Metabolic Profile and Echocardiographic Evaluation in Adults with Growth Hormone Deficiency
Horm Metab Res DOI: 10.1055/a-1941-8556Adult growth hormone deficiency (AGHD) is associated with increased
cardiovascular risks. The primary endpoint of this retrospective cohort study
was to compare metabolic profile and echocardiographic parameters in
childhood-onset (CO) and adulthood-onset (AO) AGHD patients. 26 patients with CO
AGHD (19 males, 26.8±8.5 years) and 41 patients with AO AGHD (23 males,
35.1±6.8 years) were included. The standard deviation score of
insulin-like growth factor-1 (IGF-1 SDS), metabolic profile, liver sonography
and echocardiographic parameters were compared. The IGF-1 SDS were significantly
lower in CO AGHD patients (p<0.05). AO AGHD patients showed much
profound glycolipid aberrations, elevated C-reactive protein levels
(p=0.012), and proportionally higher prevalence of non-alcoholic fatty
liver disease (95.2% vs.8.3%, p<0.001). In all subjects,
IGF-1 SDS was negatively related to low-density lipoprotein cholesterol, and
positively related to total cholesterol and lipoprotein a (Lpa). There were
significant differences between the two group with regard to the correlations
between IGF-1 SDS and high-density lipoprotein cholesterol, low-density
lipoprotein cholesterol, LPa, uric acid and creatinine (all p for
interaction<0.05). CO AGHD patients exhibited smaller heart,...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Yang, Hongbo Xu, Hanyuan Wang, Linjie Duan, Lian Gong, Fengying Zhu, Huijuan Pan, Hui Tags: Original Article: Endocrine Care Source Type: research