Risk Factors Analysis of Severe Liver Injury Induced by Statins
Horm Metab Res DOI: 10.1055/a-2210-3395The aim of this study is to report the risk factors of severe statin induced
liver injury (SILI). From the database of Shandong ADR Monitoring Center and
Outpatients and inpatients in our hospital, SILI cases reported from 2013 to
2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion
and exclusion criteria of severe and general SILI were established separately.
After the SILI cases were selected and confirmed, the socio-demographic and
clinical characteristics were collected. Single factor chi-square test and
multi-factor unconditional logistic regression analysis were used to analyze the
influencing factors of severe SILI. From 1391 reported cases, 1211 met SILI
diagnostic criteria, of which 157 were severe SILI and 964 were general SILI.
Univariate analysis showed that age, drug combination, statin category were the
influencing factors of severe SILI (p<0.1). Multivariate logistic
analysis showed that drug combination and statin category were the influencing
factors of severe SILI (p<0.05). Atorvastatin caused the most serious
SILI, and its risk is 1.77 times higher than rosuvastatin. The serious SILI risk
of drug combination was 2.08 times higher than statin alone. The patient with
these factors should be monitored intensively during clinical tr...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Su, Feng-yun Li, Wen-hua Zhao, Xu-dong Han, Qian Xu, Xin Geng, Tao Tags: Original Article: Endocrine Care Source Type: research
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