Journal of Assisted Reproduction and Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In Memoriam: Dr. Robert N. Taylor MD, PhD
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 27, 2024 Category: Reproduction Medicine Source Type: research

Impact of mildly evaluated thyroid-stimulating hormone levels on in vitro fertilization or intracytoplasmic sperm injection outcomes in women with the first fresh embryo transfer: a large study from China
ConclusionMildly elevated pre-conception TSH levels in thyroid-normal infertile patients did not have an impact on pregnancy outcomes of IVF/ICSI treatments. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 26, 2024 Category: Reproduction Medicine Source Type: research

Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential
ConclusionsSperm genome profiling provides invaluable information on azoospermia etiology and identifies gene-related mechanistic links to reproductive performance. Moreover, RNAseq assessment of seminal fluid from NOA men can help predict sperm retrieval during testicular biopsies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 26, 2024 Category: Reproduction Medicine Source Type: research

Impact of mildly evaluated thyroid-stimulating hormone levels on in vitro fertilization or intracytoplasmic sperm injection outcomes in women with the first fresh embryo transfer: a large study from China
ConclusionMildly elevated pre-conception TSH levels in thyroid-normal infertile patients did not have an impact on pregnancy outcomes of IVF/ICSI treatments. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 26, 2024 Category: Reproduction Medicine Source Type: research

Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential
ConclusionsSperm genome profiling provides invaluable information on azoospermia etiology and identifies gene-related mechanistic links to reproductive performance. Moreover, RNAseq assessment of seminal fluid from NOA men can help predict sperm retrieval during testicular biopsies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 26, 2024 Category: Reproduction Medicine Source Type: research

Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development
AbstractAneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic abnormalities in preimplantation embryos are the main cause of mosaicism, which may be influenced by several endogenous factors such as relaxation of cell cycle control mechanisms, defects in chromosome cohesion, centrosome aberrations and abnormal spindle assembly, and DNA replication stress. In addition, incomplete trisomy rescue is a rare cause of mosaicism. However, there may be a self-correcting mechanism in mosaic embryos, which allows some mosaicisms to potentially develop into normal embryos. At present, it is di...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Indications affect neonatal outcomes following early rescue ICSI: a retrospective study
ConclusionEarly rICSI in patients with total fertilization failure (TFF) appeared to be safe in terms of neonatal outcomes. However, when expanding the indications of rICSI to PFF patients, the SGA in the offspring increased, suggesting a potential effect on long-term health. Since other treatment options, such as using only the IVF-origin embryos still exist for these patients, further studies were needed to confirm the optimal decision for these patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Preimplantation genetic testing for aneuploidy: predictive embryonic factors
ConclusionsExcellent-quality and day 5 –biopsied embryos are more prone to be euploid than good and poor or day 6–biopsied embryos, respectively. Poor-quality, day 6–biopsied embryos, and FHB have significantly lower survival after biopsy and vitrification. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Impact of vaginal microecological differences on pregnancy outcomes and endometrial microbiota in frozen embryo transfer cycles
ConclusionThis study highlights that normal vaginal microecology, characterized by lower pH and leukocyte esterase negativity, is associated with a higher likelihood of clinical pregnancy following FET. Importantly, vaginal microecological differences influence endometrial microbiota composition. Moreover, transvaginalLactobacillus supplementation appears promising in improving clinical pregnancy rates in patients with previous failed cycles. These findings contribute to a better understanding of the interplay between vaginal and endometrial microbiota and offer potential interventions to enhance reproductive success in as...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development
AbstractAneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic abnormalities in preimplantation embryos are the main cause of mosaicism, which may be influenced by several endogenous factors such as relaxation of cell cycle control mechanisms, defects in chromosome cohesion, centrosome aberrations and abnormal spindle assembly, and DNA replication stress. In addition, incomplete trisomy rescue is a rare cause of mosaicism. However, there may be a self-correcting mechanism in mosaic embryos, which allows some mosaicisms to potentially develop into normal embryos. At present, it is di...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Indications affect neonatal outcomes following early rescue ICSI: a retrospective study
ConclusionEarly rICSI in patients with total fertilization failure (TFF) appeared to be safe in terms of neonatal outcomes. However, when expanding the indications of rICSI to PFF patients, the SGA in the offspring increased, suggesting a potential effect on long-term health. Since other treatment options, such as using only the IVF-origin embryos still exist for these patients, further studies were needed to confirm the optimal decision for these patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Preimplantation genetic testing for aneuploidy: predictive embryonic factors
ConclusionsExcellent-quality and day 5 –biopsied embryos are more prone to be euploid than good and poor or day 6–biopsied embryos, respectively. Poor-quality, day 6–biopsied embryos, and FHB have significantly lower survival after biopsy and vitrification. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Impact of vaginal microecological differences on pregnancy outcomes and endometrial microbiota in frozen embryo transfer cycles
ConclusionThis study highlights that normal vaginal microecology, characterized by lower pH and leukocyte esterase negativity, is associated with a higher likelihood of clinical pregnancy following FET. Importantly, vaginal microecological differences influence endometrial microbiota composition. Moreover, transvaginalLactobacillus supplementation appears promising in improving clinical pregnancy rates in patients with previous failed cycles. These findings contribute to a better understanding of the interplay between vaginal and endometrial microbiota and offer potential interventions to enhance reproductive success in as...
Source: Journal of Assisted Reproduction and Genetics - February 22, 2024 Category: Reproduction Medicine Source Type: research

Reassessing the impact of letrozole co-administration in controlled ovarian hyperstimulation: findings from a single-center repeated measures study
ConclusionsDespite improved oocyte yield, letrozole did not yield any difference in oocyte maturation or embryo outcomes. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 21, 2024 Category: Reproduction Medicine Source Type: research