Predicitve Value of FDG Uptake in the Remaining Adrenal Gland Following Adrenalectomy for Adrenocortical Cancer
The objective of the study was to investigate a possible correlation between FDG-PET activity of the remaining adrenal gland and therapeutic response of mitotane treatment. This is a retrospective study enrolling patients from two German centers with operated ACC and minimal information on PET-CT scanning. Eighty-two ACC patients after adrenalectomy were included (66 treated with mitotane and 16 without medical therapy). FDG uptake of the contralateral adrenal gland, liver and mediastinum was analyzed from a total of 291 PET/CT scans (median 4 scans per patient) and correlated with c...
Source: Hormone and Metabolic Research - October 21, 2020 Category: Endocrinology Authors: Loewe, Ruben Rogowski-Lehmann, Natalie Pfluger, Thomas Reincke, Martin Hahner, Stefanie Bluemel, Christina Fassnacht, Martin Beuschlein, Felix Tags: Endocrine Care Source Type: research

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis
In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 13, 2020 Category: Endocrinology Authors: Isnuwardana, Ronny Bijukchhe, Sanjeev Thadanipon, Kunlawat Ingsathit, Atiporn Thakkinstian, Ammarin Tags: Endocrine Care Source Type: research

The Effect of Pituitary Gland Disorders on Glucose Metabolism: From Pathophysiology to Management
Horm Metab Res DOI: 10.1055/a-1258-8625This review aims to explore, present, and discuss disorders of glucose metabolism implicated in pituitary gland diseases, the appropriate interventions, as well as the therapeutic challenges that may arise. Pituitary pathologies may dysregulate glucose homeostasis, as both the excess and deficiency of various pituitary hormones can affect glucose metabolism. Increased circulating levels of growth hormone, glucocorticoids or prolactin have been shown to mainly provoke hyperglycemic states, while hypopituitarism can be associated with both hyperglycemia and hypoglycemia. Addressing the ...
Source: Hormone and Metabolic Research - October 12, 2020 Category: Endocrinology Authors: Sydney, Guy I. Michalakis, Konstantinos Nikas, Ilias P. Spartalis, Eleftherios Paschou, Stavroula A. Tags: Review Source Type: research

Blockade of CCL2/CCR2 Signaling Pathway Exerts Anti-Inflammatory Effects and Attenuates Gestational Diabetes Mellitus in a Genetic Mice Model
Horm Metab Res DOI: 10.1055/a-1250-8221The chemokine (C-C motif) ligand 2 (CCL2) and its receptor CCR2 are involved in gestational diabetes mellitus (GDM). The present study aims to explore the effects of CCL2 blocking on GDM. Serum CCL2, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were determined in GDM patients and healthy volunteers. C57BL/KsJdb/+mouse was used as the GDM model and CCL2 antibody (αCCL2) was applied. Flow cytometry was applied to determine the frequency of macrophages. Quantitative reverse transcription PCR (RT-qPCR) and western blot were determined to detect the mRNA and protein ex...
Source: Hormone and Metabolic Research - October 5, 2020 Category: Endocrinology Authors: Qi, Xinying Xing, Yanping Wang, Xuezhen Tags: Endocrine Research Source Type: research

Recombinant Human Thyrotropin-Stimulated Radioiodine Therapy in Patients with Multinodular Goiters: A Meta-Analysis of Randomized Controlled Trials
Horm Metab Res DOI: 10.1055/a-1240-5058A potential reduction of goiter volume (GV) of recombinant human thyrotropin (rhTSH) on multinodular goiters (MNG) was previously reported but controversial. Hence we conducted a meta-analysis to estimate the effect of rhTSH-stimulated radioiodine therapy in patients with MNG. PubMed, Cochrane, CNKI, VIP, and Wanfang databases were searched. Mean difference (MD) and odds ratios with 95% confidence intervals (95% CI) were derived by using an inverse variance random-effects model and fixed-effects model, respectively. Six studies (n=237) were involved ...
Source: Hormone and Metabolic Research - September 21, 2020 Category: Endocrinology Authors: Xu, Chunmei Wang, Ping Miao, Huikai Xie, Tianyue Zhou, Xiaojun Zhang, Qian Jiang, Shan Zhang, Rui Liao, Lin Dong, Jianjun Tags: Endocrine Care Source Type: research

Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence
Horm Metab Res DOI: 10.1055/a-1243-5462COVID-19 is a global pandemic with high mortality in vulnerable groups. Given the current lack of definitive treatment or vaccine that significantly reduces mortality rate, governments, researchers and healthcare providers are racing to find possible solutions to the crisis. Vitamin D and its analogues have been previously studied for their non-skeletal benefits. In particular, questions regarding their role in the modulation of immunity have re-surfaced, in view of possible epidemiological links observed between COVID-19 and vitamin D levels in sele...
Source: Hormone and Metabolic Research - September 16, 2020 Category: Endocrinology Authors: Hoong, Caroline Wei Shan Huilin, Koh Cho, Sanda Aravamudan, Veeraraghavan Meyyur Lin, Jaime Hui Xian Tags: Review Source Type: research

Insights Into the Controversial Aspects of Adiponectin in Cardiometabolic Disorders
Horm Metab Res DOI: 10.1055/a-1239-4349In 2016, the World Health Organization estimated that more than 1.9 billion adults were overweight or obese. This impressive number shows that weight excess is pandemic. Overweight and obesity are closely associated with a high risk of comorbidities, such as insulin resistance and its most important outcomes, including metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. Adiponectin has emerged as a salutary adipocytokine, with insulin-sensitizing, anti-inflammatory, and cardiovascular protective properties. However, under metabo...
Source: Hormone and Metabolic Research - September 13, 2020 Category: Endocrinology Authors: Francischetti, Emilio Antonio Dezonne, R ômulo Sperduto Pereira, Cl áudia Maria de Moraes Martins, Cyro Jos é Celoria, Bruno Miguel Jorge de Oliveira, Patr ícia Aguiar Cardoso de Abreu, Virg ínia Genelhu Tags: Review Source Type: research

Correction: Associations of Thyroid Hormones and Resting Heart Rate in Patients Referred to Coronary Angiography
Horm Metab Res DOI: 10.1055/a-1260-4769 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 13, 2020 Category: Endocrinology Authors: Steinberger, Eva Pilz, Stefan Trummer, Christian Theiler-Schwetz, Verena Reichhartinger, Markus Benninger, Thomas Pandis, Marlene Malle, Oliver Keppel, Martin H. Verheyen, Nicolas Gr übler, Martin R. Voelkl, Jakob Meinitzer, Andreas M ärz, Winfried Tags: Erratum Source Type: research

COVID-19 in Children and Adolescents with Endocrine Conditions
Horm Metab Res DOI: 10.1055/a-1227-6635The rapid spread of coronavirus disease (COVID-19) worldwide justifies global effort to combat the disease but also the need to review effective preventive strategies and medical management for potentially high-risk populations during the pandemic. Data regarding the COVID-19 manifestations in adults with underlying endocrine conditions, especially diabetes mellitus, are increasingly emerging. Albeit children and adolescents are considered to be affected in a milder manner, paucity of information regarding COVID-19 in children who suffer from endocri...
Source: Hormone and Metabolic Research - September 7, 2020 Category: Endocrinology Authors: Kostopoulou, Eirini G üemes, Maria Shah, Pratik Tags: Review Source Type: research

Associations of Thyroid Hormones and Resting Heart Rate in Patients Referred to Coronary Angiography
Horm Metab Res DOI: 10.1055/a-1232-7292Resting heart rate (RHR) is associated with increased risk of cardiovascular morbidity and mortality. Thyroid hormones exert several effects on the cardiovascular system, but the relation between thyroid function and RHR remains to be further established. We evaluated whether measures of thyroid hormone status are associated with RHR in patients referred to coronary angiography. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxin (FT4), and RHR were determined in 2795 participants of the Ludwigshafen Risk and Cardiovascular ...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Steinberger, Eva Pilz, Stefan Trummer, Christian Theiler-Schwetz, Verena Reichhartinge, Markus Benninger, Thomas Pandis, Marlene Malle, Oliver Keppel, Martin H. Verheyen, Nicolas Gr übler, Martin R. Voelkl, Jakob Meinitzer, Andreas M ärz, Winfried Tags: Endocrine Care Source Type: research

Associations of the LPL S447X and Hind III Polymorphism with Type 2 Diabetes Mellitus Risk: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1229-1604The present study was aimed to evaluate the association of lipoprotein lipase (LPL) gene (S447X and Hind III) polymorphisms and T2DM. Relevant studies were identified through systematic search PubMed, Cochrane Library, Embase, Wanfang, CNKI databases. A total of 22 studies (8 studies for LPL S447X and 14 studies for Hind III) were included. The results showed that the LPL S447X polymorphism was associated with the low risk of T2DM under dominant and allelic genetic models. Subgroup analysis by ethnicity showed that the LPL S447X polymorphism was asso...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Liu, Na Sang, Yan Chen, Shengzhi Liu, Xiaoming Tags: Endocrine Care Source Type: research

Thyroglobulin Antibodies as a Prognostic Factor in Papillary Thyroid Carcinoma Patients with Indeterminate Response After Initial Therapy
This study evaluated the outcomes of PTC patients with indeterminate response after initial therapy. It was further determined whether the indeterminate findings predicted outcomes more precisely. Patients were further classified into 3 groups based on risk of structural persistence/recurrence: Tg group: detectable thyroglobulin, negative antithyroglobulin antibody, regardless nonspecific imaging findings; TgAb group: positive antithyroglobulin antibody, regardless thyroglobulin levels and nonspecific imaging findings, and Image group: nonspecific findings on neck ultrasonography or...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Landenberger, Giullia Menuci Chianca de Souza Salerno, Marianna Lins Golbert, Lenara de Souza Meyer, Erika Laurini Tags: Endocrine Care Source Type: research

Idiopathic Hypoparathyroidism: Still a Diagnostic Conundrum – A Tertiary Centre Experience
Horm Metab Res DOI: 10.1055/a-1228-8199Idiopathic hypoparathyroidism leads to hypocalcemia and hyperphosphatasemia and usually has a genetic aetiology. The variable but often subtle signs and symptoms usually lead to a misdiagnosis of hypoparathyroidism. Case records of 32 patients of idiopathic hypoparathyroidism admitted over a period of five years were analysed. There was a lag period of 5.94 years from the onset of symptoms to the diagnosis. Carpopedal spasm was the most common indication for admission to the hospital. Trivial symptoms such as fatigue (84%) and paresthesia (62.5%) wer...
Source: Hormone and Metabolic Research - September 3, 2020 Category: Endocrinology Authors: Jain, Rujul Singh, S. K. Agrawal, N. K. Tags: Endocrine Care Source Type: research

Five Reasons for the Failure to Diagnose Aldosterone Excess in Hypertension
Horm Metab Res DOI: 10.1055/a-1236-4869Primary hyperaldosteronism (PA) is a well-known cause of hypertension although its exact prevalence amongst patients with apparent essential hypertension has been a matter of debate. A number of recent studies have suggested that mild forms of PA may be relatively common taking into consideration factors that were previously either overestimated or ignored when developing diagnostic tests of PA and when applying these tests into normotensive individuals. The performance characteristics and diagnostic accuracy of such tests are substantially increased...
Source: Hormone and Metabolic Research - September 2, 2020 Category: Endocrinology Authors: Piaditis, George P. Kaltsas, Gregory Markou, Athina Chrousos, George P. Tags: Review Source Type: research

Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors
Horm Metab Res 2020; 52: 607-613 DOI: 10.1055/a-1212-8803Lack of routine fresh or frozen tissue is a barrier to widespread transcriptomic analysis of adrenal cortical tumors and an impediment to translational research in endocrinology and endocrine oncology. Our group has previously pioneered the use of targeted amplicon-based next-generation sequencing for archival formalin-fixed paraffin-embedded (FFPE) adrenal tissue specimens to characterize the spectrum of somatic mutations in various forms of primary aldosteronism. Herein, we developed and validated a novel 194-amplicon targeted next-gen...
Source: Hormone and Metabolic Research - August 12, 2020 Category: Endocrinology Authors: Plaska, Samuel W. Liu, Chia-Jen Lim, Jung Soo Rege, Juilee Bick, Nolan R. Lerario, Antonio M. Hammer, Gary D. Giordano, Thomas J. Else, Tobias Tomlins, Scott A. Rainey, William E. Udager, Aaron M. Tags: Endocrine Research Source Type: research

A Century After the Description of “Hormones”, Our Golden Jubilee Celebration Goes on with What is New in Endocrine Oncology: And a Lot is New!
Horm Metab Res 2020; 52: 551-552 DOI: 10.1055/a-1217-1529About 3000 thousand years ago Marcus Aurelius said: “Time is a sort of river of passing events, and strong is its current; no sooner is a thing brought to sight than it is swept by and another takes its place, and this too will be swept away…” 1. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 12, 2020 Category: Endocrinology Authors: Stratakis, Constantine A. Tags: Editorial Source Type: research

Severe Hypocalcemia and Transient Hypoparathyroidism After Hyperthermic Intraperitoneal Chemotherapy
Horm Metab Res DOI: 10.1055/a-1220-6971Dear Editors,Hypocalcemia is not unusual in patients hospitalized for critical illness and has also been described after general surgery in addition to head and neck surgical procedures 1 2 3. Hypocalcemic events commonly occur in the setting of massive blood transfusion, albumin deficiency, vitamin D deficiency, and/or hypomagnesemia. In the absence of these factors, only slight decreases in calcium levels within the normal range have been reported during surgical procedures 1. Cytoreductive surgery with hyperthermic intraperitoneal chemothera...
Source: Hormone and Metabolic Research - August 6, 2020 Category: Endocrinology Authors: Tharmalingam, Senthuran Reddy, Sanjay Sharda, Pankaj Koch, Christian A. Tags: Letter to the Editor Source Type: research

No Independent Association of Circulating Fetuin-A with Insulin Sensitivity in Young Women
Horm Metab Res DOI: 10.1055/a-1216-4405Animal data link high circulating fetuin-A to low insulin sensitivity and observational studies identify the hepatokine as a marker of future incident type 2 diabetes mellitus in humans. However, a recent, well-powered Mendelian randomization study finds no causal role. We therefore tested in a deeply-phenotyped human cohort if circulating fetuin-A correlates independently with insulin sensitivity and how it relates to the metabolic syndrome and ectopic fat deposition. We analyzed data from 290 young women with and without recent gestational diabetes...
Source: Hormone and Metabolic Research - August 5, 2020 Category: Endocrinology Authors: Reif, Sabrina Moschko, Sarah Gar, Christina Ferrari, Uta Hesse, Nina Sommer, Nora N. Sei ßler, Jochen Lechner, Andreas Tags: Endocrine Care Source Type: research

Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by Somatolactotroph Tumours
Horm Metab Res DOI: 10.1055/a-1207-1132The aim of this study is to assess differences in patient characteristics, tumour characteristics and hormone levels between acromegalic patients with and without hyperprolactinemia. 44 patients of the University Hospital of Brussels, Belgium with acromegaly who were diagnosed between January 2007 and July 2018 were included in this study. Nineteen patients were classified in the hyperprolactinemia group and 25 patients were classified in the normoprolactinemia group. No significant differences between acromegalic patients with and without hyp...
Source: Hormone and Metabolic Research - August 4, 2020 Category: Endocrinology Authors: Van Laethem, Delphine Michotte, Alex Cools, Wilfried Velkeniers, Brigitte Unuane, David Andreescu, C. E. Bravenboer, Bert Tags: Endocrine Care Source Type: research

Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism
Horm Metab Res DOI: 10.1055/a-1177-6814Adult patients with a dysfunctional ether-a-go-go 2 (hERG2) protein, which is encoded by the KCNH6 gene, present with hyperinsulinemia and hyperglycemia. However, the mechanism of KCNH6 in glucose metabolism disorders has not been clearly defined. It has been proposed that sustained endoplasmic reticulum (ER) stress is closely concerned with hepatic insulin resistance and inflammation. Here, we demonstrate that Kcnh6 knockout (KO) mice had impaired glucose tolerance and increased levels of hepatic apoptosis, in addition to displaying an increased ins...
Source: Hormone and Metabolic Research - August 3, 2020 Category: Endocrinology Authors: Lu, Jing Shen, Han Li, Qi Xiong, Feng-Ran Yuan, Ming-Xia Yang, Jin-Kui Tags: Endocrine Research Source Type: research

Reappraising the Diagnostic Accuracy of Post-Treatment Whole-Body Scans for Differentiated Thyroid Carcinoma
Horm Metab Res DOI: 10.1055/a-1212-8594Initial treatment for differentiated thyroid carcinoma (DTC) often consists of surgery and the administration of radioiodine. In this context, post-treatment Whole-Body Scans (ptWBS) are currently recommended, but data on its diagnostic accuracy are rare. The aim of the study was to evaluate the performance of ptWBS for distant metastasis in DTC patients. We included DTC patients who received radioiodine and underwent ptWBS between 2009–2015. The medical data were independently reviewed by two specialists to evaluate the concordance of positive...
Source: Hormone and Metabolic Research - August 3, 2020 Category: Endocrinology Authors: Nava, Carla Fernanda Scheffel, Rafael Selbach Zanella, Andr é Borsatto Zelmanovitz, Flavio Maia, Ana Luiza Dora, Jose Miguel Tags: Endocrine Care Source Type: research

Is There Really an Association of High Circulating Adiponectin Concentration and Mortality or Morbidity Risk in Stable Coronary Artery Disease?
In conclusion, the observed inverse association between adiponectin concentrations and mortality risk seems to be attributable to concomitantly increased BNP, rather than high adiponectin being a causal factor. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 2, 2020 Category: Endocrinology Authors: Mayer, Otto Seidlerov á, Jitka Bruthans, Jan Gel žinský, Julius Rycheck á, Martina Mate řánková, Markéta Karnosov á, Petra Wohlfahrt, Peter C ífková, Renata Filipovsk ý, Jan Tags: Endocrine Care Source Type: research

Endogenous NUCB2/Nesfatin-1 Regulates Energy Homeostasis Under Physiological Conditions in Male Rats
Horm Metab Res DOI: 10.1055/a-1196-2059Nesfatin-1 is the proteolytic cleavage product of Nucleobindin 2, which is expressed both in a number of brain nuclei (e. g., the paraventricular nucleus of the hypothalamus) and peripheral tissues. While Nucleobindin 2 acts as a calcium binding protein, nesfatin-1 was shown to affect energy homeostasis upon central nervous administration by decreasing food intake and increasing thermogenesis. In turn, Nucleobindin 2 mRNA expression is downregulated in starvation and upregulated in the satiated state. Still, knowledge about the physiological r...
Source: Hormone and Metabolic Research - July 27, 2020 Category: Endocrinology Authors: Wilz, Anna-Maria Wernecke, Kerstin Appel, Lena Kahrs, Johanna Dore, Riccardo J öhren, Olaf Lehnert, Hendrik Schulz, Carla Tags: Endocrine Research Source Type: research

Unacylated Ghrelin Regulates Glucose-Sensitive Neurons Activity and Glycolipid Metabolism via Orexin-A Neurons in the Lateral Hypothalamic Area
The objective of the study was to investigate the regulatory actions of unacylated ghrelin (UAG) on glucose-sensitive (GS) neurons and glycolipid metabolism in the lateral hypothalamus area (LHA) and its involvement with orexin-A-immunopositive neurons. The effects of UAG administered into the LHA on GS neurons discharges and glycolipid metabolism were detected by single neuron discharge recording, biochemical index analysis and quantitative real-time PCR; the level of c-fos protein in orexin-A-immunopositive neurons was observed using immunofluorescence staining. UAG microin...
Source: Hormone and Metabolic Research - July 26, 2020 Category: Endocrinology Authors: Su, Manqing Yan, Meixing Yao, Jiatong Fang, Yanpeng Jin, Hong Gong, Yanling Tags: Endocrine Research Source Type: research

Role of the KCNJ Gene Variants in the Clinical Outcome of Type 1 Diabetes
Horm Metab Res DOI: 10.1055/a-1204-5443Diabetes is considered as a disease with a wide and continuous clinical spectrum, ranging from Type 1 (T1D) and Type 2 Diabetes (T2D) with complex multifactorial causes. In the last years, particular attention has been focused on the predictive value and therapeutic potential of single nucleotide polymorphisms (SNPs). SNPs can alter the seed-sequence in miRNA’s loci and miRNA target sites causing changes in the structure and influencing the binding function. Only few studies have investigated the clinical influence of SNPs, in particular...
Source: Hormone and Metabolic Research - July 20, 2020 Category: Endocrinology Authors: Blasetti, Annalisa Castorani, Valeria Comegna, Laura Franchini, Simone Prezioso, Giovanni Provenzano, Martina Di Giulio, Concetta Iannucci, Daniela Matonti, Lorena Tumini, Stefano Chiarelli, Francesco Stuppia, Liborio Tags: Endocrine Care Source Type: research

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1199-2633Increased plasma homocysteine (Hcy) levels have been widely documented in patients with overt hypothyroidism; however, the significance of Hcy level changes in patients with subclinical hypothyroidism (SCH) remains controversial. The aim of this meta-analysis was to determine the Hcy status in patients with SCH compared with euthyroid subjects. We searched PubMed, Embase, and Cochrane Library databases prior to December 2019 to identify eligible studies and assessed the quality of selected studies using the Newcastle-Ottawa Quality Assessment ...
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Zhang, Shou-Fa Li, Li-Zhi Zhang, Wei Guo, Jin-Rong Liu, Fang-Fang Ma, Kai Chen, Shao-Hua Zhang, Ya-Qing Tags: Review Source Type: research

Inflammatory Cell Infiltration of Adrenals in COVID-19
Horm Metab Res DOI: 10.1055/a-1191-8094Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November–December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is e...
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Zinserling, Vsevolod A. Semenova, Natalya Yu. Markov, Alexander G. Rybalchenko, Oksana V. Wang, Jun Rodionov, Roman N. Bornstein, Stefan R. Tags: Immediate Interest Source Type: research

Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice
Horm Metab Res DOI: 10.1055/a-1199-2257The C57BL/6J (B6J) mouse strain has been widely used as a control strain for the study of metabolic diseases and diet induced obesity (DIO). B6J mice carry a spontaneous deletion mutation in the nicotinamide nucleotide transhydrogenase (Nnt) gene eliminating exons 7–11, resulting in expression of a truncated form of Nnt, an enzyme that pumps protons across the inner mitochondrial membrane. It has been proposed that this mutation in B6J mice is associated with epigonadal fat mass and altered sensitivity to diet induced obesity. To define ...
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Kunath, Anne Heiker, John T. Kern, Matthias Kosacka, Joanna Flehmig, Gesine Stumvoll, Michael Kovacs, Peter Bl üher, Matthias Kl öting, Nora Tags: Endocrine Research Source Type: research

Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?
Horm Metab Res DOI: 10.1055/a-1199-2378The aim of the study was to test the correlation of serum levels of asymmetric dimethylarginine (ADMA), endothelin 1 (ET-1), N-terminal brain natriuretic pro-peptide (NT-proBNP), and placental growth factor (PIGF-1) with estimated cardiovascular (CV) risk. The study group was composed of 102 women and 67 men with type 2 diabetes, having their glycemic and metabolic parameters assessed. All were on oral antidiabetic drugs. Serum levels of NT-proBNP and PIGF-1 were measured by electro-hemi-luminescence on an Elecsys 2010 analyzer. Enzymatic immu...
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Markova, Aleksandra Boyanov, Mihail Bakalov, Deniz Kundurdjiev, Atanas Tsakova, Adelina Tags: Endocrine Care Source Type: research

Prediction of Hypoglycemia During Admission of Non-Critically Ill Patients: Results from the MENU Study
The objective of the work was to study admission parameters associated with an increased incidence of hypoglycemia during hospitalization of non-critically ill patients. Included in this cross-sectional study were patients admitted to internal medicine units. The Nutritional Risk Screening 2002 (NRS2002) was used for nutritional screening. Data recorded included admission serum albumin (ASA) and all glucose measurements obtained by the institutional blood glucose monitoring system. Neither of these are included in the NRS2002 metrics. Hypoalbuminemia was defined as ASA
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Khanimov, Israel Ditch, Meital Adler, Henriett Giryes, Sami Felner Burg, Noa Boaz, Mona Leibovitz, Eyal Tags: Endocrine Care Source Type: research

Central Diabetes Insipidus Caused by Arginine Vasopressin Gene Mutation: Report of a Novel Mutation and Review of Literature
In this study, we describe a new arginine vasopressin (AVP) gene mutation in an ethnic German family with FNDI and provide an overview of disease-associated AVP-gene mutations that are already described in literature. Three members of a German family with neurohypophyseal diabetes insipidus were studied. Isolated DNA from peripheral blood samples was used for mutation analysis by sequencing the whole coding region of AVP-NPII gene. Furthermore, we searched the electronic databases MEDLINE (Pubmed) as well as HGMD, LOVD-ClinVar, db-SNP and genomAD in order to compare our cases...
Source: Hormone and Metabolic Research - July 5, 2020 Category: Endocrinology Authors: Feldkamp, Lara L.I. Kaminsky, Elke Kienitz, Tina Quinkler, Marcus Tags: Endocrine Care Source Type: research

Correction: The Relationship Between the Impairment of Endothelial Function and Thyroid Antibodies in Hashimoto ’s Thyroiditis Patients with Euthyroidism
Horm Metab Res DOI: 10.1055/a-1204-0011 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - June 29, 2020 Category: Endocrinology Authors: Hu, Yanjin Yao, Zhi Wang, Guang Tags: Erratum Source Type: research

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?
Horm Metab Res DOI: 10.1055/a-1182-2016The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic affects people around the world. However, there have been striking differences in the number of infected individuals and deaths in different countries. Particularly, within Central Europe in countries that are similar in ethnicity, age, and medical standards and have performed similar steps of containment, such differences in mortality rates remain inexplicable. We suggest to consider and explore environmental factors to explain these intriguing variations. Countries lik...
Source: Hormone and Metabolic Research - June 28, 2020 Category: Endocrinology Authors: Bornstein, Stefan R. Voit-Bak, Karin Schmidt, Dieter Morawietz, Henning Bornstein, Alexander Benjamin Balanzew, Waldimir Julius, Ulrich Rodionov, Roman N. Biener, Anne Maria Wang, Jun Schulte, Klaus-Martin Krebs, Peter Vollmer, G ünter Straube, R. Tags: Hypothesis Source Type: research

Correlation Between Serum TSH Levels Within Normal Range and Serum Lipid Profile
Horm Metab Res DOI: 10.1055/a-1191-7953The aim of the work was to investigate the correlation between serum TSH (thyrotropin) levels within normal range and serum lipids. A total of 1962 subjects with normal thyroid function were enrolled. The subjects were divided into four groups according to the quartiles of serum normal TSH levels, [Q1 (0.27–1.68) mIU/l, Q2 (1.69–2.35) mIU/l, Q3 (2.36–3.07) mIU/l, and Q4 (3.08–4.20) mIU/l]. The effect of serum normal TSH levels on serum lipid profiles of different age or gender was analyzed. The total cholesterol (TC), tr...
Source: Hormone and Metabolic Research - June 22, 2020 Category: Endocrinology Authors: Luxia, Liu Jingfang, Liu Songbo, Fu Xulei, Tang Lihua, Ma Weiming, Sun Ying, Niu Gaojing, Jing Qianglong, Niu Yujuan, Li Dan, Wu Fang, Yang Huiping, Guo Pei, Song Tags: Endocrine Care Source Type: research

Thyroxine Treatment During the Perinatal Stage Prevents the Alterations in the ObRb-STAT3 Leptin Signaling Pathway Caused by Congenital Hypothyroidism
In conclusion, thyroxine treatment during the critical perinatal stage for metabolic programming prevents congenital hypothyroidism-caused metabolic syndrome and hypothalamic leptin resistance. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - June 18, 2020 Category: Endocrinology Authors: Tapia-Mart ínez, Jorge Cano-Europa, Edgar Blas-Valdivia, Vanessa Franco-Col ín, Margarita Tags: Endocrine Research Source Type: research

Effects and Safety of Sitagliptin in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1186-0841Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. However, the treatment is limited. The aim of this meta-analysis was to evaluate the effects and safety of sitagliptin, a selective inhibitor of dipeptidyl peptidase-4 (DPP-4I), in treating NAFLD. Studies were sourced from electronic databases including PubMed, CENTRAL (Cochrane Controlled Trials Register), Embase, Medline, Web of Science, Clinical Trials, and CNKI to identify all randomized controlled clinical trials (RCTs) and non-RCTs in adult pa...
Source: Hormone and Metabolic Research - June 18, 2020 Category: Endocrinology Authors: Zhang, Yuhan Cai, Tian Zhao, Junyu Guo, Congcong Yao, Jinming Gao, Peng Dong, Jianjun Liao, Lin Tags: Endocrine Care Source Type: research

Correction: Autonomic Dysfunction is Associated with Increased Cardiometabolic Risk in Patients with Childhood-Onset Craniopharyngioma
Horm Metab Res DOI: 10.1055/a-1192-5447 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - June 15, 2020 Category: Endocrinology Authors: Jung, Hae Woon Kim, Hwa Young Kim, Ji Young Cheon, Jung-Eun Kim, In-One Kim, Seung-Ki Shin, Choong Ho Yang, Sei Won Lee, Young Ah Tags: Erratum Source Type: research

Progress in Primary Aldosteronism 2019: New Players on the Block?
Horm Metab Res 2020; 52: 345-346 DOI: 10.1055/a-1156-9926Primary aldosteronism (PA) is characterized by hypertension caused by inappropriately high adrenal aldosterone secretion, consecutively low plasma renin, and an elevated aldosterone to renin ratio. It is nowadays the universally accepted main cause of endocrine hypertension. According to the most recent epidemiological data, PA is present in 5.8% of unselected hypertensives in primary care, 6–12% of hypertensives treated in hypertension centers, and up to 30% in subjects with resistant hypertension 1. Despite this high prevalence, ...
Source: Hormone and Metabolic Research - June 15, 2020 Category: Endocrinology Authors: Reincke, Martin Beuschlein, Felix Williams, Tracy Ann Tags: Editorial Source Type: research

Zinc- α2-Glycoprotein Knockout Influenced Genes Expression Profile in Adipose Tissue and Decreased the Lipid Mobilizing After Dexamethasone Treatment in Mice
In conclusion, ZAG knockout can affect the gene expression profile of adipose tissue, reduce elevated TG and NEFA levels in plasma, and alter lipid metabolism under DEX treatment. These findings provide new insights into the mechanism of lipid metabolic disorders in response to stress. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - June 14, 2020 Category: Endocrinology Authors: Zhang, Wenge Qiao, Yu Qi, Fulei Shen, Qingyi Zhao, Ruqian Yang, Xiaojing Tags: Endocrine Research Source Type: research

Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation
This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 “G” (pc=0.031), rs1544410 “G” (pc=0.027) and CYP2R1 rs10741657 “A&rd...
Source: Hormone and Metabolic Research - June 14, 2020 Category: Endocrinology Authors: Klahold, Edith Penna-Martinez, Marissa Bruns, Franziska Seidl, Christian Wicker, Sabine Badenhoop, Klaus Tags: Endocrine Care Source Type: research

The Relationship Between the Impairment of Endothelial Function and Thyroid Antibodies in Hashimoto ’s Thyroiditis Patients with Euthyroidism
Horm Metab Res DOI: 10.1055/a-1178-5882Endothelial dysfunction is the important early step in the development of atherosclerosis. Hypothyroidism caused by Hashimoto’s thyroiditis and other thyroid disease is one of the risk factors of endothelial dysfunction. The present study tried to investigate the endothelial function and its associated factors in Hashimoto thyroiditis with euthyroidism. A total of 95 newly diagnosed Hashimoto’s thyroiditis patients with euthyroidism and 45 healthy controls were studied. Hashimoto’s patients were divided into 3 subgroups namely, sing...
Source: Hormone and Metabolic Research - June 14, 2020 Category: Endocrinology Authors: Hu, Yanjin Yao, Zhi Wang, Guang Tags: Endocrine Care Source Type: research

Pancreatic Neuroendocrine Neoplasm Associated with a Familial MAX Deletion
Horm Metab Res DOI: 10.1055/a-1186-0790Most pancreatic neuroendocrine neoplasms (pNEN) occur sporadically but they can also occur as part of multiple endocrine neoplasia type 1 (MEN1). MAX was originally described as an inherited pheochromocytoma-paraganglioma risk gene, but also has recently been implicated in pituitary tumorigenesis. Here we describe the first case of a pNEN associated with an inherited MAX gene deletion in a family with endocrine tumors. The patient was a male carrier of an intragenic exon 3 deletion inherited from his father who had recurrent pheochromocytomas...
Source: Hormone and Metabolic Research - June 9, 2020 Category: Endocrinology Authors: Petignot, Sandrine Daly, Adrian F. Castermans, Emilie Korpershoek, Esther Scagnol, Ir ène Beckers, Pablo Dideberg, Vinciane Rohmer, Vincent Bours, Vincent Beckers, Albert Tags: Endocrine Care Source Type: research

Endocrine Conditions and COVID-19
Horm Metab Res DOI: 10.1055/a-1172-1352COVID-19 was declared a global pandemic by the WHO and has affected millions of patients around the world. COVID-19 disproportionately affects persons with endocrine conditions, thus putting them at an increased risk for severe disease. We discuss the mechanisms that place persons with endocrine conditions at an additional risk for severe COVID-19 and review the evidence. We also suggest precautions and management of endocrine conditions in the setting of global curfews being imposed and offer practical tips for uninterrupted endocrine care. [...
Source: Hormone and Metabolic Research - June 7, 2020 Category: Endocrinology Authors: Shekhar, Skand Wurth, Rachel Kamilaris, Crystal D. C. Eisenhofer, Graeme Barrera, Francisco J. Hajdenberg, Michelle Tonleu, Joselyne Hall, Janet E. Schiffrin, Ernesto L. Porter, Forbes Stratakis , Constantine A. Hannah-Shmouni, Fady Tags: Review Source Type: research

Autonomic Dysfunction is Associated with Increased Cardiometabolic Risk in Patients with Childhood-Onset Craniopharyngioma
Horm Metab Res DOI: 10.1055/a-1169-0307Patients with craniopharyngioma are susceptible to autonomic dysfunction as a result of hypothalamic damage. We evaluated indices of heart rate variability (HRV) in patients with childhood-onset craniopharyngioma to investigate autonomic function and its relationship with components of the metabolic syndrome (MetS). This cross-sectional, case-only study included 53 patients (10–30 years of age). We measured the standard deviation of all normal R-R intervals (SDNN) and total power indicating overall HRV, the root-mean square of the differ...
Source: Hormone and Metabolic Research - June 7, 2020 Category: Endocrinology Authors: Jung, Hae Woon Kim, Hwa Young Kim, Ji Young Cheon, Jung-Eun Kim, In-One Kim, Seung-Ki Shin, Choong Ho Yang, Sei Won Lee, Young Ah Tags: Endocrine Care Source Type: research

Stabilization of BMIz Score is Associated with a Decrease in Visceral Fat in Children with Obesity
The objective of the work was to study changes in visceral fat, cardiovascular fitness (CVF), and metabolic health over 6 months in children with stable/decreased-BMIz vs. increased-BMIz. Ninety children with obesity, referred for lifestyle intervention were studied (mean age 11±3.1 years, 50% girls, 22% Hispanic). Assessment included abdominal and total fat by dual X-ray absorptiometry (DXA), sub-maximal VO2 for CVF, anthropometrics, and fasting insulin, glucose, HDL-C, triglycerides, AST and ALT at 0 and 6 months. Sixty-three children (70%) showed a stable/decrease in BMIz over 6 months. There was no significant c...
Source: Hormone and Metabolic Research - June 1, 2020 Category: Endocrinology Authors: Naik, Yashoda Allen, David B. Eickhoff, Jens Carrel, Aaron L. Tags: Endocrine Care Source Type: research

Correction: Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study
Horm Metab Res DOI: 10.1055/a-1175-6502 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 18, 2020 Category: Endocrinology Authors: Tian, Zhenhua Su, Yu Zhang, Meijie Zhang, Xiujuan Guan, Qingbo Tags: Erratum Source Type: research

Correction: Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study
Horm Metab Res DOI: 10.1055/a-1175-6502 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 18, 2020 Category: Endocrinology Authors: Tian, Zhenhua Su, Yu Zhang, Meijie Zhang, Xiujuan Guan, Qingbo Tags: Erratum Source Type: research

The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review
Horm Metab Res DOI: 10.1055/a-1160-9902This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. ...
Source: Hormone and Metabolic Research - May 17, 2020 Category: Endocrinology Authors: Williams, Ashley Babu, Jeganathan Ramesh Wadsworth, Danielle D. Burnett, Donna Geetha, Thangiah Tags: Review Source Type: research

The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status
Horm Metab Res DOI: 10.1055/a-1157-0511Primary aldosteronism (PA) was reported to frequently harbor not only cardiovascular diseases but also some metabolic disorders including secondary calcium metabolic diseases. Recently, the potential association between aldosterone producing cells and systemic calcium metabolism has been proposed. For instance, PA is frequently associated with hypercalciuria or hypocalcemia, which subsequently stimulates parathyroid hormone (PTH) secretion. This altered calcium metabolism in PA patients could frequently result in secondary osteoporosis and fra...
Source: Hormone and Metabolic Research - May 12, 2020 Category: Endocrinology Authors: Gao, Xin Yamazaki, Yuto Tezuka, Yuta Omata, Kei Ono, Yoshikiyo Morimoto, Ryo Nakamura, Yasuhiro Satoh, Fumitoshi Sasano, Hironobu Tags: Review Source Type: research

The Impact of Glucocorticoid Co-Secretion in Primary Aldosteronism on Thyroid Autoantibody Titers During the Course of Disease
Horm Metab Res DOI: 10.1055/a-1164-1944Excess aldosterone is associated with the increased risk of cardio-/cerebrovascular events as well as metabolic comorbidities not only due to its hypertensive effect but also due to its proinflammatory action. Autonomous cortisol secretion (ACS) in the setting of primary aldosteronism (PA) is known to worsen cardiovascular outcome and potentially exhibit immunosuppressive effects. The aim of this study was to determine the impact of ACS status in patients with PA on kinetics of thyroid autoantibodies (anti-TPO, anti-TG) pre and post therapy in...
Source: Hormone and Metabolic Research - May 12, 2020 Category: Endocrinology Authors: Handgriff, Laura Adolf, Christian Heinrich, Daniel A. Braun, Leah Nirschl, Nina Sturm, Lisa Ladurner, Roland Ricke, Jens Seidensticker, Max Bidlingmaier, Martin Reincke, Martin Tags: Endocrine Research Source Type: research