Albumin used in human IVF contain different levels of lipids and modify embryo and fetal growth in a mouse model
AbstractPurposeDifferent commercial human embryo culture mediums can alter embryo quality and change birthweight. One component that could be contributing to variations but is not widely investigated is human serum albumin (HSA). HSA plays a multitude of roles during embryo culture and is a carrier for molecules including lipids. It remains unclear if lipid composition of HSA varies among commercial products and its effects on embryo quality, implantation, and fetal outcomes are relatively unknown.MethodsUtilizing a mouse model of embryo culture, we cultured zygotes until the blastocyst stage (72-h culture) in G1/G2 contai...
Source: Journal of Assisted Reproduction and Genetics - June 11, 2021 Category: Reproduction Medicine Source Type: research

The impact of the female genital tract microbiome in women health and reproduction: a review
ConclusionFurther research regarding FGT microbiome configuration needs to be done in order to establish a more precise link between microbiota and eubiosis or dysbiosis. Detection of bacterial species related with poor reproductive outcomes, infertility or gynaecological diseases could shape new tools for their diagnosis and treatment, as well as resources to assess the pregnancy prognosis based on endometrial microbiota. Data available suggest future research protocols should be standardised, and it needs to include the interplay among microbiome, virome and mycobiome, and the effect of antibiotics or probiotics on the m...
Source: Journal of Assisted Reproduction and Genetics - June 10, 2021 Category: Reproduction Medicine Source Type: research

Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve
AbstractIn assisted reproductive technology treatment, diminished ovarian reserve (DOR) is a condition of utmost clinical and scientific relevance because of its negative influence on patient outcomes. The current methods of infertility treatment may be unsuitable for many women with DOR, which support the need for development of additional approaches to achieve fertility restoration. Various techniques have been  tried to improve the quality and increase the quantity of oocytes in DOR patients, including mitochondrial transfer, activation of primordial follicles, in vitro culture of follicles, and regeneration of ooc...
Source: Journal of Assisted Reproduction and Genetics - June 7, 2021 Category: Reproduction Medicine Source Type: research

Utilization of in vitro maturation in cases with a FSH receptor mutation
ConclusionsWe report two novel variants of theFSHR. Although IVM successfully matured some oocytes, only one resulted in an embryo with normal TL phenotypes. We recommend FSHR genetic testing in GRS patients, which will help guide their suitability for IVM. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 4, 2021 Category: Reproduction Medicine Source Type: research

Embryo quality, ploidy, and transfer outcomes in male versus female blastocysts
AbstractPurposeThe goal is to determine if variations exist between male and female blastocysts in preimplantation measurements of quality and ploidy andin vitro fertilization elective single-embryo transfer (eSET) outcomes.MethodsA retrospective chart review was conducted from a private fertility center ’s database of blastocysts undergoing preimplantation genetic testing for aneuploidy, along with details of eSET from this screened cohort. Main outcomes included preimplantation embryo quality and sex-specific eSET outcomes.ResultsA total of 3708 embryos from 578 women were evaluated, with 45.9% male and 54.1% femal...
Source: Journal of Assisted Reproduction and Genetics - June 4, 2021 Category: Reproduction Medicine Source Type: research

Authors ’ response to Scriven’s Letter to the Editor (Journal of Assisted Reproduction and Genetics; https://doi.org/10.1007/s10815-021-02139)
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 4, 2021 Category: Reproduction Medicine Source Type: research

Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer
AbstractPurposeTo evaluate embryology and pregnancy outcomes following individual and group embryo culture in the setting of contemporary laboratory practices and freeze-all cycles.MethodsPatients underwent ovarian stimulation followed by intracytoplasmic sperm injection (ICSI). Embryos proceeded through individual culture and then underwent preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy. In a subsequent cycle, participants underwent single embryo transfer of a vitrified-warmed, euploid embryo. Outcomes were compared to controls undergoing group culture during the same time frame. The Mann-...
Source: Journal of Assisted Reproduction and Genetics - June 4, 2021 Category: Reproduction Medicine Source Type: research

What is the optimal timing of intracytoplasmic sperm injection (ICSI) after EGG retrieval? A randomized controlled trial
Conclusion(s)In good prognosis couples, we observed no difference in fertilization or blastulation rates based on timing of ICSI within the currently accepted 2- to 6-h window post-retrieval based on a 34-h trigger. The oocyte appears to have a physiological tolerance for fertilization during this window of time, and variability in the timing of ICSI during this window is unlikely to have an impact on cycle outcome. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 3, 2021 Category: Reproduction Medicine Source Type: research

Detailed cell-level analysis of sperm nuclear quality among the different hypo-osmotic swelling test (HOST) classes
AbstractPurposeWe studied the quality differences between the different hypo-osmotic swelling test (HOST) classes, as measured by criteria of DNA fragmentation, DNA decondensation, and nuclear architecture. The aim was to find particular HOST classes associated with good-quality metrics, which may be potentially used in ICSI (intra-cytoplasmic sperm injection).MethodsTen patients from the Department of Reproductive Medicine at Tenon Hospital (Paris, France) were included. Their semen samples were collected and divided into two fractions: one was incubated in a hypo-osmotic solution as per HOST protocol and sorted by sperm ...
Source: Journal of Assisted Reproduction and Genetics - June 2, 2021 Category: Reproduction Medicine Source Type: research

Multivariate analysis of the factors associated with live births during in vitro fertilisation in Southeast Asia: a cross-sectional study of 104,015 in vitro fertilisation records in Taiwan
This study analyses data from a population-based-assisted reproductive database of all registered artificial reproduction institutions (n = 80) from 2010 to 2016 in Taiwan. The probability of a live birth in correlation with the treatment parameters was measured with multivariate logistic regression analyses using the generalised additive model (GAM) and Pearson ’s chi-square exact test.ResultsA total of 104,015 IVF treatments performed between 2010 and 2016 were included in our analysis. From these treatments, 31,467 (30.3%) were successfully delivered, and 40,565 test-tube babies were born. Pearson ’s chi-squ...
Source: Journal of Assisted Reproduction and Genetics - June 1, 2021 Category: Reproduction Medicine Source Type: research

Uterus transplantation: state of the art in 2021
ConclusionsUterus transplantation is an emerging therapy for absolute uterine factor infertility, a condition previously without direct treatment options. It is paramount that reproductive health care providers are familiar with the uterus transplantation process as more patients seek and receive this treatment. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 31, 2021 Category: Reproduction Medicine Source Type: research

Dysregulation of bisphosphoglycerate mutase during in vitro maturation of oocytes
ConclusionHemoglobin and 2,3-BPG may play a role within the maturing COC. This study shows that IVM increases Bpgm within COCs compared to in vivo. Decreasing oxygen concentration and the addition of hemoglobin altered Bpgm, albeit not to levels observed in vivo. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 30, 2021 Category: Reproduction Medicine Source Type: research

Copy number variation sequencing combined with quantitative fluorescence polymerase chain reaction in clinical application of pregnancy loss
ConclusionOur study suggests that CNV-seq and QF-PCR are efficient and reliable technologies in the fetal chromosome analysis of miscarriages and could be used as a routine selection method for the genetic analysis of spontaneous abortion. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 30, 2021 Category: Reproduction Medicine Source Type: research

The slippery slope antedating syngamy: pronuclear activity in preparation for the first cleavage
AbstractNucleolus precursor bodies (NPB) are aggregations of intrapronuclear material observed in the pronuclei of fertilized human eggs. They derive from and evolve into nucleoli of the growing oocyte and the early embryo, respectively. Decades-old observations suggest that the patterns of their distribution represent a morphological marker of embryo developmental competence. Recent time-lapse microscopy (TLM) data now indicate that the vectorial characteristics of NPB movement can predict blastocyst formation, euploidy, and implantation. Since distributions of NPB and chromatin coincide, chromatin rearrangement in prepar...
Source: Journal of Assisted Reproduction and Genetics - May 30, 2021 Category: Reproduction Medicine Source Type: research

Involvement of single nucleotide polymorphisms in ovarian poor response
ConclusionsDespite a higher prevalence ofAMHR2,LHCGR,MTHFR, andSERPINE1 variations in the patients with poor ovarian response, it seems that these variations are not associated with the ovarian response. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 29, 2021 Category: Reproduction Medicine Source Type: research

Finding consensus as the clock turns: truncating the time to birth
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 29, 2021 Category: Reproduction Medicine Source Type: research

A threshold concentration of FSH is needed during IVM of ex vivo collected human oocytes
ConclusionFSH improved oocyte nuclear maturation at concentrations above 70 IU/L suggesting a threshold for FSH during IVM of ex vivo collected human oocytes from small antral follicles. Moreover, current results for the first time highlight that FSH function in vitro is mediated via cumulus cells by downregulatingFSHR and upregulatingLHCGR, which was also observed when the immature oocytes progressed in meiosis from the GV to the MII stage. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 28, 2021 Category: Reproduction Medicine Source Type: research

β-estradiol promotes the growth of primary human fetal spermatogonial stem cells via the induction of stem cell factor in Sertoli cells
ConclusionHere we report, for the first time, that β-estradiol can induce the increase of SCF expression in human fetal Sertoli cells and regulates the growth and survival of human fetal SSCs. These novel findings provide new perspectives on the current understanding of the role of estrogen in human spermatogenesis. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 28, 2021 Category: Reproduction Medicine Source Type: research

Altered redox status may contribute to aberrant folliculogenesis and poor reproductive outcomes in women with polycystic ovary syndrome
ConclusionOur data indicates disrupted redox homeostasis in follicular environment in PCOS which may negatively influence oocyte/embryo quality. Further, granulosa cells may play crucial role in maintaining follicular redox homeostasis. Glutathione system and paraoxonase1 could be explored further as surrogates for IVF prognosis/outcome. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 26, 2021 Category: Reproduction Medicine Source Type: research

Two novel mutations in PADI6 and TLE6 genes cause female infertility due to arrest in embryonic development
ConclusionsOur findings expand the mutational spectrum ofPADI6 andTLE6 associated with embryonic developmental arrest and deepen our understanding of the genetic causes of infertility with recurrent ART failure. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 26, 2021 Category: Reproduction Medicine Source Type: research

Condition, disease, disability: how the label used to describe infertility may affect public support for fertility treatment coverage
AbstractPurposeTo assess public attitudes towards fertility treatment coverage and whether attitudes are influenced by infertility labels.MethodsCross-sectional, web survey-based experiment using a national sample of 1226 United States adults. Participants read identical descriptions about infertility, with the exception of random assignment to infertility being labeled as a “condition,” “disease,” or “disability.” Participants then responded to questions measuring their beliefs and attitudes towards policies related to the diagnosis and treatment of infertility. We measured public suppo...
Source: Journal of Assisted Reproduction and Genetics - May 26, 2021 Category: Reproduction Medicine Source Type: research

ART outcomes following ovarian stimulation in the luteal phase:a systematic review and meta-analysis
ConclusionCurrent evidence indicates that patients in the LPS group could achieve pregnancy outcomes non-inferior to those in the FPS group. Because of current debate over freeze-all policy and the limited data about live birth rate, the universal use of LPS is considered controversial. In the future, more well-designed studies are necessary to investigate the indications for LPS and its cost-effectiveness. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2021 Category: Reproduction Medicine Source Type: research

PGT-A: who and when? Α systematic review and network meta-analysis of RCTs
ConclusionPGT-A did not improve clinical outcomes for the general population, however PGT-A improved live-birth rates strictly when performed on blastocyst stage embryos of women over the 35-year-old mark. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2021 Category: Reproduction Medicine Source Type: research

Effect of polymorphisms of MTHFR in controlled ovarian stimulation: a systematic review and meta-analysis
ConclusionStudies to date indicate that polymorphisms of MTHFR could influence basal FSH level and FSH dose. The results could be useful to promote clinical practice on COS protocols. Further studies are needed to evaluate the clinical relevance of the multigene combination on COS. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 25, 2021 Category: Reproduction Medicine Source Type: research

Effect of oxygen and glucose availability during in vitro maturation of bovine oocytes on development and gene expression
ConclusionOocyte developmental competence is negatively impacted following IVM in low oxygen when glucose availability is limited. Glucose concentration and physical culture conditions need to be considered when comparing the effects of different oxygen concentrations during IVM. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 24, 2021 Category: Reproduction Medicine Source Type: research

Can methods of artificial intelligence aid in optimizing patient selection in patients undergoing intrauterine inseminations?
ConclusionAmong the compared methods, the random forest and PLS models demonstrated superior performance in predicting the clinical outcome of IUI. With additional research and clinical validation, AI methods may be successfully used in improving patient selection and consequently lead to better clinical results. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 24, 2021 Category: Reproduction Medicine Source Type: research

Does gonadotropin-releasing hormone agonist cause luteolysis by inducing apoptosis of the human granulosa-luteal cells?
AbstractObjectivesTo evaluates the effect of different modes of final follicular maturation triggering on the degree of apoptosis of granulosa cells (GCs) and the potential effect on progesterone secretion.MethodsThirty patients undergoing controlled ovarian hyperstimulation for IVF who received hCG, GnRH agonist, or dual trigger for final follicular maturation were included in the study. Granulosa cells were obtained at the time of oocyte retrieval. The proportion of apoptotic cells was evaluated via TUNEL and immunohistochemistry.ResultsThe proportion of apoptotic cells was significantly higher in the GnRH agonist &ndash...
Source: Journal of Assisted Reproduction and Genetics - May 24, 2021 Category: Reproduction Medicine Source Type: research

End-to-end deep learning for recognition of ploidy status using time-lapse videos
ConclusionOur model demonstrated a proof of concept and potential in recognizing the ploidy status of tested embryos. A larger scale and further optimization on the exclusion criteria would be included in our future investigation, as well as prospective approach. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 22, 2021 Category: Reproduction Medicine Source Type: research

Mouse oocyte vitrification with and without dimethyl sulfoxide: influence on cryo-survival, development, and maternal imprinted gene expression
Conclusion(s)Inclusion of DMSO in oocyte vitrification solutions improved cryo-survival and developmental potential of parthenogenetic embryos to the blastocyst stage without significantly altering maternal imprinted gene expression. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 22, 2021 Category: Reproduction Medicine Source Type: research

Morphology-based selection from available euploid blastocysts induces male-skewed sex proportion in the offspring
ConclusionBlastocyst features associated with a skewed sex proportion towards XY embryos, such as biopsy on day 5 and top quality TE, are also parameters used for selecting euploid embryos for SET. Therefore, our data suggest that morphology-based embryo selection represents a strong factor responsible for a skewed male sex proportion at birth in PGT-A cycles. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 19, 2021 Category: Reproduction Medicine Source Type: research

The presence of cytoplasmic strings in human blastocysts is associated with the probability of clinical pregnancy with fetal heart
ConclusionThis study has shown that the presence of cytoplasmic strings in human blastocysts is associated with the probability of clinical pregnancy with fetal heart. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 19, 2021 Category: Reproduction Medicine Source Type: research

Elevated serum progesterone does not impact euploidy rates in PGT-A patients
AbstractPurposeSome women undergoing stimulated cycles have elevated serum progesterone (P) on the day of ovulation trigger, but its effect on embryo quality is unclear. We analyze embryo quality among patients with high and low serum P undergoing preimplantation genetic testing for aneuploidy (PGT-A).MethodsThis retrospective study included 1597 patients divided into two groups by serum P values:
Source: Journal of Assisted Reproduction and Genetics - May 18, 2021 Category: Reproduction Medicine Source Type: research

Infertility and the power of word choice
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 17, 2021 Category: Reproduction Medicine Source Type: research

The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress –induced mice
ConclusionOur findings suggest that sirtuin-1 may play a role in embryo implantation against oxidative stress through FoxO1-SOD signaling. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 15, 2021 Category: Reproduction Medicine Source Type: research

Flow-cytometric analysis of membrane integrity of stallion sperm in the face of agglutination: the “zombie sperm” dilemma
ConclusionFlow cytometry assesses only individualized sperm; thus, agglutination of viable sperm alters recorded membrane integrity. As viable sperm become immotile, they individualize; therefore, factors that decrease motility, such as A23187, result in increased measured MI. Disaggregation before assessment allows more accurate determination of sperm membrane status; in this case we documented a mismatch between motility and live acrosome-reacted equine sperm that may relate to the poor repeatability of A23187 treatment for equine IVF. These findings are of profound value to future studies on sperm capacitation. (Source:...
Source: Journal of Assisted Reproduction and Genetics - May 15, 2021 Category: Reproduction Medicine Source Type: research

Correction to: Deep learning early warning system for embryo culture conditions and embryologist performance in the ART laboratory
A Correction to this paper has been published:https://doi.org/10.1007/s10815-021-02225-x (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 14, 2021 Category: Reproduction Medicine Source Type: research

Distribution of diandric and digynic triploidy depending on gestational age
ConclusionsThe distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 13, 2021 Category: Reproduction Medicine Source Type: research

Reproductive outcomes of microdissection testicular sperm extraction in hypogonadotropic hypogonadal azoospermic men after gonadotropin therapy
ConclusionGonadotropin therapy reversed azoospermia in a portion of the HH male patients studied. Of men who were still azoospermic after gonadotropin treatment, a majority could still have testicular sperm retrieved by mTESE for use in assisted reproductive technology, subsequently resulting in live births. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 12, 2021 Category: Reproduction Medicine Source Type: research

Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape
ConclusionsAltogether, our results show that Atp1a4 plays an important role in maintaining the proper shape of the sperm flagellum through both osmotic control and structurally related mechanisms. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 12, 2021 Category: Reproduction Medicine Source Type: research

Oocyte cryopreservation versus ovarian tissue cryopreservation for adult female oncofertility patients: a cost-effectiveness study
ConclusionsWith current published prices and utilization, OC is more costly but more effective than OTC. OC becomes cost-saving with increased utilization, when cost of OC prior to chemotherapy is markedly low, cost of laparoscopy is high, or standardized discounted oncofertility pricing is assumed. We identify the critical thresholds of OC and OTC that should be met to deliver more cost-effective care for oncofertility patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 11, 2021 Category: Reproduction Medicine Source Type: research

The probable destructive mechanisms behind COVID-19 on male reproduction system and fertility
ConclusionThere is a concern that male fertility may be disturbed after the SARS-CoV-2 infection. Therefore, follow-up of the reproductive functions and male fertility may be necessary in recovered cases, especially in aged men. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 11, 2021 Category: Reproduction Medicine Source Type: research

Mural granulosa cells support to maintain the viability of growing porcine oocytes and its developmental competence after insemination
AbstractPurposeTo enhance the in vitro growth of porcine oocytes, we studied the effect of mural granulosa cells (MGCs) on the viability of oocytes attached to granulosa cells (oocyte-granulosa cell complexes, OGCs) that were obtained from early antral follicles.Methods and resultsWhen OGCs were cultured with MGCs for 12 days, there were significant improvement (P
Source: Journal of Assisted Reproduction and Genetics - May 10, 2021 Category: Reproduction Medicine Source Type: research

The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility
ConclusionsOur study expands the spectrum ofTUBB8 variants, particularly for embryonic arrest. Together with the extant knowledge ofTUBB8 variants, this study provides a foundation for the genetic counselling of female infertility. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 10, 2021 Category: Reproduction Medicine Source Type: research

Triggering change in stimulation protocols: a matter of oocyte maturation and beyond
AbstractSince the birth of Louise Brown, in vitro fertilization (IVF) stimulation protocols have evolved significantly. One particular area of focus has been the process of final oocyte maturation, during which the oocyte gains competence to support fertilization and early embryonic development up to implantation. The field of human assisted reproductive technology (ART) is witnessing increased utilization of GnRH agonists (GnRHa) as trigger agents, in addition to or instead of the traditionally used human chorionic gonadotropin (hCG). Future translational studies will reveal whether oocyte developmental competence, as ref...
Source: Journal of Assisted Reproduction and Genetics - May 10, 2021 Category: Reproduction Medicine Source Type: research

The time is ripe for oocyte in vitro maturation
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 8, 2021 Category: Reproduction Medicine Source Type: research

Comparison of in vitro fertilization/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age: overlooked details
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 7, 2021 Category: Reproduction Medicine Source Type: research

Exposure to epididymal extracellular vesicles enhances immature sperm function and sustains vitality of cryopreserved spermatozoa in the domestic cat model
ConclusionsEpididymal EVs contain multiple factors contributing to immature sperm function, specifically enhancing the ability to complete a faster pronuclear apposition with subsequently improved early embryonic development. Supplementation was also beneficial to the motility of spermatozoa that had undergone cryopreservation. Those new findings could lead to new options for male fertility treatment in animal models and humans. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 5, 2021 Category: Reproduction Medicine Source Type: research

Correction to: Dehydroepiandrosterone sulphate (DHEAS) concentrations stringently regulate fertilization, embryo development and IVF outcomes: are we looking at a potentially compelling ‘oocyte-related factor’ in oocyte activation?
ConclusionRectification of deviated DHEAS levels post-treatment significantly improves outcomes, comparable with those exhibited by normal-control DHEAS thresholds. DHEAS is the most promising endogenous oocyte-related factor influencing embryologic, clinical IVF outcomes possibly by affecting oocyte-activation. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 4, 2021 Category: Reproduction Medicine Source Type: research

A comprehensive PGT-M strategy for ADPKD patients with de novo PKD1 mutations using affected embryo or gametes as proband
This study provides a creative approach for embryo diagnosis of patients withde novo mutations or patients who lack essential family members for linkage analysis. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - May 3, 2021 Category: Reproduction Medicine Source Type: research

Response to ovulation induction treatments in women with polycystic ovary syndrome as a function of serum anti-M üllerian hormone levels
AbstractPurposeTo assess whether anti-M üllerian hormone (AMH) can predict response to ovulation induction (OI) with clomiphene citrate (CC), letrozole (LET), or follicle-stimulating hormone (FSH) in women with polycystic ovary syndrome (PCOS) undergoing OI/intrauterine inseminations (IUI).MethodsA total of 738 OI/IUI cycles from 242 patients at an academic center were stratified in three groups by medication: CC (n = 295), LET (n = 180), and FSH (n = 263), in a retrospective fashion. Ovarian response to treatment (RT, development of at least one dominant follicle) was assessed using mixed effects logistic regression ...
Source: Journal of Assisted Reproduction and Genetics - May 1, 2021 Category: Reproduction Medicine Source Type: research