Journal of Assisted Reproduction and Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case –control study
ConclusionsThe re-biopsy intervention seems to considerably reduce the pregnancy potential of a blastocyst. However, a greater sample size is necessary to clarify this issue definitively. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - April 1, 2024 Category: Reproduction Medicine Source Type: research

Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels
ConclusionHigher concentrations of several phthalate metabolites, present among others in personal care products, were associated with increased E2 levels in FF. The results emphasize the need to further investigate the mechanisms of action of such EDCs on hormonal cyclicity and fertility in women. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - April 1, 2024 Category: Reproduction Medicine Source Type: research

Identification novel mutations and phenotypic spectrum expanding in PATL2 in infertile women with IVF/ICSI failure
ConclusionsThese results expand the spectrum ofPATL2 variants and provide an important reference for genetic counseling for female infertility, and they increase our understanding of the mechanisms of oocyte maturation arrest caused by PATL2 deficiency. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 27, 2024 Category: Reproduction Medicine Source Type: research

Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia
ConclusionExosomal miR-3198 in the maternal peripheral blood may regulate the biological functions of trophoblasts by targeting WNT3 and influence the development of diseases of placental origin.Graphical Abstract (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 27, 2024 Category: Reproduction Medicine Source Type: research

Pathologic maternal and neonatal outcomes associated with programmed embryo transfer: potential etiologies and strategies for prevention
ConclusionsEndometrial preparation that is not optimal, absent circulating corpus luteal factors, or a combination thereof are attractive etiologies; however, the requisite investigations to prove them have yet to be undertaken. Presuming that in ongoing RCTs, some or all adverse pregnancy outcomes associated with programmed autologous FET are circumvented or mitigated by employing natural or stimulated cycles instead, then for women who can conceive using these regimens, they would be preferable. For the 15% or so of women who require programmed FET, additional research as suggested in this review is needed to elucidate t...
Source: Journal of Assisted Reproduction and Genetics - March 27, 2024 Category: Reproduction Medicine Source Type: research

Pathologic maternal and neonatal outcomes associated with programmed embryo transfer
ConclusionsProgrammed autologous FET is associated with an increased risk of several, seemingly diverse, pathologic pregnancy outcomes including HDP, preeclampsia, fetal overgrowth, postterm birth, and placenta accreta. Though the greater risk for preeclampsia specifically associated with programmed autologous FET appears to be well established, further research is needed to substantiate the limited data currently available suggesting that the classification of preeclampsia involved is predominately late-onset or term. If substantiated, then this knowledge could provide insight into placental pathogenesis, which has been p...
Source: Journal of Assisted Reproduction and Genetics - March 27, 2024 Category: Reproduction Medicine Source Type: research

Expression of long non-coding RNA GAS5 by first trimester screening predicts the occurrence of gestational hypertension and pre-eclampsia
ConclusionElevated serum GAS5 could serve as an effective diagnostic biomarker in discriminating GH patients from healthy people by first trimester screening. Detection of serum GAS5 level has a certain predictive value for PE. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 26, 2024 Category: Reproduction Medicine Source Type: research

Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss
ConclusionDownregulation of YAP1 induces ferroptosis, thereby damaging the trophoblast invasion processes, which also disturbs the communication at the maternal-fetal interface. Our study identified YAP1 as a potential key molecule in the pathogenesis of RPL. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 25, 2024 Category: Reproduction Medicine Source Type: research

Obstetric and maternal outcomes of IVF and oocyte donation pregnancies among women ages 40 –45—a large cohort study
ConclusionsWomen ages 40 –45 undergoing IVF or OD have a greater risk of PTL, possibly due to higher rates of hypertensive disorders of pregnancy. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 23, 2024 Category: Reproduction Medicine Source Type: research