Serum 25(OH)D Concentration and Cardiovascular Disease Risk Markers
Among Middle-Aged Healthy and Type 2 Diabetic Subjects
Horm Metab Res DOI: 10.1055/a-1534-2747Vitamin D deficiency is a major widespread health concern and is linked to a high
risk of cardiovascular disease (CVD). Thus, we have investigated the association
of vitamin D with various CVD risk markers. The present study comprises 90
control and 90 type 2 diabetes mellitus (T2DM) subjects of both sexes (age
range, 30–50 years). The 25 hydroxyvitamin D [25(OH)D] and CVD risk
markers including high sensitive C-reactive protein (hs-CRP), monocyte
chemoattractant protein-1 (MCP-1), intact parathyroid hormone (I-PTH),
...
Source: Hormone and Metabolic Research - August 25, 2021 Category: Endocrinology Authors: Dhas, Yogita Banerjee, Joyita Damle, Gauri Mishra, Neetu Tags: Endocrine Care Source Type: research
Importance of Setting Up Reference Intervals and Multiple of Medians
(MoM)
Horm Metab Res DOI: 10.1055/a-1432-2225I was interested in the article of Kianpour et al. on reference intervals for thyroid
hormones during the first trimester of gestation from an area with sufficient iodine
level 1. The unavailability of data in this
population had triggered this study where 436 pregnant and 444 non-pregnant women
were recruited. I appreciate the great effort taken by the authors to recruit such a
large population for the study. Following screening as per exclusion criteria 291
pregnant women were eliminated and thus the data of 145 pregnant wa...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Nanda, Rachita Tags: Letter to the Editor Source Type: research
Reference Intervals for Thyroid Hormones During the First Trimester
of Gestation: A Report from an Area with a Sufficient Iodine
Level
Horm Metab Res DOI: 10.1055/a-1430-3456 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Kianpour, Maryam Aminorroaya, Ashraf Amini, Massoud Feizi, Awat Janghorbani, Mohsen Shokri, Saeideh Yamini, Sima Aminorroaya Farghadani, Maryam Hekmatnia, Ali Gharib, Hossien Tags: Letter to the Editor Source Type: research
Correction: Reference Intervals for Thyroid Hormones During the First Trimester
of Gestation: A Report from an Area with a Sufficient Iodine
Level
Horm Metab Res DOI: 10.1055/a-1522-4612 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Kianpour, Maryam Aminorroaya, Ashraf Amini, Massoud Feizi, Awat Janghorbani, Mohsen Shokri, Saeideh Yamini, Sima Aminorroaya Farghadani, Maryam Hekmatnia, Ali Gharib, Hossien Tags: Erratum Source Type: research
Associations of the Polymorphisms in ADIPOQ with Circulating
Levels of Adiponectin and Lipids: A Meta-Analysis
Horm Metab Res 2021; 53: 541-561 DOI: 10.1055/a-1543-6362The relationships between the rs266729, rs1501299, and rs2241766 polymorphisms in
adiponectin gene (ADIPOQ) and circulating levels of adiponectin and
lipids remain to be clarified. Databases including PubMed and Embase were
searched for eligible studies. The random-effects model was used, and
standardized mean difference (SMD) with 95% confidence interval (CI) was
calculated to estimate the differences in circulating levels of adiponectin and
lipids between the subjects with different genotypes. A total of 1...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Su, Mi Jia, Aimei He, Yilan Song, Yongyan Tags: Endocrine Care Source Type: research
Impact of Clomiphene Citrate on the Steroid Profile in Dysmetabolic
Men with Low Testosterone Levels
Horm Metab Res 2021; 53: 520-528 DOI: 10.1055/a-1542-8763Clomiphene citrate (CC) in male hypogonadism increases testosterone (T) and
estrogen levels by stimulating pituitary gonadotropin release. Our group
confirmed these hormonal changes in a randomized, cross-over, double-blind trial
of CC versus placebo in addition to metformin, conducted in 21 obese
dysmetabolic men with low T levels. However, we hypothesize that based on its
mechanism of action, CC may directly or indirectly affect adrenal
steroidogenesis. The aim of this sub-study was to better understand th...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Pelusi, Carla Fanelli, Flamina Baccini, Margherita De Pergola, Giovanni Triggiani, Vincenzo Mezzullo, Marco Fazzini, Alessia Di Dalmazi, Guido Petrovic, Biljana Paterini, Paola Labate, Antonio Maria Morselli Pagotto, Uberto Giagulli, Vito Angelo Tags: Endocrine Care Source Type: research
DHEAS and Differential Blood Counts as Indirect Signs of
Glucocorticoid Excess in Adrenal Non-Producing Adenomas
Horm Metab Res 2021; 53: 512-519 DOI: 10.1055/a-1539-6442The majority of incidentally discovered adrenal tumors are later characterized as
non-producing adrenocortical adenomas (NPA). We asked whether laboratory
abnormalities in parameters that reflect glucocorticoid action can be found in
patients with NPA despite their nature of being clinically unapparent. Since
glucocorticoids are potent immunosuppressants we studied blood counts and
differential blood counts along with corticotropin and dehydroepiandrostenedione
sulfate (DHEAS) blood concentrations, as well a...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Winzinger, Eliza P. Jandikova, Hana Haase, Matthias Knauerhase, Andreas Winzinger, Tudor Schott, Matthias Willenberg, Holger S. Tags: Endocrine Care Source Type: research
Anti-M üllerian Hormone Accelerates Pathological Process of
Insulin Resistance in Polycystic Ovary Syndrome Patients
Horm Metab Res 2021; 53: 504-511 DOI: 10.1055/a-1499-7718Insulin resistance (IR) is one of the most common features of polycystic ovary
syndrome (PCOS), which is related to obesity. Whether increased
anti-Müllerian hormone (AMH) levels in PCOS are involved in the
pathogenesis of insulin resistance remains unclear. We investigated serum levels
of leptin and AMH along with basic clinical and metabolic parameters in 114 PCOS
patients and 181 non-PCOS women. PCOS patients presented higher fasting blood
glucose, insulin concentrations and Homeostatic Model Assessment ...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Li, Xiang-Juan Wang, Hui Lu, Dan-Yang Yu, Tian-Tian Ullah, Kamran Shi, Xin-Yan Shen, Yong-Hai Fei, Xiao-Yang Lin, Zhen-Yun Huang, He-Feng Lin, Xian-Hua Tags: Endocrine Care Source Type: research
Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk
Assessment of Patients with Rheumatic Diseases Treated with
Glucocorticoids
Horm Metab Res 2021; 53: 499-503 DOI: 10.1055/a-1528-7261Chronic glucocorticoid therapy is associated with osteoporosis and can cause
fractures in up to 50% of patients. Increased risk of fractures in
patients with glucocorticoid-induced osteoporosis does not result only from the
decreased bone mineral density (BMD) but also bone microarchitecture
deterioration. Trabecular bone score (TBS) is a method complementary to DXA,
providing additional information about trabecular bone structure. The aim of
this study was to assess the clinical utility of TBS in fracture r...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Nowakowska-P łaza, Anna Wro ński, Jakub Sudo ł-Szopińska, Iwona G łuszko, Piotr Tags: Endocrine Care Source Type: research
Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the
Disease
Horm Metab Res 2021; 53: 489-498 DOI: 10.1055/a-1546-1652Gestational diabetes mellitus (GDM), a type of pregnancy-specific glucose
intolerance or hyperglycemia, is one of the most common metabolic disorders in
pregnant women with 16.9% of the global prevalence of gestational
hyperglycemia. Not only are women with GDM likely to develop T2DM, but their
children are also at risk for birth complications or metabolic disease in
adulthood. Therefore, identifying the potential risk factors for GDM is very
important in the prevention and treatment of GDM. Previous studies...
Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Wei, Wenwen He, Yuejuan Wang, Xin Tan, Guiqin Zhou, Fangyu Zheng, Guangbing Tian, Dan Ma, Xiaomin Yu, Hongsong Tags: Review Source Type: research
A Case of Sporadic Pseudohypoparathyroidism Type 1B Presented with
Hypokalemia
Horm Metab Res DOI: 10.1055/a-1528-7471Luo et al. 1 reported two cases of autosomal
dominant pseudohypoparathyroidism type 1B (AD-PHP1B) and reviewed literature about
the genetic and epigenetic characteristics of AD-PHP1B. Pseudohypoparathyroidism
(PHP) is a cluster of heterogeneous diseases characterized by hypocalcemia and
hyperphosphatemia due to resistance to parathyroid hormone (PTH). PHP1B almost
results from methylation abnormalities of the maternal differentially methylated
regions (DMRs) and can be divided into sporadic PHP1B and AD-PHP1B 1. As mentioned ...
Source: Hormone and Metabolic Research - July 29, 2021 Category: Endocrinology Authors: Yang, Wen-jun Zhang, Qin Jin, Ping Tags: Letter to the Editor Source Type: research
Triglyceride-Glukose Index Predicts Adverse Events in Patients with
Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies
Horm Metab Res DOI: 10.1055/a-1518-7503The triglyceride-glucose (TyG) index, a recently proposed indicator for insulin
resistance, has been related with cardiovascular risks. We aimed to summarize
the association between TyG index and incidence of major adverse cardiovascular
events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies
demonstrating the association between TyG index and incidence of MACEs in ACS
patients with multivariate adjusted analyses were identified by search of
PubMed, Embase, and Web of Science databases. A random-effekt m...
Source: Hormone and Metabolic Research - July 23, 2021 Category: Endocrinology Authors: Li, Juying Ren, Ling Chang, Cheng Luo, Lin Tags: Endocrine Care Source Type: research
Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin
in Hypertensive Diabetic Patients with Nephropathy: A Randomized
Trial
Horm Metab Res 2021; 53: 470-477 DOI: 10.1055/a-1517-6643Angiogenesis is a multistep process implicated in the pathophysiology and
progression of diabetic nephropathy (DN). Angiotensin-converting enzyme
inhibitors (ACEI) and calcium channel blockers (CCB) have an important role in
DN. We performed a randomized-controlled trial of lisinopril alone (an ACEI) or
in combination with verapamil (a CCB) as a therapy for DN in type 2 diabetes
mellitus (T2DM) patients with hypertension (HTN) and urinary albumin creatinine
ratio (UACR) (30–300 mg/g) also to evaluate the...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Salem, Mohamed Sallam, Al-Aliaa M. Abdel-Aleem, Eman El-Mesallamy, Hala O. Tags: Endocrine Care Source Type: research
Prevalence of Primary Aldosteronism Across the Stages of Hypertension
Based on a New Combined Overnight Test
In conclusion, DCVT revealed that PA is a highly prevalent cause
of hypertension. DCVT could be employed as a diagnostic tool in all subjects
with arterial hypertension of unknown cause. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Voulgaris, Nick Tyfoxylou, Ernestini Vlachou, Sophia Kyriazi, Evagelia Gravvanis, Chris Kapsali, Chara Markou, Athina Papanastasiou, Labrini Gryparis, Alexandros Kassi, Eva Chrousos, George Kaltsas, Gregory Piaditis, George Tags: Endocrine Care Source Type: research
Age Moderates the Impact of TRAbs on Thyroid Hormones and Hepatic
Function in Patients with Graves ’ Disease
Horm Metab Res 2021; 53: 453-460 DOI: 10.1055/a-1510-9100Thyrotropin receptor antibodies (TRAbs) play a significant role in the course of
hepatic dysfunction (HDF) in patients with Graves’ disease (GD).
However, few studies have considered the factors that influence the
relationships among TRAbs, thyroid hormone levels, and hepatic function in
subjects with newly diagnosed GD. Here we investigated the associations of TRAbs
with thyroid hormones and hepatic function and assessed potential factors that
can influence these associations among patients with GD. A tot...
Source: Hormone and Metabolic Research - July 19, 2021 Category: Endocrinology Authors: Guo, Kai Ling, Hongwei Zhou, Xiaoyan Ying, Changjiang Tags: Endocrine Care Source Type: research
