Health Risk Assessment of Aflatoxin M1 in Infant Formula Milk in IR Iran.
In this study, two accurate, precise, selective and sensitive methods were developed for determining aflatoxin M1 (AFM1) in infant formula milk using immunoaffinity column clean-up followed by high performance liquid chromatography (HPLC) with fluorescence detection. The validated methods were used for determination of AFM1 in 29 samples of 6 different infant formula milk brands and the risk of AFM1 in infants aged zero to 6 months old was assessed using cancer risk, Margin of Exposure (MOE) and Hazard Index (HI). Only one sample (3.4%) was contaminated with AFM1. Although the results showed that MOE values for the mean an...
Source: Food and Chemical Toxicology - May 28, 2020 Category: Food Science Authors: Hooshfar S, Khosrokhavar R, Yazdanpanah H, Eslamizad S, Kobarfard F, Nazari F, Kokaraki V, Kokkinakis M, Goumenou M, Tsitsimpikou C, Tsatsakis A Tags: Food Chem Toxicol Source Type: research

Effects of 2-MCPD on oxidative stress in different organs of male mice.
Abstract 2-Monochloropropane-1,3-diol (2-MCPD) and its isomer 3-monochloropropane-1,2-diol (3-MCPD) are widespread food contaminants. 3-MCPD has been classified as a non-genotoxic carcinogen, whereas very limited toxicological data are available for 2-MCPD. Animal studies indicate that heart and skeletal muscle are target organs of 2-MCPD. Oxidative stress may play a role in this process, and the potential of 3-MCPD to induce oxidative stress in vivo has already been demonstrated. To investigate the potential of 2-MCPD to induce oxidative stress in vivo, a 28-day oral feeding study in male HOTT reporter mice was c...
Source: Food and Chemical Toxicology - May 28, 2020 Category: Food Science Authors: Schultrich K, Henderson CJ, Buhrke T, Braeuning A Tags: Food Chem Toxicol Source Type: research

Migration of volatile compounds from natural biomaterials and their safety evaluation as food contact materials.
L, Nerín C Abstract The concern for environmental conservation is increasing, and a very important factor to consider is the search for alternatives to the use of plastics in the food packaging industry. A good option is the manufacture of containers of biodegradable materials, such as the so-called biomaterials made of vegetable fibre such as wheat, wood, bamboo or palm leaf pulp. The migration of compounds from food packaging can cause alterations in food safety and acceptability. Therefore, their control through studies of specific migration is definitely important in the food industry. Specific migratio...
Source: Food and Chemical Toxicology - May 28, 2020 Category: Food Science Authors: Asensio E, Montañés L, Nerín C Tags: Food Chem Toxicol Source Type: research

A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals.
Abstract Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic PBTK model implemented in the EuroMix toolbox, MCRA 9 and predict internal kinetics of nine chemicals (three endocrine disrupters, three liver steatosis inducers, and three developmental toxicants), in data-rich and data-poor conditions, when increasingly complex levels of parametrization are applied. At the first stage, only QSAR models were used to determine substance-specific parameters...
Source: Food and Chemical Toxicology - May 27, 2020 Category: Food Science Authors: Tebby C, van der Voet H, de Sousa G, Rorije E, Kumar V, de Boer W, Kruiselbrink JW, Bois FY, Faniband M, Moretto A, Brochot C Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, 3-(p-tert-butylphenyl)-2-methylpropanol (Lysmerol), CAS Registry Number 56107-04-1.
tacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32461159 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 24, 2020 Category: Food Science Authors: Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, R Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, nootkatone, CAS Registry Number 4674-50-4.
riguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32461160 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 24, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, S-isopropyl 3-methylthiobutyrate, CAS Registry Number 34322-06-0.
ultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32461161 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 24, 2020 Category: Food Science Authors: Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Sc Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, p-t-butyl- α-methylhydrocinnamic aldehyde, CAS Registry Number 80-54-6.
RIFM fragrance ingredient safety assessment, p-t-butyl-α-methylhydrocinnamic aldehyde, CAS Registry Number 80-54-6. Food Chem Toxicol. 2020 May 24;:111430 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32461162 [PubMed - as supplied by publisher] (Source: Food...
Source: Food and Chemical Toxicology - May 24, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, S-2-butyl 3-methylbutanethioate, CAS Registry Number 2432-91-9.
ultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32461163 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 24, 2020 Category: Food Science Authors: Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Sc Tags: Food Chem Toxicol Source Type: research

Response surface optimization of phenolic compounds from jabuticaba (Myrciaria cauliflora [Mart.] O.Berg) seeds: Antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments.
Abstract The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-gl...
Source: Food and Chemical Toxicology - May 22, 2020 Category: Food Science Authors: Fidelis M, Vieira do Carmo MA, Azevedo L, Cruz TM, Marques MB, Myoda T, Sant'Ana AS, Furtado MM, Wen M, Zhang L, Rosso ND, Genovese MI, Oh WY, Shahidi F, Pap N, Granato D Tags: Food Chem Toxicol Source Type: research

Prenatal bisphenol-A exposure altered exploratory and anxiety-like behaviour and induced non-monotonic, sex-specific changes in the cortical expression of CYP19A1, BDNF and intracellular signaling proteins in F1 rats.
In this study, pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation day (GD) 9-21. Prenatal BPA exposure, increased anxiety-like behaviour in males and decreased exploratory behaviour in both male and female offspring. Downregulation of both BDNF and CYP19A1 genes were observed in male BPA-exposed offspring, whereas in females, the expression was upregulated. The expression of p-AKT, p-MEK and p-ERK proteins were increased in males, while in females, it decreased. Both the male and the female BPA-exposed offspring exhibited elevated levels of DNMT1 protein. T...
Source: Food and Chemical Toxicology - May 22, 2020 Category: Food Science Authors: Raja GL, Lite C, Subhashree KD, Santosh W, Barathi S Tags: Food Chem Toxicol Source Type: research

The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors.
In conclusion, telmisartan improved memory and cognitive impairment, recovered amyloidogenesis-hyperglycemic axis, astrogliosis, integrity of BBB, memory deficit and oxidonitrosative stress induced in OVX/HFFD/D-Gal rats. PMID: 32450287 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 22, 2020 Category: Food Science Authors: Abo-Youssef AM, Khallaf WA, Khattab MM, Messiha BAS Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, dodecyldimethylamine oxide, CAS Registry Number 1643-20-5.
tacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32445786 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 20, 2020 Category: Food Science Authors: Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, R Tags: Food Chem Toxicol Source Type: research

ROS: Trichothecenes' handy weapon?
Abstract Trichothecenes are a class of toxic secondary metabolites produced by filamentous fungi such as Fusarium, which pose a threat to human and animal health. Among them, T-2 toxin and deoxynivalenol (DON) have attracted the most attention because of their extensive pollution and strong toxicity. Accumulated studies have found that an increase of reactive oxygen species (ROS) during oxidative stress produces a wide range of secondary consequences by modifying cell signaling proteins, such as DNA RNA damage, inflammatory damage, cell cycle arrest, and apoptosis. Although there has been a comprehensive review of...
Source: Food and Chemical Toxicology - May 19, 2020 Category: Food Science Authors: Ren Z, He H, Zuo Z, Xu Z, Wei Z, Deng J Tags: Food Chem Toxicol Source Type: research

Species and geographic variability in truffle aromas.
In this study, we explore the impact that different volatile compounds have on the aroma quality of fresh truffles using gas chromatography-mass spectrometry (GC-MS). Four hundred sixty fresh ascocarps of nine truffle species (Tuber aestivum, Tuber magnatum, Tuber melanosporum, Tuber mesentericum, Tuber brumale, Tuber excavatum, Tuber rufum, Tuber indicum and Tuber macrosporum) harvested in 2018/19 and 2019/2020 from 11 different countries (Slovenia, Croatia, Bosnia in Herzegovina, Macedonia, Italy, Spain, France, United Kingdom, Germany, Poland and China) were collected. Our investigation included the classification of sp...
Source: Food and Chemical Toxicology - May 19, 2020 Category: Food Science Authors: Strojnik L, Grebenc T, Ogrinc N Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, citral, CAS Registry Number 5392-40-5.
riguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32439587 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, hexanoic acid, 6-(acetyloxy)-, ethyl ester, CAS Registry Number 104986-28-9.
riguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32439588 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, p- α,α-trimethylbenzyl alcohol, CAS Registry Number 1197-01-9.
RIFM fragrance ingredient safety assessment, p-α,α-trimethylbenzyl alcohol, CAS Registry Number 1197-01-9. Food Chem Toxicol. 2020 May 18;:111427 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32439589 [PubMed - as supplied by publisher] (Source: Food an...
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

Long noncoding RNA Gm20319, acting as competing endogenous RNA, regulated GNE expression by sponging miR-7240-5p to involve in deoxynivalenol-induced liver damage in vitro.
This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1β in liver, which might involve in liver damage induced by DON. Gm20319 might be a potential research molecular target for DON-induced liver damage. PMID: 32439590 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Liao Y, Peng Z, Wang L, Li D, Yue J, Liu J, Liang C, Liu S, Yan H, Nüssler AK, Rong S, Liu L, Hao L, Yang W Tags: Food Chem Toxicol Source Type: research

Selected food colourants with antiplatelet activity as promising compounds for the prophylaxis and treatment of thrombosis.
Abstract The most common cause of three major cardiovascular disorders, viz. ischemic heart disease (acute coronary syndrome), stroke and venous thromboembolism, is thrombosis. As blood platelets are considered the focal point of haemostasis, they play a key role in thrombosis and other cardiovascular diseases (CVDs). Various studies indicate that certain dietary components, such as phenolic compounds, selected vitamins (A and E) and unsaturated fatty acids, may act as important mediators in the prophylaxis and treatment of CVDs associated with platelet hyperactivation. It is possible that other components, such a...
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Beata Olas, Urbańska K, Bryś M Tags: Food Chem Toxicol Source Type: research

Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1 α pathways in NRK-52E rat kidney cells.
Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells. Food Chem Toxicol. 2020 May 18;:111436 Authors: Liu M, Cheng C, Li X, Zhou S, Hua J, Huang J, Li Y, Yang K, Zhang P, Zhang Y, Tian J Abstract Ochratoxin A (OTA) is a ubiquitous food contaminant and a critical food safety concern due to its nephron toxic effects, which impacts all parts of the world. Luteolin (LUT) had gained increasing interest as a health-promoting food antioxidant component. However, the preventative effect of LUT against OTA induced oxidative stress wa...
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Liu M, Cheng C, Li X, Zhou S, Hua J, Huang J, Li Y, Yang K, Zhang P, Zhang Y, Tian J Tags: Food Chem Toxicol Source Type: research

Cumulative dietary risk assessment overarching different regulatory silos using a margin of exposure approach: A case study with three chemical silos.
Klaveren J Abstract Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic ...
Source: Food and Chemical Toxicology - May 18, 2020 Category: Food Science Authors: Sprong C, Crépet A, Metruccio F, Blaznik U, Anagnostopoulos C, Christodoulou DL, Jensen BH, Kennedy M, González N, Rehurkova I, Ruprich J, Dirk Te Biesebeek J, Vanacker M, Moretto A, van Klaveren J Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, methyl 3-methylthiopropionate, CAS Registry Number 13532-18-8.
ultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32428532 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 16, 2020 Category: Food Science Authors: Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Sc Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, dipropyl disulfide, CAS Registry Number 629-19-6.
tacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32428533 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 16, 2020 Category: Food Science Authors: Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, R Tags: Food Chem Toxicol Source Type: research

Soy flavonoids prevent cognitive deficits induced by intra-gastrointestinal administration of beta-amyloid.
CONCLUSION: Our findings indicate that beta-amyloid can migrate from the gastrointestinal tract to the brain to induce cognitive impairments. Furthermore, chronic soy flavonoids in drinking water have protective actions. PMID: 32417364 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 14, 2020 Category: Food Science Authors: Liu JYH, Sun MYY, Sommerville N, Ngan MP, Ponomarev ED, Lin G, Rudd JA Tags: Food Chem Toxicol Source Type: research

Anti-virulence potential of basil and sage essential oils: Inhibition of biofilm formation, motility and pyocyanin production of Pseudomonas aeruginosa isolates.
Abstract The effects of basil (Ocimum basilicum) and sage (Salvia officinalis) essential oils on selected virulence factors (biofilm formation, mature biofilm resistance, motility, and pyocyanin production) of Pseudomonas aeruginosa clinical isolates were evaluated in the present study for the first time. The two essential oils were chemically characterized by GC and GC-MS analyses. Linalool and (E)-anethole were found to be the main components of the investigated basil oil, while α-thujone and camphor were the major constituents of the studied sage essential oil. The oils inhibited biofilm formation up to 9...
Source: Food and Chemical Toxicology - May 14, 2020 Category: Food Science Authors: Pejčić M, Stojanović-Radić Z, Genčić M, Dimitrijević M, Radulović N Tags: Food Chem Toxicol Source Type: research

Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation.
Abstract Mangiferin (MF) from Mangifera indica has been serendipitously found to ameliorate obesity and is used as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. Nonetheless, the mechanism of MF-induced brown-adipose-tissue activation has not been studied. Therefore, we investigated the effect of MF on thermogenic features during brown-adipocyte differentiation. Treatment with MF improved the expression of a brown-fat signature and of mitochondrial-mass-related genes, thus resulting in UCP1 induction. MF also raised the expression of other thermogenic regulators, including peroxisome proli...
Source: Food and Chemical Toxicology - May 14, 2020 Category: Food Science Authors: Rahman S, Kim YS Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, coumarin, CAS registry number 91-64-5" [Food Chem. Toxicol. 130 (Suppl. 1) (2019) 110522].
Corrigendum to "RIFM fragrance ingredient safety assessment, coumarin, CAS registry number 91-64-5" [Food Chem. Toxicol. 130 (Suppl. 1) (2019) 110522]. Food Chem Toxicol. 2020 May 14;:111406 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32418662 [PubMed - as supplied by publisher] (Source: Food...
Source: Food and Chemical Toxicology - May 14, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Comparison and establishment of appropriate methods to determine EU priority PAHs in charcoal-grilled chicken drumsticks with different treatments and their dietary risk assessments.
Abstract Three major polycyclic aromatic hydrocarbons (PAHs) analytical methods, gas chromatography-mass spectrometer (GC-MS), high performance liquid chromatography-photodiode-array detector (HPLC-PDA) and HPLC-fluorescence detector (FLD) were compared to analyze the European Union (EU) priority PAHs. In addition to the highest sensitivity, HPLC-FLD could be developed to rapidly determine the PAHs. A QuEChERS method was also established to rapidly extract the PAHs from chicken drumsticks. The method detection limits (0.004-0.25 ng/g), method quantification limits (0.01-0.75 ng/g), recoveries (67-114%), and co...
Source: Food and Chemical Toxicology - May 12, 2020 Category: Food Science Authors: Chiang CF, Hsu KC, Cho CY, Tsai TY, Hsu CH, Yang DJ Tags: Food Chem Toxicol Source Type: research

Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro.
Abstract Diets rich in polyphenols are known to reduce cancer among high-risk populations. Haskap (Lonicera caerulea L.) berry has abundant phenolic acids and flavonoids, especially anthocyanins. Tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) present in cigarette smoke is a major lung carcinogenic factor. We analyzed the efficacy of anthocyanin-rich haskap berry extracts in preventing DNA damage induced by 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), a precursor of NKK, in human lung epithelial BEAS-2B cells in vitro. A cocktail of monomeric polyphenols fro...
Source: Food and Chemical Toxicology - May 12, 2020 Category: Food Science Authors: Amararathna M, Hoskin DW, Rupasinghe HPV Tags: Food Chem Toxicol Source Type: research

Dietary exposure to total and inorganic arsenic via rice and rice-based products consumption.
This study was aimed at determining the concentrations of total arsenic (total As) and inorganic arsenic (InAs) in rice and rice products. The dietary exposure and health risks for infant and adult population were also estimated. Brown varieties of rice showed higher As levels than white rice (189 vs 132 μg/kg). Toddlers and infants presented the highest dietary exposure to total As (4.08 and 3.99 μg/day, respectively), but unlike the rest of population groups, the main contributor was organic arsenic. Focusing on the contribution of each food item, rice represents the major contributor to InAs exposure by the ad...
Source: Food and Chemical Toxicology - May 12, 2020 Category: Food Science Authors: González N, Calderón J, Rúbies A, Bosch J, Timoner I, Castell V, Marquès M, Nadal M, Domingo JL Tags: Food Chem Toxicol Source Type: research

Toxicological evaluation of an unextracted Aurantiochytrium limacinum biomass, a novel docosahexaenoic acid rich feed ingredient.
Abstract The purpose of this paper was to evaluate the toxicological potential of a heterotrophically grown unextracted Aurantiochytrium limacinum biomass (AURA) when used as a food additive. The following toxicological assessments were conducted on this novel docosahexaenoic acid rich feed ingredient: Mutagenic activity was tested by means of the Ames' test using five Salmonella typhimurium strains; clastogenic activity was investigated using the micronucleus test in male and female Sprague Dawley rats; genotoxic activity was assessed by means of the in vitro metaphase analysis tests in human lymphocytes; oral to...
Source: Food and Chemical Toxicology - May 12, 2020 Category: Food Science Authors: Dillon GP, Keegan JD, Moran CA Tags: Food Chem Toxicol Source Type: research

Mitochondrial proteomics profile points oxidative phosphorylation as main target for beauvericin and enniatin B mixture.
Abstract Beauvericin (BEA) and enniatin B (EN B) are non-legislated Fusarium mycotoxins usually found in cereal and cereal-based products all around the world. By the proteomic analysis of mitochondria enriched extracts from Jurkat cells exposed for 24 h to three concentrations of BEA:EN B (0.01-0.1-0.5 μM), a number of 1821 proteins (202 mitochondrial) were identified and relatively quantified. 340 proteins (59 mitochondrial) were statistically significant altered in our samples (Anova p-value ≤ 0.05 and fold change (FC) ≥1.5). The protein mitochondrial translational release factor 1 like (MTRF1L...
Source: Food and Chemical Toxicology - May 11, 2020 Category: Food Science Authors: Alonso-Garrido M, Manyes L, Pralea IE, Iuga CA Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110710].
Corrigendum to "RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110710]. Food Chem Toxicol. 2020 May 11;:111410 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32409179 [PubMed - as supplied by publisher] (Sourc...
Source: Food and Chemical Toxicology - May 11, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2 [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110710].
ine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32409180 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 11, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, methoxy dicyclopentadiene carboxaldehyde, CAS Registry Number 86803-90-9" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110826].
Corrigendum to "RIFM fragrance ingredient safety assessment, methoxy dicyclopentadiene carboxaldehyde, CAS Registry Number 86803-90-9" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110826]. Food Chem Toxicol. 2020 May 11;:111413 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32409181 [PubMed - as s...
Source: Food and Chemical Toxicology - May 11, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, CAS Registry Number 107898-54-4" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110715].
Corrigendum to "RIFM fragrance ingredient safety assessment, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, CAS Registry Number 107898-54-4" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110715]. Food Chem Toxicol. 2020 May 10;:111412 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMI...
Source: Food and Chemical Toxicology - May 10, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, 4-(isopropyl)- β-methylcyclohexanethanol, CAS Registry Number 67634-03-1"[Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110713].
Corrigendum to "RIFM fragrance ingredient safety assessment, 4-(isopropyl)-β-methylcyclohexanethanol, CAS Registry Number 67634-03-1"[Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110713]. Food Chem Toxicol. 2020 May 10;:111411 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32402570 [PubMed - a...
Source: Food and Chemical Toxicology - May 10, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, β,β,3-trimethyl benzenepropanol", CAS registry number 103694-68-4 [Food Chem. Toxicol. 130 Suppl. 1 (2019) 110650].
Corrigendum to "RIFM fragrance ingredient safety assessment, β,β,3-trimethyl benzenepropanol", CAS registry number 103694-68-4 [Food Chem. Toxicol. 130 Suppl. 1 (2019) 110650]. Food Chem Toxicol. 2020 May 08;:111408 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32402571 [PubMed - as s...
Source: Food and Chemical Toxicology - May 8, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

Corrigendum to "RIFM fragrance ingredient safety assessment, 4,8-dimethyl-4,9-decadiena", CAS registry number 71077-31-1 [Food Chem. Toxicol. 130, Suppl. 1 (2019) 110648].
Corrigendum to "RIFM fragrance ingredient safety assessment, 4,8-dimethyl-4,9-decadiena", CAS registry number 71077-31-1 [Food Chem. Toxicol. 130, Suppl. 1 (2019) 110648]. Food Chem Toxicol. 2020 May 08;:111407 Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y PMID: 32402572 [PubMed - as supplied by publ...
Source: Food and Chemical Toxicology - May 8, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, Penning TM, Ritacco G, Rodriguez-Ropero F, Ro Tags: Food Chem Toxicol Source Type: research

RIFM fragrance ingredient safety assessment, lauric acid, CAS Registry Number 143-07-7.
riguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S PMID: 32389839 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 7, 2020 Category: Food Science Authors: Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Ro Tags: Food Chem Toxicol Source Type: research

Proteomic analysis using iTRAQ technology reveals the toxic effects of zearalenone on the leydig cells of rats.
This study thus provides a theoretical molecular basis for understanding the toxicological mechanisms by which ZEA affects germ cells. PMID: 32389840 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 7, 2020 Category: Food Science Authors: Wang M, Yang S, Cai J, Yan R, Meng L, Long M, Zhang Y Tags: Food Chem Toxicol Source Type: research

Chemoprotective effect of carotenoids from Lycium barbarum L. on SH-SY5Y neuroblastoma cells treated with beauvericin.
This study aims to determine cytoprotection of lutein (LUT), zeaxanthin (ZEAX) and goji berry extract (GBE) rich in carotenoids against Beauvericin (BEA)-induced cytotoxicity on SH-SY5Y neuroblastoma cells. Both carotenoids and GBE showed cytoprotective effects. Cytoprotection was evaluated by simultaneous combination of the two xanthophylls LUT and ZEAX with BEA, as well as using pre-treatment assays. The highest protective effect occurred in 16%, 24% and 12% respectively for LUT, ZEAX and LUT + ZEAX incubating simultaneously with BEA, while by pre-treatment assay LUT showed a cytoprotection effect over 30% and ...
Source: Food and Chemical Toxicology - May 6, 2020 Category: Food Science Authors: Montesano D, Juan-García A, Mañes J, Juan C Tags: Food Chem Toxicol Source Type: research

Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice.
This study was designed to analyze, in mice fed a high fat and sucrose diet (HFSD), the effects on MetS features of the daily intake of a reverse osmosed, weakly remineralized, water (OW) and of an OW dynamized by a physical processing (ODW), compared to tap water (TW). The HFSD was effective at inducing major features of MetS such as obesity, hepatic steatosis and inflammation, blood dyslipidemia, systemic glucose intolerance and muscle insulin resistance. Compared to TW, OW intake decreased hepatic fibrosis and inflammation, and mitigated hepatic steatosis and dyslipidemia. ODW intake further improved skeletal muscle ins...
Source: Food and Chemical Toxicology - May 5, 2020 Category: Food Science Authors: Lambert K, Gondeau C, Briolotti P, Scheuermann V, Daujat-Chavanieu M, Aimond F Tags: Food Chem Toxicol Source Type: research

Rethinking toxicity testing: Influence of aging on the outcome of long-term toxicity testing and possible remediation.
Abstract Traditionally, toxicity testing is conducted at fixed dose rates (i.e., mg/kg/day) without considering life-changing events, e.g.e.g., stress, sickness, aging- and/or pregnancy-related changes in physical, physiological and biochemical parameters. In humans, life-changing events may cause systemic dose non-proportionality requiring modulation of drug dosage; similar changes occur in animals altering systemic dose during chronic/carcinogenic testing leading to "late-occurring" effects in some studies. For example, propylene monomethyl ether, an industrial chemical, initially induced sedation in r...
Source: Food and Chemical Toxicology - May 4, 2020 Category: Food Science Authors: Saghir SA, Ansari RA, Dorato MA Tags: Food Chem Toxicol Source Type: research

Evaluating missing value imputation methods for food composition databases.
Abstract Missing data are a common problem in most research fields and introduce an element of ambiguity into data analysis. They can arise due to different reasons: mishandling of samples, measurement error, deleted aberrant value or simply lack of analysis. The nutrition domain is no exception to the problem of missing data. This paper addresses the problem of missing data in food composition databases (FCDBs). Missing data in FCDBs results in incomplete FCDBs, which have limited usage, because any dietary assessment can be performed only on a complete dataset. Most often, this problem is resolved by calculating...
Source: Food and Chemical Toxicology - May 4, 2020 Category: Food Science Authors: Ispirova G, Eftimov T, Seljak BK Tags: Food Chem Toxicol Source Type: research

Detoxification of paralytic shellfish poisoning toxins in naturally contaminated mussels, clams and scallops by an industrial procedure.
In this study, we have developed an alternative processing method for bivalves with PSP content above the legal limit, which allows reducing toxicity to acceptable levels. A modification of the PSP detoxifying procedure stablished by Decision 96/77/EC of the European Union in Acanthocardia tuberculatum, was developed and implemented for PSP elimination in other bivalves species. The procedure was applied to 6 batches of mussels, 2 batches of clams and 2 batches of scallops, achieving detoxification rates of around 85%. A viable industrial protocol which allows the transformation of a product at risk into a safe product was...
Source: Food and Chemical Toxicology - May 3, 2020 Category: Food Science Authors: Cabado AG, Lago J, González V, Blanco L, Paz B, Diogène J, Ferreres L, Rambla-Alegre M Tags: Food Chem Toxicol Source Type: research

Natural pseurotins inhibit proliferation and inflammatory responses through the inactivation of STAT signaling pathways in macrophages.
CONCLUSION: Our results advance the current mechanistic understanding of the pseurotin-induced inhibition of proliferation, metabolic respiration and functional responses in macrophages by linking the effect to JAK/STAT signaling pathway. PMID: 32376338 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 3, 2020 Category: Food Science Authors: Vasicek O, Rubanova D, Chytkova B, Kubala L Tags: Food Chem Toxicol Source Type: research

Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology.
Abstract Phenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also been evaluated in the context of many other illnesses in addition to its original epilepsy indication. The narrow therapeutic index of phenytoin and its ubiquitous daily use pose a high risk of poisoning. This review article focuses on the chemistry, pharmacokinetics, and toxicology of phenytoin, with a special focus on its mutagenicity, carcinogenicity, and teratogenicity. The side effects on human health associated with phenytoin use are thoroughly described. In particular, DRESS syndrome and cerebellar atrophy...
Source: Food and Chemical Toxicology - May 3, 2020 Category: Food Science Authors: Patocka J, Wu Q, Nepovimova E, Kuca K Tags: Food Chem Toxicol Source Type: research

(-)-Syringaresinol-4-O- β-D-glucopyranoside from Cortex Albizziae inhibits corticosterone-induced PC12 cell apoptosis and relieves the associated dysfunction.
(-)-Syringaresinol-4-O-β-D-glucopyranoside from Cortex Albizziae inhibits corticosterone-induced PC12 cell apoptosis and relieves the associated dysfunction. Food Chem Toxicol. 2020 Apr 30;:111394 Authors: Yang D, Wu W, Gan G, Wang D, Gong J, Fang K, Lu F Abstract The neuroprotective effects and potential mechanisms of (-)-syringaresinol-4-O-β-D-glucopyranoside (SRG), a natural lignan glycoside extracted from Cortex Albizziae, were investigated using corticosterone (CORT)-induced PC12 cells as an in vitro anxiety model. PC12 cells were treated with 100 μM CORT and 5, 10, or 20 &mu...
Source: Food and Chemical Toxicology - April 30, 2020 Category: Food Science Authors: Yang D, Wu W, Gan G, Wang D, Gong J, Fang K, Lu F Tags: Food Chem Toxicol Source Type: research