Homocysteine and the Mortality of Critically Ill Patients: A
Meta-Analysis
Horm Metab Res 2022; 54: 593-603 DOI: 10.1055/a-1897-5992Prevalence of hyperhomocysteinemia (HHcy) is high in critically ill patients.
However, the association between serum homocysteine level and outcomes of the
critically ill patients remains unknown. We performed a meta-analysis of cohort
studies to comprehensively evaluate the above association. Relevant cohort
studies were identified by search of electronic databases including PubMed,
Embase, Web of Science, Wanfang, and CNKI from the inception of the databases to
February 5, 2022. A randomized-effect model i...
Source: Hormone and Metabolic Research - September 7, 2022 Category: Endocrinology Authors: Yuan, Fawei Zheng, Kun Tags: Original Article: Endocrine Care Source Type: research
The Potential of Electrical Stimulation and Smart Textiles for
Patients with Diabetes Mellitus
Horm Metab Res 2022; 54: 583-586 DOI: 10.1055/a-1892-6489Diabetes mellitus is one of the most frequent diseases in the general population.
Electrical stimulation is a treatment modality based on the transmission of
electrical pulses into the body that has been widely used for improving wound
healing and for managing acute and chronic pain. Here, we discuss recent
advancements in electroceuticals and haptic/smart devices for quality of
life and present in which patients and how electrical stimulation may prove to
be useful for the treatment of diabetes-related comp...
Source: Hormone and Metabolic Research - September 7, 2022 Category: Endocrinology Authors: Engler, Babette Tselmin, Sergey Ziehl, Doreen Weigmann, Ingo Birkenfeld, Andreas Bornstein, Stefan R. Barthel, Andreas Drechsel, Tina Zippenfennig, Claudio Milani, Thomas Perakakis, Nikolaos Tags: Review Source Type: research
Immune Checkpoint Inhibitor Therapy in Neuroendocrine Tumors
Horm Metab Res DOI: 10.1055/a-1908-7790Neuroendocrine tumors (NETs) occur in various regions of the body and present with complex clinical and biochemical phenotypes. The molecular underpinnings that give rise to such varied manifestations have not been completely deciphered. The management of neuroendocrine tumors (NETs) involves surgery, locoregional therapy, and/or systemic therapy. Several forms of systemic therapy, including platinum-based chemotherapy, temozolomide/capecitabine, tyrosine kinase inhibitors, mTOR inhibitors, and peptide receptor radionuclide therapy have been extensively studied and implemented in the ...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Gubbi, Sriram Vijayvergia, Namrata Yu, Jian Q KLUBO-GWIEZDZINSKA, JOANNA Koch, Christian Tags: Review Source Type: research
Immune Checkpoint Inhibitor Therapy in Neuroendocrine
Tumors
Horm Metab Res DOI: 10.1055/a-1908-7790Neuroendocrine tumors (NETs) occur in various regions of the body and present
with complex clinical and biochemical phenotypes. The molecular underpinnings
that give rise to such varied manifestations have not been completely
deciphered. The management of neuroendocrine tumors (NETs) involves surgery,
locoregional therapy, and/or systemic therapy. Several forms of systemic
therapy, including platinum-based chemotherapy,
temozolomide/capecitabine, tyrosine kinase inhibitors, mTOR inhibitors,
and peptide receptor radi...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Gubbi, Sriram Vijayvergia, Namrata Yu, Jian Q Klubo-Gwiezdzinska, Joanna Koch, Christian A. Tags: Review Source Type: research
Steroid Receptor Coactivator-Interacting Protein (SIP) Alleviates
Ischemic Cerebral Infarction Damage Through the NF- κB
Pathway
This study examined the rule of SIP
treatment to support neuron protective effect after cerebral injury in an animal
model of middle cerebral artery occlusion (MCAO). After
ischemia/reperfusion, neurological function, neuroglia cells activation,
infarction volume, brain water content, brain tissue apoptosis ratio, and
inflammatory response were assessed, and quantitative PCR and western blot were
also detected, respectively. Treatment of SIP ameliorated neurological
dysfunction, brain infarction, brain edema, and brain cell apoptosis after MCAO
...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Yu, Min Li, Yan Tan, Xianpei Hu, Qiao Tags: Original Article: Endocrine Research Source Type: research
LINC02875 Upregulation Contributed to Poor Prognosis for the
Hepatocellular Carcinoma and Progression for the Cancerous Cells
Horm Metab Res DOI: 10.1055/a-1913-8223The prognostic implications and physiological effect of LINC02875 are unknown in
hepatocellular carcinoma (HCC). We sought to examine the prognostic value of
LINC02875 in HCC and assessed its role in HCC cellular function. LINC02875
expression was evaluated by RT-qPCR in HCC specimens and cell lines. LINC02875
expression was subjected to assess the correlation with clinical parameters by
Chi-squared test and overall survival by Kaplan – Meier curve and Cox
regression analysis. The effects of LINC02875 on the biological char...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Liu, Yujian Yang, Jingrui Ke, Rui-Sheng Wu, Lupeng Hong, Zaifa Guo, Ping Feng, Liuxing Li, Zhimin Tags: Original Article: Endocrine Research Source Type: research
Can Serum Thyroglobulin Levels Help to Identify the Involved Neck
Compartment of Differentiated Thyroid Carcinoma?
Horm Metab Res DOI: 10.1055/a-1903-1800We aimed to evaluate the predictive ability of serum thyroglobulin (Tg) levels on
the localization of the metastatic lymph node compartments in locoregional
metastases of papillary thyroid cancer (PTC). This retrospective study included
143 patients who underwent neck dissections for a total of 172 for
persistent/recurrent locoregional PTC. They were grouped according to
the localization of lymph node metastasis (LNM): Central (C-LNM), Lateral
(L-LNM), both central and lateral LNM (C+L LNM). To confirm that the Tg
c...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Bah çecioğlu, Adile Begüm Ozkan, Elgin Araz, Mine Elhan, Atilla Halil Erdo ğan, Murat Faik Tags: Original Article: Endocrine Care Source Type: research
Correction: COVID-19 and Therapeutic Apheresis
Horm Metab Res 2022; 54: e5-e5 DOI: 10.1055/a-1930-9384 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Tselmin, Sergey Julius, Ulrich Jarzebska, Natalia Rodionov, Roman N. Tags: Erratum Source Type: research
Novel Therapeutic Agents for Rare Diseases of Calcium and Phosphate
Metabolism
Horm Metab Res DOI: 10.1055/a-1917-0519The last decade has been revolutionary regarding the management of rare bone
diseases caused by impaired calcium and phosphate metabolism. Elucidation of the
underlying genetic basis and pathophysiologic alterations has been the
determinant factor for the development of new, disease-specific treatment
agents. The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) possesses a
critical role in the pathogenesis of various hypophosphatemic disorders. Among
them, the genetic disorder of X-linked hypophosphatemia and the acqu...
Source: Hormone and Metabolic Research - September 1, 2022 Category: Endocrinology Authors: Roumpou, Afroditi Yavropoulou, Maria P Chronopoulos, Efstathios Kassi, Eva Tags: Review Source Type: research
Influence of Sodium-Glucose Cotransporter-2 Inhibitors on Plasma
Adiponectin in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized
Controlled Trials
In conclusion, SGLT-2 inhibitors could significantly
increase plasma adiponectin as compared with placebo in T2DM patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 1, 2022 Category: Endocrinology Authors: Wang, Yang Xia, Ning Tags: Original Article: Endocrine Care Source Type: research
Serum Calcium, Magnesium, and Phosphorus Levels in Patients with
COVID-19: Relationships with Poor Outcome and Mortality
In conclusion, CorrCa can be used as a simple and reliable marker of poor
outcome in patients with COVID-19, although not to predict the risk of
in-hospital mortality. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 23, 2022 Category: Endocrinology Authors: D íez, Juan J. Iglesias, Pedro Garc ía, Agustín Mart ín-Casasempere, Ignacio Bernab éu-Andréu, Francisco A. Tags: Original Article: Endocrine Care Source Type: research
MiR-30a-3p Targeting FLT1 Modulates Trophoblast Cell Proliferation in
the Pathogenesis of Preeclampsia
In conclusion, persistent high levels of FLT1 and miR-30a-3p may pose adverse
effects on angiogenesis and trophoblast proliferation in placenta of PE
patients. Therefore, targeting FLT1 and miR-30a-3p may serve as ideal strategies
for managing patients with PE. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 18, 2022 Category: Endocrinology Authors: Wang, Yuping Wang, Lanlan Yu, Xiaoyan Gong, Wenwen Tags: Original Article: Endocrine Research Source Type: research
LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting
the miR-142-3p
Horm Metab Res DOI: 10.1055/a-1891-6864Prostate cancer is a common male cancer with high morbidity and mortality
worldwide. According to current research, the integration of long non-coding RNA
(lncRNAs) and microRNA(miRNAs) can be expressed in a variety of cancers and play
an important role in diagnosis. Based on this, this study explored the clinical
role of lncRNA MAGI2-AS3 (MAGI2-AS3) in prostate cancer. By detecting the
expression levels of MAGI2-AS3 and miR-142-3p, the correlation between the
MAGI2-AS3 expression and the characteristics of clinical data was ...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Hu, Renbao Wu, Pei Liu, Jianhui Tags: Original Article: Endocrine Research Source Type: research
COVID-19 and Therapeutic Apheresis
We describe here the rationale and the initial
attempts of TA treatment in severe cases of acute COVID-19. We next review the
evidence for the role of autoimmunity, microcirculatory changes and inflammation
in pathogenesis of Long/Post COVID and the rationale for targeting those
pathogenic processes by different methods of TA. Finally, we discuss the impact
of COVID-19 pandemic on patients, who undergo regular TA treatments due to their
underlying chronic conditions, with the specific focus on the patients with
inherited lipid diseases being treated at t...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Tselmin, Sergey Julius, Ulrich Jarzebska, Natalia Rodionov, RomanN. Tags: Review Source Type: research
Treating Insulin Resistance with Intermittent Personalized Nutrition
to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of
Viral Diseases Especially COVID-19 and Long-COVID
Horm Metab Res 2022; 54: 567-570 DOI: 10.1055/a-1864-8234The Covid-19 pandemic has provided new and strong evidence for poor outcomes of
viral infection in patients with poor metabolic health. Insulin resistance is at
the root of many metabolic conditions and a key driver of their progression as
it promotes ineffectual inflammation whilst impairing immune functions. In a
vicious circle, insulin resistance facilitates SARS-CoV-2 infection, whilst
infection drives insulin resistance. We discuss the underlying mechanisms and
explore ways to improve metabolic health a...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Rohner, Markus Schwarz, Peter E. H. Bornstein, Stefan R. Tags: Review Source Type: research