Effects of Nanomolar Methylmercury on developing Human Neural Stem Cells and Zebrafish Embryo
This study shows that the ZF model was more susceptible than NSC to MeHg neurotoxicity. The combination of different models has improved the understanding of the underlying mechanisms of toxicity and possible compensatory mechanisms at the cellular and organismal level.PMID:38663761 | DOI:10.1016/j.fct.2024.114684 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: M ónica Torres-Ruiz Mercedes de Alba Gonzalez Ana I Ca ñas Portilla Raquel Coronel Isabel Liste M ª Carmen González-Caballero Source Type: research
Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study
Food Chem Toxicol. 2024 Apr 23:114686. doi: 10.1016/j.fct.2024.114686. Online ahead of print.ABSTRACTDibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), two common types of phthalates, are known to cause reproductive and developmental toxicity in animals and humans. The reference doses (RfD) of DBP and DEHP should be determined by sensitive endpoints. We here aimed to identify sensitive endpoints for DBP- and DEHP-induced such toxicity using published literatures. By examining the impacts of maternal exposure to DBP or DEHP on anogenital distance (AGD) and semen quality of offspring, we discovered that DBP or DE...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Kai Li Yiping Zhang Ludi Li Kanglong Cui Yingzi Li Chunying Li Yufei Dai Wusheng Xiao Qi Wang Source Type: research
Retinal toxicity of heavy metals and its involvement into retinal pathology
The objective of the present review is to discuss epidemiological evidence demonstrating the association between toxic metal (Cd, Pb, Hg, As, Sn, Ti, Tl) exposure and retinal pathology, along with the potential underlying molecular mechanisms. Epidemiological studies demonstrate that Cd, and to a lesser extent Pb exposure, are associated with age-related macular degeneration (AMD), while the existing evidence on the levels of these metals in patients with diabetic retinopathy is scarce. Epidemiological data on the association between other toxic metals and metalloids including mercury (Hg) and arsenic (As), are limited. Cl...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Michael Aschner Anatoly V Skalny Monica M B Paoliello Margarita N Tinkova Airton C Martins Abel Santamaria Eunsook Lee Joao Bt Rocha Sandra Hp Farsky Alexey A Tinkov Source Type: research
Network toxicology and molecular docking for the toxicity analysis of food contaminants: A case of Aflatoxin B < sub > 1 < /sub >
Food Chem Toxicol. 2024 Apr 23:114687. doi: 10.1016/j.fct.2024.114687. Online ahead of print.ABSTRACTThe present study aims to promote network toxicology and molecular docking strategies for the efficient evaluation of the toxicity of food contaminants. With the example of liver injury induced by the food contaminant Aflatoxin B1(AFB1), this study effectively investigated the putative toxicity of food contaminants and the potentially molecular mechanisms. The study found that AFB1 regulates multiple signalling pathways by modulating core targets such as AKT1, BCL2, TNF, CASP3, SRC, and EGFR. These pathways encompass Pathwa...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Zi-Yong Chu Xue-Jiao Zi Source Type: research
Butylated hydroxyanisole induces vascular endothelial injury via TFEB-mediated degradation of GPX4 and FTH1
In conclusion, BHA degrades GPX4, xCT, and FTH1 through activation of the TFEB-mediated lysosomal pathway and promotes ferroptosis, ultimately leading to vascular endothelial cell injury.PMID:38657941 | DOI:10.1016/j.fct.2024.114682 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 24, 2024 Category: Food Science Authors: Yufei Zhan Yazhuo Zhang Source Type: research
Prenatal acetaminophen exposure and the developing ovary: time, dose, and course consequences for fetal mice
In this study, we established a PAcE Kunming mouse model at different time (middle pregnancy and third trimester), doses (low, middle, high) and courses (single or multi-) to systematically investigate their effects on fetal ovarian development. The findings indicated PAcE affected ovarian development, reduced fetal ovarian oocyte number and inhibited cell proliferation. A reduction in mRNA expression was observed for genes associated with oocyte markers (NOBOX and Figlα), follicular development markers (BMP15 and GDF9), and pre-granulosa cell steroid synthase (SF1 and StAR). Notably, exposure in middle pregnancy, high do...
Source: Food and Chemical Toxicology - April 24, 2024 Category: Food Science Authors: Tiancheng Wu Jing Huang Yating Li Yu Guo Hui Wang Yuanzhen Zhang Source Type: research
SWATH-MS reveals that Bisphenol A and its analogs regulate pathways leading to disruption in Insulin signaling and fatty acid metabolism
This study has important implications in addressing health concerns related to EDCs. Given that the analogs of BPA are considered alternatives to BPA, the findings of this study suggest they are equally potent in altering fatty acid metabolism and inducing insulin resistance.PMID:38653447 | DOI:10.1016/j.fct.2024.114667 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 23, 2024 Category: Food Science Authors: Shabda Kulsange Monika Sharma Babasaheb Sonawane Meera R Jaiswal Mahesh Kulkarni B Santhakumari Source Type: research
SWATH-MS reveals that Bisphenol A and its analogs regulate pathways leading to disruption in Insulin signaling and fatty acid metabolism
This study has important implications in addressing health concerns related to EDCs. Given that the analogs of BPA are considered alternatives to BPA, the findings of this study suggest they are equally potent in altering fatty acid metabolism and inducing insulin resistance.PMID:38653447 | DOI:10.1016/j.fct.2024.114667 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 23, 2024 Category: Food Science Authors: Shabda Kulsange Monika Sharma Babasaheb Sonawane Meera R Jaiswal Mahesh Kulkarni B Santhakumari Source Type: research
Hexafluoropropylene oxide trimer acid (HFPO-TA) exerts cytotoxic effects on Leydig cells via the ER stress/JNK/ β-TrCP/Mcl-1 axis
In this study, TM3 mouse Leydig cells were used as the main model to evaluate the cytotoxicity of HFPO-TA in vitro. HFPO-TA inhibited the viability and expression of multiple biomarkers of Leydig cells. HFPO-TA also induced Leydig cell apoptosis in a caspase-dependent manner. Moreover, HFPO-TA induced the ubiquitination and degradation of Mcl-1 in a β-TrCP-dependent manner. Further investigations showed that HFPO-TA treatment led to the upregulation of ROS, which activated the ER stress/JNK/β-TrCP axis in Leydig cells. Overall, our study provides novel insights into the cytotoxic effects of HFPO-TA on the male reproducti...
Source: Food and Chemical Toxicology - April 21, 2024 Category: Food Science Authors: Hongping Shen Lingling Fu Yili Cai Keqi Zhu Xueqin Chen Source Type: research
Elemental Composition of Toxic and Essential Elements in Rice-Based Baby Foods from the United States and other Countries: A Probabilistic Risk Analysis
Food Chem Toxicol. 2024 Apr 17:114677. doi: 10.1016/j.fct.2024.114677. Online ahead of print.ABSTRACTConsumption of rice-based foods provides essential nutrients required for infants and toddlers' growth. However, they could contain toxic and excess essential elements that may affect human health. The study aims to determine the composition of rice-based baby foods in the USA and outside and conduct a multiple-life stages probabilistic exposure and risk assessment of toxic and essential elements in children. Elemental concentrations were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in thirty-three r...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Mom TatahMentan Syprose Nyachoti Tewodros Rango Godebo Source Type: research
Safety evaluation of organochlorine pesticides and polybrominated diphenyl ethers in imported canned fish in Nigeria
Food Chem Toxicol. 2024 Apr 17:114676. doi: 10.1016/j.fct.2024.114676. Online ahead of print.ABSTRACTOrganochlorine pesticide (OCP) and polybrominated diphenyl ether (PBDE) concentrations were measured in thirty popular brands of imported canned fish (mackerel, sardines, and tuna) in Nigeria to ascertain potential threats to humans arising from their consumption. The Σ20 OCP concentrations in mackerel ranged from 0.47 to 7.36 ng g-1, while those of tuna and sardines varied from 1.06 to 2.19 and 0.11 to 12.7 ng g-1, respectively. The Σ39 PBDE concentrations in mackerel varied from 0.06 to 4.21 ng g-1, while those of tuna ...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Chukwujindu M A Iwegbue Obehi L Afolabi Ijeoma F Ogwu Godwin E Nwajei Bice S Martincigh Source Type: research
Investigation of the in vitro toxic effects induced by real-time aerosol of electronic cigarette solvents using microfluidic chips
This study constructed an original real-time aerosol exposure system, centered around a self-designed microfluidic bionic-lung chip, to assess the biological effects following exposure to aerosols from different solvents (PG, PG/VG mixture alone and PG/VG mixture in combination with nicotine) on BEAS-2B cells. The study aimed to investigate the impact of aerosols from different solvents on gene expression profiles, intracellular biomarkers (i.e., reactive oxygen species content, nitric oxide content, and caspase-3/7 activity), and extracellular biomarkers (i.e., IL-6, IL-8, TNF-α, and malondialdehyde) of BEAS-2B cells on-...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Zezhi Li Xiang Li Boyang Feng Junwei Zhao Kejian Liu Fuwei Xie Jianping Xie Source Type: research
Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3
Food Chem Toxicol. 2024 Apr 17;188:114665. doi: 10.1016/j.fct.2024.114665. Online ahead of print.ABSTRACTAmanita phalloides is one of the deadliest mushrooms worldwide, causing most fatal cases of mushroom poisoning. Among the poisonous substances of Amanita phalloides, amanitins are the most lethal toxins to humans. Currently, there are no specific antidotes available for managing amanitin poisoning and treatments are lack of efficacy. Amanitin mainly causes severe injuries to specific organs, such as the liver, stomach, and kidney, whereas the lung, heart, and brain are hardly affected. However, the molecular mechanism o...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Mengqiang Gong Zhi Li Hua Xu Bo Ma Pengxia Gao Lili Wang Junkai Li Qinglai Wu Jianfeng Wu Jianwei Xie Source Type: research
Update to RIFM fragrance ingredient safety assessment, hexanoic acid, 4-methyl-, CAS Registry Number 1561-11-1
Food Chem Toxicol. 2024 Apr 16:114661. doi: 10.1016/j.fct.2024.114661. Online ahead of print.NO ABSTRACTPMID:38636594 | DOI:10.1016/j.fct.2024.114661 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, 4-ethyloctanoic acid, CAS registry number 16493-80-4
Food Chem Toxicol. 2024 Apr 16;189 Suppl 1:114662. doi: 10.1016/j.fct.2024.114662. Online ahead of print.NO ABSTRACTPMID:38636595 | DOI:10.1016/j.fct.2024.114662 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
