Preoperative Serum Thyroglobulin Levels Predict Radioiodine Therapy Outcome in Papillary Thyroid Microcarcinoma Patients
Horm Metab Res DOI: 10.1055/a-2291-0340Our previous study showed that elevated preoperative thyroglobulin (pre-Tg) level
predicted the risk of developing radioiodine refractory in PTC patients. In the
present study, we aimed to evaluate the prognostic value of pre-Tg in papillary
thyroid microcarcinoma (PTMC). After a specific inclusion and exclusion criteria
were applied, a total of 788 PTMCs were enrolled from Jiangyuan Hospital
affiliated to Jiangsu Institute of Nuclear Medicine between Jan 2015 and Dec
2019. Among them, 107 PTMCs were treated with radioiodine therapy (RAIT) and the
response to therapy was grouped as excellent response (ER), and non-excellent
response (NER: indeterminate response, IDR and biochemical incomplete response,
BIR). Multivariable logistic regression was used to identify predictors for the
response of RAIT in PTMCs. Higher pre-Tg levels were detected in PTMCs with RAIT
as compared with PTMCs without RAIT (p=0.0018). Higher levels of pre-Tg were
also found in patients with repeated RAIT as compared with patients with single
RAIT (p<0.0001). Furthermore, pre-Tg level was higher in PTMC with IDR (n=16)
and much higher in BIR (n=9) as compared with patients with ER (n=82, p=0.0003)
after RAIT. Multivariate analysis showed that pre-Tg level over 16.79 ng/ml [OR:
6.55 (2.10–20.39), p=0.00...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Cheng, Xian Fan, Yijun Ye, Wanzhong Xu, Shichen Wu, Jing Gao, Wenjing Bao, Jiandong Yu, Huixin Zhang, Li Tags: Original Article: Endocrine Care Source Type: research
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