The Impact of Information About COVID-19 on the Endocrine Stress System and Cognitive Distortions
Horm Metab Res DOI: 10.1055/a-1997-0550The coronavirus disease 2019 (COVID-19) pandemic is one of the major health concerns worldwide affecting not only human physical health but also contributing to the development of many mental disorders including impairment of the cognitive function. It is highly conceivable that elevation of the stress hormones, i.e., glucocorticoids and catecholamines, due to the infection, as well as the presence of psychosocial stressors, such as COVID-19 information, play a critical role in the development of these disorders. In...
Source: Hormone and Metabolic Research - January 20, 2023 Category: Endocrinology Authors: Lecl ère, Mariel Hysenaj, Arben Meha, Rina Tahirbegolli, Bernard Schwarz, Peter Steenblock, Charlotte Prekazi, Lulejete Isufi, Albane Shemsedini, Nevzat Tags: Review Source Type: research

Transcription Factor ELK3 Promotes Stemness and Oxaliplatin Resistance of Glioma Cells by Regulating RNASEH2A
This study attempted to investigate how ELK3 impacts the oxaliplatin resistance of glioma cells and its molecular mechanism. Bioinformatics analysis was employed to screen mRNAs with differential expression in glioma cells and predict the possible regulator downstream. We used qRT-PCR to detect the expression of ELK3 and RNASEH2A. Dual-luciferase and ChIP assays were adopted to reassure the regulatory relationship between the two. We also evaluated cell viability and sphere formation efficiency through CCK-8 and sphere formation assay and calculated the ...
Source: Hormone and Metabolic Research - January 13, 2023 Category: Endocrinology Authors: Mei, Yimin Chen, Duoning He, Shike Ye, Jinping Luo, Ming Wu, Qiangjun Huang, Yuan Tags: Original Article: Endocrine Research Source Type: research

MiR-99a-5p Inhibits the Proliferation and Migration of Human Retinal Microvascular Endothelial Cells by Targeting NOX4
In conclusion, MiR-99a-5p protected hRMECs against HG damage, and the miR-99a-5p might be a novel target for diagnosis of DR. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 11, 2023 Category: Endocrinology Authors: Yu, Haizhen Zhang, Xu Wang, Xuyang Chen, Wangling Lao, Wei Chen, Yunxin Tags: Original Article: Endocrine Research Source Type: research

Aprotinin does not Impair Vascular Function in Patients Undergoing Coronary Artery Bypass Graft Surgery
In conclusion, intraoperative and ex vivo application of aprotinin does not impair the endothelial function in human internal mammary arteries and experimental models. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 4, 2023 Category: Endocrinology Authors: Tolkmitt, Josephine Brendel, Heike Zatschler, Birgit Brose, Stefan Brunssen, Coy Kopaliani, Irakli Deussen, Andreas Matschke, Klaus Morawietz, Henning Tags: Original Article: Endocrine Research Source Type: research

Repurposing of Drugs for Cardiometabolic Disorders: An Out and Out Cumulation
Horm Metab Res 2023; 55: 7-24 DOI: 10.1055/a-1971-6965Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosclerosis such as insulin resistance (IR) or diabetes mellitus (DM), systemic hypertension, central obesity, and dyslipidemia. Cardiometabolic diseases (CMDs) continue to be the leading cause of mortality in both developed and developing nations, accounting for over 32% of all fatalities globally each year. Furthermore, dyslipidemia, angina, arrhythmia, heart failure, myocardial infarction (MI), and diabetes mellitus ...
Source: Hormone and Metabolic Research - January 4, 2023 Category: Endocrinology Authors: Wasim, Rufaida Ansari, Tarique Mahmood Siddiqui, Mohammed Haris Ahsan, Farogh Shamim, Arshiya Singh, Aditya Shariq, Mohammad Anwar, Aamir Siddiqui, Aquib Rehanullah Parveen, Saba Tags: Review Source Type: research

Thanks to the Reviewers
Horm Metab Res 2023; 55: 5-6 DOI: 10.1055/a-1977-0589 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 4, 2023 Category: Endocrinology Tags: Editorial Source Type: research

Dapagliflozin Presented Nonalcoholic Fatty Liver Through Metabolite Extraction and AMPK/NLRP3 Signaling Pathway
Horm Metab Res DOI: 10.1055/a-1970-3388In recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has been increasing year by year. The experiments conducted on rat elucidated the effect and underlying mechanism of dapagliflozin in NAFLD. Sprague Dawley rats were fed with HFD (Fat accounts for 52%, carbohydrate 34% and protein 14%) for 12 weeks as NAFLD model. Dapagliflozin presented NAFLD in rat model. Dapagliflozin reduced oxidative stress and inflammation in rat model of NAFLD. Dapagliflozin reduced oxidative stress and inflammation in ...
Source: Hormone and Metabolic Research - December 9, 2022 Category: Endocrinology Authors: Lin, Deng Song, Yuling Tags: Original Article: Endocrine Research Source Type: research

The Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Study
In conclusion, this study showed an association between pre-existing hyperthyroidism with higher COVID-19 mortality. A potential trend towards increased mortality was also observed for hypothyroidism. The risk was more pronounced in patients with hyperthyroidism. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 9, 2022 Category: Endocrinology Authors: Sahin, Mustafa Demirci, Ibrahim Haymana, Cem Tasci, Ilker Emral, R ıfat Cakal, Erman unluturk, Ugur Satman, Ilhan Demir, Tevfik Ata, Naim Ertugrul, Derun Atmaca, Aysegul Salman, Serpil Sahin, Ibrahim Dagdelen, Selcuk Celik, Osman Caglayan, Murat Sonmez, Tags: Original Article: Endocrine Care Source Type: research

Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis
This article aims to explore associated immune indicators of autoimmune thyroid disease (AITD) through a meta-analysis of published case-control studies on newly diagnosed AITD patients, intending to provide some suggestions for research on the mechanisms of AITD. Six electronic databases were searched for case-control studies on newly diagnosed AITD patients from inception to August 15, 2022. A random-effects model was used to calculate the standardized mean difference (SMD), odds ratio (OR), and 95% confidence interval (95% CI). A total of 26 articles ...
Source: Hormone and Metabolic Research - December 9, 2022 Category: Endocrinology Authors: Chen, Aizhi Huang, Liang Zhang, Liqin Tags: Original Article: Endocrine Care Source Type: research

Predictive Value of Inflammatory Cytokines in Early Pregnancy for Liver Dysfunction in Pregnant Women with Hepatitis B
Horm Metab Res DOI: 10.1055/a-1973-7255The purpose of this study is to explore the predictive value of cytokine levels in the first trimester of pregnancy on abnormal liver function of pregnant women with hepatitis B in the third trimester of pregnancy. A total of 111 pregnant women with HBV infection at 12 weeks gestation participated in the study. The levels of IL-6, IL-8, TNF-α in peripheral blood of the patients and liver function indexes were detected. Subsequently, the pregnant women were followed up, and the liver function was detected at 36 weeks of gesta...
Source: Hormone and Metabolic Research - November 29, 2022 Category: Endocrinology Authors: Wang, Wei Jia, Hongyan Wang, Yue Sun, Weize Yang, Can Tags: Original Article: Endocrine Care Source Type: research

The Influence of Levothyroxine on Body Composition and Physical Performance in Subclinical Hypothyroidism
This study investigates how far the intake of L-T4 influences body composition, energy expenditure, respiratory quotient as well as strength, endurance and mobility in premenopausal women who suffer from subclinical hypothyroidism. Twenty-five women (27.36±5.77 years) with subclinical hypothyroidism were included in the study. The intake of levothyroxine was assumed. Subjects were examined immediately after study inclusion, after two months of levothyroxine use, and after TSH was fully adjusted to the reference range. In all measurements TSH, ...
Source: Hormone and Metabolic Research - November 29, 2022 Category: Endocrinology Authors: Hanke, Lars Poeten, Pascal Spanke, Leroy Britz, Stephanie Diel, Patrick Tags: Original Article: Endocrine Care Source Type: research

BRAFV600E and BRAF-WT Specific Antitumor Immunity in Papillary Thyroid Cancer
In conclusion, we clearly demonstrated a BRAF-specific tumor immunity in PTC-patients which is, however, independent of a BRAFV600E status of the PTC patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 25, 2022 Category: Endocrinology Authors: Ehlers, Margret Schmidt, Mathias Mattes-Gyorgy, Katalin Antke, Christina Enczmann, Juergen Schlensog, Martin Japp, Anna Haase, Matthias Allelein, Stephanie Dringenberg, Till Giesel, Frederik Esposito, Irene Schott, Matthias Tags: Original Article: Endocrine Research Source Type: research

Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7
Horm Metab Res DOI: 10.1055/a-1961-6281KLF11 regulates insulin gene expression through binding to the insulin promoter and has been reported as a causative gene for maturity-onset diabetes of the young 7 (MODY7). Here, we report a novel KLF11 variant associated with a three-generation family with early childhood-onset diabetes and explore its clinical and functional characteristics. The three-generational pedigree contains five patients affected by diabetes. The pathogenic variant identified by whole-exome sequencing was further confirmed by Sanger sequencing and ...
Source: Hormone and Metabolic Research - November 24, 2022 Category: Endocrinology Authors: Guan, Gaopeng Qin, Tiantian Zhao, Li-ling Jin, Ping Tags: Original Article: Endocrine Research Source Type: research

Androgens ’ Role in Severity and Mortality Rates of COVID-19
Horm Metab Res DOI: 10.1055/a-1954-5605By the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. This review aimed to assess the role of androgens in COVID-19 severity and mortality. Androgens increase expressions of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2), which both facilita...
Source: Hormone and Metabolic Research - November 21, 2022 Category: Endocrinology Authors: Ataei, Ali Derakhshan, Mohammad Moein Razmjooie, Mohadese Zare, Fateme Amiresmaeili, Habibe Salehi, Negin Namakkoobi, Negar Mirhosseini, Hamid Karim, Bardia Iravani, Sima Tags: Review Source Type: research

Circulating Growth Differentiation Factor 15 and Preeclampsia: A Meta-Analysis
In conclusion, a higher circulating GDF-15 is observed in women with preeclampsia even before the diagnosis of the disease. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 21, 2022 Category: Endocrinology Authors: Wang, Lihong Yang, Qiuli Tags: Original Article: Endocrine Care Source Type: research