Homocysteine and the Mortality of Critically Ill Patients: A Meta-Analysis
Horm Metab Res 2022; 54: 593-603 DOI: 10.1055/a-1897-5992Prevalence of hyperhomocysteinemia (HHcy) is high in critically ill patients. However, the association between serum homocysteine level and outcomes of the critically ill patients remains unknown. We performed a meta-analysis of cohort studies to comprehensively evaluate the above association. Relevant cohort studies were identified by search of electronic databases including PubMed, Embase, Web of Science, Wanfang, and CNKI from the inception of the databases to February 5, 2022. A randomized-effect model i...
Source: Hormone and Metabolic Research - September 7, 2022 Category: Endocrinology Authors: Yuan, Fawei Zheng, Kun Tags: Original Article: Endocrine Care Source Type: research

The Potential of Electrical Stimulation and Smart Textiles for Patients with Diabetes Mellitus
Horm Metab Res 2022; 54: 583-586 DOI: 10.1055/a-1892-6489Diabetes mellitus is one of the most frequent diseases in the general population. Electrical stimulation is a treatment modality based on the transmission of electrical pulses into the body that has been widely used for improving wound healing and for managing acute and chronic pain. Here, we discuss recent advancements in electroceuticals and haptic/smart devices for quality of life and present in which patients and how electrical stimulation may prove to be useful for the treatment of diabetes-related comp...
Source: Hormone and Metabolic Research - September 7, 2022 Category: Endocrinology Authors: Engler, Babette Tselmin, Sergey Ziehl, Doreen Weigmann, Ingo Birkenfeld, Andreas Bornstein, Stefan R. Barthel, Andreas Drechsel, Tina Zippenfennig, Claudio Milani, Thomas Perakakis, Nikolaos Tags: Review Source Type: research

Immune Checkpoint Inhibitor Therapy in Neuroendocrine Tumors
Horm Metab Res DOI: 10.1055/a-1908-7790Neuroendocrine tumors (NETs) occur in various regions of the body and present with complex clinical and biochemical phenotypes. The molecular underpinnings that give rise to such varied manifestations have not been completely deciphered. The management of neuroendocrine tumors (NETs) involves surgery, locoregional therapy, and/or systemic therapy. Several forms of systemic therapy, including platinum-based chemotherapy, temozolomide/capecitabine, tyrosine kinase inhibitors, mTOR inhibitors, and peptide receptor radionuclide therapy have been extensively studied and implemented in the ...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Gubbi, Sriram Vijayvergia, Namrata Yu, Jian Q KLUBO-GWIEZDZINSKA, JOANNA Koch, Christian Tags: Review Source Type: research

Immune Checkpoint Inhibitor Therapy in Neuroendocrine Tumors
Horm Metab Res DOI: 10.1055/a-1908-7790Neuroendocrine tumors (NETs) occur in various regions of the body and present with complex clinical and biochemical phenotypes. The molecular underpinnings that give rise to such varied manifestations have not been completely deciphered. The management of neuroendocrine tumors (NETs) involves surgery, locoregional therapy, and/or systemic therapy. Several forms of systemic therapy, including platinum-based chemotherapy, temozolomide/capecitabine, tyrosine kinase inhibitors, mTOR inhibitors, and peptide receptor radi...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Gubbi, Sriram Vijayvergia, Namrata Yu, Jian Q Klubo-Gwiezdzinska, Joanna Koch, Christian A. Tags: Review Source Type: research

Steroid Receptor Coactivator-Interacting Protein (SIP) Alleviates Ischemic Cerebral Infarction Damage Through the NF- κB Pathway
This study examined the rule of SIP treatment to support neuron protective effect after cerebral injury in an animal model of middle cerebral artery occlusion (MCAO). After ischemia/reperfusion, neurological function, neuroglia cells activation, infarction volume, brain water content, brain tissue apoptosis ratio, and inflammatory response were assessed, and quantitative PCR and western blot were also detected, respectively. Treatment of SIP ameliorated neurological dysfunction, brain infarction, brain edema, and brain cell apoptosis after MCAO ...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Yu, Min Li, Yan Tan, Xianpei Hu, Qiao Tags: Original Article: Endocrine Research Source Type: research

LINC02875 Upregulation Contributed to Poor Prognosis for the Hepatocellular Carcinoma and Progression for the Cancerous Cells
Horm Metab Res DOI: 10.1055/a-1913-8223The prognostic implications and physiological effect of LINC02875 are unknown in hepatocellular carcinoma (HCC). We sought to examine the prognostic value of LINC02875 in HCC and assessed its role in HCC cellular function. LINC02875 expression was evaluated by RT-qPCR in HCC specimens and cell lines. LINC02875 expression was subjected to assess the correlation with clinical parameters by Chi-squared test and overall survival by Kaplan – Meier curve and Cox regression analysis. The effects of LINC02875 on the biological char...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Liu, Yujian Yang, Jingrui Ke, Rui-Sheng Wu, Lupeng Hong, Zaifa Guo, Ping Feng, Liuxing Li, Zhimin Tags: Original Article: Endocrine Research Source Type: research

Can Serum Thyroglobulin Levels Help to Identify the Involved Neck Compartment of Differentiated Thyroid Carcinoma?
Horm Metab Res DOI: 10.1055/a-1903-1800We aimed to evaluate the predictive ability of serum thyroglobulin (Tg) levels on the localization of the metastatic lymph node compartments in locoregional metastases of papillary thyroid cancer (PTC). This retrospective study included 143 patients who underwent neck dissections for a total of 172 for persistent/recurrent locoregional PTC. They were grouped according to the localization of lymph node metastasis (LNM): Central (C-LNM), Lateral (L-LNM), both central and lateral LNM (C+L LNM). To confirm that the Tg c...
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Bah çecioğlu, Adile Begüm Ozkan, Elgin Araz, Mine Elhan, Atilla Halil Erdo ğan, Murat Faik Tags: Original Article: Endocrine Care Source Type: research

Correction: COVID-19 and Therapeutic Apheresis
Horm Metab Res 2022; 54: e5-e5 DOI: 10.1055/a-1930-9384 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 2, 2022 Category: Endocrinology Authors: Tselmin, Sergey Julius, Ulrich Jarzebska, Natalia Rodionov, Roman N. Tags: Erratum Source Type: research

Novel Therapeutic Agents for Rare Diseases of Calcium and Phosphate Metabolism
Horm Metab Res DOI: 10.1055/a-1917-0519The last decade has been revolutionary regarding the management of rare bone diseases caused by impaired calcium and phosphate metabolism. Elucidation of the underlying genetic basis and pathophysiologic alterations has been the determinant factor for the development of new, disease-specific treatment agents. The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) possesses a critical role in the pathogenesis of various hypophosphatemic disorders. Among them, the genetic disorder of X-linked hypophosphatemia and the acqu...
Source: Hormone and Metabolic Research - September 1, 2022 Category: Endocrinology Authors: Roumpou, Afroditi Yavropoulou, Maria P Chronopoulos, Efstathios Kassi, Eva Tags: Review Source Type: research

Influence of Sodium-Glucose Cotransporter-2 Inhibitors on Plasma Adiponectin in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
In conclusion, SGLT-2 inhibitors could significantly increase plasma adiponectin as compared with placebo in T2DM patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - September 1, 2022 Category: Endocrinology Authors: Wang, Yang Xia, Ning Tags: Original Article: Endocrine Care Source Type: research

Serum Calcium, Magnesium, and Phosphorus Levels in Patients with COVID-19: Relationships with Poor Outcome and Mortality
In conclusion, CorrCa can be used as a simple and reliable marker of poor outcome in patients with COVID-19, although not to predict the risk of in-hospital mortality. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 23, 2022 Category: Endocrinology Authors: D íez, Juan J. Iglesias, Pedro Garc ía, Agustín Mart ín-Casasempere, Ignacio Bernab éu-Andréu, Francisco A. Tags: Original Article: Endocrine Care Source Type: research

MiR-30a-3p Targeting FLT1 Modulates Trophoblast Cell Proliferation in the Pathogenesis of Preeclampsia
In conclusion, persistent high levels of FLT1 and miR-30a-3p may pose adverse effects on angiogenesis and trophoblast proliferation in placenta of PE patients. Therefore, targeting FLT1 and miR-30a-3p may serve as ideal strategies for managing patients with PE. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 18, 2022 Category: Endocrinology Authors: Wang, Yuping Wang, Lanlan Yu, Xiaoyan Gong, Wenwen Tags: Original Article: Endocrine Research Source Type: research

LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting the miR-142-3p
Horm Metab Res DOI: 10.1055/a-1891-6864Prostate cancer is a common male cancer with high morbidity and mortality worldwide. According to current research, the integration of long non-coding RNA (lncRNAs) and microRNA(miRNAs) can be expressed in a variety of cancers and play an important role in diagnosis. Based on this, this study explored the clinical role of lncRNA MAGI2-AS3 (MAGI2-AS3) in prostate cancer. By detecting the expression levels of MAGI2-AS3 and miR-142-3p, the correlation between the MAGI2-AS3 expression and the characteristics of clinical data was ...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Hu, Renbao Wu, Pei Liu, Jianhui Tags: Original Article: Endocrine Research Source Type: research

COVID-19 and Therapeutic Apheresis
We describe here the rationale and the initial attempts of TA treatment in severe cases of acute COVID-19. We next review the evidence for the role of autoimmunity, microcirculatory changes and inflammation in pathogenesis of Long/Post COVID and the rationale for targeting those pathogenic processes by different methods of TA. Finally, we discuss the impact of COVID-19 pandemic on patients, who undergo regular TA treatments due to their underlying chronic conditions, with the specific focus on the patients with inherited lipid diseases being treated at t...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Tselmin, Sergey Julius, Ulrich Jarzebska, Natalia Rodionov, RomanN. Tags: Review Source Type: research

Treating Insulin Resistance with Intermittent Personalized Nutrition to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of Viral Diseases Especially COVID-19 and Long-COVID
Horm Metab Res 2022; 54: 567-570 DOI: 10.1055/a-1864-8234The Covid-19 pandemic has provided new and strong evidence for poor outcomes of viral infection in patients with poor metabolic health. Insulin resistance is at the root of many metabolic conditions and a key driver of their progression as it promotes ineffectual inflammation whilst impairing immune functions. In a vicious circle, insulin resistance facilitates SARS-CoV-2 infection, whilst infection drives insulin resistance. We discuss the underlying mechanisms and explore ways to improve metabolic health a...
Source: Hormone and Metabolic Research - August 9, 2022 Category: Endocrinology Authors: Rohner, Markus Schwarz, Peter E. H. Bornstein, Stefan R. Tags: Review Source Type: research