Unawareness of Primary Aldosteronism as a Common Cause of Hypokalemia – Insights from the IPAHK+ Trial (Incidence of Primary Aldosteronism in Patients with Hypokalemia)
Horm Metab Res DOI: 10.1055/a-2204-3163Hypokalemia plays an important role in the diagnosis and management of primary
aldosteronism (PA). While the hypokalemic variant of the disease accounts for
about one third of all cases, little is known about the incidence of PA in
hypokalemic populations. The IPAHK+ study is an epidemiological,
cross-sectional trial to provide evidence on the incidence of PA in hypokalemic
patients from a university hospital outpatient population. Recruitment of
outpatients with hypokalemia≤3 mmol/l is carried out on
a continuous referral-basis through an automated data delivery system. Up to an
interim data closure, 66 patients underwent the study protocol. The mean age of
the participants was 52.9±1.5 years with an equal sex ratio of 1:1 women
to men, a mean potassium value of 2.78±0.31 mmol/l
[1.8;3.0] and a prevalence of arterial hypertension of 72.7%. PA was
diagnosed in 46.6% of all participants, all of whom had a history of
hypertension. Incidence of PA increased continuously with decreasing potassium
levels with proportions of 26.7%, 50% and 57.1% in the
subgroups of 3.0 mmol/l (n=15),
2.8–2.9 mmol/l (n=22)
and≤2.7 mmol/l (n=21), respectively. Prior to
testing, 59.1% of all patients presented at least with one plausible
other cause of hypoka...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Gruber, Sven Stasi, Evangelia Pion, Antonio Boan Steiner, Regula Erlic, Zoran Bornstein, Stefan R. Sudano, Isabella Reincke, Martin Beuschlein, Felix Tags: Original Article: Endocrine Care Source Type: research
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