Salt and Aldosterone – Reciprocal and Combined Effects in Preclinical Models and Humans
Horm Metab Res DOI: 10.1055/a-2172-7228Primary aldosteronism is an endocrine disorder caused by excessive production of
aldosterone by the adrenal glands, and is recognized as the most important cause
of endocrine hypertension. With specific therapy, this type of hypertension is
potentially curable. In the general population, high salt intake increases the
risk for cardiovascular diseases like stroke. In populations with aldosterone
excess, observational and experimental data suggest that aldosterone-induced
organ damage requires a combination of high dietary salt intake and high plasma
aldosterone, i.e., plasma aldosterone levels inappropriately high for salt
status. Therefore, understanding the relationship between plasma aldosterone
levels and dietary salt intake and the nature of their combined effects is
crucial for developing effective prevention and treatment strategies. In this
review, we present an update on findings about primary aldosteronism and salt
intake and the underlying mechanisms governing their interaction. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Chen, Li Adolf, Christian Reincke, Martin Schneider, Holger Tags: Review Source Type: research
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