Th17 Cell-Related Gene Biomarkers in Osteoporosis: Comprehensive
Bioinformatics Analysis and In Vivo Validation
Horm Metab Res DOI: 10.1055/a-2196-7811The interaction between the bone and immune systems has a major role in
osteoporosis regulation. However, the infiltration of T helper 17 (Th17) cells
and their associated genes in osteoporosis remains unclear. The GSE35959 dataset
was obtained from the Gene Expression Omnibus (GEO) database, and the Immune
Cell Abundance Identifier (ImmuCellAI) program was used to evaluate the
abundance of 24 immune cell types, including Th17 cells. Differential analysis
and relevance analysis were performed to identify differentially expres...
Source: Hormone and Metabolic Research - November 17, 2023 Category: Endocrinology Authors: Chen, Jianxing Sun, Qifeng Yin, Wenzhe Tags: Original Article: Endocrine Research Source Type: research
Mechanistic Insights into Ferroptotic Cell Death in Pancreatic
Islets
In this study, we
aimed to elucidate the mechanism of ferroptosis in pancreatic islets. Using a
rodent model, isolated islets were characterized relating to the effects of
experimental induction (RSL3) and inhibition (Fer1) of ferroptotic pathways.
Besides viability, survival, and function, the study focused on characteristic
ferroptosis-associated intracellular changes such as MDA level, iron
concentration and the expression of ACSL4. The study demonstrates that
pharmaceutical induction of ferroptosis by RSL3 causes enhancement of oxidative
st...
Source: Hormone and Metabolic Research - November 13, 2023 Category: Endocrinology Authors: Schepp, Florian Schubert, Undine Schmid, Janine Lehmann, Susann Latunde-Dada, Gladys Oluyemisi Kose, Tugba Steenblock, Charlotte Bornstein, Stefan R. Linkermann, Andreas Ludwig, Barbara Tags: Original Article: Endocrine Research Source Type: research
LINC00092 Enhances LPP Expression to Repress Thyroid Cancer
Development via Sponging miR-542-3p
This study aimed to reveal the role and
regulatory mechanism of LINC00092 in TC.RNA immunoprecipitation and dual luciferase reporter assays were employed to
ascertain the relationships among lipoma preferred partner (LPP), miR-542-3p,
and LINC00092. qRT-PCR analysis was performed to detect their expression levels
in TC. LPP protein productions were evaluated via western blotting. CCK-8,
transwell, and colony formation assays were done to estimate TC cells’
biological functions. A murine xenograft model was built to observe tumor
formation in vivo.LINC0...
Source: Hormone and Metabolic Research - November 7, 2023 Category: Endocrinology Authors: Wang, Huan Tags: Original Article: Endocrine Research Source Type: research
Association Between Metabolic Syndrome and the Risk of Lung Cancer: A
Meta-Analysis
In conclusion, in
adult population, MetS may be a risk factor of lung cancer incidence and
mortality. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 2, 2023 Category: Endocrinology Authors: Zhang, Zhao Liu, Qinxiang Huang, Congcong Wu, Jun Wen, Yingsheng Tags: Original Article: Endocrine Care Source Type: research
On Primary Adrenal Insufficiency with Normal Concentrations of
Cortisol – Early Manifestation of Addison’s
Disease
Horm Metab Res DOI: 10.1055/a-2180-7108Primary adrenal insufficiency (AI) is an endocrine disorder in which hormones of
the adrenal cortex are produced to an insufficient extent. Since receptors for
adrenal steroids have a wide distribution, initial symptoms may be nonspecific.
In particular, the lack of glucocorticoids can quickly lead to a
life-threatening adrenal crisis. Therefore, current guidelines suggest applying
a low threshold for testing and to rule out AI not before serum cortisol
concentrations are higher than 500 nmol/l (18 μg/dl). To
ease ...
Source: Hormone and Metabolic Research - November 2, 2023 Category: Endocrinology Authors: W äscher, Hanna Knauerhase, Andreas Klar, Bettina Postrach, Till Weber, Marc-Andr é Willenberg, Holger Sven Tags: Original Article: Endocrine Care Source Type: research
The Impact of the COVID Pandemic on Adrenal Surgery at an Academic
Endocrine Surgery Unit
Horm Metab Res 2023; 55: 765-770 DOI: 10.1055/a-2187-3547COVID-19 has severely affected the delivery of surgical care worldwide. The aim
of the present study was to evaluate its impact on adrenal surgery at our
academic endocrine center. All primary adrenal surgeries performed at the
University Hospital of Cologne, Germany between 01.01.2019 and 31.07.2022 were
included. This time frame was divided into pre-Covid (before 02/20),
acute Covid (until 05/21), and post acute period (after
05/2021). Demographics, clinic-pathologic characteristics and treatment
...
Source: Hormone and Metabolic Research - October 30, 2023 Category: Endocrinology Authors: Chiapponi, Costanza Faust, Michael Schmidt, Matthias Schier, Robert Thomas, Michael Stippel, Dirk L. Bruns, Christiane Josephine Alakus, Hakan Tags: Original Article: Endocrine Care Source Type: research
The Associations of Maternal Blood Hemoglobin and Serum Triglyceride
Levels and the Risk of Preterm Delivery
Horm Metab Res 2023; 55: 758-764 DOI: 10.1055/a-2183-8683The abnormal hemoglobin (HGB) and serum lipid concentrations during pregnancy
will increase the risk of preterm delivery. Our study aimed to explore the
correlation between prenatal HGB and serum lipid levels and preterm delivery. We
enrolled 215 mother-infant pairs in a pilot cohort study. The logistic
regression model and Restricted Cubic Spline model (RCS) were used to
investigate the levels of prenatal blood HGB and serum lipid such as
triglyceride (TG), total cholesterol, high-density lipoprotein, low d...
Source: Hormone and Metabolic Research - October 30, 2023 Category: Endocrinology Authors: Song, Xia Lin, Jiujing Dong, Xiaoxiao Li, Mengyun Xue, Xiangsheng Hou, Chenyang Yao, Huichen Hou, Qingzhi Tags: Original Article: Endocrine Care Source Type: research
Graves ’ Orbitopathy Models: Valuable Tools for Exploring
Pathogenesis and Treatment
Horm Metab Res 2023; 55: 745-751 DOI: 10.1055/a-2161-5417Graves’ orbitopathy (GO) is the most common extrathyroidal complication
of Graves’ disease (GD) and severely affects quality of life. However,
its pathogenesis is still poorly understood, and therapeutic options are
limited. Animal models are important tools for preclinical research. The animals
in some previous models only exhibited symptoms of hyperthyroidism without
ocular lesions. With the improvements achieved in modeling methods, some
progressive animal models have been established. Immunization of...
Source: Hormone and Metabolic Research - October 30, 2023 Category: Endocrinology Authors: Wang, Ling Zhang, Meng Wang, Yue Shi, Bingyin Tags: Review Source Type: research
Salt and Aldosterone – Reciprocal and Combined Effects in
Preclinical Models and Humans
Horm Metab Res DOI: 10.1055/a-2172-7228Primary aldosteronism is an endocrine disorder caused by excessive production of
aldosterone by the adrenal glands, and is recognized as the most important cause
of endocrine hypertension. With specific therapy, this type of hypertension is
potentially curable. In the general population, high salt intake increases the
risk for cardiovascular diseases like stroke. In populations with aldosterone
excess, observational and experimental data suggest that aldosterone-induced
organ damage requires a combination of high dietary salt...
Source: Hormone and Metabolic Research - October 27, 2023 Category: Endocrinology Authors: Chen, Li Adolf, Christian Reincke, Martin Schneider, Holger Tags: Review Source Type: research
LncRNA LINC01339 Hinders the Development of Wilms ’ Tumor via
MiR-135b-3p/ADH1C Axis
This study intended to investigate how a novel long non-coding
RNA LINC01339 functions in the pathogenesis of Wilms’ tumor. An elevated
miR-135b-3p expression as well as reduced levels of LINC01339 and ADH1C were
observed in Wilms’ tumor. LINC01339 mediated ADH1C expression by
directly binding to miR-135b-3p. The enforced LINC01339 or ADH1C markedly
hindered cell growth and migration in Wilms’ tumor. The LINC01339
overexpression also repressed the growth of Wilms’ tumors in vivo,
whereas miR-135b-3p overexpression exerted the opposite effects on
...
Source: Hormone and Metabolic Research - October 27, 2023 Category: Endocrinology Authors: Yu, Yang Liu, Yanfei Tags: Original Article: Endocrine Research Source Type: research
Long-COVID is Associated with Impaired Red Blood Cell
Function
In conclusion, our data suggest impaired
erythrocyte functionality in Long-COVID patients, leading to diminished oxygen
supply. This in turn could be an explanation for the CFS, dyspnea and anemia.
Further investigations are necessary to identify the underlying
pathomechanisms. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 27, 2023 Category: Endocrinology Authors: Kronstein-Wiedemann, Romy Tausche, Kristin Kolditz, Martin Teichert, Madeleine Thiel, Jessica Koschel, Dirk Tonn, Torsten K ünzel, Stephan R. Tags: Original Article: Endocrine Care Source Type: research
The Relationship Between Serum Fibroblast Growth Factor 23 and Klotho
Protein and Low Bone Mineral Density in Middle-Aged and Elderly Patients with
End-Stage Renal Disease
In conclusion, serum Klotho is closely related to BMD changes
in middle-aged and elderly patients with ESRD. A high Klotho level is a
protective factor and is expected to be a marker in reducing bone mineral
metabolism disorders and improving the prognosis of patients with ESRD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 24, 2023 Category: Endocrinology Authors: Huang, Ting He, Yicao Li, Ye Zhang, Haisong Wang, Qian Gao, Yan Tags: Original Article: Endocrine Care Source Type: research
β-Thalassemia and Diabetes Mellitus: Current State and Future
Directions
Horm Metab Res DOI: 10.1055/a-2185-5073β-Thalassemia major is a congenital hemoglobin disorder that requires
regular blood transfusion. The disease is often associated with iron overload
and diabetes mellitus, among other complications. Pancreatic iron overload in
β-thalassemia patients disrupts β-cell function and insulin
secretion and induces insulin resistance. Several risk factors, including family
history of diabetes, sedentary lifestyle, obesity, gender, and advanced age
increase the risk of diabetes in β-thalassemia patients. Precautionary
mea...
Source: Hormone and Metabolic Research - October 23, 2023 Category: Endocrinology Authors: Taneera, Jalal Mahgoub, Eglal Qannita, Reem Alalami, Ayah Shehadat, Ola Al Youssef, Mona Dib, Ayah Hajji, Alaa Al Hajji, Amani Al Al-Khaja, Fatheya Dewedar, Hany Hamad, Mawieh Tags: Review Source Type: research
Islet Like Cells Induced from Umbilical Cord Mesenchymal Stem Cells
with Neonatal Bovine Pancreatic Mesenchymal Exosomes for Treatment of Diabetes
Mellitus
Horm Metab Res DOI: 10.1055/a-2166-4546To investigate the safety and efficacy of the islet-like cell (cell) induced from
human umbilical cord mesenchymal stem cell (UCMSC) with different methods for
the treatment of diabetic animal model. UCMSCs were induced to βcells
with cytokines (CY) and neonatal bovine pancreatic mesenchymal cell exosomes
(Ex) combined with CY (EX+CY). The insulin secretion of UCMSC and
βcell was measured with ELISA when the cells were growing in different
concentrations of glucose media for different times. UCMSCs (4×105) and
th...
Source: Hormone and Metabolic Research - October 13, 2023 Category: Endocrinology Authors: Yun, Feiyu Zhaorigen, Bayalige Han, Xia Li, Xin Yun, Sheng Tags: Original Article: Endocrine Research Source Type: research
Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as
a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A
Pathway
Horm Metab Res DOI: 10.1055/a-2179-0283Circular RNAs (circRNAs) participate in the progression of human cancers and have
been broadly elucidated. Here, we aimed to elucidate the roles and functional
mechanisms of hsa_circ_0080608 (circ_0080608) in lung cancer. Quantitative
real-time PCR (qPCR) was performed to assess the mRNA expression levels of
circ_0080608, miR-661, and adrenoceptor alpha 1A (ADRA1A). Western blotting was
performed to measure ADRA1A protein levels. CCK-8, colony formation, and
Transwell assays were performed to determine the effect of circ_0080...
Source: Hormone and Metabolic Research - October 11, 2023 Category: Endocrinology Authors: Ren, Chengbo Cui, Ling Li, Ruibiao Song, Xiao Li, Jinqiu Xi, Qiang Zhang, Zhilin Zhao, Lixia Tags: Original Article: Endocrine Research Source Type: research
