BRAFV600E and BRAF-WT Specific Antitumor Immunity in
Papillary Thyroid Cancer
In conclusion, we
clearly demonstrated a BRAF-specific tumor immunity in PTC-patients which is,
however, independent of a BRAFV600E status of the PTC patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 25, 2022 Category: Endocrinology Authors: Ehlers, Margret Schmidt, Mathias Mattes-Gyorgy, Katalin Antke, Christina Enczmann, Juergen Schlensog, Martin Japp, Anna Haase, Matthias Allelein, Stephanie Dringenberg, Till Giesel, Frederik Esposito, Irene Schott, Matthias Tags: Original Article: Endocrine Research Source Type: research
Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant
in a Three-Generation Family with MODY7
Horm Metab Res DOI: 10.1055/a-1961-6281KLF11 regulates insulin gene expression through binding to the insulin promoter
and has been reported as a causative gene for maturity-onset diabetes of the
young 7 (MODY7). Here, we report a novel KLF11 variant associated with a
three-generation family with early childhood-onset diabetes and explore its
clinical and functional characteristics. The three-generational pedigree
contains five patients affected by diabetes. The pathogenic variant identified
by whole-exome sequencing was further confirmed by Sanger sequencing and
...
Source: Hormone and Metabolic Research - November 24, 2022 Category: Endocrinology Authors: Guan, Gaopeng Qin, Tiantian Zhao, Li-ling Jin, Ping Tags: Original Article: Endocrine Research Source Type: research
Androgens ’ Role in Severity and Mortality Rates of
COVID-19
Horm Metab Res DOI: 10.1055/a-1954-5605By the end of December 2019 new corona virus began to spread from Wuhan, China
and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex
discrepant patterns with higher rate of deaths and infection in males than
females which could be justified by androgen-mediated mechanisms. This review
aimed to assess the role of androgens in COVID-19 severity and mortality.
Androgens increase expressions of Type II transmembrane Serine Protease
(TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2), which both facilita...
Source: Hormone and Metabolic Research - November 21, 2022 Category: Endocrinology Authors: Ataei, Ali Derakhshan, Mohammad Moein Razmjooie, Mohadese Zare, Fateme Amiresmaeili, Habibe Salehi, Negin Namakkoobi, Negar Mirhosseini, Hamid Karim, Bardia Iravani, Sima Tags: Review Source Type: research
Circulating Growth Differentiation Factor 15 and Preeclampsia: A
Meta-Analysis
In conclusion, a higher circulating GDF-15 is observed
in women with preeclampsia even before the diagnosis of the disease. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 21, 2022 Category: Endocrinology Authors: Wang, Lihong Yang, Qiuli Tags: Original Article: Endocrine Care Source Type: research
Reduction of Severe Hypoglycemic Events Among Outpatients with Type 2
Diabetes Following Sodium-Glucose Cotransporter 2 Inhibitor Marketing in
Japan
In this study, we quantified the annual number of patients
with type 2 diabetes who experienced hypoglycemia needing the third-party
assistance who had random sample plasma
glucose<59.4 mg/dl (3.3 mmol/l) on the
one hand and analyzed the prescription trend of hypoglycemic agents all over
Japan on the other. Analysis of the annual number of hypoglycemic patients
visited ER was performed at Aizawa Hospital, a medical center located in the
midst of a city. The study duration was over 10 years from 2008 to 2019. We
found a clear-cut decreasi...
Source: Hormone and Metabolic Research - November 10, 2022 Category: Endocrinology Authors: Yamashita, Koh Yoshiike, Shouichi Yamashita, Taku Mori, Jun-ichirou Aizawa, Toru Tags: Original Article: Endocrine Care Source Type: research
Rhabdomyolysis Caused by Hypothyroidism: Research
Progress
Horm Metab Res 2022; 54: 731-735 DOI: 10.1055/a-1951-1646Rhabdomyolysis (RM) refers to the clinical syndrome caused by the release of
intracellular substances into the extracellular fluid and blood circulation
after rhabdomyocyte destruction due to various etiologies. In severe cases, RM
can lead to life-threatening conditions such as acute kidney injury.
Hypothyroidism is a rare cause of RM that can lead to missed diagnosis or
misdiagnosis, and the condition worsens in the absence of timely and effective
treatment. Herein, reported cases of RM caused by hypothyro...
Source: Hormone and Metabolic Research - November 10, 2022 Category: Endocrinology Authors: Zhou, Qingju Li, Bin Tian, Xin Tags: Review Source Type: research
Treatment of Primary Pigmented Nodular Adrenocortical
Disease
Horm Metab Res 2022; 54: 721-730 DOI: 10.1055/a-1948-6990Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of
adrenocorticotropin hormone (ACTH)-independent Cushing’s syndrome (CS),
which mainly occurs in children and young adults. Treatment options with proven
clinical efficacy for PPNAD include adrenalectomy (bilateral or unilateral
adrenalectomy) and drug treatment to control hypercortisolemia. Previously, the
main treatment of PPNAD is bilateral adrenal resection and long-term hormone
replacement after surgery. In recent years, cases r...
Source: Hormone and Metabolic Research - November 10, 2022 Category: Endocrinology Authors: Liu, Xinming Zhang, Siwen Guo, Yunran Gang, Xiaokun Wang, Guixia Tags: Review Source Type: research
Androgens role in severity and mortality rates of COVID-19
Discussion: androgens increase expression of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2) which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) was substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this...
Source: Hormone and Metabolic Research - November 4, 2022 Category: Endocrinology Authors: Ataei, Ali Derakhshan, Mohammad Moein razmjooie, mohadese zare, fateme Amiresmaeili, habibe salehi, negin namakkoobi, negar mirhosseini, hamid karim, bardia iravani, sima Tags: Review Source Type: research
Post COVID and Apheresis – Where are we
Standing?
Horm Metab Res DOI: 10.1055/a-1945-9694A continual increase in cases of Long/Post COVID constitutes a medical
and socioeconomic challenge to health systems around the globe. While the true
extent of this problem cannot yet be fully evaluated, recent data suggest that
up to 20% of people with confirmed SARS-CoV-2 suffer from clinically
relevant symptoms of Long/Post COVID several weeks to months after the
acute phase. The clinical presentation is highly variable with the main symptoms
being chronic fatigue, dyspnea, and cognitive symptoms. Extracorporeal apheresis
...
Source: Hormone and Metabolic Research - October 27, 2022 Category: Endocrinology Authors: Steenblock, Charlotte Walther, Romy Tselmin, Sergey Jarzebska, Natalia Voit-Bak, Karin Toepfner, Nicole Siepmann, Timo Passauer, Jens Hugo, Christian Wintermann, Gloria Julius, Ulrich Barbir, Mahmoud Khan, Tina Z. Puhan, Milo A. Straube, Richard Hohenstei Tags: Review Source Type: research
The Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C
Gene Polymorphism with Susceptibility to Diabetic Nephropathy: A
Meta-Analysis
In conclusion, MTHFR A1298C polymorphism is
associated with susceptibility to diabetic nephropathy. Allele C, genotype
CC+AC, and AC at MTHFR A1298C locus can increase the risk of diabetic
nephropathy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 20, 2022 Category: Endocrinology Authors: Huo, Yanhong Zhang, Wenbo Zhang, Xin Su, Li Li, Hao Wang, Fa Zhang, Yan Tags: Original Article: Endocrine Care Source Type: research
Metabolic Profile and Echocardiographic Evaluation in Adults with
Growth Hormone Deficiency
Horm Metab Res DOI: 10.1055/a-1941-8556Adult growth hormone deficiency (AGHD) is associated with increased
cardiovascular risks. The primary endpoint of this retrospective cohort study
was to compare metabolic profile and echocardiographic parameters in
childhood-onset (CO) and adulthood-onset (AO) AGHD patients. 26 patients with CO
AGHD (19 males, 26.8±8.5 years) and 41 patients with AO AGHD (23 males,
35.1±6.8 years) were included. The standard deviation score of
insulin-like growth factor-1 (IGF-1 SDS), metabolic profile, liver sonography
and echoca...
Source: Hormone and Metabolic Research - October 18, 2022 Category: Endocrinology Authors: Yang, Hongbo Xu, Hanyuan Wang, Linjie Duan, Lian Gong, Fengying Zhu, Huijuan Pan, Hui Tags: Original Article: Endocrine Care Source Type: research
Association of Metabolic Syndrome with Adverse Outcomes in Patients
with Stable Coronary Artery Disease: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1946-4823A consensus has not been reached on the association of metabolic syndrome (MetS)
with adverse outcomes in patients with stable coronary artery disease (CAD). The
purpose of this systematic review and meta-analysis was to summarize the
prognostic implication of MetS in patients with stable CAD. We comprehensively
searched articles indexing in PubMed and Embase databases until August 14, 2022.
Original studies investigating the association of MetS with adverse outcomes in
patients with stable CAD were included. Seven studies in...
Source: Hormone and Metabolic Research - October 14, 2022 Category: Endocrinology Authors: Su, Yongcai Zhang, Xiaole Tags: Original Article: Endocrine Care Source Type: research
Association Between the Variability of Glycated Hemoglobin and
Retinopathy in Patients with Type 2 Diabetes Mellitus: A
Meta-Analysis
In conclusion,
higher HbA1c variability may be associated with an increased risk of retinopathy
in patients with T2DM. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 12, 2022 Category: Endocrinology Authors: Zhai, Liping Lu, Jun Cao, Xinjian Zhang, Jun Yin, Yong Tian, Hu Tags: Original Article: Endocrine Care Source Type: research
Adipocyte-Derived Exosomal LINC00968 Promotes Mouse Retina
Microvascular Endothelial Cell Dysfunction in a High-Glucose Environment by
Modulating the miR-361 –5p/TRAF3 Axis
In conclusion, our results indicated
that in an H-glu environment, adipocyte exosomes damage microvascular
endothelial cells via a LINC00968/miR-361–5p/TRAF3
signaling pathway, which could possibly serve as a target for treating
diabetes-obesity-triggered microvascular complications. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - October 10, 2022 Category: Endocrinology Authors: He, Wenjing Lin, Anhua Wang, Chenxiu Tags: Original Article: Endocrine Research Source Type: research
Associations of PNPLA3 rs738409 Polymorphism with Plasma Lipid
Levels: A Systematic Review and Meta-Analysis
Horm Metab Res 2022; 54: 686-695 DOI: 10.1055/a-1929-1677Accumulating evidence has shown that the rs738409 polymorphism of patatin-like
phospholipase domain-containing 3 (PNPLA3) is associated with non-alcoholic
fatty liver disease (NAFLD). Since NAFLD has been reported to be associated with
lipid metabolism, this study is conducted to explore whether the rs738409
polymorphism of PNPLA3 was associated with lipid levels. By searching PubMed and
the Cochrane database from May 31, 2020, to June 30, 2021. Sixty-three studies
(81 003 subjects) were included for the ana...
Source: Hormone and Metabolic Research - October 7, 2022 Category: Endocrinology Authors: Luo, Zhi Liu, Yang Li, Hang Zhou, Yawen Peng, Yuanyuan Lin, Xuan Fang, Ying Wan, Jing Wei, Baozhu Tags: Original Article: Endocrine Care Source Type: research
