RIFM fragrance ingredient safety assessment, α,α-dimethylphenethyl butyrate, CAS Registry Number 10094-34-5
Food Chem Toxicol. 2023 Nov 7:114131. doi: 10.1016/j.fct.2023.114131. Online ahead of print.NO ABSTRACTPMID:37944782 | DOI:10.1016/j.fct.2023.114131 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Acute toxicology report of the emerging marine biotoxin Brevetoxin 3 in mice: Food safety implications
Food Chem Toxicol. 2023 Nov 7:114178. doi: 10.1016/j.fct.2023.114178. Online ahead of print.ABSTRACTBrevetoxins (PbTxs) are emerging marine toxins that can lead to Neurotoxic Shellfish Poisoning in humans by the ingestion of contaminated seafood. Recent reports on brevetoxin detection in shellfish in regions where it has not been described before, arise the need of updated guidelines to ensure seafood consumers safety. Our aim was to provide toxicological data for brevetoxin 3 (PbTx3) by assessing oral toxicity in mice and comparing it with intraperitoneal administration. We followed an Up-and-Down procedure administering ...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Celia Costas M Carmen Louzao Sandra Raposo-Garc ía Carmen Vale Almudena Gra ña Cristina Carrera Jos é Manuel Cifuentes Natalia Vilari ño Mercedes R Vieytes Luis M Botana Source Type: research
A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats
Food Chem Toxicol. 2023 Nov 7:114175. doi: 10.1016/j.fct.2023.114175. Online ahead of print.ABSTRACTGanoderma lucidum spore powder is a traditional Chinese medicine with a variety of health benefits. Sporoderm-removed Ganoderma lucidum spores (RGLS) can be more effectively absorbed and utilized by the body. Due to the extensive clinical application and lack of long-term (>30 days) safety evaluation of RGLS, it is necessary to evaluate its repeated dose toxicity during a longer administration period. Here, we conducted a 26-week repeated dose toxicity test of RGLS in Sprague‒Dawley (SD) rats. The male and female rats w...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Lijuan Xia Ruimin Sun Liyan Zhang Jinrong Li Chengda Zhang Qian Yang Lili Zhang Simin Zhang Hanbo Wang Hanying Lyu Wanqiang Lyu Zhenhao Li Lijiang Zhang Source Type: research
Elucidating the mechanism of action of mycotoxins through machine learning-driven QSAR models: Focus on lipid peroxidation
In this study, machine learning models based on quantitative structure-activity relationship (QSAR) were employed to predict the lipid peroxidation activity of mycotoxins. Two different algorithms using Linear Discriminant Analysis (LDA) and Artificial Neural Networks (ANNs) have been trained using a dataset of 70 mycotoxins. The LDA model had an average correct classification rate of 91%, while the ANN model achieved a perfect 100% classification rate. Following an internal validation process, the models were utilized to predict mycotoxins with known lipid peroxidation activity. The machine learning models achieved an 88%...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Maria Galvez-Llompart Riccardo Zanni Lara Manyes Giuseppe Meca Source Type: research
Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3
Food Chem Toxicol. 2023 Nov 7:114156. doi: 10.1016/j.fct.2023.114156. Online ahead of print.ABSTRACTHigh glucose induces Schwann cells death and neurotoxicity. Formononetin was originally found in Astragalus membranaceus and showed anti-tumor and anti-neuroinflammation properties. The aim of this study is to explore the molecular mechanism underlying the neuroprotective effects of formononetin and identify its direct protein target. The effects of formononetin on oxidative stress and mitochondrial dysfunction in Schwann cells induced by high glucose were investigated. High glucose treatment significantly induced oxidative ...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Wen Jiang Ting Hu Chen Ye Man Hu Qingqing Yu Lijuan Sun Jichao Liang Yong Chen Source Type: research