Honey flower dermatitis: Contact allergy to ellagic acid in Melianthuscomosus
Food Chem Toxicol. 2023 Jul 21:113956. doi: 10.1016/j.fct.2023.113956. Online ahead of print.ABSTRACTA case study is reported whereby a patient with no prior allergies developed a strong and spreading delayed-type hypersensitivity reaction to Melianthus plants, nectar and synthetic pigment derived from it after frequent handling of these substances. The lesions improved after treatment with topical steroids and allergen avoidance within 1-2 weeks. Subsequent patch testing with the plants, nectar and synthetic ingredients identified ellagic acid (EA) as the sensitizing agent. This is the first proven case of allergic contac...
Source: Food and Chemical Toxicology - July 23, 2023 Category: Food Science Authors: Puneet Arora Evin T Magner Paul L Bigliardi Source Type: research
The bitter side of teas: Pesticide residues and their impact on human health
Food Chem Toxicol. 2023 Jul 21:113955. doi: 10.1016/j.fct.2023.113955. Online ahead of print.ABSTRACTTea (Camellia sinensis) is one of the most widely consumed non-alcoholic beverages globally, known for its rich composition of bioactive compounds that offer various health benefits to humans. However, the cultivation of tea plants often faces challenges due to their high vulnerability to pests and diseases, resulting in the heavy use of pesticides. Consequently, pesticide residues can be transferred to tea leaves, compromising their quality and safety and potentially posing risks to human health, including hormonal and rep...
Source: Food and Chemical Toxicology - July 23, 2023 Category: Food Science Authors: Isabela de Andrade Arruda Fernandes Giselle Maria Maciel D ébora Gonçalves Bortolini Alessandra Cristina Pedro Fernanda Tha ís Vieira Rubio Karina Querne de Carvalho Charles Windson Isidoro Haminiuk Source Type: research
Honey flower dermatitis: Contact allergy to ellagic acid in Melianthuscomosus
Food Chem Toxicol. 2023 Jul 21:113956. doi: 10.1016/j.fct.2023.113956. Online ahead of print.ABSTRACTA case study is reported whereby a patient with no prior allergies developed a strong and spreading delayed-type hypersensitivity reaction to Melianthus plants, nectar and synthetic pigment derived from it after frequent handling of these substances. The lesions improved after treatment with topical steroids and allergen avoidance within 1-2 weeks. Subsequent patch testing with the plants, nectar and synthetic ingredients identified ellagic acid (EA) as the sensitizing agent. This is the first proven case of allergic contac...
Source: Food and Chemical Toxicology - July 23, 2023 Category: Food Science Authors: Puneet Arora Evin T Magner Paul L Bigliardi Source Type: research
The bitter side of teas: Pesticide residues and their impact on human health
Food Chem Toxicol. 2023 Jul 21:113955. doi: 10.1016/j.fct.2023.113955. Online ahead of print.ABSTRACTTea (Camellia sinensis) is one of the most widely consumed non-alcoholic beverages globally, known for its rich composition of bioactive compounds that offer various health benefits to humans. However, the cultivation of tea plants often faces challenges due to their high vulnerability to pests and diseases, resulting in the heavy use of pesticides. Consequently, pesticide residues can be transferred to tea leaves, compromising their quality and safety and potentially posing risks to human health, including hormonal and rep...
Source: Food and Chemical Toxicology - July 23, 2023 Category: Food Science Authors: Isabela de Andrade Arruda Fernandes Giselle Maria Maciel D ébora Gonçalves Bortolini Alessandra Cristina Pedro Fernanda Tha ís Vieira Rubio Karina Querne de Carvalho Charles Windson Isidoro Haminiuk Source Type: research
Black phosphorus quantum dots induced ferroptosis in lung cell via increasing lipid peroxidation and iron accumulation
Food Chem Toxicol. 2023 Jul 20:113952. doi: 10.1016/j.fct.2023.113952. Online ahead of print.ABSTRACTBlack Phosphorus Quantum Dots (BP-QDs) have potential applications in biomedicine. BP-QDs may enter the body through the respiratory tract during grinding and crushing production and processing, causing respiratory toxicity. Ferroptosis is an oxidative, iron-dependent form of cell death. Here, respiratory toxicity of BP-QDs has been validated in mice and human bronchial epithelial cells. After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B ...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Liangding Dou Rong Liu Zhaojizhe Wang Zhi Huang Lei Wang Mo Lin Xin Hou Jinwen Zhang Tantan Cheng Qi He Dai Wang Dongbei Guo Ran An Lifang Wei Youliang Yao Yongxing Zhang Source Type: research
Mitophagy contributes to zinc-induced ferroptosis in porcine testis cells
In this study, a total of 60 male weaned pigs were randomly divided into three groups and the content of Zn were 75 mg/kg (control), 750 mg/kg (Zn-I), 1500 mg/kg (Zn-II). Meanwhile, testicular cells were treated with ZnSO4 (0, 50 and 100 μM), and in combination of ZnSO4 (100 μM) and ferrostation-1, ML-210, or 3-methyladenine for 24 h. Our results verified that Zn could cause ferroptosis and lipid peroxidation, which were characterized by down-regulating level of SLC7A11, GPX4, and ferritin, and up-regulating levels of MDA, CD71, TF, and HMGB1 by Western blot, immunohistochemistry, immunofluorescence, peroxidase assay, et...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Quanwei Li Qingwen Yang Pan Guo Yuanhong Feng Shaofeng Wang Jianying Guo Zhaoxin Tang Wenlan Yu Jianzhao Liao Source Type: research
Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway
In this study, arsenic exposure resulted in mitochondrial PGAM5 activation and subsequent activation of apoptosis and AMPK-mTOR dependent autophagy. Intervention by autophagy activator Rapamycin or inhibitor 3-MA, both targeting at mTOR, accordingly induced activation or inhibition of apoptosis. Intervention by MK-3903 or dorsomorphin, activator or inhibitor of AMPK, received similar results. Our findings suggested that arsenic-induced PGAM5 activation played a role in AMPK-mTOR dependent autophagy and arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway.PMID:37481228 | DOI:1...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Yao Chen Xudan Liu Qianhui Zhang Huanhuan Wang Ruo Zhang Yanhong Ge Huning Liang Wanying Li Juanjun Fan Huimin Liu Zhengyang Lv Wenting Dou Yi Wang Xin Li Source Type: research
The 50th percentile of the general population single eating occasion intake of food is optimal for the calculation of action levels for precautionary allergen labelling
Food Chem Toxicol. 2023 Jul 20:113953. doi: 10.1016/j.fct.2023.113953. Online ahead of print.ABSTRACTLack of guidance regarding selection of food intake values for allergen risk assessment can lead to different outcomes for similar levels of allergens in food products. Several food consumption survey databases (United States, North-West Europe, and Netherlands) were analyzed to identify optimal food intake percentiles using a sensitivity analysis. Deterministic risk assessment scenarios using the 50th percentile up to the maximum intake per food group were compared with probabilistic risk assessment outcomes. The optimal i...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: W Marty Blom Joost Westerhout Geert F Houben Source Type: research
Black phosphorus quantum dots induced ferroptosis in lung cell via increasing lipid peroxidation and iron accumulation
Food Chem Toxicol. 2023 Jul 20:113952. doi: 10.1016/j.fct.2023.113952. Online ahead of print.ABSTRACTBlack Phosphorus Quantum Dots (BP-QDs) have potential applications in biomedicine. BP-QDs may enter the body through the respiratory tract during grinding and crushing production and processing, causing respiratory toxicity. Ferroptosis is an oxidative, iron-dependent form of cell death. Here, respiratory toxicity of BP-QDs has been validated in mice and human bronchial epithelial cells. After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B ...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Liangding Dou Rong Liu Zhaojizhe Wang Zhi Huang Lei Wang Mo Lin Xin Hou Jinwen Zhang Tantan Cheng Qi He Dai Wang Dongbei Guo Ran An Lifang Wei Youliang Yao Yongxing Zhang Source Type: research
Mitophagy contributes to zinc-induced ferroptosis in porcine testis cells
In this study, a total of 60 male weaned pigs were randomly divided into three groups and the content of Zn were 75 mg/kg (control), 750 mg/kg (Zn-I), 1500 mg/kg (Zn-II). Meanwhile, testicular cells were treated with ZnSO4 (0, 50 and 100 μM), and in combination of ZnSO4 (100 μM) and ferrostation-1, ML-210, or 3-methyladenine for 24 h. Our results verified that Zn could cause ferroptosis and lipid peroxidation, which were characterized by down-regulating level of SLC7A11, GPX4, and ferritin, and up-regulating levels of MDA, CD71, TF, and HMGB1 by Western blot, immunohistochemistry, immunofluorescence, peroxidase assay, et...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Quanwei Li Qingwen Yang Pan Guo Yuanhong Feng Shaofeng Wang Jianying Guo Zhaoxin Tang Wenlan Yu Jianzhao Liao Source Type: research
Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway
In this study, arsenic exposure resulted in mitochondrial PGAM5 activation and subsequent activation of apoptosis and AMPK-mTOR dependent autophagy. Intervention by autophagy activator Rapamycin or inhibitor 3-MA, both targeting at mTOR, accordingly induced activation or inhibition of apoptosis. Intervention by MK-3903 or dorsomorphin, activator or inhibitor of AMPK, received similar results. Our findings suggested that arsenic-induced PGAM5 activation played a role in AMPK-mTOR dependent autophagy and arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway.PMID:37481228 | DOI:1...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: Yao Chen Xudan Liu Qianhui Zhang Huanhuan Wang Ruo Zhang Yanhong Ge Huning Liang Wanying Li Juanjun Fan Huimin Liu Zhengyang Lv Wenting Dou Yi Wang Xin Li Source Type: research
The 50th percentile of the general population single eating occasion intake of food is optimal for the calculation of action levels for precautionary allergen labelling
Food Chem Toxicol. 2023 Jul 20:113953. doi: 10.1016/j.fct.2023.113953. Online ahead of print.ABSTRACTLack of guidance regarding selection of food intake values for allergen risk assessment can lead to different outcomes for similar levels of allergens in food products. Several food consumption survey databases (United States, North-West Europe, and Netherlands) were analyzed to identify optimal food intake percentiles using a sensitivity analysis. Deterministic risk assessment scenarios using the 50th percentile up to the maximum intake per food group were compared with probabilistic risk assessment outcomes. The optimal i...
Source: Food and Chemical Toxicology - July 22, 2023 Category: Food Science Authors: W Marty Blom Joost Westerhout Geert F Houben Source Type: research
Exploring the binding mechanism and adverse toxic effects of degradation metabolites of pyrethroid insecticides to human serum albumin: Multi-spectroscopy, calorimetric and molecular docking approaches
In this study, the binding interaction mechanisms between human serum albumin (HSA) and the main degradation metabolites of PIs, 3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), were studied by theoretical simulation and experimental verification. Steady state fluorescence spectra showed that the fluorescence quenching mechanism was static. According to the binding constant, 4-F-3-PBA (1.53 × 105 L mol-1) was bound more strongly to HSA than 3-PBA (1.42 × 105 L mol-1) in subdomain ⅡA (site I). It was found by isothermal titration calorimetry that the metabolites and HSA spontaneously combine...
Source: Food and Chemical Toxicology - July 21, 2023 Category: Food Science Authors: Yiwen Cui Yingying Sun Hang Yu Yahui Guo Weirong Yao Yunfei Xie Fangwei Yang Source Type: research
Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches
This study aims to explore the male reproductive toxicity of Benzo[b]fluoranthene (BbF) and related mechanisms. The results of computational toxicology analysis indicated male reproductive toxicity of BbF was related to apoptosis of Leydig cells and that Akt/p53 pathway might play a key role. In experiments, BbF induced testosterone decline, decreased concentration and motility of sperm and aggravated testicular pathological injury in mice. Besides, BbF led to apoptosis in Leydig cells, and decreased expressions of p-Akt and Bcl2, while improving the expressions of p53, Bax and Cleaved Caspase-3 in vivo and in vitro. Furth...
Source: Food and Chemical Toxicology - July 20, 2023 Category: Food Science Authors: Chao-Feng Shi Fei Han Xiao Jiang Zhonghao Zhang Yingqing Li Jiankang Wang Shengqi Sun Jin-Yi Liu Jia Cao Source Type: research
Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches
This study aims to explore the male reproductive toxicity of Benzo[b]fluoranthene (BbF) and related mechanisms. The results of computational toxicology analysis indicated male reproductive toxicity of BbF was related to apoptosis of Leydig cells and that Akt/p53 pathway might play a key role. In experiments, BbF induced testosterone decline, decreased concentration and motility of sperm and aggravated testicular pathological injury in mice. Besides, BbF led to apoptosis in Leydig cells, and decreased expressions of p-Akt and Bcl2, while improving the expressions of p53, Bax and Cleaved Caspase-3 in vivo and in vitro. Furth...
Source: Food and Chemical Toxicology - July 20, 2023 Category: Food Science Authors: Chao-Feng Shi Fei Han Xiao Jiang Zhonghao Zhang Yingqing Li Jiankang Wang Shengqi Sun Jin-Yi Liu Jia Cao Source Type: research
