Association Between Remnant Cholesterol and Risk of Hyperuricemia: A Cross-Sectional Study
Horm Metab Res DOI: 10.1055/a-2299-2914Remnant cholesterol (RC) is closely related to metabolic diseases. Our study aims
to explore the relationship between RC and hyperuricemia. This cross-sectional
study included 14 568 adults aged 20 years or older from the National Health and
Nutrition Examination Survey (NHANES) conducted between 2007 and 2018 in the
United States. RC is calculated by subtracting high-density lipoprotein
cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) from total
cholesterol (TC). Hyperuricemia is defined by serum uric acid (SUA)
levels≥7 mg/dl in men and≥6 mg/dl in women. The independent association between
RC and hyperuricemia was evaluated. As the quartile range of RC levels
increases, the prevalence of hyperuricemia also rises (7.84% vs. 13.71% vs.
18.61% vs. 26.24%, p<0.001). After adjusting for confounding factors, the
fourth quartile of RC was associated with an increased risk of hyperuricemia
compared with the first quartile (OR=2.942, 95% CI 2.473–3.502, p<0.001).
Receiver Operating Characteristic (ROC) analysis shows that RC outperforms other
single lipid indices in hyperuricemia. Further Restricted Cubic Splines (RCS)
analysis suggests a nonlinear relationship between RC levels and hyperuricemia.
Elevated RC levels were found to be linked to hyperurice...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Wang, Zhaoxiang Wu, Menghuan Yan, Han Zhong, Shao Xu, Ruijun Zhao, Zhiyong Yang, Qichao Tags: Original Article: Endocrine Care Source Type: research