Aqueous extract of pummelo pulp (Citrus maxima) improves the biochemical profile and reduces the inflammation process in Wistar rats with non-alcoholic fatty liver disease
This study investigated the effect of pummelo extract (Citrus maxima) on biochemical, inflammatory, antioxidant and histological changes in NAFLD rats. Forty male Wistar rats divided into four groups were used: (1) control group; (2) fructose associated with high-fat diet - DHF; (3) normal diet + pummelo extract (50 mg/kg); and (4) FHD + pummelo extract. This was administered at dose of 50 mg/kg of the animal's weight, by gavage, for 45 days. Significant improvement in lipid profile, liver and kidney function, inflammation, oxidative stress markers was identified in group 4 compared to group 2. Regarding TNF-α and IL-1β,...
Source: Food and Chemical Toxicology - July 7, 2023 Category: Food Science Authors: Vin ícius Tejada Nunes Itamar Lu ís Gonçalves Patricia Martinez Oliveira Denise Lima Feksa S ílvia Muller de Moura Sarmento G ênifer Erminda Schreiner Cl óvis Klock Charline Casanova Petry Jacqueline da Costa Escobar Piccoli Vanusa Manfredini Cristi Source Type: research
Aqueous extract of pummelo pulp (Citrus maxima) improves the biochemical profile and reduces the inflammation process in Wistar rats with non-alcoholic fatty liver disease
This study investigated the effect of pummelo extract (Citrus maxima) on biochemical, inflammatory, antioxidant and histological changes in NAFLD rats. Forty male Wistar rats divided into four groups were used: (1) control group; (2) fructose associated with high-fat diet - DHF; (3) normal diet + pummelo extract (50 mg/kg); and (4) FHD + pummelo extract. This was administered at dose of 50 mg/kg of the animal's weight, by gavage, for 45 days. Significant improvement in lipid profile, liver and kidney function, inflammation, oxidative stress markers was identified in group 4 compared to group 2. Regarding TNF-α and IL-1β,...
Source: Food and Chemical Toxicology - July 7, 2023 Category: Food Science Authors: Vin ícius Tejada Nunes Itamar Lu ís Gonçalves Patricia Martinez Oliveira Denise Lima Feksa S ílvia Muller de Moura Sarmento G ênifer Erminda Schreiner Cl óvis Klock Charline Casanova Petry Jacqueline da Costa Escobar Piccoli Vanusa Manfredini Cristi Source Type: research
Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9
This study investigates the mechanism by which butyric acid can protect against calcium oxalate (CaOx) nephrolithiasis. To do so, a rat model was used with 0.75% ethylene glycol administration to induce CaOx crystal formation. Histological and von Kossa staining revealed calcium deposits and renal injury, while dihydroethidium fluorescence staining was used to detect reactive oxygen species (ROS) levels. Flow cytometry and TUNEL assays were used to assess apoptosis, respectively. Treatment with sodium butyrate (NaB) was found to partially reverse the oxidative stress, inflammation, and apoptosis associated with CaOx crysta...
Source: Food and Chemical Toxicology - July 6, 2023 Category: Food Science Authors: Zijian Zhou Xuan Zhou Yu Zhang Yuanyuan Yang Lujia Wang Zhong Wu Source Type: research
Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9
This study investigates the mechanism by which butyric acid can protect against calcium oxalate (CaOx) nephrolithiasis. To do so, a rat model was used with 0.75% ethylene glycol administration to induce CaOx crystal formation. Histological and von Kossa staining revealed calcium deposits and renal injury, while dihydroethidium fluorescence staining was used to detect reactive oxygen species (ROS) levels. Flow cytometry and TUNEL assays were used to assess apoptosis, respectively. Treatment with sodium butyrate (NaB) was found to partially reverse the oxidative stress, inflammation, and apoptosis associated with CaOx crysta...
Source: Food and Chemical Toxicology - July 6, 2023 Category: Food Science Authors: Zijian Zhou Xuan Zhou Yu Zhang Yuanyuan Yang Lujia Wang Zhong Wu Source Type: research
Improved family-wise error rate control in multiple equivalence testing
Food Chem Toxicol. 2023 Jul 3;178:113928. doi: 10.1016/j.fct.2023.113928. Online ahead of print.ABSTRACTEquivalence testing is an important component of safety assessments, used for example by the European Food Safety Authority, to allow new food or feed products on the market. The aim of such tests is to demonstrate equivalence of characteristics of test and reference crops. Equivalence tests are typically univariate and applied to each measured analyte (characteristic) separately without multiplicity correction. This increases the probability of making false claims of equivalence (type I errors) when evaluating multiple ...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Gwena ël G R Leday Jesse Hemerik Jasper Engel Hilko van der Voet Source Type: research
Investigation on the potential adverse outcome pathway of the sensitive endpoint for nephrotoxicity induced by gardenia yellow based on an integrated strategy using bioinformatics analysis and in vitro testing validation
Food Chem Toxicol. 2023 Jul 3:113930. doi: 10.1016/j.fct.2023.113930. Online ahead of print.ABSTRACTTo explore the potential the adverse outcome pathway of Gardenia Yellow (GY)-induced sensitive endpoint for nephrotoxicity, an integrated strategy was applied in the present study. Using bioinformatic analysis, based on the constructed Protein-protein interaction networks, Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis on the core target network were performed to illustrate the potential gene targets and signal pathways. Then, the most enriched pathway was validated with Cell c...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Jiang Liang Hong-Xin Wei Ying-Ying Zhou Li-Li Hao Jun-Yu Ning Lei Zhang Source Type: research
Dermal repeated dose toxicity study of the anti-breast cancer drug Formestane cream in Bama minipig
This study evaluated the toxicity of 4-OHA cream on female Bama minipigs in vivo by analyzing hematology, biochemistry, and histopathology. The results showed that there was no significant difference between the cream-treated group and the control normal group for each parameter analyzed, indicating that 4-OHA cream was non-dermal toxic to minipigs. This finding provides a basis for the safe clinical use of the cream.PMID:37406756 | DOI:10.1016/j.fct.2023.113927 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Shiyao Huang Ziming Wu Youyou Chen Han Li Linglin Zou Alexander T Teichmann Yao Luo Lifeng Zhang Lanyang Gao Source Type: research
Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen
CONCLUSION: This is the first systematic evaluation of the catalytic characteristics of 38 CYP2C9 genotypes involved ibuprofen metabolism. Our results provide a corresponding supplement to studies on CYP2C9 gene polymorphisms and kinetic characteristics of different variants. We need to focus on poor metabolizers (PMs) with severely abnormal metabolic functions, because they are more susceptible to drug exposure.PMID:37406757 | DOI:10.1016/j.fct.2023.113926 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Ling-Jing Yuan Xiang-Yu Li Feng Ye Xin-Yue Li Qing-Qing Li Yun-Shan Zhong Shi-Yu Wang Ya-Hui Wang Guo-Xin Hu Jian-Ping Cai Jun-Wei Li Source Type: research
Recent advances in selective allergies to mammalian milk proteins not associated with Cow's Milk Proteins Allergy
Food Chem Toxicol. 2023 Jul 3:113929. doi: 10.1016/j.fct.2023.113929. Online ahead of print.ABSTRACTCow's milk proteins allergy (CMA) is an atypical immune system response to cow's milk and dairy products. It's one of the most common food allergies in children affecting 8% of the total pediatric population pediatric population. This comprehensive review examines recent studies in CMA, especially regarding mammalian milk allergies such as goat's, sheep's, buffalo's, camel's, mare's and donkey's milk allergies in order to increase awareness of these selective allergies and to reduce allergy risks for those who have them. The...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Roua Lajnaf Sawsan Feki Salma Ben Ameur Hamadi Attia Thouraya Kammoun Mohamed Ali Ayadi Hatem Masmoudi Source Type: research
Improved family-wise error rate control in multiple equivalence testing
Food Chem Toxicol. 2023 Jul 3:113928. doi: 10.1016/j.fct.2023.113928. Online ahead of print.ABSTRACTEquivalence testing is an important component of safety assessments, used for example by the European Food Safety Authority, to allow new food or feed products on the market. The aim of such tests is to demonstrate equivalence of characteristics of test and reference crops. Equivalence tests are typically univariate and applied to each measured analyte (characteristic) separately without multiplicity correction. This increases the probability of making false claims of equivalence (type I errors) when evaluating multiple anal...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Gwena ël G R Leday Jesse Hemerik Jasper Engel Hilko van der Voet Source Type: research
Investigation on the potential adverse outcome pathway of the sensitive endpoint for nephrotoxicity induced by gardenia yellow based on an integrated strategy using bioinformatics analysis and in vitro testing validation
Food Chem Toxicol. 2023 Jul 3:113930. doi: 10.1016/j.fct.2023.113930. Online ahead of print.ABSTRACTTo explore the potential the adverse outcome pathway of Gardenia Yellow (GY)-induced sensitive endpoint for nephrotoxicity, an integrated strategy was applied in the present study. Using bioinformatic analysis, based on the constructed Protein-protein interaction networks, Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis on the core target network were performed to illustrate the potential gene targets and signal pathways. Then, the most enriched pathway was validated with Cell c...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Jiang Liang Hong-Xin Wei Ying-Ying Zhou Li-Li Hao Jun-Yu Ning Lei Zhang Source Type: research
Dermal repeated dose toxicity study of the anti-breast cancer drug Formestane cream in Bama minipig
This study evaluated the toxicity of 4-OHA cream on female Bama minipigs in vivo by analyzing hematology, biochemistry, and histopathology. The results showed that there was no significant difference between the cream-treated group and the control normal group for each parameter analyzed, indicating that 4-OHA cream was non-dermal toxic to minipigs. This finding provides a basis for the safe clinical use of the cream.PMID:37406756 | DOI:10.1016/j.fct.2023.113927 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Shiyao Huang Ziming Wu Youyou Chen Han Li Linglin Zou Alexander T Teichmann Yao Luo Lifeng Zhang Lanyang Gao Source Type: research
Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen
CONCLUSION: This is the first systematic evaluation of the catalytic characteristics of 38 CYP2C9 genotypes involved ibuprofen metabolism. Our results provide a corresponding supplement to studies on CYP2C9 gene polymorphisms and kinetic characteristics of different variants. We need to focus on poor metabolizers (PMs) with severely abnormal metabolic functions, because they are more susceptible to drug exposure.PMID:37406757 | DOI:10.1016/j.fct.2023.113926 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Ling-Jing Yuan Xiang-Yu Li Feng Ye Xin-Yue Li Qing-Qing Li Yun-Shan Zhong Shi-Yu Wang Ya-Hui Wang Guo-Xin Hu Jian-Ping Cai Jun-Wei Li Source Type: research
Recent advances in selective allergies to mammalian milk proteins not associated with Cow's Milk Proteins Allergy
Food Chem Toxicol. 2023 Jul 3:113929. doi: 10.1016/j.fct.2023.113929. Online ahead of print.ABSTRACTCow's milk proteins allergy (CMA) is an atypical immune system response to cow's milk and dairy products. It's one of the most common food allergies in children affecting 8% of the total pediatric population pediatric population. This comprehensive review examines recent studies in CMA, especially regarding mammalian milk allergies such as goat's, sheep's, buffalo's, camel's, mare's and donkey's milk allergies in order to increase awareness of these selective allergies and to reduce allergy risks for those who have them. The...
Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Roua Lajnaf Sawsan Feki Salma Ben Ameur Hamadi Attia Thouraya Kammoun Mohamed Ali Ayadi Hatem Masmoudi Source Type: research
Evaluation of the cytotoxicity and genotoxicity potential of synthetic diacetyl food flavoring in silico, in vivo, and in vitro
Food Chem Toxicol. 2023 Jul 1:113923. doi: 10.1016/j.fct.2023.113923. Online ahead of print.ABSTRACTDiacetyl is a common ingredient that creates a buttery flavor in baked goods and other food products. The cytotoxic impact of diacetyl on a normal human liver cell line (THLE2) indicated an IC50 value of 41.29 mg/ml through MTT assay and a cell cycle arrest in the G0/G1 phase relative to the control. Administration of diacetyl at two-time points (acute-chronic) led to a significant increase in DNA damage indicated by the increase in tail length, tail DNA%, and tail moment. The mRNA and protein expression levels of genes in t...
Source: Food and Chemical Toxicology - July 3, 2023 Category: Food Science Authors: Mohamed Salama Dina Mostafa Mohammed Khaled Fahmy Neima K Al-Senosy Naglaa M Ebeed Amr Farouk Source Type: research
