Identification of Key Genes and Related Drugs of Adrenocortical
Carcinoma by Integrated Bioinformatics Analysis
This study aims to discover biomarkers and potential
therapeutic agents for ACC through bioinformatics, enhancing clinical diagnosis
and treatment strategies. Differentially expressed genes (DEGs) between ACC and
normal adrenal cortex were screened out from the GSE19750 and GSE90713 datasets
available in the GEO database. An online Venn diagram tool was utilized to
identify the common DEGs between the two datasets. The identified DEGs were
subjected to functional assessment, pathway enrichment, and identification of
hub genes by performing the protein-pr...
Source: Hormone and Metabolic Research - December 18, 2023 Category: Endocrinology Authors: Wei, Jian-bin Zeng, Xiao-chun Ji, Kui-rong Zhang, Ling-yi Chen, Xiao-min Tags: Original Article: Endocrine Research Source Type: research
Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid
Metabolism in Hyperlipidemic Mice
In conclusion, PDK4 has a diagnostic effect on dyslipidemia in
children, while lipid metabolism in hyperlipidemic mice could be mitigated by
upregulation of PDK4, which was inhibited by miR-107, miR-27a-3p and miR-106b-5p
on upstream. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 14, 2023 Category: Endocrinology Authors: Cai, Wenjuan Wang, Xin Deng, Qian Gao, Jian Chen, Yuqing Tags: Original Article: Endocrine Research Source Type: research
The Fate of Angiotensin II in Placental Tissue and
Blood
Horm Metab Res DOI: 10.1055/a-2202-3894The existence of a non-canonical pathway of renin-angiotensin system in the blood
pressure control system has been highlighted over the past three decades. The
enzymes involved in this pathway include a series of angiotensinases such as
neprilysin (NEP), aminopeptidase A (APA), carboxypeptidase, and angiotensin
converting enzyme 2. The physiological roles of these peptidases have been
reconsidered in this study, based on the publications of other research groups
and the results from our previous study, regarding the liberatio...
Source: Hormone and Metabolic Research - December 11, 2023 Category: Endocrinology Authors: Mizutani, Shigehiko Mizutani, Hidesuke Mizutani, Eita Arita, Harumasa Kajiyama, Hiroaki Tags: Review Source Type: research
Metabolic Syndrome Components in Patients with Pituitary
Adenoma
The objective of this review is to explore the possible mechanisms
through which PAs contributes to MetSx. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 11, 2023 Category: Endocrinology Authors: Gonzalez-Almazan, Jorge A. Cortes-Contreras, Ana Paula Flores-Rabasa, Regina Mendez-Garcia, Lucia A. Escobedo, Galileo Navarro Olvera, Jos é L. Carrillo-Ruiz, Jos é D. Tags: Review Source Type: research
Unawareness of Primary Aldosteronism as a Common Cause of Hypokalemia – Insights from the IPAHK+ Trial (Incidence of
Primary Aldosteronism in Patients with Hypokalemia)
Horm Metab Res DOI: 10.1055/a-2204-3163Hypokalemia plays an important role in the diagnosis and management of primary
aldosteronism (PA). While the hypokalemic variant of the disease accounts for
about one third of all cases, little is known about the incidence of PA in
hypokalemic populations. The IPAHK+ study is an epidemiological,
cross-sectional trial to provide evidence on the incidence of PA in hypokalemic
patients from a university hospital outpatient population. Recruitment of
outpatients with hypokalemia≤3 mmol/l is carried out on
a continuo...
Source: Hormone and Metabolic Research - December 11, 2023 Category: Endocrinology Authors: Gruber, Sven Stasi, Evangelia Pion, Antonio Boan Steiner, Regula Erlic, Zoran Bornstein, Stefan R. Sudano, Isabella Reincke, Martin Beuschlein, Felix Tags: Original Article: Endocrine Care Source Type: research
FAF1 Gene Involvement in Pituitary Corticotroph
Tumors
In conclusion, we identified two
FAF1 variants in patients diagnosed with CD with a potential
pathogenic effect on the protein function and structure. Our in vitro and in
vivo studies did not reveal an association of FAF1 defects with pituitary
tumorigenesis and further studies may be needed to understand any
association. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - December 8, 2023 Category: Endocrinology Authors: Nguyen, Matthew Maria, Andrea Gutierrez Faucz, Fabio R. Trivellin, Giampaolo Stratakis, Constantine A. Tatsi, Christina Tags: Original Article: Endocrine Research Source Type: research
Desmopressin Dose Requirements in Adults with Congenital and Acquired
Central Diabetes Insipidus
Horm Metab Res DOI: 10.1055/a-2198-7207Central diabetes insipidus is a rare disorder characterized by a deficiency of
vasopressin. The first line drug to treat this disorder is a synthetic analogue
of vasopressin, desmopressin.The primary aim of this retrospective register
study was to compare desmopressin dose requirements in patients with acquired
and congenital DI, and secondly to assess the influence of BMI on dose
requirement and risk of hyponatremia with different drug administrations. We
included all patients with suspected DI attending the endocrine depart...
Source: Hormone and Metabolic Research - December 8, 2023 Category: Endocrinology Authors: Pedersen, Aslak Nykj ær Andreassen, Mikkel Rasmussen, Aase Krogh Krogh, Jesper Tags: Original Article: Endocrine Care Source Type: research
Influence of Metabolic Syndrome on the Long-Term Prognosis of
Patients with Myocardial Infarction: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2196-3764The influence of metabolic syndrome (MetS) on long-term prognosis of patients
with myocardial infarction (MI), the most severe type of coronary artery
disease, remains not fully determined. This systematic review and meta-analysis
were conducted to investigate the association between MetS and long-term
clinical outcomes of patients with MI. A systematic search of Medline, Web of
Science, and Embase databases from inception to June 25, 2023, was conducted to
obtain eligible studies. Only studies with follow-up duration for at ...
Source: Hormone and Metabolic Research - December 6, 2023 Category: Endocrinology Authors: Chen, Tianfeng Shi, Zhewei Qian, Caizhen Tags: Original Article: Endocrine Care Source Type: research
Bone Mineral Density and Vitamin D Status in Patients with Autoimmune
Polyglandular Syndromes: A Single Tertiary Care Center
Experience
This study evaluated the vitamin D level and BMD of patients with
APS. We performed a cross-sectional study on 44 patients with APS and 55 age and
gender-matched control subjects. Among patients with APS, 14 were classified as
APS-2 [Addison’s disease (AD)+autoimmune thyroid disease (ATD)
and/or type 1 diabetes(T1D)]. In contrast, the other 30 were APS-3
(ATD+T1D+other autoimmune diseases). Serum samples were analyzed
for vitamin D levels. The lumbar spine and femoral neck BMD were measured by
dual X-ray absorptiometry. Z-scores were obtained by compar...
Source: Hormone and Metabolic Research - December 6, 2023 Category: Endocrinology Authors: Akkurt Kocaeli, Aysen Erturk, Erd ınc Tags: Original Article: Endocrine Care Source Type: research
LncRNA H19 Influences Cellular Activities via the
miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma
Horm Metab Res DOI: 10.1055/a-2196-3511Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy threatening
patients’ life quality. Our previous study has demonstrated that
inhibition of long non-coding RNA H19 (lncRNA h19; H19) blocks ATC growth and
metastasis. The current study aimed to further explore the potential mechanism
of H19 in ATC. Expression of H19, miR-454-3p, and BHLHE40 mRNA was measured
using RT-qPCR in tissue samples and cell lines. The dual-luciferase reporter
assay and Pearson correlation analysis were used to explore the interaction
...
Source: Hormone and Metabolic Research - December 5, 2023 Category: Endocrinology Authors: Wu, Yang Yang, Jihua Zhang, Honglai Cheng, Jingjing Lei, Peijie Huang, Jianyuan Tags: Original Article: Endocrine Research Source Type: research
DNA Methylation Status of HYAL1 in Malignant and Benign
Thyroid Nodules
Horm Metab Res 2023; 55: 869-875 DOI: 10.1055/a-2188-0050Differentiation between benign and malignant thyroid nodules has been a challenge
in clinical practice. Exploring a novel biomarker to determine the malignancy of
thyroid nodules has important implications. We semi-quantitatively determined
the DNA methylation levels of four CpG sites located at the gene body of HYAL1
in formalin-fixed paraffin-embedded (FFPE) tissue samples from 190 early-stage
papillary thyroid cancer (PTC) cases and 190 age- and gender-matched subjects
with benign thyroid nodule (BTN). HY...
Source: Hormone and Metabolic Research - December 1, 2023 Category: Endocrinology Authors: Li, Mengxia Yin, Yifei Zhang, Minmin Jiang, Chenxia Li, Hong Yang, Rongxi Tags: Original Article: Endocrine Research Source Type: research
Bone Metastases in Patients with Pancreatic NETs: Prevalence and
Prognosis
Horm Metab Res 2023; 55: 827-834 DOI: 10.1055/a-2159-5548The clinical relevance of bone metastases (BM) in advanced pancreatic
neuroendocrine tumors (PanNETs) is poorly described. We analyzed 314 consecutive
PanNET patients treated at the European Neuroendocrine Tumour Society (ENETS)
Center Essen between 2009 and 2021 in terms of the occurrence and clinical and
prognostic impact of BM using hybrid imaging with 68Ga-DOTATOC PET/CT.
According to UICC staging, 171/314 (54.5%) patients had stage IV
PanNETs. BM was diagnosed in 62/171 (36.3%) patients. Initially,
...
Source: Hormone and Metabolic Research - December 1, 2023 Category: Endocrinology Authors: Mathew, Annie Fendler, Wolfgang P. Theysohn, Jens Herrmann, Ken F ührer, Dagmar Lahner, Harald Tags: Original Article: Endocrine Care Source Type: research
Thyroid Diseases and Intestinal Microbiome
Horm Metab Res 2023; 55: 813-818 DOI: 10.1055/a-2190-3847The human microbiome plays an integral role in health. In particular, it is
important for the development, differentiation, and maturation of the immune
system, 70% of which resides in the intestinal mucosa. Microbiome
studies conducted to date have revealed an association between disturbances in
the microbiota (dysbiosis) and various pathological disorders, including changes
in host immune status. Autoimmune thyroid diseases are one of the most common
organ-specific autoimmune disorders, with a worldwide pr...
Source: Hormone and Metabolic Research - December 1, 2023 Category: Endocrinology Authors: Legakis, Ioannis Chrousos, George P. Chatzipanagiotou, Stylianos Tags: Review Source Type: research
Correction: Association Between Metabolic Syndrome and the Risk of Lung Cancer: A
Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2211-2166 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - November 27, 2023 Category: Endocrinology Authors: Zhang, Zhao Liu, Qinxiang Huang, Congcong Wu, Jun Wen, Yingsheng Tags: Erratum Source Type: research
The Influence of Hyperglycemia on Liver Triglyceride Deposition in
Partially Pancreatectomized Rats
Horm Metab Res DOI: 10.1055/a-2198-1132Nonalcoholic fatty liver disease and diabetes always coexist. The relationship of
fatty liver and hyperglycemia is not clear. We studied the influence of
hyperglycemia on triglyceride (TG) accumulation in the liver and explored its
possible mechanisms. SD rats were divided into three groups: Group A (sham
operation control), Group B (partially pancreatectomized rats), and Group C
(partially pancreatectomized rats treated with insulin). At 4 weeks after
surgery, pancreatic weights and liver TG contents were measured. Serum
...
Source: Hormone and Metabolic Research - November 22, 2023 Category: Endocrinology Authors: Bai, Xiu-Ping Li, Ting-Ting Guo, Lai-Li Wang, Jing Dong, Feng Tags: Original Article: Endocrine Research Source Type: research
