Persian herbal medicine in functional dyspepsia: a systematic review article.
CONCLUSION: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD. PMID: 32525777 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 11, 2020 Category: Drugs & Pharmacology Authors: Azimi M, Zahedi MJ Tags: Curr Drug Discov Technol Source Type: research

Anti-Candida activity of Curcumin: A review.
Abstract Curcumin is one of the important natural compounds that is extracted from turmeric. This compound and its derivatives have numerous biological properties, including antioxidant, anticancer, anti-inflammatory, antimicrobial and healing effects. Extensive research in various fields has been conducted on turmeric as it is widely used as a food additive. The significant antifungal activity is one of the major effects of curcumin. In this paper, recent studies on the effects of different forms of curcumin drug on the candidiasis were systematically examined and discussed. The data in this study were extracted ...
Source: Current Drug Discovery Technologies - May 17, 2020 Category: Drugs & Pharmacology Authors: Cheraghipour K, Ezatpour B, Masoori L, Marzban A, Sepahvand A, Rouzbahani AK, Moridnia A, Khanizadeh S, Mahmoudvand H Tags: Curr Drug Discov Technol Source Type: research

Immunomodulatory effects of medicinal plants used for vitiligo in traditional Persian medicine..
CONCLUSION: According to scientific evidence on immunomodulatory effects, new research into the effects of these plants on vitiligo can lead to the discovery of new drugs and approaches for treating this disease. PMID: 32416680 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - May 17, 2020 Category: Drugs & Pharmacology Authors: Ebrahimabadi MH, Lamardi SNS, Shirbeigi L Tags: Curr Drug Discov Technol Source Type: research

Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent; a Comprehensive Review on Related Investigations.
CONCLUSION: Taken together, botanical parts of P. granatum have possessed notable radical scavenging and antimicrobial activities that with these properties, this plant can be introduced as a natural safe source of preservative and antioxidant. Accordingly, P. granatum can be applied as excipient with the aforementioned properties in the pharmaceutical and food industries. PMID: 32351184 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 29, 2020 Category: Drugs & Pharmacology Authors: Jalali A, Kiafar M, Seddigh M, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

In sillico analysis, synthesis, and biological evaluation of triazole derivatives as a H1 receptor antagonist.
CONCLUSION: Finally, these derivatives were screened for H1 receptor antagonist activity using guinea pig ileum taking chlorpheniramine maleate as a standard. Most of the compounds possesses better antihistamine activity. PMID: 32316895 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 20, 2020 Category: Drugs & Pharmacology Authors: Badeliya SN, Panchal II, Panigrahi B, Patel CN Tags: Curr Drug Discov Technol Source Type: research

Identifying the molecular targets of an anti-pathogenic hydroalcoholic extract of Punica granatum peel against multidrug resistant Serratia marcescens.
CONCLUSION: PGPE's anti-virulence effect against S. marcescens is multifaceted, affecting stress-response machinery, efflux activity, iron homeostasis, and cellular energetics of this bacterium notably. Among the major molecular targets identified in this study are LPS export transporter permease (LptF), t-RNA pseudouridine synthase (TruB), etc. PMID: 32316896 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 20, 2020 Category: Drugs & Pharmacology Authors: Joshi C, Patel P, Godatwar P, Sharma S, Kothari V Tags: Curr Drug Discov Technol Source Type: research

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine.
CONCLUSION: In addition to advantageous effects of antitussive herbs noted by TPM, the present review highlighted some recent evidence-based data on these promising candidates that could be used as an outline for future research on their medicinal use. PMID: 32316897 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 20, 2020 Category: Drugs & Pharmacology Authors: Hosseinkhani A, Ziaeian B, Hessami K, Zarshenas MM, Kashkooe A, Pasalar M Tags: Curr Drug Discov Technol Source Type: research

Novel and predictive QSAR model for steroidal and nonsteroidal 5 α-Reductase type II Inhibitors.
In this study, novel quantitative structure activity relationship (QSAR) model has been developed for inhibitors of human 5-alpha reductase type II, which are used to treat benign prostate hypertrophy (BPH). The dataset consisted of 113 compounds-mainly nonsteroidal-with known inhibitory concentration. Then 3D structures of compounds were optimized and molecular structure descriptors were calculated. The stepwise multiple linear regression was used to select descriptors encoding the inhibitory activity of the compounds. Multiple linear regression (MLR) was used to build up the linear QSAR model. The results obtained reveal...
Source: Current Drug Discovery Technologies - March 24, 2020 Category: Drugs & Pharmacology Authors: Mando H, Hassan A, Gharaghani S Tags: Curr Drug Discov Technol Source Type: research

A review on pharmacological properties and toxicological effects of Adiantum capillus-veneris L.
CONCLUSION: This plant can be used as a natural potent and safe agent to alleviate numerous medical symptoms and diseases due to its useful pharmacological properties. Thus, further researches are needed in order to compile the clinical effects of this plant via human studies. PMID: 32178614 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 16, 2020 Category: Drugs & Pharmacology Authors: Kashkooe A, Sardari FA, Mehrabadi MM, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

Traditional aspects to sciatic pain and allied therapies from Persian medical reports.
Abstract Sciatica is a common back pain caused by irritation of the sciatic nerve. Current pharmacologic therapies have proven inadequate for many patients with sciatic pain. On the other hand, there is a global increasing demand toward the use and administration of natural medicaments for this disorder. Traditional Persian Medicine (TPM) is a school of medicine and a medicinal plant based resource for clinical studies put forward by Persian scholars. The aim of the present study is to gather and study the effectiveness of all medicinal plants from five main Persian pharmacopeias. Furthermore, different data bases...
Source: Current Drug Discovery Technologies - March 16, 2020 Category: Drugs & Pharmacology Authors: Ansari R, Dadbakhsh A, Hasani F, Hosseinzadeh F, Abolhassanzadeh Z, Zarshenas MM Tags: Curr Drug Discov Technol Source Type: research

An Analysis of QSAR Research Based on Machine Learning Concepts.
This study systematically reviews the application of machine learning algorithms in QSAR, aiming to provide an analytical framework. For this purpose, we present a framework called 'ML-QSAR'. This framework has been designed for future research to: a)facilitate the selection of proper strategies among existing algorithms according to the application area requirements, b) help to develop and ameliorate current methods and c) providing a platform to study existing methodologies comparatively. In ML-QSAR, first a structured categorization is depicted which studied the QSAR modeling research based on machine models. Then sever...
Source: Current Drug Discovery Technologies - March 15, 2020 Category: Drugs & Pharmacology Authors: Keyvanpour MR, Shirzad MB Tags: Curr Drug Discov Technol Source Type: research

An evidence-based review of medicinal plants used in traditional Persian medicine for treatment of osteoarthritis.
Abstract Osteoarthritis (OA) is known to be the leading cause of pain and disability in the elderly. The prevalence of this disease in adults over 60 years was 9.6% in men and 18% in women. The therapeutic goals of this disease generally include pain relief with the least side effects, improvement of articular function and improvement of life, in which pharmacological and non-pharmacological treatments are performed in different protocols. Due to the common side effects of pain relievers and complaints after invasive joint surgeries, there is a growing interest in the use of Traditional and Complementary protocols...
Source: Current Drug Discovery Technologies - March 15, 2020 Category: Drugs & Pharmacology Authors: Karami S, Shamshiri S, Abdollahi M, Rahimi R Tags: Curr Drug Discov Technol Source Type: research

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein.
Abstract Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academi...
Source: Current Drug Discovery Technologies - March 11, 2020 Category: Drugs & Pharmacology Authors: Sharker SM, Rahman MA Tags: Curr Drug Discov Technol Source Type: research

Analysis of Inhibitor binding combined with reactivity studies to discover the potentially inhibiting phytochemicals targeting Chikungunya viral replication.
CONCLUSION: A total of 13 phytochemicals were identified as potent inhibiting candidates which can be used against Chikungunya virus. PMID: 32164512 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 11, 2020 Category: Drugs & Pharmacology Authors: Rasool N, Bakht A, Hussain W Tags: Curr Drug Discov Technol Source Type: research

Structural and Computational Perspectives of Selectively Targeting Mutant Proteins.
Abstract Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the functional wild type protein. Otherwise, the drugs may even target different proteins with similar structural features. Designing drugs that successfully target mutant proteins selectively represents a major challenge. Decades of cancer research have led to an abundance of potential therapeutic targets, often touted to be "master regulators". For many of these proteins, there are no FDA-approve...
Source: Current Drug Discovery Technologies - March 11, 2020 Category: Drugs & Pharmacology Authors: Coban M, Fraga S, Caulfield T Tags: Curr Drug Discov Technol Source Type: research

Efficacy of honey based ophthalmic formulation in patients with corneal ulcer; A randomized clinical trial.
CONCLUSION: Honey based ophthalmic drop can acceleratethe corneal epithelial defect healing in patients with foreign body induced corneal ulcer, compared to ophthalmic ciprofloxacin as the standard treatment. PMID: 32056528 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 13, 2020 Category: Drugs & Pharmacology Authors: Nejabat M, Soltanzadeh K, Yasemi M, Daneshamouz S, Akbarizadeh AR, Heydari M Tags: Curr Drug Discov Technol Source Type: research

Neuroprotective methodologies in treatment of Multiple Sclerosis: Current status of Clinical and Pre-clinical findings.
Abstract Multiple sclerosis an idiopathic and autoimmune associated motor neuron disorder that attacks myelinated neurons in specific brain regions of young people, especially females; characterized by oligodendrocytes destruction causes demyelination, neuroinflammation, mitochondrial abnormalities, oxidative stress and neurotransmitter deficits associated with motor and cognitive dysfunctions, vertigo and muscle weakness. The limited intervention of pharmacologically active compounds like interferon-β, mitoxantrone, fingolimod and monoclonal antibodies used clinically are majorly associated with adverse drug...
Source: Current Drug Discovery Technologies - February 6, 2020 Category: Drugs & Pharmacology Authors: Kapoor T, Mehan S Tags: Curr Drug Discov Technol Source Type: research

Evaluation of diuretic and antioxidant properties in aqueous bark and fruit extracts of pine.
This study also showed each extract increase creatinine clearance in a dose-dependent manner (p
Source: Current Drug Discovery Technologies - February 5, 2020 Category: Drugs & Pharmacology Authors: Shariati H, Hassanpour M, Sharifzadeh G, Zarban A, Samarghandian S, Saeedi F Tags: Curr Drug Discov Technol Source Type: research

Pharmacological applications of phlorotannins: A comprehensive review.
CONCLUSION: Phlorotannins are characterized as a multifunctional group of natural products. Potential antioxidant characteristics could be attributed to preventive and/or their curative role in various diseases. PMID: 32026778 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 5, 2020 Category: Drugs & Pharmacology Authors: Javed A, Hussain MB, Tahir A, Waheed M, Anwar A, Shariati MA, Plygun S, Laishevtcev A, Pasalar M Tags: Curr Drug Discov Technol Source Type: research

An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine.
CONCLUSION: Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments. PMID: 32013832 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 2, 2020 Category: Drugs & Pharmacology Authors: Hasheminasab FS, Sharififar F, Hashemi SM, Setayesh M Tags: Curr Drug Discov Technol Source Type: research

Evaluation of Ficus retusa L. Leaves with special reference to Anti-diarrheal and Anti-spasmodic activity.
The objective of the present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models. In very first step, phytochemical test was done to evaluate the presence of secondary metabolites. Quantitative test revealed that flavanoid is present in 24.48±0.40 mg/100g of extract, which is in highest among all the secondary metabolites present. The anti-diarrheal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine (5HT) induced diarrhea. Further, the extract was subjected to gastrointestinal moti...
Source: Current Drug Discovery Technologies - January 27, 2020 Category: Drugs & Pharmacology Authors: Khan NA, Tomar C, Shrivastav A, Ahmad A, Mishra AK Tags: Curr Drug Discov Technol Source Type: research

Formulation, Standardization and a Preliminary Before-After Clinical Trial on Effect of a Traditional Herbal Formula (Maqliasa) on Manifestations of Ulcerative Colitis.
CONCLUSIONS: This study showed the promising effect of Maqliasa in the treatment of active UC. However, due to some of the limitations of the study, conducting future high-quality randomized clinical trials would be crucial. PMID: 31985380 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - January 27, 2020 Category: Drugs & Pharmacology Authors: Shirzad M, Ahmadian-Attari MM, Ghafoori SMS, Kashani LMT, Pasalar M, Abbassian A, Agah S Tags: Curr Drug Discov Technol Source Type: research

Fractions of Boswellia serrata suppress LTA4, LTC4, Cyclooxygenase-2 activities and mRNA in HL-60 Cells and reduce lung inflammation in BALB/c mice.
Abstract BACKGROUND: Purified fractions from a Boswellia serrata Roxb. Ex. Colebr. (Burseraceae) extract (ETOH and DCM) contain biologically active compounds that are well known for having inflammation inhibitory properties. In this work, the purified fractions were tested in-vitro for LTC4, LTA4 and COX-2 activities using ELISA and qPCR was performed to determine gene regulation in human leukemia (HL-60) Cells. Two D-imaging tomography was performed to determine the anti-inflammatory activities of the fractions in BALB/c mouse model of lung inflammation. OBJECTIVE: To evaluate anti-inflammatory activities of...
Source: Current Drug Discovery Technologies - January 26, 2020 Category: Drugs & Pharmacology Authors: Soni KK, Meshram D, Lawal TO, Patel U, Mahady GB Tags: Curr Drug Discov Technol Source Type: research

The potential role of tea in periodontal therapy: An updated review.
Abstract Periodontal diseases are highly prevalent and can affect high percentage of the world population. Oxidative stress and inflammation plays an important role in the pathogenesis of periodontal diseases. Nowadays, more attention has been focused on the herbal remedies in the field of drug discovery. Green tea is an important source of polyphenol antioxidants, it has long been used as a beverage worldwide. The most interesting polyphenol components of green tea leaves that are related with health benefits are the catechins. Taken together this review suggested that green tea with its wide spectrum of activiti...
Source: Current Drug Discovery Technologies - January 26, 2020 Category: Drugs & Pharmacology Authors: Forouzanfar A, Mohammadipour HS, Forouzanfar F Tags: Curr Drug Discov Technol Source Type: research

Current Development on Chitosan-based Antimicrobial Drug Formulations for the Wound Healing.
Conclusion: The present article discusses the development of various drug formulations utilizing chitosan as biopolymers for the repairing of broken tissues in case of wound infection. PMID: 31971111 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - January 23, 2020 Category: Drugs & Pharmacology Authors: Roy H, Rahaman SA, Kumar TV, Nandi S Tags: Curr Drug Discov Technol Source Type: research

In silico-based approach to investigate the ability of PEGylated rapamycin to inhibit Galectin-3.
In this study, we have investigated the ability of modified rapamycin (RP) to bind to the carbohydrate recognition domain of Gal-3. Briefly, various molecular weights of methoxy polyethylene glycols (MPEG) were conjugated with RP to obtain RP-MPEG compounds with molecular weights of 1002.29, 1090.40, 1178.51, 1266.6 and 1354.72 g/mol. Furthermore, the molecules were docked with Gal-3 using MOE.2014 software. According to the results obtained from the molecular modeling algorithm based on shape complementarity principles, RP-MPEG with the molecular weight of 1178.51 g/mol and a logP value of 3.79 has the best affinity for a...
Source: Current Drug Discovery Technologies - January 22, 2020 Category: Drugs & Pharmacology Authors: Abdelkarim Maki MA, Kumar PV, Elumalai M, Bayazeid O Tags: Curr Drug Discov Technol Source Type: research

Review of Phytochemical Compounds as Antiviral Agents against Arboviruses from the Genera Flavivirus and Alphavirus.
Abstract Arboviruses are a diverse group of viruses that are among the major causes of emerging infectious diseases. Arboviruses from the genera flavivirus and alphavirus are the most important human arboviruses from a public health perspective. During recent decades, these viruses have been responsible for millions of infections and deaths around the world. Over the past few years, several investigations have been carried out to identify antiviral agents to treat these arbovirus infections. The use of synthetic antiviral compounds is often unsatisfactory since they may raise the risk of viral mutation, they are c...
Source: Current Drug Discovery Technologies - January 21, 2020 Category: Drugs & Pharmacology Authors: Sardari S, Rafieian-Kopaei M, Malekmohammad K, Sewell RDE Tags: Curr Drug Discov Technol Source Type: research

Alcoholic and Non-Alcoholic Liver Diseases: Promising Molecular Drug Targets and their Clinical Development.
Abstract Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world. Both these liver diseases have an identical pathology, starting from simple steatosis to cirrhosis and ultimately to hepatocellular carcinoma. Treatment options for alcoholic liver disease (ALD) are still same as it was 50 years ago which includes corticosteroids, pentoxifylline, antioxidants, nutritional support and abstinence; and for non-alcoholic fatty liver disease (NAFLD) weight loss, insulin sensitizers, lipid lowering agents and anti-oxidants are the only treatment options. Despite of broad researc...
Source: Current Drug Discovery Technologies - January 21, 2020 Category: Drugs & Pharmacology Authors: Thapa K, Grewal AS, Kanojia N, Rani L, Sharma N, Singh S Tags: Curr Drug Discov Technol Source Type: research

The Influence of Hydrogen atoms on the Performance of Radial Distribution Function Based Descriptors in the Chemoinformatic Studies of HIV-1 Prote-ase Complexes with Inhibitors.
Abstract In this letter the newly introduced approach based on the radial distribution function (RDF) weighted by the number of va-lence shell electrons is applied for a series of HIV-1 protease enzyme and its complexes with inhibitors to evaluate the influ-ence of hydrogen atoms on the performance of the model. The multiple linear regression method was used for the selection of the relevant descriptors. Two groups of residues having dominant contribution to the RDF descriptor are identified as relevant for the inhibition. In the first group are residues like Arg8, Asp25, Thr26, Gly27 and Asp29, which establish di...
Source: Current Drug Discovery Technologies - January 2, 2020 Category: Drugs & Pharmacology Authors: Novak J, Grishina MA, Potemkin VA Tags: Curr Drug Discov Technol Source Type: research

β-D-Mannuronic Acid (M2000) as a landmark in Pharmacology.
CONCLUSION: β-D-Mannuronic Acid (M2000) as a novel immunosuppressive drug with NSAID properties along with antidiabetic, cardioprotective and anti-tumoral efficacy showed great tolerability and safety profile. In addition, it has no or mild adverse events compared with many other medicines, therefore this medicament could be considered as a landmark in pharmacology and represent turn point in the treatment of different diseases based on the experimental and in vitro studies explained and clinical and related studies proved. PMID: 31880246 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 27, 2019 Category: Drugs & Pharmacology Authors: Gaafar NAG, Razavi A, Mirshafiey A Tags: Curr Drug Discov Technol Source Type: research

Herbal Drugs: Expanding Horizons of Contemporary Therapeutics.
PMID: 31845626 [PubMed - in process] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 19, 2019 Category: Drugs & Pharmacology Authors: Mahant S Tags: Curr Drug Discov Technol Source Type: research

Network Pharmacology Approach uncovering Pathways involved in targeting Hsp90 through Curcumin and Epigallocatechin to control Inflammation.
Abstract Hsp90 are molecular chaperones of chronic inflammatory proteins and have emerged as prime target for treatment of inflammation. Principal components from Curcuma longa and Camellia sinensis, Curcumin and EGC respectively possesses anti-inflammatory properties inhibiting cytokines responsible for inflammation. Both act on common pathways in upregulation of heme oxygenase 1 through Pkcδ-Nrf2 pathway and downregulation of Tlr4, which in turn suppress expression of Hsp90. Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively. Based on this, work was designed with netwo...
Source: Current Drug Discovery Technologies - December 10, 2019 Category: Drugs & Pharmacology Authors: Umme Hani, Kandagalla S, Sharath BS, Jyothsna K, Manjunatha H Tags: Curr Drug Discov Technol Source Type: research

Insights into the FDA 2018 new drug approvals.
CONCLUSION: The new drugs approved by FDA in 2018 have been reviewed. This year showed the highest number of new drug approvals in the last two decades. Among the 59 drugs approved in 2018, 14 drugs are considered breakthrough which revives hope for many poorly managed diseases. The list also contains 19 drugs that are first in class and 43 that were given priority reviews. PMID: 31793428 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 1, 2019 Category: Drugs & Pharmacology Authors: Bedair A, Mansour FR Tags: Curr Drug Discov Technol Source Type: research

Identification of inhibitors based on molecular docking: Thyroid hormone transporter MCT8 as a target.
CONCLUSION: This study reveals that these compounds could be promising candidates for further evaluation for AHDS prevention. PMID: 31774046 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 25, 2019 Category: Drugs & Pharmacology Authors: Shaji D Tags: Curr Drug Discov Technol Source Type: research

In Silico Drug-Designing Studies on Sulforaphane Analogues: Pharmacophore Mapping, Molecular Docking and QSAR Modeling.
CONCLUSION: Conclusively, the validated QSAR model was applied on the hits to calculate their inducer potencies and these 12 hits were introduced as potential NQO1 inducers for further investing action. PMID: 31721705 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 12, 2019 Category: Drugs & Pharmacology Authors: Vaghefinezhad N, Farsani SF, Gharaghani S Tags: Curr Drug Discov Technol Source Type: research

Prediction of Lipophilicity of some Quinolone Derivatives by using Quantitative Structure- Activity Relationship.
Abstract Quantitative structure activity relationship (QSAR) was used to study the partition coefficient of some quinolones and their derivatives. These molecules are broad-spectrum antibiotic pharmaceutics. First, data were divided into two categories of train and test (validation) sets using random selection method. Second, three approaches including stepwise selection (STS) (forward), genetic algorithm (GA), and simulated annealing (SA) were used to select the descriptors, with the aim of examining the effect feature selection methods. To find the relation between descriptors and partition coefficient, multiple...
Source: Current Drug Discovery Technologies - November 8, 2019 Category: Drugs & Pharmacology Authors: Shirmohammadi M, Bayat Z, Mohammadinasab E Tags: Curr Drug Discov Technol Source Type: research

Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy.
Abstract Quorum sensing (QS) is a phenomenon in which bacterial cells communicate with each other with the help of several low molecular weight compounds. QS is largely dependent on population density, and it triggers when the concentration of quorum sensing molecules accumulate in the environment and crosses a particular threshold Once a certain population density is achieved and the concentration of molecules cross a threshold the bacterial cells show a collective behavior in response to various chemical stimuli referred to as "auto-inducers". The QS signaling is crucial for several phenotypic characte...
Source: Current Drug Discovery Technologies - November 7, 2019 Category: Drugs & Pharmacology Authors: Mujawdiya PK, Kapur S Tags: Curr Drug Discov Technol Source Type: research

Phytoextracts As Antibacterials - A Review.
Abstract Botanicals have been cultured to flavour food, to treat health disorders and to put a stop to diseases caused by various microorganisms. The awareness of curative features of different medicinal plants has been spread among human communities. The application of herbal products as antimicrobial agents may be a better choice to the extensive and imprudent use of synthetic antibiotics. World Health Organization recommended traditional medicines as safest remedies for treatment of diseases of microbial origin. The plant extracts are generally non-hazardous, available in plenty at reasonable prices, biodegrada...
Source: Current Drug Discovery Technologies - November 5, 2019 Category: Drugs & Pharmacology Authors: Chandra G, Mukherjee D, Ray AS, Chatterjee S, Bhattacharjee I Tags: Curr Drug Discov Technol Source Type: research

Moringa Oleifera in Malnutrition: A Comprehensive Review.
Abstract Nutritional deficiency is a major concern in developing countries resulting in serious health consequences like mental and physical growth retardation. Moringa oleifera(Moringa), a nutritious plantgrowing in tropical regions of developing countries, is a candidate for overcoming nutritional deficiency. Moringa leaves are rich in protein including Sulphur containing amino acids.It contains high amounts of vitamin C than oranges, higher concentration of vitamin A than carrots, higher calcium content than milk and more potassium than bananas. Moreover, there is 9 times more iron in moringa than spinach, 4 ti...
Source: Current Drug Discovery Technologies - November 5, 2019 Category: Drugs & Pharmacology Authors: Mushtaq BS, Hussain MB, Omer R, Toor HA, Waheed M, Shariati MA, Sergey P, Heydari M Tags: Curr Drug Discov Technol Source Type: research

Risperidone: A Commentary on Drug Profiling.
;as R Abstract PMID: 31642766 [PubMed - in process] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 25, 2019 Category: Drugs & Pharmacology Authors: Werner FM, Coveñas R Tags: Curr Drug Discov Technol Source Type: research

Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation.
CONCLUSIONS: We, therefore, put forward a logical argument that kaempferol can be further evaluated as a potential PAK4 inhibitor in TNBC. PMID: 31441728 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 23, 2019 Category: Drugs & Pharmacology Authors: Arowosegbe MA, Amusan OT, Adeola SA, Adu OB, Akinola IA, Ogungbe BF, Omotuyi OI, Saibu GM, Ogunleye AJ, Kanmodi RI, Lugbe NE, Ogunmola OJ, Ajayi DC, Ogun SO, Oyende FO, Bello AO, Ishola AO, Obasieke PE Tags: Curr Drug Discov Technol Source Type: research

The Parsnip (Pastinaca sativa L), A proposed remedy as to a fertile agent in the viewpoint of Iranian traditional medicine.
CONCLUSION: In some studies, the effects of the parsnip on spermatogenesis, number, and sperm motility are investigated but no studies have been done on women's infertility. This review shows that the parsnip can be as a fertile agent in female infertility. So, further clinical research is recommended. PMID: 31429690 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 20, 2019 Category: Drugs & Pharmacology Authors: Hakimi F, Tansaz M, Nejad RM Tags: Curr Drug Discov Technol Source Type: research

Exploring antimicrobials from the flora and fauna of marine: Opportunities and limitations.
The objective of this review article is to provide an overview of marine resources, recently reported research from marine resources, challenges, future research prospects in the marine environment. PMID: 31424372 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 19, 2019 Category: Drugs & Pharmacology Authors: Venkateskumar K, Parasuraman S, Chuen LY, Ravichandran V, Balamurgan S Tags: Curr Drug Discov Technol Source Type: research

Targeting Small Molecule Tyrosine Kinases by Polyphenols: New Move Towards Anti-tumor Drug Discovery.
CONCLUSION: In this review, we have discussed about the role of polyphenols as chemoreceptive which will help in future for the development and discovery of novel semisynthetic anticancer agents coupled with polyphenols. PMID: 31393251 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 8, 2019 Category: Drugs & Pharmacology Authors: Sakle NS, More SA, Dhawale SA, Mokale SN Tags: Curr Drug Discov Technol Source Type: research

Therapeutic potentials of Scavenger receptor CD36 mediated innate immune responses against infectious and non-infectious diseases.
Abstract CD36 is a multifunctional glycoprotein, expressed in different types of cells and known to play a significant role in the pathophysiology of the host. The structural studies revealed that the scavenger receptor consists of short cytosolic domains, two transmembrane domains and a large ectodomain. The ectodomain serves as a receptor for a diverse number of endogenous and exogenous ligands. The CD36-specific ligands are involved in regulating the immune response during infectious and non-infectious diseases in the host. The role of CD36 in regulating the innate immune response during Pneumonia, Tuberculosis...
Source: Current Drug Discovery Technologies - August 2, 2019 Category: Drugs & Pharmacology Authors: Banesh S, Trivedi V Tags: Curr Drug Discov Technol Source Type: research

Zebra Fish in Toxicology Research: Streptavidin conjugated peroxidase assay in development phase of zebra fish embryos to study liver toxicities.
Abstract Zebrafish have a similar hepatic anatomy and cellular architecture with mammals. Therefore, number of investigators are using zebrafish to study liver pathologies. However, the evaluation model specific to liver toxicities in zebra fish was not clearly stated earlier. The present study was designed to develop a model of embryonic liver toxicity using dexamethasone (DEXA, 0-20 µM) as standard hepatotoxic agent and such toxicities easily measured by streptavidin conjugated peroxidase assay after 48 hour post fertilization (hpf) of DEXA treatment. In addition to morphological toxicities at different hp...
Source: Current Drug Discovery Technologies - August 1, 2019 Category: Drugs & Pharmacology Authors: Bala A, Mondal C, Haldar PK Tags: Curr Drug Discov Technol Source Type: research

Stopping the Unstoppable: Unconventional methods to prevent biofilm growth.
Abstract Biofilms are consortia of microorganisms encased in extracellular matrix that protect cells from adverse conditions. A biofilm matrix is typically composed of extracellular DNA, cellulose and proteinaceous amyloid fibers. The matrix aids in adhesion to abiotic and biotic surface including medical devices and host tissues. Presence of biofilm makes bacteria more resilient and non-responsive to most current treatment regimes at disposal. Therefore, biofilm-associated infections are serious threat in hospital settings and pose a huge burden on economy. Inhibition of matrix components (cellulose and/or amyloi...
Source: Current Drug Discovery Technologies - July 26, 2019 Category: Drugs & Pharmacology Authors: Jain N, Mansuri A Tags: Curr Drug Discov Technol Source Type: research

Discovery and Development of Novel Anti-fungal Peptides Against Food-spoiling Fungi.
Conclusions: Antifungal peptides generated by certain lactic acid bacteria strains have high potential for applications in broad range of foods. The mechanism of peptides antifungal activity is related to their properties such as low molecular weight, concentration and secondary structure. The antifungal peptides were proposed to be used as bio-preservatives to reduce and/or replace chemical preservatives. PMID: 31309892 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Muhialdin BJ, Algboory HL, Mohammed NK, Kadum H, Hussin ASM, Saari N, Hassan Z Tags: Curr Drug Discov Technol Source Type: research

Novel Nanotherapeutics as Next-generation Anti-infective agents: Current Trends and Future Prospectives.
Abstract With the ever-increasing population and improvement in the healthcare system in the 21st century, the incidence of chronic microbial infections and associated health disorders also increased at a striking pace. The ability of pathogenic microorganisms to form biofilm matrix aggravate the situation due to the occurrence of antibiotic resistance phenomenon resulting in resistance against conventional antibiotic therapy and become a public health concern. The canonical quorum sensing (QS) signaling system hierarchially regulates the expression of an array of virulence phenotypes and controls the development ...
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Subhaswaraj P, Syed A, Siddhardha B Tags: Curr Drug Discov Technol Source Type: research

Effective antiviral medicinal plants and biological compounds against central nervous system infections: A mechanistic review.
CONCLUSION: Due to the increased resistance of microorganisms (bacteria, viruses and parasites) to antimicrobial therapies, alternative treatments, especially using plant sources and their bioactive constituents, appear to be more fruitful. PMID: 31309894 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Malekmohammad K, Rafieian-Kopaei M, Sardari S, Sewell RDE Tags: Curr Drug Discov Technol Source Type: research