LncRNA LINC01018 Screens Type 2 Diabetes Mellitus and Regulates β Cell Function Through Modulating miR-499a-5p
This study aimed to confirm the abnormal expression of LINC01018 in
T2DM and reveals its specific function in regulating pancreatic β cell
function. This study enrolled 77 T2DM patients and 41 healthy individuals and
compared the plasma LINC01018 levels between two groups using PCR. The
pancreatic β cell was induced with 25 mM glucose to mimic cell
injury during T2DM. The effects of LINC01018 on β cell proliferation,
dedifferentiation, and insulin production were evaluated by CCK8, western
blotting, and ELISA. Moreover, the involvement of miR-499a-5...
Source: Hormone and Metabolic Research - May 15, 2023 Category: Endocrinology Authors: Liu, Li Li, Yuan Zhang, Xiaoqian Tags: Original Article: Endocrine Research Source Type: research
Does the Association of Hashimoto's Thyroiditis with
Differentiated Thyroid Cancer Really Have a Protective Role?
Horm Metab Res DOI: 10.1055/a-2065-0845The study is an investigation of aggressive tumor features, prognosis, and
disease-specific mortality rates of differentiated thyroid cancer (DTC) in the
presence of concomitant Hashimoto’s Thyroiditis (HT). The data of
patients with DTC followed in our tertiary care center between 2000–2022
were analyzed. Variables such as patient age, gender, preoperative serum
autoantibody levels, tumor characteristics, and treatment modalities were
obtained from medical records. The diagnosis of HT was based either on the
pr...
Source: Hormone and Metabolic Research - May 9, 2023 Category: Endocrinology Authors: Demir, Ahmet Numan Kara, Zehra Sulu, Cem Uysal, Serhat Sahin, Serdar Zulfaliyeva, Guldana Atar, Oznur Aydin Valikhanova, Nahida Ozturk, Tulin Ozkaya, Hande Mefkure Gonen, Mustafa Sait Tags: Original Article: Endocrine Care Source Type: research
Metabolic-Related Index to Predict Post-Transplantation Diabetes
Mellitus After Kidney Transplantation
This article aims to explore the convenient and inexpensive
values of metabolic-related markers, including TyG, TyG-BMI, TG/HDL-C,
and non-HDL-C/HDL-C for predicting PTDM. The data of 191 kidney
transplant recipients in our center were collected retrospectively. The
association between TyG, TyG-BMI, TG/HDL-C, non-HDL-C/HDL-C and
the risk of PTDM was examined by the area under the curve and logistic
regression analyses. During 6 months follow-up, 12.04% of KT recipients
developed PTDM, and significantly higher values of TyG-BMI, TyG, and
non-HDL...
Source: Hormone and Metabolic Research - May 2, 2023 Category: Endocrinology Authors: Xiaojie, Ni Bicheng, Chen Yongling, Li Tingting, Huang Yi, Zhou Chen, Zimiao Tags: Original Article: Endocrine Care Source Type: research
Risk Factors for Lymph Node Metastasis in Papillary Thyroid
Carcinoma: A Retrospective Study
This study was aimed to
investigate the risk factors of various types of LNM in PTC with tumor
diameter>1 cm. The clinical data of 2216 PTC patients were
retrospectively analyzed. Univariate and multivariate logistic regression models
were used to analyze the risk factors of LNM. In addition, the receiver operator
characteristic (ROC) curve was used to find the best cut-off value of CLNM for
predicting LLNM. Finally, the independent risk factors of LLNM were used to
construct the prediction of LLNM nomogram. Age≤55 years old, male,
bilat...
Source: Hormone and Metabolic Research - May 2, 2023 Category: Endocrinology Authors: Gong, Jiantao Zhu, Baining Liu, Wenji Shi, Chaoqun Xia, Chen Zeng, Liqin Lv, Yunxia Tags: Original Article: Endocrine Care Source Type: research
Consequence of Dementia and Cognitive Impairment by Primary
Nucleation Pathway
Horm Metab Res 2023; 55: 304-314 DOI: 10.1055/a-2052-8462An acquired loss of cognition in several cognitive domains that is severe enough
to interfere with social or professional functioning is called dementia. As well
as a moderately in-depth mental status examination by a clinician to identify
impairments in memory, language, attention, visuospatial cognition, such as
spatial orientation, executive function, and mood, the diagnosis of dementia
requires a history evaluating for cognitive decline and impairment in daily
activities, with confirmation from a close f...
Source: Hormone and Metabolic Research - May 2, 2023 Category: Endocrinology Authors: Singh, Aditya Ansari, Vaseem Ahamad Ansari, Tarique Mahmood Hasan, Syed Misabah Ahsan, Farogh Singh, Kuldeep Wasim, Rufaida Maheshwari, Shubhrat Ahmad, Asad Tags: Review Source Type: research
Detailed Review on Gestational Diabetes Mellitus with Emphasis on
Pathophysiology, Epidemiology, Related Risk Factors, and its Subsequent
Conversion to Type 2 Diabetes Mellitus
Horm Metab Res 2023; 55: 295-303 DOI: 10.1055/a-2061-9441Any degree of glucose intolerance during the pregnancy of a women is termed as
Gestational Diabetes Mellitus (GDM). It may further develop into Type 2 Diabetes
Mellitus (T2DM) later in life. GDM affects both mother and infant in multiple
ways and there are various factors that predispose the development of GDM.The
primary objective of this review is to describe the various aspects related to
GDM and the subsequent risk of developing T2DM later in life.We reviewed freely
accessible, full-text articles, availa...
Source: Hormone and Metabolic Research - May 2, 2023 Category: Endocrinology Authors: Gajera, Dhruvil Trivedi, Vishva Thaker, Priyanshu Rathod, Mrudang Dharamsi, Abhay Tags: Review Source Type: research
Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of
Prostate Cancer Cells
Horm Metab Res DOI: 10.1055/a-2065-0954MicroRNAs (miRNAs) have been discovered to play critical role in regulating
prostate cancer (PC) progression. The function role of miR-629 in tumor
progression of PC has not been studied. Here, we found that miR-629 was markedly
upregulated in PC as determined using the cancer genome atlas (TCGA) dataset,
clinical tissues, and cell lines. Functional analysis (MTT assays, colony
formation assays, soft agar growth assay and BrdU incorporation assay) indicated
that overexpression of miR-629 was drastically promoted, while miR-62...
Source: Hormone and Metabolic Research - April 28, 2023 Category: Endocrinology Authors: Li, Yuqiao Zeng, Sha Cao, Longbin Tags: Original Article: Endocrine Research Source Type: research
Association Between Papillary Thyroid Carcinoma and Vertebral
Fracture
Horm Metab Res DOI: 10.1055/a-2059-8830Suppression of TSH levels associated with levothyroxine treatment is a known risk
factor for fracture. However, it is unclear whether patients with papillary
thyroid carcinoma (PTC) have a higher risk of vertebral fracture (VF) before TSH
suppression. The aim of the study was to examine whether the risk of VF is
higher in PTC than in healthy subjects. A hospital-based, matched case-control
study was conducted comparing PTC and healthy individuals. We enrolled 43
postoperative patients with PTC scheduled for radioiodine therap...
Source: Hormone and Metabolic Research - April 17, 2023 Category: Endocrinology Authors: Otani, Hazuki Notsu, Masakazu Yamauchi, Mika Nawata, Kiyoko Kanasaki, Keizo Tags: Original Article: Endocrine Care Source Type: research
The “Non-Treated” Versus
“LT3-Treated” Protocols of Short-Term Hypothyroidism Induction
in Differentiated Thyroid Cancer: An Analysis of Hypothyroid Complications, Mood
Disorders, and Quality of Life
In conclusion, our findings indicate the
likelihood of L3-treatment to enable a more favorable transition period from
euthyroid to hypothyroid state without experiencing a deterioration in
depression, anxiety, or HRQoL. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 14, 2023 Category: Endocrinology Authors: Tufekci, Damla Ayaz, Teslime Sahin, Serap Baydur Hocaoglu, Cicek Tags: Original Article: Endocrine Care Source Type: research
Do Histologically Aggressive Subtypes of Papillary Thyroid
Microcarcinoma have Worse Clinical Outcome than Non-Aggressive Papillary Thyroid
Microcarcinoma Subtypes? A Multicenter Cohort Study
In this study, we intended to determine the difference in clinical
outcomes between patients with aggressive and non-aggressive PTMC subtypes. In
this multicenter cohort study, the computer-recorded clinical and
histopathological data of patients who underwent thyroid surgery between January
2000 - January 2021 in 9 referral centers and were diagnosed as PTMC were
analyzed. A total of 1585 patients [female 1340 (84.5%), male 245
(15.5%), mean age 47.9±11.63 years), with a mean follow-up time
of 66.55±37.16 months], were included in the study. Ninety-ei...
Source: Hormone and Metabolic Research - April 6, 2023 Category: Endocrinology Authors: Zuhur, Sayid Shafi Aggul, Hunkar Avci, Ugur Erol, Selvinaz Tuna, Mazhar M üslüm Uysal, Serhat Akbaba, Gulhan Kilin ç, Faruk Catak, Merve Tekin, Sakin Bilen, Ogun Irem Öztürk, Beyza Olcay Erden, Ecem Bilgehan Elbuken, Gulsah Yavuz, Halise Cinar Kadiog Tags: Original Article: Endocrine Care Source Type: research
CCND1-Induced Autophagy Contributes to Lymph Node Metastasis in
Endometrial Cancer
Horm Metab Res DOI: 10.1055/a-2044-9227Endometrial cancer with lymph node metastasis shows poor prognosis, while the
biomarker to predict the metastasis is lacking. The relative mRNA or protein
expression of cyclin D1 (CCND1) and autophagy-related molecules were detected in
real-time PCR and Western blot. Correlation analysis was applied to identify any
significant patterns, and receiver operating characteristics (ROC) was performed
to assess the prediction value. CCND1 vector was transfected in Ishikawa (ISK)
cells, and the relative expression of autophagy-relate...
Source: Hormone and Metabolic Research - April 5, 2023 Category: Endocrinology Authors: Su, Yi Zhou, Haonan Ma, Zhao Liu, Jing Li, Chen Tags: Original Article: Endocrine Research Source Type: research
Circulating Asprosin Concentrations in Patients with Obesity and
Carbohydrate Disturbances
Horm Metab Res 2023; 55: 284-289 DOI: 10.1055/a-2033-6109Asprosin is a fasting-induced glucogenic hormone, secreted by white adipose
tissue in response to starvation. The aim of the current study was to determine
the levels of asprosin in subjects from the entire spectrum of the carbohydrate
metabolism. A total of 153 Causcasian subjects participated in this study: group
1, healthy volunteers; group 2, obese subjects without glycemic disturbances;
group 3, subjects with prediabetes and group 4, patients with newly identified
type 2 diabetes. Subject with body mass...
Source: Hormone and Metabolic Research - April 5, 2023 Category: Endocrinology Authors: Nedeva, Iveta Slavyanova Assyov, Yavor Karamfilova, Vera Vodenicharov, Vlayko Gerganova, Antonina Hristova, Julieta Kamenov, Zdravko Tags: Original Article: Endocrine Research Source Type: research
Reduced Health Related Quality of Life, Increased Fatigue, and
Daytime Sleepiness in Women with Hyperprolactinemia
Horm Metab Res 2023; 55: 266-272 DOI: 10.1055/a-2042-0712Prolactin has many physiological effects and seems to be involved in the human
quality of life and well-being. The aim of this study was to describe health
related quality of life, fatigue and daytime sleepiness in women with untreated
hyperprolactinemia. In total 32 women (mean age 37.0±10.9 years) with
verified hyperprolactinemia completed a questionnaire including questions on
fatigue, measured with the Swedish version of the Fatigue Impact Scale (FIS),
propensity to fall in sleep, measured with the Swed...
Source: Hormone and Metabolic Research - April 5, 2023 Category: Endocrinology Authors: Ernersson, Åsa Bachrack-Lindstr öm, Margareta Landberg, Eva Ekman, Bertil Wahlberg, Jeanette Tags: Original Article: Endocrine Care Source Type: research
Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children
This study investigates whether serum prolactin (PRL) is a key factor for
nonalcoholic fatty liver disease (NAFLD) in children. A total of 691 obese
childred participated in this study and were divided into a NAFLD group
(n=366) and simple obesity (SOB) group (n=325) according to the
hepatic ultrasound results. The two groups were matched for gender, age,
pubertal development, and body mass index (BMI). All patients underwent an OGTT
test, and fasting blood samples were collected to measure prolactin. Stepwise
logistic regression was performed to identif...
Source: Hormone and Metabolic Research - April 5, 2023 Category: Endocrinology Authors: Zhang, Jianwei Guan, Jieqiong Tang, Xiaoli Xu, Jinliang Tags: Original Article: Endocrine Care Source Type: research
A Revised Version of the TNM Classification Leads to Optimized
Predictive Performance in Patients with Adrenocortical Carcinoma
In conclusion, the present study demonstrates that
updating the current staging system with revised T1 and T2 categories
significantly improves the prediction of cancer-specific survival (CSS) in
patients with ACC. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 5, 2023 Category: Endocrinology Authors: David, Stephan Oliver Krieg, Sarah Esposito, Irene Schott, Matthias Giesel, Frederik Lars Roderburg, Christoph Loosen, Sven Heiko Luedde, Tom Knoefel, Wolfram Trudo Krieg, Andreas Tags: Original Article: Endocrine Care Source Type: research
