Stabilization of BMIz Score is Associated with a Decrease in Visceral Fat in Children with Obesity
The objective of the work was to study changes in visceral fat, cardiovascular fitness (CVF), and metabolic health over 6 months in children with stable/decreased-BMIz vs. increased-BMIz. Ninety children with obesity, referred for lifestyle intervention were studied (mean age 11±3.1 years, 50% girls, 22% Hispanic). Assessment included abdominal and total fat by dual X-ray absorptiometry (DXA), sub-maximal VO2 for CVF, anthropometrics, and fasting insulin, glucose, HDL-C, triglycerides, AST and ALT at 0 and 6 months. Sixty-three children (70%) showed a stable/decrease in BMIz over 6 months. There was no significant c...
Source: Hormone and Metabolic Research - June 2, 2020 Category: Endocrinology Authors: Naik, Yashoda Allen, David B. Eickhoff, Jens Carrel, Aaron L. Tags: Endocrine Care Source Type: research

Correction: Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study
Horm Metab Res DOI: 10.1055/a-1175-6502 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 19, 2020 Category: Endocrinology Authors: Tian, Zhenhua Su, Yu Zhang, Meijie Zhang, Xiujuan Guan, Qingbo Tags: Erratum Source Type: research

The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review
Horm Metab Res DOI: 10.1055/a-1160-9902This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. ...
Source: Hormone and Metabolic Research - May 18, 2020 Category: Endocrinology Authors: Williams, Ashley Babu, Jeganathan Ramesh Wadsworth, Danielle D. Burnett, Donna Geetha, Thangiah Tags: Review Source Type: research

The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status
Horm Metab Res DOI: 10.1055/a-1157-0511Primary aldosteronism (PA) was reported to frequently harbor not only cardiovascular diseases but also some metabolic disorders including secondary calcium metabolic diseases. Recently, the potential association between aldosterone producing cells and systemic calcium metabolism has been proposed. For instance, PA is frequently associated with hypercalciuria or hypocalcemia, which subsequently stimulates parathyroid hormone (PTH) secretion. This altered calcium metabolism in PA patients could frequently result in secondary osteoporosis and fra...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Gao, Xin Yamazaki, Yuto Tezuka, Yuta Omata, Kei Ono, Yoshikiyo Morimoto, Ryo Nakamura, Yasuhiro Satoh, Fumitoshi Sasano, Hironobu Tags: Review Source Type: research

The Impact of Glucocorticoid Co-Secretion in Primary Aldosteronism on Thyroid Autoantibody Titers During the Course of Disease
Horm Metab Res DOI: 10.1055/a-1164-1944Excess aldosterone is associated with the increased risk of cardio-/cerebrovascular events as well as metabolic comorbidities not only due to its hypertensive effect but also due to its proinflammatory action. Autonomous cortisol secretion (ACS) in the setting of primary aldosteronism (PA) is known to worsen cardiovascular outcome and potentially exhibit immunosuppressive effects. The aim of this study was to determine the impact of ACS status in patients with PA on kinetics of thyroid autoantibodies (anti-TPO, anti-TG) pre and post therapy in...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Handgriff, Laura Adolf, Christian Heinrich, Daniel A. Braun, Leah Nirschl, Nina Sturm, Lisa Ladurner, Roland Ricke, Jens Seidensticker, Max Bidlingmaier, Martin Reincke, Martin Tags: Endocrine Research Source Type: research

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity
Horm Metab Res 2020; 52: 336-339 DOI: 10.1055/a-1149-9347Growth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Our observations suggest that MIA-602 protects against the H2O2-induced breakdown of the brain endothelium and enhances its integrity by inducing P53, deactiva...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Barabutis, Nektarios Akhter, Mohammad S. Uddin, Mohammad A. Kubra, Khadeja-Tul Schally, Andrew V. Tags: Endocrine Research Source Type: research

The Remission Rate of Type 2 Diabetes Outpatients with Premixed Insulin: The Result of a 5-Year Prospective Study
Horm Metab Res 2020; 52: 316-321 DOI: 10.1055/a-1128-6957The aim of the study was to evaluate the remission rate with short-term premixed insulin therapy in newly diagnosed type 2 diabetes outpatients and investigate predictors contributing to the remission rate. A 5-year prospective study was conducted with a total of 170 patients enrolled. Patients were treated with premixed insulin monotherapy or insulin in combination with one or two oral drugs. After glucose levels were well controlled, insulin and oral drugs were discontinued in a stepwise manner. The prolonged and partial re...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Liu, Fu-peng Sun, Ming-hui Zhao, Jun-yu Yang, Ming Zhou, Xiao-jun Zhang, Zhong-wen Dong, Jian-jun Liao, Lin Tags: Endocrine Care Source Type: research

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials
Horm Metab Res 2020; 52: 305-315 DOI: 10.1055/a-1153-0657It is reported that vitamin D deficiency is associated with carotid intima-media thickness (CIMT). In addition, several randomized clinical trials (RCTs) have studied the influence of vitamin D supplement on CIMT. However, results are inconclusive. This review aimed to systematically explore the potential link of the serum vitamin D level with CIMT pooling together observational studies and RCTs. PubMed and Scopus were searched for studies published until February 13, 2018. The Fisher’s z (SE) correlation coefficient, odds ratio (OR), and mean (SD) of changes i...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: S äidifard, Nasim Tangestani, Hadith Djafarian, Kurosh Shab-Bidar, Sakineh Tags: Endocrine Care Source Type: research

FGF23 Beyond the Kidney: A New Bone Mass Regulator in the General Population
Horm Metab Res 2020; 52: 298-304 DOI: 10.1055/a-1151-2342Clinical studies investigating the relationship between fibroblast growth factor 23 (FGF23) and bone mass are controversial, especially in the healthy renal population. Our study is one of the forefronts investigating the relationship between FGF23 and bone mass parameters in the general population, according to age, sex, menopausal, and nutritional status. Cross-sectional study enrolling 123 volunteers between 20–80 years of age without primary osteoporosis under treatment nor secondary osteoporosis, where bone mass (bone mineral density-BMD, bone mineral cont...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Bilha, Stefana Catalina Bilha, Andrei Ungureanu, Maria-Christina Matei, Anca Florescu, Alexandru Preda, Cristina Covic, Adrian Branisteanu, Dumitru Tags: Endocrine Care Source Type: research

Research Progress on lncRNA Functions and Mechanisms in Pituitary Adenomas
Horm Metab Res 2020; 52: 280-288 DOI: 10.1055/a-1142-8815Despite being the most common human neuroendocrine tumor, the pathogenesis of pituitary adenomas (PAs) is still unclear. Long non-coding RNA (lncRNA) is involved in a variety of physiological and pathological processes, and has been shown to play a key role in the process of tumor instigation and development by affecting the proliferation, migration, invasiveness, and metastasis of tumor cells. Therefore, lncRNAs may be used as diagnostic and prognostic markers of tumors. In this paper, the effect of lncRNA on the onset and progression of PAs is reviewed so as to pro...
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Du, Qiu Yao, De-shan Wang, You-wei Cheng, Cheng Tags: Review Source Type: research

Association of VEGF Gene Polymorphisms with Susceptibility to Diabetic Retinopathy: A Systematic Review and Meta-Analysis
This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR, and NPDR. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 13, 2020 Category: Endocrinology Authors: Yang, Qianhui Zhang, Yan Zhang, Xiaomin Li, Xiaorong Liu, Juping Tags: Review Source Type: research

Morphological and Molecular Assessment in Thyroid Cytology Using Cell-Capturing Scaffolds
In conclusion, we suggest that CytoMatrix could be a reliable tool to overcome the current limits of traditional collection methods for the study of thyroid cytology, thereby improving their reliability for a conclusive diagnostic interpretation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 11, 2020 Category: Endocrinology Authors: Scarpino, Stefania Taccogna, Silvia Pepe, Giuseppina Papini, Enrico D ’Angelo, Martina Cascone, Federica Nicoletti, Daniele Guglielmi, Rinaldo Palermo, Andrea Trombetta, Marcella Rainer, Alberto Taffon, Chiara Crescenzi, Anna Tags: Endocrine Care Source Type: research

Liraglutide Ameliorates Lipotoxicity-Induced Oxidative Stress by Activating the NRF2 Pathway in HepG2 Cells
Horm Metab Res DOI: 10.1055/a-1157-0166Although glucagon-like peptide-1 (GLP-1) analogue has been reported to suppress oxidative stress in non-alcoholic fatty liver disease (NAFLD), an effective therapeutic agent for NAFLD is currently unavailable. Therefore, in this study, we aimed to investigate the protective effects of the GLP-1 analogue liraglutide against lipotoxicity-induced oxidative stress in HepG2 cells and to elucidate the underlying mechanisms. HepG2 cells were cultured for 48 hours and treated with a free fatty acid (FFA) mixture: FFA mixture and liraglutide or FFA mixture, l...
Source: Hormone and Metabolic Research - May 6, 2020 Category: Endocrinology Authors: Zhu, Chong-gui Luo, Ying Wang, Hao Li, Jun-Yi Yang, Jie Liu, Ya-xin Qu, Hui-qi Wang, Bao-li Zhu, Mei Tags: Endocrine Research Source Type: research

Effects of TNF- α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1161-0088Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the major factors of morbidity and mortality in the patients with diabetes mellitus (DM). Growing studies have investigated the relationship between the TNF-α-308G/A polymorphism and the susceptibility to DN and DR, without achieving consensus. Thus, we conducted this meta-analysis to reach more comprehensive conclusions for these issues. Eligible studies were retrieved through electronic databases such as PubMed, Embase, Web of Science and China National Knowledge Infrastructure. Summ...
Source: Hormone and Metabolic Research - May 5, 2020 Category: Endocrinology Authors: Liu, Mengwei Shang, Mengke Wang, Yue Li, Qian Liu, Xiuping Yang, Luping Zhang, Qian Zhang, Kaili Liu, Shan Nie, Fangfang Zeng, Fanxin Wen, Youhan Liu, Wanyang Tags: Endocrine Care Source Type: research

Primary Aldosteronism: Where Are We Now? Where to from Here?
Horm Metab Res DOI: 10.1055/a-1120-8623The past nine years have seen major advances in establishing the etiology of unilateral primary aldosteronism, and very possibly that of bilateral hyperaldosteronism, in response to somatic mutations in aldosterone synthase expressing cells. Though there have been important advances in the management of primary aldosteronism, in small but convincing studies, they represent minor changes to current guidelines. What has been totally absent is consideration of the public health issue that primary aldosterone represents, and the public policy issues that...
Source: Hormone and Metabolic Research - May 4, 2020 Category: Endocrinology Authors: Funder, John Watson Tags: Review Source Type: research

Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study
We describe three cases who were diagnosed with recurrent subacute thyroiditis after a reduction in prednisolone (PSL) dose, either immediately upon the cessation of PSL or shortly thereafter. Their symptoms, including the adverse effects of PSL, severely impacted their quality of life. After a complete assessment, we administered colchicine at 1 mg per day for 1–2 months to control the recurrence of SAT and monitored their routine blood parameters every two weeks. All 3 patients were successfully tapered off of PSL treatment and were free of frequently recurrent SAT. Colchicin...
Source: Hormone and Metabolic Research - May 4, 2020 Category: Endocrinology Authors: Tian, Zhenhua Su, Yu Zhang, Meijie Zhang, Xiujuan Guan, Qingbo Tags: Endocrine Care Source Type: research

Primary Aldosteronism: Where Are We Now? Where to from Here?
Horm Metab Res DOI: 10.1055/a-1120-8623The past nine years have seen major advances in establishing the etiology of unilateral primary aldosteronism, and very possibly that of bilateral hyperaldosteronism, in response to somatic mutations in aldosterone synthase expressing cells. Though there have been important advances in the management of primary aldosteronism, in small but convincing studies, they represent minor changes to current guidelines. What has been totally absent is consideration of the public health issue that primary aldosterone represents, and the public policy issues that would be involved in addressing th...
Source: Hormone and Metabolic Research - May 4, 2020 Category: Endocrinology Authors: Funder, John Watson Tags: Review Source Type: research

Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study
We describe three cases who were diagnosed with recurrent subacute thyroiditis after a reduction in prednisolone (PSL) dose, either immediately upon the cessation of PSL or shortly thereafter. Their symptoms, including the adverse effects of PSL, severely impacted their quality of life. After a complete assessment, we administered colchicine at 1 mg per day for 1–2 months to control the recurrence of SAT and monitored their routine blood parameters every two weeks. All 3 patients were successfully tapered off of PSL treatment and were free of frequently recurrent SAT. Colchicine may be therapeutic in patients with pr...
Source: Hormone and Metabolic Research - May 4, 2020 Category: Endocrinology Authors: Tian, Zhenhua Su, Yu Zhang, Meijie Zhang, Xiujuan Quan, Qingbo Tags: Endocrine Care Source Type: research

Effects of Short Term Metformin Treatment on Brown Adipose Tissue Activity and Plasma Irisin Levels in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
Horm Metab Res DOI: 10.1055/a-1157-0615Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic disorders that can be ameliorated by treatment with metformin. Brown adipose tissue (BAT) has been recently identified in adult humans, and irisin is a myokine that induces BAT formation. The aim of this randomized controlled trial was to evaluate whether a short term treatment with metformin alters BAT activity and plasma irisin levels in women with PCOS. The participants were randomly assigned to receive metformin (1500 mg/day, n=21) or placebo (n=24) during 60 days. BAT activity was asse...
Source: Hormone and Metabolic Research - May 4, 2020 Category: Endocrinology Authors: Oliveira, Fl ávia R. Mamede, Marcelo Bizzi, Mariana F. Rocha, Ana Luiza L. Ferreira, Cl áudia N. Gomes, Karina B. C ândido, Ana L. Reis, Fernando M. Tags: Endocrine Care Source Type: research

In situ Metabolite Mass Spectrometry Imaging: New Insights into the Adrenal Gland
Horm Metab Res DOI: 10.1055/a-1129-6947The adrenal gland integrates catecholamine-producing neuroendocrine cells and steroid-producing cells with mesenchymal origin in a structured manner under one capsule and is a key regulator for vital bioactivity. In addition to adrenal-specific disease, dysregulation of adrenal hormones is associated with systemic effects, leading to undesirable metabolic and cardiovascular consequences. Mass spectrometry imaging (MSI) technique can simultaneously measure a broad range of biomolecules, including metabolites and hormones, which has enabled the study o...
Source: Hormone and Metabolic Research - April 29, 2020 Category: Endocrinology Authors: Li, Fengxia Feuchtinger, Annette Walch, Axel Sun, Na Tags: Review Source Type: research

In situ Metabolite Mass Spectrometry Imaging: New Insights into the Adrenal Gland
Horm Metab Res DOI: 10.1055/a-1129-6947The adrenal gland integrates catecholamine-producing neuroendocrine cells and steroid-producing cells with mesenchymal origin in a structured manner under one capsule and is a key regulator for vital bioactivity. In addition to adrenal-specific disease, dysregulation of adrenal hormones is associated with systemic effects, leading to undesirable metabolic and cardiovascular consequences. Mass spectrometry imaging (MSI) technique can simultaneously measure a broad range of biomolecules, including metabolites and hormones, which has enabled the study of tissue metabolic and hormone alte...
Source: Hormone and Metabolic Research - April 29, 2020 Category: Endocrinology Authors: Li, Fengxia Feuchtinger, Annette Walch, Axel Sun, Na Tags: Review Source Type: research

The ACE-2 in COVID-19: Foe or Friend?
Horm Metab Res DOI: 10.1055/a-1155-0501COVID-19 is a rapidly spreading outbreak globally. Emerging evidence demonstrates that older individuals and people with underlying metabolic conditions of diabetes mellitus, hypertension, and hyperlipidemia are at higher risk of morbidity and mortality. The SARS-CoV-2 infects humans through the angiotensin converting enzyme (ACE-2) receptor. The ACE-2 receptor is a part of the dual system renin-angiotensin-system (RAS) consisting of ACE-Ang-II-AT1R axis and ACE-2-Ang-(1–7)-Mas axis. In metabolic disorders and with increased age, it is known th...
Source: Hormone and Metabolic Research - April 27, 2020 Category: Endocrinology Authors: Dalan, Rinkoo Bornstein, Stefan R. El-Armouche, Ali Rodionov, Roman N Markov, Alexander Wielockx, Ben Beuschlein, Felix Boehm, Bernhard O. Tags: Immediate Interest Source Type: research

Developments in Primary Aldosteronism Subtyping Using Steroid Profiling
Horm Metab Res DOI: 10.1055/a-1141-3526Adrenal venous sampling is the standard of care for identifying patients with unilateral primary aldosteronism, which is often caused by an aldosterone producing adenoma and can be cured with surgery. The numerous limitations of adrenal venous sampling, including its high cost, scarce availability, technical challenges, and lack of standardized protocols, have driven efforts to develop alternative, non-invasive tools for the diagnosis of aldosterone producing adenomas. Seminal discoveries regarding the pathogenesis of aldosterone producing adenomas m...
Source: Hormone and Metabolic Research - April 24, 2020 Category: Endocrinology Authors: Wannachalee, Taweesak Turcu, Adina F. Tags: Review Source Type: research

Moderators of the Association Between Serum Parathyroid Hormone and Metabolic Syndrome in Participants with Elevated Parathyroid Hormone: NHANES 2003 –2006
In conclusion, increased serum PTH concentration is associated with higher MetS severity scores in participants with elevated serum PTH at baseline. The association between PTH concentration and MetS severity is moderated by participants’ physical activity levels, status of serum vitamin D, vitamin D supplementation, and daily protein intake. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 23, 2020 Category: Endocrinology Authors: Chen, Liang Pei, Jian-Hao Kuang, Jian Tags: Endocrine Care Source Type: research

Clinical and Molecular Update on Genetic Causes of Pituitary Adenomas
Horm Metab Res DOI: 10.1055/a-1143-5930Pituitary adenomas are benign tumors with variable functional characteristics that can have a significant impact on patients. The majority arise sporadically, but an inherited genetic susceptibility is increasingly being recognized. Recent advances in genetics have widened the scope of our understanding of pituitary tumorigenesis. The clinical and genetic characteristics of pituitary adenomas that develop in the setting of germline-mosaic and somatic GNAS mutations (McCune–Albright syndrome and sporadic acromegaly), germline MEN1 mutations (multiple endocrine neoplasia type 1), ...
Source: Hormone and Metabolic Research - April 16, 2020 Category: Endocrinology Authors: Vasilev, Vladimir Daly, Adrian F. Zacharieva, Sabina Beckers, Albert Tags: Review Source Type: research

Update on the Treatment of Medullary Thyroid Carcinoma in Patients with Multiple Endocrine Neoplasia Type 2
This article discusses hereditary MTC in the setting of MEN2 and the treatment options available for it. The first line treatment for this disease is typically a total thyroidectomy and tyrosine kinase inhibitors. Two tyrosine kinase inhibitors, vandetanib and cabozantinib, have been approved for treatment of advanced MTC, but options beyond those are limited. However, several promising treatments are being studied, which are discussed in this review. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract&n...
Source: Hormone and Metabolic Research - April 16, 2020 Category: Endocrinology Authors: Ilanchezhian, Maran Khan, Sophia Okafor, Christian Glod, John Del Rivero, Jaydira Tags: Review Source Type: research

Identification of Novel Variants in MEN1: A Study Conducted with Four Multiple Endocrine Neoplasia Type 1 Patients
Horm Metab Res DOI: 10.1055/a-1147-1375Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited endocrine tumor syndrome caused by inactivating variants of the MEN1 gene. The aim of this study is to explore the clinical and genetic characteristics of four MEN1 patients. We isolated genomic deoxyribonucleic acid from lymphocytes, parathyroid, and thymic tumoral tissue specimens from the MEN1 patients. All exons of the MEN1 and CDNK1B genes and adjacent exon-intron sequences were amplified by polymerase chain reaction and subsequently sequenced. Further, the splice alte...
Source: Hormone and Metabolic Research - April 16, 2020 Category: Endocrinology Authors: Hu, Wen-mu Zhang, Qin Huang, Li-hua Mo, Zhao-hui Long, Xiao-dan Yang, You-bo Yang, Wen-jun Liu, Jun Jin, Ping Tags: Endocrine Care Source Type: research

Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1139-2079The CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone. CYP11B2 expression is normally stimulated by angiotensin II, but becomes autonomous in primary hyperaldosteronism, in most cases driven by recently discovered somatic mutations of ion channels or pumps. Cells expressing CYP11B2 in young normal humans form a continuous band beneath the adrenal capsule; in older individuals they form discrete clusters, aldosteron...
Source: Hormone and Metabolic Research - April 14, 2020 Category: Endocrinology Authors: Gomez-Sanchez, Celso E. Gomez-Sanchez, Elise P. Nishimoto, Koshiro Tags: Review Source Type: research

Atrial Fibrillation in Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1141-5989Primary aldosteronism (PA) is the most common cause of secondary hypertension. Increasing evidence has demonstrated an increased cardiovascular risk in patients with PA compared to those with essential hypertension (EH), including atrial fibrillation (AF), the most prevalent arrhythmia among adults that is associated with an elevated risk of subsequent cerebro-cardiovascular adverse events. The mechanisms of increased prevalence of AF in PA patients are complex. Excessive aldosterone production is regarded to be a key component in the pathogenesis of AF, in addition to arterial hypert...
Source: Hormone and Metabolic Research - April 14, 2020 Category: Endocrinology Authors: Pan, Chien-Ting Tsai, Cheng-Hsuan Chen, Zheng-Wei Chang, Yi-Yao Wu, Vin-Cent Hung, Chi-Sheng Lin, Yen-Hung Tags: Review Source Type: research

Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1139-2079The CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone. CYP11B2 expression is normally stimulated by angiotensin II, but becomes autonomous in primary hyperaldosteronism, in most cases driven by recently discovered somatic mutations of ion channels or pumps. Cells expressing CYP11B2 in young normal humans form a continuous band beneath the adrenal capsule; in older individuals they form discrete clusters, aldosterone-producing cell clusters (APCC), s...
Source: Hormone and Metabolic Research - April 14, 2020 Category: Endocrinology Authors: Gomez-Sanchez, Celso E. Gomez-Sanchez, Elise P. Nishimoto, Koshiro Tags: Review Source Type: research

Response to Letter to the Editor Entitled: Concerning the Article by Arezoo Maleki-Hajiagha et al. Entitled Serum Prostate-Specific Antigen Level in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Horm Metab Res 2020; 52: 252-252 DOI: 10.1055/a-1089-7970Dear Editor,We thank Kunicki et al. 1 for their interest in our paper 2 and for taking the time to give relevant and important comments regarding the inclusion of hirsutism or hyperandrogenism cases in our study. We agree with Kunicki et al. that the title is not appropriate, and it was better if the title of the article was: Serum Prostate-Specific Antigen Level in Women with Polycystic Ovary Syndrome and Hyperandrogenism: A Systematic Review and Meta-Analysis. Also, we should make some minor editing in the manuscript text. [...] &...
Source: Hormone and Metabolic Research - April 8, 2020 Category: Endocrinology Authors: Maleki-Hajiagha, Arezoo Razavi, Maryam Rezaeinejad, Mahroo Sepidarkish, Mahdi Mehri, Ahmad Vesali, Samira Allameh, Zahra Tags: Letter to the Editor Source Type: research

Concerning the Article by Arezoo Maleki-Hajiagha et al. entitled: Serum Prostate-Specific Antigen Level in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis
Horm Metab Res 2020; 52: 251-251 DOI: 10.1055/a-1089-7739Dear Editor,We carefully read with a great interest the study of Arezoo Maleki-Hajiagha et al. entitled: Serum Prostate-Specific Antigen Level in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis 1. We thank the authors for their hard work and also citing our latest work in this field-covering the largest study population ( Rudnicka et al. 2016) 2. However, we think that the title of that meta-analysis is not appropriate and the conclusions are not adequate. [...] © Georg Thieme Verlag KG Stuttgart · New ...
Source: Hormone and Metabolic Research - April 8, 2020 Category: Endocrinology Authors: Kunicki, Micha ł Rudnicka, Ewa Smolarczyk, Roman Tags: Letter to the Editor Source Type: research

Immunomodulating Effects Depend on Prolactin Levels in Patients with Hyperprolactinemia
The objective of this work was to assess if hyperprolactinemia not related to pregnancy is associated with changes in circulating levels of chemokines and other immunological markers. In this cross sectional study, 35 patients with hyperprolactinemia (5 men), and 102 healthy blood donors (19 men) were included. Serum levels of Th1- Th2- and Th17-associated chemokines, C-reactive protein, immunoglobulins, and the B cell attracting chemokine CXCL13 were assessed. The hyperprolactinemic group had significantly higher levels of Th2 associated CCL22 (p=0.022), Th17 associated CXCL1 (p=0.001), ...
Source: Hormone and Metabolic Research - April 8, 2020 Category: Endocrinology Authors: Ewerman, Lea Landberg, Eva Hellberg, Sandra Hovland, Mina Sundin, Anna Jenmalm, Maria C. Ekman, Bertil Ernerudh, Jan Wahlberg, Jeanette Tags: Endocrine Care Source Type: research

Clinical Characteristics, Management, and Treatment Outcomes of Primary Hypophysitis: A Monocentric Cohort
Horm Metab Res 2020; 52: 220-227 DOI: 10.1055/a-1113-7777Primary hypophysitis (PH) is a rare autoimmune inflammatory disease of the pituitary gland. The aim of the study was to evaluate clinical characteristics, disease management, and outcomes of cases with PH. Medical records of PH patients admitted to Hacettepe University Hospital between 1999 and 2017 were analyzed retrospectively. Paraffin-embedded pathology blocks were obtained for both re-examination and IgG4 immunostaining. Twenty PH patients (15 females, 5 males) were evaluated. Mean age at diagnosis was 41.5±13.4 y...
Source: Hormone and Metabolic Research - April 8, 2020 Category: Endocrinology Authors: Oguz, Seda Hanife Soylemezoglu, Figen Sendur, Suleyman Nahit Mut, Melike Oguz, Kader Karli Dagdelen, Selcuk Erbas, Tomris Tags: Endocrine Care Source Type: research

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis
Horm Metab Res 2020; 52: 207-215 DOI: 10.1055/a-1129-6785Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model ...
Source: Hormone and Metabolic Research - April 8, 2020 Category: Endocrinology Authors: Askarpour, Moein Alizadeh, Shahab Hadi, Amir Symonds, Michael E. Miraghajani, Maryam Sheikhi, Ali Ghaedi, Ehsan Tags: Review Source Type: research

Hypokalemia and the Prevalence of Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1134-4980Hypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of comorbidities. Specifically, a growing body of evidence demonstrates that hypokalemia in PA patients is associated with a more severe disease course regarding cardiovascular and metabolic morbidity and mortality. It is also well appreciated that low potassium levels per se can promote or exacerbat...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Gruber, Sven Beuschlein, Felix Tags: Review Source Type: research

Age, Gender, and Body Mass Index as Determinants of Surgical Outcome in Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1139-1783Although unilateral primary aldosteronism (PA) should be curable by adrenalectomy (ADX), postsurgical outcome is affected by several clinical factors. Herein we reviewe the importance of age, gender, and BMI as determinants of surgical success based on the recent findings including a nation-wide, multicenter study in Japan (JPAS/JRAS). It is important to determine whether ADX for elderly patients with unilateral PA is as beneficial as younger patients. JPAS/JRAS showed that ADX could benefit elderly patients (>65 years) with definitive unilateral ...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Naruse, Mitsuhide Yamamoto, Koichi Katabami, Takuyuki Nakamaru, Ryo Sone, Masakatsu Kobayashi, Hiroki Tanabe, Akiyo Tags: Review Source Type: research

Hypokalemia and the Prevalence of Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1134-4980Hypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of comorbidities. Specifically, a growing body of evidence demonstrates that hypokalemia in PA patients is associated with a more severe disease course regarding cardiovascular and metabolic morbidity and mortality. It is also well appreciated that low potassium levels per se can promote or exacerbate hypertension. The spectrum of hypokalemi...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Gruber, Sven Beuschlein, Felix Tags: Review Source Type: research

Salt Appetite and its Effects on Cardiovascular Risk in Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-1116-2407First described in 1955 by Jerome W. Conn, primary aldosteronism (PA) today is well established as a relevant cause of secondary hypertension and accounts for about 5–10 % of hypertensives. The importance of considering PA is based on its deleterious target organ damage far beyond the effect of elevated blood pressure and on PA being a potentially curable form of hypertension. Aside the established contributory role of high dietary salt intake to arterial hypertension and cardiovascular disease, high salt intake is mandatory for aldosterone-med...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Adolf, Christian Schneider, Holger Heinrich, Daniel A. Handgriff, Laura Reincke, Martin Tags: Review Source Type: research

Effects of Metformin and Sitagliptin Monotherapy on Expression of Intestinal and Renal Sweet Taste Receptors and Glucose Transporters in a Rat Model of Type 2 Diabetes
Horm Metab Res DOI: 10.1055/a-1135-9031Disordered intestinal sweet taste receptors (STRs) are implicated in glucose homeostasis by involving in incretin secretion and glucose absorption. However, the effects of antidiabetic medications on STRs, downstream molecules, and glucose transporters expression are unknown. In our study, ZDF rats (n=24) were randomly treated by metformin (MET, 215.15 mg/kg), sitagliptin (SIT, 10.76 mg/kg), or saline for 4 weeks. Fasting blood glucose and insulin levels were measured, and HOMA-IR and QUICKI index were calculated. One week later, we det...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Zhang, Minchun Feng, Rilu Yue, Jiang Qian, Cheng Yang, Mei Liu, Wei Rayner, Christopher K. Ma, Jing Tags: Endocrine Research Source Type: research

COMP-Ang-1 Improves Glucose Uptake in db/db Mice with Type 2 Diabetes
Horm Metab Res DOI: 10.1055/a-1126-4402Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in ob/ob mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic db/db mouse model. COMP-Ang-1 (0.5 ng/g body weight) or aqueous N...
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Baum, Petra Paeschke, Sabine Kl öting, Nora Bl üher, Matthias Kern, Matthias Serke, Heike Nowicki, Marcin Kosacka, Joanna Tags: Endocrine Research Source Type: research

Serum Visfatin does not seem to be a Useful Marker to Guide Glucocorticoid Substitution in Adrenal Insufficiency
This study was aimed to investigate whether serum visfatin could guide the glucocorticoid substitution in AD. Biochemical analyses were performed in 96 patients with AD (mean age 43.3±14.9 years) and 91 controls (43.5±12.5 years). Visfatin level was significantly elevated in patients with AD compared to controls (p
Source: Hormone and Metabolic Research - April 6, 2020 Category: Endocrinology Authors: Fichna, Marta Czarnywojtek, Agata Sowi ńska, Anna Gryczy ńska, Maria Gut, Pawe ł Rucha ła, Marek Tags: Endocrine Care Source Type: research

The Potential Role of Aldosterone-Producing Cell Clusters in Adrenal Disease
Horm Metab Res DOI: 10.1055/a-1128-0421Primary aldosteronism (PA) is the most common cause of secondary hypertension. The hallmark of PA is adrenal production of aldosterone under suppressed renin conditions. PA subtypes include adrenal unilateral and bilateral hyperaldosteronism. Considerable progress has been made in defining the role for somatic gene mutations in aldosterone-producing adenomas (APA) as the primary cause of unilateral PA. This includes the use of next-generation sequencing (NGS) to define recurrent somatic mutations in APA that disrupt calcium signaling, increase aldost...
Source: Hormone and Metabolic Research - March 30, 2020 Category: Endocrinology Authors: Lim, Jung Soo Rainey, William E. Tags: Review Source Type: research

Clinical and Molecular Genetics of Primary Hyperparathyroidism
Horm Metab Res DOI: 10.1055/a-1132-6223Calcium homeostasis is maintained by the actions of the parathyroid glands, which release parathyroid hormone into the systemic circulation as necessary to maintain the serum calcium concentration within a tight physiologic range. Excessive secretion of parathyroid hormone from one or more neoplastic parathyroid glands, however, causes the metabolic disease primary hyperparathyroidism (HPT) typically associated with hypercalcemia. Although the majority of cases of HPT are sporadic, it can present in the context of a familial syndrome. Mutations in the tumor suppressor genes discovered...
Source: Hormone and Metabolic Research - March 30, 2020 Category: Endocrinology Authors: Simonds, William F. Tags: Review Source Type: research

The Potential Role of Aldosterone-Producing Cell Clusters in Adrenal Disease
Horm Metab Res DOI: 10.1055/a-1128-0421Primary aldosteronism (PA) is the most common cause of secondary hypertension. The hallmark of PA is adrenal production of aldosterone under suppressed renin conditions. PA subtypes include adrenal unilateral and bilateral hyperaldosteronism. Considerable progress has been made in defining the role for somatic gene mutations in aldosterone-producing adenomas (APA) as the primary cause of unilateral PA. This includes the use of next-generation sequencing (NGS) to define recurrent somatic mutations in APA that disrupt calcium signaling, increase aldosterone synthase (CYP11B2) expression...
Source: Hormone and Metabolic Research - March 30, 2020 Category: Endocrinology Authors: Lim, Jung Soo Rainey, William E. Tags: Review Source Type: research

Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?
Horm Metab Res DOI: 10.1055/a-1133-7255The coexistence of aldosterone oversecretion and obstructive sleep apnea is frequently observed, especially in patients with resistant hypertension, obesity, and metabolic syndrome. Since aldosterone excess and sleep apnea are both independently associated with an increased risk of cardiovascular disease, to investigate whether their coexistence might be attributed to common predisposing conditions, such as metabolic disorders, or to an actual pathophysiological interconnection appears of great importance. Fluid overload and metabolic abnormalities r...
Source: Hormone and Metabolic Research - March 27, 2020 Category: Endocrinology Authors: Pecori, Alessio Buffolo, Fabrizio Pieroni, Jacopo Forestiero, Vittorio Sconfienza, Elisa Veglio, Franco Mulatero, Paolo Monticone, Silvia Tags: Review Source Type: research

Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?
Horm Metab Res DOI: 10.1055/a-1133-7255The coexistence of aldosterone oversecretion and obstructive sleep apnea is frequently observed, especially in patients with resistant hypertension, obesity, and metabolic syndrome. Since aldosterone excess and sleep apnea are both independently associated with an increased risk of cardiovascular disease, to investigate whether their coexistence might be attributed to common predisposing conditions, such as metabolic disorders, or to an actual pathophysiological interconnection appears of great importance. Fluid overload and metabolic abnormalities relating to aldosterone oversecretio...
Source: Hormone and Metabolic Research - March 27, 2020 Category: Endocrinology Authors: Pecori, Alessio Buffolo, Fabrizio Pieroni, Jacopo Forestiero, Vittorio Sconfienza, Elisa Veglio, Franco Mulatero, Paolo Monticone, Silvia Tags: Review Source Type: research

Effects of ACE Inhibitors and Angiotensin Receptor Blockers in Normotensive Patients with Diabetic Kidney Disease
Horm Metab Res DOI: 10.1055/a-1138-0959The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in reducing the progression of albuminuria and risk of cardiovascular events in hypertensive patients with diabetic kidney disease (DKD) is well-documented. However, the efficacy and safety of these agents in normotensive patients with DKD are still controversial. MEDLINE, Embase, and Cochrane Library were searched for relevant random controlled trials. The odd risk (OR) reductions were calculated with a random-effects model. Decrease in albuminuria,...
Source: Hormone and Metabolic Research - March 27, 2020 Category: Endocrinology Authors: He, Dandan Zhang, Yaru Zhang, Wei Xing, Yue Guo, Yipeng Wang, Fuzhen Jia, Junya Yan, Tiekun Liu, Youxia Lin, Shan Tags: Endocrine Care Source Type: research

Role of Mast Cells in the Control of Aldosterone Secretion
Horm Metab Res DOI: 10.1055/a-1119-1063Mast cells are immune cells present in adrenals from various species. Proliferation and activation of adrenal mast cells seem to be influenced by environment, since they increase during summer and in response to sodium restriction in frogs and mouse, respectively. Although the physiological factors regulating adrenal mast cell activity have not been identified, they might involve neurotransmitters and the renin-angiotensin system. Some data indicate that adrenal mast cells stimulate proliferation of steroidogenic cells in the zona glomerulosa and act...
Source: Hormone and Metabolic Research - March 25, 2020 Category: Endocrinology Authors: Lopez, Antoine-Guy Duparc, C éline Naccache, Alexandre Castanet, Mireille Lefebvre, Herv é Louiset, Estelle Tags: Review Source Type: research

Role of Mast Cells in the Control of Aldosterone Secretion
Horm Metab Res DOI: 10.1055/a-1119-1063Mast cells are immune cells present in adrenals from various species. Proliferation and activation of adrenal mast cells seem to be influenced by environment, since they increase during summer and in response to sodium restriction in frogs and mouse, respectively. Although the physiological factors regulating adrenal mast cell activity have not been identified, they might involve neurotransmitters and the renin-angiotensin system. Some data indicate that adrenal mast cells stimulate proliferation of steroidogenic cells in the zona glomerulosa and activate the mineralocorticoid product...
Source: Hormone and Metabolic Research - March 25, 2020 Category: Endocrinology Authors: Lopez, Antoine-Guy Duparc, C éline Naccache, Alexandre Castanet, Mireille Lefebvre, Herv é Louiset, Estelle Tags: Review Source Type: research