Salivary Cortisol Measurement Contamination After Oral
Hydrocortisone: A Randomized Crossover Trial
Horm Metab Res DOI: 10.1055/a-2271-0700The study aimed to evaluate salivary cortisol (SC) contamination and determine
the associated factors in secondary adrenal insufficiency (SAI) patients treated
with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC
was measured before the morning Hc dose, then at one, two, and four hours after.
The procedure was performed twice on two days of a week: one day while taking Hc
in tablet form (tablet set) and one day while taking Hc in capsule form (capsule
set). Area under the curve (AUC) of SC levels o...
Source: Hormone and Metabolic Research - March 6, 2024 Category: Endocrinology Authors: Chihaoui, Melika Mouelhi, Yasmine Hammami, Bessem Oueslati, Ibtissem Khessairi, Nadia Chaker, Fatma Yazidi, Meriem Feki, Moncef Tags: Original Article: Endocrine Care Source Type: research
Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis,
and Treatment
Horm Metab Res DOI: 10.1055/a-2246-2900Glucocorticoid-induced myopathy is a non-inflammatory toxic myopathy typified by
proximal muscle weakness, muscle atrophy, fatigue, and easy fatigability. These
vague symptoms coupled with underlying disorders may mask the signs of
glucocorticoid-induced myopathy, leading to an underestimation of the disease’s
impact. This review briefly summarizes the classification, pathogenesis, and
treatment options for glucocorticoid-induced muscle wasting. Additionally, we
discuss current diagnostic measures in clinical research and r...
Source: Hormone and Metabolic Research - March 4, 2024 Category: Endocrinology Authors: Wu, Mengmeng Liu, Caixia Sun, Dong Tags: Review Source Type: research
Preservation of β-Cells as a Therapeutic Strategy for
Diabetes
In conclusion, preserving
β-cells offers a promising approach to managing both types of diabetes. By
combining lifestyle modifications, targeted pharmacological interventions, and
advanced therapies like stem cell transplantation and bariatric surgery, we have
a significant chance to preserve β-cell function and enhance glucose regulation
in diabetic patients. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - February 22, 2024 Category: Endocrinology Authors: Taneera, Jalal Saber-Ayad, Maha M. Tags: Review Source Type: research
Revealing Melatonin ’s Mysteries: Receptors, Signaling
Pathways, and Therapeutics Applications
Horm Metab Res DOI: 10.1055/a-2226-3971Melatonin (5-methoxy-acetyl tryptamine) is a sleep-inducing hormone, and the
pineal gland produces it in response to the circadian clock of darkness. In the
body, MT1 and MT2 receptors are mostly found, having an orthosteric pocket and
ligand binding determinants. Melatonin acts by binding on melatonin receptors,
intracellular proteins, and orphan nuclear receptors. It inhibits adenyl cyclase
and activates phospholipase C, resulting in gene expression and an intracellular
alteration environment. Melatonin signaling pathways a...
Source: Hormone and Metabolic Research - February 19, 2024 Category: Endocrinology Authors: Kulsoom, Kulsoom Ali, Wajahat Saba, Zainab Hussain, Shabab Zahra, Samra Irshad, Maria Ramzan, Muhammad Saeed Tags: Review Source Type: research
Energy Metabolism in Residents in the Low- and Moderate Altitude
Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus
Horm Metab Res DOI: 10.1055/a-2256-6358The knowledge about the features of energy metabolism in MAFLD in the population
living at different climatic and geographic heights is lacking. The goal of this
study is to explore the biochemical parameters of blood and erythrocyte energy
consumption in patients with MAFLD with and without DM2 living in the low- and
moderate-altitude regions of Central Asia. Our study was carried out on patients
living in low-altitude mountains: Bishkek, altitude=750–800 m; n=67 (MAFLD with
DM 2: n=24; MAFLD without DM2: n=25; control: ...
Source: Hormone and Metabolic Research - February 19, 2024 Category: Endocrinology Authors: Toktogulova, Nurgul Breidert, Matthias Eschbach, Judith Kudaibergenova, Indira Omurzakova, Uulkan Uvaidillaeva, Feruzakhan Tagaeva, Bermet Sultanalieva, Roza Eftekhari, Pierre Tags: Original Article: Endocrine Care Source Type: research
Utility of Simple and Non-Invasive Strategies Alternative to Inferior
Petrosal Sinus Sampling and Peripheral CRH Stimulation in Differential Diagnosis
of ACTH-Dependent Cushing Syndrome
Horm Metab Res DOI: 10.1055/a-2236-0864We aimed to evaluate the utility of simple, cost-effective, and non-invasive
strategies alternative to BIPSS and peripheral CRH stimulation in differential
diagnosis of ACTH-dependent CS. First, we performed ROC analysis to evaluate the
performance of various tests for differential diagnosis of ACTH-dependent CS in
our cohort (CD, n=76 and EAS, n=23) and derived their optimal
cut-offs. Subsequently, combining various demographic (gender), clinical
(hypokalemia), biochemical (plasma ACTH, HDDST, peripheral CRH stimulation) and...
Source: Hormone and Metabolic Research - February 16, 2024 Category: Endocrinology Authors: Attri, Bhawna Goyal, Alpesh Kalaivani, Mani Kandasamy, Devasenathipathy Gupta, Yashdeep Agarwal, Shipra Shamim, Shamim A. Damle, Nishikant Sharma, Mehar Chand Jyotsna, Viveka P. Suri, Ashish Tandon, Nikhil Tags: Original Article: Endocrine Care Source Type: research
Elevated Levels of Interleukin-18 are Associated with Lymph Node
Metastasis in Papillary Thyroid Carcinoma
In this study, we found that the expression of IL-18 was
significantly increased in PTC compared to normal thyroid tissue. Elevated IL-18
expression was closely associated with lymphovascular invasion and lymph node
metastases. Furthermore, compared to PTC patients with no nodal metastasis,
serum IL-18 levels were slightly increased in patients with 1–4 nodal
metastases and significantly elevated in patients with 5 or more nodal
metastases. The pro-metastatic effect of IL-18 may be attributed to the
simultaneous increase in the expression of S100A10, a...
Source: Hormone and Metabolic Research - February 14, 2024 Category: Endocrinology Authors: Chun, Wang Lu, Meiyin Chen, Jiakang Li, Jian Tags: Original Article: Endocrine Care Source Type: research
Targeting Abnormal Tau Phosphorylation for Alzheimer ’s
Therapeutics
Horm Metab Res DOI: 10.1055/a-2238-1384Alzheimer’s disease (AD) is a widespread neurodegenerative disorder
characterized by progressive memory and cognitive decline, posing a formidable
public health challenge. This review explores the intricate interplay between
two pivotal players in AD pathogenesis: β-amyloid (Aβ) and tau
protein. While the amyloid cascade theory has long dominated AD research, recent
developments have ignited debates about its centrality. Aβ plaques and
tau NFTs are hallmark pathologies in AD. Aducanumab and lecanemab, monoclonal
...
Source: Hormone and Metabolic Research - February 13, 2024 Category: Endocrinology Authors: Singh, Aditya Ansari, Vaseem Ahamad Mahmood, Tarique Hasan, Syed Misbahul Wasim, Rufaida Maheshwari, Shubhrat Akhtar, Juber Sheikh, Suvaiv Vishwakarma, Vishal Kumar Tags: Review Source Type: research
The Evolution of the Bone Turnover Marker in Patients Following
Recovery from Diabetic Ketoacidosis
Horm Metab Res DOI: 10.1055/a-2247-5610The aim of the study was to investigate whether the biomarkers for bone turnover
could rapidly recover during the period of diabetic ketoacidosis (DKA). Bone
turnover biomarkers, including 25-hydroxyvitamin D3, N-terminal middle molecular
fragment of osteocalcin (NMID), and β-C terminal cross-linking
telopeptide of type 1 collagen were evaluated using in-patient data
(n=627) from Shanghai Pudong Hospital from 2018–2022. The
comparison was performed between type 2 diabetes (T2D only) (n=602) and
DKA (n=25), in whi...
Source: Hormone and Metabolic Research - February 12, 2024 Category: Endocrinology Authors: Wen, Song Xu, Chenglin Yuan, Yue Li, Yanyan Xu, Dongxiang Gong, Min Zhou, Mingyue Zhou, Ligang Tags: Original Article: Endocrine Care Source Type: research
Association of Red Blood Cell and Platelet Parameters with Metabolic
Syndrome: A Systematic Review and Meta-Analysis of 170,000
Patients
Horm Metab Res DOI: 10.1055/a-2241-5361This systematic review and meta-analysis aim to establish associations between
metabolic syndrome (MetS) and erythrocyte and platelet markers, contributing to
improved diagnostic tests for identifying individuals at risk. Observational
studies and Randomized Controlled Trials (RCTs) were included. The standardized
mean difference (SMD) and 95% confidence intervals (CI) of erythrocyte
and platelet markers between individuals with and without MetS were used as
effect size (inverse variance model). Methodological quality assessm...
Source: Hormone and Metabolic Research - February 12, 2024 Category: Endocrinology Authors: Mahmood, Aysal Samad, Saba Haider, Hoorain Hassan, Wardah Mushtaq, Rabeea Perwaiz, Aimen Ali, Abraish Azharuddin, Muhammad Tags: Original Article: Endocrine Care Source Type: research
Meta-Analysis and Network Analysis Differentially Detect Various
Pro-Inflammatory Mediators and Risk Factors for Type 2 Diabetes in the
Elderly
This study aimed to investigate the association between blood
pro-inflammatory mediators and the characteristics of elderly patients with T2D
using meta and network analyses. The Web of Science, Scopus, PubMed, and
Cochrane Library databases were selected as study methodology. The Quality in
Prognosis Studies (QUIPS) tool in the meta-analysis assessed the
studies’ methodological quality. The selected studies were statistically
analyzed using the META-MAR tool based on the standardized mean difference
(SMD). The selected studies included nine examinatio...
Source: Hormone and Metabolic Research - February 12, 2024 Category: Endocrinology Authors: Gu, Linlin Du, Yue Liang, Fang Tags: Original Article: Endocrine Care Source Type: research
Potassium: A Frontier in Osteoporosis
Horm Metab Res 2024; DOI: 10.1055/a-2254-8533Osteoporosis is a significant public health concern, particularly in aging
populations, leading to fractures, decreased mobility, and reduced quality of
life. While calcium and vitamin D have long been recognized as essential for
bone health, emerging research suggests that potassium may play a crucial role
in maintaining bone density and preventing osteoporosis. This manuscript
explores the relationship between potassium and osteoporosis, delving into the
mechanisms, epidemiological evidence, and potential therapeutic ...
Source: Hormone and Metabolic Research - February 12, 2024 Category: Endocrinology Authors: Singh, Widhilika Kushwaha, Poonam Tags: HMR Women Source Type: research
ETV5 Silencing Produces Mesenchymal to Epithelial Transition in INS-1
(832/13) Cell Line
Horm Metab Res DOI: 10.1055/a-2246-4778ETV5 has been described to be involved in the epithelial to mesenchymal
transition (EMT) mainly in cancer. It is known that EMT provokes cytoskeleton
remodeling, improving cellular migratory, and invasive capabilities. Moreover,
overexpression of ETV5 has been correlated to cancer development and this
gene has been implicated in cell proliferation. However, little is known about
the downregulation of ETV5 expression in a pancreatic cell line and the
inverse mesenchymal to epithelial transition (MET). Therefore, we studied the...
Source: Hormone and Metabolic Research - February 9, 2024 Category: Endocrinology Authors: D íaz-López, Yael Efrén C ázares-Domínguez, Vicenta Arenas-Huertero, Francisco Gutierrez-Aguilar, Ruth Tags: Original Article: Endocrine Research Source Type: research
Ferroptosis: A Frontier in Osteoporosis
Horm Metab Res DOI: 10.1055/a-2230-2664Reduced bone mass and degeneration of the microarchitecture of bone tissue are
the hallmarks of osteoporosis, a bone metabolic disease that increases skeletal
fragility and fracture susceptibility. Osteoporosis is primarily caused by
unbalanced bone remodeling, in which bone synthesis is outpaced by bone
resorption caused by osteoclasts. Along with the bone-building vitamins calcium
and vitamin D, typical medications for treating osteoporosis include
bisphosphonates and calcitonin. The present therapies effectively stop
...
Source: Hormone and Metabolic Research - February 2, 2024 Category: Endocrinology Authors: Maheshwari, Shubhrat Singh, Aditya Verma, Amita Tags: Review Source Type: research
Periostin Promotes the Proliferation, Differentiation and
Mineralization of Osteoblasts from Ovariectomized Rats
Horm Metab Res DOI: 10.1055/a-2238-2553Perimenopausal period causes a significant amount of bone loss, which results in
primary osteoporosis (OP). The Periostin (Postn) may play important roles in the
pathogenesis of OP after ovariectomized (OVX) rats. To identify the roles of
Postn in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in
OVX rats, we investigated the expression of Wnt/β-catenin
signaling pathways in BMSC-OB and the effects of Postn on bone formation by
development of BMSC-OB cultures. Twenty-four female Sprague–Dawley rats
...
Source: Hormone and Metabolic Research - February 2, 2024 Category: Endocrinology Authors: Yan, Jun Wang, Zidong Xian, Li Wang, Dawei Chen, Yunzhen Bai, Jie Liu, Hai-juan Tags: Original Article: Endocrine Research Source Type: research
