Hsa_circ_0000106 Acts as a Tumor Promoter in Pancreatic Cancer by
Targeting the MiR-455 –3p/HDAC4
In conclusion, circ_0000106 promotes tumor
migration and growth in PC by targeting the miR-455–3p/HDAC4
axis. These results suggest that the
circ_0000106/miR-455–3p/HDAC4 network could be regarded
as a latent target for PC treatment. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 8, 2023 Category: Endocrinology Authors: Hao, Shunxin Yao, Zhi Liu, Yifeng Tags: Original Article: Endocrine Research Source Type: research
Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes
Mellitus by Modulating the Ferroptosis Signaling Pathway
Horm Metab Res DOI: 10.1055/a-2122-5701Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid
peroxides and lipid-reactive oxygen species. It is characterized by
iron-dependent lipid peroxide accumulation accompanied by oxidoreductase
deficiency. Pancreatic beta cell dysfunction and insulin resistance are two
major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and
metabolism may play a role in the development of T2DM. The molecular mechanism
of β cell apoptosis and iron death in T2DM were reviewed. In addition,
w...
Source: Hormone and Metabolic Research - August 1, 2023 Category: Endocrinology Authors: Zhang, Qiong-Wen Wang, Yan Tong, Zi-Ying Li, Cui-Ping He, Lian-Ping Tags: Mini-Review Source Type: research
Assessment of the Degree of Clinical Suspicion of 21-Hydroxylase
Deficiency Prior to the Newborn Screening Result
Horm Metab Res 2023; 55: 528-535 DOI: 10.1055/a-2111-6571The aim of the study was to analyze the clinical suspicion and where patients
were when they received the positive result of the neonatal screening for CAH
21OHD. The present data derived from a retrospective analysis of a relatively
large group of patients with classical CAH 21OHD patients nosed by newborn
screening in Madrid, Spain. During the period from 1990 to 2015 of this study 46
children were diagnosed with classical 21OHD [36 with the salt-wasting (SW) form
and 10 with simple virilizing (SV)]. In 38...
Source: Hormone and Metabolic Research - July 31, 2023 Category: Endocrinology Authors: Sanz Fern ández, María Mora Sitja, Marina Carrasc ón González-Pinto, Lucía L ópez Herce Arteta, Estíbaliz Rodr íguez Sánchez, Amparo Tags: Original Article: Endocrine Care Source Type: research
Pharmacological Interventions for Glucocorticoid-Induced
Osteoporosis: An Umbrella Review
Horm Metab Res 2023; 55: 511-519 DOI: 10.1055/a-2112-1596There is still a lack of high-quality evidence-based studies on the efficacy of
drug treatment for glucocorticoid-induced osteoporosis (GIOP). The purpose of
this umbrella review is to comprehensively evaluate the existing evidence to
determine the efficacy and safety of pharmacological interventions for GIOP. We
searched PubMed, Embase, and the Cochrane Library for systematic reviews
and/or meta-analyses (SRs) of randomized controlled trials (RCTs) aimed
at evaluating drug therapy for GIOP. Both the methodo...
Source: Hormone and Metabolic Research - July 31, 2023 Category: Endocrinology Authors: Liang, Haodong Zhao, Jinlong Tian, Tianzhao Tags: Review Source Type: research
The Role of NF- κB, PPAR-α, and PPAR-γ in
Older Adults with Metabolic Syndrome
Horm Metab Res DOI: 10.1055/a-2109-1958The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood
yet, and chronic low-grade inflammation is thought to be associated with the
development of complications related to MetS. We aimed to investigate the role
of Nuclear factor Kappa B ( NF-κB ), Peroxisome Proliferator-Activated
Receptor- α and γ (PPAR-α, and PPAR-γ) which are
the main markers of inflammation in older adults with MetS. A total of 269
patients aged≥18, 188 patients with MetS who met the diagnostic criteria
of the Int...
Source: Hormone and Metabolic Research - July 19, 2023 Category: Endocrinology Authors: Demirda ğ, Filiz Yavuzer, Serap Cengiz, Mahir Yavuzer, Hakan Kara, Zehra Ayvac ı, Adnan Avc ı, Suna Y ürüyen, Mehmet Uzun, Hafize Alt ıparmak, Mehmet Rıza D öventaş, Alper Erdin çler, Deniz Suna Tags: Original Article: Endocrine Research Source Type: research
Prognostic Value of hsa_circ_0007615 in Epithelial Ovarian Cancer and
its Regulatory Effect on Tumor Progression
This study aimed to interrogate the functional and clinical significance of
hsa_circ_0007615 in epithelial ovarian cancer (EOC). GSE192410 was screened for
upregulated circRNAs in ovarian cancer. The expression levels of
hsa_circ_0007615 were evaluated in a patient cohort comprising 113 EOC tissues
and matched normal tissues. Subsequently, the prognostic value was confirmed by
the relevance of hsa_circ_0007615 with clinical parameters, Kaplan–Meier
analysis and Cox proportional risk model. Cell functional analyses were
performed in EOC cell lines using...
Source: Hormone and Metabolic Research - July 17, 2023 Category: Endocrinology Authors: Wei, Wei Wang, Ning Lin, Lin Tags: Original Article: Endocrine Research Source Type: research
A Study on the Clinical Significance of Blood Exosomal PD-L1 in
Non-Small Cell Lung Cancer Patients and its Correlation with PD-L1 in Tumor
Tissues
Horm Metab Res DOI: 10.1055/a-2110-7497Exosomal programmed cell-death ligand 1 (ePD-L1) can influence immune inhibition
and dysfunction. We were dedicated to unearthing the relation between ePD-L1 in
blood and pathological characteristics as well as PD-L1 in tumor tissues. We
recruited 65 non-small cell lung cancer (NSCLC) patients for exosome extraction
and detected the blood ePD-L1 expression in these patients by enzyme-linked
immunosorbent assay (ELISA) method. Besides, the correlation between blood
ePD-L1 and patients’ pathological characteristics was also a...
Source: Hormone and Metabolic Research - July 17, 2023 Category: Endocrinology Authors: Cheng, Yonghong Chang, Feiyun Gong, Yanmei Lu, Ping Tags: Original Article: Endocrine Research Source Type: research
Metabolomic Profile of Insulin Resistance Women with Systemic Lupus
Erythematosus
Horm Metab Res 2023; 55: 487-492 DOI: 10.1055/a-2093-0260The aims of this study were in systemic lupus erythematosus (SLE) patients: 1) to
compare the metabolomic profile of insulin resistance (IR) with controls and 2)
to correlate the metabolomic profile with other IR surrogates and SLE disease
variables and vitamin levels. In this cross-sectional study, serum samples were
collected from women with SLE (n=64) and gender- and age-matched
controls (n=71), which were not diabetic. Serum metabolomic profiling
was performed using UPLC-MS-MS (Quantse score). HOMA and Q...
Source: Hormone and Metabolic Research - July 10, 2023 Category: Endocrinology Authors: Mungu ía-Realpozo, Pamela Mendoza-Pinto, Claudia Etchegaray-Morales, Ivet Osorio-Pe ña, Angel David V élez-Pelcastre, Sandra Escamilla-M árquez, Marco Antonio Ay ón-Aguilar, Jorge M éndez-Martínez, Socorro Garc ía-Carrasco, Mario Tags: Original Article: Endocrine Care Source Type: research
Pulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal
Insufficiency
In conclusions, mimicking endogenous cortisol
rhythmicity by ultradian subcutaneous infusion of cortisol is feasible. It was
superior to both continuous pump and oral therapy in maintaining normal ACTH
levels throughout the 24-h cycle. Our results demonstrate a low free cortisol
bioavailability on thrice daily oral replacement therapy compared to both types
of subcutaneous infusion. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - July 10, 2023 Category: Endocrinology Authors: Simunkova, Katerina L øvås, Kristian Methlie, Paal Jovanovic, Nevena Bifulco, Ersilia Bronstad, Ingeborg Lightman, S. L. Husebye, Eystein Sverre Oksnes, Marianne Tags: Original Article: Endocrine Care Source Type: research
The Role of Alternative Lymph Node Classification Systems in
Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN): Superiority of a
LODDS Scheme Over N Category in Pancreatic NEN (pNEN)
Horm Metab Res 2023; 55: 452-461 DOI: 10.1055/a-2102-7694Lymph node (LN) involvement in gastroenteropancreatic neuroendocrine neoplasms
(GEP-NEN) has been reported to have prognostic and therapeutic implications.
Numerous novel LN classifications exist; however, no comparison of their
prognostic performance for GEP-NEN has been done yet. Using a nationwide cohort
from the German Neuroendocrine Tumor (NET) Registry, the prognostic and
discriminatory power of different LN ratio (LNR) and log odds of metastatic LN
(LODDS) classifications were investigated using multi...
Source: Hormone and Metabolic Research - July 10, 2023 Category: Endocrinology Authors: Krieg, Sarah Tunk, Johannes Vaghiri, Sascha Prassas, Dimitrios Jann, Henning Mohr, Raphael Loosen, Sven Heiko Roderburg, Christoph Maasberg, Sebastian Begum, Nehara Luedde, Tom Schott, Matthias Giesel, Frederik Knoefel, Wolfram Trudo Krieg, Andreas Tags: Original Article: Endocrine Care Source Type: research
Natural History of Non-Functioning Pituitary Adenomas: A Systematic
Review and Meta-Analysis
The objective of this systematic review
was to assess the risk of growth, new pituitary endocrinopathies, and surgery in
patients with conservatively treated NFPTs. We conducted a bibliographical
search identifying studies assessing NFPTs followed conservatively. Estimates
were pooled using random-effects meta-analysis reporting events per 100 person
years (PYs), in case of high heterogeneity (I2>75%) only the
range of observed effects was reported. We identified 30 cohort studies
including 1957 patients with a mean follow-up time of 4.0 (SD 1.5) year...
Source: Hormone and Metabolic Research - July 10, 2023 Category: Endocrinology Authors: Rikvold, Stefan Dukanovic Pedersen, Mathias Brown Andreassen, Mikkel Krogh, Jesper Tags: Original Article: Endocrine Care Source Type: research
Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising
Prognostic Factor for Thyroid Cancer
Horm Metab Res DOI: 10.1055/a-2111-3821Thyroid cancer is a tumor that occurs in the head and neck, which originates from
the thyroid follicular epithelial cells. The current research is discussed and
elaborated from the perspective of molecular prognostic biomarkers to gain a
deeper understanding of the molecular mechanism of thyroid cancer and to provide
more effective treatment and prognostic methods for patients. Thyroid cancer
patients were explored from histological, cellular and clinical levels.
Real-time quantitative polymerase chain reaction (RT-qPCR) was ...
Source: Hormone and Metabolic Research - July 6, 2023 Category: Endocrinology Authors: Hei, Guoli Yu, Yan Wu, Yang Huang, Jianyuan Tags: Original Article: Endocrine Research Source Type: research
Acute Glycemic Variability and Early Outcomes After Cardiac Surgery:
A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2106-5539The influence of acute glycemic variability (GV) on early outcomes of patients
after cardiac surgery remains not fully determined. We performed a systematic
review and meta-analysis to evaluate the association between acute GV and
in-hospital outcomes of patients after cardiac surgery. Relevant observational
studies were obtained by search of electronic databases including Medline,
Embase, Cochrane Library, and Web of Science. A randomized-effects model was
selected to pool the data by incorporating the influence of potential...
Source: Hormone and Metabolic Research - July 4, 2023 Category: Endocrinology Authors: Chang, Shuo Xu, Mian Wang, Yu Zhang, Yanbo Tags: Original Article: Endocrine Care Source Type: research
CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction
and Permeability Damage in Retinal Microvascular Endothelial
Cells
This study was designed to assess the role and mechanism of circRNA SCAR in human
retinal microvascular endothelial cells (hRMVECs) treated with high glucose.
Quantitative real-time polymerase chain reaction (qRT-PCR) and cell counting kit
8 (CCK-8) were used to detect the effects of different concentrations of glucose
on circRNA SCAR expression and cell proliferation in hRMVECs. Cell viability,
levels of oxygen species (ROS), malondialdehyde (MDA) and adenosine triphosphate
(ATP), as well as activities of antioxidant enzymes superoxide dismutase (SOD)
a...
Source: Hormone and Metabolic Research - July 3, 2023 Category: Endocrinology Authors: Wu, Rong Huang, Sheng Xie, Jin-feng Wen, Nian-lian Wen, Min Zhong, Su-e Tags: Original Article: Endocrine Research Source Type: research
Immune-Related Genes can Serve as Potential Biomarkers for Predicting
Severe Acute Pancreatitis
Horm Metab Res DOI: 10.1055/a-2105-6152We aimed to investigate immune-related candidate genes for predicting the
severity of acute pancreatitis (AP). RNA sequencing profile GSE194331 was
downloaded, and differentially expressed genes (DEGs) were investigated.
Meanwhile, the infiltration of immune cells in AP were assessed using CIBERSORT.
Genes related with the infiltration of immune cells were investigated using
weighted gene co-expression network analysis (WGCNA). Furthermore, immune
subtypes, micro-environment, and DEGs between immune subtypes were explored.
...
Source: Hormone and Metabolic Research - June 30, 2023 Category: Endocrinology Authors: Zhao, Weijuan Tags: Original Article: Endocrine Research Source Type: research
