Incretins Enhance PGF2 α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts
Horm Metab Res 2022; 54: 42-49 DOI: 10.1055/a-1713-7967Incretins including glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1), which are secreted from the small intestine
after oral food ingestion, are currently well-known to stimulate insulin
secretion from pancreatic β-cells and used for the treatment of type 2
diabetes mellitus. We have previously reported that prostaglandin
F2α (PGF2α) stimulates the synthesis
of interleukin-6 (IL-6) and osteoprotegerin in osteoblast-like MC3T3-E1 cells,
and that IL-6 and osteoprotegerin release are mediated through the
p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP kinase or
stress-activated protein kinase/c-Jun N-terminal kinase
(SAPK/JNK) pathways. In the present study, we investigated the effects
of incretins including GLP-1 and GIP, on the PGF2α-induced
synthesis of IL-6 and osteoprotegerin and examined the detailed mechanism in
osteoblast-like MC3T3-E1 cells. We found that GIP and GLP-1 significantly
stimulated the PGF2α-induced synthesis of IL-6 in
osteoblast-like MC3T3-E1 cells. In addition, GIP and GLP-1 significantly
enhanced the PGF2α-induced mRNA expression levels of IL-6. On
the other hand, GIP and GLP-1 markedly stimulated the
PGF2α-induced synthesis of osteoprotegerin. However, the
ph...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Hioki, Tomoyuki Kuroyanagi, Gen Fujita, Kazuhiko Sakai, Go Kawabata, Tetsu Kim, Woo Tachi, Junko Matsushima-Nishiwaki, Rie Iida, Hiroki Kozawa, Osamu Tokuda, Haruhiko Tags: Endocrine Research Source Type: research
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