Oridonin ameliorates doxorubicin induced-cardiotoxicity via the E2F1/Sirt6/PGC1 α pathway in mice
This study investigates the protective effect of Ori against DIC and elucidates its underlying molecular mechanisms. The results demonstrate that Ori significantly alleviated DIC by improving myocardial structure, reducing the proportion of apoptotic cells, and alleviating the myocardial oxidative damage and mitochondrial dysfunction both in vivo and in vitro. Doxorubicin significantly decreased Sirt6 and PGC1α levels in cardiac tissues, which was reversed by Ori. Furthermore, Sirt6 overexpression significantly improved myocardial structure and reduced the proportion of apoptotic cells by reducing oxidative stress and imp...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Dongsheng Yu Jiye Li Yu Wang Danfeng Guo Chunsheng Zhu Bao Sun Zheng Zhou Source Type: research
Piperlongumine induces apoptosis and autophagy via the PI3K/Akt/mTOR pathway in KB human cervical cancer cells
Food Chem Toxicol. 2023 Sep 19:114051. doi: 10.1016/j.fct.2023.114051. Online ahead of print.ABSTRACTNatural products are continuously being researched to develop safe and effective treatment options for cervical cancer, the fourth most common cancer in women. Piperlongumine (PL), an amide alkaloid mainly present in long pepper, exhibits neuroprotective and anti-cancer properties. However, the specific effect of PL in cervical cancer and the relationship between the anti-cancer pathway and autophagy remain unclear. Therefore, we aimed to investigate PL-induced apoptosis in KB human cervical cancer cells and the relationshi...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Eun-Ji Han Eun-Young Choi Su-Ji Jeon Sang-Woo Lee Jun-Mo Moon Soo-Hyun Jung Bumseok Kim Sung-Dae Cho Jeong-Seok Nam Changsun Choi Jeong-Hwan Che Ji-Youn Jung Source Type: research
In vitro, in vivo, and in silico evaluation of the glucocorticoid receptor antagonist activity of 3,6-dibromocarbazole
Food Chem Toxicol. 2023 Sep 19:114048. doi: 10.1016/j.fct.2023.114048. Online ahead of print.ABSTRACT3,6-Dibromocarbazole is a novel environmental contaminant which is currently detected in several environmental media worldwide. This work aims to investigate the anti-glucocorticoid potency and endocrine disrupting effects of 3,6-dibromocarbazole. In vitro experiments indicated that 3,6-dibromocarbazole possessed glucocorticoid receptor (GR) antagonistic activity and inhibited dexamethasone-induced GR nuclear translocation. 3,6-Dibromocarbazole reduced the expression levels of glucocorticoid responsive genes including gluco...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Haoyang Zou Jia Yu Zhuolin Li Yao Liu Tuoyi Wang Tiezhu Li Chengyu Lv Jie Zhang Source Type: research
Toxicological profiling of a de novo synthesized benzimidazole derivative with potent and selective proapoptotic potentials against breast cancer
This study aimed to investigate the toxicological profile of 1-(6-(1H-benzo[d]imidazole-2-yl)-2-methylpyridin-3-yl) ethanone (BMPE), both in vitro and in vivo. The proapoptotic/necrotic and cell cycle arrest potentials of BMPE were assessed in MCF-7 cell line. The in vivo toxicology was assessed in female Balb/c mice by repeated dosing of 5, 25, and 50 mg/kg for 21 consecutive days, then different biochemical, inflammatory, and oxidative markers were assessed in sera/tissue homogenates of treated animals. The new derivative showed a potent selective cytotoxicity against malignant cell lines with IC50 value 0.2 μM/mL, whil...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Ebtehal K Farrag Wessam M Aziz Sylvia E Shaker Heba Shawky Dalia B Fayed Source Type: research
In response to the Letter to the Editor from Xiao regarding our article, "FEMA GRAS assessment of natural flavor complexes: Asafetida oil, garlic oil and onion oil"
Food Chem Toxicol. 2023 Sep 17:114040. doi: 10.1016/j.fct.2023.114040. Online ahead of print.NO ABSTRACTPMID:37726071 | DOI:10.1016/j.fct.2023.114040 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 19, 2023 Category: Food Science Authors: Jeanne M Davidsen Samuel M Cohen Gerhard Eisenbrand Shoji Fukushima Nigel J Gooderham F Peter Guengerich Stephen S Hecht Ivonne M C M Rietjens Thomas J Rosol Christie L Harman Danarubini Ramanan Sean V Taylor Source Type: research
In response to the Letter to the Editor from Xiao regarding our article, "FEMA GRAS assessment of natural flavor complexes: Asafetida oil, garlic oil and onion oil"
Food Chem Toxicol. 2023 Sep 17:114040. doi: 10.1016/j.fct.2023.114040. Online ahead of print.NO ABSTRACTPMID:37726071 | DOI:10.1016/j.fct.2023.114040 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 19, 2023 Category: Food Science Authors: Jeanne M Davidsen Samuel M Cohen Gerhard Eisenbrand Shoji Fukushima Nigel J Gooderham F Peter Guengerich Stephen S Hecht Ivonne M C M Rietjens Thomas J Rosol Christie L Harman Danarubini Ramanan Sean V Taylor Source Type: research
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Food Chem Toxicol. 2023 Sep 16:114043. doi: 10.1016/j.fct.2023.114043. Online ahead of print.ABSTRACTThe current study was designed to evaluate the protective role of chrysoeriol against polyethylene microplastics (PE-MP) induced testicular damage. Forty eight male rats were distributed into 4 equal groups: vehicle control, PE-MP administrated, PE-MP + chrysoeriol co-administrated and only chrysoeriol supplemented group. The administration of PE-MP significantly reduced the activities of anti-oxidant enzymes, i.e., glutathione peroxidase, catalase, glutathione reductase and superoxide dismutase, whereas the levels of react...
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Muhammad Umar Ijaz Faria Saher Nemra Aslam Ali Hamza Haseeb Anwar Saad Alkahtani Hammad Ahmad Khan Mian Nadeem Riaz Source Type: research
Pterostilbene exerts cytotoxicity on activated hepatic stellate cells by inhibiting excessive proliferation through the crosstalk of Sirt1 and STAT3 pathways
In conclusion, PTE could be potentially beneficial as a natural plant metabolite in preventing and treating hepatic fibrosis.PMID:37722617 | DOI:10.1016/j.fct.2023.114042 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Jiayi Dou Haozhen Cui Zhenyu Cui Meiyan Xuan Chong Gao Zhaoxu Li Lihua Lian Jixing Nan Yanling Wu Source Type: research
Interactions of arsenic exposure, arsenic metabolism with red blood cell folate on the risk of hypertension: NHANES 2007-2016
CONCLUSION: Our results suggested significant interactions between high UTAs and low DMA% with excessive RBC folate on hypertension risk.PMID:37722618 | DOI:10.1016/j.fct.2023.114041 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Yiting Gong Ye Li Xiaoming Zhang Yiming Ma Ying Wu Xueyuan Zhi Source Type: research
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Food Chem Toxicol. 2023 Sep 16:114043. doi: 10.1016/j.fct.2023.114043. Online ahead of print.ABSTRACTThe current study was designed to evaluate the protective role of chrysoeriol against polyethylene microplastics (PE-MP) induced testicular damage. Forty eight male rats were distributed into 4 equal groups: vehicle control, PE-MP administrated, PE-MP + chrysoeriol co-administrated and only chrysoeriol supplemented group. The administration of PE-MP significantly reduced the activities of anti-oxidant enzymes, i.e., glutathione peroxidase, catalase, glutathione reductase and superoxide dismutase, whereas the levels of react...
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Muhammad Umar Ijaz Faria Saher Nemra Aslam Ali Hamza Haseeb Anwar Saad Alkahtani Hammad Ahmad Khan Mian Nadeem Riaz Source Type: research
Pterostilbene exerts cytotoxicity on activated hepatic stellate cells by inhibiting excessive proliferation through the crosstalk of Sirt1 and STAT3 pathways
In conclusion, PTE could be potentially beneficial as a natural plant metabolite in preventing and treating hepatic fibrosis.PMID:37722617 | DOI:10.1016/j.fct.2023.114042 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Jiayi Dou Haozhen Cui Zhenyu Cui Meiyan Xuan Chong Gao Zhaoxu Li Lihua Lian Jixing Nan Yanling Wu Source Type: research
Interactions of arsenic exposure, arsenic metabolism with red blood cell folate on the risk of hypertension: NHANES 2007-2016
CONCLUSION: Our results suggested significant interactions between high UTAs and low DMA% with excessive RBC folate on hypertension risk.PMID:37722618 | DOI:10.1016/j.fct.2023.114041 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Yiting Gong Ye Li Xiaoming Zhang Yiming Ma Ying Wu Xueyuan Zhi Source Type: research
Development of a framework for risk assessment of dietary carcinogens
Food Chem Toxicol. 2023 Sep 14:114022. doi: 10.1016/j.fct.2023.114022. Online ahead of print.ABSTRACTAlthough there are a number of guidance documents and frameworks for evaluation of carcinogenicity, none of the current methods fully reflects the state of the science. Common limitations include the absence of dose-response assessment and not considering the impact of differing exposure patterns (e.g., intermittent, high peaks vs. lower, continuous exposures). To address these issues, we have developed a framework for risk assessment of dietary carcinogens. This framework includes an enhanced approach for weight of evidenc...
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Christopher A Bates Lynne T Haber Martha M Moore Rita Schoeny Andrew Maier Source Type: research
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
Development of a framework for risk assessment of dietary carcinogens
Food Chem Toxicol. 2023 Sep 14:114022. doi: 10.1016/j.fct.2023.114022. Online ahead of print.ABSTRACTAlthough there are a number of guidance documents and frameworks for evaluation of carcinogenicity, none of the current methods fully reflects the state of the science. Common limitations include the absence of dose-response assessment and not considering the impact of differing exposure patterns (e.g., intermittent, high peaks vs. lower, continuous exposures). To address these issues, we have developed a framework for risk assessment of dietary carcinogens. This framework includes an enhanced approach for weight of evidenc...
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Christopher A Bates Lynne T Haber Martha M Moore Rita Schoeny Andrew Maier Source Type: research
