Maternal Gestational Diabetes Mellitus and Congenital Heart Disease
in Offspring: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2238-1710Maternal diabetes has been related to an increased risk of congenital heart
disease (CHD) in offspring. However, inconsistent results were retrieved for
studies evaluating the association between gestational diabetes mellitus (GDM)
and CHD in offspring. We therefore performed a systematic review and
meta-analysis for comprehensive investigation. Observational studies were
identified by searching PubMed, Embase, and Web of Science according to the aim
of the meta-analysis. A randomized-effects model was used to pool the data b...
Source: Hormone and Metabolic Research - February 2, 2024 Category: Endocrinology Authors: Liu, Yun Yue, Lina Chang, Li Tags: Original Article: Endocrine Care Source Type: research
The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan
Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD
Mice
Horm Metab Res DOI: 10.1055/a-2236-8625For treatment of type 1 diabetes mellitus, a combination of immune-based
interventions and medication to promote beta-cell survival and proliferation has
been proposed. Dextromethorphan (DXM) is an N-methyl-D-aspartate receptor
antagonist with a good safety profile, and to date, preclinical and clinical
evidence for blood glucose-lowering and islet-cell-protective effects of DXM
have only been provided for animals and individuals with type 2 diabetes
mellitus. Here, we assessed the potential anti-diabetic effects of DXM in th...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: W örmeyer, Laura Nortmann, Oliver Hamacher, Anna Uhlemeyer, Celina Belgardt, Bengt Eberhard, Daniel Mayatepek, Ertan Meissner, Thomas Lammert, Eckhard Welters, Alena Tags: Original Article: Endocrine Research Source Type: research
Hsa_circ_0092355 Accelerates Papillary Thyroid Cancer Progression by
Regulating the miR-543/PDE5A Pathway
Horm Metab Res DOI: 10.1055/a-2233-0245CircRNAs have been found to participate in the progression of various tumors. In
the present study, we aimed to clarify the role of hsa_circ_0092355 in papillary
thyroid cancer (PTC) cell development. RT-qPCR was used to determine the
expression of hsa_circ_0092355, miR-543, and PDE5A. PTC cell proliferation was
ascertained via a cell colony formation assay and the CCK-8 test. Western
blotting was performed to examine the expression levels of PDE5A and
apoptosis-associated proteins (Bcl-2 and Bax) in PTC cells. A scratch woun...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: Sun, Zhijun Zhang, Min Ye, Yangmei Yang, Leilei Tags: Original Article: Endocrine Research Source Type: research
HINT2 may be One Clinical Significance Target for Patient with
Diabetes Mellitus and Reduced ROS-Induced Oxidative Stress and Ferroptosis by
MCU
Horm Metab Res DOI: 10.1055/a-2238-2689The World Health Organization (WHO) predicted that patients with diabetes around
the world will increase to 600 million by 2040, of which about 1/3 will
develop diabetic nephropathy (DN). Therefore, the present study aimed to uncover
therapeutic effect of HINT2 and determined its possible mechanisms. Patients
with diabetes mellitus and normal volunteers were enrolled at our hospital. Male
C57BL/6 mice were fed with a high fat diet and injected
intraperitoneally with STZ for once (100 mg/kg body weight).
Mouse podo...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: Bai, Mei Lu, Wei Tan, Jun Mei, Xin Tags: Original Article: Endocrine Research Source Type: research
Quality Evaluation of Metabolic-Associated Fatty Liver Disease
Guidelines and Expert Consensus
Horm Metab Res DOI: 10.1055/a-2224-1196The purpose of this study is to evaluate and analyze the quality of guidelines
and expert consensus on clinical practice regarding metabolically associated
fatty liver disease (MAFLD) over the past five years. Data from the websites
were retrieved using computers. We evaluated guidelines and expert consensus on
MAFLD that were officially published between January 1, 2018 and March 24, 2023.
Two evaluators independently examined the literature and extracted data. The
included literature on guidelines and expert consensus was t...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: Chen, Meijing Chen, Ying Liu, Dun Li, Ka Hu, Rong Chen, Jingyi Jiang, Xiaoying Lin, Jinqing Tags: Original Article: Endocrine Care Source Type: research
Thyroid Inflammation and Immunity During the COVID-19 Pandemic: A
Comprehensive Review and Case Study
Horm Metab Res 2024; 56: 111-117 DOI: 10.1055/a-2222-6300The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the development of
various vaccines. Reports have emerged suggesting a possible association between
SARS-CoV-2 vaccination and the onset of thyroid diseases. This review explores
the clinical aspects of thyroid disorders following SARS-CoV-2 vaccination,
including a case report of a patient with concomitant subacute thyroiditis (SAT)
and Graves’ disease (GD) with blocking thyro...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: Lampropoulou, Eleni Benz, Claus Kahaly, George J. F ührer, Dagmar Tags: Review Source Type: research
Meta-Analysis of the Efficacy and Safety Evaluation of Vandetanib in
the Treatment of Medullary Thyroid Cancer
Horm Metab Res DOI: 10.1055/a-2231-9192The aim of the work was to systematically evaluate the efficacy and safety of
Vandetanib in the treatment of advanced medullary thyroid carcinoma (MTC). MeSH
entries to search for randomized controlled trials and clinical research
literature on the application of Vandetanib in the treatment of medullary
thyroid cancer from PubMed, Chinese national knowledge infrastructure (CNKI),
and Web of Science databases since their establishment until March 2023 were
used. In terms of efficacy, the analysis results showed that Vandetanib...
Source: Hormone and Metabolic Research - January 26, 2024 Category: Endocrinology Authors: Xian, Tong-cheng Yang, Min-ye Zhang, Xue-lin Wang, Jie Luo, Yi Tags: Original Article: Endocrine Care Source Type: research
Association Between VEGF-460C/T Gene Polymorphism and Risk of
Diabetic Retinopathy in Type 2 Diabetes Mellitus: A
Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2223-2790The aim of the study was to investigate the relationship between
VEGF-460C/T polymorphism and susceptibility to diabetic retinopathy (DR)
in type 2 diabetes mellitus (T2DM) by meta-analysis. A comprehensive search was
conducted across six databases until September 2023 to identify studies
examining the association between VEGF-460C/T polymorphism and
susceptibility to DR. Data process was performed by Stata 15.0 software. Eight
studies were included, involving 1463 patients with DR. In the overall analysis,
the diff...
Source: Hormone and Metabolic Research - January 25, 2024 Category: Endocrinology Authors: Cheng, Bo Wu, Aimin Zhou, Xuewei Tags: Original Article: Endocrine Care Source Type: research
Renal Function Evolution and Hypoaldosteronism Risk After Unilateral
Adrenalectomy for Primary Aldosteronism
Horm Metab Res DOI: 10.1055/a-2221-3302Few studies demonstrated a percentage decrease in the estimated glomerular
filtration rate (eGFR) at a single time and the rate of hypoaldosteronism after
adrenalectomy for primary aldosteronism (PA). Our aim was to investigate the
evolution of renal function and the hypoaldosteronism risk after adrenalectomy
for PA. Aldosterone, renin, eGFR, and electrolyte levels were determined before
and at 1 week, 1, 3 and 6 months after unilateral adrenalectomy in 94 PA
patients (40 men and 54 women). The main outcome was the postoperat...
Source: Hormone and Metabolic Research - January 22, 2024 Category: Endocrinology Authors: Queiroz, Nara L. Stumpf, Matheo A. M. Souza, Victor C. M. Maciel, Ana Alice W. Fagundes, Gustavo F. C. Okubo, Jessica Srougi, Victor Tanno, Fabio Y. Chambo, Jose L. Pereira, Maria Adelaide A. Pio-Abreu, Andrea Bortolotto, Luiz A. Latronico, Ana Claudia Ba Tags: Original Article: Endocrine Care Source Type: research
Characteristics of Ovarian Cancer Immune Cell Invasion and
Bioinformatics to Predict the Effect of Immunotherapy
This study suggests that ICI
scores can be used as a feasible auxiliary indicator for predicting the
prognosis of patients with OC. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 19, 2024 Category: Endocrinology Authors: Yan, Lingli Fan, Erxi Tan, Bin Tags: Original Article: Endocrine Care Source Type: research
Anthropometric, Metabolic, and Endocrine Parameters as Predictors of
Estimated Average Glucose and Other Biomarkers of Dysglycemia in Women with
Different Phenotypes of Polycystic Ovary Syndrome
Horm Metab Res DOI: 10.1055/a-2207-0739The aim of the study was to evaluate the efficacy of anthropometric, metabolic,
and endocrine abnormalities as predictors of estimated average glucose and other
biomarkers of dysglycemia in women with different phenotypes of polycystic ovary
syndrome (PCOS). This cross-sectional study included 648 women with PCOS and 330
controls. A single protocol of investigation was applied for all subjects. PCOS
women were divided by phenotypes according to the Rotterdam criteria. Biomarkers
of dysglycemia were considered dependent variab...
Source: Hormone and Metabolic Research - January 10, 2024 Category: Endocrinology Authors: de Medeiros, Sebasti ão Freitas Winck Yamamoto de Medeiros, Ana Lin Souto de Medeiros, Matheus Ant ônio da Silva Carvalho, Anna Bethany Yamamoto, Marcia W. M. Soares, Jos é Baracat, Edmund C. Tags: Original Article: Endocrine Care Source Type: research
Correction: FAF1 Gene Involvement in Pituitary Corticotroph
Tumors
Horm Metab Res DOI: 10.1055/a-2229-4823 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - January 8, 2024 Category: Endocrinology Authors: Nguyen, Matthew Maria, Andrea Gutierrez Faucz, Fabio R. Trivellin, Giampaolo Stratakis, Constantine A. Tatsi, Christina Tags: Erratum Source Type: research
Risk Factors Analysis of Severe Liver Injury Induced by
Statins
Horm Metab Res DOI: 10.1055/a-2210-3395The aim of this study is to report the risk factors of severe statin induced
liver injury (SILI). From the database of Shandong ADR Monitoring Center and
Outpatients and inpatients in our hospital, SILI cases reported from 2013 to
2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion
and exclusion criteria of severe and general SILI were established separately.
After the SILI cases were selected and confirmed, the socio-demographic and
clinical characteristics were collected. Single factor chi-squar...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Su, Feng-yun Li, Wen-hua Zhao, Xu-dong Han, Qian Xu, Xin Geng, Tao Tags: Original Article: Endocrine Care Source Type: research
Current Evidence on Local Therapies in Advanced Adrenocortical
Carcinoma
Horm Metab Res 2024; 56: 91-98 DOI: 10.1055/a-2209-6022International guidelines emphasise the role of local therapies (LT) for the
treatment of advanced adrenocortical carcinoma (ACC). However, large studies are
lacking in this field. Therefore, we performed a review of the literature to
synthesise current evidence and develop clinical guidance. PubMed database was
searched for systematic literature. We identified 119 potentially relevant
articles, of which 21 could be included in our final analysis. All were
retrospective and reported on 374 patients treated with...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Kimpel, Otilia Dischinger, Ulrich Altieri, Barbara Fuss, Carmina Teresa Polat, B ülent Kickuth, Ralph Kroiss, Matthias Fassnacht, Martin Tags: Review Source Type: research
Endocrine Disruptors: Focus on the Adrenal Cortex
Horm Metab Res 2024; 56: 78-90 DOI: 10.1055/a-2198-9307Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere
with endocrine homeostasis and promote adverse health outcomes. Their impact on
the adrenal cortex, corticosteroids and their physiological role in the organism
has not yet been sufficiently elucidated. In this review, we collect
experimental and epidemiological evidence on adrenal disruption by relevant
endocrine disruptors. In vitro data suggest significant alterations of gene
expression, cell signalling, steroid production, st...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: P ötzl, Benedikt K ürzinger, Lydia Stopper, Helga Fassnacht, Martin Kurlbaum, Max Dischinger, Ulrich Tags: Review Source Type: research
