Paragangliomas in Carney –Stratakis Syndrome
Horm Metab Res DOI: 10.1055/a-0918-8340Carney-Stratakis Syndrome (CSS) comprises of paragangliomas (PGLs) and gastrointestinal stromal tumors (GISTs). Several of its features overlap with Carney Triad (CT) - PGLs, GISTs, and pulmonary chondromas. CSS has autosomal dominant inheritance, incomplete penetrance, and greater relative frequency of PGL over GISTs. The PGLs in CSS are multicentric and GISTs are multifocal in all the patients, suggesting an inherited susceptibility and associating the two manifestations. In this review, we highlight the clinical, pathological, and molecular characteristics of CSS, along with its di...
Source: Hormone and Metabolic Research - June 7, 2019 Category: Endocrinology Authors: Khurana, Arushi Mei, Lin Faber, Anthony C. Smith, Steven C. Boikos, Sosipatros A. Tags: Review Source Type: research

Inhibition of Type 1 Iodothyronine Deiodinase by Bisphenol A
Horm Metab Res DOI: 10.1055/a-0919-3879Plastics are ubiquitously present in our daily life and some components of plastics are endocrine-disrupting chemicals, such as bisphenol A and phthalates. Herein, we aimed to evaluate the effect of plastic endocrine disruptors on type 1 and type 2 deiodinase activities, enzymes responsible for the conversion of the pro-hormone T4 into the biologically active thyroid hormone T3, both in vitro and in vivo. Initially, we incubated rat liver type 1 deiodinase and brown adipose tissue type 2 deiodinase samples with 0.5 mM of the plasticizers, and the deiodinase activity was measured. Amon...
Source: Hormone and Metabolic Research - June 7, 2019 Category: Endocrinology Authors: da Silva, Maur ício Martins Gon çalves, Carlos Frederico Lima Miranda-Alves, Leandro Fortunato, Rodrigo Soares Carvalho, Denise P. Ferreira, Andrea Claudia Freitas Tags: Endocrine Research Source Type: research

Association Between Urinary Catecholamine Excretion and Urine Volume
Horm Metab Res DOI: 10.1055/a-0926-3532Several confounders must be considered in the evaluation of urinary catecholamine excretion. However, literature is contradictory about potential confounders. The aim of the present study was to assess correlations between catecholamine excretion and anthropometric or clinical parameters with special attention to urine volume. A total of 967 24-h urinary catecholamine measurements were performed in 593 patients for diagnostic purposes. The indication for urine examination was suspicion of secondary hypertension, phaeochromocytoma, or paraganglioma. From the patients examined, 57% were...
Source: Hormone and Metabolic Research - June 7, 2019 Category: Endocrinology Authors: Haap, Michael Blaschka, Friedemann Lehmann, Rainer Hoyer, Annika M üssig, Karsten Tags: Endocrine Care Source Type: research

Association Between Visfatin and Hepatic Steatosis in the General Population During Long-Term Follow-Up
Horm Metab Res DOI: 10.1055/a-0897-8565The aim of this study was to investigate any association between the adipose tissue-derived protein, visfatin, and non-alcoholic fatty liver disease (NAFLD) and its potential long-term impact on hepatic steatosis. A cross-sectional study including 2429 randomly selected subjects was performed in 2002. Later, 403 subjects were re-evaluated in 2013. Serum visfatin concentrations were determined by sandwich enzyme-linked immunosorbent assay. Phenotyping included abdominal ultrasonography, anthropometric data, and laboratory investigations. No association was found between circulating vis...
Source: Hormone and Metabolic Research - May 27, 2019 Category: Endocrinology Authors: Johannsen, Katharina Flechtner-Mors, Marion Kratzer, Wolfgang Koenig, Wolfgang Boehm, Bernhard Otto Schmidberger, Julian Tags: Endocrine Care Source Type: research

Effects of Different Fasting Durations on Glucose and Lipid Metabolism in Sprague Dawley Rats
In conclusion, extending the fasting duration had an impact on glucose metabolism in rats, but did not appear to influence fat tolerance. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 23, 2019 Category: Endocrinology Authors: Rakvaag, Elin Lund, Majbritt Dam Wiking, Lars Hermansen, Kjeld Gregersen, S øren Tags: Endocrine Research Source Type: research

Effect of Metformin Treatment on Insulin Resistance Markers, and Circulating Irisin in Women with Polycystic Ovarian Syndrome (PCOS)
This study was aimed to examine circulating irisin levels and effects of metformin on this parameter in women with PCOS. Moreover, the association of irisin with insulin resistance markers was determined. Thirty-nine females with PCOS, aged 20–40 years, participated in this study and received 500 mg of metformin once daily for 3 months. Serum creatinine, blood urea nitrogen, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), cholesterol, triglyceride, fasting blood sugar, testosterone, 17-hydroxyprogesterone, and irisin were assayed in the studied groups. Circulating irisin was signif...
Source: Hormone and Metabolic Research - May 23, 2019 Category: Endocrinology Authors: Masaeli, Asiyeh Nayeri, Hashem Mirzaee, Mohammadreza Tags: Endocrine Care Source Type: research

Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity
Horm Metab Res DOI: 10.1055/a-0887-2770The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, the increase in oxidative stress and the dysregulation of the matrix metalloprotease (MMP) concentration and activity. In a group of adults with obesity, divided in 2 subgroups according to the body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, expressed as protein carbonyl groups (PCs), plasma gelatinases (MMP-2 and MMP-9), and their tissue inhibitors (TIMP...
Source: Hormone and Metabolic Research - May 10, 2019 Category: Endocrinology Authors: Caimi, Gregorio Canino, Baldassare Montana, Maria Urso, Caterina Calandrino, Vincenzo Presti, Rosalia Lo Hopps, Eugenia Tags: Endocrine Research Source Type: research

Prevalence of Dyslipidaemia and Pre-Diabetes Among Women with Polycystic Ovary Syndrome (PCOS): Do We Overestimate Cardiovascular Risk?
Horm Metab Res DOI: 10.1055/a-0896-4144PCOS is widely accepted as associated with an increased cardiovascular risk, however, without convincing evidence of an increased cardiovascular mortality. We assessed prevalence of obesity, glucose intolerance, and dyslipidaemia in 490 women with PCOS, aged 24.75±8.05 years, diagnosed according to the Rotterdam consensus criteria. Fifty-two percent of women had BMI
Source: Hormone and Metabolic Research - May 10, 2019 Category: Endocrinology Authors: Lewandowski, Krzysztof C. P łusajska, Justyna Horzelski, Wojciech Lewi ński, Andrzej Tags: Endocrine Care Source Type: research

Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?
Horm Metab Res 2019; 51: 326-329 DOI: 10.1055/a-0885-7169Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In thi...
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Straube, Richard Voit-Bak, Karin Gor, A. Steinmeier, Til Chrousos, George P. Boehm, Bernhard Otto Birkenfeld, Andreas L. Barbir, Mahmoud Balanzew, Wladimir Bornstein, Stefan R. Tags: Endocrine Care Source Type: research

The Cycle Characteristics and Outcomes of Infertile Nonclassic 21-Hydroxylase Deficiency Patients Undergoing Ovarian Stimulation for In Vitro Fertilization
Conclusion In COH cycles, the ultrasonographic appearance of ovary helps to predict the number of viable embryos. In ET cycles, dexamethasone obviously improves the pregnancy rate. If the minimum P4 value before endometrial transformation cannot be kept below 0.45 ng/ml, we may consider cycle cancellation. Moreover, it is suggested that BMI of nonclassic 21-OHD women is regulated below 23.36 kg/m2. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Jiang, Shutian Kuang, Yanping Tags: Endocrine Care Source Type: research

Pattern of Lipid Abnormalities Among South Asian Indians With Cushing ’s Syndrome and the Short Term Impact of Surgical Correction of Hypercortisolism
Horm Metab Res 2019; 51: 309-314 DOI: 10.1055/a-0879-5122Atherosclerotic cardiovascular events are one of the common causes of mortality in patients with Cushing’s syndrome (CS). Atherogenic dyslipidemia is more common among South Asian Indians as compared to other ethnicities and is likely to worsen among patients with CS. This retrospective study was done over 5 years at a single institute to evaluate the pattern of lipid abnormalities in subjects with CS and the changes in lipid parameters after surgical control of hypercortisolemia. The study was done in two parts. In the first part, records of patients with CS d...
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Dhingra, Atul Ganie, Mohd Ashraf Dharmshaktu, Pramila Chakraborty, Semanti Jyotsna, Viveka P. Gupta, Nandita Tags: Endocrine Care Source Type: research

Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto ’s Thyroiditis? A Double Blind, Randomized Clinical Trial
Horm Metab Res 2019; 51: 296-301 DOI: 10.1055/a-0856-1044Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune disorder characterized by the destruction of thyroid cells caused by leukocytes and antibody-mediated immune processes accompanied by hypothyroidism. In recent years, evidence has emerged pointing to various roles for vitamin D, including, proliferation and differentiation of normal and cancer cells, cardiovascular function, and immunomodulation. Vitamin D deficiency has been especially demonstrated in HT patients. The aim of this study was to investigate the effect of vitamin D on circulating thyroi...
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Chahardoli, Reza Saboor-Yaraghi, Ali-Akbar Amouzegar, Atieh Khalili, Davood Vakili, Azita Zadeh Azizi, Fereidoun Tags: Endocrine Care Source Type: research

Effect of Calcium ‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Horm Metab Res 2019; 51: 288-295 DOI: 10.1055/a-0887-0205We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of calcium-vitamin D co‑supplementation on insulin, insulin sensitivity, and glycemia. A systematic search was carried out in Web of Science, PubMed, EMBASE, Scopus, and Cochrane library without any language and time restriction up to 12 August 2018, to retrieve the RCTs, which examined the effect of calcium and vitamin D co-supplementation on fasting blood glucose (FBG), insulin, HOMA-B, HOMA-IR, and QUICKI. Meta-analyses were carried out using a random e...
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Asbaghi, Omid Khosroshahi, Mohammad Zeinali Kashkooli, Sara Abbasnezhad, Amir Tags: Review Source Type: research

Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review
Horm Metab Res 2019; 51: 279-287 DOI: 10.1055/a-0890-6823Polycystic ovary syndrome (PCOS), as the most common endocrine disorder in reproductive-aged women, is recognized by hyperandrogenism and insulin resistance. Selenium (Se) potentially possesses therapeutic effects on PCOS due to antioxidant and insulin-like properties. This systematic review evaluates the potential role of Se in the complications of PCOS. A systematic review was performed on published studies reporting the effects of Se on PCOS. Three major databases including PubMed, Scopus, and Google Scholar were searched until December 2018. A total of 7 human st...
Source: Hormone and Metabolic Research - May 9, 2019 Category: Endocrinology Authors: Hajizadeh-Sharafabad, Fatemeh Moludi, Jalal Tutunchi, Helda Taheri, Ehsaneh Izadi, Azimeh Maleki, Vahid Tags: Review Source Type: research

Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome
Horm Metab Res 2019; 51: 261-266 DOI: 10.1055/a-0867-0886The purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. HMWA was determined by enzyme-linked immunosorbent assay and IR was estimated using the homeostasis model assessment of insulin resistance (H...
Source: Hormone and Metabolic Research - April 25, 2019 Category: Endocrinology Authors: Pekcan, Meryem Kuru Tokmak, Aytekin Akkaya, Hatice Pekcan, G ültekin Onur, Anda ç K ısa, Üçler Çil, Aylin Pelin Tags: Endocrine Care Source Type: research

Characterization of a Novel POU1F1 Mutation Identified on Screening 160 Growth Hormone Deficiency Patients
The objective of the study is the functional characterization of a novel POU1F1 c.605delC mutation in combined pituitary hormone deficiency (CPHD) and to report the clinical and genetic details of 160 growth hormone deficiency patients. Screening of GH1, GHRHR, POU1F1, PROP1, and HESX1 genes by Sanger sequencing was carried out in 160 trios and 100 controls followed by characterization of the POU1F1 c.605delC mutation by expression studies including site directed mutagenesis, co-transfection, protein degradation, and luciferase assays to compare the wild type and mutant POU1F1. In vitro studies showed that the POU1F1 c.605...
Source: Hormone and Metabolic Research - April 25, 2019 Category: Endocrinology Authors: Birla, Shweta Vijayakumar, P Sehgal, Shilpi Bhatnagar, Shinjini Pallavi, Kshetrapal Sharma, Arundhati Tags: Endocrine Care Source Type: research

Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis
Horm Metab Res 2019; 51: 230-242 DOI: 10.1055/a-0863-5779We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1.73 ng/ml, 95% CI=1.22 to 2.25, p
Source: Hormone and Metabolic Research - April 25, 2019 Category: Endocrinology Authors: Maleki-Hajiagha, Arezoo Razavi, Maryam Rezaeinejad, Mahroo Sepidarkish, Mahdi Mehri, Ahmad Vesali, Samira Allameh, Zahra Tags: Review Source Type: research

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis
Horm Metab Res 2019; 51: 220-229 DOI: 10.1055/a-0867-1333High blood pressure is related with increased cerebrovascular accident. High visfatin / NAMPT(nicotinamide phosphoribosyltransferase) plasma levels may promote vascular inflammation and atherosclerotic plaque destabilization and have been evaluated as a marker for identifying stages of essential hypertension. However, its role in the pathogenesis of hypertension and cerebrovascular accident (CVA) is still uncertain. In order to review and meta-analyze observational studies investigating visfatin concentration and the risk for hypertension or CVA, a systematic search ...
Source: Hormone and Metabolic Research - April 25, 2019 Category: Endocrinology Authors: Yu, Pu-liang Wang, Cheng Li, Wei Zhang, Feng-Xiao Tags: Review Source Type: research

Correction: Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review
Horm Metab Res DOI: 10.1055/a-0887-1201 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 15, 2019 Category: Endocrinology Authors: Mei, Lin Khurana, Arushi Al-Juhaishi, Taha Faber, Anthony Celi, Francesco Smith, Steven Boikos, Sosipatros Tags: Erratum Source Type: research

Association of High Serum Uric Acid and Increased Arterial Stiffness is Dependent on Cardiovascular Risk Factors in Female Population
This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m2. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular...
Source: Hormone and Metabolic Research - April 11, 2019 Category: Endocrinology Authors: Yuan, Yin Huang, Feng Lin, Fan Lin, Min Zhu, Pengli Tags: Endocrine Care Source Type: research

Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life
Horm Metab Res DOI: 10.1055/a-0876-6007The goal of this study is to investigate whether congenital hypothyroidism induced by MMI during gestation (G) or gestation plus lactation (GL) would affect the leptin action upon body weight control on hypothalamus. Six to eight pups per group were killed at 90 days of age. For statistical analysis one-way ANOVA followed by the Holm–Sìdak post hoc test was used. Hypothyroidism resulted in a significant increase in leptin serum levels in G 20% and GL 25% (p
Source: Hormone and Metabolic Research - April 3, 2019 Category: Endocrinology Authors: Aiceles, Veronica Gombar, Flavia Meireles Cavalcante, Fernanda da Silveira Ramos, Cristiane da Fonte Tags: Endocrine Research Source Type: research

Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review
In conclusion, younger age, female sex, origin from aortic/carotid bodies, complete surgical resection, regional disease, as well as concomitant second primary malignancies were associated with better prognosis. The prognostic value of radiotherapy and oncogenomics warrants further investigation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 27, 2019 Category: Endocrinology Authors: Mei, Lin Khurana, Arushi Al-Juhaishi, Taha Farber, Anthony Celi, Francesco Smith, Steven Boikos, Sosipatros Tags: Endocrine Care Source Type: research

Trabecular Bone Score, Bone Mineral Density and Bone Markers in Patients with Primary Hyperparathyroidism 2 Years After Parathyroidectomy
Horm Metab Res 2019; 51: 186-190 DOI: 10.1055/a-0850-8679Following a parathyroidectomy there is a bone mineral density (BMD) improvement in patients with primary hyperparathyroidism. However, data of bone microarchitecture are scarce. Trabecular bone score (TBS) estimates bone microarchitecture and could provide valuable information in those patients. The aim of this study is to assess TBS changes 2 years after successful surgery in a group of patients with primary hyperparathyroidism and correlate these results with changes in BMD and bone turnover markers. This is a prospective study including 32 patients. In all partici...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: Miguel, Gonzalo Allo Carranza, Federico Hawkins Rodr íguez, Juan Carlos Romero Ramos, Mercedes Aramendi Pablos, David Lora Herrero, Eduardo Ferrero D íaz-Guerra, Guillermo Martínez Tags: Endocrine Care Source Type: research

Quality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma
The objective of the work was to assess the impact of surgery, radiotherapy (RT) and pituitary deficiencies on long term health-related quality of life (QoL) and cognitive function among NFPA patients. Forty-six NFPA patients were studied after 9.6±7.5 years follow-up using: i) the MoCA questionnaire to detect mild cognitive disabilities, ii) the McNair and Kahn scale to assess perceived cognitive impairment, iii) the HADS questionnaire to score anxiety and depression, and iv) the SF-36 and QLS-H questionnaires to assess QoL. All NFPA patients had surgery and 54% patients had radiation therapy (RT+). The MoCA score ...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: Crouzeix, Genevieve Morello, R émy Thariat, Juliette Morera, Julia Joubert, Michael Reznik, Yves Tags: Endocrine Care Source Type: research

Evaluation of Biochemical Conditions Allowing Bypass of Confirmatory Testing in The Workup of Primary Aldosteronism: A Retrospective Study in a French Hypertensive Population
Horm Metab Res 2019; 51: 172-177 DOI: 10.1055/a-0857-1620The diagnostic workup for primary aldosteronism includes a screening step using the aldosterone-to-renin ratio (ARR) and a confirmatory step based on dynamic testing of aldosterone secretion autonomy. International guidelines suggest that precise clinical and biochemical conditions may allow the bypassing of the confirmatory step, however, data which validate hormone thresholds defining such conditions are lacking. At our tertiary center, we retrospectively examined a cohort of 173 hypertensive patients screened for PA by the ARR, of whom 120 had positive screening a...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: Vivien, Maud Deberles, Emilie Morello, Remy Haddouche, Aimi Guenet, David Reznik, Yves Tags: Endocrine Care Source Type: research

Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level
We examined 436 pregnant women in their first trimester of pregnancy, and 444 non-pregnant women in a cross sectional study. Serum levels of thyroid stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, urinary iodine concentration (UIC), and thyroid volume were measured for all subjects. The first trimester-specific reference intervals (2.5th–97.5th percentile) were determined for 185 pregnant women and 256 non-pregnant women with negative TPOAb, adequate iodine level (UIC≥150 μg/l in pregnant and UIC≥100 μg/l in non-pregnant women), and n...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: Kianpour, Maryam Aminorroaya, Ashraf Amini, Massoud Feizi, Awat Janghorbani, Mohsen Shokri, Saeideh Yamini, Sima Aminorroaya Farghadani, Maryam Hekmatnia, Ali Gharib, Hossien Tags: Endocrine Care Source Type: research

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Horm Metab Res 2019; 51: 157-164 DOI: 10.1055/a-0841-6638Melatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta—analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potent...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: Hadi, Amir Ghaedi, Ehsan Moradi, Sajjad Pourmasoumi, Makan Ghavami, Abed Kafeshani, Marzieh Tags: Review Source Type: research

A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors
Horm Metab Res 2019; 51: 145-156 DOI: 10.1055/a-0843-3366Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4), programed cell death 1 (PD-1), or its ligand (PD-L1) have become the mainstay for advanced malignancies. The incidence of endocrine adverse events provoked by these immune checkpoint inhibitors (ICI) is based on data from randomized controlled trials, which have their drawbacks. PubMed was searched through August 22nd, 2017, by 2 reviewers independently (J.d.F. and C.E.A.). Early phase I/II, phase III experimental trials, prospective and retrospective observational studies were included. The w...
Source: Hormone and Metabolic Research - March 12, 2019 Category: Endocrinology Authors: de Filette, Jeroen Andreescu, Corina Emilia Cools, Filip Bravenboer, Bert Velkeniers, Brigitte Tags: Review Source Type: research

Relationships Between Thyroid Hormones, Insulin-Like Growth Factor-1 and Antioxidant Levels in Hypothalamic Amenorrhea and Impact on Bone Metabolism
Horm Metab Res DOI: 10.1055/a-0859-4285Reduced bone mineral density (BMD) in Functional Hypothalamic Amenorrhea (FHA) is mainly related to hypoestrogenism, but other hormonal derangement (reduced conversion of T4–T3 and GH resistance) can play a role. These hormones are involved in antioxidant systems regulation. We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. Forty-three FHA patients, 15–34 years, with BMI range 17.3–23.4 kg/m2, were divided in 2 groups according to fT3 levels; group A (n=22), low fT3 (
Source: Hormone and Metabolic Research - March 7, 2019 Category: Endocrinology Authors: Mancini, Antonio Vergani, Edoardo Bruno, Carmine Barini, Angelina Silvestrini, Andrea Meucci, Elisabetta Messana, Calogero Romualdi, Daniela Apa, Rosanna Lanzone, Antonio Tags: Endocrine Care Source Type: research

Unveiling the Role of Prolactin and its Receptor in Male Reproduction
Horm Metab Res DOI: 10.1055/a-0859-1144Prolactin is a peptide hormone known to have multiple functions. However, the role of prolactin has been extensively studied only in female physiology and its function in male reproduction still remains majorly unexplored. Studies in rodents and humans have demonstrated the presence of prolactin and its receptor in testes, thereby suggesting a possible role during spermatogenesis. Experimental evidences from prolactin and prolactin receptor deficient male rodent models as well as studies done in hypo- and hyper-prolactinemic males hint at neuroendocrine and reproductive abnormalities....
Source: Hormone and Metabolic Research - March 6, 2019 Category: Endocrinology Authors: Raut, Sanketa Deshpande, Sharvari Balasinor, Nafisa H. Tags: Review Source Type: research

Normocalcemic Primary Hyperparathyroidism in Adults Without a History of Nephrolithiasis or Fractures: A Prospective Study
Horm Metab Res DOI: 10.1055/a-0859-1020The prevalence and the diagnostic criterion of “normocalcemic” primary hyperparathyroidism (NPHPT) are still uncertain and there is no consensual definition. This prospective study evaluated the prevalence of NPHPT in 676 adults without a history of fractures or nephrolithiasis and who would be submitted to thyroidectomy, the impact of adopting different cut-off values for 25-hydroxyvitamin D and estimated glomerular filtration rate (eGFR), and the agreement between biochemical diagnosis and the surgical finding of altered parathyroid glands. NPHPT was diagnosed in patient...
Source: Hormone and Metabolic Research - March 6, 2019 Category: Endocrinology Authors: Ros ário, Pedro Weslley Calsolari, Maria Regina Tags: Endocrine Care Source Type: research

Metabolomics and Their Ability to Distinguish Thyroid Disorders: A Retrospective Pilot Study
Horm Metab Res DOI: 10.1055/a-0850-9691Early diagnosis of thyroid disorders is key to further treatment. We assessed the ability of a high-throughput proton NMR metabolomic profile to distinguish disease type amongst of Graves’ disease (n=87), Hashimoto’s thyroiditis (n=17), toxic goiter (n=11), and autoimmune thyroiditis [i. e., subacute thyroiditis (n=4), postpartum thyroiditis (n=1)]. This observational study was conducted investigating patients presenting with a thyroid disorder at a Swiss hospital endocrine referral center and an associated endocrine outpatient clinic. The main outcome was diagnosis...
Source: Hormone and Metabolic Research - February 21, 2019 Category: Endocrinology Authors: Struja, Tristan Eckart, Andreas Kutz, Alexander Neyer, Peter Kraenzlin, Marius Mueller, Beat Meier, Christian Bernasconi, Luca Schuetz, Philipp Tags: Endocrine Care Source Type: research

Reduced Gene Expression of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 α in Whole Blood in Euthyroid Patients One Year After Hemithyroidectomy for Benign Euthyroid Goiter
Horm Metab Res 2019; 51: 127-133 DOI: 10.1055/a-0822-3066We have previously reported decreased thyroid function within the laboratory reference range and changes in mitochondrial function after hemithyroidectomy. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and coactivator-1β (PGC-1β) are key regulators of mitochondrial biogenesis and function. The aim was to examine the influence of hemithyroidectomy on the longitudinal change in mRNA expression of these genes. In addition, we measured longitudinal changes in mRNA expressions of the mitochoncrial-related genes nuclear fa...
Source: Hormone and Metabolic Research - February 13, 2019 Category: Endocrinology Authors: Kristensen, Tina Toft Pedersen, Palle Lyngsie Larsen, Jacob Feldthusen, Anne-Dorthe Jelstrup, S øren Ellervik, Christina Tags: Endocrine Care Source Type: research

Congenital Hypopituitarism: Various Genes, Various Phenotypes
Horm Metab Res 2019; 51: 81-90 DOI: 10.1055/a-0822-3637The ontogenesis and development of the pituitary gland is a highly complex process that depends on a cascade of transcription factors and signaling molecules. Spontaneous mutations and transgenic murine models have demonstrated a role for many of these factors, including HESX1, PROP1, PIT1, LHX3, LHX4, SOX2, SOX3, OTX2, PAX6, FGFR1, SHH, GLI2, and FGF8 in the etiology of congenital hypopituitarism. Genetic mutations in any of these factors can lead to congenital hypopituitarism, which is characterized by the deficiency in one or more pituitary hormones. The phenotype c...
Source: Hormone and Metabolic Research - February 13, 2019 Category: Endocrinology Authors: Xatzipsalti, Maria Voutetakis, Antonis Stamoyannou, Lela Chrousos, George P. Kanaka-Gantenbein, Christina Tags: Review Source Type: research

Effect of IL-6 Receptor Blockade on Proprotein Convertase Subtilisin/Kexin Type-9 and Cholesterol Efflux Capacity in Rheumatoid Arthritis Patients
Horm Metab Res DOI: 10.1055/a-0833-4627The aim of the work was to examine whether abnormalities in the lipid profile that tocilizumab (TCZ), an anti-IL-6 receptor Ab, exerts in rheumatoid arthritis (RA) patients is related to changes in either proprotein convertase subtilisin/kexin-9 (PCSK9) serum concentrations or in serum cholesterol efflux capacity (CEC). TOCRIVAR is a one-year prospective clinical trial that analyzes the influence of TCZ on cardiovascular risk factors. Twenty-seven RA patients receiving TCZ (8 mg/kg IV/q4w) were assessed at baseline and weeks 12, 24, and 52. Disease activity indexes, adiposity c...
Source: Hormone and Metabolic Research - January 29, 2019 Category: Endocrinology Authors: Ferraz-Amaro, Iv án Hern ández-Hernández, María Vanesa Tejera-Segura, Beatriz Delgado-Fr ías, Esmeralda Mac ía-Díaz, María Machado, Jose David Diaz-Gonz ález, Federico Tags: Endocrine Care Source Type: research

Exenatide Delays Gastric Emptying in Patients with Type 2 Diabetes Mellitus but not in Those with Gastroparetic Conditions
Horm Metab Res DOI: 10.1055/a-0818-6374The effect of the treatment with glucagon-like peptide (GLP)-1 receptor agonists on gastric emptying in patients with diabetes with and without gastroparesis is analysed. Patients with type 2 diabetes mellitus subjected to GLP-1 receptor agonist therapy with exenatide were examined before and shortly after initiation of treatment. Gastric half-emptying time was determined by 13C-octanoic breath test; routine laboratory parameter as well as active GLP-1, ghrelin, leptin, insulin, proinsulin and C-peptide levels were determined in fasting state as well as postprandial secretion within 1...
Source: Hormone and Metabolic Research - January 28, 2019 Category: Endocrinology Authors: Beti, Christelle Stratmann, Bernd Bokman, Georgy Dreier, Jens Hauber, Michael Lee-Barkey, Young Hee Fischer, Manfred Knabbe, Cornelius Tschoepe, Diethelm Tags: Endocrine Care Source Type: research

Hormone and Metabolic Research: 50 Years of Research
Horm Metab Res 2019; 51: 8-10 DOI: 10.1055/a-0818-8930 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 21, 2019 Category: Endocrinology Authors: Schott, Matthias R. Bornstein, Stefan A. Stratakis, Constantine Tags: Editorial Source Type: research

A Big Thank You to our Reviewers in the Past Year!
Horm Metab Res 2019; 51: 5-7 DOI: 10.1055/a-0804-3128Good reviewers are essential to the success of any journal and peer review is a major pillar of science. We are grateful to those mentioned below to have dedicated their time and expertise to help our authors improve and refine their manuscripts and support the Editors in the decision making process in the past year. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 21, 2019 Category: Endocrinology Tags: Editorial Source Type: research

Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Horm Metab Res 2019; 51: 22-34 DOI: 10.1055/a-0806-8281While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic paramete...
Source: Hormone and Metabolic Research - January 16, 2019 Category: Endocrinology Authors: Amiri, Mina Tehrani, Fahimeh Ramezani Bidhendi-Yarandi, Razieh Behboudi-Gandevani, Samira Azizi, Fereidoun Carmina, Enrico Tags: Review Source Type: research

Correction: Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery
Horm Metab Res DOI: 10.1055/a-0828-9509 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 14, 2019 Category: Endocrinology Authors: Afshari, Ali Keil, Margaret Lyssikatos, Charalampos Belyavskaya, Elena Vald és, Nuria Chowdhry, Fatima A. Parsa, Kian Ardeshirpour, Yasaman Pursley, Randall Khare, Siddharth Kainerstorfer, Jana M. Chittiboina, Prashant Lodish, Maya B. Mazzuchi, Thomas A. Tags: Erratum Source Type: research

Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery
Horm Metab Res DOI: 10.1055/a-0801-8917We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3–6 months, and 13 patients 12 months post-operative...
Source: Hormone and Metabolic Research - January 2, 2019 Category: Endocrinology Authors: Afshari, Ali Keil, Margaret Lyssikatos, Charalampos Belyavskaya, Elena Vald és, Nuria Chowdhry, Fatima A. Parsa, Kian Ardeshirpour, Yasaman Pursley, Randall Khare, Siddharth Kainerstorfer, Jana M. Chittiboina, Prashant Lodish, Maya B. Mazzuchi, Thomas A. Tags: Endocrine Care Source Type: research

Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis
Horm Metab Res DOI: 10.1055/a-0802-9569The study was aimed to investigate gut hormone responses to mixed meal test in individuals with new-onset prediabetes or diabetes after acute pancreatitis (cases) compared with healthy controls, and the effect of body fat parameters. A total of 29 cases and 29 age- and sex-matched healthy controls were recruited. All participants were given standard mixed meal drink and blood samples were collected to measure dipeptidyl peptidase IV, gastric inhibitory peptide, glucagon like peptide-1, insulin, oxyntomodulin, and peptide YY. Body fat parameters were measured using magnetic resonance i...
Source: Hormone and Metabolic Research - December 20, 2018 Category: Endocrinology Authors: Pendharkar, Sayali A. Singh, Ruma G. Cervantes, Aya DeSouza, Steve V. Bharmal, Sakina H. Petrov, Maxim S. Tags: Endocrine Care Source Type: research

Prediabetes is Characterized by Higher FGF23 Levels and Higher Prevalence of Vitamin D Deficiency Compared to Normal Glucose Tolerance Subjects
In this study, 80 patients with mean age 50.4±10.6 years were included, divided into 2 age- and BMI-matched groups – group 1 with obesity without glycemic disturbances (n=41) and group 2 with obesity and prediabetes (n=39). Oral glucose tolerance test (OGTT) with measurement of immunoreactive insulin was performed in all participants and levels of PTH, 25(OH)D, FGF23, and Klotho were measured. We found significantly higher levels of FGF23 in patients with prediabetes compared to normal glucose tolerance subjects (10.4±10.7 vs. 5.8±7.3 pg/ml; p=0.03). FGF23 showed a weak positive correlatio...
Source: Hormone and Metabolic Research - December 20, 2018 Category: Endocrinology Authors: Gateva, Antoaneta Assyov, Yavor Tsakova, Adelina Kamenov, Zdravko Tags: Endocrine Care Source Type: research

The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials
This study aimed to assess the effect of vitamin D supplementation on patients with prostate cancer. In the present study, PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to September 2017 for trials that evaluated the effect of vitamin D supplementation on prostate specific antigen (PSA) response, mortality, and its possible side effects in participants with prostate cancer. The DerSimonian and Laird inverse-weighted random-effects model was used to pool the effect estimates. Twenty-two studies (16 before-after and 6 randomized controlled trials) were found and included in the meta-analysis. The an...
Source: Hormone and Metabolic Research - December 6, 2018 Category: Endocrinology Authors: Shahvazi, Simin Soltani, Sepideh Ahmadi, Seyed Mehdi de Souza, Russell J. Salehi-Abargouei, Amin Tags: Review Source Type: research

Hypercortisolism in Newly Diagnosed Type 2 Diabetes: A Prospective Study of 384 Newly Diagnosed Patients
Horm Metab Res DOI: 10.1055/a-0809-3647Cross-sectional studies in small and selected populations report a high prevalence of hypercortisolism in patients with type 2 diabetes (T2D), which could have therapeutic implications, if confirmed. We therefore estimated the prevalence of hypercortisolism in a large and unselected cohort of recently diagnosed T2D patients. Consecutive patients with recently diagnosed T2D first underwent an overnight dexamethasone (1 mg) suppression test (OD). Patients not suppressing serum cortisol ≤50 nmol/l proceeded with a 48-h low dose dexamethasone suppression test (LDDST) and ...
Source: Hormone and Metabolic Research - December 6, 2018 Category: Endocrinology Authors: Steffensen, Charlotte Dekkers, Olaf M. Lyhne, Johanne Pedersen, Bodil G. Rasmussen, Finn Rungby, J ørgen Poulsen, Per L øgstrup J ørgensen, Jens Otto Lunde Tags: Endocrine Care Source Type: research

Effect of Sodium Glucose Co-Transporter-2 Inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus
The objective was to explore the effect of Sodium Glucose Co-Transporter-2 Inhibition on the ARR in patients with type 2 diabetes mellitus (T2DM) who were prescribed a Sodium Glucose Co-Transporter-2 Inhibitor (SGLT-2i) as part of routine clinical care. The primary outcomes were intra-individual changes in aldosterone, renin and ARR. Participants were recruited at routine diabetes outpatient visits as part of a prospective longitudinal study. Eligible participants were prescribed standard doses of empagliflozin and sampled at baseline (pre-SGLT-2i) and at their next routine outpatient visit (post-SGLT-2i). After a mean of ...
Source: Hormone and Metabolic Research - December 6, 2018 Category: Endocrinology Authors: Griffin, Tom ás P Islam, Md Nahidul Blake, Liam Bell, Marcia Griffin, Matthew D. O ’Shea, Paula M. Tags: Endocrine Care Source Type: research

Autoimmune Thyroid Diseases
Horm Metab Res 2018; 50: 837-839 DOI: 10.1055/a-0799-5068 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 5, 2018 Category: Endocrinology Authors: Banga, J. Paul Schott, Matthias Tags: Editorial Source Type: research

Metabolic Syndrome is a Risk Factor for Post-Operative Adhesions: Need for Novel Treatment Strategies
Horm Metab Res DOI: 10.1055/a-0798-3931Metabolic syndrome is a group of disorders which include obesity, diabetes, dyslipidemias, and hypertension. This condition is rapidly increasing in an aging population. The rates of surgery in older patients is also growing and a wide range of operations including minimally invasive procedures is now available for this segment of the population. The number of patients suffering from postoperative adhesions is therefore correspondingly increasing. In addition to preventing and treating the metabolic disease itself, improved therapeutic strategies for the prevention of surgical adhesio...
Source: Hormone and Metabolic Research - November 29, 2018 Category: Endocrinology Authors: Pilpel, Yair Pines, Guy Birkenfeld, Andreas Bornstein, Stefan R. Miller, Rafael Tags: Review Source Type: research

Free IGF-1, Intact IGFBP-4, and PicoPAPP-A are Altered in Acute Myocardial Infarction Compared to Stable Coronary Artery Disease and Healthy Controls
Horm Metab Res DOI: 10.1055/a-0794-6163Insulin-like growth factor-1 (IGF-1) and its binding proteins have been implicated in the pathophysiology of coronary artery disease (CAD) and myocardial infarction (MI). We investigated components of the IGF-1 system in circulation at the time of acute MI and following reperfusion in relation to levels of stable CAD patients and controls. Patients with MI (MI Group, n=31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable CAD subjected to scheduled PCI (CAD Group, n=40) and controls with symptoms mimicking CAD without stenosis in angiography (...
Source: Hormone and Metabolic Research - November 29, 2018 Category: Endocrinology Authors: Anastasilakis, Athanasios D. Koulaxis, Dimitrios Upadhyay, Jagriti Pagkalidou, Eirini Kefala, Nikoleta Perakakis, Nikolaos Polyzos, Stergios A. Economou, Fotios Mantzoros, Christos S. Tags: Endocrine Care Source Type: research

Correction: Normocalcemic Primary Hyperparathyroidism: A Comparison with the Hypercalcemic Form in a Tertiary Referral Population
Horm Metab Res 2018; 50: e7-e7 DOI: 10.1055/a-0799-5387 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 29, 2018 Category: Endocrinology Authors: Pierreux, Jan Bravenboer, Bert Velkeniers, Brigitte Unuane, David Andreescu, Corina E. Vanhoeij, Marian Tags: Erratum Source Type: research