Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database
AbstractPurposeTo describe the association between contemporary total motile count (TMC), a measure of male factor infertility, and historic intergenerational family size.MethodsThis is a retrospective, population-based, cohort study of men who underwent semen analysis for infertility workup at University of Utah, with at least a single measure of TMC, who were linked to extensive genealogical data. Two thousand one hundred eighty-two pedigree branches of men with a measure of TMC within the UPDB were identified. We identified the average number of generations and offspring within each generation. Conditional logistic regr...
Source: Journal of Assisted Reproduction and Genetics - February 24, 2021 Category: Reproduction Medicine Source Type: research

Live birth in a complete zona-free patient: a case report
ConclusionLive birth can be achieved for patients with zona production deficiency. Adjustment in ovarian stimulation and subsequent embryo culture strategies may have potentially contributed to the success of the 3rd cycle. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 24, 2021 Category: Reproduction Medicine Source Type: research

Early rescue oocyte activation for activation-impaired oocytes with no second polar body extrusion after intracytoplasmic sperm injection
AbstractPurposeWhen rescue artificial oocyte activation (ROA) is performed on the day after intracytoplasmic sperm injection (ICSI) or later, embryonic development is poor and seldom results in live births. The efficacy of an early ROA after ICSI is unclear. Is early ROA effective in rescuing unfertilized oocytes that have not undergone second polar body extrusion several hours after ICSI?MethodsWe performed retrospective cohort study between October 2016 and September 2019, targeting 2891 oocytes in 843 cycles when ICSI was performed. We performed ROA with calcium ionophore on 395 of the 475 oocytes with no second polar e...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2021 Category: Reproduction Medicine Source Type: research

Centriolar defects, centrin 1 alterations, and FISH studies in human spermatozoa of a male partner of a couple that produces aneuploid embryos in natural and artificial fertilization
AbstractPurposeTo study the potential paternal contribution to aneuploidies in the man of a couple who obtained trisomic embryos with natural and assisted fertilization.MethodsSemen analysis, immunofluorescence for localization of tubulin and centrin 1, transmission electron microscopy (TEM), and fluorescence in situ  hybridization (FISH) analysis for chromosomes 18 and 9 were performed. Sperm of fertile men were used as controls.ResultsThe percentages of sperm motility and normal forms were decreased. The percentages of sperm with tail reduced in dimension, headless tails, coiled tails, and altered head-tail junction...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2021 Category: Reproduction Medicine Source Type: research

Improved maturation competence of ovarian tissue oocytes using a biphasic in vitro maturation system for patients with gynecological malignancy: a study on sibling oocytes
ConclusionsThe biphasic in vitro maturation system improved the competence of OTO in comparison to the standard IVM method. The study suggests that fertility preservation programs could become more efficient using IVM after capacitation culture. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2021 Category: Reproduction Medicine Source Type: research

Massaging the message: an abundance of communication pathways used and abused
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2021 Category: Reproduction Medicine Source Type: research

A novel splicing variant in DNAH8 causes asthenozoospermia
ConclusionsThis finding expands the mutational spectrum ofDNAH8, making it a potential genetic diagnostic marker for those suffering from primary male infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 20, 2021 Category: Reproduction Medicine Source Type: research

CAG repeat instability in embryonic stem cells and derivative spermatogenic cells of transgenic Huntington ’s disease monkey
ConclusionsHere, we report a novel stem cell model that replicates genome instability and CAG repeat expansion inin vitro derived HD monkey spermatogenic cells. Thein vitro spermatogenic cell model opens a new opportunity for studying TNR instability and the underlying mechanism of genetic anticipation, not only in HD but also in other TNR diseases. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 20, 2021 Category: Reproduction Medicine Source Type: research

Elective oocyte cryopreservation for age-related fertility decline
ConclusionsElective oocyte cryopreservation is one of the most controversial aspects of the world of assisted reproduction, and a lot of questions remain unanswered. However, women today do have this option which was not available in the past. Elective oocyte cryopreservation for age-related fertility decline should be incorporated in women ’s reproductive options to ensure informed decisions and reproductive autonomy. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 19, 2021 Category: Reproduction Medicine Source Type: research

Optimizing the control group for evaluating ART outcomes: can outpatient claims data yield a better control group?
ConclusionAlthough the APCD allowed identification of more women than the previously defined subfertile categorization and allowed us to remove previously unidentified infertile women from the fertile group, it is not clear that  it offered a clinically significantly improved comparison group. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 19, 2021 Category: Reproduction Medicine Source Type: research

A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility
ConclusionThis study identified a novel pathogenic variant inZP2 that produces a truncated ZP2 protein. The variant might disrupt the assembly of ZP2-ZP3 dimers, thus resulting in a thin ZP and female infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 18, 2021 Category: Reproduction Medicine Source Type: research

Liability for embryo mix-ups in fertility practices in the USA
ConclusionIt is prudent for clinics to protect themselves from embryo mix-ups, which can subsequently lead to undesirable clinical outcomes, as well as lawsuits stemming from these errors. This article emphasizes following labeling guidelines when storing embryos, employing a two-step read back method prior to ET, and offering genetic testing when a discrepancy is found in the record. In the case an embryo mix-up does occur, it is recommended to protect personal assets through business organizing procedures and consider settlement offers for policy limits. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 18, 2021 Category: Reproduction Medicine Source Type: research

Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus
ConclusionThe efficiency of the ART laboratory can be improved through professional guidelines on standardized practices and optimized embryo culture environment, assessment, selection and cryopreservation methodologies, thereby reducing the time to a healthy singleton delivery. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 18, 2021 Category: Reproduction Medicine Source Type: research

Elevated ovarian pentraxin 3 in polycystic ovary syndrome
ConclusionElevated ovarian PTX3 level supports the low-grade chronic inflammatory state in the follicles of PCOS. The existence of PCOS, disturbed pituitary gland, and ovarian hyperandrogenism might also be related to this state of low-grade chronic inflammation and could be a subject of further study. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 16, 2021 Category: Reproduction Medicine Source Type: research

Blastocyst age, expansion, trophectoderm morphology, and number cryopreserved are variables predicting clinical implantation in single blastocyst frozen embryo transfers in freeze-only-IVF
Conclusion(s)Using blastocyst age and before transfer blastocyst expansion and trophectoderm morphology scores to select blastocysts, clinical implantation rates greater than 70% could be achieved for top-scoring blastocysts. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 16, 2021 Category: Reproduction Medicine Source Type: research

Time-lapse technology improves total cumulative live birth rate and shortens time to live birth as compared to conventional incubation system in couples undergoing ICSI
ConclusionsWe found that TCLBR and TTLB were significantly improved with TLT over CI in couples undergoing ICSI for male factor. This study fuels the debate on the clinical benefit of using TLT. The use of time-related endpoints adds important information for both patients and practitioners. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 12, 2021 Category: Reproduction Medicine Source Type: research

Assessing the quality of decision-making for planned oocyte cryopreservation
AbstractPurposeThis survey study aims to examine the quality of planned oocyte cryopreservation (POC) decision-making in the domains of decision change, decision difficulty, decision regret and informed choice.MethodsOf the 224 women who completed at least one POC cycle between 2012 and 2018 at a Canadian academic IVF centre, 198 were reachable by email for anonymous survey participation.ResultsNinety-eight questionnaires were returned (response rate 49.5%). Of these, 86 fully completed questionnaires were analyzed for this study. Eighty-eight percent of respondents stated that it was a ‘good decision’ to cryop...
Source: Journal of Assisted Reproduction and Genetics - February 11, 2021 Category: Reproduction Medicine Source Type: research

Prospective analysis of progesterone exposure in programmed single thawed euploid embryo transfer cycles and outcomes
AbstractPurposeIn the era of personalized medicine and the increased use of frozen embryo transfer (FET), assay of the endometrium ’s receptivity prior to transfer has gained popularity, especially among patients. However, the optimal timing for single thawed euploid embryo transfers (STEET) in a programmed FET has yet to be determined Mackens et al. (Hum Reprod. 32(11):2234–42,2017). We sought to examine the outcomes of euploid FETs by length of progesterone (P4) exposure.MethodsProspective cohort study of programmed FETs of single euploid embryos between June 1, 2018, and December, 18, 2018, at our center. Su...
Source: Journal of Assisted Reproduction and Genetics - February 10, 2021 Category: Reproduction Medicine Source Type: research

Impact of a novel family-centered values clarification tool on adolescent sperm banking attempts at the time of a new cancer diagnosis
ConclusionAdolescent sperm banking attempt rates significantly increased after implementation of a family-centered FP values clarification tool prior to cancer treatment. Findings underscore the importance of targeting both adolescents and their parents, particularly fathers, in FP efforts. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 10, 2021 Category: Reproduction Medicine Source Type: research

Noninvasive prenatal detection of fetal sex chromosome abnormalities using the semiconductor sequencing platform (SSP) in Southern China
ConclusionOur study showed that NIPT was reliable for screening SCAs based on a large sample, and it performed better in predicting sex chromosome trisomies than monosomy X. Our study will provide an important reference for clinical genetic counseling and further processing of the results. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 10, 2021 Category: Reproduction Medicine Source Type: research

Changing perspectives on liquid nitrogen use and storage
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 10, 2021 Category: Reproduction Medicine Source Type: research

Correction to: Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age
A Correction to this paper has been published: https://doi.org/10.1007/s10815-021-02076-6 (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 10, 2021 Category: Reproduction Medicine Source Type: research

How genetics human ART style is making dreams come true: the stairway to eugenics
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 9, 2021 Category: Reproduction Medicine Source Type: research

Fertility and pregnancy outcome among women undergoing assisted reproductive technology treatment in Windhoek, Namibia
ConclusionThe outcome of this study may not give a clear indication of the prevalence of infertility among women in the entire Namibian nation due to the costs involved with ART treatment offered mainly at privately owned hospitals and/or clinics, thereby resulting in those who cannot afford treatment to be left out despite being infertile. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 8, 2021 Category: Reproduction Medicine Source Type: research

Emotional stress and reproduction: what do fertility patients believe?
ConclusionThe majority of women seeking fertility care believe emotional stress could reduce the success of fertility treatment. Furthermore, beliefs about emotional stress and reproduction significantly differ based on race/ethnicity, income, and education. Particular attention should be paid to specific groups of women who may more likely not be aware of the lack of a proven biological relationship between emotional stress and reproduction. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 6, 2021 Category: Reproduction Medicine Source Type: research

Risks of nonchromosomal birth defects, small-for-gestational age birthweight, and prematurity with in vitro fertilization: effect of number of embryos transferred and plurality at conception versus at birth
ConclusionExcess embryos transferred are associated with increased risks for nonchromosomal birth defects, reduced birthweight, and prematurity in IVF-conceived births. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 5, 2021 Category: Reproduction Medicine Source Type: research

SARS-CoV-2 persistence at subzero temperatures
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 5, 2021 Category: Reproduction Medicine Source Type: research

Genetic etiologic analysis in 74 Chinese Han women with idiopathic premature ovarian insufficiency by combined molecular genetic testing
ConclusionThis study suggested targeted NGS was an efficient etiologic test for idiopathic POI patients withoutFMR1 premutation and enriched the variant spectrum of POI-related genes. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 4, 2021 Category: Reproduction Medicine Source Type: research

Growth hormone supplementation during ovarian stimulation improves oocyte and embryo outcomes in IVF/PGT-A cycles of women who are not poor responders
ConclusionOur study uniquely investigated the use of adjuvant GH in IVF/PGT-A cycles in women without POR and without a priori suspicion for poor outcome based on their clinical parameters. Our study presents preliminary evidence that GH supplementation in these women is beneficial and is associated with an increased number of blastocysts for biopsy and greater number of euploid embryos for transfer. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 3, 2021 Category: Reproduction Medicine Source Type: research

Sonographic abnormalities in pregnancies conceived following IVF with and without preimplantation genetic testing for aneuploidy (PGT-A)
ConclusionThe use of PGT-A was not associated with a difference in risk of fetal anomaly detection on a mid-trimester anatomical survey. The results of this study highlight the importance of improved patient counseling regarding the limitations of PGT-A, and of providing standard prenatal care for pregnancies conceived through ART, regardless of whether PGT-A was performed. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 3, 2021 Category: Reproduction Medicine Source Type: research

Competence of embryos showing transient developmental arrest during in vitro culture
AbstractPurposeIn vitro developing embryos may apparently show no developmental progress during 24 h and resume their development up to the blastocyst stage. The present study was conducted to assess their ability to implant and to give rise to a live birth when replaced at day 5 (fresh or vitrified/warmed) as compared to continuously developing embryos.MethodsEmbryo development follow-up and grade were prospectively recorded in a photo database. The studied period was from April 2011 to July 2017. The studied embryos included transient arrested embryos (TAE) that showed the same developmental stage at two subsequent obser...
Source: Journal of Assisted Reproduction and Genetics - February 2, 2021 Category: Reproduction Medicine Source Type: research

Correlation between the DNA fragmentation index (DFI) and sperm morphology of infertile patients
AbstractPurposeTo evaluate the correlation between the DNA Fragmentation Index (DFI) and sperm morphology in patients undergoing ICSI, as a predictive parameter in reproductive outcomes.MethodsA retrospective study was conducted on 125 infertile patients enrolled in a fertility clinic. Seminal characteristics were measured following the WHO guidelines (2010) for the examination of the seminal fluid. After collecting motile sperm population by pellet swim up, DFI was calculated and simultaneously associated with sperm morphology using in situ TUNEL assay and an image analyzer software in at least 250 spermatozoa for each pa...
Source: Journal of Assisted Reproduction and Genetics - February 2, 2021 Category: Reproduction Medicine Source Type: research

Correction to: A prospective randomized trial comparing corifollitropin- α late-start (day 4) versus standard administration (day 2) in expected poor, normal, and high responders undergoing controlled ovarian stimulation for IVF
A Correction to this paper has been published:https://doi.org/10.1007/s10815-021-02091-7 (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 2, 2021 Category: Reproduction Medicine Source Type: research

Patient and provider satisfaction with saline ultrasound versus office hysteroscopy for uterine cavity evaluation prior to in vitro fertilization: a randomized controlled trial
AbstractPurposeTo compare patient and provider satisfaction with saline ultrasound (SIS) versus office hysteroscopy for cavity evaluation prior to in vitro fertilization (IVF) and to assess the capability of hysteroscopy to manage pathology at time of diagnosis to reduce delays and supernumerary procedures.MethodsThis was a randomized, controlled trial in a university fertility clinic. One hundred enrolled subjects undergoing routine uterine cavity evaluation prior to planned embryo transfer were randomized to SIS or office hysteroscopy without anesthesia. Subjects and providers completed surveys about their experience. Su...
Source: Journal of Assisted Reproduction and Genetics - February 1, 2021 Category: Reproduction Medicine Source Type: research

Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8/SVneo cells
ConclusionEndometrial EVs from RIF patients inhibited the functions of trophoblasts by decreasing their proliferation, migration, and invasive capacity. Such dysregulations induced by RIF-EVs may provide novel insights for better understanding the pathogenesis of implantation failure. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 1, 2021 Category: Reproduction Medicine Source Type: research

Expanded carrier screening for recessively inherited disorders: economic burden and factors in decision-making when one individual in a couple is identified as a carrier
ConclusionsNot all carriers of recessively inherited disorders choose to undergo partner screening. Patients found to be carrier of more debilitating genetic disorders may be more likely to screen their reproductive partners. For many, ECS testing is not covered by insurance, and this test may impose a significant economic burden. For some patients, the results of ECS would not change what they would do when seeking conception. Providers should evaluate whether a patient ’s ECS result would change their treatment course prior to testing. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 27, 2021 Category: Reproduction Medicine Source Type: research

The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy
We report the pregnancy and live birth achieved after in vitro maturation (IVM) of oocytes and PGT-A in a 23-year-old patient suffering from ovarian gonadotropin resistance. A woman with resistant ovary syndrome (ROS) had secondary amenorrhea, high FSH levels (25.34 mIU/mL) and LH (29.6 mIU/mL), low estradiol levels (15.2 pg/mL), and high serum AMH levels (38.0 ng/mL), associated with an increased antral follicle count (AFC) of 45. Without gonadotropin priming and HCG trigger, ultrasound-guided transvaginal oocyte retrieval was performed. Aspiration of antral-stage follicles allowed the retrieval of 15 immature oocytes. Af...
Source: Journal of Assisted Reproduction and Genetics - January 26, 2021 Category: Reproduction Medicine Source Type: research

A non-linear dose-response relation of female body mass index and in vitro fertilization outcomes
ConclusionsIn conclusion, obesity contributed to increased risk of adverse IVF outcomes in a non-linear dose-response manner. More prospective trials in evaluating the effect of body weight control are necessary. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 26, 2021 Category: Reproduction Medicine Source Type: research

Fertility preservation for genetic diseases leading to premature ovarian insufficiency (POI)
ConclusionsFertility preservation techniques represent a crucial opportunity for patients with genetic risk of POI. Early diagnosis increases the chances to apply these techniques. No specific recommendations concerning fertility preservation for each genetic pathology are available, and clinicians should first counsel the patient and her relatives about known risks and benefits of the available techniques, both those established and those considered as experimental. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 25, 2021 Category: Reproduction Medicine Source Type: research

A novel homozygous missense mutation of PMFBP1 causes acephalic spermatozoa syndrome
ConclusionOur results showed that the novel homozygous missense mutation ofPMFBP1 may be a cause of acephalic spermatozoa syndrome, which provided a basis for genetic counseling for the patient. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 23, 2021 Category: Reproduction Medicine Source Type: research

Live birth achieved despite the absence of ejaculated spermatozoa and mature oocytes retrieved: a case report
AbstractThe most common reason for in vitro fertilization (IVF) cycle cancelation is a lack of quality gametes available for intracytoplasmic sperm injection (ICSI). Here we present the successful fertility treatment of the couple affected by obstructive azoospermia combined with suboptimal response to controlled ovarian stimulation. Since the conventional approach appeared ineffective to overcome both partners ˈ specific problems, the targeted interventions, namely, (1) pharmacological enhancement of sperm motility and (2) polarized light microscopy (PLM)-guided optimization of ICSI time, were applied to rescue the cycle...
Source: Journal of Assisted Reproduction and Genetics - January 20, 2021 Category: Reproduction Medicine Source Type: research

Extracellular vesicles and female reproduction
AbstractExtracellular vesicles (EVs) are nano-sized membrane bound complexes that have been identified as a mean for intercellular communication between cells and tissues both in physiological and pathological conditions. These vesicles contain numerous molecules involved in signal transduction including microRNAs, mRNAs, DNA, proteins, lipids, and cytokines and can affect the behavior of recipient cells. Female reproduction is dependent on extremely fine-tuned endocrine regulation, and EVs may represent an added layer that contributes to this regulation. This narrative review article provides an update on the research of ...
Source: Journal of Assisted Reproduction and Genetics - January 20, 2021 Category: Reproduction Medicine Source Type: research

Suboptimal trophectoderm mitochondrial DNA level is associated with delayed blastocyst development
ConclusionsOur data provided further evidence D5 blastocysts contained significantly greater mtDNA quantity than D6 blastocysts, and mtDNA quantity could be a key factor that affects the development rate of blastocysts. Furthermore, one must avoid using an arbitrary threshold when incorporating mtDNA quantity into the embryo selection criteria, as the observed value may have vastly different clinical implication when blastulation rate is also considered. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 20, 2021 Category: Reproduction Medicine Source Type: research

Clinical pregnancy is significantly associated with the blastocyst width and area: a time-lapse study
AbstractIn order to maintain pregnancy rates following single embryo transfer, optimisation of embryo culture and selection is vital. Time-lapse monitoring (TLM) has the potential to play a crucial role by providing sequential images of embryo development and minimal disturbance. Therefore, in this study morphometric assessment of blastocyst area and maximum width was performed in order to evaluate if these parameters are associated with pregnancy outcomes in IVF/ICSI cycles. This is a retrospective study of 664 patients who had elective single blastocyst transfer (eSBT). The EmbryoScope drawing tools were used to measure ...
Source: Journal of Assisted Reproduction and Genetics - January 20, 2021 Category: Reproduction Medicine Source Type: research

Severe ovarian hyperstimulation syndrome associated with long-acting GnRH agonist in oncofertility patients
ConclusionsRisk of severe OHSS may be increased when a long-acting GnRH agonist is used for ovarian suppression immediately following oocyte retrieval. A delay in initiating long-acting GnRH agonist after oocyte retrieval in patients at high risk for developing OHSS should be considered. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 20, 2021 Category: Reproduction Medicine Source Type: research

Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis
ConclusionCurrent ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 19, 2021 Category: Reproduction Medicine Source Type: research

A content and quality evaluation of ACGME-accredited reproductive endocrinology and infertility fellowship program webpages
AbstractPurposeTo analyze the content of websites of ACGME-accredited REI fellowship programs in the USA and to determine whether there are differences in content across geographic regions.MethodsAll ACGME-accredited REI fellowship websites active as of September 2020 were evaluated and reviewed using 20 criteria in the following nine domains: program overview, contact information, application information, curriculum, current fellows, research, alumni, faculty, and fellowship benefits. Website content was compared across geographic regions (Northeast, Midwest, South, and West) of the USA. Analyses were completed using chi-...
Source: Journal of Assisted Reproduction and Genetics - January 18, 2021 Category: Reproduction Medicine Source Type: research

Clinical utility of the endometrial receptivity analysis in women with prior failed transfers
ConclusionWomen with ≥ 1 prior failed ET and ≥ 3 prior failed ETs had a similar prevalence of non-receptive endometrium compared to controls. Women with ≥ 3 prior failed ETs had a lower ongoing pregnancy/live birth rate despite a personalized FET, suggesting that there are additional factors in implantation failur e beyond an adjustment in progesterone exposure. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 17, 2021 Category: Reproduction Medicine Source Type: research

Y chromosome structural variation in infertile men detected by targeted next-generation sequencing
ConclusionThe established NGS method can replace the conventional STS-PCR method to detect Y chromosome microdeletions. The NGS method can detect CNV, such as partial deletion or duplication, and provide details of the abnormal range and size of variations. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 16, 2021 Category: Reproduction Medicine Source Type: research

Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion
ConclusionsOur Repro-Can-OPEN Study Part 2 proposed installing specific oncofertility programs for common cancers in optimum resource settings as an extrapolation for best practice models. This will provide efficient oncofertility edification and modeling to oncofertility teams and related healthcare providers around the globe and help them offer the best care possible to their patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 16, 2021 Category: Reproduction Medicine Source Type: research