COVID-19, Diabetes, and Associated Health Outcomes in China: Results from a Nationwide Survey of 10 545 Adults
This study examined the associations between diabetes and self-reported/familial COVID-19 infection and investigated health-related outcomes among those with diabetes during China’s nationwide quarantine. The 2020 China COVID-19 Survey was administered anonymously via social media (WeChat). It was completed by 10 545 adults in all of mainland China’s 31 provinces. The survey consisted of 74 items covering sociodemographic characteristics, preventive measures for COVID-19, lifestyle behaviors, and health-related outcomes during the period of quarantine. Regression models e...
Source: Hormone and Metabolic Research - May 7, 2021 Category: Endocrinology Authors: Shi, Zumin Yan, Alice Zimmet, Paul Sun, Xiaoming Cristina do Vale Moreira, Nayla Cheskin, Lawrence J. Wang, Liming Qu, Weidong Yan, Hong Hussain, Akhtar Wang, Youfa Tags: Endocrine Care Source Type: research

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis
Horm Metab Res 2021; 53: 293-300 DOI: 10.1055/a-1475-4444Irisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes’ Library, China National Knowledge Infrastructure, and W...
Source: Hormone and Metabolic Research - May 7, 2021 Category: Endocrinology Authors: Wang, Rui Liu, Hongyan Tags: Review Source Type: research

Advanced Adrenocortical Carcinoma: Current Perspectives on Medical Treatment
This article provides a short summary of last years’ findings targeting outcomes, limitations, and adverse effects of these new therapeutic approaches. The results of recent trials and case series pointed pembrolizumab as the most promising drug among these new therapies. It is the most often used ICI and the one presenting the best results with less related adverse effects when in comparison to the standard treatment with mitotane. Hereafter, the identification of specific molecular biomarkers or immune profiles associated with ICI or mTKI good response will facilitate the sel...
Source: Hormone and Metabolic Research - May 7, 2021 Category: Endocrinology Authors: Ara újo, Alexandra Novais Bugalho, Maria Jo ão Tags: Review Source Type: research

Outcomes of Patients with Macroprolactinoma Desiring Pregnancy: Follow-Up to 23 Years from a Single Center
Horm Metab Res DOI: 10.1055/a-1468-4608Macroprolactinomas are rarely seen in women, and pregnancy is a risk factor for tumor growth. More studies are needed to determine appropriate management for macroprolactinoma and pregnancy. The aim of our study is to evaluate effects of treatment with dopamine agonists on macroadenoma before and during pregnancy, safety of dopamine agonists on fetus, post-pregnancy prognosis and long-term results. This is a single center retrospective study. Thirty-four pregnancies occurred in 21 patients under medical therapy. Prolactin levels, treatment results, tumor diameter changes, maternal-fet...
Source: Hormone and Metabolic Research - April 26, 2021 Category: Endocrinology Authors: Tanrikulu, Seher Yarman, Sema Tags: Endocrine Care Source Type: research

Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach
Horm Metab Res DOI: 10.1055/a-1440-0278The adrenal gland is important for many physiological and pathophysiological processes, but studies are often restricted by limited availability of sample material. Improved methods for sample preparation are needed to facilitate analyses of multiple classes of adrenal metabolites and macromolecules in a single sample. A procedure was developed for preparation of chromaffin cells, mouse adrenals, and human chromaffin tumors that allows for multi-omics analyses of different metabolites and preservation of native proteins. To evaluate the new procedure...
Source: Hormone and Metabolic Research - April 26, 2021 Category: Endocrinology Authors: Bechmann, Nicole Watts, Deepika Steenblock, Charlotte Wallace, Paal William Sch ürmann, Annette Bornstein, Stefan R. Wielockx, Ben Eisenhofer, Graeme Peitzsch, Mirko Tags: Endocrine Care Source Type: research

Distinct Prognostic Factors in Sporadic and Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors
Horm Metab Res DOI: 10.1055/a-1464-1276Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is the leading cause of death. Our aim was to compare the mortality risk in sporadic and MEN1-related PNETs and identify high-risk populations. A retrospective Surveillance, Epidemiology, and End Results database analysis of patients with PNET was used. Patients with MEN1 were defined by syn/metachronous pituitary adenoma. Clinical data were retrieved, and all-cause mortality (AC...
Source: Hormone and Metabolic Research - April 20, 2021 Category: Endocrinology Authors: Kfir, Sapir Kon Halperin, Reut Percik, Ruth Uri, Inbal Halpern, Naama Shlomai, Gadi Laish, Ido Tirosh, Amir Tirosh, Amit Tags: Endocrine Care Source Type: research

Differential Effects of Various Androgens on Polycystic Ovary Syndrome
Horm Metab Res DOI: 10.1055/a-1422-3243The hyperandrogenism in polycystic ovary syndrome (PCOS) is associated with the risk for the future development of the cardiovascular disease. The objective of the study is to verify whether different androgens have the same harmful effect. This cross-sectional study enrolled 823 women with PCOS: 627 (76.2%) with biochemical hyperandrogenism and 196 (23.8%) with normal androgen levels. The role of individual androgen was evaluated using univariate and multivariate logistic regression. In normoandrogenemic PCOS (NA-PCOS), free androgen index (FAI) predicted significant abnormality in v...
Source: Hormone and Metabolic Research - April 20, 2021 Category: Endocrinology Authors: de Medeiros, Sebasti ão Freitas Barbosa, Bruna Barcelo de Medeiros, Ana Karine Lin Winck Yamamoto de Medeiros, Matheus Ant ônio Souto Yamamoto, M árcia Marly Winck Tags: Endocrine Care Source Type: research

Correction: Cumulative Effects of Thyroid Hormones Over 10 Years and Risk of General and Abdominal Obesity
Horm Metab Res DOI: 10.1055/a-1469-9144 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 19, 2021 Category: Endocrinology Authors: Mehran, Ladan Amouzegar, Atieh Gharibzadeh, Safoora Abdi, Hengameh Mansournia, Mohammad Ali Tohidi, Maryam Azizi, Fereidoun Tags: Erratum Source Type: research

Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism
Horm Metab Res DOI: 10.1055/a-1409-5310The contribution of PAX8 genetic variants to congenital hypothyroidism (CH) is not well understood. We aimed to study the genetic variability of exons 3 and 5 of PAX8 gene among a cohort of children with congenital hypothyroidism in correspondence to their clinical aspect. Blood samples were collected from 117 children (63 girls and 54 boys) with CH and enrolled as cases (Group I). All cases underwent biochemical confirmation with low FT4 and high TSH levels and thyroid gland imaging, along with equal number of matched apparently healthy individuals who served as controls (Group II). ...
Source: Hormone and Metabolic Research - April 16, 2021 Category: Endocrinology Authors: El-Ella, Sohier S. Abou Khattab, Essam Shawky A.E.H. Beddah, Rehab K. Barseem, Naglaa Fathy Tags: Endocrine Care Source Type: research

Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data
This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidenc...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Ma, Chaochao Li, Xiaoqi Liu, Lixin Cheng, Xinqi Xue, Fang Wu, Jie Xia, Liangyu Yin, Yicong Wang, Danchen Zou, Yutong Qiu, Ling Liu, Juntao Tags: Endocrine Care Source Type: research

Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study
Horm Metab Res 2021; 53: 245-256 DOI: 10.1055/a-1402-0183Multiple Endocrine Neoplasia type-1 (MEN1) is an autosomal dominant disorder with a combined occurrence of tumours of parathyroid glands, pancreatic islets, and anterior pituitary. About 90% of these patients carry mutations in the MEN1 gene, though the spectrum is not well defined in India. Forty clinically suspected cases of MEN1 were enrolled prospectively over six years; 32 patients (23 index-cases and nine affected relatives) with≥2 classical endocrine tumours of MEN1 were considered definite, and eight were categorised as ‘MEN1-like’. Details of ...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Shyamasunder, Asha Hesarghatta Pai, Rekha Ramamoorthy, Hemalatha Sakhti, Dhananjayan Manipadam, Marie Therese Kapoor, Nitin Paul, Thomas Vizhalil Jebasingh, Felix Thomas, Nihal Abraham, Deepak Thomas Paul, Mazhuvanchary Jacob Chacko, Ari George Prabhu, Kr Tags: Endocrine Care Source Type: research

Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy
Horm Metab Res 2021; 53: 211-218 DOI: 10.1055/a-1386-4512Thyroid-associated ophthalmopathy (TAO) is a potentially sight-threatening ocular disease. About 3–5% of patients with TAO have severe disease with intense pain, inflammation, and sight-threatening corneal ulceration or compressive optic neuropathy. The current treatments of TAO are often suboptimal, mainly because the existing therapies do not target the pathogenesis of the disease. TAO mechanism is unclear. Ocular fibrocytes express relatively high levels of the functional TSH receptor (TSHR), and many indirect evidences support its participation. Over expres...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Ding, Yizhi Yang, Shaoqin Gao, Hua Tags: Review Source Type: research

Cumulative Effects of Thyroid Hormones Over 10 Years and Risk of General and Abdominal Obesity
Horm Metab Res DOI: 10.1055/a-1393-5864We aimed to assess if changes in thyrotropin (TSH) and free thyroxine (FT4) over 10 years of follow-up would be associated with changes in body mass index (BMI) and waist circumference (WC) or risk of obesity. We enrolled 2317 out of 4179 participants in Tehran Thyroid Study with serum TSH between 0.1–10 mU/l and without history of thyroid medication or surgery. Serum concentrations of FT4 and TSH were measured at baseline and three follow-ups (1999–2011). To account for within-subject correlation, the generalized estimating equation was used to assess the associati...
Source: Hormone and Metabolic Research - March 23, 2021 Category: Endocrinology Authors: Mehran, Ladan Amouzegar, Atieh Gharibzadeh, Safoora Abdi, Hengameh Mansournia, Mohammadali Tohidi, Maryam Azizi, Fereidoun Tags: Endocrine Care Source Type: research

Association Between Metabolic Syndrome and All-Cause Mortality in Patients with Acute Coronary Syndrome: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1381-8245The association between metabolic syndrome (MetS) and survival outcome after acute coronary syndrome (ACS) remains controversial. This meta-analysis sought to examine the association of MetS with all-cause mortality among patients with ACS. Two authors independently searched PubMed and Embase databases (from their inception to June 27, 2020) for studies that examined the association of MetS with all-cause mortality among patients with ACS. Outcome measures were in-hospital mortality and all-cause mortality during the follow-up. A total of 10 studies involving 49 896 ACS patients were ...
Source: Hormone and Metabolic Research - March 10, 2021 Category: Endocrinology Authors: Yang, Yong Shen, Haili Jin, Zhigeng Ma, Dongxing Zhao, Qing Zhang, Xuyi Tags: Original Articles Source Type: research

Polycystic Ovary Syndrome and Fibrocystic Breast Disease: An Updated Review
In conclusion, there is no clear association between benign breast disease and PCOS. Further studies on a large population with prospectively collected data using updated PCOS criteria are necessary. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 8, 2021 Category: Endocrinology Authors: Kunicki, Micha ł Smolarczyk, Roman Tags: Review Source Type: research

Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives
Horm Metab Res 2021; 53: 149-160 DOI: 10.1055/a-1380-4154Notwithstanding regulatory approval of lenvatinib and sorafenib to treat radioiodine-refractory differentiated thyroid carcinoma (RAI-R DTC), important questions and controversies persist regarding this use of these tyrosine kinase inhibitors (TKIs). RAI-R DTC experts from German tertiary referral centers convened to identify and explore such issues; this paper summarizes their discussions. One challenge is determining when to start TKI therapy. Decision-making should be shared between patients and multidisciplinary caregivers, and should consider tumor size/burden, ...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Verburg, Frederik A. Amthauer, Holger Binse, Ina Brink, Ingo Buck, Andreas Darr, Andreas Dierks, Christine Koch, Christine K önig, Ute Kreissl, Michael C. Luster, Markus Reuter, Christoph Scheidhauer, Klemens Willenberg, Holger Sven Zielke, Andreas Schot Tags: Review Source Type: research

The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease
Horm Metab Res 2021; 53: 204-206 DOI: 10.1055/a-1377-6583Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter our cells causing damage and disease. Our international research training programme funded by the German Research Foundation has a clear mission to train the best students wherever they may come from to learn to tackle the enormous challenges of diabetes and its complications for our society. A modern t...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Bornstein, S. R. Guan, K. Brun ßen, C. Mueller, G. Kamvissi-Lorenz, V. Lechler, R. Trembath, R. Mayr, M. Poston, L. Sancho, R. Ahmed, S. Alfar, E. Aljani, B. Alves, T. C. Amiel, S. Andoniadou, C. L. Bandral, M. Belavgeni, A. Berger, I. Birkenfeld, A. Bon Tags: Commentary Source Type: research

Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives
Horm Metab Res 2021; 53: 149-160 DOI: 10.1055/a-1380-4154Notwithstanding regulatory approval of lenvatinib and sorafenib to treat radioiodine-refractory differentiated thyroid carcinoma (RAI-R DTC), important questions and controversies persist regarding this use of these tyrosine kinase inhibitors (TKIs). RAI-R DTC experts from German tertiary referral centers convened to identify and explore such issues; this paper summarizes their discussions. One challenge is determining when to start TKI therapy. Decision-making should be shared between patients and multidisciplinary caregiver...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Verburg, Frederik A. Amthauer, Holger Binse, Ina Brink, Ingo Buck, Andreas Darr, Andreas Dierks, Christine Koch, Christine K önig, Ute Kreissl, Michael C. Luster, Markus Reuter, Christoph Scheidhauer, Klemens Willenberg, Holger Sven Zielke, Andreas Schot Tags: Review Source Type: research

Predicting the Relapse of Hyperthyroidism in Treated Graves ’ Disease with Orbitopathy by Serial Measurements of TSH-Receptor Autoantibodies
Horm Metab Res DOI: 10.1055/a-1373-5523The aim of this study was to investigate the potential of the new TSH-receptor antibody (TRAb) assays to predict remission or relapse of hyperthyroidism in patients with Graves’ disease (GD) and Graves’ orbitopathy (GO). TRAbs were measured retrospectively in sera from a cohort of GD patients with GO (n=117; remission n=38 and relapse n=79–Essen GO biobank) with automated binding immunoassays: TRAb Elecsys (Cobas Roche) and TRAb bridge assay (IMMULITE, Siemens), and the TSAb (thyroid stimulating Ab) cell-based bioassay (Thyretain, Quidel Corp.). To identify relapse r...
Source: Hormone and Metabolic Research - February 22, 2021 Category: Endocrinology Authors: St öhr, Mareile Oeverhaus, Michael Lytton, Simon D. Horstmann, Mareike Zwanziger, Denise M öller, Lars Stark, Achim F ührer-Sakel, Dagmar Bechrakis, Nikolaos Berchner-Pfannschmidt, Utta Banga, J. Paul Philipp, Svenja Eckstein, Anja Tags: Endocrine Care Source Type: research

Long-Term Follow-Up of Denosumab Discontinuers with Multiple Vertebral Fractures in the Real-World: A Case Series
Horm Metab Res DOI: 10.1055/a-1368-4218Denosumab discontinuation is associated with rapid reversal of bone turnover suppression and with a considerable increase in fracture risk, including a risk for multiple vertebral fractures (MVF). Long-term follow-up of patients who sustained MVF after denosumab discontinuation has not been reported. This case-series was aimed to provide a long-term follow-up on the management and outcome of denosumab discontinuers who initially presented with multiple vertebral fractures. Denosumab discontinuers were identified from a computerized database of...
Source: Hormone and Metabolic Research - February 15, 2021 Category: Endocrinology Authors: Tripto-Shkolnik, Liana Liel, Yair Yekutiel, Naama Goldshtein, Inbal Tags: Endocrine Care Source Type: research

Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy
We describe a retrospective assessment of subjects with diabetes, with and without COVID-19 infection, during the circuit breaker period of 7th April to 1st June 2020 managed through Tan Tock Seng Hospital’s telehealth platform. The virtual health applications consisted of telephone consultations, video telehealth visits via smartphones, and remote patient monitoring. The TTSH team intensively managed 298 diabetes patients using a telehealth strategy. The group comprised of (1) 84 inpatient COVID-19 patients with diabetes who received virtual diabetes education and blood glucose management during their hospitalisatio...
Source: Hormone and Metabolic Research - February 2, 2021 Category: Endocrinology Authors: Lian, Xia Dalan, Rinkoo Seow, Cherng Jye Liew, Huiling Jong, Michelle Chew, Daniel Lim, Brenda Lin, Anita Goh, Eunice Goh, Christina Othman, Noorani Bte Tan, Lucy Boehm, Bernhard O. Tags: Endocrine Care Source Type: research

Genetic and Epigenetic Characteristics of Autosomal Dominant Pseudohypoparathyroidism Type 1B: Case Reports and Literature Review
In this study, 3.0 kb STX16 deletion causes isolated LOM at exon A/B in two families, which is the most common genetic mutation of AD-PHP1B. The deletion involving NESP55 or AS or genomic rearrangements of GNAS can also result in AD-PHP1B, but it's rare. LOM at exon A/B DMR is prerequisite methylation defect of AD-PHP1B. STX16 and NESP55 directly control the imprinting at exon A/B, while AS controls the imprinting at exon A/B by regulating the transcriptional level of NESP55. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  | &n...
Source: Hormone and Metabolic Research - January 29, 2021 Category: Endocrinology Authors: Luo, Dandan Qi, Xiangyu Liu, Luna Su, Yu Fang, Li Guan, Qingbo Tags: Review Source Type: research

Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population
Horm Metab Res 2021; 53: 105-111 DOI: 10.1055/a-1342-7098There is a paucity of data on the relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and cardiometabolic biomarkers in the Chinese population. To comprehensively and quantitatively examine the association of 25(OH)D and cardiometabolic traits, we conducted a cross-sectional study in the Chinese rural population. Serum 25(OH)D and eight cardiometabolic biomarkers were measured in 1714 individuals from Henan province, China. Scatter plot was used to visualize the distribution and correlation of 25(OH)D and cardiometabolic indicators. Moreover, multivari...
Source: Hormone and Metabolic Research - January 29, 2021 Category: Endocrinology Authors: Zhang, Dongdong Cheng, Cheng Wang, Yan Xue, Yuan Liu, Yiming Li, Wenjie Li, Xing Tags: Endocrine Care Source Type: research

Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Premenopausal Women with Metabolic Syndrome
In conclusion, the present study documented a combined inter-relation between MetS, IR, and NAFLD in premenopausal women with MetS. IR is correlated with NAFLD grade. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 29, 2021 Category: Endocrinology Authors: El-Sehrawy, Amr Ali State, Omnia Elzehery, Rasha Rizk Mohamed, Ahmed Salem Tags: Endocrine Care Source Type: research

Development and Prospective Validation of the Levothyroxine Dose Prediction Model in Primary Hypothyroidism
Horm Metab Res DOI: 10.1055/a-1336-3502Multiple visits are needed to achieve euthyroidism on levothyroxine in newly detected primary hypothyroidism. We aimed to develop a levothyroxine dose estimation algorithm for primary hypothyroidism. Adults with newly diagnosed hypothyroidism were enrolled prospectively, first in the training cohort, followed by the validation cohort separated by time and person. We developed a predictive algorithm from Training Cohort and validated the model in Validation Cohort. Training Cohort: In this cohort, 358 subjects (259 women and 99 men) were enroll...
Source: Hormone and Metabolic Research - January 13, 2021 Category: Endocrinology Authors: Singh, Rekha Tandon, Ashwani Awasthi, Ashish Tags: Endocrine Care Source Type: research

Atherosclerotic Burden and Arterial Stiffness are Not Increased in Patients with Milder Forms of Primary Aldosteronism Compared to Patients with Essential Hypertension
This study shows that subclinical atherosclerotic burden and arterial stiffness in patients with milder forms of PA is comparable to patients with EH. Nevertheless, specific treatment for PA significantly improved cPWV, which argues for a more liberal use of mineralocorticoid receptor antagonists in patients with arterial hypertension. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 13, 2021 Category: Endocrinology Authors: Lottspeich, Christian K öhler, Anton Czihal, Michael Heinrich, Daniel A. Schneider, Holger Handgriff, Laura Reincke, Martin Adolf, Christian Tags: Endocrine Care Source Type: research

Serum Levels and Adipose Tissue Gene Expression of Cathelicidin Antimicrobial Peptide (CAMP) in Obesity and During Weight Loss
Horm Metab Res DOI: 10.1055/a-1323-3050CAMP (Cathelicidin antimicrobial peptide) is synthesized and secreted by adipocytes and involved in adipose tissue (AT) innate immune response and host defense of subcutaneous AT against Gram positive bacteria. Data on the regulation of CAMP in obesity and during weight loss are scarce and reference values do not exist. Serum CAMP levels (ELISA) and AT gene expression levels (quantitative real time PCR) were investigated in two large and longitudinal (12 months) cohorts of severely obese patients undergoing either a low calorie diet (LCD; n=79...
Source: Hormone and Metabolic Research - January 12, 2021 Category: Endocrinology Authors: Hochberg, Alexandra Patz, Marissa Karrasch, Thomas Sch äffler, Andreas Schmid, Andreas Tags: Endocrine Care Source Type: research

Obesity is Associated with Poor Covid-19 Outcomes: A Systematic Review and Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1326-2125Our aim was to assess the association between obesity and the risk of unfavourable outcomes (composite of severe disease and mortality) in inpatients with COVID-19. We conducted a systematic search of databases between December 2019 and 28th June 2020. Studies were included if they reported or allowed estimation of an odds ratio (OR) for unfavourable outcome in obese compared to non-obese patients hospitalised for COVID-19. Twenty cohort studies of 28 355 hospitalised patients with COVID-19 infection were included. Meta-analysis estimated a pooled OR of 2.02 (1.41–2.89, p
Source: Hormone and Metabolic Research - January 4, 2021 Category: Endocrinology Authors: Hoong, Caroline Wei Shan Hussain, Ikram Aravamudan, Veeraraghavan Meyyur Phyu, Ei Ei Lin, Jaime Hui Xian Koh, Huilin Tags: Review Source Type: research

A Big Thank You to our Reviewers in the Past Year!
Horm Metab Res 2021; 53: 6-8 DOI: 10.1055/a-1319-5554 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 4, 2021 Category: Endocrinology Tags: Editorial Source Type: research

Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1
This study aimed to explore a novel biomarker for the progression and prognosis of PTC. A set of 118 patients with PTC were collected from the Affiliated Hospital of Qingdao University. qRT-PCR was used to detect the expression of miR-127 in PTC tissues and cells. The association between miR-127 expression and the clinicopathological features of patients were evaluated by the χ2 test, and the prognostic value of miR-127 was evaluated by Kaplan–Meier analysis and Cox regression analysis. The effect of miR-127 on cell proliferation, migration, and invasion of PTC was analyzed by CCK-8 and transwell assay. miR-127 w...
Source: Hormone and Metabolic Research - December 18, 2020 Category: Endocrinology Authors: Sun, Yinghe Sun, Wenhai Hua, Hui Zhang, Jianhua Yu, Qianqian Wang, Jueru Liu, Xiaomin Dong, Anbing Tags: Endocrine Research Source Type: research

Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis
Horm Metab Res DOI: 10.1055/a-1322-29433-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme of the mevalonate pathway, which generates cholesterol and non-sterol compounds such as isoprenoid, which are involved in key steps of tumorigenesis such as cell growth and proliferation. Our aim was to evaluate the role of the mevalonate pathway in adrenocortical tumors (ACTs). Expression pattern of HMGCR, FDFT1, LDLR, SCARB1, StAR, TSPO, CYP11A1, CYP11B1, CYP17A1, CYP21A1, and HSD3B1 genes, involved in the mevalonate pathway and steroidogenesis, was quantified by real-time RT-PCR in 46 ACT [14 adenom...
Source: Hormone and Metabolic Research - December 11, 2020 Category: Endocrinology Authors: Lima-Valassi, Helena Panteliou Lerario, Antonio Marcondes Montenegro, Luciana Ribeiro Fragoso, Maria Candida Barisson Villares Almeida, Madson Queiroz Mendonca, Berenice Bilharinho Lin, Chin Jia Tags: Endocrine Research Source Type: research

Correction: Investigating the Metabolic Model in Preterm Neonates by Tandem Mass Spectrometry: A Cohort Study
Horm Metab Res DOI: 10.1055/a-1325-3731 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 10, 2020 Category: Endocrinology Authors: Wang, Benjing Zhang, Qin Wang, Qi Ma, Jun Cao, Xiaoju Chen, Yaping Pan, Yuhong Li, Hong Xiang, Jingjing Wang, Ting Tags: Erratum Source Type: research

Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1 α Signaling Pathway in Male NAFLD Mice
Horm Metab Res DOI: 10.1055/a-1293-8250Resistin was identified as a link between obesity and insulin resistance and is associated with many diseases in mice. Deciphering the related development and molecular mechanism is necessary for the treatment of these diseases. Previous studies have revealed that increased resistin levels are correlated with lipid accumulation and play a role in non-alcoholic fatty liver disease (NAFLD) development. However, the exact mechanisms underlying these processes remain unclear. To further clarify whether acute elevated resistin level exacerbated liver steatosis, a high-fat diet-induced NAFL...
Source: Hormone and Metabolic Research - December 10, 2020 Category: Endocrinology Authors: Wen, Fengyun Shi, Zhuoyan Liu, Xiaoping Tan, Yuguang Wei, Lan Zhu, Xuemin Zhang, Hui Zhu, Xiaohuan Meng, Xiangmiao Ji, Weixia Yang, Mengting Lu, Zhaoxuan Tags: Endocrine Research Source Type: research

The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice
Horm Metab Res 2020; 52: 869-876 DOI: 10.1055/a-1301-2378Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8–9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8),...
Source: Hormone and Metabolic Research - December 1, 2020 Category: Endocrinology Authors: De Munck, Toon J.I. Xu, Pan Vanderfeesten, Brechtje L.J. Elizalde, Montserrat Masclee, Ad A.M. Nevens, Frederik Cassiman, David Schaap, Frank G. Jonkers, Daisy M.A.E. Verbeek, Jef Tags: Endocrine Research Source Type: research

Investigating the Metabolic Model in Preterm Neonates by Tandem Mass Spectrometry: A Cohort Study
Horm Metab Res DOI: 10.1055/a-1300-2294The changes of metabolite profiles in preterm birth have been demonstrated using newborn screening data. However, little is known about the holistic metabolic model in preterm neonates. The aim was to investigate the holistic metabolic model in preterm neonates. All metabolite values were obtained from a cohort data of routine newborn screening. A total of 261 758 newborns were recruited and randomly divided into a training subset and a testing subset. Using the training subset, 949 variates were considered to establish a logistic regression model for identifying preterm birth (80% ac...
Source: Hormone and Metabolic Research - November 27, 2020 Category: Endocrinology Authors: Wang, Benjing Zhang, Qin Wang, Qi Ma, Jun Cao, Xiaoju Chen, Yaping Pan, Yuhong Li, Hong Xiang, Jingjing Wang, Ting Tags: Endocrine Care Source Type: research

The Role of Glucocorticoids in the Management of COVID-19
Horm Metab Res DOI: 10.1055/a-1300-2550Coronavirus disease 2019 (COVID-19), caused by an infection with the novel coronavirus SARS-CoV-2, has resulted in a global pandemic and poses an emergency to public health systems worldwide. COVID-19 is highly infectious and is characterized by an acute respiratory illness that varies from mild flu-like symptoms to the life-threatening acute respiratory distress syndrome (ARDS). As such, there is an urgent need for the development of new therapeutic strategies, which combat the high mortality in severely ill COVID-19 patients. Glucocorticoids are a frontline treatment for a diverse r...
Source: Hormone and Metabolic Research - November 18, 2020 Category: Endocrinology Authors: Alexaki, Vasileia Ismini Henneicke, Holger Tags: Review Source Type: research

Does SGLT2 Inhibition Affect Sympathetic Nerve Activity in Type 2 Diabetes?
Horm Metab Res DOI: 10.1055/a-1298-4205SGLT2 inhibitors increase renal glucose excretion and thus decrease both fasting and postprandial plasma glucose levels. The effects of SGLT2 inhibition outweigh those on glycemic control and are also associated with the induction of hemodynamic changes that improve cardiovascular and renal function in people with type 2 diabetes. The exact mechanisms have not yet been completely clarified. This review is focused on the potential relationship between SGLT2 inhibition and sympathetic nerve activity. There is accumulating evidence for a suppressive effect of SGLT2 inhibitors on the symp...
Source: Hormone and Metabolic Research - November 17, 2020 Category: Endocrinology Authors: Dimova, Rumyana Tankova, Tsvetalina Tags: Review Source Type: research

miR-381 Targets KCTD15 to Regulate Bovine Preadipocyte Differentiation In Vitro
Horm Metab Res DOI: 10.1055/a-1276-1602MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs ~21 to ~23 nucleotides in length and have become a popular research topic in recent years due to their regulation of gene expression and many physiological processes, including fat metabolism; however, the precise functional mechanisms underlying their regulation of fat metabolism are not fully understood. Here, we identified miR-381, which specifically targets the 3′ untranslated region (3′ UTR) of potassium channel tetramerization-domain-containing 15 (KCTD15) , and verified the mechanism regulating its expres...
Source: Hormone and Metabolic Research - November 2, 2020 Category: Endocrinology Authors: Xu, Hongyan Shao, Jing Fang, Jiachen Yin, Baozhen Zhang, Luomeng Zhang, Jiasu Xia, Guangjun Tags: Endocrine Research Source Type: research

High Prevalence of Adrenal Remnant Tissue in Patients Undergoing Bilateral Adrenalectomy for Cushing ’s Disease
Horm Metab Res DOI: 10.1055/a-1253-2854Bilateral adrenalectomy (BLA) is a treatment option for patients with Cushing’s Disease (CD) if transsphenoidal pituitary surgery fails or is not a therapeutic option. For most patients, BLA eliminates endogenous glucocorticoid and mineralocorticoid production, but for a small number of patients, endogenous secretion of adrenal hormones from adrenal tissue continues or recurs, leading to signs and symptoms of hypercortisolism. If adrenal tissue is confined to the adrenal bed, it is considered adrenal remnant tissue, while if it is outsi...
Source: Hormone and Metabolic Research - October 22, 2020 Category: Endocrinology Authors: Wilson, Julian B. Zopey, Mohan Augustine, Jaimie Schaffer, Randolph Chiang, Manfred Friedman, Theodore C. Tags: Endocrine Care Source Type: research

Predicitve Value of FDG Uptake in the Remaining Adrenal Gland Following Adrenalectomy for Adrenocortical Cancer
The objective of the study was to investigate a possible correlation between FDG-PET activity of the remaining adrenal gland and therapeutic response of mitotane treatment. This is a retrospective study enrolling patients from two German centers with operated ACC and minimal information on PET-CT scanning. Eighty-two ACC patients after adrenalectomy were included (66 treated with mitotane and 16 without medical therapy). FDG uptake of the contralateral adrenal gland, liver and mediastinum was analyzed from a total of 291 PET/CT scans (median 4 scans per patient) and correlated with c...
Source: Hormone and Metabolic Research - October 21, 2020 Category: Endocrinology Authors: Loewe, Ruben Rogowski-Lehmann, Natalie Pfluger, Thomas Reincke, Martin Hahner, Stefanie Bluemel, Christina Fassnacht, Martin Beuschlein, Felix Tags: Endocrine Care Source Type: research

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis
In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 13, 2020 Category: Endocrinology Authors: Isnuwardana, Ronny Bijukchhe, Sanjeev Thadanipon, Kunlawat Ingsathit, Atiporn Thakkinstian, Ammarin Tags: Endocrine Care Source Type: research

The Effect of Pituitary Gland Disorders on Glucose Metabolism: From Pathophysiology to Management
Horm Metab Res DOI: 10.1055/a-1258-8625This review aims to explore, present, and discuss disorders of glucose metabolism implicated in pituitary gland diseases, the appropriate interventions, as well as the therapeutic challenges that may arise. Pituitary pathologies may dysregulate glucose homeostasis, as both the excess and deficiency of various pituitary hormones can affect glucose metabolism. Increased circulating levels of growth hormone, glucocorticoids or prolactin have been shown to mainly provoke hyperglycemic states, while hypopituitarism can be associated with both hyperglycemia and hypoglycemia. Addressing the ...
Source: Hormone and Metabolic Research - October 12, 2020 Category: Endocrinology Authors: Sydney, Guy I. Michalakis, Konstantinos Nikas, Ilias P. Spartalis, Eleftherios Paschou, Stavroula A. Tags: Review Source Type: research

Blockade of CCL2/CCR2 Signaling Pathway Exerts Anti-Inflammatory Effects and Attenuates Gestational Diabetes Mellitus in a Genetic Mice Model
Horm Metab Res DOI: 10.1055/a-1250-8221The chemokine (C-C motif) ligand 2 (CCL2) and its receptor CCR2 are involved in gestational diabetes mellitus (GDM). The present study aims to explore the effects of CCL2 blocking on GDM. Serum CCL2, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were determined in GDM patients and healthy volunteers. C57BL/KsJdb/+mouse was used as the GDM model and CCL2 antibody (αCCL2) was applied. Flow cytometry was applied to determine the frequency of macrophages. Quantitative reverse transcription PCR (RT-qPCR) and western blot were determined to detect the mRNA and protein ex...
Source: Hormone and Metabolic Research - October 5, 2020 Category: Endocrinology Authors: Qi, Xinying Xing, Yanping Wang, Xuezhen Tags: Endocrine Research Source Type: research

Recombinant Human Thyrotropin-Stimulated Radioiodine Therapy in Patients with Multinodular Goiters: A Meta-Analysis of Randomized Controlled Trials
Horm Metab Res DOI: 10.1055/a-1240-5058A potential reduction of goiter volume (GV) of recombinant human thyrotropin (rhTSH) on multinodular goiters (MNG) was previously reported but controversial. Hence we conducted a meta-analysis to estimate the effect of rhTSH-stimulated radioiodine therapy in patients with MNG. PubMed, Cochrane, CNKI, VIP, and Wanfang databases were searched. Mean difference (MD) and odds ratios with 95% confidence intervals (95% CI) were derived by using an inverse variance random-effects model and fixed-effects model, respectively. Six studies (n=237) were involved ...
Source: Hormone and Metabolic Research - September 21, 2020 Category: Endocrinology Authors: Xu, Chunmei Wang, Ping Miao, Huikai Xie, Tianyue Zhou, Xiaojun Zhang, Qian Jiang, Shan Zhang, Rui Liao, Lin Dong, Jianjun Tags: Endocrine Care Source Type: research

Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence
Horm Metab Res DOI: 10.1055/a-1243-5462COVID-19 is a global pandemic with high mortality in vulnerable groups. Given the current lack of definitive treatment or vaccine that significantly reduces mortality rate, governments, researchers and healthcare providers are racing to find possible solutions to the crisis. Vitamin D and its analogues have been previously studied for their non-skeletal benefits. In particular, questions regarding their role in the modulation of immunity have re-surfaced, in view of possible epidemiological links observed between COVID-19 and vitamin D levels in sele...
Source: Hormone and Metabolic Research - September 16, 2020 Category: Endocrinology Authors: Hoong, Caroline Wei Shan Huilin, Koh Cho, Sanda Aravamudan, Veeraraghavan Meyyur Lin, Jaime Hui Xian Tags: Review Source Type: research

Insights Into the Controversial Aspects of Adiponectin in Cardiometabolic Disorders
Horm Metab Res DOI: 10.1055/a-1239-4349In 2016, the World Health Organization estimated that more than 1.9 billion adults were overweight or obese. This impressive number shows that weight excess is pandemic. Overweight and obesity are closely associated with a high risk of comorbidities, such as insulin resistance and its most important outcomes, including metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. Adiponectin has emerged as a salutary adipocytokine, with insulin-sensitizing, anti-inflammatory, and cardiovascular protective properties. However, under metabo...
Source: Hormone and Metabolic Research - September 13, 2020 Category: Endocrinology Authors: Francischetti, Emilio Antonio Dezonne, R ômulo Sperduto Pereira, Cl áudia Maria de Moraes Martins, Cyro Jos é Celoria, Bruno Miguel Jorge de Oliveira, Patr ícia Aguiar Cardoso de Abreu, Virg ínia Genelhu Tags: Review Source Type: research

Correction: Associations of Thyroid Hormones and Resting Heart Rate in Patients Referred to Coronary Angiography
Horm Metab Res DOI: 10.1055/a-1260-4769 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 13, 2020 Category: Endocrinology Authors: Steinberger, Eva Pilz, Stefan Trummer, Christian Theiler-Schwetz, Verena Reichhartinger, Markus Benninger, Thomas Pandis, Marlene Malle, Oliver Keppel, Martin H. Verheyen, Nicolas Gr übler, Martin R. Voelkl, Jakob Meinitzer, Andreas M ärz, Winfried Tags: Erratum Source Type: research

COVID-19 in Children and Adolescents with Endocrine Conditions
Horm Metab Res DOI: 10.1055/a-1227-6635The rapid spread of coronavirus disease (COVID-19) worldwide justifies global effort to combat the disease but also the need to review effective preventive strategies and medical management for potentially high-risk populations during the pandemic. Data regarding the COVID-19 manifestations in adults with underlying endocrine conditions, especially diabetes mellitus, are increasingly emerging. Albeit children and adolescents are considered to be affected in a milder manner, paucity of information regarding COVID-19 in children who suffer from endocri...
Source: Hormone and Metabolic Research - September 7, 2020 Category: Endocrinology Authors: Kostopoulou, Eirini G üemes, Maria Shah, Pratik Tags: Review Source Type: research

Associations of Thyroid Hormones and Resting Heart Rate in Patients Referred to Coronary Angiography
Horm Metab Res DOI: 10.1055/a-1232-7292Resting heart rate (RHR) is associated with increased risk of cardiovascular morbidity and mortality. Thyroid hormones exert several effects on the cardiovascular system, but the relation between thyroid function and RHR remains to be further established. We evaluated whether measures of thyroid hormone status are associated with RHR in patients referred to coronary angiography. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxin (FT4), and RHR were determined in 2795 participants of the Ludwigshafen Risk and Cardiovascular ...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Steinberger, Eva Pilz, Stefan Trummer, Christian Theiler-Schwetz, Verena Reichhartinge, Markus Benninger, Thomas Pandis, Marlene Malle, Oliver Keppel, Martin H. Verheyen, Nicolas Gr übler, Martin R. Voelkl, Jakob Meinitzer, Andreas M ärz, Winfried Tags: Endocrine Care Source Type: research

Associations of the LPL S447X and Hind III Polymorphism with Type 2 Diabetes Mellitus Risk: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1229-1604The present study was aimed to evaluate the association of lipoprotein lipase (LPL) gene (S447X and Hind III) polymorphisms and T2DM. Relevant studies were identified through systematic search PubMed, Cochrane Library, Embase, Wanfang, CNKI databases. A total of 22 studies (8 studies for LPL S447X and 14 studies for Hind III) were included. The results showed that the LPL S447X polymorphism was associated with the low risk of T2DM under dominant and allelic genetic models. Subgroup analysis by ethnicity showed that the LPL S447X polymorphism was asso...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Liu, Na Sang, Yan Chen, Shengzhi Liu, Xiaoming Tags: Endocrine Care Source Type: research