Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect
Food Chem Toxicol. 2023 Jul 17:113949. doi: 10.1016/j.fct.2023.113949. Online ahead of print.ABSTRACTGlucocorticoids have been widely applied to various clinical treatment, however some serious side effects may occur during the treatment. It is widely known that glucocorticoids produce a marked effect through binding to glucocorticoid receptor (GR). As withaferin A can provide multiple health benefits, this work aims to confirm withaferin A as a potential selective GR modulator with anti-inflammatory effect. Fluorescence polarization assay confirmed that withaferin A could steadily bind to GR with an IC50 value of 203.80 ┬...
Source: Food and Chemical Toxicology - July 19, 2023 Category: Food Science Authors: Yuan Liang Qiuyan Jiang Haoyang Zou Jingqi Zhao Jie Zhang Li Ren Source Type: research

Model of neural development by differentiating human induced pluripotent stem cells into neural progenitor cells to study the neurodevelopmental toxicity of lead
In this study, human induced pluripotent stem cells (hiPSCs) were differentiated into neural progenitor cells (NPCs) to investigate the neurotoxic effects of Pb. The hiPSCs were treated with 0, 0.5, 1.0, 2.5, 5.0 and 10.0 ╬╝mol/L Pb for 7 days, whereas embryoid bodies (EBs) and NPCs were treated with 0, 0.1, 0.5, and 1.0 ╬╝mol/L Pb for 7 days. Pb exposure disrupted the cell cycle and caused apoptosis in hiPSCs, EBs, and NPCs. Besides, Pb inhibited the differentiation of NPCs and EBs. Whole exome sequencing revealed 2509, 2413, and 1984 single nucleotide variants (SNVs) caused by Pb in hiPSCs, EBs, and NPCs, respectively. T...
Source: Food and Chemical Toxicology - July 19, 2023 Category: Food Science Authors: Wei Wang Tong Wang Yu Gao Geyu Liang Yuepu Pu Juan Zhang Source Type: research

Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect
Food Chem Toxicol. 2023 Jul 17:113949. doi: 10.1016/j.fct.2023.113949. Online ahead of print.ABSTRACTGlucocorticoids have been widely applied to various clinical treatment, however some serious side effects may occur during the treatment. It is widely known that glucocorticoids produce a marked effect through binding to glucocorticoid receptor (GR). As withaferin A can provide multiple health benefits, this work aims to confirm withaferin A as a potential selective GR modulator with anti-inflammatory effect. Fluorescence polarization assay confirmed that withaferin A could steadily bind to GR with an IC50 value of 203.80 ┬...
Source: Food and Chemical Toxicology - July 19, 2023 Category: Food Science Authors: Yuan Liang Qiuyan Jiang Haoyang Zou Jingqi Zhao Jie Zhang Li Ren Source Type: research

Model of neural development by differentiating human induced pluripotent stem cells into neural progenitor cells to study the neurodevelopmental toxicity of lead
In this study, human induced pluripotent stem cells (hiPSCs) were differentiated into neural progenitor cells (NPCs) to investigate the neurotoxic effects of Pb. The hiPSCs were treated with 0, 0.5, 1.0, 2.5, 5.0 and 10.0 ╬╝mol/L Pb for 7 days, whereas embryoid bodies (EBs) and NPCs were treated with 0, 0.1, 0.5, and 1.0 ╬╝mol/L Pb for 7 days. Pb exposure disrupted the cell cycle and caused apoptosis in hiPSCs, EBs, and NPCs. Besides, Pb inhibited the differentiation of NPCs and EBs. Whole exome sequencing revealed 2509, 2413, and 1984 single nucleotide variants (SNVs) caused by Pb in hiPSCs, EBs, and NPCs, respectively. T...
Source: Food and Chemical Toxicology - July 19, 2023 Category: Food Science Authors: Wei Wang Tong Wang Yu Gao Geyu Liang Yuepu Pu Juan Zhang Source Type: research

In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review
Food Chem Toxicol. 2023 Jul 15:113948. doi: 10.1016/j.fct.2023.113948. Online ahead of print.ABSTRACTNew approach methods (NAMs) have been developed to predict a wide range of toxicities through innovative technologies. Liver injury is one of the most extensively studied endpoints due to its severity and frequency, occurring among populations that consume drugs or dietary supplements. In this review, we focus on recent developments of in silico modeling for liver injury prediction using deep learning and in vitro data based on adverse outcome pathways (AOPs). Despite these models being mainly developed using datasets gener...
Source: Food and Chemical Toxicology - July 17, 2023 Category: Food Science Authors: Hyun Kil Shin Ruili Huang Minjun Chen Source Type: research

In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review
Food Chem Toxicol. 2023 Jul 15:113948. doi: 10.1016/j.fct.2023.113948. Online ahead of print.ABSTRACTNew approach methods (NAMs) have been developed to predict a wide range of toxicities through innovative technologies. Liver injury is one of the most extensively studied endpoints due to its severity and frequency, occurring among populations that consume drugs or dietary supplements. In this review, we focus on recent developments of in silico modeling for liver injury prediction using deep learning and in vitro data based on adverse outcome pathways (AOPs). Despite these models being mainly developed using datasets gener...
Source: Food and Chemical Toxicology - July 17, 2023 Category: Food Science Authors: Hyun Kil Shin Ruili Huang Minjun Chen Source Type: research

Safety concerns regarding impurities in L-Tryptophan associated with eosinophilia myalgia syndrome
Food Chem Toxicol. 2023 Jul 13:113946. doi: 10.1016/j.fct.2023.113946. Online ahead of print.ABSTRACTL-tryptophan is one of the essential amino acids in humans and across the animal kingdom. It has been widely used as a feed additive for domestic animals and is also administered through dietary supplements in humans. Safety concerns have been raised however since a disease known as eosinophilia-myalgia syndrome (EMS) was reported to be related to L-tryptophan supplements. EMS is a rare condition characterized by inflammation in various organ systems including the muscles, skin, and lungs. Through several studies, it has be...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Soo Min Ko Ji-Eun Park In Kyung Heo Yong Uk Shin Yang Hee Kim Woo-Chan Son Source Type: research

Alternatives to animal testing in toxicity testing: Current status and future perspectives in food safety assessments
Food Chem Toxicol. 2023 Jul 13:113944. doi: 10.1016/j.fct.2023.113944. Online ahead of print.ABSTRACTThe development of alternative methods to animal testing has gained great momentum since Russel and Burch introduced the "3Rs" concept of Reduction, Refinement, and Replacement of animals in safety testing in 1959. Several alternatives to animal testing have since been introduced, including but not limited to in vitro and in chemico test systems, in silico models, and computational models (e.g., [quantitative] structural activity relationship models, high-throughput screens, organ-on-chip models, and genomics or bioinformat...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Navya Reddy Barry Lynch Jaspreet Gujral Kavita Karnik Source Type: research

Safety concerns regarding impurities in L-Tryptophan associated with eosinophilia myalgia syndrome
Food Chem Toxicol. 2023 Jul 13:113946. doi: 10.1016/j.fct.2023.113946. Online ahead of print.ABSTRACTL-tryptophan is one of the essential amino acids in humans and across the animal kingdom. It has been widely used as a feed additive for domestic animals and is also administered through dietary supplements in humans. Safety concerns have been raised however since a disease known as eosinophilia-myalgia syndrome (EMS) was reported to be related to L-tryptophan supplements. EMS is a rare condition characterized by inflammation in various organ systems including the muscles, skin, and lungs. Through several studies, it has be...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Soo Min Ko Ji-Eun Park In Kyung Heo Yong Uk Shin Yang Hee Kim Woo-Chan Son Source Type: research

Alternatives to animal testing in toxicity testing: Current status and future perspectives in food safety assessments
Food Chem Toxicol. 2023 Jul 13:113944. doi: 10.1016/j.fct.2023.113944. Online ahead of print.ABSTRACTThe development of alternative methods to animal testing has gained great momentum since Russel and Burch introduced the "3Rs" concept of Reduction, Refinement, and Replacement of animals in safety testing in 1959. Several alternatives to animal testing have since been introduced, including but not limited to in vitro and in chemico test systems, in silico models, and computational models (e.g., [quantitative] structural activity relationship models, high-throughput screens, organ-on-chip models, and genomics or bioinformat...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Navya Reddy Barry Lynch Jaspreet Gujral Kavita Karnik Source Type: research

Safety concerns regarding impurities in L-Tryptophan associated with eosinophilia myalgia syndrome
Food Chem Toxicol. 2023 Jul 13:113946. doi: 10.1016/j.fct.2023.113946. Online ahead of print.ABSTRACTL-tryptophan is one of the essential amino acids in humans and across the animal kingdom. It has been widely used as a feed additive for domestic animals and is also administered through dietary supplements in humans. Safety concerns have been raised however since a disease known as eosinophilia-myalgia syndrome (EMS) was reported to be related to L-tryptophan supplements. EMS is a rare condition characterized by inflammation in various organ systems including the muscles, skin, and lungs. Through several studies, it has be...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Soo Min Ko Ji-Eun Park In Kyung Heo Yong Uk Shin Yang Hee Kim Woo-Chan Son Source Type: research

Alternatives to animal testing in toxicity testing: Current status and future perspectives in food safety assessments
Food Chem Toxicol. 2023 Jul 13:113944. doi: 10.1016/j.fct.2023.113944. Online ahead of print.ABSTRACTThe development of alternative methods to animal testing has gained great momentum since Russel and Burch introduced the "3Rs" concept of Reduction, Refinement, and Replacement of animals in safety testing in 1959. Several alternatives to animal testing have since been introduced, including but not limited to in vitro and in chemico test systems, in silico models, and computational models (e.g., [quantitative] structural activity relationship models, high-throughput screens, organ-on-chip models, and genomics or bioinformat...
Source: Food and Chemical Toxicology - July 15, 2023 Category: Food Science Authors: Navya Reddy Barry Lynch Jaspreet Gujral Kavita Karnik Source Type: research

Perfluorodecanoic acid promotes high-fat diet-triggered adiposity and hepatic lipid accumulation by modulating the NLRP3/caspase-1 pathway in male C57BL/6J mice
In this study, we investigated the effects of PFDA on adiposity development and hepatic lipid accumulation in mice fed with a high-fat diet (HFD). Animals were assigned to two diet treatments (low-fat and high-fat); and PFDA was administered through drinking water for 12 weeks. The contaminant promoted body weight gain and adiposity in HFD-fed mice. Moreover, HFD-fed mice exposed to PFDA had impaired glucose metabolism, inflammation and hepatic lipid accumulation compared to mice fed HFD alone. PFDA activated the expression of hepatic NLRP3 and caspase-1, and induced that of SREBP-1c expression in the liver of HFD-fed mice...
Source: Food and Chemical Toxicology - July 14, 2023 Category: Food Science Authors: Taotao Wang Hong Xu Yu Guo Yuanxin Guo Huanan Guan Dongxu Wang Source Type: research

Comparison of the toxicological potential of two JUUL ENDS products to reference cigarette 3R4F and filtered air in a 90-day nose-only inhalation toxicity study
Food Chem Toxicol. 2023 Jul 12:113917. doi: 10.1016/j.fct.2023.113917. Online ahead of print.ABSTRACTElectronic nicotine delivery systems (ENDS) are generally recognized as less harmful alternatives for those who would otherwise continue to smoke cigarettes. The potential toxicity of aerosols generated from JUUL Device and Virginia Tobacco (VT3) or Menthol (ME3) JUULpods at 3.0% nicotine concentration was assessed in rats exposed at target aerosol concentrations of 1400 ╬╝g/L for up to 6 h/day on a 5 day/week basis for at least 90 days (general accordance with OECD 413). 3R4F reference cigarette smoke (250 ╬╝g/L) and Filte...
Source: Food and Chemical Toxicology - July 14, 2023 Category: Food Science Authors: Rahat Wadhwa Desai Kubilay Demir Nikos Tsolakos Tessa R Moir-Savitz Charles L Gaworski Roxana Weil Michael J Oldham Guy Lalonde Source Type: research

Machine learning for predicting chemical migration from food packaging materials to foods
This study developed a nonlinear machine learning method utilizing chemical properties, material type, food type and temperature to predict chemical migration from package to food. Nine nonlinear algorithms were evaluated for their prediction performance. The ensemble model leveraging multiple algorithms provides state-of-the-art performance that is much better than previous linear regression models. The developed prediction models were subsequently applied to profile the migration potential of FCCs of high toxicity concern. The models are expected to be useful for accelerating the assessment of migration of FCCs from pack...
Source: Food and Chemical Toxicology - July 14, 2023 Category: Food Science Authors: Shan-Shan Wang Pinpin Lin Chia-Chi Wang Ying-Chi Lin Chun-Wei Tung Source Type: research