Gestational dibutyl phthalate exposure impairs primordial folliculogenesis in mice through autophagy activation and NOTCH2 signal interruption
In this study, maternal exposure to DBP in gestation disrupted germ-cell cyst breakdown and primordial follicle assembly in foetal ovary, impairing female fertility in adulthood. Subsequently, altered autophagic flux with autophagosome accumulation was observed in DBP-exposed ovaries carrying CAG-RFP-EGFP-LC3 reporter genes, whereas autophagy inhibition by 3-methyladenine attenuated the impact of DBP on primordial folliculogenesis. Moreover, DBP exposure reduced the expression of NOTCH2 intracellular domain (NICD2) and decreased interactions between NICD2 and Beclin-l. NICD2 was observed within the autophagosomes in DBP-ex...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Yan Zhang Yiji Wan Xinyi Mu Rufei Gao Yanqing Geng Xuemei Chen Fangfang Li Junlin He Source Type: research
Enhancing the neuroprotective effect of squid outer skin astaxanthin against rotenone-induced neurotoxicity in in-vitro model for Parkinson's disease
Food Chem Toxicol. 2023 Jun 3:113846. doi: 10.1016/j.fct.2023.113846. Online ahead of print.ABSTRACTRotenone is a widely used organic pesticide that induces neurotoxicity via inhibition of mitochondrial complex I and oxidative stress actions for the most of dopaminergic neurons as that occurring in Parkinsonism disease (PD). Astaxanthin (ASX) is a natural pigment (carotenoids) and a potent therapeutic compound due to its antioxidant and anti-inflammatory properties. The commercially important cephalopod Doryteuthis singhalensis is widely distributed in tropical and subtropical waters in World Ocean. D. singhalensis is an i...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Veeruraj Anguchamy Muthuvel Arumugam Source Type: research
Soluble thrombomodulin alleviates Diquat-induced acute kidney injury by inhibiting the HMGB1/I κBα/NF-κB signalling pathway
Food Chem Toxicol. 2023 Jun 3:113871. doi: 10.1016/j.fct.2023.113871. Online ahead of print.ABSTRACTOur research aimed to investigate whether soluble thrombomodulin (sTM) relieved Diquat (DQ)-induced acute kidney injury (AKI) via HMGB1/IκBα/NF-κB signaling pathways. An AKI rat model was constructed using DQ. Pathological changes in renal tissue were detected by HE and Masson staining. Gene expression was determined using qRT-PCR, IHC, and western blotting. Cell activity and apoptosis were analysed using CCK-8 and Flow cytometry, respectively. An abnormal kidney structure was observed in DQ rats. The levels of blood urea...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Shaofang Huang Shirong Lin Shengliang Zhou Ziyan Huang Yang Li Shiwen Liu Risheng Liu Xurui Luo Jiawei Li Jibin Yang Zheng Yuan Source Type: research
Gestational dibutyl phthalate exposure impairs primordial folliculogenesis in mice through autophagy activation and NOTCH2 signal interruption
In this study, maternal exposure to DBP in gestation disrupted germ-cell cyst breakdown and primordial follicle assembly in foetal ovary, impairing female fertility in adulthood. Subsequently, altered autophagic flux with autophagosome accumulation was observed in DBP-exposed ovaries carrying CAG-RFP-EGFP-LC3 reporter genes, whereas autophagy inhibition by 3-methyladenine attenuated the impact of DBP on primordial folliculogenesis. Moreover, DBP exposure reduced the expression of NOTCH2 intracellular domain (NICD2) and decreased interactions between NICD2 and Beclin-l. NICD2 was observed within the autophagosomes in DBP-ex...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Yan Zhang Yiji Wan Xinyi Mu Rufei Gao Yanqing Geng Xuemei Chen Fangfang Li Junlin He Source Type: research
Enhancing the neuroprotective effect of squid outer skin astaxanthin against rotenone-induced neurotoxicity in in-vitro model for Parkinson's disease
Food Chem Toxicol. 2023 Jun 3:113846. doi: 10.1016/j.fct.2023.113846. Online ahead of print.ABSTRACTRotenone is a widely used organic pesticide that induces neurotoxicity via inhibition of mitochondrial complex I and oxidative stress actions for the most of dopaminergic neurons as that occurring in Parkinsonism disease (PD). Astaxanthin (ASX) is a natural pigment (carotenoids) and a potent therapeutic compound due to its antioxidant and anti-inflammatory properties. The commercially important cephalopod Doryteuthis singhalensis is widely distributed in tropical and subtropical waters in World Ocean. D. singhalensis is an i...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Veeruraj Anguchamy Muthuvel Arumugam Source Type: research
Soluble thrombomodulin alleviates Diquat-induced acute kidney injury by inhibiting the HMGB1/I κBα/NF-κB signalling pathway
Food Chem Toxicol. 2023 Jun 3:113871. doi: 10.1016/j.fct.2023.113871. Online ahead of print.ABSTRACTOur research aimed to investigate whether soluble thrombomodulin (sTM) relieved Diquat (DQ)-induced acute kidney injury (AKI) via HMGB1/IκBα/NF-κB signaling pathways. An AKI rat model was constructed using DQ. Pathological changes in renal tissue were detected by HE and Masson staining. Gene expression was determined using qRT-PCR, IHC, and western blotting. Cell activity and apoptosis were analysed using CCK-8 and Flow cytometry, respectively. An abnormal kidney structure was observed in DQ rats. The levels of blood urea...
Source: Food and Chemical Toxicology - June 5, 2023 Category: Food Science Authors: Shaofang Huang Shirong Lin Shengliang Zhou Ziyan Huang Yang Li Shiwen Liu Risheng Liu Xurui Luo Jiawei Li Jibin Yang Zheng Yuan Source Type: research
A small animal model of NASH with progressive steatohepatitis -induced by fast food diet and alcohol in C57BL/6J mouse with high human pathophysiological proximity
Food Chem Toxicol. 2023 Jun 2:113851. doi: 10.1016/j.fct.2023.113851. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH) both can progress to end-stage liver disease (ESLD). No relevant animal models are available for studying the toxic consequences of concurrent fast food diet- and alcohol usage in fibrosing NASH. As a result, dependable and short-term In-vivo models capable of recapitulating human disease pathophysiology are required for deciphering mechanistic insights and preclinical drug discovery programs. The current study aims to develop a mouse model for progress...
Source: Food and Chemical Toxicology - June 4, 2023 Category: Food Science Authors: Raghu Rai Sharma Haroon Rashid Sheikh Tasduq Abdullah Source Type: research
Dietary exposure to cadmium from six common foods in the United States
Food Chem Toxicol. 2023 Jun 2:113873. doi: 10.1016/j.fct.2023.113873. Online ahead of print.ABSTRACTRecently, the United States (US) Food and Drug Administration (FDA) launched a Closer to Zero Action Plan to assess the risks of and develop action levels for certain heavy metals in food including cadmium (Cd). The problem of foodborne metal contamination has taken on new urgency, thanks in part to a 2021 US Congressional Report detailing high levels of metals found in infant food. Our risk assessment aids this FDA Action Plan by estimating the American population's Cd exposures in food, by age group and consumption pattern...
Source: Food and Chemical Toxicology - June 4, 2023 Category: Food Science Authors: Ashish Pokharel Felicia Wu Source Type: research
L-theanine attenuates porcine intestinal tight junction damage induced by LPS via p38 MAPK/NLRP3 signaling in IPEC-J2 cells
In conclusion, L-theanine could protect LPS-induced intestinal tight junction damage by inhibiting the activation of p38 MAPK-mediated NLRP3 inflammasome pathway.PMID:37271275 | DOI:10.1016/j.fct.2023.113870 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 4, 2023 Category: Food Science Authors: Xiaoling Chen Diaoyun Luo Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research
PIG-A gene mutation as a mutagenicity biomarker among coke oven workers
Food Chem Toxicol. 2023 Jun 2:113872. doi: 10.1016/j.fct.2023.113872. Online ahead of print.ABSTRACTPIG-A gene mutations can be detected in humans, and PIG-A assays can potentially predict the risk of exposure to carcinogens. However, extensive, population-based studies to validate this are lacking. We studied a cohort of occupational coke oven workers with chronic high exposure to carcinogenic polycyclic aromatic hydrocarbons, which are well-studied genotoxins classified by the IARC as carcinogenic to humans. Peripheral blood erythrocytes of workers were assessed for gene mutations using a PIG-A assay, and chromosome dama...
Source: Food and Chemical Toxicology - June 4, 2023 Category: Food Science Authors: Jing Xi Yiyi Cao Yanhua Wang Xinyue You Weiying Liu Ting Wang Jingjing Yin Junxiang Ma Zhenjie Wang Nan Wu Xinyu Zhang Huawei Duan Yang Luan Source Type: research
Melatonin alleviated fluoride-induced impairment of spermatogenesis and sperm maturation process via Interleukin-17A
This study aims to explore whether MLT can mitigate fluoride-induced male reproductive toxicity through IL-17A, and screen the potential targets. So the wild type and IL-17A knockout mice were employed and treated with sodium fluoride (100 mg/L) by drinking water and MLT (10 mg/kg.BW, intraperitoneal injection per two days starting from week 16) for 18 weeks. Bone F- concentrations, grade of dental damage, sperm quality, spermatogenic cells counts, histological morphology of testis and epididymis, and the mRNA expression of spermatogenesis and maturation, classical pyroptosis related and immune factor genes were detected r...
Source: Food and Chemical Toxicology - June 3, 2023 Category: Food Science Authors: Huifeng Luo Rongxiu Liu Yilin Lang Jinhui Zhao Cuicui Zhuang Jundong Wang Chen Liang Jianhai Zhang Source Type: research
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes
In conclusion, our novel findings shed new light on the functional roles of m6A modification in the expressional alternations of downstream transcripts caused by lead, providing an innovative molecular basis to explain Pb neurotoxicity.PMID:37269892 | DOI:10.1016/j.fct.2023.113821 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 3, 2023 Category: Food Science Authors: Shu Ai Danyang Li Xiaozhen Gu Yi Xu Yi Wang Hui-Li Wang Xiang-Tao Chen Source Type: research
Reno- and hepato-protective effect of allopurinol after renal ischemia/reperfusion injury: Crosstalk between xanthine oxidase and peroxisome proliferator-activated receptor gamma signaling
In conclusion, this study highlights the potential therapeutic value of ALP and suggests targeting XO-PPAR-γ pathway as a promising strategy for preventing I/R injury.PMID:37269893 | DOI:10.1016/j.fct.2023.113868 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 3, 2023 Category: Food Science Authors: Eman Soliman Shimaa Mustafa Elshazly Samar M Shewaikh Fatma El-Shaarawy Source Type: research
Intestinal microbiota regulates colonic inflammation in fluorosis mice by TLR/NF- κB pathway through short-chain fatty acids
In this study, 100 mg/L NaF exposure for 90 days significantly elevated the expressions of inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, TGF-β, and IL-10), and the levels of TLR4, TRAF6, Myd88, IKKβ, and NF-κB P65 in mouse colon, while the above factors were reduced in pseudo germ-free mice with fluorosis, hinting that disordered microbiota might play a more direct role in the development of colonic inflammation than fluoride. Fecal microbiota transplantation (FMT) lowered the levels of inflammatory factors and inactivated the TLR/NF-κB pathway in fluoride-exposed mice. In addition, supplementing short-chain fatt...
Source: Food and Chemical Toxicology - June 3, 2023 Category: Food Science Authors: Zhang Shaosan Taotao Zhao Yu Wang Jiahui Mi Jie Liu Xinyu Fan Ruiyan Niu Zilong Sun Source Type: research
Melatonin alleviated fluoride-induced impairment of spermatogenesis and sperm maturation process via Interleukin-17A
This study aims to explore whether MLT can mitigate fluoride-induced male reproductive toxicity through IL-17A, and screen the potential targets. So the wild type and IL-17A knockout mice were employed and treated with sodium fluoride (100 mg/L) by drinking water and MLT (10 mg/kg.BW, intraperitoneal injection per two days starting from week 16) for 18 weeks. Bone F- concentrations, grade of dental damage, sperm quality, spermatogenic cells counts, histological morphology of testis and epididymis, and the mRNA expression of spermatogenesis and maturation, classical pyroptosis related and immune factor genes were detected r...
Source: Food and Chemical Toxicology - June 3, 2023 Category: Food Science Authors: Huifeng Luo Rongxiu Liu Yilin Lang Jinhui Zhao Cuicui Zhuang Jundong Wang Chen Liang Jianhai Zhang Source Type: research
