Are ovarian response and pregnancy rates similar in selected FMR1 premutated and mutated patients undergoing preimplantation genetic testing?
ConclusionIn spite of lower ovarian reserve and thanks to an increased total dose of FSH,FMR1 premutated selected patients seem to have similar ovarian response as fully mutated patients. Neither the number of CGG repeats inFMR1 gene norFMR1 mutation status was good predictors of the number of retrieved oocytes. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 2, 2020 Category: Reproduction Medicine Source Type: research

Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis
ConclusionsA multi-omics insight into molecular patterns underlying endometriosis could contribute towards identification of endometrial pathological mechanisms that impact fertility capacities of women with endometriosis. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 30, 2020 Category: Reproduction Medicine Source Type: research

Literacy assessment of preimplantation genetic patient education materials exceed national reading levels
ConclusionsFor most American adults, materials about IVF+PGT-M are not readable, understandable, or clear. The Joint Commission requires patient education materials be written at or below 5th grade reading level and the CDC recommends a 90% minimum score for comprehensibility. No evaluated material met these guidelines. Patient education materials that exceed average American literacy skills may perpetuate disparities in the utilization of IVF+PGT-M. Materials that communicate this complicated subject at an understandable level are needed. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 29, 2020 Category: Reproduction Medicine Source Type: research

Is the probability of pregnancy after ovarian stimulation for IVF associated with serum estradiol levels on the day of triggering final oocyte maturation with hCG? A systematic review and meta-analysis
ConclusionCurrently, there is insufficient evidence to support or deny the presence of an association between the probability of pregnancy and serum Ε2 levels on the day of triggering final oocyte maturation with hCG in women undergoing ovarian stimulation for IVF. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 29, 2020 Category: Reproduction Medicine Source Type: research

Social media in ART —#power or #peril?
AbstractThe impact of social media on the practice of ART is rapidly increasing, heralding great promise, but also significant risks. Since social media are likely here to stay, providers should familiarize themselves with this rapidly emerging phenomenon and decide how to best use it for their practice. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 28, 2020 Category: Reproduction Medicine Source Type: research

A recommendation for IVF lab practice in light of the current COVID-19 pandemic
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 28, 2020 Category: Reproduction Medicine Source Type: research

The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users
ConclusionThis survey broadens understanding of the specialized needs of women, couples, and minority groups undergoing PGT and underscores the relevance of counseling services for PGT users. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 27, 2020 Category: Reproduction Medicine Source Type: research

Infertility and assisted reproductive technology outcomes in Afro-Caribbean women
ConclusionAfro-Caribbean women receiving infertility care in the Caribbean may have better ART outcomes compared to African-American women in the United States (US). (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 27, 2020 Category: Reproduction Medicine Source Type: research

IUI and uterine lavage of in vivo –produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?
AbstractA recent study by Munn é et al. portrayed a protocol to retrieve in vivo produced blastocysts after IUI and uterine lavage for preimplantation genetic testing (PGT) purposes. The authors claimed this protocol might represent a reasonable future perspective for patients who do not want to undergo IVF, but still want to be informed about their embryos’ genetic/chromosomal defects. Although the intent of making PGT available also to patients who cannot or do not need to undergo IVF is respectable, the value of this study is undermined by severe technical and ethical issues. Munné and colleagues&rsq...
Source: Journal of Assisted Reproduction and Genetics - May 26, 2020 Category: Reproduction Medicine Source Type: research

Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.MethodsA total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromoso...
Source: Journal of Assisted Reproduction and Genetics - May 25, 2020 Category: Reproduction Medicine Source Type: research

Commentary on: A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2020 Category: Reproduction Medicine Source Type: research

In response to the article titled Thoughts on the Ethics of Gestational Surrogacy: Perspectives from Religions, Western Liberalism, and Comparisons with Adoption Issue Date: January 2020
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2020 Category: Reproduction Medicine Source Type: research

Does omitting teratospermia as a selection criterion for ICSI change pregnancy rates?
ConclusionThis study concurs with the recent data suggesting that employing ICSI solely for teratospermia is unnecessary. This may allow clinics to decrease ICSI rates without sacrificing success rates, leading to lower cost and risk associated with treatment. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2020 Category: Reproduction Medicine Source Type: research

An update on stem cell therapy for Asherman syndrome
AbstractThe current treatment for Asherman syndrome is limited and not very effective. The aim of this review is to summarize the most recent evidence for stem cells in the treatment of Asherman syndrome. The advent of stem cell therapy has propagated experimentation on mice and humans as a novel treatment. The consensus is that the regenerative capacity of stem cells has demonstrated improved outcomes in terms of fertility and fibrosis in both mice and humans with Asherman syndrome. Stem cells have effects on tissue repair by homing to the injured site, recruiting other cells by secreting chemokines, modulating the immune...
Source: Journal of Assisted Reproduction and Genetics - May 22, 2020 Category: Reproduction Medicine Source Type: research

Next-generation sequencing analysis of each blastomere in good-quality embryos: insights into the origins and mechanisms of embryonic aneuploidy in cleavage-stage embryos
ConclusionsIn good-quality embryos, there was a high rate and diverse array of chromosomal abnormalities. Morphological evaluation does not appear to assist in the reduction in meiotic errors from parental origins. Mitotic errors were common, and nondisjunction was found to be the main mechanism causing malsegregation during the cleavage divisions. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 22, 2020 Category: Reproduction Medicine Source Type: research

Correction to: A prospective randomized trial comparing corifollitropin- α late-start (day 4) versus standard administration (day 2) in expected poor, normal, and high responders undergoing controlled ovarian stimulation for IVF
The original article unfortunately has a missing acknowledgement. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 22, 2020 Category: Reproduction Medicine Source Type: research

Reproductive outcomes with donor sperm in couples with severe male-factor infertility after intracytoplasmic sperm injection failures
We report the following outcomes: (1) live birth rates in AID and IVF-D treatment for couples with severe male infertility factors and prior ICSI failures; (2) paternal impact on embryo development of the same oocyte cohort; (3) prognostic factors in obtaining a live birth with donor semen.ResultsOf 92 women with failed ICSI cycles (26 with multiple attempts), 45 couples underwent AID treatment. Live birth rate per cycle of AID was 18.9%. Fifty-three patients underwent IVF-D including 6 couples who previously did not conceive with AID. Embryological outcomes including fertilization, viable cleavage embryos, and blastocyst ...
Source: Journal of Assisted Reproduction and Genetics - May 21, 2020 Category: Reproduction Medicine Source Type: research

Comparison of indications and results of prenatal invasive diagnostic tests before and after the implementation of the use of cell-free fetal DNA: a tertiary referral center experience
In this study, we aimed to compare the changes in the number, yield, and the percentage of karyotyping indications of the invasive prenatal diagnostic tests between the periods before and after cell-free fetal DNA was introduced to clinical use.MethodThe number of invasive prenatal diagnostic procedures such as amniocentesis and chorionic villus sampling, indication percentages and karyotype results in the periods before (January 1, 2009 –December 31, 2010), (n = 1412) and after (January 1, 2016–December 31, 2017), and (n = 593) the introduction of cell-free fetal DNA was retrospecti...
Source: Journal of Assisted Reproduction and Genetics - May 21, 2020 Category: Reproduction Medicine Source Type: research

Apoptosis triggers the release of microRNA miR-294 in spent culture media of blastocysts
AbstractPurposeTo study whether members of the miR-290-295 cluster in spent culture medium (SCM) of embryos are correlated with morphokinetics and apoptosis.MethodsCryopreserved 1-cell stage mouse embryos were cultured to the blastocyst stage, development was monitored by time-lapse, 59 SCM were collected, and miR-291a and miR-294 were detected with polymerase chain reaction (PCR). Blastocysts were immuno-stained for sexing (H2AK119ub) and for apoptosis (TUNEL). Each embryo and SCM were individually processed. Correlations were run between the miRNAs and developmental events (t2, t3, t4, t5, t8, tSB, tB, ECC2, ECC3, s2, s3...
Source: Journal of Assisted Reproduction and Genetics - May 21, 2020 Category: Reproduction Medicine Source Type: research

Is guided, targeted information about the risks of twin pregnancy able to increase the acceptance of single embryo transfer among IVF couples? A prospective study
AbstractObjectiveTo assess whether receiving information about twin pregnancy in the form of oral presentation given by a physician could affect the acceptance of single embryo transfer (SET) by couples undergoing IVF.Study designProspective interventional study.SettingUniversity hospital IVF unit.PatientsOne hundred and forty patients (70 couples) undergoing IVF.InterventionsA questionnaire to measure patients ’ emotions about twin pregnancy was administered to IVF patients just before and immediately after attending a slide presentation in which the risks of twin pregnancy were explained. Patients scored (1 to 6) t...
Source: Journal of Assisted Reproduction and Genetics - May 21, 2020 Category: Reproduction Medicine Source Type: research

KIR and HLA-C genes in male infertility
ConclusionFertile men differ in profile ofKIR genes andKIR-HLA-C combinations from men participating in IVF. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

Is intracytoplasmic sperm (ICSI) better than traditional in vitro fertilization (IVF): confirmation of higher blastocyst rates per oocyte using a split insemination design
AbstractPurposeTo explore the effects of traditional vs. intracytoplasmic sperm injection (ICSI) insemination method on the outcome of high-quality blastocyst development in a split sibling oocyte cohort.MethodsIn this retrospective cohort study, we analyzed 62 ICSI/IVF split cycles. Sibling oocytes were randomly assigned to ICSI or IVF insemination. Two hundred thirty-four ICSI-only cycles and 152 IVF-only cycles were also analyzed for comparison. Blastocysts were graded by Gardner ’s embryo grading and were considered a high-quality blastocyst if 3BB or better (Gardner1999).ResultsIn the ICSI/IVF split group, (1) I...
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

Combinational approach of retrospective clinical evidence and transcriptomics highlight AMH superiority to FSH, as successful ICSI outcome predictor
ConclusionOverall, this study offers new insight on AMH effects upon cumulus cells and new aspects on how AMH might promote oocyte integrity and embryo viability at a biochemical level as well as add to the current body of evidence supporting AMH clinical potential as a more sensitive marker ofIVF outcomes in comparison with FSH, regarding numbers of oocytes received and high-quality day 2 and day 3 embryos. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

Hypothermic machine perfusion after static cold storage improves ovarian function in rat ovarian tissue transplantation
This study was performed to investigate the effect of hypothermic machine perfusion (HMP) after cold storage (CS) on ovarian transplantation.MethodsRats aged 8 –10 weeks were used as the donors and recipients for allotransplantation. Eighteen donor rats were divided into three groups: the fresh control (n = 6), cold storage (CS;n = 6), and hypothermic machine perfusion (HMP;n = 6) groups. The preservation solution contained Dulbecco’s modified Eagle’s medium/Ham’s F-12 (1:1,v/v), 10% fetal bovine serum, 10  μg/ml insulin, 10 μg/ml transf...
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

Morphokinetic analysis of cleavage stage embryos and assessment of specific gene expression in cumulus cells independently predict human embryo development to expanded blastocyst: a preliminary study
AbstractTo assess whether morphokinetic features at the cleavage stage together with specific gene expression in cumulus cells (CCs) may be used to predict whether human embryos are able to achieve the expanded blastocyst stage on day 5. Eighty-one embryos were cultured using the Geri plus ® time-lapse system. Twenty-seven embryos progressing to the expanded blastocyst stage (BL group) were compared with thirty-five embryos showing developmental arrest (AR group) and nineteen reaching the stage of early or not fully expanded blastocyst (nBL group). The analyzed morphokinetic variable s were pronuclear appearance (tPNa)...
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

Oocyte retrieval outcomes among adolescent transgender males
AbstractPurposeTo compare fertility preservation (FP) outcomes among adolescent transgender males with those of cisgender females.MethodsThis retrospective cohort study included nine adolescent transgender males and 39 adolescent cisgender females who underwent FP between January 2017 –April 2019 and September 2013–April 2019, respectively. The transgender males were referred before initiating testosterone, and the cisgender females were referred due to cancer diagnosis before starting anticancer treatment. Statistical analyses compared assisted reproductive technology (ART) data and FP outcomes between two gro...
Source: Journal of Assisted Reproduction and Genetics - May 20, 2020 Category: Reproduction Medicine Source Type: research

PTEN and FOXO3 expression in the prenatal and postnatal human ovary
ConclusionOur results seem to indicate that two subpopulations of primordial follicles, i.e. nuclear FOXO3-expressing and no FOXO3-expressing primordial follicles are found in the postnatal human ovary. This scenario suggests that FOXO3 could be acting as in the mouse model, preventing primordial follicle activation. However, the strategy would not be an “all or nothing” system as in mouse ovary but rather a selected subpopulation of primordial follicles preserved to ensure long-term fertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 19, 2020 Category: Reproduction Medicine Source Type: research

In-house genetic counseling increases the detection of abnormal karyotypes —a 26-year experience in prenatal diagnosis in a single tertiary referral hospital in Poland
AbstractPurposeTo evaluate the trends in prenatal diagnosis over 26 years in a tertiary referral hospital.MethodsA retrospective analysis of invasive prenatal procedures performed between 1991 and 2016. Maternal characteristics, indications for invasive diagnosis, and percentage of abnormal karyotypes were compared between periods according to guidelines implemented nationally and locally.ResultsA total of 14,302 invasive prenatal procedures were performed. The proportion of invasive procedures performed for advanced maternal age, abnormal karyotype in a previous pregnancy, and maternal anxiety decreased from 71.1%, 17.8%,...
Source: Journal of Assisted Reproduction and Genetics - May 19, 2020 Category: Reproduction Medicine Source Type: research

Buffering reproductive science in the era of COVID-19
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 18, 2020 Category: Reproduction Medicine Source Type: research

Examination of fetal growth trajectories following infertility treatment
ConclusionThese findings contribute to the very limited literature on fetal growth trajectories following infertility treatment and suggest no significant differences in fetal growth for ovulation induction with IUI, fresh ET, FET, and spontaneous conception following infertility. It is possible there were no differences in growth trajectories between these conception methods because the majority of children born following infertility are of normal birth weight. While results are reassuring, further research with larger populations is warranted. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 18, 2020 Category: Reproduction Medicine Source Type: research

Likelihood of achieving a 50%, 60%, or 70% estimated live birth rate threshold with 1 or 2  cycles of planned oocyte cryopreservation
AbstractPurposeTo characterize the likelihood of cryopreserving enough oocytes for 50%, 60%, or 70% estimated live birth rate (eLBR) with 1 –2 planned oocyte cryopreservation (Pl-OC) cycles.MethodsWe performed a retrospective cohort study utilizing all patients completing ≥ 1 Pl-OC cycle from 2016 to 2018 at a large single-center OC program. Subjects were categorized by age at retrieval and number of cycles. We extrapolated age-based oocyte thresholds for 50%, 60%, or 70% eLBR from previously published data. We calculated the proportion of subjects overall, and f or each age group, whose number of frozen oo...
Source: Journal of Assisted Reproduction and Genetics - May 16, 2020 Category: Reproduction Medicine Source Type: research

Motives and considerations regarding PGT in couples carrying a structural chromosomal abnormality: a qualitative exploration
ConclusionThis study shows that couples carrying a structural chromosomal abnormality consider PGT and spontaneous conception with PND as relevant reproductive options. They are looking for the option that is in their opinion the fastest way to establish a successful pregnancy. Information on the perceived pros and cons of PGT or spontaneous conception in these couples can help to optimize counselling and psychological support during the decision-making process. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 16, 2020 Category: Reproduction Medicine Source Type: research

Detection of IL-6, IL-10, and TNF- α level in human single-blastocyst conditioned medium using ultrasensitive Single Molecule Array platform and its relationship with embryo quality and implantation: a pilot study
AbstractPurposeThe purpose was to investigate the association between embryonic development or implantation and the content of interleukin-6 and 10 (IL-6, IL-10) and tumor necrosis factor- α (TNF-α) in single-blastocyst conditioned medium (SBCM).MethodsThirty-eight SBCM samples (SBCMs) were collected from blastocysts with different morphological scores. IL-6, IL-10, and TNF- α concentration in 38 SBCMs was detected by Single Molecule Array and compared according to the blastocyst quality: top-quality (TQ) and non-top quality (NTQ), or blastulation time: day 5 (D5) and day 6 (D6). In another experiment, 61...
Source: Journal of Assisted Reproduction and Genetics - May 15, 2020 Category: Reproduction Medicine Source Type: research

Chromosome analysis of blastocysts derived from single pronuclear zygotes by array CGH and clinical outcomes by the transfer of single pronuclear zygotes
ConclusionWithin the limits of the small sample size, our results suggest that the aneuploidy and delivery rates of the blastocysts derived from 1PN zygotes are the same as those derived from 2PN zygotes. Blastocysts derived from 1PN zygotes may be used clinically and could increase the chance of pregnancy. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 15, 2020 Category: Reproduction Medicine Source Type: research

Access to infertility care in a low-resource setting: bridging the gap through resident and fellow education in a New York City public hospital
ConclusionBy utilizing the ambition and construct of the OB/GYN programs, we greatly improve care for an otherwise underserved patient population by offering an efficient and optimal infertility workup and treatment in a population that would otherwise be without care. We utilize the framework of graduate medical education to provide autonomy, experience, and mentorship to both residents and fellows in our programs in an effort to provide a solution to combating inequity in infertility care. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 14, 2020 Category: Reproduction Medicine Source Type: research

Squaring the circle of recurrent pregnancy loss (RPL)
AbstractThe recent publication of a study into the contribution of embryo chromosomal abnormalities in recurrent pregnancy loss (RPL) affords the opportunity to revisit the hypothesis that women with an aneuploid pregnancy loss have a better chance of a successful pregnancy next time than women with a chromosomally normal loss. A previous miscarriage with an abnormal karyotype (unrelated to a parental chromosome rearrangement) should not be viewed as a marker of an increased likelihood of aneuploidy in a subsequent pregnancy; it is (counterintuitively) likely to be indicative of a reduced risk of clinical miscarriage (with...
Source: Journal of Assisted Reproduction and Genetics - May 14, 2020 Category: Reproduction Medicine Source Type: research

Impaired reproductive function and fertility preservation in a woman with a dyskeratosis congenita
ConclusionsWe demonstrate for the first time the direct detrimental impacts of short telomeres on female fertility. We further demonstrate positive effects of hormone treatments for people with telomere disorders. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 13, 2020 Category: Reproduction Medicine Source Type: research

Sperm count affects cumulative birth rate of assisted reproduction cycles in relation to ovarian response
ConclusionsThe study highlights the importance of sperm quality for the efficacy of assisted reproduction treatments. This influence may remain relatively cryptic in association with normal or high ovarian response, but emerge decisively in cases of reduced ovarian response, suggesting a relationship between ovarian response and oocyte ability to compensate for paternal-derived deficiencies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 13, 2020 Category: Reproduction Medicine Source Type: research

Interaction of thrombophilic SNPs in patients with unexplained infertility —multifactor dimensionality reduction (MDR) model analysis
ConclusionTheMTHFR C677T polymorphism was significantly associated with UI, with minor allele T being more frequent. Additionally, there was a significantly increased presence ofMTHFR C677T withFVL mutation in these patients. Therefore,MTHFR and its interaction withFVL should be recognized as contributing factors in the pathogenesis of infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 13, 2020 Category: Reproduction Medicine Source Type: research

Small supernumerary marker chromosomes (sSMC) and male infertility: characterization of five new cases, review of the literature, and perspectives
ConclusionThrough this study, we emphasize the necessity of a proper combination of high-throughput techniques with conventional cytogenetic and FISH methods. This could provide a personalized diagnostic and accurate results for the patients suffering from infertility or RPL. We also highlight FISH analyses, which are essential tools for detecting sSMC in infertile patients. In fact, despite its entire composition of heterochromatin, sSMC can have effects on spermatogenesis by producing mechanical perturbations during meiosis and increasing meiotic nondisjunction rate. This would contribute to understand the exact chromoso...
Source: Journal of Assisted Reproduction and Genetics - May 12, 2020 Category: Reproduction Medicine Source Type: research

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
ConclusionsThese results suggest that mouseNlrp9b, as a maternal effect gene, could contribute to mouse preimplantation embryo development. It remains to investigate whether NLRP9 have a crucial role in human preimplantation embryo and infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 12, 2020 Category: Reproduction Medicine Source Type: research

Efficacy of MLPA for detection of Y-chromosome microdeletions in infertile Brazilian patients
ConclusionOur results demonstrate that MLPA technique is valuable in the investigation of microdeletions and microduplications. Besides deletions, duplications can cause instability of chromosome genes, possibly leading to infertility. Both studied techniques provide an advantageous diagnostic strategy, thus enabling a better genetic counseling. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 12, 2020 Category: Reproduction Medicine Source Type: research

Ovarian tissue cryopreservation as standard of care: what does this mean for pediatric populations?
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 11, 2020 Category: Reproduction Medicine Source Type: research

Correction to: How good are we at modeling implantation?
The original article unfortunately contained a mistake. The name of the author should be Lusine Aghajanova instead of Aghajanova Lusine. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 8, 2020 Category: Reproduction Medicine Source Type: research

Infertility influencers: an analysis of information and influence in the fertility webspace
ConclusionAs patients increasingly utilize social media to obtain and engage with health information, it is critical to understand the fertility-related SM landscape. This understanding may help to successfully enhance relationships with patients and ensure dissemination of accurate information. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 7, 2020 Category: Reproduction Medicine Source Type: research

An explanation of the mechanisms underlying fragile X-associated premature ovarian insufficiency
The objective of this paper was to formulate a theory to explain the Mechanism for FXPOI.Recent research on fragile X syndrome and FXTAS has led to sophisticated theories about the mechanisms underlying these diseases. It has been proposed that similar mechanisms underlie FXPOI. Utilizing recent research on FXTAS, but a more detailed application of ovarian physiology, we present a more ovarian specific theory as to the primary mechanism explaining the development of FXPOI.The FXPOI phenotype may best be viewed as derivative of the observation that fragile X PM carriers experience menopause an average of 5  years earli...
Source: Journal of Assisted Reproduction and Genetics - May 6, 2020 Category: Reproduction Medicine Source Type: research

Blastocyst mitochondrial DNA (mtDNA) is not affected by oocyte vitrification: a sibling oocyte study
AbstractPurposeTo evaluate whether mtDNA content at the blastocyst stage differs between embryos derived from fresh or vitrified sibling oocytes.Material and methodsA retrospective analysis was performed between March 2017 and September 2018, including 504 blastocysts from 94 couples undergoing preimplantation genetic testing for aneuploidies (PGT-A), using fresh oocytes together with previously vitrified oocytes. Trophectoderm biopsies were performed and subjected to next generation sequencing.ResultsOn average, 1.8  ± 1.0 oocyte vitrification cycles were performed per patient. Between fresh and vitri...
Source: Journal of Assisted Reproduction and Genetics - May 6, 2020 Category: Reproduction Medicine Source Type: research

Long-term imatinib diminishes ovarian reserve and impacts embryo quality
AbstractPurposeTyrosine kinase inhibitors (TKIs) such as imatinib are commonly used chemotherapeutics, but the effects of long-term treatments on reproductive outlook for cancer survivors are unknown. The purpose of this study was to examine the effects of long-term imatinib treatments on follicle development and embryo quality. Since prospective studies are not possible in healthy humans, we have incorporated a commonly used mouse model.MethodsAdult female mice were treated with daily IP injections of imatinib for 4 –6 weeks. Liquid chromatography-mass spectrometry was used to measure imatinib in serum and ovar...
Source: Journal of Assisted Reproduction and Genetics - May 6, 2020 Category: Reproduction Medicine Source Type: research

Clinical and genetic analysis of an isolated follicle-stimulating hormone deficiency female patient
ConclusionThe mutation Arg97X could disturb structural stability of the resulting FSH protein consisting of FSH α and mutant FSHβ subunit, which may lead to FSH deficiency. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 5, 2020 Category: Reproduction Medicine Source Type: research

Misreporting published data is not the way forward for a constructive scientific debate
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 4, 2020 Category: Reproduction Medicine Source Type: research