Reimagining human ARTs: from revolutions to evolution
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 14, 2024 Category: Reproduction Medicine Source Type: research

Culture media affect sex after IVF treatment —a detailed analysis of explanatory variables
ConclusionMore male children were born after culture in Sage media compared to G-TL media. Male embryo development was affected by culture media. Our observations suggest that culture media impact male embryo quality selectively, thus potentially favoring the selection of male embryos. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 13, 2024 Category: Reproduction Medicine Source Type: research

Live birth outcomes following single-step blastocyst warming technique – optimizing efficiency without impacting live birth rates
ConclusionsThe study found equivalent outcomes for SS and SW in all parameters except for a slight rise in the rate of multiple gestations. The results suggest that SS warming is an efficient, viable alternative to SW, reducing thaw times without adverse effects on live birth rates or neonatal birth weights. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 13, 2024 Category: Reproduction Medicine Source Type: research

Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives
ConclusionA gap exists between clinician and patient attitudes toward PES; clinicians generally maintained reservations about such screening and patients indicated interest in it. Clinicians and patients sometimes imagined using PES to prepare for the birth of a predisposed or “affected” individual—a rationale that is often associated with prenatal testing. Many clinicians and patients held different attitudes depending on what is specifically screened, despite the sometimes blurry distinction between conditions and traits. Considerations raised by clinicians and pa tients may help guide professional societies in dev...
Source: Journal of Assisted Reproduction and Genetics - March 12, 2024 Category: Reproduction Medicine Source Type: research

Preimplantation genetic testing for monogenic disorders (PGT-M) offers an alternative strategy to prevent children from being born with hereditary neurological diseases or metabolic diseases dominated by nervous system phenotypes: a retrospective study
ConclusionsThis study highlights the importance of PGT-M in preventing children born with hereditary neurological diseases or metabolic diseases dominated by nervous system phenotypes. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 12, 2024 Category: Reproduction Medicine Source Type: research

WISE: whole-scenario embryo identification using self-supervised learning encoder in IVF
ConclusionSSL methods can improve embryo identification accuracy even when dealing with cross-device and cryo-thawed paired images. The study is the first to apply SSL in embryo identification, and the results show the promise of WISE for future application in embryo witnessing. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 12, 2024 Category: Reproduction Medicine Source Type: research

Association between blood lead levels and unfavorable IVF outcomes: potential involvement of endoplasmic reticulum stress response in granulosa cells
ConclusionsBLLs are negatively associated with final clinical outcomes in IVF patients that may be related to increased ER stress response and GC apoptosis. Thus, reducing Pb exposure before IVF procedures may improve final success rates. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 12, 2024 Category: Reproduction Medicine Source Type: research

Ovulation induction and subfertile untreated conception groups offer improved options for interpreting risks associated with ART
ConclusionOI and subfertile untreated conception groups offer improved options for interpreting health outcomes in ART births. Pregnancy complications (particularly placental disorders) and adverse outcomes at delivery are more common following ART. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 12, 2024 Category: Reproduction Medicine Source Type: research

Psychological distress, vaccine, and booster acceptance in women considering or undergoing fertility treatments during the Omicron surge of the COVID-19 pandemic
ConclusionThe majority of women in this study were vaccinated and had received their booster dose but also with clinically significant levels of depression. Patients with higher levels of distress and greatest medical mistrust demonstrated a concern that the Omicron variant would delay treatment, lead to suboptimal fertility outcomes, and COVID-19 vaccination would impact risk of miscarriages. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 9, 2024 Category: Reproduction Medicine Source Type: research

Meta-analysis of endometrial transcriptome data reveals novel molecular targets for recurrent implantation failure
ConclusionIn summary, the meta-signature genes hold promise for improving RIF patient identification and facilitating the development of personalized treatment strategies, illuminating the multifaceted nature of this complex condition. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 8, 2024 Category: Reproduction Medicine Source Type: research

Mining phase separation-related diagnostic biomarkers for endometriosis through WGCNA and multiple machine learning techniques: a retrospective and nomogram study
ConclusionsThis study suggests the potential involvement of phase separation-related genes in the pathogenesis of endometriosis (EMs) and identifies promising biomarkers for diagnosis. These findings have implications for further research and the development of new therapeutic strategies for EMs. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 8, 2024 Category: Reproduction Medicine Source Type: research

Correction to: Optimizing non ‑invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non‑invasive PGT‑A results
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 7, 2024 Category: Reproduction Medicine Source Type: research

High resolution dynamic ultrasound atlas of embryonic and fetal development of the common marmoset
ConclusionThe temporal and spatial resolution of ultrasound achieved in this study demonstrates the promise of noninvasive imaging in the marmoset for the in vivo study of primate-specific aspects of embryonic and fetal development. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 6, 2024 Category: Reproduction Medicine Source Type: research