Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system
Food Chem Toxicol. 2024 Jan 23;185:114462. doi: 10.1016/j.fct.2024.114462. Online ahead of print.ABSTRACTZearalenone (ZEN, a widespread fusarium mycotoxin) causes evoked oxidative stress in reproductive system, but little is known about whether this is involved in ferroptosis. Melatonin, a well-known antioxidant, has demonstrated unique anti-antioxidant properties in several studies. Here, this study was aimed to investigate whether ZEN-induced oxidative stress in female pig's reproductive system was involved in ferroptosis, and melatonin was then supplemented to protect against ZEN-induced abnormalities in vitro cell mode...
Source: Food and Chemical Toxicology - January 25, 2024 Category: Food Science Authors: Wei Fu Chao Dai Zifeng Ma Qiao Li Daoliang Lan Changpo Sun Xin Wu Jian Li Shujin Wang Source Type: research
Update to RIFM fragrance ingredient safety assessment, ethyl benzoate, CAS Registry Number 93-89-0
Food Chem Toxicol. 2024 Jan 22;183 Suppl 1:114457. doi: 10.1016/j.fct.2024.114457. Online ahead of print.NO ABSTRACTPMID:38266802 | DOI:10.1016/j.fct.2024.114457 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - January 24, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, 5-methyl-5-phenyl-3-hexanone, CAS Registry Number 4927-36-0
Food Chem Toxicol. 2024 Jan 22;183 Suppl 1:114458. doi: 10.1016/j.fct.2024.114458. Online ahead of print.NO ABSTRACTPMID:38266803 | DOI:10.1016/j.fct.2024.114458 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - January 24, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Protective effects of oral administration of lactic acid bacteria strains against methylmercury-induced intestinal toxicity in a murine model
Food Chem Toxicol. 2024 Jan 20;185:114461. doi: 10.1016/j.fct.2024.114461. Online ahead of print.ABSTRACTThe utilization of lactic acid bacteria has been proposed to mitigate the burden of heavy metal exposure through processes probably involving chelation and reduced metal bioaccessibility. We evaluated the effects of daily intake of two strains of lactobacilli (Lactobacillus intestinalis LE1 or Lactobacillus johnsonii LE2) on intestinal toxicity during methylmercury (MeHg) exposure through drinking water (5 mg/L) for two months in mice. MeHg exposure resulted in inflammation and oxidative stress at the colon, as well as ...
Source: Food and Chemical Toxicology - January 22, 2024 Category: Food Science Authors: Pilar Rodr íguez-Viso Adri án Domene Dinoraz V élez Vicenta Devesa Manuel Z úñiga Vicente Monedero Source Type: research
Development of an in silico evaluation system that quantitatively predicts skin sensitization using OECD Guideline No. 497 ITSv2 defined approach for skin sensitization classification
In this study, we developed a high-performance in silico evaluation system that quantitatively predicts the EC3 values of chemical substances by combining the ITSv2 Defined Approach for hazard identification (ITSv2 HI) with machine learning models. This system uses in chemico/in vitro test data, molecular descriptors, and distance information based on read-across concepts as explanatory variables. The system achieves an R2 value of 0.617 on external-validation data. Substances misclassified in ITSv2 HI are considered to have properties that do not match the correspondence between tests expressing the adverse outcome pathwa...
Source: Food and Chemical Toxicology - January 22, 2024 Category: Food Science Authors: Takaho Asai Kazuhiko Umeshita Michiko Sakurai Shinji Sakane Source Type: research
