Target Fishing of Calactin, Calotropin and Calotoxin Using Reverse Pharmacophore Screening and Consensus Inverse Docking Approach.
CONCLUSION: The results of this study confirmed ITK as a potential target for calactin, calotropin and calotoxin. These compounds can therefore be used as lead molecules for the development of novel ITK inhibitors, which may have immense therapeutic applications as immune-suppressants and as anticancer drugs. PMID: 33292137 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 7, 2020 Category: Drugs & Pharmacology Authors: Parthasarathy V, Menon AR, Devaranavadagi B Tags: Curr Drug Discov Technol Source Type: research

Micro-RNA (miRNA): A biomarker to identify novel compounds in drug discovery and delivery for cancer therapy.
Abstract Micro-RNAs (miRNA) are short non-coding sequences involved in the biological regulatory process. The miRNA shows a unique expression in diseases resulting in the pathogenesis. Identifying the novel compounds are interesting during this process. The miRNA is a biomarker that helps to find the early stage of cancer disease through pathogenesis. Azobenzene and pyrazole are the novel compounds having a cytotoxic effect on cancer cells. These novel compounds are molecular probe used in breast cancer therapy. The viral-based systems have few limitations such as toxicity and immunogenicity. So, the non-viral bas...
Source: Current Drug Discovery Technologies - November 16, 2020 Category: Drugs & Pharmacology Authors: Paramasivam G Tags: Curr Drug Discov Technol Source Type: research

A New Approach against Some Oral Pathogenic Bacteria Using a Chimeric Antimicrobial Peptide Derived from the Camel Milk; Lactoferrampin - Lactoferricin Chimer.
CONCLUSION: The LFA-LFC chimer revealed comparable or even more effective antibacterial properties compared to the chlorhexidine against the caries-inducing bacteria with no toxicity on the human gingival fibroblast cells. So, this peptide can be used as a safe alternative to the chlorhexidine and other chemicals in the dental applications for prevention and management of the dental caries. PMID: 33183206 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 11, 2020 Category: Drugs & Pharmacology Authors: Mohammadipour HS, Akbari M, Tanhaeian A, Pourgonabadi S, Sekandari S, Karimian E Tags: Curr Drug Discov Technol Source Type: research

Design, Synthesis and Biological Evaluation of Novel Heterocyclic Fluoroquinolone Citrate Conjugates as Potential Inhibitors of Topoisomerase IV: A Computational Molecular Modeling Studies.
CONCLUSION: The present work, through simple synthetic approaches, led to the development of novel hybrids of fluoroquinolone containing citrate-triazole-oxadiazole pharmacophores that exhibited remarkable biological activities against different microorganisms and cell line. The compounds showed suitable drug like properties and are expected to present good bioavailability profile. An efficient combination of molecular modeling and biological activity provided an insight into QSAR guide lines that could aid in further development and optimization of the norfloxacin derivatives. PMID: 33155923 [PubMed - as supplied by ...
Source: Current Drug Discovery Technologies - November 6, 2020 Category: Drugs & Pharmacology Authors: Allaka TR, Katari NK, Jonnalagadda SB, Malkhed V, Anireddy JS Tags: Curr Drug Discov Technol Source Type: research

Molecular modelling studies on thiazole-based α-Glucosidase Inhibitor using docking and CoMFA, CoMSIA and HQSAR.
CONCLUSION: The HQSAR model of training set exhibits significant cross-validated correlation coefficient q2 0.800 and noncross-validated correlation coefficient r2 0.943. PMID: 33092511 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 22, 2020 Category: Drugs & Pharmacology Authors: Joshi D, Yadav S, Sharma R, Pandya M, Bhadauria RS Tags: Curr Drug Discov Technol Source Type: research

The Effects of Herbal Medicines on Women Sexual Dysfunction: A Systematic Review.
This study aimed to the evaluation of the studies focusing on the herbal medicine on women sexual function and the assessment of its effectiveness. PMID: 33076811 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 19, 2020 Category: Drugs & Pharmacology Authors: Molkara T, Motavasselian M, Akhlaghi F, Ramezani MA, Naghedi Baghdar H, Ghazanfari SM, Salari R Tags: Curr Drug Discov Technol Source Type: research

A Comparative Survey on Antioxidant Activity of Iranian Shrimp Waste [Penaeus Semisulcatus] and Synthetic Antioxidants.
Abstract Shrimp waste, as an important source of natural carotenoids, is produced in large quantities in seafood processing industry. One of the important characteristics of carotenoids is their ability to act as antioxidants, thus protecting cells and tissues from damaging effects of free radicals and singlet oxygen. The aim of this study was to find effective method for carotenoid extraction [Enzymatic and alkaline treatment] from shrimp waste and compare their antioxidant potential with synthetic antioxidants butylated hydroxyanisole [BHA] and butylated hydroxytoluene [BHT] using sunflower oil. The sunflower oi...
Source: Current Drug Discovery Technologies - October 6, 2020 Category: Drugs & Pharmacology Authors: Saatloo NV, Peivasteh-Roudsari L, Gharehgheshlaghi HE, Khaniki GJ, Nodehi RN, Alimohammadi M, Sadighara P Tags: Curr Drug Discov Technol Source Type: research

Efficacy of Six Plants of Apiaceae Family for Body Weight Management: A Review from the Perspective of Modern and Traditional Persian Medicine.
CONCLUSION: Since the TPM is a rich source of information about the medicinal properties and effects of medicinal plants, investigating the therapeutic effects of plants from the perspective of TPM can represents the vision of a new horizon in the treatment of many diseases. PMID: 33023434 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 6, 2020 Category: Drugs & Pharmacology Authors: Rameshk M, Kalantari-Khandani S Tags: Curr Drug Discov Technol Source Type: research

Closing the gap: an atomistic structural and functional perspective of S. mansoni universal stress G4LZI3 protein in complex with phenolic compounds.
CONCLUSION: This study therefore, implemented the use of molecular dynamic (MD) simulations to provide functional and structural insight into key conformational changes upon binding of G4ZLI3 to these key phenolic compounds. Post-MD analyses revealed unique structural and conformational changes in the G4LZI3 protein in complex with curcumin and catechin respectively. These systems exhibited the highest binding energies, while the major interacting residues conserved in all the complexes provides a route map for structure-based drug design of novel compounds with enhanced inhibitory potency against the G4LZI3 protein. This ...
Source: Current Drug Discovery Technologies - September 30, 2020 Category: Drugs & Pharmacology Authors: Masamba P, Munsamy G, Kappo AP Tags: Curr Drug Discov Technol Source Type: research

Preparation and evaluation of possible antioxidant activities of Rose traditional tablet"[Qurs-e-Vard]" a selected Traditional Persian Medicine [TPM] formulation via various procedures.
CONCLUSION: Our findings indicated that this polyherbal formulation and its components have justifiable antioxidant effects. PMID: 32990537 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 28, 2020 Category: Drugs & Pharmacology Authors: Talebi M, Zarshenas MM, Yazdani E, Moein M Tags: Curr Drug Discov Technol Source Type: research

Synthesis and Study of Some 17a-aza-D-homo Steroids as 5 α-Reductase Inhibitors.
CONCLUSION: Compound6 showed immense potential with improved efficacy and better bioavailability, thus makes it a suitable candidate for further studies and optimal formulation. PMID: 32962621 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 21, 2020 Category: Drugs & Pharmacology Authors: Rana P, Dhingra N, Arora P, Dhingra R, Chauhan M, Gupta A Tags: Curr Drug Discov Technol Source Type: research

Bronchospasmolytic and Adenosine Binding Activity of 8- (Proline / Pyrazole)-Substituted Xanthine Derivatives.
CONCLUSION: Newly synthesized proline/pyrazole based xanthines compounds showed a satisfactory binding affinity for adenosine receptor subtypes. Replacement or variation of substituted proline ring with substituted pyrazole scaffold at 8thposition of xanthine moiety resulted in the reduction of adenosine binding affinity and bronchospasmolytic effects. PMID: 32962622 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 21, 2020 Category: Drugs & Pharmacology Authors: Singh S, Ojha M, Yadav D, Kachler S, Klotz KN, Yadav R Tags: Curr Drug Discov Technol Source Type: research

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000].
CONCLUSIONS: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients. PMID: 32964823 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 16, 2020 Category: Drugs & Pharmacology Authors: Nikouei Moghaddam MR, Movahedi M, Bananej M, Najafi S, Moghadam NB, Saadat P, Mokhtarian F, Mirshafiey A Tags: Curr Drug Discov Technol Source Type: research

Acute & Sub-Acute toxicity studies and Pharmacodynamic studies of standardized extract of Trachyspermum ammi (L.) Sprague (Fruits) against chemically induced inflammation in rats.
CONCLUSION: The spectroscopic and pharmacognostic analysis has shown the strong presence of flavonoids, mineral matter, protein, phenols, saponins, carbohydrates, volatile oils, fiber, glycosides and fat. Spectroscopic study interpretations have shown the presence of compounds like thymol, para-cymene, γ-terpinene, α- and β-pinene, carvone, limonene, saponins, , β-phellendrene, βfenchyl alcohol, α-thujene, β-phellendrene, α-thujene etc. No signs of toxicity were recorded during acute and sub-acute toxicity studies by noting the relative weight and histopathological analysis. A si...
Source: Current Drug Discovery Technologies - September 16, 2020 Category: Drugs & Pharmacology Authors: Saraswat N, Sachan N, Chandra P Tags: Curr Drug Discov Technol Source Type: research

Identification of Main Protease of Coronavirus SARS-CoV-2 (Mpro)Inhibitors from Melissa officinalis.
CONCLUSION: Salvanolic acid A can be further evaluated as potential Mpro inhibitor. PMID: 32957889 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 16, 2020 Category: Drugs & Pharmacology Authors: Elekofehinti OO, Iwaloye O, Famusiwa CD, Akinseye O, Rocha JBT Tags: Curr Drug Discov Technol Source Type: research

Discovery and Development of New Anti-infectives: Perspectives and Prospective.
PMID: 32907529 [PubMed - in process] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 12, 2020 Category: Drugs & Pharmacology Authors: Kothari V Tags: Curr Drug Discov Technol Source Type: research

Extraction, Chemical Composition, Antioxidant Property and In vitro Anticancer Activity of Silymarin from Silybum Marianum On Kb and A549 Cell Lines.
CONCLUSION: Due to the good antioxidant and anticancer properties of the isolated silymarin, its use as an anticancer drug is suggested. PMID: 32860361 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 26, 2020 Category: Drugs & Pharmacology Authors: Azadpour M, Farajollahi MM, Varzi AM, Hashemzadeh P, Mahmoudvand H, Barati M Tags: Curr Drug Discov Technol Source Type: research

A New Series Of 1,3-Dimethylxanthine Based Adenosine A2a Receptor Antagonists As A Non-Dopaminergic Treatment Of Parkinson's Disease.
CONCLUSION: A new series of 7-substituted 8-m/p-chloropropoxyphenylxanthines having good affinity for A2A AR and potent antiparkinsonian activity has been developed. PMID: 32860362 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 26, 2020 Category: Drugs & Pharmacology Authors: Rohilla S, Bansal R, Chauhan P, Kachler S, Klotz KN Tags: Curr Drug Discov Technol Source Type: research

In Vitro and Ex Vivo Evaluation of Capparis Spinosa Extract to Inactivate Protoscoleces During Hydatid cyst Surgery.
CONCLUSION: The obtained results in vitro and ex vivo exhibited that potent protoscolicidal effects of C. spinosa extract particu-larly at the concentrations of 600 and 300 mg/ml which entirely eliminates the parasite after 5-20 min exposure. However, more and supplementary works are required to verify these findings through assessing in animal models and clinical subjects. PMID: 32814534 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 17, 2020 Category: Drugs & Pharmacology Authors: Mahmoudvand H, Khalaf AK, Beyranvand M Tags: Curr Drug Discov Technol Source Type: research

Anti-cancer effect of Urginea maritima bulb extract invitro through cell cycle arrest and induction of apoptosis in human breast cancer cell lines.
Abstract BACKGROUND: Breast cancer is the most common known malignancy in women and it is therefore very important to prevent and treat this cancer. In this experimental study, the anti-breast cancer effect of Urginea matrima was investigated. METHOD: Breast cancer cell lines [MCF-7 and MDA-MB231] and L929 normal cells [as a control group] were cultivated in DMEM medium. Bulb aqueous and hydroalcoholic extracts [70:30] were prepared through maceration method. The cultured cells were treated with different concentrations [6, 3, 1.5, 0.75, 0.375, 0.187 and 0.093 μg/mL] of U.maritima extracts for 24, 48 and 7...
Source: Current Drug Discovery Technologies - August 16, 2020 Category: Drugs & Pharmacology Authors: Saket K, Salari R, Saburi E, Yousefi M, Khodadoust MA, Hadi M, Afshari JT Tags: Curr Drug Discov Technol Source Type: research

Insights into Machine Learning-based approaches for Virtual Screening in Drug Discovery: Existing strategies and streamlining through FP-CADD.
CONCLUSIONS: By this thorough study, we have observed that in LBVS algorithms, Support vector machines (SVM) and Random forest (RF) are those which are widely used due to high accuracy and efficiency. These virtual screening approaches have the potential to revolutionize the drug designing field. Also, we believe that the process flow presented in this study, named FP-CADD, can streamline the whole process of computer-aided drug discovery. By adopting this rule, the studies related to drug discovery can be made homogeneous and this protocol can also be considered as an evaluation criterion in the peer-review process of res...
Source: Current Drug Discovery Technologies - August 5, 2020 Category: Drugs & Pharmacology Authors: Hussain W, Rasool N, Khan YD Tags: Curr Drug Discov Technol Source Type: research

Molecular context of ADP-ribosylation in schistosomes for drug discovery and vaccine development.
Abstract Schistosome infection is regarded as one of the most important and neglected tropical diseases associated with poor sanitation. Like other living organisms, schistosomes employ multiple biological processes, of which some are regulated by a post-translational modification called Adenosine diphosphate-ribosylation (ADP-ribosylation), catalyzed by ADPribosyltransferases. ADP-ribosylation is the addition of ADP-ribose moieties from nicotinamide adenine dinucleotide (NAD+) to various targets, which include proteins and nucleotides. It is crucial in biological processes such as DNA repair, apoptosis, carbohydr...
Source: Current Drug Discovery Technologies - August 5, 2020 Category: Drugs & Pharmacology Authors: Chutshela A, Masamba P, Oyinloye BE, Kappo AP Tags: Curr Drug Discov Technol Source Type: research

Discovery of traditional Chinese medicine derived compounds as wild type and mutant Plasmodium falciparum dihydrofolate reductase inhibitors: Induced fit docking and ADME studies.
CONCLUSION: The outcome of the present study should further be investigated to attest the efficacy of these compounds as better drug candidates than the antifolates. PMID: 32729419 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 28, 2020 Category: Drugs & Pharmacology Authors: Iwaloye O, Elekofehinti OO, Kikiowo B, Fadipe TM, Akinjiyan MO, Ariyo EO, Aiyeku OO, Adewumi NA Tags: Curr Drug Discov Technol Source Type: research

In-vitro bactericidal activity of a novel plant source Plumeria pudica against some human and fish pathogenic bacteria.
CONCLUSION: Leaf extracts of P. pudica contain bioactive compounds that can be used as broad spectrum bactericidal agent. PMID: 32718293 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 25, 2020 Category: Drugs & Pharmacology Authors: Das S, Burman S, Chandra G Tags: Curr Drug Discov Technol Source Type: research

Study Of Coleus Amboinicus Extract in Increasing of Transforming Growth Factor- β1 (TGF-β1) Concentration and Docking Prediction Quercetin Derivatives in 4X0M Receptor on Uric Acid-Induced in Rats.
CONCLUSION: CA extract is proven to inhibit acute renal failure by increasing of TGF-β1concentration and has strong binding of its receptor. PMID: 32703137 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 21, 2020 Category: Drugs & Pharmacology Authors: Solfaine R, Muniroh L, Hamid IS Tags: Curr Drug Discov Technol Source Type: research

Potential Fatty Acid as Antibacterial Agent against Oral Bacteria of Streptococcus mutans and Streptococcus sanguinis from Basil (Ocimum americanum): In vitro and in silico studies.
CONCLUSION: The lauric acid has potency as a new natural antibacterial agent through the MurA inhibition in bacterial cell wall biosynthesis. PMID: 32652913 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 11, 2020 Category: Drugs & Pharmacology Authors: Herdiyati Y, Astrid Y, Shadrina AAN, Wiani I, Satari MH, Kurnia D Tags: Curr Drug Discov Technol Source Type: research

The Effect of Myrtus communis Aqueous Extract-Containing Gel on Wound Healing in Streptozotocin-Induced Diabetic Rats.
CONCLUSION: These results demonstrate that aqueous extract of myrtle possesses a definite wound healing potential in diabetic condition. Our present findings may suggest the use of topical myrtle berries aqueous extract gel 6% to treat and manage intractable diabetic wounds. PMID: 32652914 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 11, 2020 Category: Drugs & Pharmacology Authors: Khodaie SA, Emadi F, Naseri M, Kamalinejad M, Riahi SM, Alijaniha F, Roghani M Tags: Curr Drug Discov Technol Source Type: research

In Silico Investigation of the SARS CoV2 Protease with Thymoquinone Major Constituent of Nigella Sativa.
Abstract The COVID-19 caused by a new type of coronavirus has emerged from China and led to thousands of deaths globally. Despite many groups engaged in studying the newly emerged virus and searching for the treatment, the understanding of the SARS-CoV2 target ligand interactions represents a key challenge. Several studies are being conducted to identify potential treatment. Alternatively, the results of numerous studies have shown that protease inhibitors can be a genuine leader in research. The antiviral activity and beneficial effect against respiratory disorders of thymoquinone have been largely demonstrated. ...
Source: Current Drug Discovery Technologies - July 11, 2020 Category: Drugs & Pharmacology Authors: Kadil Y, Mouhcine M, Filali H Tags: Curr Drug Discov Technol Source Type: research

A Concise overview of phytochemistry, pharmacology and clinical aspects of Persian Cumin; Bunium persicum (Boiss.) B.Fedtsch.
Abstract Bunium persicum is one of the most medically and economically important species of Apiaceae family. Despite variety of phytochemical and experimental research on this species, there is no considerable update on all related outcomes. Accordingly, current work compiles an overview on Cumin's phytochemical and pharmacological activities. Papers related to phytochemistry, pharmacology and clinical properties of B. persicum were filtered from databases as PubMed, ScienceDirect and Scopus with the term "Bunium persicum" till 15th May 2020. Genetic, pure pharmaceutical and agriculture papers were exclu...
Source: Current Drug Discovery Technologies - July 11, 2020 Category: Drugs & Pharmacology Authors: Mehrabadi MM, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

The Toxicity Effect of Echium Amoenum on the Liver and Kidney of Mice.
CONCLUSION: According to the present findings, it is suggested that Echium amoenum causes hepatotoxicity and nephrotoxicity effects in dose and time dependent manner. PMID: 32652917 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 11, 2020 Category: Drugs & Pharmacology Authors: Ghorbani M, Araghi A, Shariatifar N, Mirbaha SH, Abbasabadi BM, Samarghandian S, Farkhondeh T, Sadighara P Tags: Curr Drug Discov Technol Source Type: research

Inhibitory Effect of Artemisinin on Testosterone Propionate Induced Benign Prostatic Hyperplasia.
CONCLUSION: The present study concludes that the Artemisinin is efficacious in testosterone propionate induced BPH. This could be attributed, at least partly, to its anti-inflammatory property or its role in testosterone level reduction or as a Vitamin D receptor modulator. PMID: 32532194 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 11, 2020 Category: Drugs & Pharmacology Authors: Solanki A, Patel S, Solanki N, Shah U Tags: Curr Drug Discov Technol Source Type: research

Persian herbal medicine in functional dyspepsia: a systematic review article.
CONCLUSION: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD. PMID: 32525777 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 10, 2020 Category: Drugs & Pharmacology Authors: Azimi M, Zahedi MJ Tags: Curr Drug Discov Technol Source Type: research

Anti-Candida activity of Curcumin: A review.
Abstract Curcumin is one of the important natural compounds that is extracted from turmeric. This compound and its derivatives have numerous biological properties, including antioxidant, anticancer, anti-inflammatory, antimicrobial and healing effects. Extensive research in various fields has been conducted on turmeric as it is widely used as a food additive. The significant antifungal activity is one of the major effects of curcumin. In this paper, recent studies on the effects of different forms of curcumin drug on the candidiasis were systematically examined and discussed. The data in this study were extracted ...
Source: Current Drug Discovery Technologies - May 16, 2020 Category: Drugs & Pharmacology Authors: Cheraghipour K, Ezatpour B, Masoori L, Marzban A, Sepahvand A, Rouzbahani AK, Moridnia A, Khanizadeh S, Mahmoudvand H Tags: Curr Drug Discov Technol Source Type: research

Immunomodulatory effects of medicinal plants used for vitiligo in traditional Persian medicine..
CONCLUSION: According to scientific evidence on immunomodulatory effects, new research into the effects of these plants on vitiligo can lead to the discovery of new drugs and approaches for treating this disease. PMID: 32416680 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - May 16, 2020 Category: Drugs & Pharmacology Authors: Ebrahimabadi MH, Lamardi SNS, Shirbeigi L Tags: Curr Drug Discov Technol Source Type: research

Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent; a Comprehensive Review on Related Investigations.
CONCLUSION: Taken together, botanical parts of P. granatum have possessed notable radical scavenging and antimicrobial activities that with these properties, this plant can be introduced as a natural safe source of preservative and antioxidant. Accordingly, P. granatum can be applied as excipient with the aforementioned properties in the pharmaceutical and food industries. PMID: 32351184 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 28, 2020 Category: Drugs & Pharmacology Authors: Jalali A, Kiafar M, Seddigh M, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

In sillico analysis, synthesis, and biological evaluation of triazole derivatives as a H1 receptor antagonist.
CONCLUSION: Finally, these derivatives were screened for H1 receptor antagonist activity using guinea pig ileum taking chlorpheniramine maleate as a standard. Most of the compounds possesses better antihistamine activity. PMID: 32316895 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 19, 2020 Category: Drugs & Pharmacology Authors: Badeliya SN, Panchal II, Panigrahi B, Patel CN Tags: Curr Drug Discov Technol Source Type: research

Identifying the molecular targets of an anti-pathogenic hydroalcoholic extract of Punica granatum peel against multidrug resistant Serratia marcescens.
CONCLUSION: PGPE's anti-virulence effect against S. marcescens is multifaceted, affecting stress-response machinery, efflux activity, iron homeostasis, and cellular energetics of this bacterium notably. Among the major molecular targets identified in this study are LPS export transporter permease (LptF), t-RNA pseudouridine synthase (TruB), etc. PMID: 32316896 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 19, 2020 Category: Drugs & Pharmacology Authors: Joshi C, Patel P, Godatwar P, Sharma S, Kothari V Tags: Curr Drug Discov Technol Source Type: research

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine.
CONCLUSION: In addition to advantageous effects of antitussive herbs noted by TPM, the present review highlighted some recent evidence-based data on these promising candidates that could be used as an outline for future research on their medicinal use. PMID: 32316897 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 19, 2020 Category: Drugs & Pharmacology Authors: Hosseinkhani A, Ziaeian B, Hessami K, Zarshenas MM, Kashkooe A, Pasalar M Tags: Curr Drug Discov Technol Source Type: research

Novel and predictive QSAR model for steroidal and nonsteroidal 5 α-Reductase type II Inhibitors.
In this study, novel quantitative structure activity relationship (QSAR) model has been developed for inhibitors of human 5-alpha reductase type II, which are used to treat benign prostate hypertrophy (BPH). The dataset consisted of 113 compounds-mainly nonsteroidal-with known inhibitory concentration. Then 3D structures of compounds were optimized and molecular structure descriptors were calculated. The stepwise multiple linear regression was used to select descriptors encoding the inhibitory activity of the compounds. Multiple linear regression (MLR) was used to build up the linear QSAR model. The results obtained reveal...
Source: Current Drug Discovery Technologies - March 23, 2020 Category: Drugs & Pharmacology Authors: Mando H, Hassan A, Gharaghani S Tags: Curr Drug Discov Technol Source Type: research

A review on pharmacological properties and toxicological effects of Adiantum capillus-veneris L.
CONCLUSION: This plant can be used as a natural potent and safe agent to alleviate numerous medical symptoms and diseases due to its useful pharmacological properties. Thus, further researches are needed in order to compile the clinical effects of this plant via human studies. PMID: 32178614 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 15, 2020 Category: Drugs & Pharmacology Authors: Kashkooe A, Sardari FA, Mehrabadi MM, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

Traditional aspects to sciatic pain and allied therapies from Persian medical reports.
Abstract Sciatica is a common back pain caused by irritation of the sciatic nerve. Current pharmacologic therapies have proven inadequate for many patients with sciatic pain. On the other hand, there is a global increasing demand toward the use and administration of natural medicaments for this disorder. Traditional Persian Medicine (TPM) is a school of medicine and a medicinal plant based resource for clinical studies put forward by Persian scholars. The aim of the present study is to gather and study the effectiveness of all medicinal plants from five main Persian pharmacopeias. Furthermore, different data bases...
Source: Current Drug Discovery Technologies - March 15, 2020 Category: Drugs & Pharmacology Authors: Ansari R, Dadbakhsh A, Hasani F, Hosseinzadeh F, Abolhassanzadeh Z, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

An Analysis of QSAR Research Based on Machine Learning Concepts.
This study systematically reviews the application of machine learning algorithms in QSAR, aiming to provide an analytical framework. For this purpose, we present a framework called 'ML-QSAR'. This framework has been designed for future research to: a)facilitate the selection of proper strategies among existing algorithms according to the application area requirements, b) help to develop and ameliorate current methods and c) providing a platform to study existing methodologies comparatively. In ML-QSAR, first a structured categorization is depicted which studied the QSAR modeling research based on machine models. Then sever...
Source: Current Drug Discovery Technologies - March 14, 2020 Category: Drugs & Pharmacology Authors: Keyvanpour MR, Shirzad MB Tags: Curr Drug Discov Technol Source Type: research

An evidence-based review of medicinal plants used in traditional Persian medicine for treatment of osteoarthritis.
Abstract Osteoarthritis (OA) is known to be the leading cause of pain and disability in the elderly. The prevalence of this disease in adults over 60 years was 9.6% in men and 18% in women. The therapeutic goals of this disease generally include pain relief with the least side effects, improvement of articular function and improvement of life, in which pharmacological and non-pharmacological treatments are performed in different protocols. Due to the common side effects of pain relievers and complaints after invasive joint surgeries, there is a growing interest in the use of Traditional and Complementary protocols...
Source: Current Drug Discovery Technologies - March 14, 2020 Category: Drugs & Pharmacology Authors: Karami S, Shamshiri S, Abdollahi M, Rahimi R Tags: Curr Drug Discov Technol Source Type: research

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein.
Abstract Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academi...
Source: Current Drug Discovery Technologies - March 10, 2020 Category: Drugs & Pharmacology Authors: Sharker SM, Rahman MA Tags: Curr Drug Discov Technol Source Type: research

Analysis of Inhibitor binding combined with reactivity studies to discover the potentially inhibiting phytochemicals targeting Chikungunya viral replication.
CONCLUSION: A total of 13 phytochemicals were identified as potent inhibiting candidates which can be used against Chikungunya virus. PMID: 32164512 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 10, 2020 Category: Drugs & Pharmacology Authors: Rasool N, Bakht A, Hussain W Tags: Curr Drug Discov Technol Source Type: research

Structural and Computational Perspectives of Selectively Targeting Mutant Proteins.
Abstract Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the functional wild type protein. Otherwise, the drugs may even target different proteins with similar structural features. Designing drugs that successfully target mutant proteins selectively represents a major challenge. Decades of cancer research have led to an abundance of potential therapeutic targets, often touted to be "master regulators". For many of these proteins, there are no FDA-approve...
Source: Current Drug Discovery Technologies - March 10, 2020 Category: Drugs & Pharmacology Authors: Coban M, Fraga S, Caulfield T Tags: Curr Drug Discov Technol Source Type: research

Efficacy of honey based ophthalmic formulation in patients with corneal ulcer; A randomized clinical trial.
CONCLUSION: Honey based ophthalmic drop can acceleratethe corneal epithelial defect healing in patients with foreign body induced corneal ulcer, compared to ophthalmic ciprofloxacin as the standard treatment. PMID: 32056528 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 12, 2020 Category: Drugs & Pharmacology Authors: Nejabat M, Soltanzadeh K, Yasemi M, Daneshamouz S, Akbarizadeh AR, Heydari M Tags: Curr Drug Discov Technol Source Type: research

Neuroprotective methodologies in treatment of Multiple Sclerosis: Current status of Clinical and Pre-clinical findings.
Abstract Multiple sclerosis an idiopathic and autoimmune associated motor neuron disorder that attacks myelinated neurons in specific brain regions of young people, especially females; characterized by oligodendrocytes destruction causes demyelination, neuroinflammation, mitochondrial abnormalities, oxidative stress and neurotransmitter deficits associated with motor and cognitive dysfunctions, vertigo and muscle weakness. The limited intervention of pharmacologically active compounds like interferon-β, mitoxantrone, fingolimod and monoclonal antibodies used clinically are majorly associated with adverse drug...
Source: Current Drug Discovery Technologies - February 5, 2020 Category: Drugs & Pharmacology Authors: Kapoor T, Mehan S Tags: Curr Drug Discov Technol Source Type: research

Evaluation of diuretic and antioxidant properties in aqueous bark and fruit extracts of pine.
This study also showed each extract increase creatinine clearance in a dose-dependent manner (p
Source: Current Drug Discovery Technologies - February 4, 2020 Category: Drugs & Pharmacology Authors: Shariati H, Hassanpour M, Sharifzadeh G, Zarban A, Samarghandian S, Saeedi F Tags: Curr Drug Discov Technol Source Type: research

Pharmacological applications of phlorotannins: A comprehensive review.
CONCLUSION: Phlorotannins are characterized as a multifunctional group of natural products. Potential antioxidant characteristics could be attributed to preventive and/or their curative role in various diseases. PMID: 32026778 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 4, 2020 Category: Drugs & Pharmacology Authors: Javed A, Hussain MB, Tahir A, Waheed M, Anwar A, Shariati MA, Plygun S, Laishevtcev A, Pasalar M Tags: Curr Drug Discov Technol Source Type: research