Androgens ’ Role in Severity and Mortality Rates of COVID-19
Horm Metab Res DOI: 10.1055/a-1954-5605By the end of December 2019 new corona virus began to spread from Wuhan, China
and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex
discrepant patterns with higher rate of deaths and infection in males than
females which could be justified by androgen-mediated mechanisms. This review
aimed to assess the role of androgens in COVID-19 severity and mortality.
Androgens increase expressions of Type II transmembrane Serine Protease
(TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2), which both facilitate new
corona virus entry into host cell and their expression is higher in young males
than females. According to observational studies, prevalence of COVID-19
infections and deaths was more in androgenic alopecic patients than patients
without androgenic alopecia. The COVID-19 mortality rates in aged men
(>60 years) were substantially higher than aged females and even young
males caused by high inflammatory activities such as cytokine storm due to
hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor
drugs considerably modified COVID-19 symptoms. Androgen deprivation therapy also
improved COVID-19 symptoms in prostate cancer: overall the role of androgens in
severity of COVID-19 and its associated mortality seemed to be very important...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Ataei, Ali Derakhshan, Mohammad Moein Razmjooie, Mohadese Zare, Fateme Amiresmaeili, Habibe Salehi, Negin Namakkoobi, Negar Mirhosseini, Hamid Karim, Bardia Iravani, Sima Tags: Review Source Type: research
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