Current Evidence on Local Therapies in Advanced Adrenocortical Carcinoma
Horm Metab Res 2024; 56: 91-98 DOI: 10.1055/a-2209-6022International guidelines emphasise the role of local therapies (LT) for the
treatment of advanced adrenocortical carcinoma (ACC). However, large studies are
lacking in this field. Therefore, we performed a review of the literature to
synthesise current evidence and develop clinical guidance. PubMed database was
searched for systematic literature. We identified 119 potentially relevant
articles, of which 21 could be included in our final analysis. All were
retrospective and reported on 374 patients treated with LT for advanced ACC (12
studies on radiotherapy, 3 on transarterial chemoembolisation and
radioembolisation, 4 on image-guided thermal ablation [radiofrequency, microwave
ablation, and cryoablation, and two studies reporting treatment with several
different LT]). Radiotherapy was frequently performed with palliative intention.
However, in most patients, disease control and with higher dosage also partial
responses could be achieved. Data for other LT were more limited, but also point
towards local disease control in a significant percentage of patients. Very few
studies tried to identify factors that are predictive on response. Patients with
a disease-free interval after primary surgery of more than 9 months and
lesions<5 cm might benefit most. Underrepo...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Kimpel, Otilia Dischinger, Ulrich Altieri, Barbara Fuss, Carmina Teresa Polat, B ülent Kickuth, Ralph Kroiss, Matthias Fassnacht, Martin Tags: Review Source Type: research
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