Anti-M üllerian Hormone Accelerates Pathological Process of
Insulin Resistance in Polycystic Ovary Syndrome Patients
Horm Metab Res 2021; 53: 504-511 DOI: 10.1055/a-1499-7718Insulin resistance (IR) is one of the most common features of polycystic ovary
syndrome (PCOS), which is related to obesity. Whether increased
anti-Müllerian hormone (AMH) levels in PCOS are involved in the
pathogenesis of insulin resistance remains unclear. We investigated serum levels
of leptin and AMH along with basic clinical and metabolic parameters in 114 PCOS
patients and 181 non-PCOS women. PCOS patients presented higher fasting blood
glucose, insulin concentrations and Homeostatic Model Assessment ...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Li, Xiang-Juan Wang, Hui Lu, Dan-Yang Yu, Tian-Tian Ullah, Kamran Shi, Xin-Yan Shen, Yong-Hai Fei, Xiao-Yang Lin, Zhen-Yun Huang, He-Feng Lin, Xian-Hua Tags: Endocrine Care Source Type: research
Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk
Assessment of Patients with Rheumatic Diseases Treated with
Glucocorticoids
Horm Metab Res 2021; 53: 499-503 DOI: 10.1055/a-1528-7261Chronic glucocorticoid therapy is associated with osteoporosis and can cause
fractures in up to 50% of patients. Increased risk of fractures in
patients with glucocorticoid-induced osteoporosis does not result only from the
decreased bone mineral density (BMD) but also bone microarchitecture
deterioration. Trabecular bone score (TBS) is a method complementary to DXA,
providing additional information about trabecular bone structure. The aim of
this study was to assess the clinical utility of TBS in fracture r...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Nowakowska-P łaza, Anna Wro ński, Jakub Sudo ł-Szopińska, Iwona G łuszko, Piotr Tags: Endocrine Care Source Type: research
Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the
Disease
Horm Metab Res 2021; 53: 489-498 DOI: 10.1055/a-1546-1652Gestational diabetes mellitus (GDM), a type of pregnancy-specific glucose
intolerance or hyperglycemia, is one of the most common metabolic disorders in
pregnant women with 16.9% of the global prevalence of gestational
hyperglycemia. Not only are women with GDM likely to develop T2DM, but their
children are also at risk for birth complications or metabolic disease in
adulthood. Therefore, identifying the potential risk factors for GDM is very
important in the prevention and treatment of GDM. Previous studies...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Wei, Wenwen He, Yuejuan Wang, Xin Tan, Guiqin Zhou, Fangyu Zheng, Guangbing Tian, Dan Ma, Xiaomin Yu, Hongsong Tags: Review Source Type: research
A Case of Sporadic Pseudohypoparathyroidism Type 1B Presented with
Hypokalemia
Horm Metab Res DOI: 10.1055/a-1528-7471Luo et al. 1 reported two cases of autosomal
dominant pseudohypoparathyroidism type 1B (AD-PHP1B) and reviewed literature about
the genetic and epigenetic characteristics of AD-PHP1B. Pseudohypoparathyroidism
(PHP) is a cluster of heterogeneous diseases characterized by hypocalcemia and
hyperphosphatemia due to resistance to parathyroid hormone (PTH). PHP1B almost
results from methylation abnormalities of the maternal differentially methylated
regions (DMRs) and can be divided into sporadic PHP1B and AD-PHP1B 1. As mentioned ...
Source: Hormone and Metabolic Research - July 29, 2021 Category: Endocrinology Authors: Yang, Wen-jun Zhang, Qin Jin, Ping Tags: Letter to the Editor Source Type: research
Triglyceride-Glukose Index Predicts Adverse Events in Patients with
Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies
Horm Metab Res DOI: 10.1055/a-1518-7503The triglyceride-glucose (TyG) index, a recently proposed indicator for insulin
resistance, has been related with cardiovascular risks. We aimed to summarize
the association between TyG index and incidence of major adverse cardiovascular
events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies
demonstrating the association between TyG index and incidence of MACEs in ACS
patients with multivariate adjusted analyses were identified by search of
PubMed, Embase, and Web of Science databases. A random-effekt m...
Source: Hormone and Metabolic Research - July 23, 2021 Category: Endocrinology Authors: Li, Juying Ren, Ling Chang, Cheng Luo, Lin Tags: Endocrine Care Source Type: research
Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin
in Hypertensive Diabetic Patients with Nephropathy: A Randomized
Trial
Horm Metab Res 2021; 53: 470-477 DOI: 10.1055/a-1517-6643Angiogenesis is a multistep process implicated in the pathophysiology and
progression of diabetic nephropathy (DN). Angiotensin-converting enzyme
inhibitors (ACEI) and calcium channel blockers (CCB) have an important role in
DN. We performed a randomized-controlled trial of lisinopril alone (an ACEI) or
in combination with verapamil (a CCB) as a therapy for DN in type 2 diabetes
mellitus (T2DM) patients with hypertension (HTN) and urinary albumin creatinine
ratio (UACR) (30–300 mg/g) also to evaluate the...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Salem, Mohamed Sallam, Al-Aliaa M. Abdel-Aleem, Eman El-Mesallamy, Hala O. Tags: Endocrine Care Source Type: research
Prevalence of Primary Aldosteronism Across the Stages of Hypertension
Based on a New Combined Overnight Test
In conclusion, DCVT revealed that PA is a highly prevalent cause
of hypertension. DCVT could be employed as a diagnostic tool in all subjects
with arterial hypertension of unknown cause. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Voulgaris, Nick Tyfoxylou, Ernestini Vlachou, Sophia Kyriazi, Evagelia Gravvanis, Chris Kapsali, Chara Markou, Athina Papanastasiou, Labrini Gryparis, Alexandros Kassi, Eva Chrousos, George Kaltsas, Gregory Piaditis, George Tags: Endocrine Care Source Type: research
Age Moderates the Impact of TRAbs on Thyroid Hormones and Hepatic
Function in Patients with Graves ’ Disease
Horm Metab Res 2021; 53: 453-460 DOI: 10.1055/a-1510-9100Thyrotropin receptor antibodies (TRAbs) play a significant role in the course of
hepatic dysfunction (HDF) in patients with Graves’ disease (GD).
However, few studies have considered the factors that influence the
relationships among TRAbs, thyroid hormone levels, and hepatic function in
subjects with newly diagnosed GD. Here we investigated the associations of TRAbs
with thyroid hormones and hepatic function and assessed potential factors that
can influence these associations among patients with GD. A tot...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Guo, Kai Ling, Hongwei Zhou, Xiaoyan Ying, Changjiang Tags: Endocrine Care Source Type: research
Predicting the Course of Graves ’ Orbitopathy Using Serially
Measured TSH-Receptor Autoantibodies by Automated Binding Immunoassays and the
Functional Bioassay
Horm Metab Res 2021; 53: 435-443 DOI: 10.1055/a-1525-2070The aim of the study was to investigate the use of serial measurements of
TSH-receptor autoantibodies (TRAb) with the newest available assay technology to
predict the course of Graves’ Orbitopathy (GO) during the first 24
months from disease onset. Serial serum samples from patients with GO (103
mild/135 severe) were collected between 2007 and 2017 and
retrospectively analyzed. The course of GO were classified into
mild/severe 12 months after manifestation (severe: NOSPECS≥5;
mild<5). TRAb w...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: St öhr, Mareile Oeverhaus, Michael Lytton, Simon D. Horstmann, Mareike Zwanziger, Denise M öller, Lars Stark, Achim F ührer-Sakel, Dagmar Bechrakis, Nikolaos Berchner-Pfannschmidt, Utta Banga, J. Paul Philipp, Svenja Eckstein, Anja Tags: Endocrine Care Source Type: research
Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels
in Patients with Epilepsy: A Meta-Analysis
Horm Metab Res 2021; 53: 425-434 DOI: 10.1055/a-1517-6550We conducted this meta-analysis to assess the effects of sodium valproate (VPA)
monotherapy on blood liver enzymes in patients with epilepsy. PubMed, Web of
Science, EBSCO, Cochrane Library, Wanfang, China national knowledge
infrastructure databases were searched. Nine studies were included. Results
showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA
monotherapy group versus control group were 0.70 (95% CI=0.31 to
1.09, Z=3.52, p=0.0004), 0.47 (95%
CI=− 0.01 to 0.95, Z=1.91, p...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Fu, Jie Tao, Tao Li, Zuoxiao Chen, Yangmei Chen, Xiu Li, Jinglun Peng, Lilei Tags: Review Source Type: research
Treatment Strategies for Dopamine Agonist-Resistant and Aggressive
Prolactinomas: A Comprehensive Analysis of the Literature
Horm Metab Res 2021; 53: 413-424 DOI: 10.1055/a-1525-2131Despite most of the prolactinomas can be treated with endocrine therapy
and/or surgery, a significant percentage of these tumors can be
resistant to endocrine treatments and/or recur with prominent invasion
into the surrounding anatomical structures. Hence, clinical, pathological, and
molecular definitions of aggressive prolactinomas are important to guide for
classical and novel treatment modalities. In this review, we aimed to define
molecular endocrinological features of dopamine agonist-resistant and agg...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Sari, Ramazan Altinoz, Meric A. Ozlu, Eylem Burcu Kahraman Sav, Aydin Danyeli, Ayca Ersen Baskan, Ozdil Er, Ozlem Elmaci, Ilhan Tags: Review Source Type: research
miRNA-483 –5p Targets HDCA4 to Regulate Renal Tubular Damage
in Diabetic Nephropathy
Horm Metab Res DOI: 10.1055/a-1534-3166 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - July 16, 2021 Category: Endocrinology Authors: Liu, Lu Chen, Huanzhen Yun, Jie Song, Liqun Ma, Xiaopeng Luo, Shan Song, Yexu Tags: Erratum Source Type: research
The Relationship Between Intact Parathyroid Hormone and
25-Hydroxyvitamin D in United Kingdom Resident South Asians and Whites: A
Comparative, Cross-Sectional Observational Study
Horm Metab Res DOI: 10.1055/a-1521-5026Ethnic differences in intact parathyroid hormone (iPTH) at similar total 25
hydroxyvitamin D [25(OH)D] concentrations have been reported between US resident
Whites, Blacks, and Hispanics, but this has not been studied between South
Asians and Whites. We, therefore, compared the iPTH relationship to 25(OH)D in
UK resident South Asians and Whites. A comparative, cross-sectional
observational study in which demographic and laboratory data on South Asian and
White residents of Wolverhampton, UK were analyzed. Log-log models measu...
Source: Hormone and Metabolic Research - July 7, 2021 Category: Endocrinology Authors: Coley-Grant, Deon Jawad, Mohammed Ashby, Helen L. Cornes, Michael P. Kumar, Bharan Hallin, Magnus Nightingale, Peter G. Ford, Clare Gama, Rousseau Tags: Endocrine Care Source Type: research
Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained
Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic
Syndrome
Horm Metab Res DOI: 10.1055/a-1510-8896Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet
medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty
liver disease, obesity, weight loss and exercise resistance, heart disease,
stroke, depression, and brain health. Insulin resistance is purely nutrition
related, with a typical molecular disease food intake pattern. The insulin
resistant state is accessible by TyG as the appropriate surrogate marker, which
is found to lead the personalized molecular hepatic nutrition system...
Source: Hormone and Metabolic Research - June 30, 2021 Category: Endocrinology Authors: Rohner, Markus Heiz, Robert Feldhaus, Simon Bornstein, Stefan R. Tags: Endocrine Care Source Type: research
Value of [11C]-Methionine PET/CT in Preoperative Localization of Parathyroid Adenomas
In conclusion, MET-PET/CT seems a valuable imaging modality in primary hyperparathyroidism, at least as second line imaging approach, with a higher per-lesion sensitivity than ultrasound in such setting. Especially when ultrasound and/or subtraction scintigraphy are inconclusive or negative, MET-PET/CT directs the surgeon to the correct localization of the parathyroid adenoma. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - June 24, 2021 Category: Endocrinology Authors: Saerens, Julie Velkeniers, Brigitte Keyaerts, Marleen Raeymaeckers, Steven Vanhoeij, Marian Blotwijk, Susanne Bravenboer, Bert Tags: Endocrine Care Source Type: research
