Correction: Cumulative Effects of Thyroid Hormones Over 10 Years and Risk of General and Abdominal Obesity
Horm Metab Res DOI: 10.1055/a-1469-9144 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 19, 2021 Category: Endocrinology Authors: Mehran, Ladan Amouzegar, Atieh Gharibzadeh, Safoora Abdi, Hengameh Mansournia, Mohammad Ali Tohidi, Maryam Azizi, Fereidoun Tags: Erratum Source Type: research
Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism
Horm Metab Res DOI: 10.1055/a-1409-5310The contribution of PAX8 genetic variants to congenital hypothyroidism (CH) is not well understood. We aimed to study the genetic variability of exons 3 and 5 of PAX8 gene among a cohort of children with congenital hypothyroidism in correspondence to their clinical aspect. Blood samples were collected from 117 children (63 girls and 54 boys) with CH and enrolled as cases (Group I). All cases underwent biochemical confirmation with low FT4 and high TSH levels and thyroid gland imaging, along with equal number of matched apparently healthy individuals who served as controls (Group II). ...
Source: Hormone and Metabolic Research - April 16, 2021 Category: Endocrinology Authors: El-Ella, Sohier S. Abou Khattab, Essam Shawky A.E.H. Beddah, Rehab K. Barseem, Naglaa Fathy Tags: Endocrine Care Source Type: research
Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data
This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidenc...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Ma, Chaochao Li, Xiaoqi Liu, Lixin Cheng, Xinqi Xue, Fang Wu, Jie Xia, Liangyu Yin, Yicong Wang, Danchen Zou, Yutong Qiu, Ling Liu, Juntao Tags: Endocrine Care Source Type: research
Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study
Horm Metab Res 2021; 53: 245-256 DOI: 10.1055/a-1402-0183Multiple Endocrine Neoplasia type-1 (MEN1) is an autosomal dominant disorder
with a combined occurrence of tumours of parathyroid glands, pancreatic
islets, and anterior pituitary. About 90% of these patients carry
mutations in the MEN1 gene, though the spectrum is not well defined in
India. Forty clinically suspected cases of MEN1 were enrolled prospectively
over six years; 32 patients (23 index-cases and nine affected relatives)
with≥2 classical endocrine tumours of MEN1 were considered definite,
and eight were categorised as ‘MEN1-like’. Details of their
cli...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Shyamasunder, Asha Hesarghatta Pai, Rekha Ramamoorthy, Hemalatha Sakhti, Dhananjayan Manipadam, Marie Therese Kapoor, Nitin Paul, Thomas Vizhalil Jebasingh, Felix Thomas, Nihal Abraham, Deepak Thomas Paul, Mazhuvanchary Jacob Chacko, Ari George Prabhu, Kr Tags: Endocrine Care Source Type: research
Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy
Horm Metab Res 2021; 53: 211-218 DOI: 10.1055/a-1386-4512Thyroid-associated ophthalmopathy (TAO) is a potentially sight-threatening ocular disease. About 3–5% of patients with TAO have severe disease with intense pain, inflammation, and sight-threatening corneal ulceration or compressive optic neuropathy. The current treatments of TAO are often suboptimal, mainly because the existing therapies do not target the pathogenesis of the disease. TAO mechanism is unclear. Ocular fibrocytes express relatively high levels of the functional TSH receptor (TSHR), and many indirect evidences support its participation. Over expression...
Source: Hormone and Metabolic Research - April 14, 2021 Category: Endocrinology Authors: Ding, Yizhi Yang, Shaoqin Gao, Hua Tags: Review Source Type: research
Cumulative Effects of Thyroid Hormones Over 10 Years and Risk of General and Abdominal Obesity
Horm Metab Res DOI: 10.1055/a-1393-5864We aimed to assess if changes in thyrotropin (TSH) and free thyroxine (FT4) over 10 years of follow-up would be associated with changes in body mass index (BMI) and waist circumference (WC) or risk of obesity. We enrolled 2317 out of 4179 participants in Tehran Thyroid Study with serum TSH between 0.1–10 mU/l and without history of thyroid medication or surgery. Serum concentrations of FT4 and TSH were measured at baseline and three follow-ups (1999–2011). To account for within-subject correlation, the generalized estimating equation was used to assess the association between on...
Source: Hormone and Metabolic Research - March 23, 2021 Category: Endocrinology Authors: Mehran, Ladan Amouzegar, Atieh Gharibzadeh, Safoora Abdi, Hengameh Mansournia, Mohammadali Tohidi, Maryam Azizi, Fereidoun Tags: Endocrine Care Source Type: research
Association Between Metabolic Syndrome and All-Cause Mortality in Patients with Acute Coronary Syndrome: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-1381-8245The association between metabolic syndrome (MetS) and survival outcome after acute coronary syndrome (ACS) remains controversial. This meta-analysis sought to examine the association of MetS with all-cause mortality among patients with ACS. Two authors independently searched PubMed and Embase databases (from their inception to June 27, 2020) for studies that examined the association of MetS with all-cause mortality among patients with ACS. Outcome measures were in-hospital mortality and all-cause mortality during the follow-up. A total of 10 studies involving 49 896 ACS patients were ...
Source: Hormone and Metabolic Research - March 10, 2021 Category: Endocrinology Authors: Yang, Yong Shen, Haili Jin, Zhigeng Ma, Dongxing Zhao, Qing Zhang, Xuyi Tags: Original Articles Source Type: research
Polycystic Ovary Syndrome and Fibrocystic Breast Disease: An Updated Review
In conclusion, there is no clear association between benign breast disease and PCOS. Further studies on a large population with prospectively collected data using updated PCOS criteria are necessary. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 8, 2021 Category: Endocrinology Authors: Kunicki, Micha ł Smolarczyk, Roman Tags: Review Source Type: research
Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives
Horm Metab Res 2021; 53: 149-160 DOI: 10.1055/a-1380-4154Notwithstanding regulatory approval of lenvatinib and sorafenib to treat
radioiodine-refractory differentiated thyroid carcinoma (RAI-R DTC),
important questions and controversies persist regarding this use of these
tyrosine kinase inhibitors (TKIs). RAI-R DTC experts from German tertiary
referral centers convened to identify and explore such issues; this paper
summarizes their discussions. One challenge is determining when to start TKI
therapy. Decision-making should be shared between patients and
multidisciplinary caregivers, and should consider tumor size/burden,
...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Verburg, Frederik A. Amthauer, Holger Binse, Ina Brink, Ingo Buck, Andreas Darr, Andreas Dierks, Christine Koch, Christine K önig, Ute Kreissl, Michael C. Luster, Markus Reuter, Christoph Scheidhauer, Klemens Willenberg, Holger Sven Zielke, Andreas Schot Tags: Review Source Type: research
The transCampus Metabolic Training Programme Explores the Link of
SARS-CoV-2 Virus to Metabolic Disease
Horm Metab Res 2021; 53: 204-206 DOI: 10.1055/a-1377-6583Currently, we are experiencing a true pandemic of a communicable disease by the
virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and
unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to
enter our cells causing damage and disease. Our international research training
programme funded by the German Research Foundation has a clear mission to train
the best students wherever they may come from to learn to tackle the enormous
challenges of diabetes and its complicatio...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Bornstein, S. R. Guan, K. Brun ßen, C. Mueller, G. Kamvissi-Lorenz, V. Lechler, R. Trembath, R. Mayr, M. Poston, L. Sancho, R. Ahmed, S. Alfar, E. Aljani, B. Alves, T. C. Amiel, S. Andoniadou, C. L. Bandral, M. Belavgeni, A. Berger, I. Birkenfeld, A. Bon Tags: Commentary Source Type: research
Questions and Controversies in the Clinical Application of Tyrosine
Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated
Thyroid Carcinoma: Expert Perspectives
Horm Metab Res 2021; 53: 149-160 DOI: 10.1055/a-1380-4154Notwithstanding regulatory approval of lenvatinib and sorafenib to treat
radioiodine-refractory differentiated thyroid carcinoma (RAI-R DTC),
important questions and controversies persist regarding this use of these
tyrosine kinase inhibitors (TKIs). RAI-R DTC experts from German tertiary
referral centers convened to identify and explore such issues; this paper
summarizes their discussions. One challenge is determining when to start TKI
therapy. Decision-making should be shared between patients a...
Source: Hormone and Metabolic Research - March 2, 2021 Category: Endocrinology Authors: Verburg, Frederik A. Amthauer, Holger Binse, Ina Brink, Ingo Buck, Andreas Darr, Andreas Dierks, Christine Koch, Christine K önig, Ute Kreissl, Michael C. Luster, Markus Reuter, Christoph Scheidhauer, Klemens Willenberg, Holger Sven Zielke, Andreas Schot Tags: Review Source Type: research
Predicting the Relapse of Hyperthyroidism in Treated Graves ’ Disease with Orbitopathy by Serial Measurements of TSH-Receptor Autoantibodies
Horm Metab Res DOI: 10.1055/a-1373-5523The aim of this study was to investigate the potential of the new TSH-receptor antibody (TRAb) assays to predict remission or relapse of hyperthyroidism in patients with Graves’ disease (GD) and Graves’ orbitopathy (GO). TRAbs were measured retrospectively in sera from a cohort of GD patients with GO (n=117; remission n=38 and relapse n=79–Essen GO biobank) with automated binding immunoassays: TRAb Elecsys (Cobas Roche) and TRAb bridge assay (IMMULITE, Siemens), and the TSAb (thyroid stimulating Ab) cell-based bioassay (Thyretain, Quidel Corp.). To identify relapse risk/remissio...
Source: Hormone and Metabolic Research - February 22, 2021 Category: Endocrinology Authors: St öhr, Mareile Oeverhaus, Michael Lytton, Simon D. Horstmann, Mareike Zwanziger, Denise M öller, Lars Stark, Achim F ührer-Sakel, Dagmar Bechrakis, Nikolaos Berchner-Pfannschmidt, Utta Banga, J. Paul Philipp, Svenja Eckstein, Anja Tags: Endocrine Care Source Type: research
Long-Term Follow-Up of Denosumab Discontinuers with Multiple
Vertebral Fractures in the Real-World: A Case Series
Horm Metab Res DOI: 10.1055/a-1368-4218Denosumab discontinuation is associated with rapid reversal of bone turnover
suppression and with a considerable increase in fracture risk, including a
risk for multiple vertebral fractures (MVF). Long-term follow-up of patients
who sustained MVF after denosumab discontinuation has not been reported.
This case-series was aimed to provide a long-term follow-up on the
management and outcome of denosumab discontinuers who initially presented
with multiple vertebral fractures. Denosumab discontinuers were identified
...
Source: Hormone and Metabolic Research - February 15, 2021 Category: Endocrinology Authors: Tripto-Shkolnik, Liana Liel, Yair Yekutiel, Naama Goldshtein, Inbal Tags: Endocrine Care Source Type: research
Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy
We describe a retrospective assessment of subjects with diabetes, with and without COVID-19 infection, during the circuit breaker period of 7th April to 1st June 2020 managed through Tan Tock Seng Hospital’s telehealth platform. The virtual health applications consisted of telephone consultations, video telehealth visits via smartphones, and remote patient monitoring. The TTSH team intensively managed 298 diabetes patients using a telehealth strategy. The group comprised of (1) 84 inpatient COVID-19 patients with diabetes who received virtual diabetes education and blood glucose management during their hospitalisation an...
Source: Hormone and Metabolic Research - February 2, 2021 Category: Endocrinology Authors: Lian, Xia Dalan, Rinkoo Seow, Cherng Jye Liew, Huiling Jong, Michelle Chew, Daniel Lim, Brenda Lin, Anita Goh, Eunice Goh, Christina Othman, Noorani Bte Tan, Lucy Boehm, Bernhard O. Tags: Endocrine Care Source Type: research
Genetic and Epigenetic Characteristics of Autosomal Dominant Pseudohypoparathyroidism Type 1B: Case Reports and Literature Review
In this study, 3.0 kb STX16 deletion causes isolated LOM at exon A/B in two families, which is the most common genetic mutation of AD-PHP1B. The deletion involving NESP55 or AS or genomic rearrangements of GNAS can also result in AD-PHP1B, but it's rare. LOM at exon A/B DMR is prerequisite methylation defect of AD-PHP1B. STX16 and NESP55 directly control the imprinting at exon A/B, while AS controls the imprinting at exon A/B by regulating the transcriptional level of NESP55. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full...
Source: Hormone and Metabolic Research - January 29, 2021 Category: Endocrinology Authors: Luo, Dandan Qi, Xiangyu Liu, Luna Su, Yu Fang, Li Guan, Qingbo Tags: Review Source Type: research
