A Century After the Description of “Hormones”, Our Golden Jubilee Celebration Goes on with What is New in Endocrine Oncology: And a Lot is New!
Horm Metab Res 2020; 52: 551-552 DOI: 10.1055/a-1217-1529About 3000 thousand years ago Marcus Aurelius said: “Time is a sort of river of passing events, and strong is its current; no sooner is a thing brought to sight than it is swept by and another takes its place, and this too will be swept away…” 1. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - August 12, 2020 Category: Endocrinology Authors: Stratakis, Constantine A. Tags: Editorial Source Type: research

Severe Hypocalcemia and Transient Hypoparathyroidism After Hyperthermic Intraperitoneal Chemotherapy
Horm Metab Res DOI: 10.1055/a-1220-6971Dear Editors,Hypocalcemia is not unusual in patients hospitalized for critical illness and has also been described after general surgery in addition to head and neck surgical procedures 1 2 3. Hypocalcemic events commonly occur in the setting of massive blood transfusion, albumin deficiency, vitamin D deficiency, and/or hypomagnesemia. In the absence of these factors, only slight decreases in calcium levels within the normal range have been reported during surgical procedures 1. Cytoreductive surgery with ...
Source: Hormone and Metabolic Research - August 6, 2020 Category: Endocrinology Authors: Tharmalingam, Senthuran Reddy, Sanjay Sharda, Pankaj Koch, Christian A. Tags: Letter to the Editor Source Type: research

No Independent Association of Circulating Fetuin-A with Insulin Sensitivity in Young Women
Horm Metab Res DOI: 10.1055/a-1216-4405Animal data link high circulating fetuin-A to low insulin sensitivity and observational studies identify the hepatokine as a marker of future incident type 2 diabetes mellitus in humans. However, a recent, well-powered Mendelian randomization study finds no causal role. We therefore tested in a deeply-phenotyped human cohort if circulating fetuin-A correlates independently with insulin sensitivity and how it relates to the metabolic syndrome and ectopic fat deposition. We analyzed data from 290 young women with and without ...
Source: Hormone and Metabolic Research - August 5, 2020 Category: Endocrinology Authors: Reif, Sabrina Moschko, Sarah Gar, Christina Ferrari, Uta Hesse, Nina Sommer, Nora N. Sei ßler, Jochen Lechner, Andreas Tags: Endocrine Care Source Type: research

Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by Somatolactotroph Tumours
Horm Metab Res DOI: 10.1055/a-1207-1132The aim of this study is to assess differences in patient characteristics, tumour characteristics and hormone levels between acromegalic patients with and without hyperprolactinemia. 44 patients of the University Hospital of Brussels, Belgium with acromegaly who were diagnosed between January 2007 and July 2018 were included in this study. Nineteen patients were classified in the hyperprolactinemia group and 25 patients were classified in the normoprolactinemia group. No significant differences between acromegalic...
Source: Hormone and Metabolic Research - August 4, 2020 Category: Endocrinology Authors: Van Laethem, Delphine Michotte, Alex Cools, Wilfried Velkeniers, Brigitte Unuane, David Andreescu, C. E. Bravenboer, Bert Tags: Endocrine Care Source Type: research

Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism
Horm Metab Res DOI: 10.1055/a-1177-6814Adult patients with a dysfunctional ether-a-go-go 2 (hERG2) protein, which is encoded by the KCNH6 gene, present with hyperinsulinemia and hyperglycemia. However, the mechanism of KCNH6 in glucose metabolism disorders has not been clearly defined. It has been proposed that sustained endoplasmic reticulum (ER) stress is closely concerned with hepatic insulin resistance and inflammation. Here, we demonstrate that Kcnh6 knockout (KO) mice had impaired glucose tolerance and increased levels of hepatic apoptosis, in addi...
Source: Hormone and Metabolic Research - August 3, 2020 Category: Endocrinology Authors: Lu, Jing Shen, Han Li, Qi Xiong, Feng-Ran Yuan, Ming-Xia Yang, Jin-Kui Tags: Endocrine Research Source Type: research