A Fragile Balance: The Important Role of the Intestinal Microbiota in the Prevention and Management of Colorectal Cancer.
Abstract BACKGROUND: Colorectal cancer is the second leading cause of cancer-related death worldwide. In recent years, researchers have focussed on the role of the intestinal microbiota in both the prevention and the treatment of colorectal cancer. SUMMARY: The evidence in the literature supports that there is a fragile balance between different species of bacteria in the human gut. A disturbance of this balance towards increased levels of the bacteria Fusobacterium nucleatum and Bacteroides fragilis is associated with an increased risk of colorectal cancer. The mechanisms involved include the release of toxi...
Source: Oncology - June 30, 2020 Category: Cancer & Oncology Authors: Toumazi D, Constantinou C Tags: Oncology Source Type: research

Rechallenge Strategy in Cancer Therapy.
Abstract Drug resistance is one of the most important factors limiting the success of systemic anticancer therapy in achieving cure or prolonged overall survival. In clinical practice, resistant disease describes cancer that is found to have progressed since the time of treatment initiation. The term "drug resistant" is often used synonymously with "progressive disease" when referring to a treated tumour. Stopping a treatment at the time of disease progression is the current dominant approach of clinical trial conduct; therefore, available data from clinical trials are routinely not able to pro...
Source: Oncology - June 29, 2020 Category: Cancer & Oncology Authors: Hanovich E, Asmis T, Ong M, Stewart D Tags: Oncology Source Type: research

TUBB3 Is Associated with High-Grade Histology, Poor Prognosis, p53 Expression, and Cancer Stem Cell Markers in Clear Cell Renal Cell Carcinoma.
CONCLUSION: These results suggest that TUBB3 may play an oncogenic role and could be a potential therapeutic target in ccRCC. PMID: 32585672 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 25, 2020 Category: Cancer & Oncology Authors: Sekino Y, Han X, Babasaki T, Miyamoto S, Kitano H, Kobayashi G, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A Tags: Oncology Source Type: research

Clinical Characteristics of Metastatic Prostate Cancer Patients Infected with COVID-19 in South Italy.
Abstract BACKGROUND: To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS: We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at the Tortora Hospital, Pagani, Italy. RESULTS: Among 72 patients, 48 and 24 were hormone-sensitive (HS) and castration-resistant prostate cancer (CRPC), respectively; 0 HS and 2 (8.3%) CRPC (p
Source: Oncology - June 22, 2020 Category: Cancer & Oncology Authors: Di Lorenzo G, Buonerba L, Ingenito C, Crocetto F, Buonerba C, Libroia A, Sciarra A, Ragone G, Sanseverino R, Iaccarino S, Napodano G, Imbimbo C, Leo E, Kozlakidis Z, De Placido S Tags: Oncology Source Type: research

Tissue-Infiltrating Lymphocytes as a Predictive Factor for Recurrence in Patients with Curatively Resected Colon Cancer: A Propensity Score Matching Analysis.
CONCLUSIONS: In patients with curatively resected colon cancer, TILs in the invasive margin and CD8+ cell density in the central part may be prognostic factors suggesting host antitumor immune response. PMID: 32526753 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 11, 2020 Category: Cancer & Oncology Authors: Chan LF, Sadahiro S, Suzuki T, Okada K, Miyakita H, Yamamoto S, Kajiwara H Tags: Oncology Source Type: research

Treatment Outcome of Second-Line Chemotherapy for Gynecologic Carcinosarcoma.
CONCLUSION: The outcome of gynecologic carcinosarcoma in the second-line setting is poor, especially in patients with a short treatment-free interval. PMID: 32526764 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 11, 2020 Category: Cancer & Oncology Authors: Ebata T, Yonemori K, Nishikawa T, Sudo K, Shimomura A, Noguchi E, Fujiwara Y, Kato T, Hasegawa K, Fujiwara K, Tamura K Tags: Oncology Source Type: research

Pathogenic Germline Mutations in Chinese Patients with Gastric Cancer Identified by Next-Generation Sequencing.
CONCLUSIONS: Our study has depicted the spectrum of pathogenic germline mutations in Chinese GC patients, which may provide valuable clues for the assessment of the genetic susceptibility and clinical management in GC. PMID: 32521533 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 10, 2020 Category: Cancer & Oncology Authors: Zhou J, Zhao Z, Zhang Y, Bao C, Cui L, Cai S, Bai Y, Shen L, Zhang X Tags: Oncology Source Type: research

How Useful Are Tumor Markers in Detecting Metastases with FDG-PET/CT during Breast Cancer Surveillance?
Abstract BACKGROUND: To assess the clinical usefulness of serum tumor markers for early detection of distant breast cancer recurrence using FDG-PET/CT. METHODS: We retrospectively analyzed 561 consecutive patients who underwent surgery for invasive primary breast cancer and had increased tumor markers (CA 15-3 and CEA) after completion of locoregional therapy. FDG-PET/CT data were reviewed for all cases. CA 15-3 and CEA were evaluated both in a continuous and in a quartile (Q) distribution. The Wilcoxon rank-sum test and logistic regression models were used to evaluate the association between increased tumor ...
Source: Oncology - June 9, 2020 Category: Cancer & Oncology Authors: Corso G, Gilardi L, Girardi A, De Scalzi AM, Pagani G, Rossi EMC, Montagna G, Veronesi P, Pagan E, Bagnardi V, Grana CM Tags: Oncology Source Type: research

Clinical Outcome in Patients with Carcinoma of the Esophagogastric Junction Treated with Neoadjuvant Radiochemotherapy or Perioperative Chemotherapy: A Two-Center Retrospective Analysis.
Abstract BACKGROUND: Adenocarcinoma of the esophagogastric junction (AEG) is a rare but rising tumor entity in the Western world. Treatment is complex, as multimodality is key to optimal results. However, trials solely including AEG are rare, and the question if neoadjuvant radiochemotherapy (NRCT) or neoadjuvant/perioperative chemotherapy (NACT) is superior remains unanswered. PATIENTS AND METHODS: Patients with AEG I-III treated between October 2010 and August 2019 at the Ordensklinikum Linz or the Kepler University Hospital were identified either from a monitored tumor registry or by chart review. Time-to-...
Source: Oncology - June 9, 2020 Category: Cancer & Oncology Authors: Wundsam HV, Doleschal B, Prommer R, Venhoda C, Schmitt C, Petzer A, Metz-Gercek S, Rumpold H Tags: Oncology Source Type: research

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound.
CONCLUSION: In locally advanced cervical cancer patients, 2D/3D TV-US can be considered accurate in the evaluation of parametrial infiltration to assess the response to NACT. It could be included as a diagnostic method in the preoperative work-up of cervical cancer. PMID: 32492692 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 3, 2020 Category: Cancer & Oncology Authors: Perniola G, Fischetti M, Tomao F, Di Donato V, Palaia I, Santangelo G, Lecce F, Piccioni MG, Muzii L, Benedetti Panici P Tags: Oncology Source Type: research

Efficacy of a Newly Modified Short Hydration Method for Gemcitabine and Cisplatin Combination Chemotherapy in Patients with Urothelial Carcinoma.
CONCLUSION: Our m-shGC therapy has an acceptable AE profile compared with conventional therapy, with UC patients showing good physical activity. PMID: 32485713 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - June 2, 2020 Category: Cancer & Oncology Authors: Naiki T, Sugiyama Y, Tasaki Y, Iida K, Etani T, Hamamoto S, Nagai T, Nozaki S, Ando R, Kawai N, Yasui T Tags: Oncology Source Type: research

Oral S-1 with 24-h Infusion of Irinotecan plus Bevacizumab versus FOLFIRI plus Bevacizumab as First-Line Chemotherapy for Metastatic Colorectal Cancer: An Open-Label Randomized Phase II Trial.
CONCLUSIONS: Our results show that the 24h-SIRI/B regimen is an effective and reasonably well-tolerated regimen for the first-line treatment of mCRC. PMID: 32474564 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 29, 2020 Category: Cancer & Oncology Authors: Sadahiro S, Suzuki T, Okada K, Saito G, Miyakita H, Ogimi T, Chan LF, Kamei Y Tags: Oncology Source Type: research

The Impact of EGFR Mutation Status and Brain Metastasis for Non-Small Cell Lung Cancer Treated with Ramucirumab plus Docetaxel.
CONCLUSION: This study revealed that EGFR mutation status and BM might be predictive or prognostic factors for PFS. PMID: 32464632 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 28, 2020 Category: Cancer & Oncology Authors: Furuya N, Ito K, Sakaguchi T, Hida N, Kakinuma K, Morikawa K, Inoue T, Komase Y, Hataji O, Mineshita M Tags: Oncology Source Type: research

Cardiac Troponin I Predicts Elevated B-type Natriuretic Peptide in Patients Treated with Anthracycline-Containing Chemotherapy.
CONCLUSION: Elevated TnI was an independent predictor for the development of BNP increase. The different characteristics of TnI and BNP should be considered when managing patients treated with anthracycline-containing therapy. PMID: 32454480 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Oikawa M, Yoshihisa A, Yokokawa T, Misaka T, Yaegashi D, Miyata M, Nakazato K, Ishida T, Takeishi Y Tags: Oncology Source Type: research

Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion.
Abstract INTRODUCTION: Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE: Our aim was to clarify the efficacy and safety of sorafenib treatment in patients with unresectable advanced HCC with bile duct invasion. METHODS: One hundred and seventy-five patients with advanced HCC were enrolled in this study. We retrospectively compared the outcomes of sorafenib between patients without bile duct invasion [B (-) group, n = 165] and thos...
Source: Oncology - May 20, 2020 Category: Cancer & Oncology Authors: Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M Tags: Oncology Source Type: research

Sorafenib Inhibits Proliferation, Migration and Invasion of Breast Cancer Cells.
CONCLUSION: Thus, sorafenib has anti-cancer activity against breast cancer cells and could improve the survival of breast cancer patients by inhibiting their invasive and metastatic properties. PMID: 32434184 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 20, 2020 Category: Cancer & Oncology Authors: Dattachoudhury S, Sharma R, Kumar A, Jaganathan BG Tags: Oncology Source Type: research

Efficacy of Three-Drug Induction Chemotherapy Followed by Preoperative Chemoradiation in Patients with Localized Gastric Adenocarcinoma.
We report the effect of three-drug induction chemotherapy on a large cohort of localized GAC patients. METHODS: We identified 97 patients with localized GAC who received three-drug induction chemotherapy followed by preoperative chemoradiation therapy. We assessed various endpoints (overall survival [OS], recurrence-free survival [RFS], R0 resection and pCR rate). RESULTS: The median follow-up time was 3.5 years (range; 0.4-16.7). The induction chemotherapy regimen was a fluoropyrimidine and a platinum compound (cisplatin or oxaliplatin) with a taxane (docetaxel or paclitaxel) for 95% of patients. Seventy-three (...
Source: Oncology - May 20, 2020 Category: Cancer & Oncology Authors: Mizrak Kaya D, Nogueras González GM, Harada K, Blum Murphy MA, Lee JH, Bhutani MS, Weston B, Thomas I, Rogers JE, Das P, Badgwell BD, Ajani JA Tags: Oncology Source Type: research

Transketolase-Like Protein 1 and Glucose Transporter 1 in Gastric Cancer.
CONCLUSION: In conclusion, our study showed that positive expression of TKTL1 correlates with a poor prognosis in gastric cancer. PMID: 32434192 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 20, 2020 Category: Cancer & Oncology Authors: Ahopelto K, Laitinen A, Hagström J, Böckelman C, Haglund C Tags: Oncology Source Type: research

Response Rate and Prognostic Impact of Salvage Chemotherapy after Nivolumab in Patients with Advanced Gastric Cancer.
CONCLUSION: Our preliminary study indicates that nivolumab exposure may enhance subsequent chemosensitivity in patients with advanced gastric cancer. PMID: 32428899 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Arigami T, Matsushita D, Okubo K, Yanagita S, Ehi K, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Uenosono Y, Ishigami S, Natsugoe S Tags: Oncology Source Type: research

Insular Decision Criteria in Clinical Practice: Analysis of Decision-Making in Oncology.
CONCLUSION: Insular criteria are commonly used in clinical decision-making, yet, the individual decision makers may not be aware of them. With this analysis, we demonstrate the existence of insular criteria and their variety. In daily practice and clinical studies, awareness of insular criteria is important. PMID: 32428914 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Iseli T, Fischer GF, Panje CM, Glatzer M, Hundsberger T, Rothermundt C, Schmidt B, Sirén C, Plasswilm L, Putora PM Tags: Oncology Source Type: research

Increased Arterio-Portal Shunt Formation after Drug-Eluting Beads TACE for Hepatocellular Carcinoma.
Abstract BACKGROUND AND AIMS: Conventional transcatheter arterial chemoembolization (C-TACE) and drug-eluting bead (DEB)-based TACE are current treatments for hepatocellular carcinoma (HCC). We compared the therapeutic efficacies and adverse events of these methods in a single-center retrospective cohort study. METHODS: We enrolled 174 patients treated between January 2010 and October 2016; 98 and 76 underwent C-TACE and DEB-TACE, respectively, with 76 and 22 of the former group and 49 and 27 of the latter group classified as Child-Pugh class A and B, respectively. Therapeutic outcomes, progression-free survi...
Source: Oncology - May 18, 2020 Category: Cancer & Oncology Authors: Shimose S, Iwamoto H, Tanaka M, Niizeki T, Shirono T, Nakano M, Okamura S, Noda Y, Kamachi N, Sakai M, Suzuki H, Nomiyama M, Kuromatsu R, Koga H, Torimura T Tags: Oncology Source Type: research

Adenoid Cystic Carcinoma of Bartholin's Gland: What Is the Best Approach?
Abstract Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy. PMID: 32408297 [PubMed - as supplied ...
Source: Oncology - May 14, 2020 Category: Cancer & Oncology Authors: Barcellini A, Gadducci A, Laliscia C, Imparato S, Vitolo V, Preda L, Valvo F Tags: Oncology Source Type: research

Genomic Profiling of Stage II Colorectal Cancer Identifies Candidate Genes Associated with Recurrence-Free Survival, Tumor Location, and Differentiation Grade.
CONCLUSIONS: Taken together, we have demonstrated the utility of panel-based massive parallel sequencing to explore the pathogenesis of CRC stage II. We have identified promising candidate gene mutations associated with cancer recurrence, tumor location, and differentiation grade in patients with CRC stage II, which merit further investigation. PMID: 32408300 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 14, 2020 Category: Cancer & Oncology Authors: Dimberg J, Andersson RE, Haglund S Tags: Oncology Source Type: research

High EREG Expression Is Predictive of Better Outcomes in Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy.
Abstract BACKGROUND/AIM: A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clinical outcome stratification remain a great challenge. We aimed to find the potential biomarker to predict the effect of neoadjuvant CCRT on rectal cancer. METHODS: We identified epiregulin (EREG) as the most significant predictive marker for neoadjuvant CCRT response from the published rectal cancer transcriptome data set GSE35452. We collected 172 biopsy ...
Source: Oncology - May 14, 2020 Category: Cancer & Oncology Authors: Lin CY, Hsieh PL, Chou CL, Yang CC, Lee SW, Tian YF, Shiue YL, Li WS Tags: Oncology Source Type: research

Oncology Informatics: Status Quo and Outlook.
Abstract Oncology has undergone rapid progress, with emerging developments in areas including cancer stem cells, molecularly targeted therapies, genomic analyses, and individually tailored immunotherapy. These advances have expanded the tools available in the fight against cancer. Some of these have seen broad media coverage resulting in justified public attention. However, these achievements have only been possible due to rapid developments in the expanding field of biomedical informatics and information technology (IT). Artificial intelligence, radiomics, electronic health records, and electronic patient-reporte...
Source: Oncology - May 14, 2020 Category: Cancer & Oncology Authors: Putora PM, Baudis M, Beadle BM, El Naqa I, Giordano FA, Nicolay NH Tags: Oncology Source Type: research

Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer.
Abstract INTRODUCTION: Anti-programmed cell death 1 (PD-1) therapies have shown promising clinical activity against gastric cancer (GC). We evaluated the clinical significance of immune-related gene expression in GC tissues to better understand the tumor immune microenvironment. METHODS: PD-1, PD-1 ligand 1 (PD-L1) and CD8 mRNA levels and clinicopathological factors, including survival, were examined by quantitative RT-PCR in 155 GC patients who underwent surgery. PD-1 and PD-L1 expression in tumor tissue from 24 GC patients was investigated by immunohistochemical analysis. RESULTS: PD-1, PD-L1 and CD8 m...
Source: Oncology - May 7, 2020 Category: Cancer & Oncology Authors: Ito S, Masuda T, Noda M, Hu Q, Shimizu D, Kuroda Y, Eguchi H, Tobo T, Utsunomiya T, Mimori K Tags: Oncology Source Type: research

Dose Issues in Cancer Chemotherapy.
Abstract In this review, human methotrexate dosing regimens, as well as their relationship to data from in vitro cell culture and in vivo animal and human studies, are discussed. Low-dose, intermediate-dose, and high-dose therapies are covered. Since in vitro and in vivo screenings of potential cancer drugs are commonplace in the development of cancer chemotherapy, comparisons of the three criteria for effectiveness are important. PMID: 32369814 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - May 5, 2020 Category: Cancer & Oncology Authors: Rizvi SAA, Shahzad Y, Saleh AM, Muhammad N Tags: Oncology Source Type: research

Cardiovascular Toxicity in Cancer Patients Treated with Tyrosine Kinase Inhibitors: A Real-World Single-Center Experience.
CONCLUSIONS: Our study confirms that imatinib is a relatively safe drug, while it reveals that the latest-generation TKIs may cause a burden of cardiovascular complications. GLS and PWV allow detection of early signs of cardiac and vascular toxicity in oncohematologic patients treated with TKI, and their use is advisable. PMID: 32348984 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 29, 2020 Category: Cancer & Oncology Authors: Novo G, Di Lisi D, Bronte E, Macaione F, Accurso V, Badalamenti G, Rinaldi G, Siragusa S, Novo S, Russo A Tags: Oncology Source Type: research

Prognostic Value of the Neutrophil-Lymphocyte, Platelet-Lymphocyte, and Monocyte-Lymphocyte Ratios in Male Breast Cancer Patients.
CONCLUSIONS: The present results reveal that elevated MLRs (>0.30) and PLRs (>169.1) are associated with poor OS among male BC patients. Similarly, but insignificantly, an elevated NLR (>2.74) affected OS. PMID: 32344419 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 28, 2020 Category: Cancer & Oncology Authors: Huszno J, Kołosza Z, Mrochem-Kwarciak J, Zajusz A Tags: Oncology Source Type: research

Are Immunohistochemical Markers Useful in Phenotypic Gastric Cancer Classification?
Abstract To identify useful markers for prognostic and therapeutic purposes, The Cancer Genome Atlas (TCGA) provided a molecular classification of gastric cancers (GCs). Previous studies have used immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) to define immunophenotypic surrogate markers of the molecular alterations. Some critical issues concerning the correct definition of immunophenotypic groups have emerged in these studies that employed tissue microarrays (TMAs). We performed an immunophenotypic classification by evaluating MLH1, p53, HER2, E-cadherin, and Epstein-Barr virus (EBV) on t...
Source: Oncology - April 21, 2020 Category: Cancer & Oncology Authors: Di Pinto F, Armentano R, Arborea G, Schena N, Donghia R, Valentini AM Tags: Oncology Source Type: research

Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients.
CONCLUSIONS: We discovered 42 proteins whose levels differed significantly between stage II and III rectal cancer patients who did or did not receive PRT. This study shows that PRT, although localized to the pelvis, leads to measurable, tumor stage-specific changes in plasma protein expression. Future studies of plasma proteins should, when relevant, take this into account and be aware of the widespread effects that PRT has on the plasma proteome. PMID: 32294655 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 15, 2020 Category: Cancer & Oncology Authors: Holm M, Joenväärä S, Saraswat M, Tohmola T, Ristimäki A, Renkonen R, Haglund C Tags: Oncology Source Type: research

Polymorphisms in Glycolysis-Related Genes Are Associated with Clinical Outcomes of Paclitaxel-Cisplatin Chemotherapy in Non-Small Cell Lung Cancer.
CONCLUSION: This result suggests that the PFKL rs2073436C>G and GPI rs7248411C>G are useful for predicting the clinical outcome of first-line paclitaxel-cisplatin chemotherapy in NSCLC. PMID: 32252059 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - April 6, 2020 Category: Cancer & Oncology Authors: Choi SH, Jin CC, Do SK, Lee SY, Choi JE, Kang HG, Kim JH, Lee JH, Hong MJ, Lee WK, Jeong JY, Shin KM, Lee YH, Seo H, Yoo SS, Lee J, Cha SI, Kim CH, Park JY Tags: Oncology Source Type: research

A Validation Study for Recurrence Risk Stratification of Stage II Colon Cancer Using the 55-Gene Classifier.
Abstract INTRODUCTION: DNA microarrays, such as the consensus molecular subtype (CMS) classification using>600 genes, are used to predict cancer patient prognosis. We recently constructed a simple 55-gene classifier (55GC) system to risk stratify colon cancer (CC). OBJECTIVE: Here, we validate the 55GC specifically for stage II CC and compare it with CMS categories. METHODS: Tissue sections from 232 stage II CC patients who underwent curative surgery without adjuvant chemotherapy between 2009 and 2012 were subjected to DNA microarray analysis. RESULTS: Based on the 55GC, patients were classified ...
Source: Oncology - April 1, 2020 Category: Cancer & Oncology Authors: Shinto E, Oki E, Shimokawa M, Yamaguchi S, Ishiguro M, Morita M, Kusumoto T, Tomita N, Hashiguchi Y, Tanaka M, Ohnuma S, Tada S, Matsushima T, Hase K Tags: Oncology Source Type: research

Management and Outcomes of Newly Diagnosed Non-Small Cell Lung Cancer Patients with Brain Metastases: A Real-World Study in Japan.
This study investigated the current management and outcomes of newly diagnosed NSCLC patients with BM in Japanese clinical practice, focusing on their driver mutation status. PATIENTS AND METHODS: We enrolled newly diagnosed, treatment-naïve NSCLC patients with BM between January 2012 and December 2015 from 4 institutions in Japan. The medical records of each patient were retrospectively reviewed, and the treatment details and outcomes were evaluated. RESULTS: In total, 203 patients with BM were enrolled in this study and 73 (36%) were neurologically symptomatic. Regarding initial treatment, 110 patients (54...
Source: Oncology - March 27, 2020 Category: Cancer & Oncology Authors: Yoshida H, Kim YH, Iwatsubo S, Sakaguchi C, Sakamori Y, Nagai H, Ozasa H, Mio T, Hirai T Tags: Oncology Source Type: research

Impact of Age on Inflammation-Based Scores among Patients Diagnosed with Stage III Non-Small Cell Lung Cancer.
CONCLUSIONS: The baseline PNI, hemoglobin level, and lymphocyte count were lower among the older patients; furthermore, CRP was higher, possibly, because of a more prominent inflammatory status in older patients with lung cancer. No other immunological or nutritional analytical variables were different between the age groups. PMID: 32203963 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 23, 2020 Category: Cancer & Oncology Authors: Palomar-Abril V, Soria-Comes T, Tarazona Campos S, Martín Ureste M, Giner Bosch V, Maestu Maiques IC Tags: Oncology Source Type: research

Bullous Pemphigoid and Malignancy in Two Different Hospital Populations: A Retrospective Cohort Review.
CONCLUSIONS: Overall, we did not find an increased risk of malignancy in BP patients compared to controls, nor did we find a statistically differing rate of malignancy in BP patients from various socioeconomic and ethnic backgrounds. PMID: 32182611 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 17, 2020 Category: Cancer & Oncology Authors: Wright B, Halper K, Worswick S Tags: Oncology Source Type: research

Diabetes and Metformin Association with Recurrence Score in a Large Oncotype Database of Breast Cancer Patients.
CONCLUSIONS: We conclude that neither diabetes diagnosis nor metformin use is associated with a difference in oncotype RS in this population of diabetic patients. PMID: 32182614 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 17, 2020 Category: Cancer & Oncology Authors: Tharakan S, Zimmerman B, Ru M, Blanter J, Cascetta K, Tiersten A Tags: Oncology Source Type: research

Evaluation of Systemic Inflammatory Response and Nutritional Biomarkers as Predictive Factors in Patients with Recurrent Gastric Cancer.
CONCLUSIONS: A GPS of 1 or 2 and a high level of CA125 are independent predictors of a poorer prognosis in patients receiving chemotherapy for recurrent gastric cancer. PMID: 32182616 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 17, 2020 Category: Cancer & Oncology Authors: Namikawa T, Yokota K, Yamaguchi S, Iwabu J, Munekage M, Uemura S, Tsujii S, Maeda H, Kitagawa H, Kumon M, Kobayashi M, Hanazaki K Tags: Oncology Source Type: research

Prognostic Impact of Postoperative Complications following Salvage Esophagectomy for Esophageal Cancer after Definitive Chemoradiotherapy.
CONCLUSION: The occurrence of complications leads to a poor prognosis for patients with esophageal cancer after salvage esophagectomy. Prevention of postoperative complications and long-term postoperative general supportive care might be important for improving patients' prognosis. PMID: 32155643 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 10, 2020 Category: Cancer & Oncology Authors: Sugimura K, Miyata H, Shinno N, Ushigome H, Asukai K, Hara H, Hasegawa S, Yamada D, Yamamoto K, Haraguchi N, Nishimura J, Motoori M, Wada H, Takahashi H, Yasui M, Omori T, Ohue M, Yano M Tags: Oncology Source Type: research

Human Telomerase Reverse Transcriptase Gene Promoter Mutation in Serum of Patients with Hepatocellular Carcinoma.
CONCLUSIONS: The -124 bp G>A hTERT promoter mutation was observed in the serum of 69% of HCC patients who underwent surgical resection and was an independent predictor of disease progression in HCC. PMID: 32135540 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - March 5, 2020 Category: Cancer & Oncology Authors: Ako S, Nouso K, Kinugasa H, Matsushita H, Terasawa H, Adachi T, Wada N, Takeuchi Y, Mandai M, Onishi H, Ikeda F, Shiraha H, Takaki A, Fujioka S, Mimura T, Okada H Tags: Oncology Source Type: research

Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma.
We examined median survival time (MST) and time to progression (TTP) in all patients (n = 375), prognosis according to the O-PNI (high/low:>40/≤40) in 298 patients with lymphocyte findings, and the prognostic/predictive values of Child-Pugh stage, albumin-bilirubin (ALBI)/modified ALBI (mALBI) grade, and O-PNI for Chemotherapy grade (OPNIC grade 1/2/3: O-PNI>40/≤40 to>36/≤36). RESULTS: The MST and TTP were 16.6 and 8.0 months, respectively. The MST and TTP according to the O-PNI (>40/≤40) were "not reached" (NR)/12.4 months (p
Source: Oncology - February 25, 2020 Category: Cancer & Oncology Authors: Hiraoka A, Kumada T, Tada T, Fukunishi S, Atsukawa M, Hirooka M, Tsuji K, Ishikawa T, Takaguchi K, Kariyama K, Itobayashi E, Tajiri K, Shimada N, Shibata H, Ochi H, Kawata K, Toyoda H, Ohama H, Tsutsui A, Itokawa N, Hayama K, Arai T, Imai M, Nakamura S, M Tags: Oncology Source Type: research

Nivolumab in Combination with Irinotecan and 5-Fluorouracil (FOLFIRI) for Refractory Advanced Gastroesophageal Cancer.
CONCLUSION: In this small cohort of patients, we conclude that this combination is quite feasible and resulted in prolonged stability in some patients. Further development of this regimen is warranted. PMID: 32097933 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 25, 2020 Category: Cancer & Oncology Authors: Rogers JE, Xiao L, Trail A, Blum Murphy M, Palmer M, Ajani JA Tags: Oncology Source Type: research

High Serum OX40 and OX40 Ligand (OX40L) Levels Correlate with Reduced Survival in Patients with Advanced Lung Adenocarcinoma.
CONCLUSIONS: High OX40 and OX40L levels are associated with poor prognosis and may reflect the immune-exhausted status against lung adenocarcinoma. PMID: 32097938 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 25, 2020 Category: Cancer & Oncology Authors: Kashima J, Okuma Y, Hosomi Y, Hishima T Tags: Oncology Source Type: research

Hepatic Arterial Infusion Chemotherapy of 5-Fluorouracil for Patients with Unresectable Liver Metastases from Colorectal Cancer Refractory to Standard Systemic Chemotherapy: A Multicenter Retrospective Study.
CONCLUSIONS: There were few incidences of severe adverse events to HAIC of 5FU for liver metastases from CRC refractory to standard systemic chemotherapy. Therefore, it might present as a treatment option as last-line chemotherapy. PMID: 32092755 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 24, 2020 Category: Cancer & Oncology Authors: Sato Y, Inaba Y, Aramaki T, Sone M, Morita Y, Nishiofuku H, Tanaka T, Miyazaki M, Matsueda K, Arai Y Tags: Oncology Source Type: research

Systemic Antitumor Effects and Abscopal Responses in Melanoma Patients Receiving Radiation Therapy.
CONCLUSIONS: Current clinical evidence suggests that there is a large potential to enhance the abscopal effect when radiation therapy is combined with immunotherapeutic agents for the treatment of malignant melanoma. Ongoing and planned clinical trials may provide us with a more in-depth understanding of how this combination therapy can be optimally utilized clinically to achieve improved survival outcomes among patients with malignant melanoma. PMID: 32079015 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 20, 2020 Category: Cancer & Oncology Authors: D'Andrea MA, Reddy GK Tags: Oncology Source Type: research

Indication and Prognostic Significance of Conversion Surgery in Patients with Liver Metastasis from Gastric Cancer.
Abstract OBJECTIVE: Chemotherapy is generally recommended as the first-line standard treatment in patients with liver metastasis from gastric cancer. However, the clinical impact of surgical treatment remains unclear in responders after chemotherapy. The present study aimed to investigate the tumor response and prognosis after chemotherapy and to assess the clinical indication of conversion surgery in responders. METHODS: The study retrospectively reviewed the clinical data of 44 patients with liver metastasis from gastric cancer who were treated with chemotherapy between February 2002 and January 2019. These...
Source: Oncology - February 14, 2020 Category: Cancer & Oncology Authors: Arigami T, Matsushita D, Okubo K, Kawasaki Y, Iino S, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Maemura K, Yanagita S, Uenosono Y, Ishigami S, Natsugoe S Tags: Oncology Source Type: research

Expression of Receptor Tyrosine Kinases on Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes in Patients with Renal Cell Carcinoma and Healthy Donors.
Abstract BACKGROUND: Very little is known about receptor tyrosine kinase (RTK) expression on peripheral blood mononuclear cells (PBMC) in humans including renal cell carcinoma (RCC) patients. OBJECTIVES: The primary objective of this study was to evaluate expression levels of major RTKs on PBMC and tumor-infiltrating lymphocytes (TIL) isolated from RCC patients. The secondary aim was to compare levels of RTK expression in RCC patients before surgery and on the 180th day after surgery (lymphocyte lifetime) and to compare them with the expression in healthy donors. In addition, we compared RTK and PD-L1 express...
Source: Oncology - February 13, 2020 Category: Cancer & Oncology Authors: Tsimafeyeu I, Volkova M, Olshanskaia A, Raskin G, Aschuba S, Khochenkova Y, Bondarenko A, Khochenkov D Tags: Oncology Source Type: research

Art Therapy Sessions for Cancer Patients: A Single-Centre Experience.
CONCLUSIONS: Art therapy sessions had an impact on patients' welfare. We also reported a trend towards amelioration of quality of life that could probably be confirmed in a larger population, and potentially with a different methodology. PMID: 32045903 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - February 11, 2020 Category: Cancer & Oncology Authors: Gras M, Daguenet E, Brosse C, Beneton A, Morisson S Tags: Oncology Source Type: research

"Logic-Based Medicine" Is More Feasible than "Evidence-Based Medicine" in the Local Treatment for Hepatocellular Carcinoma.
"Logic-Based Medicine" Is More Feasible than "Evidence-Based Medicine" in the Local Treatment for Hepatocellular Carcinoma. Oncology. 2020 Feb 11;:1-8 Authors: Sakon M, Kobayashi S, Wada H, Eguchi H, Marubashi S, Takahashi H, Akita H, Gotoh K, Yamada D, Asukai K, Hasegawa S, Ohue M, Yano M, Nagano H Abstract The optimal type of surgery (e.g., anatomic or non-anatomic resection) or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is still under debate despite numerous comparative studies based on overall survival. This debate continues not only because these endpoint...
Source: Oncology - February 11, 2020 Category: Cancer & Oncology Authors: Sakon M, Kobayashi S, Wada H, Eguchi H, Marubashi S, Takahashi H, Akita H, Gotoh K, Yamada D, Asukai K, Hasegawa S, Ohue M, Yano M, Nagano H Tags: Oncology Source Type: research

The Five-Year Survival Rate of Patients with Nasopharyngeal Carcinoma Based on Tumor Response after Receiving Neoadjuvant Chemotherapy, Followed by Chemoradiation, in Indonesia: A Retrospective Study.
Abstract INTRODUCTION: Nasopharyngeal cancer (NPC) is a common malignancy in Southeast Asia with a high mortality rate. Previous studies have shown that the patient survival rate is
Source: Oncology - January 27, 2020 Category: Cancer & Oncology Authors: Dwijayanti F, Prabawa A, Besral, Herawati C Tags: Oncology Source Type: research