Oncofertility case report: live birth 10 years after oocyte in vitro maturation and zygote cryopreservation
ConclusionsIn cases where urgency to start adjuvant therapy requires immediate oocyte collection, IVM may be the only option to obtain fully competent mature oocytes allowing for effective preservation of the reproductive potential. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 28, 2020 Category: Reproduction Medicine Source Type: research

Closing the circle of reverse genetics in reproductive medicine
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 27, 2020 Category: Reproduction Medicine Source Type: research

Is intrauterine insemination a viable treatment option for women over 43  years old? An analysis by ovarian stimulation protocol and sperm source
ConclusionsThe use of intrauterine inseminations in women 43  years of age and older is an ineffective treatment strategy. This is irrespective of the use of ovarian stimulation or donor sperm. Costly gonadotropin injections did not increase the chance of pregnancy nor did oral medication when compared to natural cycle IUIs. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 26, 2020 Category: Reproduction Medicine Source Type: research

Maternal age is associated with embryo splitting after single embryo transfer: a retrospective cohort study
ConclusionAdvanced maternal age was associated with a lower rate of MZT. A threshold female age of 36  years existed for lower MZT. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 23, 2020 Category: Reproduction Medicine Source Type: research

Next-generation sequencing: a follow-up of 36,913 singleton pregnancies with noninvasive prenatal testing in central China
ConclusionNIPT is highly sensitive and has a low false positive rate in testing clinically significant fetal aneuploidies of general reproductive women. However, this technique cannot substitute for  amniocentesis and karyotyping, and detailed genetic counseling is also essential for the high-risk group of NIPT. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 23, 2020 Category: Reproduction Medicine Source Type: research

The genetic cause of intellectual deficiency and/or congenital malformations in two parental reciprocal translocation carriers and implications for assisted reproduction
ConclusionsSystematic genetic diagnosis of two carriers of inherited chromosomal translocations accompanied by clinical phenotypes revealed their cause of disease, which was critical for genetic counseling and further ART for these families. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 22, 2020 Category: Reproduction Medicine Source Type: research

Letter to editor
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 22, 2020 Category: Reproduction Medicine Source Type: research

The effect of laser-assisted hatching on the methylation and expression pattern of imprinted gene IGF2/H19 in mouse blastocysts and offspring
ConclusionThese observations suggested that drilling used for hatching of in vitro cultured mouse  blastocysts may improve the production of offspring. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 21, 2020 Category: Reproduction Medicine Source Type: research

Equal opportunity for all? An analysis of race and ethnicity in fertility preservation in New York City
AbstractPurposeTo compare the racial and ethnic make-up of patients who accessed medically indicated fertility preservation services (MIFP) against the overall racial diversity (including Hispanic origin) across women of reproductive age diagnosed with cancer in New York City (NYC).MethodsAll patients who completed at least one MIFP between January 2017 and December 2018 were reviewed. Race was self-reported. A calculation of the expected racial distribution across women of reproductive age with cancer in NYC was determined using the most recent NYC census data. Statistical analysis included chi-square goodness of fit and ...
Source: Journal of Assisted Reproduction and Genetics - October 21, 2020 Category: Reproduction Medicine Source Type: research

Double trouble? Impact of frozen embryo transfer on the monozygotic twinning rate: a retrospective cohort study from 8459 cycles
ConclusionsFrozen ET is associated with a lower risk of MZT. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 20, 2020 Category: Reproduction Medicine Source Type: research

Antenatal antioxidants to avert autism?
AbstractPaternally derivedde novo mutations (DNMs) caused by oxidative stress (OS) have been implicated in the development of autism spectrum disorders (ASDs). Whether preconception antioxidant supplementation can reduce the incidence of ASDs by reducing OS is an area of uncertainty and potentially important future scientific investigation. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 20, 2020 Category: Reproduction Medicine Source Type: research

The effect of ICSI in infertility couples with non-male factor: a systematic review and meta-analysis
ConclusionICSI has no obvious advantage in patients with normal semen parameters. Enough information is still not available to prove the efficacy of ICSI in couples with non-male factor infertility comparing to IVF. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 19, 2020 Category: Reproduction Medicine Source Type: research

Treatment with Laevo ( l )-carnitine reverses the mitochondrial function of human embryos
Conclusion(s)l-carnitine is a promising culture medium supplement that might be able to counteract the decreased mitochondrial function in human morula stage embryos. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 17, 2020 Category: Reproduction Medicine Source Type: research

Ageing and ovarian stimulation modulate the relative levels of transcript abundance of oocyte DNA repair genes during the germinal vesicle-metaphase II transition in mice
AbstractPurposeOocyte quality and reproductive outcome are negatively affected by advanced maternal age, ovarian stimulation and method of oocyte maturation during assisted reproduction; however, the mechanisms responsible for these associations are not fully understood. The aim of this study was to compare the effects of ageing, ovarian stimulation and in-vitro maturation on the relative levels of transcript abundance of genes associated with DNA repair during the transition of germinal vesicle (GV) to metaphase II (MII) stages of oocyte development.MethodsThe relative levels of transcript abundance of 90 DNA repair-assoc...
Source: Journal of Assisted Reproduction and Genetics - October 17, 2020 Category: Reproduction Medicine Source Type: research

Is there a critical LH level for hCG trigger after the detection of LH surge in modified natural frozen-thawed single blastocyst transfer cycles?
ConclusionOur study suggests that hCG can be administered at any time between the start of LH rise ( ≥ 15 IU/L) and LH peak level (≥ 40 IU/L) without a detrimental effect on clinical outcome. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 14, 2020 Category: Reproduction Medicine Source Type: research

Length of ovarian stimulation does not impact live birth rate in fresh donor oocyte cycles: a SART CORS study
ConclusionsLBR is significantly decreased in fresh donor oocyte cycles when cycles are prolonged with high total GN dose. However, after controlling for confounders neither DOS nor total GN dose significantly affects LBR. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 12, 2020 Category: Reproduction Medicine Source Type: research

Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features
ConclusionWnt and MAPK pathways have a key role in the successful derivation and pluripotency features of mESC from single precompaction blastomeres. Modulation of these pathways results in mESC lines with various degrees of na ïve-like and primed-like pluripotency features. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 12, 2020 Category: Reproduction Medicine Source Type: research

‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
ConclusionImported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 12, 2020 Category: Reproduction Medicine Source Type: research

Altered evolution: are reproductive endocrinology and infertility specialists ready for the genetically engineered future?
AbstractScience, propelled forward by noble aspirations and, at times, human hubris, has the capacity to affect lives and alter the world in unanticipated ways. Even seemingly minor discoveries have repeatedly proven to have far reaching implications that experts within their respective fields could not have predicted. Nuclear technology is both a source of energy and a potential means of annihilation. The internet has both seamlessly connected the world but has also opened society to the misuse and manipulation of information. Both exemplify how new technologies have the potential for positive and negative outcomes that o...
Source: Journal of Assisted Reproduction and Genetics - October 12, 2020 Category: Reproduction Medicine Source Type: research

Successful in vitro fertilization in women with Fontan physiology
ConclusionsA multidisciplinary team-based approach can result in successful oocyte retrieval and IVF in women with complex congenital heart disease and Fontan physiology. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 10, 2020 Category: Reproduction Medicine Source Type: research

Partial-AZFc deletions in Chilean men with primary spermatogenic impairment: gene dosage and Y-chromosome haplogroups
ConclusionPartial-AZFc deletions in a Chilean admixed population are associated with secretory azo/oligozoospermia and might have a role in the development of hypospermatogenesis. Low represented haplogroups, Y-hg M and Y-hg H, show an association with the occurrence of spermatogenic failure and gr/gr deletions respectively; however, additional studies are required. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 9, 2020 Category: Reproduction Medicine Source Type: research

External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology
Conclusion(s)Although generalized linear models may allow identification of endometriosis, we did not obtain perfect classification with the selected gene candidates. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 9, 2020 Category: Reproduction Medicine Source Type: research

COVID-19 risk assessment and safety management operational guidelines for IVF center reopening
ConclusionsAs an extraordinary and uncertain event, the SARS-CoV-2 pandemic helped consolidate a volunteer-based and collaborative panel of SAMeR experts who developed the COVID-19 Risk Assessment and Safety Management Operational Guidelines as a new and readily available tool for physicians, patients, and gamete banks care. Their implementation has provided specific guidelines to minimize risk for professionals in ART clinics, as well as guaranteeing patient safety. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 6, 2020 Category: Reproduction Medicine Source Type: research

GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium  – potential biomarkers in the detection of endometriosis – a pilot study
AbstractPurposeEndometriosis (EM) is a common gynecological disease affecting 10 –15% of women of reproductive age. However, molecular mechanisms and pathogenesis are still not completely understood. Furthermore, due to the absence of a reliable clinical biomarker, the only viable method for the often-delayed definitive diagnosis is laparoscopic surgery. Our objective was to a nalyze molecular differences of selected endometrial proteins and genes of women suffering from different stages of EM compared with healthy women to evaluate potential clinical biomarkers.MethodsWe analyzed eutopic endometrial tissue samples f...
Source: Journal of Assisted Reproduction and Genetics - October 6, 2020 Category: Reproduction Medicine Source Type: research

All Models Are Wrong, but Some Are Useful
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 6, 2020 Category: Reproduction Medicine Source Type: research

Follicular fluid anti-M üllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center
AbstractPurposeTo enhance the understanding of the clinical significance of anti-M üllerian hormone (AMH) in follicular fluid, we aimed to determine the variability of AMH concentrations in follicular fluid within and across IVF cycles and whether high follicular fluid AMH concentrations are associated with improved clinical IVF outcomes.MethodsThis was a retrospective cohort study of companion follicular fluid and serum samples from 162 women enrolled in the Environment and Reproductive Health (EARTH) Study between 2010 and 2016. AMH concentrations were quantified using a sandwich enzyme-linked immunosorbent assay. S...
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research

Can frozen-thawed human ovary withstand refreezing-rethawing in the form of cortical strips?
AbstractPurposeThe aim of this study was to elucidate whether ovarian tissue is able to withstand a double freezing-thawing procedure.MethodsHuman ovarian cortical biopsies from 4 thawed whole ovaries were divided into 4 experimental subgroups: (a) frozen-thawed non-grafted group, (b) frozen-thawed xenografted group, (c) refrozen-rethawed non-grafted group, and (d) refrozen-rethawed xenografted group. Xenografting was performed using 8 severe combined immunodeficient mice for a total duration of 21  days. The following analyses were conducted: classic hematoxylin and eosin staining, Ki67 immunolabeling, transmission e...
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research

Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review
ConclusionThis is the first summary of evidence on CE pathophysiology and its relationship with infertility. Understanding the CE pathophysiology could improve our knowledge in embryo transfer success. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munn é et al.
AbstractA recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage ...
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research

What artificial intelligence may, or may not, contribute to human ARTs
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research

Molecular basis of reproductive senescence: insights from model organisms
ConclusionsStudies of reproductive aging in model organisms not only have revealed the detrimental cellular changes that occur with age but also are helping identify major regulator proteins controlling them. Here, we discuss what we have learned from model organisms with respect to the molecular mechanisms that maintain both genome integrity and oocyte quality. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 30, 2020 Category: Reproduction Medicine Source Type: research

Formative development of a fertility decision aid for transgender adolescents and young adults: a multidisciplinary Delphi consensus study
ConclusionA multidisciplinary panel of experts achieved agreement around content areas and learning objectives to incorporate into a decision aid about fertility preservation for TNB AYA. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 29, 2020 Category: Reproduction Medicine Source Type: research

Defining critical factors in multi-country studies of assisted reproductive technologies (ART): data from the US and UK health systems
We describe and compare the demographic factors between the USA and the UK related to ART use and discuss implications for research. The USA and the UK share some common elements of ART practice and in how data are collected regarding long-term outcomes. However, the monitoring of ART in these two countries each brings strengths that complement each other ’s limitations. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 29, 2020 Category: Reproduction Medicine Source Type: research

AI in the treatment of fertility: key considerations
AbstractArtificial intelligence (AI) has been proposed as a potential tool to help address many of the existing problems related with empirical or subjective assessments of clinical and embryological decision points during the treatment of infertility. AI technologies are reviewed and potential areas of implementation of algorithms are discussed, highlighting the importance of following a proper path for the development and validation of algorithms, including regulatory requirements, and the need for ecosystems containing enough quality data to generate it. As evidenced by the consensus of a group of experts in fertility i...
Source: Journal of Assisted Reproduction and Genetics - September 28, 2020 Category: Reproduction Medicine Source Type: research

A matched propensity score study of embryo morphokinetics following gonadotropin-releasing hormone agonist versus human chorionic gonadotropin trigger
AbstractPurposeTo compare morphokinetic parameters and quality of embryos derived from GnRH antagonist ICSI cycles triggered either with GnRH agonist or standard hCG between matched groups of patients.MethodsMorphokinetic parameters of embryos derived from matched first GnRH antagonist ICSI cycles triggered by GnRH agonist or standard hCG between 2013 and 2016 were compared. Matching was performed for maternal age, peak estradiol levels, and number of oocytes retrieved. Outcome measures were: time to pronucleus fading (tPNf), cleavage timings (t2-t8), synchrony of the second and third cycles (S2 and S3), duration of the se...
Source: Journal of Assisted Reproduction and Genetics - September 26, 2020 Category: Reproduction Medicine Source Type: research

Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure
ConclusionsPGT-A may be beneficial for patients with moderate recurrent implantation failure but not for severe cases. At its current level of development, ERA does not appear to be clinically useful for patients with RIF. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 23, 2020 Category: Reproduction Medicine Source Type: research

SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
ConclusionTheoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 20, 2020 Category: Reproduction Medicine Source Type: research

Male preconception antioxidant supplementation may lower autism risk: a call for studies
AbstractCurrent research indicates that a sizable number of autism spectrum disorder (ASD) cases arise from de novo mutations (DNMs) occurring within the paternal germline, usually in an age-dependent manner. Andrologists have reported that somatic cells and gametes share the same pathologies that generate these DNMs —specifically, DNA hypomethylation caused by oxidative nucleoside base damage. Because many ASD researchers seek to identify genetic risk factors, teams are developing methods of assessing aberrant DNA patterns, such as parental gonadal mosaicism. Several studies propose antioxidant supplementatio n as a...
Source: Journal of Assisted Reproduction and Genetics - September 18, 2020 Category: Reproduction Medicine Source Type: research

Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility
ConclusionsOur study not only defines a novel mutation ofTUBB8 causing the early cleavage arrest of embryos, but also provides an important basis for treating such female infertility in the future. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 17, 2020 Category: Reproduction Medicine Source Type: research

COH outcomes in breast cancer patients for fertility preservation: a comparison with the expected response by age
ConclusionThe results obtained do not support the notion of a negative impact of the BRCA mutation on the ovarian response of women with breast cancer. Women with breast cancer undergoing COH for fertility preservation can expect the ovarian response predicted for their age. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 17, 2020 Category: Reproduction Medicine Source Type: research

Rare genetic variants suggest dysregulation of signaling pathways in low- and high-risk patients developing severe ovarian hyperstimulation syndrome
ConclusionRare variants in OHSS cases with two distinct risk profiles enrich the same signaling pathways linked to VEGF and endothelial function. Clarification of the mechanism as well as potentially defining genetic predisposition of the high vascular permeability is important for future targeted treatment and prevention of OHSS; the potential roles of ILK signaling and the axonal guidance signaling need to be validated by functional studies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 17, 2020 Category: Reproduction Medicine Source Type: research

Navigating assisted reproduction treatment in the time of COVID-19: concerns and considerations
This article highlights matters of bioethical nature to be considered in the ART world at the time of COVID-19 while presenting an all-inclusive critique of the current status. When pursuing pregnancy through IVF treatment during the pandemic, distancing and caution have the lead role in an effort to defend the health of the intended parents and future children. To pr omote patient autonomy along with our ethical, moral, and legal duty towards our patients, emphasis should be given on ascertaining shared decision-making, and ensuring that an appropriate all-inclusive informed consent is signed prior to initiating any IVF t...
Source: Journal of Assisted Reproduction and Genetics - September 15, 2020 Category: Reproduction Medicine Source Type: research

Mitochondrial metabolic substrate utilization in granulosa cells reflects body mass index and total follicle stimulating hormone dosage in in vitro fertilization patients
ConclusionsGranulosa cell utilization of substrates feeding into the citric acid cycle changed with total FSH dosage and BMI. Fertilization rate, 8-cell embryo quality, and blastocyst formation also associated with different energy substrate usage. Mitochondrial substrate utilization by granulosa cells from individual follicles could be further developed into a useful diagnostic tool. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 14, 2020 Category: Reproduction Medicine Source Type: research

Impact on using cryopreservation of testicular or epididymal sperm upon intracytoplasmic sperm injection outcome in men with obstructive azoospermia: a systematic review and meta-analysis
ConclusionsIn men with OA, there was a statistical lower clinical pregnancy rate (CPR) by using frozen epididymal sperm compared with fresh epididymal sperm, but showing no difference on fertilization rate (FR). Additionally, FR and CPR were not affected by whether the retrieved testicular sperm was frozen or fresh. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 14, 2020 Category: Reproduction Medicine Source Type: research

Aging attenuates the ovarian circadian rhythm
AbstractObjectiveTo study the effect of aging on ovarian circadian rhythm.DesignHuman and animal study.SettingUniversity hospital and research laboratory.Patients/animalsHuman granulosa cells were obtained by follicular aspiration from women undergoing in vitro fertilization (IVF), and ovarian and liver tissues were obtained from female C57BL/6 mice.Intervention(s)None.Main outcome measure(s)Expression of circadian genes in young and older human granulosa cells and circadian rhythm in ovaries and livers of young and older mice.Result(s)All examined circadian clock genes in human granulosa cells showed a downward trend in e...
Source: Journal of Assisted Reproduction and Genetics - September 13, 2020 Category: Reproduction Medicine Source Type: research

Climate change and the morphing of human ARTs
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 9, 2020 Category: Reproduction Medicine Source Type: research

When pregnancy is a research risk
AbstractA published study reported by Munn é using uterine lavage to retrieve in vivo blastocysts for preimplantation genetic testing has been the subject of several technical and ethical critiques. None of these critiques has been based on a review of the study’s IRB-approved informed consent. This commentary seeks to do that, examining the Munné (and related Nadal) consent forms for their conformity to existing requirements for a full and informed consent. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 9, 2020 Category: Reproduction Medicine Source Type: research

The unknown human trophectoderm: implication for biopsy at the blastocyst stage
AbstractTrophectoderm biopsy is increasingly performed for pre-implantation genetic testing of aneuploidies and considered a safe procedure on short-term clinical outcome, without strong assessment of long-term consequences. Poor biological information on human trophectoderm is available due to ethical restrictions. Therefore, most studies have been conducted in vitro (choriocarcinoma cell lines, embryonic and pluripotent stem cells) and on murine models that nevertheless poorly reflect the human counterpart. Polarization, compaction, and blastomere differentiation (e.g., the basis to ascertain trophectoderm origin) are po...
Source: Journal of Assisted Reproduction and Genetics - September 5, 2020 Category: Reproduction Medicine Source Type: research

Evidence of metabolic activity during low-temperature ovarian tissue preservation in different media
ConclusionOur results indicate marked metabolic activity in ovarian tissue at 4  °C and suggest that cells use internal sources of energy, which may influence transplantation outcomes. This highlights the importance of better understanding whole tissue dynamics to develop a standard protocol for ovarian tissue transportation.Graphical abstract (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 3, 2020 Category: Reproduction Medicine Source Type: research

Genome-wide association study identifies candidate markers related to lincRNAs associated with male infertility in the Greek population
Discussion and conclusionlncRNAs are involved in spermatogenesis through their interaction with miRNAs. Thus, their study is very important, and it may contribute to the understanding of the molecular mechanisms underlying male infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - September 2, 2020 Category: Reproduction Medicine Source Type: research