Incretins Enhance PGF2 α-Induced Synthesis of IL-6
and Osteoprotegerin in Osteoblasts
Horm Metab Res 2022; 54: 42-49 DOI: 10.1055/a-1713-7967Incretins including glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1), which are secreted from the small intestine
after oral food ingestion, are currently well-known to stimulate insulin
secretion from pancreatic β-cells and used for the treatment of type 2
diabetes mellitus. We have previously reported that prostaglandin
F2α (PGF2α) stimulates the synthesis
of interleukin-6 (IL-6) and osteoprotegerin in osteoblast-like MC3T3-E1 cells,
and that IL-6 and oste...
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Authors: Hioki, Tomoyuki Kuroyanagi, Gen Fujita, Kazuhiko Sakai, Go Kawabata, Tetsu Kim, Woo Tachi, Junko Matsushima-Nishiwaki, Rie Iida, Hiroki Kozawa, Osamu Tokuda, Haruhiko Tags: Endocrine Research Source Type: research
The Triglycerides and Glucose Index is Negatively Associated with
Insulin Secretion in Young Adults with Normal Weight
Horm Metab Res 2022; 54: 33-36 DOI: 10.1055/a-1713-7821Several studies have supported the usefulness of the triglycerides and glucose
(TyG) index as a surrogate measure of insulin resistance; however, it has not
been evaluated in insulin secretion. The aim of this study was to assess the
association between the TyG index and insulin secretion in young adults with
normal weight. Apparently healthy non-pregnant women and men, aged 18 to 23
years, were enrolled in a cross-sectional study. Overweight, obesity, pregnancy,
smoking, alcohol consumption, diabetes, liver d...
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Authors: Simental-Mend ía, Luis E. G ómez-Díaz, Rita Wacher, Niels H. Guerrero-Romero, Fernando Tags: Endocrine Care Source Type: research
Effects of Long-Acting Somatostatin Analogues on Lipid Metabolism in
Patients with Newly Diagnosed Acromegaly: A Retrospective Study of 120
Cases
In conclusion, our current study
revealed that short-term SSAs treatment improves lipid profiles and other
cardiovascular risk factors in patients with acromegaly. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Authors: Shao, Xiao-qing Chen, Zheng-yuan Wang, Meng Yang, Ye-ping Yu, Yi-fei Liu, Wen-juan Wang, Yi Zeng, Fang-fang Gong, Wei Ye, Hong-ying Wang, Yong-fei Zhao, Yao Zhang, Li Zhang, Zhao-yun He, Min Li, Yi-ming Tags: Endocrine Care Source Type: research
Glucocorticoids Increase Fracture Risk and Fracture Prevalence
Independently from Bone Mineral Density and Clinical Risk Factors: Results from
the Gliwice Osteoporosis (GO) Study
In conclusion, in patients treated
with GCs the fracture risk, probability, and prevalence were increased. This
effect was evident regardless of whether GC therapy is included in the algorithm
as a risk factor (FRAX, POL-RISK) or not taken into consideration (Garvan
nomogram). [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Authors: Pluskiewicz, Wojciech Adamczyk, Piotr Drozdzowska, Bogna Tags: Endocrine Care Source Type: research
The Association of Thyroid Hormones with Coronary Atherosclerotic
Severity in Euthyroid Patients
Horm Metab Res 2022; 54: 12-19 DOI: 10.1055/a-1718-6283The aim of the work was to explore the correlation between thyroid hormones and
coronary atherosclerotic severity. This cross-sectional study included 340
euthyroid patients who underwent diagnostic coronary artery angiography (CAG).
Gensini Score (GS) was applied to assess the severity of coronary
atherosclerosis. Thyroid hormones and routine biochemical parameters were
measured. The associations between thyroid hormones and coronary atherosclerosis
severity were analyzed. Thyroid hormones levels or parameter...
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Authors: Yu, Na Wang, Linjie Zeng, Yong Zhao, Yuxing Chen, Shi Pan, Hui Gong, Fengying Zhu, Huijuan Tags: Endocrine Care Source Type: research
Thanks to the Reviewers
Horm Metab Res 2022; 54: 5-6 DOI: 10.1055/a-1688-1738 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 5, 2022 Category: Endocrinology Tags: Editorial Source Type: research
Serum Irisin and Diabetic Nephropathy in Patients with Diabetes Mellitus
Horm Metab Res 2021; 53: 825-825 DOI: 10.1055/a-1676-4118Dear Editor,I read the article by Wang et al., who conducted a meta-analysis to investigate the association between serum irisin levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM) 1. The mean serum irisin level in T2DM patients with microalbuminuria was significantly lower than that in T2DM patients with normoalbuminuria. In addition, the mean serum irisin level in T2DM patients with macroalbuminuria was significantly lower than that in T2DM patients with microalbuminuria. Furthermore, the mean serum irisin level in T2DM patients wi...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Kawada, Tomoyuki Tags: Letter to the Editor Source Type: research
Long Non-Coding RNA Small Nucleolar RNA Host Gene 5 (SNHG5) Regulates
Renal Tubular Damage in Diabetic Nephropathy via Targeting
MiR-26a-5p
This study recruited 62 types 2 diabetes mellitus (T2DM) patients, 58 DN
patients and 60 healthy controls (HC). The expressions of serum SNHG5 and
miR-26a-5p were measured by RT-qPCR analysis. The diagnostic value of SNHG5 in
DN was assessed by ROC curve. The in vitro cell model was built to estimate the
effects of SNHG5 on cell viability, cell apoptosis, inflammation response and
oxidative stress. Serum SNHG5 was increased in DN patients (relative expression:
2.04±0.34) and had the diagnostic value in DN. After HK2 cells were
treated with high glucose,...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Cai, Qing Wang, Chao Huang, Li Wu, Chen Yan, BingChao Chen, Ting Li, Qinjun Wang, Ling Tags: Endocrine Research Source Type: research
Plasma Hemoglobin and Red Blood Cell Mass Levels as Dynamic Prognostic Markers for Progression and Survival in Pancreatic Neuroendocrine Tumors
In conclusion, decrease in red blood cells mass, hemoglobin and/or hematocrit levels are all associated with poor prognosis in patients with pancreatic neuroendocrine tumors. We suggest utilizing these parameters as complementary follow-up prognostic markers to radiologic imaging in this patients population. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Halperin, Reut Ahron-Hananel, Genya Badarna, Muhamad Greidinger, Dahlia Uri, Inbal Percik, Ruth Tirosh, Amit Tags: Endocrine Care Source Type: research
Association Between Prediabetes and Retinopathy: A
Meta-Analysis
Horm Metab Res 2021; 53: 801-809 DOI: 10.1055/a-1678-7092Diabetes confers an increased risk of microvascular complications, including
retinopathy. However, whether prediabetes is also related to retinopathy has not
been comprehensively examined. We performed a meta-analysis to evaluate the
relationship between prediabetes and retinopathy. This meta-analysis included
relevant observational studies from Medline, Embase, and Web of Science
databases. A random-effect model after incorporation of the intra-study
heterogeneity was selected to pool the results. Subgroup ...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Jin, Ji Lu, Peirong Tags: Endocrine Care Source Type: research
Sunitinib-Induced Hypothyroidism and Survival in Pancreatic Neuroendocrine Tumors
This study assessed whether sunitinib-induced hypothyroidism is a predictive marker of the objective response rate, progression-free survival, and overall survival in pancreatic neuroendocrine tumor patients. Twenty-nine patients treated with sunitinib for advanced pancreatic neuroendocrine tumors were included. The incidence of sunitinib-induced hypothyroidism was 33%. The median progression-free survival of patients who developed hypothyroidism was 16 months (95% confidence interval: 6.2–25.8 months) as compared with six months among euthyroid patients (95% confidence interval: 0.1–12.2 months) (p=0.02). The median o...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Mathew, Annie F ührer, Dagmar Lahner, Harald Tags: Endocrine Care Source Type: research
Incidence of Primary Aldosteronism in Patients with Hypokalemia
(IPAHK+): Study Design and Baseline
Characteristics
Horm Metab Res 2021; 53: 787-793 DOI: 10.1055/a-1685-0583Hypokalemia plays a central role for case finding, course, treatment decision,
and prognosis of patients with primary aldosteronism. However, to date there is
a lack of high-level evidence about the incidence of primary aldosteronism in
hypokalemic patients. The IPAHK+study is an epidemiological,
cross-sectional, monocentric study to provide evidence on the incidence of PA in
a hypokalemic population. The aim of the current analysis was to describe the
baseline characteristics of the first 100 patients eligi...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Gruber, Sven Stasi, Evangelia Steiner, Regula Reincke, Martin Bornstein, Stefan Beuschlein, Felix Tags: Endocrine Care Source Type: research
Effects of Lipid Overload on Heart in Metabolic
Diseases
Horm Metab Res 2021; 53: 771-778 DOI: 10.1055/a-1693-8356Metabolic diseases are often associated with lipid and glucose metabolism
abnormalities, which increase the risk of cardiovascular disease. Diabetic
cardiomyopathy (DCM) is an important development of metabolic diseases and a
major cause of death. Lipids are the main fuel for energy metabolism in the
heart. The increase of circulating lipids affects the uptake and utilization of
fatty acids and glucose in the heart, and also affects mitochondrial function.
In this paper, the mechanism of lipid overload in me...
Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Yan, An Xie, Guinan Ding, Xinya Wang, Yi Guo, Liping Tags: Review Source Type: research
Novel Classification of Acromegaly in Accordance with
Immunohistochemical Subtypes: Is There Really a Clinical
Relevance?
In conclusion, classification according to immunohistochemical
subtypes of growth hormone secreting adenomas may not be a qualified parameter
to evaluate patients with patterns of aggressiveness, clinical outcomes, or
treatment response. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 29, 2021 Category: Endocrinology Authors: Akkus, Gamze Odaba ş, Fulya S özütok, Sinan Sert, Murat Ak, Numan Emre Evran, Mehtap Tetiker, Tamer Tags: Endocrine Care Source Type: research
Risk Patterns of Distant Metastases in Follicular, Papillary and
Medullary Thyroid Cancer
This study of 542 patients with follicular thyroid cancer, 366 patients with the
follicular variant and 1452 patients with the classical variant of papillary
thyroid cancer, and 819 patients with sporadic medullary thyroid cancer operated
at a tertiary referral center aimed to determine risk patterns of distant
metastasis for each tumor entity, which are ill-defined. On multivariable
logistic regression analyses, lymph node metastasis consistently emerged as an
independent risk factor of distant metastasis, yielding odds ratios (ORs) of 2.4
and 2.8 for f...
Source: Hormone and Metabolic Research - November 10, 2021 Category: Endocrinology Authors: Machens, Andreas Lorenz, Kerstin Weber, Frank Dralle, Henning Tags: Endocrine Care Source Type: research
