LncRNA LINC01339 Hinders the Development of Wilms ’ Tumor via MiR-135b-3p/ADH1C Axis
This study intended to investigate how a novel long non-coding
RNA LINC01339 functions in the pathogenesis of Wilms’ tumor. An elevated
miR-135b-3p expression as well as reduced levels of LINC01339 and ADH1C were
observed in Wilms’ tumor. LINC01339 mediated ADH1C expression by
directly binding to miR-135b-3p. The enforced LINC01339 or ADH1C markedly
hindered cell growth and migration in Wilms’ tumor. The LINC01339
overexpression also repressed the growth of Wilms’ tumors in vivo,
whereas miR-135b-3p overexpression exerted the opposite effects on
Wilms’ tumor cells in vitro. Additionally, upregulating miR-135b-3p
reversed LINC01339’s effects on the cellular processes of Wilms’
tumor cells, whereas ADH1C overexpression offset the cancer-promoting influence
of miR-135b-3p upregulation on Wilms’ tumor progression. Therefore,
LINC01339 prevents Wilms’ tumor progression by modulating the
miR-135b-3p/ADH1C axis. Our findings substantiate that the
LINC01339/miR-135 b-3p/ADH1C regulatory axis has potential to be
a target for the treatment of Wilms’ tumor. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Yu, Yang Liu, Yanfei Tags: Original Article: Endocrine Research Source Type: research
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