PD-L1 Expression in Unresectable Locally Advanced or Metastatic Skin Squamous Cell Carcinoma Treated with Anti-Epidermal Growth Factor Receptor Agents
Conclusion: PD-L1 expression in microenvironment predicted better PFS. The combination of EGFR inhibitors and ICB could help deepening the knowledge about the interrelations between the EGFR and PD-1/PD-L1 pathways.Oncology (Source: Oncology)
Source: Oncology - May 21, 2019 Category: Cancer & Oncology Source Type: research

Racial Disparities, Outcomes, and Surgical Utilization among Hispanics with Esophageal Cancer: A Surveillance, Epidemiology, and End Results Program Database Analysis
Conclusions: A lower rate of surgery among Hispanics with potentially resectable esophageal cancer was associated with a decreased survival rate when compared to whites, even when adjusting for relevant socioeconomic and tumor factors. These data support the need to better address patient barriers to surgical treatment and the systemic biases present in medical care.Oncology (Source: Oncology)
Source: Oncology - May 20, 2019 Category: Cancer & Oncology Source Type: research

A Specific Type of Tibetan Medicine Meditation for Women with Breast Cancer: A Pilot Survey
Conclusions: This study shows for the first time that a specific form of Tibetan medicine meditation is efficacious in decreasing the psychological distress in women with breast cancer and can be an important complementary therapy to oncological care.Oncology (Source: Oncology)
Source: Oncology - May 15, 2019 Category: Cancer & Oncology Source Type: research

A Specific Type of Tibetan Medicine Meditation for Women with Breast Cancer: A Pilot Survey.
Abstract BACKGROUND: Breast cancer is one of the most common tumors in the world and is associated with high psychological distress such as depression, anxiety, and stress. Meditation is efficacious to reduce psychological distress, but there are no studies which have evaluated a specific type of Tibetan medicine meditation in patients with breast cancer. The present research aimed to understand the effect a specific type of Tibetan medicine meditation on psychological distress in a sample of women with breast cancer. METHODS: Sixty-two women with breast cancer were enrolled. We instructed the patients in Tib...
Source: Oncology - May 15, 2019 Category: Cancer & Oncology Authors: Pagliaro G, Bernardini F Tags: Oncology Source Type: research

Hemiablation of Localized Prostate Cancer by High-Intensity Focused Ultrasound: A Series of 35 Cases
Prostate cancer (PrC) is one of the most common tumors diagnosed in men. The detection rate of localized PrC has been dramatically enhanced by screening and the development of visualization methods. There are currently several techniques for focal treatment available, among which the most interesting in our opinion is high-intensity focused ultrasound (HIFU). Currently, HIFU hemiablation of PrC is not an established treatment, although evidence of its effectiveness and safety is growing. We have been performing HIFU hemiablation since 2013 and here report our results to add to the evidence on the effectiveness of the techn...
Source: Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival
Conclusions: Our results show strong associations of NT/TRK expression with melanoma stage progression and a poor prognosis.Oncology (Source: Oncology)
Source: Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Hemiablation of Localized Prostate Cancer by High-Intensity Focused Ultrasound: A Series of 35 Cases.
Abstract Prostate cancer (PrC) is one of the most common tumors diagnosed in men. The detection rate of localized PrC has been dramatically enhanced by screening and the development of visualization methods. There are currently several techniques for focal treatment available, among which the most interesting in our opinion is high-intensity focused ultrasound (HIFU). Currently, HIFU hemiablation of PrC is not an established treatment, although evidence of its effectiveness and safety is growing. We have been performing HIFU hemiablation since 2013 and here report our results to add to the evidence on the effectiv...
Source: Oncology - May 9, 2019 Category: Cancer & Oncology Authors: Glybochko PV, Amosov AV, Krupinov GE, Petrovskii NV, Lumpov IS Tags: Oncology Source Type: research

Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival.
We examined whether NT/TRK expression differs across different cutaneous melanoma grades and subtypes, and whether it is associated with melanoma prognosis and survival. A cross-sectional study was performed in which the expression of TrkA, TrkB, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) was analyzed by immunohistochemistry of 154 melanoma samples. We investigated NT/TRK expression associations with prognostic factors for melanoma, relapse-free survival (RFS), and overall survival (OS). RESULTS: Of the 154 melanoma samples, 77 (55.4%) were TrkA immunopositive, 81 (58.3%) were TrkB immunop...
Source: Oncology - May 9, 2019 Category: Cancer & Oncology Authors: Antunes LCM, Cartell A, de Farias CB, Bakos RM, Roesler R, Schwartsmann G Tags: Oncology Source Type: research

Prognostic Impact of Microsatellite Instability in Asian Gastric Cancer Patients Enrolled in the ARTIST Trial
Conclusions: MSI-high status was associated with specific clinical-pathological features and a trend toward better outcomes of Asian GC patients.Oncology (Source: Oncology)
Source: Oncology - May 5, 2019 Category: Cancer & Oncology Source Type: research

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma
Conclusion: Elevated pretreatment NLR, PLR, PLT, and neutrophil count are associated with shorter OS and PFS in patients with mRCC. NLR and PLR are independent prognostic factors for OS. However, PLR and neutrophil count are independent prognostic factors for PFS.Oncology (Source: Oncology)
Source: Oncology - May 5, 2019 Category: Cancer & Oncology Source Type: research

Long-Term Survival and Cure in Distant Metastatic Breast Cancer
Conclusion: Since long-term survivors in MBC comprise a relatively heterogeneous group, the factors that lead to the quite rare and felicitous case of long-term survival or even cure can hardly be evaluated systematically. Some patients may be considered cured of their disease. This fraction may be small, but the chance of survival, and even of cure, truly exists. Perhaps we must accept that the factors contributing to long-term survival remain an enigma. It appears, however, that aggressive chemotherapy is not the only key factor to long-term remission.Oncology (Source: Oncology)
Source: Oncology - May 5, 2019 Category: Cancer & Oncology Source Type: research

Long-Term Survival and Cure in Distant Metastatic Breast Cancer.
CONCLUSION: Since long-term survivors in MBC comprise a relatively heterogeneous group, the factors that lead to the quite rare and felicitous case of long-term survival or even cure can hardly be evaluated systematically. Some patients may be considered cured of their disease. This fraction may be small, but the chance of survival, and even of cure, truly exists. Perhaps we must accept that the factors contributing to long-term survival remain an enigma. It appears, however, that aggressive chemotherapy is not the only key factor to long-term remission. PMID: 31055570 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 3, 2019 Category: Cancer & Oncology Authors: Güth U, Elfgen C, Montagna G, Schmid SM Tags: Oncology Source Type: research

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma.
CONCLUSION: Elevated pretreatment NLR, PLR, PLT, and neutrophil count are associated with shorter OS and PFS in patients with mRCC. NLR and PLR are independent prognostic factors for OS. However, PLR and neutrophil count are independent prognostic factors for PFS. PMID: 31048577 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 2, 2019 Category: Cancer & Oncology Authors: Huszno J, Kolosza Z, Mrochem-Kwarciak J, Rutkowski T, Skladowski K Tags: Oncology Source Type: research

Prognostic Impact of Microsatellite Instability in Asian Gastric Cancer Patients Enrolled in the ARTIST Trial.
CONCLUSIONS: MSI-high status was associated with specific clinical-pathological features and a trend toward better outcomes of Asian GC patients. PMID: 31048579 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 2, 2019 Category: Cancer & Oncology Authors: Miceli R, An J, Di Bartolomeo M, Morano F, Kim ST, Park SH, Choi MG, Lee JH, Raimondi A, Fucà G, Sohn TS, Bae JM, Kim S, Lim DH, Kang WK, Kim KM, Pietrantonio F, Lee J Tags: Oncology Source Type: research

Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review
Conclusions: By critically evaluating high-level evidence in a rigorous manner, this review highlights the general lack of consensus regarding what defines symptom control in studies of carcinoid syndrome and the need for standardized treatment guidelines for this disease. More prospective trials of treatments for carcinoid syndrome are warranted to assist oncologists with optimizing treatment selection and sequencing in this patient population.Oncology (Source: Oncology)
Source: Oncology - April 24, 2019 Category: Cancer & Oncology Source Type: research

Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review.
CONCLUSIONS: By critically evaluating high-level evidence in a rigorous manner, this review highlights the general lack of consensus regarding what defines symptom control in studies of carcinoid syndrome and the need for standardized treatment guidelines for this disease. More prospective trials of treatments for carcinoid syndrome are warranted to assist oncologists with optimizing treatment selection and sequencing in this patient population. PMID: 31018209 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 24, 2019 Category: Cancer & Oncology Authors: Wolin EM, Benson Iii AB Tags: Oncology Source Type: research

Intrahepatic Oxaliplatin and Systemic 5-FU +/ – Cetuximab in Chemo-Naïve Patients with Liver Metastases from Colorectal Cancer
Conclusions: Intrahepatic infusion of oxaliplatin in 10 min with systemic 5-FU to patients with chemo-na ïve colorectal cancer is feasible and with low toxicity. A high response rate and long median overall survival were obtained. (Source: Oncology)
Source: Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Na ïve Patients with Liver Metastases from Colorectal Cancer.
CONCLUSIONS: Intrahepatic infusion of oxaliplatin in 10 min with systemic 5-FU to patients with chemo-naïve colorectal cancer is feasible and with low toxicity. A high response rate and long median overall survival were obtained. PMID: 30999314 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 18, 2019 Category: Cancer & Oncology Authors: Larsen FO, Jensen BV, Nørgaard HH, Hermann HK, Larsen PN, Markussen A, Hogdall E, Nielsen D Tags: Oncology Source Type: research

Advocacy for a New Oncology Research Paradigm: The Model of Bevacizumab in Triple-Negative Breast Cancer in a French Cohort Study
Conclusions: Beyond being the phoenix of breast oncology and a magnet of controversy, the case of bevacizumab in metastatic breast cancer highlights one of the greatest challenges in oncology, namely to balance modest clinical benefits with exponential costs. A balance needs to be found between health care affordability, high price of progress, and the best medical decision for the patients, in order to avoid the “unbreathable tipping point” we are actually dealing with.Oncology (Source: Oncology)
Source: Oncology - April 3, 2019 Category: Cancer & Oncology Source Type: research

Treatment-Induced Cardiotoxicity in Breast Cancer: A Review of the Interest of Practicing a Physical Activity
Physical activity is known to prevent the occurrence of cancer and decrease the risk of breast cancer. At diagnosis of breast cancer, fewer than half of the patients reach the international recommendation for physical activity. However, breast cancer patients, and particularly HER2+ breast cancer patients, are exposed to treatment-induced cardiotoxicity because of a side effect of 2 molecules used in standard therapy to treat these tumors, i.e., anthracycline and trastuzumab. Cardiotoxicity can sometimes lead to discontinuation of the treatment and even to the development of cardiovascular diseases. Exercise is known to pr...
Source: Oncology - April 3, 2019 Category: Cancer & Oncology Source Type: research

Treatment-Induced Cardiotoxicity in Breast Cancer: A Review of the Interest of Practicing a Physical Activity.
, Durando X Abstract Physical activity is known to prevent the occurrence of cancer and decrease the risk of breast cancer. At diagnosis of breast cancer, fewer than half of the patients reach the international recommendation for physical activity. However, breast cancer patients, and particularly HER2+ breast cancer patients, are exposed to treatment-induced cardiotoxicity because of a side effect of 2 molecules used in standard therapy to treat these tumors, i.e., anthracycline and trastuzumab. Cardiotoxicity can sometimes lead to discontinuation of the treatment and even to the development of cardiovascular dis...
Source: Oncology - April 3, 2019 Category: Cancer & Oncology Authors: Ginzac A, Passildas J, Gadéa E, Abrial C, Molnar I, Trésorier R, Duclos M, Thivat E, Durando X Tags: Oncology Source Type: research

Advocacy for a New Oncology Research Paradigm: The Model of Bevacizumab in Triple-Negative Breast Cancer in a French Cohort Study.
CONCLUSIONS: Beyond being the phoenix of breast oncology and a magnet of controversy, the case of bevacizumab in metastatic breast cancer highlights one of the greatest challenges in oncology, namely to balance modest clinical benefits with exponential costs. A balance needs to be found between health care affordability, high price of progress, and the best medical decision for the patients, in order to avoid the "unbreathable tipping point" we are actually dealing with. PMID: 30939479 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 2, 2019 Category: Cancer & Oncology Authors: Mery B, Rowinski E, Vallard A, Jacquin JP, Simoens X, Magné N, Doucey P Tags: Oncology Source Type: research

Association of Preoperative Platelet-to-Lymphocyte Ratio with Poor Outcome in Patients with Distal Cholangiocarcinoma
Conclusions: Preoperative PLR assessment may be useful for detecting high-risk DCC patients undergoing surgical resection for aggressive adjuvant therapy.Oncology (Source: Oncology)
Source: Oncology - March 31, 2019 Category: Cancer & Oncology Source Type: research

Nectin-1 Expression in Colorectal Cancer: Is There a Group of Patients with High Risk for Early Disease Recurrence?
Conclusion: Nectin-1 expression in colorectal cancer is associated with a significantly worse 3-year progression-free survival identifying therefore a group of patients with high risk for early disease recurrence.Oncology (Source: Oncology)
Source: Oncology - March 31, 2019 Category: Cancer & Oncology Source Type: research

Nectin-1 Expression in Colorectal Cancer: Is There a Group of Patients with High Risk for Early Disease Recurrence?
CONCLUSION: Nectin-1 expression in colorectal cancer is associated with a significantly worse 3-year progression-free survival identifying therefore a group of patients with high risk for early disease recurrence. PMID: 30917374 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 27, 2019 Category: Cancer & Oncology Authors: Tampakis A, Tampaki EC, Nonni A, Droeser R, Posabella A, Tsourouflis G, Kontzoglou K, Patsouris E, von Flüe M, Kouraklis G Tags: Oncology Source Type: research

Association of Preoperative Platelet-to-Lymphocyte Ratio with Poor Outcome in Patients with Distal Cholangiocarcinoma.
CONCLUSIONS: Preoperative PLR assessment may be useful for detecting high-risk DCC patients undergoing surgical resection for aggressive adjuvant therapy. PMID: 30909286 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 25, 2019 Category: Cancer & Oncology Authors: Hoshimoto S, Hishinuma S, Shirakawa H, Tomikawa M, Ozawa I, Ogata Y Tags: Oncology Source Type: research

Patterns of Failures and Clinical Outcome of Patients with Early-Stage, High-Risk, Node-Negative Endometrial Cancer Treated with Surgery Followed by Adjuvant Platinum-Based Chemotherapy and Vaginal Brachytherapy
Conclusions: This retrospective study appears to show that adjuvant platinum-based chemotherapy plus VBT achieve very good results in endometrioid carcinoma. This combined treatment seems to be less effective in nonendometrioid carcinoma.Oncology (Source: Oncology)
Source: Oncology - March 22, 2019 Category: Cancer & Oncology Source Type: research

Patterns of Failures and Clinical Outcome of Patients with Early-Stage, High-Risk, Node-Negative Endometrial Cancer Treated with Surgery Followed by Adjuvant Platinum-Based Chemotherapy and Vaginal Brachytherapy.
CONCLUSIONS: This retrospective study appears to show that adjuvant platinum-based chemotherapy plus VBT achieve very good results in endometrioid carcinoma. This combined treatment seems to be less effective in nonendometrioid carcinoma. PMID: 30904907 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 22, 2019 Category: Cancer & Oncology Authors: Laliscia C, Cosio S, Morganti R, Mazzotti V, Fabrini MG, Paiar F, Gadducci A Tags: Oncology Source Type: research

Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients
Conclusion: A higher pretreatment NLR was identified as a predictor of LN metastasis in endometrial cancers. Although further study is needed to confirm the results, NLR could be a candidate clinical marker for detection of LN metastasis.Oncology (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Source Type: research

Ramucirumab and Paclitaxel Administered Every 2 Weeks (mRAINBOW Regimen) in Advanced Gastroesophageal Adenocarcinoma
Conclusion: Biweekly administration of ramucirumab plus paclitaxel did not compromise efficacy. Delays, adjustments, or doses held were similar to the RAINBOW trial, with 31% requiring a dose or schedule modification.Oncology (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Source Type: research

Combination of Resection and Ablative Treatment for Hepatocellular Carcinoma: Usefulness of Complementary Radiofrequency Ablation
Conclusion: The combination of surgical resection and complementary RFA may be an effective strategy for treating HCC patients with countable multiple tumors, who are otherwise difficult to treat with surgical resection or RFA alone.Oncology (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Source Type: research

Trastuzumab Emtansine (T-DM1) Plus S-1 in Patients with Trastuzumab-Pretreated HER2-Positive Advanced or Metastatic Breast Cancer: A Phase Ib Study
Conclusions: S-1 can be safely combined with the clinically relevant dose of T-DM1 in patients with HER2-positive advanced or metastatic breast cancer. Further evaluation with a larger sample size is required for efficacy assessment.Oncology (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Source Type: research

Combination of Resection and Ablative Treatment for Hepatocellular Carcinoma: Usefulness of Complementary Radiofrequency Ablation.
CONCLUSION: The combination of surgical resection and complementary RFA may be an effective strategy for treating HCC patients with countable multiple tumors, who are otherwise difficult to treat with surgical resection or RFA alone. PMID: 30893698 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Authors: Hiraoka A, Hirooka M, Ochi H, Koizumi Y, Izumoto H, Ueki H, Tsuruta M, Ono A, Yoshino T, Aibiki T, Okudaira T, Yamago H, Suga Y, Iwasaki R, Mori K, Miyata H, Kishida M, Tsubouchi E, Abe M, Matsuura B, Ninomiya T, Joko K, Kawasaki H, Hiasa Y, Michitaka K Tags: Oncology Source Type: research

Trastuzumab Emtansine (T-DM1) Plus S-1 in Patients with Trastuzumab-Pretreated HER2-Positive Advanced or Metastatic Breast Cancer: A Phase Ib Study.
CONCLUSIONS: S-1 can be safely combined with the clinically relevant dose of T-DM1 in patients with HER2-positive advanced or metastatic breast cancer. Further evaluation with a larger sample size is required for efficacy assessment. PMID: 30893699 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Authors: Kojima Y, Yoshie R, Kawamoto H, Shimo A, Uejima T, Iwatani T, Motoyoshi A, Kanemaki Y, Boku N, Tsugawa K Tags: Oncology Source Type: research

Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients.
CONCLUSION: A higher pretreatment NLR was identified as a predictor of LN metastasis in endometrial cancers. Although further study is needed to confirm the results, NLR could be a candidate clinical marker for detection of LN metastasis. PMID: 30893700 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Authors: Aoyama T, Takano M, Miyamoto M, Yoshikawa T, Kato K, Sakamoto T, Takasaki K, Matsuura H, Soyama H, Hirata J, Suzuki A, Sasa H, Tsuda H, Furuya K Tags: Oncology Source Type: research

Ramucirumab and Paclitaxel Administered Every 2 Weeks (mRAINBOW Regimen) in Advanced Gastroesophageal Adenocarcinoma.
Abstract BACKGROUND: The RAINBOW trial established ramucirumab combined with paclitaxel as a second-line option in metastatic gastric and gastroesophageal junction (GEJ) adenocarcinoma. Ramucirumab was given on days 1 and 15 with paclitaxel on days 1, 8, and 15 of a 28-day cycle. The median overall survival (OS) was significantly longer with ramuciru-mab plus paclitaxel (p = 0.017), and it led to 41% grade 3 or higher neutropenia. We review our experience with both ramucirumab plus paclitaxel given biweekly (mRAINBOW) to assess efficacy and safety. OBJECTIVES: The primary objective was to assess OS. Secondary...
Source: Oncology - March 20, 2019 Category: Cancer & Oncology Authors: Rogers JE, Xiao L, Amlashi FG, Elimova E, Blum Murphy MA, Sanders E, Shanbhag N, Thomas I, Ajani JA Tags: Oncology Source Type: research

Risk of Pneumonitis with the Use of Different Immune Checkpoint Inhibitors in a Mexican Population
Conclusion: The incidence of pneumonitis secondary to treatment with PD-1 inhibitors in our Mexican population was 15%, which is 5 times higher than that found in other studies. No risk factor was identified for this increased incidence of drug-induced pneumonitis following the use of PD-1 inhibitors.Oncology (Source: Oncology)
Source: Oncology - March 14, 2019 Category: Cancer & Oncology Source Type: research

Risk of Pneumonitis with the Use of Different Immune Checkpoint Inhibitors in a Mexican Population.
CONCLUSION: The incidence of pneumonitis secondary to treatment with PD-1 inhibitors in our Mexican population was 15%, which is 5 times higher than that found in other studies. No risk factor was identified for this increased incidence of drug-induced pneumonitis following the use of PD-1 inhibitors. PMID: 30861515 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 12, 2019 Category: Cancer & Oncology Authors: Dávila-Dupont D, Motola-Kuba D, Dorantes-Heredia R, González-Alonso BK, Alcántara-Velarde T, García-Santisteban R, Martínez-Sámano JE, Grimaldo-Roque HJ, Ruiz-Morales JM Tags: Oncology Source Type: research

Dental Cone Beam Computed Tomography in Children: Clinical Effectiveness and Cancer Risk due to Radiation Exposure
Firstly used in the early 90s to generate 3-dimensional projections of X-ray images, cone beam computed tomography (CBCT) has resulted in a large application in dentomaxillofacial imaging, even in children. CBCT uses ionizing radiation that may cause damage to the DNA, and children are at the greatest carcinogenesis risk due to their higher tissue radiosensitivity and their longer life expectancy compared to adults. The questions of whether the cancer risk is really increased after repeated dental CBCT in childhood and of what the underlying biological basis is have become hot topics in the field of dentistry and radiobiol...
Source: Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

A Phase 2 Study of PCI-27483, a Factor VIIa Inhibitor in Combination with Gemcitabine for Advanced Pancreatic Cancer
Conclusions: Targeted inhibition of the coagulation cascade was achieved by administering PCI-27483. PCI-27483 –gemcitabine was well tolerated, but superiority to single agent gemcitabine was not demonstrated.Oncology 2019;96:1 –6 (Source: Oncology)
Source: Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

A Phase 2 Study of PCI-27483, a Factor VIIa Inhibitor in Combination with Gemcitabine for Advanced Pancreatic Cancer.
CONCLUSIONS: Targeted inhibition of the coagulation cascade was achieved by administering PCI-27483. PCI-27483-gemcitabine was well tolerated, but superiority to single agent gemcitabine was not demonstrated. PMID: 30844808 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 7, 2019 Category: Cancer & Oncology Authors: Ramanathan RK, Thomas GW, Khorana AA, Shah S, Zhou C, Wong S, Cole G, James D, Gabrail NY Tags: Oncology Source Type: research

Dental Cone Beam Computed Tomography in Children: Clinical Effectiveness and Cancer Risk due to Radiation Exposure.
Abstract Firstly used in the early 90s to generate 3-dimensional projections of X-ray images, cone beam computed tomography (CBCT) has resulted in a large application in dentomaxillofacial imaging, even in children. CBCT uses ionizing radiation that may cause damage to the DNA, and children are at the greatest carcinogenesis risk due to their higher tissue radiosensitivity and their longer life expectancy compared to adults. The questions of whether the cancer risk is really increased after repeated dental CBCT in childhood and of what the underlying biological basis is have become hot topics in the field of denti...
Source: Oncology - March 5, 2019 Category: Cancer & Oncology Authors: De Felice F, Di Carlo G, Saccucci M, Tombolini V, Polimeni A Tags: Oncology Source Type: research

Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer
Conclusions: Patients with mCRC treated using regorafenib who experienced severe HFSR showed better overall survival than patients without severe HFSR. Severe HFSR may offer an early surrogate marker for the efficacy of regorafenib in patients with mCRC.Oncology (Source: Oncology)
Source: Oncology - February 14, 2019 Category: Cancer & Oncology Source Type: research

Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer.
CONCLUSIONS: Patients with mCRC treated using regorafenib who experienced severe HFSR showed better overall survival than patients without severe HFSR. Severe HFSR may offer an early surrogate marker for the efficacy of regorafenib in patients with mCRC. PMID: 30763946 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 14, 2019 Category: Cancer & Oncology Authors: Kobayashi K, Kawakami K, Yokokawa T, Aoyama T, Suzuki K, Wakatsuki T, Suenaga M, Sato H, Sugiyama E, Yamaguchi K, Hama T Tags: Oncology Source Type: research

Erratum
Oncology (Source: Oncology)
Source: Oncology - February 8, 2019 Category: Cancer & Oncology Source Type: research

Potential of Liquid Biopsies for Breast Cancer Screening, Diagnosis, and Response to Treatment
Cancer therapy decisions are often made according to the histopathological-molecular profile of tumor tissue obtained from surgery or biopsy. It has been shown that tumor profiles change with time and treatment, and that tumor tissue is heterogeneous. Thus, other approaches that are easily accessible and less invasive than surgery or biopsy to monitor responses to treatment and predict relapses are urgently needed. In the last few years, the term “liquid biopsies” has been introduced to represent multifunctional circulating biomarkers in the peripheral blood and other physiological fluids of patients with cance...
Source: Oncology - January 17, 2019 Category: Cancer & Oncology Source Type: research

Potential of Liquid Biopsies for Breast Cancer Screening, Diagnosis, and Response to Treatment.
Abstract Cancer therapy decisions are often made according to the histopathological-molecular profile of tumor tissue obtained from surgery or biopsy. It has been shown that tumor profiles change with time and treatment, and that tumor tissue is heterogeneous. Thus, other approaches that are easily accessible and less invasive than surgery or biopsy to monitor responses to treatment and predict relapses are urgently needed. In the last few years, the term "liquid biopsies" has been introduced to represent multifunctional circulating biomarkers in the peripheral blood and other physiological fluids of pat...
Source: Oncology - January 17, 2019 Category: Cancer & Oncology Authors: Eigeliene N, Saarenheimo J, Jekunen A Tags: Oncology Source Type: research

Dose and Location of Irradiation Determine Survival for Patients with Hepatocellular Carcinoma with Macrovascular Invasion in External Beam Radiation Therapy
Conclusion: We conclude that a multidisciplinary therapeutic strategy based on EBRT should be proactively selected in the treatment of advanced HCC with MVI.Oncology (Source: Oncology)
Source: Oncology - January 16, 2019 Category: Cancer & Oncology Source Type: research

Dose and Location of Irradiation Determine Survival for Patients with Hepatocellular Carcinoma with Macrovascular Invasion in External Beam Radiation Therapy.
CONCLUSION: We conclude that a multidisciplinary therapeutic strategy based on EBRT should be proactively selected in the treatment of advanced HCC with MVI. PMID: 30650415 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - January 16, 2019 Category: Cancer & Oncology Authors: Iwamoto H, Nomiyama M, Niizeki T, Shimose S, Shirono T, Nakano M, Satani M, Okamura S, Noda Y, Kamachi N, Sakai M, Suzuki H, Kuromatsu R, Ogo E, Abe T, Tanaka M, Koga H, Torimura T Tags: Oncology Source Type: research

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer
Conclusions: Persistent fatigue at 1 year after EBRT in prostate cancer survivors is likely related to a cluster of symptoms elicited by chronic inflammation. Therapies that target each of these symptoms will likely reduce fatigue in this patient population.Oncology (Source: Oncology)
Source: Oncology - January 13, 2019 Category: Cancer & Oncology Source Type: research