fatty Liver Disease in Obese Children”
Horm Metab Res DOI: 10.1055/a-2301-3272Dear Editor,The authors thank the writers 1 of the
letter for reviewing and assessing our article 2, “Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children”. Overall, we agree that possible selection bias must be considered.
However, in clinical studies, we found that hyperprolactinemia is mainly caused by
pathological and idiopathic hyperprolactinemia. The former includes hypothalamic
pituitary lesions (pituitary prolactinoma and empty sella syndrome, etc.), systemic
diseases (hypothyroidism, e...
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Zhang, Jianwei Tags: Letter to the Editor Source Type: research
Fertility Preservation in Patients with Breast Cancer
AbstractPurpose of ReviewMany breast cancer treatments are gonadotoxic, which can result in infertility in survivors. Patients should be counseled on the impact of cancer treatment on future fertility and their options regarding fertility preservation. The main purpose of this narrative review is to discuss the implications of breast cancer treatment on future fertility and review various strategies for fertility preservation and their safety in this population.Recent FindingsThere is no demonstrated effect of ovarian stimulation, GnRH agonist therapy, or ovarian tissue cryopreservation/transplantation on breast cancer out...
Source: Current Breast Cancer Reports - May 2, 2024 Category: Cancer & Oncology Source Type: research
A cuproptosis-related signature predicts prognosis and indicates cross-talk with immunocyte in ovarian cancer
ConclusionThis study constructed a new cuproptosis-related gene signature that has a good prognostic capacity in assessing the outcome of OC patients. This study enhances our understanding of cuproptosis associated with ovarian cancer aggressiveness, cross-talk with immunocytes, and serves as a novel chemotherapy strategy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 2, 2024 Category: Cancer & Oncology Source Type: research
Bioinformatic analysis of the role of immune checkpoint genes and immune infiltration in the pathogenesis and development of premature ovarian insufficiency
ConclusionBioinformatic analysis identified seven potential ICRDEGs associated with POI, among which the immune checkpoint moleculesCD200 and neurociliary protein-1 may be involved in the pathogenesis of POI. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 2, 2024 Category: Reproduction Medicine Source Type: research
Stringent criteria needed for germline genome editing of human IVF embryos
AbstractGermline genome editing of IVF embryos is controversial because it is not directly health or lifesaving but is intended to prevent genetic diseases in yet-unborn future offspring. The following criteria are thus proposed for future clinical trials: (i) Due to medical risks, there should be cautious and judicious application while avoiding any non-essential usage, with rigorous patient counseling. (ii) Genome editing should only be performed on the entire batch of IVF embryos without initial PGT screening if all of them are expected to be affected by genetic disease. (iii) When there is a fair chance that some IVF e...
Source: Journal of Assisted Reproduction and Genetics - May 2, 2024 Category: Reproduction Medicine Source Type: research
Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells
Cancer Gene Therapy, Published online: 02 May 2024; doi:10.1038/s41417-024-00777-5Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - May 2, 2024 Category: Cancer & Oncology Authors: I. A. McNeish T. Tenev S. Bell M. Marani G. Vassaux N. Lemoine Source Type: research
NDC80 Kinetochore Complex Serves as a Potential Prognostic Predictor and Correlates with Immune Infiltrates in Epithelial Ovarian Cancer Patients
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 1, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
