The Parsnip (Pastinaca sativa L), A proposed remedy as to a fertile agent in the viewpoint of Iranian traditional medicine.
CONCLUSION: In some studies, the effects of the parsnip on spermatogenesis, number, and sperm motility are investigated but no studies have been done on women's infertility. This review shows that the parsnip can be as a fertile agent in female infertility. So, further clinical research is recommended. PMID: 31429690 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 20, 2019 Category: Drugs & Pharmacology Authors: Hakimi F, Tansaz M, Nejad RM Tags: Curr Drug Discov Technol Source Type: research

Exploring antimicrobials from the flora and fauna of marine: Opportunities and limitations.
The objective of this review article is to provide an overview of marine resources, recently reported research from marine resources, challenges, future research prospects in the marine environment. PMID: 31424372 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 19, 2019 Category: Drugs & Pharmacology Authors: Venkateskumar K, Parasuraman S, Chuen LY, Ravichandran V, Balamurgan S Tags: Curr Drug Discov Technol Source Type: research

Targeting Small Molecule Tyrosine Kinases by Polyphenols: New Move Towards Anti-tumor Drug Discovery.
CONCLUSION: In this review, we have discussed about the role of polyphenols as chemoreceptive which will help in future for the development and discovery of novel semisynthetic anticancer agents coupled with polyphenols. PMID: 31393251 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 8, 2019 Category: Drugs & Pharmacology Authors: Sakle NS, More SA, Dhawale SA, Mokale SN Tags: Curr Drug Discov Technol Source Type: research

Therapeutic potentials of Scavenger receptor CD36 mediated innate immune responses against infectious and non-infectious diseases.
Abstract CD36 is a multifunctional glycoprotein, expressed in different types of cells and known to play a significant role in the pathophysiology of the host. The structural studies revealed that the scavenger receptor consists of short cytosolic domains, two transmembrane domains and a large ectodomain. The ectodomain serves as a receptor for a diverse number of endogenous and exogenous ligands. The CD36-specific ligands are involved in regulating the immune response during infectious and non-infectious diseases in the host. The role of CD36 in regulating the innate immune response during Pneumonia, Tuberculosis...
Source: Current Drug Discovery Technologies - August 2, 2019 Category: Drugs & Pharmacology Authors: Banesh S, Trivedi V Tags: Curr Drug Discov Technol Source Type: research

Zebra Fish in Toxicology Research: Streptavidin conjugated peroxidase assay in development phase of zebra fish embryos to study liver toxicities.
Abstract Zebrafish have a similar hepatic anatomy and cellular architecture with mammals. Therefore, number of investigators are using zebrafish to study liver pathologies. However, the evaluation model specific to liver toxicities in zebra fish was not clearly stated earlier. The present study was designed to develop a model of embryonic liver toxicity using dexamethasone (DEXA, 0-20 µM) as standard hepatotoxic agent and such toxicities easily measured by streptavidin conjugated peroxidase assay after 48 hour post fertilization (hpf) of DEXA treatment. In addition to morphological toxicities at different hp...
Source: Current Drug Discovery Technologies - August 1, 2019 Category: Drugs & Pharmacology Authors: Bala A, Mondal C, Haldar PK Tags: Curr Drug Discov Technol Source Type: research

Stopping the Unstoppable: Unconventional methods to prevent biofilm growth.
Abstract Biofilms are consortia of microorganisms encased in extracellular matrix that protect cells from adverse conditions. A biofilm matrix is typically composed of extracellular DNA, cellulose and proteinaceous amyloid fibers. The matrix aids in adhesion to abiotic and biotic surface including medical devices and host tissues. Presence of biofilm makes bacteria more resilient and non-responsive to most current treatment regimes at disposal. Therefore, biofilm-associated infections are serious threat in hospital settings and pose a huge burden on economy. Inhibition of matrix components (cellulose and/or amyloi...
Source: Current Drug Discovery Technologies - July 26, 2019 Category: Drugs & Pharmacology Authors: Jain N, Mansuri A Tags: Curr Drug Discov Technol Source Type: research

Discovery and Development of Novel Anti-fungal Peptides Against Food-spoiling Fungi.
Conclusions: Antifungal peptides generated by certain lactic acid bacteria strains have high potential for applications in broad range of foods. The mechanism of peptides antifungal activity is related to their properties such as low molecular weight, concentration and secondary structure. The antifungal peptides were proposed to be used as bio-preservatives to reduce and/or replace chemical preservatives. PMID: 31309892 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Muhialdin BJ, Algboory HL, Mohammed NK, Kadum H, Hussin ASM, Saari N, Hassan Z Tags: Curr Drug Discov Technol Source Type: research

Novel Nanotherapeutics as Next-generation Anti-infective agents: Current Trends and Future Prospectives.
Abstract With the ever-increasing population and improvement in the healthcare system in the 21st century, the incidence of chronic microbial infections and associated health disorders also increased at a striking pace. The ability of pathogenic microorganisms to form biofilm matrix aggravate the situation due to the occurrence of antibiotic resistance phenomenon resulting in resistance against conventional antibiotic therapy and become a public health concern. The canonical quorum sensing (QS) signaling system hierarchially regulates the expression of an array of virulence phenotypes and controls the development ...
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Subhaswaraj P, Syed A, Siddhardha B Tags: Curr Drug Discov Technol Source Type: research

Effective antiviral medicinal plants and biological compounds against central nervous system infections: A mechanistic review.
CONCLUSION: Due to the increased resistance of microorganisms (bacteria, viruses and parasites) to antimicrobial therapies, alternative treatments, especially using plant sources and their bioactive constituents, appear to be more fruitful. PMID: 31309894 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 15, 2019 Category: Drugs & Pharmacology Authors: Malekmohammad K, Rafieian-Kopaei M, Sardari S, Sewell RDE Tags: Curr Drug Discov Technol Source Type: research

In Silico Screening Reveals Histone Deacetylase 7 and ERK1/2 as Potential Targets for Artemisinin Dimer and Artemisinin Dimer Hemisuccinate.
CONCLUSION: This findings suggest that artemisinin dimer and artemisinin dimer hemisuccinate could be promising anticancer drug agents, with better therapeutic efficacy than ulixertinib and apicidin in the treatment of cancer via inhibition of HDAC7, ERK1 and ERK2. PMID: 31284865 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - July 5, 2019 Category: Drugs & Pharmacology Authors: Ishola AA, Adewole KE Tags: Curr Drug Discov Technol Source Type: research

Statins as the Controlling Agents for Non-Hodgkin's Lymphomas via Increasing the Casein Kinase 2 Interacting Protein-1: A Hypothesis.
CONCLUSION: Present review confirms the positive effect of statins on NHL by increasing CKIP-1 and reducing cell proliferation, subsequently. PMID: 31264550 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 28, 2019 Category: Drugs & Pharmacology Authors: Kazemi K, Mozafari N, Ashrafi H, Rafiei P, Azadi A Tags: Curr Drug Discov Technol Source Type: research

A definitive pharmacophore modelling study on CDK2 ATP pocket binders: tracing the path of new virtual high-throughput screenings.
Abstract Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidences indicate that excessive expression of CDK2s should cause abnormal cell cycle regulation. Therefore, since long time, CDK2s have been considered potential therapeutic targets for cancer therapy. In this work, one-hundred and forty-nine complexes of inhibitors bound in the CDK2-ATP pocket were submitted to short MD simulations (10ns) and free energy calculati...
Source: Current Drug Discovery Technologies - June 20, 2019 Category: Drugs & Pharmacology Authors: Tutone M, Culletta G, Livecchi L, Almerico AM Tags: Curr Drug Discov Technol Source Type: research

The oral administration effect of drug mannuronic acid (M2000) on gene expression of matrix and tissue inhibitor of metalloproteinases in rheumatoid arthritis patients.
Conclusion; our findings proved that the β -D- mannuronic acid) as a novel NSAID with immunosuppressive property has a significant effect on the gene expression level of MMP2, MMP9 and TIMP2 molecules in RA patients. PMID: 31250758 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 20, 2019 Category: Drugs & Pharmacology Authors: Gaafar NAG, Aslani M, Aghazadeh Z, Razavi A, Mirshafiey A Tags: Curr Drug Discov Technol Source Type: research

Nanoparticles and Its Implications in HIV/AIDS Therapy.
Abstract The use of antiretroviral drugs to treat HIV/AIDS patients has enormously increased their life spans with serious disadvantages. The virus infection still remains a public health problem worldwide with no cure and vaccine for the viral agent until now. The use of nanoparticles (NPs) for the prevention and treatment of HIV/AIDS is an emerging technology of the 21st century. NPs are solid, colloidal particles with size range from 10 nm to
Source: Current Drug Discovery Technologies - June 20, 2019 Category: Drugs & Pharmacology Authors: Victor OB Tags: Curr Drug Discov Technol Source Type: research

Antimicrobial Peptides: An Approach to Combat Resilient Infections.
CONCLUSION: Antimicrobial peptides (AMPs) are short, cationic peptides evolved in a wide range of living organisms and serve as the essential part of host innate immunity. For humans, these effector molecules either can directly kill the foreign microbes or modulate the host immune systems so that human body could make some resistance against the microbial infections. In this review, we discuss their history, structural classifications, modes of action, and explain their biological roles as anti-infective agents. We also scrutinize their clinical potentiality, current limitations in various developmental stages and strateg...
Source: Current Drug Discovery Technologies - June 20, 2019 Category: Drugs & Pharmacology Authors: Parai D, Dey P, Mukherjee SK Tags: Curr Drug Discov Technol Source Type: research

The effect of viola odorata l. Oil for fever in children: a randomized triple-blinded placebo-controlled clinical trial.
CONCLUSION: The results of our study showed the safety and efficacy of complementary therapy with Viola odorata L. oil for fever control in febrile neutropenic children during hospital course. PMID: 31250761 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 20, 2019 Category: Drugs & Pharmacology Authors: Tafazoli V, Shahriari M, Heydari M, Nikbakht HA, Zarshenaas MM, Nimrouzi M Tags: Curr Drug Discov Technol Source Type: research

Large-scale high-throughput screening revealed 5'-(carbonylamino)-2,3'-bithiophene-4'-carboxylate as novel template for antibacterial agents.
ximova MA, Zileeva ZR, Vakhitova YV, Bezrukov DS, Puchinina MM, Dontsova OA Abstract Herein, we present the results of high-throughput screening (HTS) campaign, that has been performed utilizing our HTS platform based on unique double-reporter system - pDualrep2. A large-scale small molecule library was designed and tested. As a result, 5'-(carbonylamino)-2,3'-bithiophene-4'-carboxylate derivates were observed as novel class of antibacterials with promising potency. One of the he most active compounds showed a minimal inhibitory concentration (MIC) value of 1.8 µg/mL and induced weak SOS respo...
Source: Current Drug Discovery Technologies - June 2, 2019 Category: Drugs & Pharmacology Authors: Ivanenkov YA, Yamidanov RS, Osterman IA, Sergiev PV, Aladinskiy VA, Aladinskaya AV, Terentiev VA, Veselov MS, Ayginin AA, Skvortsov DA, Komarova KS, Zagribelnyy BA, Baimiev AK, Shvetc KY, Baimiev AK, Sofronova AA, Machulkin AE, Petrov RA, Zainullina LF, M Tags: Curr Drug Discov Technol Source Type: research

Exploring the potential of capsaicin against cancer metastasis based on TGF- β signaling modulation through module based network pharmacology approach.
Exploring the potential of capsaicin against cancer metastasis based on TGF-β signaling modulation through module based network pharmacology approach. Curr Drug Discov Technol. 2019 May 14;: Authors: Kandagalla S, B S S, Pavan G, Hani U, H M Abstract Capsaicin is an active alkaloid /principal component of red pepper responsible for the pungency of chili pepper. Capsaicin by changing the intracellular redox homeostasis regulate a variety of signaling pathways ultimately produces a divergent cellular outcome. Several reports showed the potential of capsaicin against cancer metastasis, however unexp...
Source: Current Drug Discovery Technologies - May 14, 2019 Category: Drugs & Pharmacology Authors: Kandagalla S, B S S, Pavan G, Hani U, H M Tags: Curr Drug Discov Technol Source Type: research

Drug Stereochemistry: A Prodigy For Pharmacology And Drug Development.
This article generally includes the pharmacological profile review of some chiral drugs and the aspects by which the single enantiomer can be of significant importance as compared to the racemic mixture of the drug. This can be achieved either by assuaging the side effects or toxic effects; or by the potentiated activity of the single enantiomer. Resolution deals with the separation of racemic compounds which shows up the credibility to obtain the desired enantiomeric properties. As isomers vary in their pharmacokinetic and pharmacodynamic profiles, chiral drugs have showcased considerable importance in the drug developmen...
Source: Current Drug Discovery Technologies - May 1, 2019 Category: Drugs & Pharmacology Authors: Gandhi K, Shah U, Patel S Tags: Curr Drug Discov Technol Source Type: research

Hybrid design of isonicotinic acid hydrazide derivatives: machine learning studies, synthesis and biological evaluation of their anti-tuberculosis activity.
CONCLUSION: The newly identified compounds may represent a starting point for further development of therapies against Mtb. The developed models are available online at OCHEM http://ochem.eu/article/111066 and can be used to virtually screen for potential compounds with anti-TB activity. PMID: 30973110 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 11, 2019 Category: Drugs & Pharmacology Authors: Kovalishyn V, Hodyna D, Sinenko VO, Blagodatny V, Semenyuta I, Slivchuk SR, Brovarets V, Poda G, Metelytsia L Tags: Curr Drug Discov Technol Source Type: research

Photochemical /Photocytotoxicity studies of new tetrapyrrolic structures as potential candidates for cancer theranostics.
Abstract Detailed photochemical and photocytotoxicity studies of two new porphyrins: 5,10,15,20-meso-tetrakis-(4-acetoxy-3-methoxyphenyl) porphyrin (P2.1) and 5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrin (P2.2) are reported, as potential candidates for theranostics. For powdered samples of P2.1 and P2.2 adsorbed onto a powdered biocompatible substrate, polyethylene glycol (PEG), a concentration study was performed, correlating the fluorescence emission intensity with sample absorption to determine the useful concentration range for photodynamic therapy of cancer (PDT) in which a...
Source: Current Drug Discovery Technologies - April 10, 2019 Category: Drugs & Pharmacology Authors: Ferreira LFV, Machado IF, Gama A, Socoteanu RP, Boscencu R, Manda G, Calhelha RC, Ferreira ICFR Tags: Curr Drug Discov Technol Source Type: research

Design, Synthesis and Anticancer Activity of Site Specific Short Chain Cationic Peptide.
Abstract In spite of current progress in treatment methods, cancer is a major source of morbidity and death rate all over the world. Traditional chemotherapeutic agents aim to divide cancerous cells, are often associated with deleterious side effects to healthy cells and tissues. Host defense peptides Cecropin A and B obtained from insects are capable to lyses various types of human cancer cells at peptide concentrations which are not fatal to normal eukaryotic cells. In the present work we have designed short chain α-helical linear and cyclic peptide from cecropin A having same cationic charge, hydrophobici...
Source: Current Drug Discovery Technologies - April 2, 2019 Category: Drugs & Pharmacology Authors: Sharma RD, Jain J, Khosa RL Tags: Curr Drug Discov Technol Source Type: research

Virtual structural similarity elucidates bioactivity of Fenchone: Enriched phytochemical in fennel essential oil.
CONCLUSION: To best of our knowledge this is first report which use structural similarity searching to explore biological activities of Fenchone. PMID: 30907324 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 21, 2019 Category: Drugs & Pharmacology Authors: Singh S, Gupta P, Gupta J Tags: Curr Drug Discov Technol Source Type: research

Biological Significance of Imidazole-Based Analogues in New Drug Development.
Abstract In the field of heterocyclic medicinal chemistry, especially five membered ring structures containing nitrogen atom, imidazole core is an imperative aromatic heterocycle which is usually present in naturally occurring products and synthetic bioactive molecules. Occurrence of imidazole moiety in therapeutic compounds may be beneficial in terms of improving water soluble properties due to its two nitrogen atoms which leads to the creation of hydrogen bonds. The imidazole nucleus has also been recognized as an important isostere of triazole, pyrazole, thiazole, tetrazole, oxazole, amide etc. for the purpose ...
Source: Current Drug Discovery Technologies - March 20, 2019 Category: Drugs & Pharmacology Authors: Chopra PN, Sahu JK Tags: Curr Drug Discov Technol Source Type: research

Novel Cinnamic Acid Derivatives as Potential PPAR δ Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies.
Novel Cinnamic Acid Derivatives as Potential PPARδ Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies. Curr Drug Discov Technol. 2019 Mar 14;: Authors: Chauhan A, Grewal AS, Pandita D, Lather V Abstract Peroxisome proliferator-activated receptor (PPAR) δ is expressed universally in the entire tissues, particularly in those concerned with the lipid metabolism. PPAR δ stimulation alters body's energy fuel preference to fat from glucose and shows up as an emerging pharmacological target for the treatment of metabolic disorders. A new series of cinnamic ac...
Source: Current Drug Discovery Technologies - March 14, 2019 Category: Drugs & Pharmacology Authors: Chauhan A, Grewal AS, Pandita D, Lather V Tags: Curr Drug Discov Technol Source Type: research

Structure based drug design and molecular docking studies of anti-cancer molecules paclitaxel, etoposide and topotecan using Novel ligands.
In this study,computer aided drug designing approach was applied to predict the suitable docking site in target protein and the interaction of tubulin protein with paclitaxel, etoposide and topotecan was explored by molecular docking using Schrödinger software. Docking score and glide energy were determined with ligands to validate their anticancer properties in order to reduce experimental efforts of studying animal model. The results indicate that etoposide is the best drug for tubulin with a docking score of -4.916 and glide energy of -46.470cal/mol. PMID: 30848204 [PubMed - as supplied by publisher] (Source: ...
Source: Current Drug Discovery Technologies - March 6, 2019 Category: Drugs & Pharmacology Authors: Yadav M, Dhagat S, Eswari JS Tags: Curr Drug Discov Technol Source Type: research

Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR.
Abstract Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. Development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria Although the "pioneering strategy" of discovering co...
Source: Current Drug Discovery Technologies - March 4, 2019 Category: Drugs & Pharmacology Authors: Moo CL, Yang SK, Yusoff K, Ajat M, Thomas W, Abushelaibi A, Lim SH, Lai KS Tags: Curr Drug Discov Technol Source Type: research

Harnessing Metal Homeostasis Offers Novel and Promising Targets Against Candida Albicans.
Abstract Fungal infections, particularly of Candida species, which are the commensal organisms of human, are one of the major debilitating diseases in immunocompromised patients. The limited number of antifungal drugs available to treat Candida infections, with concomitant increasing incidence of multidrug resistant (MDR),strains, further worsens the therapeutic options. Thus, there is an urgent need for the better understanding of MDR mechanisms, and their reversal, by employing new strategies to increase the efficacy and safety profiles of currently used therapies against the most prevalent human fungal pathogen...
Source: Current Drug Discovery Technologies - February 27, 2019 Category: Drugs & Pharmacology Authors: Hameed S, Hans S, Singh S, Fatima Z Tags: Curr Drug Discov Technol Source Type: research

The effect of resveratrol dose and duration of treatment on blood pressure in patients with cardiovascular disorders: A systematic review.
CONCLUSION: Resveratrol appears to have anti-hypertensive effects, depending on the dose and duration of treatment. Researchers attribute one of the important blood pressure reducing mechanisms of resveratrol to increasing levels of NO. Based on the results of this systematic review, it is suggested that more clinical studies be conducted to find the appropriate dose and duration of treatment. PMID: 30813878 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 25, 2019 Category: Drugs & Pharmacology Authors: Dorri Mashhadi F, Salari R, Ghorbanzadeh H Tags: Curr Drug Discov Technol Source Type: research

Long-term stabilization of aqueous doxycycline formulations, in mucoadhesive hydrogels for treatment of oral mucosal conditions.
In conclusion, it is possible to prevent doxycycline from both oxidation and epimerization in an aqueous formulation, for up to 5 years. PMID: 30806319 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 22, 2019 Category: Drugs & Pharmacology Authors: Reddy Patlolla VG, Holbrook WP, Gizurarson S, Kristmundsdottir T Tags: Curr Drug Discov Technol Source Type: research

In silico Inhibition of BACE-1 by Selective Phytochemicals as Novel Potential Inhibitors: Molecular Docking and DFT Studies.
CONCLUSION: Out of seven phytochemicals, four are from plant Glycyrrhiza glabra i.e. Shinflavanone, Glabrolide, Glabrol and PrenyllicoflavoneA, one from Huperzia serrate i.e. Macleanine, one from Uncaria rhynchophylla i.e. 3a-dihydro-cadambine and another one is VolvalerelactoneB from plant Valeriana-officinalis. It is concluded that these phytochemicals are candidate for drug/inhibitor against BACE-1, and can be administered to humans after experimental validation through in vitro and in vivo trials. PMID: 30767744 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 14, 2019 Category: Drugs & Pharmacology Authors: Arif N, Subhani A, Hussain W, Rasool N Tags: Curr Drug Discov Technol Source Type: research

Using PBPK Modeling to Predict Drug Exposure and Support Dosage Adjustments in Patients With Renal Impairment: An Example With Lamivudine.
Abstract BACKGROUND: Lamivudine is a nucleoside reverse transcriptase inhibitor used to treat HIV and hepatitis B. It is primarily cleared by the kidney with renal secretion mediated by OCT2 and MATE. OBJECTIVE: To use PBPK modeling to assess the impact of renal impairment on lamivudine pharmacokinetics using the Simcyp® Simulator. METHODS: The model incorporated the Simcyp® Mechanistic Kidney Model option to predict renal disposition. The model was initially verified using the Simcyp® Healthy Volunteer population. Two discrete patient populations were then created for moderate (GFR 10-40 mL/min) and severe (GFR
Source: Current Drug Discovery Technologies - February 14, 2019 Category: Drugs & Pharmacology Authors: Shah K, Fischetti B, Cha A, Taft DR Tags: Curr Drug Discov Technol Source Type: research

In vitro protective effect of ascorbic acid against antibiotic-induced hepatotoxicity.
CONCLUSION: Obtained data suggests that consumption of vitamin C or vitamin C rich food like citrus fruits or green leafy vegetables equivalent to 3g/day during antibiotic treatment, perhaps put down the risk of liver toxicity to a greater extent. PMID: 30714529 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - February 4, 2019 Category: Drugs & Pharmacology Authors: Simon V, Sreerag KV, Sasikumar R, Kanthlal SK Tags: Curr Drug Discov Technol Source Type: research

Cinnamaldehyde Analogs: Docking Based Optimization, COX-2 Inhibitory in vivo and in vitro Studies.
Abstract The research work aims to investigate Schiff bases of Cinnamaldehyde as biologically potent analogs. In the past decade CADD has emerged as a rational approach in drug development so with the help molecular docking approach we planned to perform virtual screening of the designed data set of Schiff bases. This will be helpful to put some light on the drug receptor interactions required for anti-inflammatory activity. For carrying out virtual screening of the developed Schiff base data set, AutoDock 4.0 was used. Compounds V2A44, V2A55, V2A76, V2A82, V2A119, V2A141 and V2A142 has shown highest binding energ...
Source: Current Drug Discovery Technologies - January 25, 2019 Category: Drugs & Pharmacology Authors: Patil VM, Anand P, Bhardwaj M, Masand N Tags: Curr Drug Discov Technol Source Type: research

Therapeutic aspects of Squill; an evidence-based review.
Abstract From ancient times, medicinal plants have been usually utilized to treat many disorders, but today, interest in these herbs is again aroused, because of their fewer side effects and low-cost. In traditional medicine, for many diseases, various medicinal herbs have been suggested so far. Drimia maritime, also named squill, is an important medicinal plant for the treatment of many diseases, especially respiratory diseases. In the current evidence-based study, we conducted a review of the general characteristics, ingredients, administration form, and side effects of squill in traditional medicine. For this p...
Source: Current Drug Discovery Technologies - January 25, 2019 Category: Drugs & Pharmacology Authors: Saket K, Afshari JT, Saburi E, Yousefi M, Salari R Tags: Curr Drug Discov Technol Source Type: research

The Role of Anthocyanins in Drug Discovery: Recent Developments.
Abstract Natural compounds have always played a key role in drug discovery. Anthocyanins are secondary metabolites belonging to the flavonoids family responsible for the purple, blue, and red colour of many vegetables and fruits. These phytochemicals have attracted the interest of researchers for their important implications in human health and for their use as natural colorants. Many in vitro and in vivo studies demonstrated the potential effects of anthocyanins and anthocyanins-rich foods in the prevention and/or treatment of diabetes, cancer, and cardiovascular and neurodegenerative diseases. This review report...
Source: Current Drug Discovery Technologies - January 25, 2019 Category: Drugs & Pharmacology Authors: Bonesi M, Leporini M, Tenuta MC, Tundis R Tags: Curr Drug Discov Technol Source Type: research

Antimicrobial Activity of Agarwood Oil against Multiple-Drug-Resistant (MDR) Microbes of Clinical, Food and Environmental Origin.
CONCLUSION: The study concluded that MDR and AO resistance had similar trend and AO may not be seen as a good antimicrobial agent against MDR strains. PMID: 30686261 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - January 25, 2019 Category: Drugs & Pharmacology Authors: Singh BR, Sinha DK, Kumar ORV, Vadhana P, Bhardwaj M, Saraf A, Dubey S, Pawde AM, De UK, Gupta VK Tags: Curr Drug Discov Technol Source Type: research

An herbal H2 blocker in melasma treatment.
CONCLUSION: Herbal H2 blockers should be noted in melasma treatment along with the topical drugs. PMID: 30666910 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - January 21, 2019 Category: Drugs & Pharmacology Authors: Mahjour M, Khoushabi A Tags: Curr Drug Discov Technol Source Type: research

From Target identification to Drug Development in Space: Using the Microgravity Assist.
Abstract The unique nature of microgravity encountered in space provides an opportunity for drug discovery and development that cannot be replicated on Earth. From the production of superior protein crystals to the identification and validation of new drug targets to microarray analyses of transcripts attenuated by microgravity, there are numerous examples which demonstrate the benefit of exploiting the space environment. Moreover, studies conducted on Space Shuttle missions, the International Space Station and other craft have had direct benefit for drug development programmes such as those directed against reduc...
Source: Current Drug Discovery Technologies - January 12, 2019 Category: Drugs & Pharmacology Authors: Braddock M Tags: Curr Drug Discov Technol Source Type: research

Structure-Activity Relationships of Cytotoxic Lactones as Inhibitors and Mechanisms of Action.
CONCLUSION: Likely action mechanisms for lactones are argued with a diversity of functional groups in the lactone annulus, including artemisinin with its uncommon macrocycle characteristic, 1,2,4 trioxane cycle (pharmacophoric peroxide linkage -O1-O2- in endoperoxide ring), which results the foundation for its sole antimalarial potency. PMID: 30621564 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 31, 2018 Category: Drugs & Pharmacology Authors: Torrens F, Castellano G Tags: Curr Drug Discov Technol Source Type: research

Novel approaches to anti-atherosclerotic therapy: Cell-based models and herbal preparations (Review of our own data).
Abstract Atherosclerosis is a chronic arterial disease characterized by vascular inflammation, accumulation of lipids in the arterial wall, and formation and growth of atherosclerotic plaques followed by ischemia. In subclinical atherosclerosis, cholesterol retention in subendothelial cells leads to induction of local inflammation, generation of foam cells and lesion formation, followed by a chain of other pathogenic events. Atherosclerotic progression can frequently be fatal, since plaque rupture may lead to thrombosis and acute events, such as myocardial infarction, stroke and sudden death. Traditional anti-athe...
Source: Current Drug Discovery Technologies - December 31, 2018 Category: Drugs & Pharmacology Authors: Orekhov AN, Grechko AV, Romanenko EB, Zhang D, Chistiakov DA Tags: Curr Drug Discov Technol Source Type: research

PCSK9 inhibitors and cardiovascular disease: impact on cardiovascular outcomes.
Abstract Cardiovascular disease (CAD) remains the leading cause of morbidity and mortality in the western world. Hypolipidemic drugs have long been used for the primary and secondary prevention of heart disease. However, the high frequency of recurrent events in patients despite on hypolipidemic therapy has increased the need for new more targeted therapeutic approaches. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are monoclonal antibodies to the PCSK9 gene and represent a new class of drugs that have been shown to further decrease LDL-C when administered as a monotherapy or in combination wit...
Source: Current Drug Discovery Technologies - December 10, 2018 Category: Drugs & Pharmacology Authors: Farmaki P, Damaskos C, Garbis N, Garbi A, Savvanis S, Diamantis E Tags: Curr Drug Discov Technol Source Type: research

Efficacy of β-D-mannuronic acid [M2000] on pro-apoptotic process and inflammatory related molecules NFҡB, IL-8 and Cd49d using healthy donor PBMC.
Efficacy of β-D-mannuronic acid [M2000] on pro-apoptotic process and inflammatory related molecules NFҡB, IL-8 and Cd49d using healthy donor PBMC. Curr Drug Discov Technol. 2018 Nov 09;: Authors: Khalatbari A, Mahdavi M, Jafarnezhad F, Afraei S, Zavareh FT, Aghazadeh Z, Ghaderi A, Mirshafiey A Abstract This investigation evaluates the pro-apoptotic and anti-inflammatory effects of β-D-mannuronic acid [M2000] compared to diclofenac, based on gene expression involved in apoptosis and inflammation process [including Bcl2, NFκB, IL-8 and Cd49d] in peripheral blood mononuclear cells [PBMCs...
Source: Current Drug Discovery Technologies - November 9, 2018 Category: Drugs & Pharmacology Authors: Khalatbari A, Mahdavi M, Jafarnezhad F, Afraei S, Zavareh FT, Aghazadeh Z, Ghaderi A, Mirshafiey A Tags: Curr Drug Discov Technol Source Type: research

Design, Synthesis and Pharmacological evalution of 1,3,4-Oxadiazole Derivatives As Collapsin Response Mediator Protein 1 (CRMP 1) Inhibitors.
CONCLUSION: Amongst the hybrids, p-nitro substituted derivative (5a) and p-chloro substituted (5f) showed highest activity against human lung cancer cell line NCI-H2066 by TRAP assay. PMID: 30398117 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 5, 2018 Category: Drugs & Pharmacology Authors: Panchal II, Rajput R, Patel AD Tags: Curr Drug Discov Technol Source Type: research

Herbal Products Regulations in a few countries - A brief Overview.
Abstract Herbal medicines have been used by mankind from time immemorial. Moreover, many modern medicines are originated from plant sources. In earlier days, patients were dependent on herbs for treatment and well-being. However, due to advent of industrial revolution and modern science, scenario of treating diseases has changed over a period of time. Majority of patients started preferring allopathy medicines due to their several advantages over herbal medicines. However, due to long term treatment by allopathic medicines for chronic diseases have led to side effects, hence, patients are now drifting back to the ...
Source: Current Drug Discovery Technologies - November 4, 2018 Category: Drugs & Pharmacology Authors: Bhat BB, Udupa N, Sreedhar D Tags: Curr Drug Discov Technol Source Type: research

Hydroalcoholic extract of Cuscuta epithymum enhances pentobarbital-induced sleep: possible involvement of GABAergic system.
CONCLUSION: The results of the present study indicate the HAE and NHF has significant sedative-hypnotic effects in mice without major toxic effect and that the benzodiazepine receptors are involved in the sedative-hypnotic effects of this plant. PMID: 30394211 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 4, 2018 Category: Drugs & Pharmacology Authors: Forouzanfar F, Vahedi MM, Aghaei A, Rakhshandeh H Tags: Curr Drug Discov Technol Source Type: research

In silico analysis and molecular docking studies of novel 4-Amino-3-(isoquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine derivatives as Dual PI3K/mTOR inhibitors.
Abstract mTORC1/ PI3K control multiple anabolic pathways, including protein synthesis, ribosome production, lipogenesis, and nucleotide synthesis, all of which are important for cell and tissue growth.Sapanisertib and Dactolisib inhibit PI3K/AKT/mTOR pathway, an important signalling pathway for many cellular functions such as growth control, metabolism and translation initiation.Dactolisib contain quinolin-3-yl-2,3-dihydroimidazo[4,5-c]quinolin scaffold and Sapanisertib contain benzo[d]oxazol-5-yl-1-ethyl-1H-pyrazolo[3,4-d]pyrimidinnucleous. From the reference of both of drug novel series of 4-Amino-3-(isoquinolin...
Source: Current Drug Discovery Technologies - November 2, 2018 Category: Drugs & Pharmacology Authors: Panchal II, Badeliya SN, Patel R Tags: Curr Drug Discov Technol Source Type: research

Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial.
Abstract BACKGROUND: The aim of this study was to evaluate the efficacy of the herbal tea based on Foeniculum vulgare, on inducing regular bleeding in women with oligomenorrhea and secondary amenorrhea(oligo/amenorrhea). METHODS: Forty women aged 18- 40 with oligo/amenorrhea were enrolled in this randomized controlled clinical trial and were allocated to two groups equally. The women in the first group were treated by Fomentex (Foeniculum vulgare / Mentha longifolia / Vitex agnus-castus) herbal tea 11.2 g/day in 2 divided doses for 2 weeks and the second group were treated by medroxy progesterone acetate (MP)...
Source: Current Drug Discovery Technologies - October 29, 2018 Category: Drugs & Pharmacology Authors: Falahat F, Ayatiafin S, Jarahi L, Mokaberinejad R, Rakhshandeh H, Feyzabadi Z, Tavakkoli M Tags: Curr Drug Discov Technol Source Type: research

A review article about some herbs affecting vitiligo based on Avicenna's Canon.
CONCLUSION: The researchers suggest conducting clinical trials on the patients with vitiligo based on the Canon besides the conventional techniques to obtain a better result in the treatment. PMID: 30332966 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 16, 2018 Category: Drugs & Pharmacology Authors: Mahjour M, Khoushabi A Tags: Curr Drug Discov Technol Source Type: research

Docking Studies of Curcumin and Analogues with Various Phosphodiesterase 4 Subtypes.
CONCLUSIONS: Curcumin and analogues have moderate to strong affinity towards all PDE4 subtypes and have evident selectivity towards PDE4B. Oxygen atom of methoxy groups plays a key role in protein binding and any alterations could interfere with the protein binding. Tetrahydropyran side chain and heterocyclic rings are also suggested to be helpful in protein binding. PMID: 30332967 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 16, 2018 Category: Drugs & Pharmacology Authors: Yi YX, Gaurav A Tags: Curr Drug Discov Technol Source Type: research