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Risks of using mitoquinone during in vitro maturation and its potential protective effects against lipotoxicity-induced oocyte mitochondrial stress
ConclusionOocyte exposure to MitoQ may disturb mitochondrial bioenergetic functions and developmental capacity due to a TPP-induced cationic overload. A fine-tuned concentration of MitoQ can protect against lipotoxicity-induced mitochondrial stress during IVM and restore developmental competence and embryo quality. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 26, 2023 Category: Reproduction Medicine Source Type: research

Long-term health risk of offspring born from assisted reproductive technologies
AbstractSince the world ’s first in vitro fertilization baby was born in 1978, there have been more than 8 million children conceived through assisted reproductive technologies (ART) worldwide, and a significant proportion of them have reached puberty or young adulthood. Many studies have found that ART increases the ris k of adverse perinatal outcomes, including preterm birth, low birth weight, small size for gestational age, perinatal mortality, and congenital anomalies. However, data regarding the long-term outcomes of ART offspring are limited. According to the developmental origins of health and disease theory, adve...
Source: Journal of Assisted Reproduction and Genetics - December 26, 2023 Category: Reproduction Medicine Source Type: research

Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin
ConclusionsThe 8-cell human embryo may be secreting oxytocin, which could stimulate its own progress down the fallopian tube as well as play a role in early neural precursor development. The 8-cell embryo does not synthesize reproductive steroid hormones. As previously reported for growth factor families, the early embryo over-expresses more hormones than hormone receptors. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 22, 2023 Category: Reproduction Medicine Source Type: research

The impact of fresh versus frozen-thawed embryos on maternal serum analyte levels in IVF singleton and twin pregnancies
ConclusionSingleton pregnancies derived from fresh embryos had lower first (free β-hCG) and second (uE3 and AFP) trimester analytes compared to frozen-thawed embryos. Twin pregnancies demonstrated no difference between the groups. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 22, 2023 Category: Reproduction Medicine Source Type: research

An overview of CFTR mutation profiles and assisted reproductive technology outcomes in Chinese patients with congenital obstructive azoospermia
ConclusionApart from the IVS9-5T mutation, the genetic mutation pattern ofCFTR in Chinese OA patients is heterogeneous, which is significantly different from that of Caucasians. Although carrying twoCFTR mutations or not had no effect on the pregnancy outcomes in OA patients after ICSI, genetic counseling is still recommended for such patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 20, 2023 Category: Reproduction Medicine Source Type: research

Correction to: Does cleavage stage morphology increase the discriminatory power of prediction in blastocyst transfer outcome?
(Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 18, 2023 Category: Reproduction Medicine Source Type: research

Identification of cryptic balanced translocations in couples with unexplained recurrent pregnancy loss based upon embryonic PGT-A results
ConclusionA normal karyotype does not eliminate the possibility of carrying BT for couples with uRPL. The use of PGT-A allows us to perceive the “carrier couples” missed by karyotyping analysis, providing an increased risk of finding cryptic BTs if similar SVs are always detected on two chromosomes among multiple embryos. Nonetheless, certain carriers with translocated segments of sub-resolution may still go unnoticed. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 16, 2023 Category: Reproduction Medicine Source Type: research

Bacterial vaginosis in a subfertile population undergoing fertility treatments: a prospective cohort study
ConclusionBacterial vaginosis does not significantly impact ongoing pregnancy rates but could affect miscarriage rates. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 13, 2023 Category: Reproduction Medicine Source Type: research