Arsenic aggravates the progression of diabetic nephropathy through miRNA-mRNA-autophagy axis
In this study, an arsenic-exposed (10 mg/L and 25 mg/L) DN mouse model was established through drinking water for 14 weeks. The results showed that 25 mg/L arsenic exposure increased the renal fibrosis in DN mice significantly, and urinary mAlb level increased with the increasing of arsenic exposure level. RNA sequencing showed that autophagy-related pathways were significantly activated under the exposure dose of 25 mg/L, and levels of Beclin1 and p-ATG16L1/ATG16L1 were significantly higher in the 25 mg/L arsenic group compared to the control group. Silico analysis predicted the microRNAs that could regulate the hub genes...
Source: Food and Chemical Toxicology - April 5, 2024 Category: Food Science Authors: Xiaodan Zhang Sira Jackson Jianhao Liu Jinyu Li Zhihan Yang Dianjun Sun Wei Zhang Source Type: research
Arsenic aggravates the progression of diabetic nephropathy through miRNA-mRNA-autophagy axis
In this study, an arsenic-exposed (10 mg/L and 25 mg/L) DN mouse model was established through drinking water for 14 weeks. The results showed that 25 mg/L arsenic exposure increased the renal fibrosis in DN mice significantly, and urinary mAlb level increased with the increasing of arsenic exposure level. RNA sequencing showed that autophagy-related pathways were significantly activated under the exposure dose of 25 mg/L, and levels of Beclin1 and p-ATG16L1/ATG16L1 were significantly higher in the 25 mg/L arsenic group compared to the control group. Silico analysis predicted the microRNAs that could regulate the hub genes...
Source: Food and Chemical Toxicology - April 5, 2024 Category: Food Science Authors: Xiaodan Zhang Sira Jackson Jianhao Liu Jinyu Li Zhihan Yang Dianjun Sun Wei Zhang Source Type: research
Toosendanin induces hepatotoxicity via disrupting LXR α/Lipin1/SREBP1 mediated lipid metabolism
In conclusion, TSN caused lipid metabolism disorder in liver via inhibiting LXRα/Lipin1/SREBP1 signaling pathway.PMID:38570025 | DOI:10.1016/j.fct.2024.114631 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 3, 2024 Category: Food Science Authors: Sixin Chen Jiajie Ni Li Luo Jinxian Lin Hongjie Peng Feihai Shen Zhiying Huang Source Type: research
Toosendanin induces hepatotoxicity via disrupting LXR α/Lipin1/SREBP1 mediated lipid metabolism
In conclusion, TSN caused lipid metabolism disorder in liver via inhibiting LXRα/Lipin1/SREBP1 signaling pathway.PMID:38570025 | DOI:10.1016/j.fct.2024.114631 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 3, 2024 Category: Food Science Authors: Sixin Chen Jiajie Ni Li Luo Jinxian Lin Hongjie Peng Feihai Shen Zhiying Huang Source Type: research
Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation
In conclusion, CPF inhibited the expansion of cumulus and caused oxidative stress and apoptosis as well as disturbed the function of gap junctions (GJs) and TZPs, which eventually resulted in the failure of oocyte maturation.PMID:38565334 | DOI:10.1016/j.fct.2024.114629 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 2, 2024 Category: Food Science Authors: Yajie Chu Qiao Li Yijing He Heran Li Qijia Wang Shurui Li Jianuo Wang Weihan Wang Shiqiang Ju Source Type: research
Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation
In conclusion, CPF inhibited the expansion of cumulus and caused oxidative stress and apoptosis as well as disturbed the function of gap junctions (GJs) and TZPs, which eventually resulted in the failure of oocyte maturation.PMID:38565334 | DOI:10.1016/j.fct.2024.114629 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 2, 2024 Category: Food Science Authors: Yajie Chu Qiao Li Yijing He Heran Li Qijia Wang Shurui Li Jianuo Wang Weihan Wang Shiqiang Ju Source Type: research
Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
In vivo Tebuconazole administration impairs heart electrical function and facilitates the occurrence of dobutamine-induced arrhythmias: Involvement of reactive oxygen species
In conclusion, TEB at the no observed adverse effect level (NOAEL) dose adversely affects heart electrical function, increases arrhythmic susceptibility, partially through ROS overproduction, and this phenotype is reversible by scavenging ROS with NAC.PMID:38556154 | DOI:10.1016/j.fct.2024.114596 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Jorge Lucas Teixeira-Fonseca Diego Santos Souza Michael Ramon de Lima Concei ção Leisiane Pereira Marques Aim ée Obolari Durço Polyana Leal da Silva Julliane V Joviano-Santos Artur Santos-Miranda Danilo Roman-Campos Source Type: research
Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice
Food Chem Toxicol. 2024 Mar 29:114624. doi: 10.1016/j.fct.2024.114624. Online ahead of print.ABSTRACTDiclofenac, a widely used non-steroidal anti-inflammatory drug, can cause liver damage via its metabolic activation by hepatic CYP450s and UGT2B7. Fasting can affect drug-induced liver injury by modulating the hepatic metabolism, but its influence on diclofenac hepatotoxicity is unknown. Thus, we investigated diclofenac-induced liver damage after fasting in mice, and the cellular events were examined. Male ICR mice fasted for 16 h showed the elevation of CYP3A11, but the decreases of UGT2B7, glutathione (GSH), and GSH S-tra...
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Doyoung Kwon Hyeji Seo Sou Hyun Kim Ki Wung Chung Jaewon Lee Young-Suk Jung Source Type: research
Update to RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2
Food Chem Toxicol. 2024 Mar 29:114551. doi: 10.1016/j.fct.2024.114551. Online ahead of print.NO ABSTRACTPMID:38556156 | DOI:10.1016/j.fct.2024.114551 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects
Food Chem Toxicol. 2024 Mar 29:114626. doi: 10.1016/j.fct.2024.114626. Online ahead of print.ABSTRACTRutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250-500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical literature of its multi-system chemo-preventive properties. The present paper provides the first assessment of rutin-induced hormetic concentration/dose responses, their quantitative features and mechanistic basis, along with their biological, biomedical, clinical, and publi...
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Edward J Calabrese Peter Pressman A Wallace Hayes Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese Source Type: research
Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes
This study employed a comprehensive approach to validate the hepatoprotective potential of phytoconstituents from Cichorium intybus leaves. In vitro, in vivo and in silico techniques were used to confirm the protective effects on liver enzymes. In vitro antioxidant assessment revealed the highest potential in the hydroethanolic leaf extract compared to aqueous and methanolic extracts. The study further investigated the ameliorative efficacy of the hydro-ethanolic extract (HECL) in male Wistar rats exposed to lead (50 mg/kg b wt.) and nickel (4.0 mg/kg b wt.) individually and in combination for 90 days. HECL at 250 mg/kg b ...
Source: Food and Chemical Toxicology - March 30, 2024 Category: Food Science Authors: Abhishek Pathak Satya Pal Singh Apoorv Tiwari Source Type: research
Attenuated neuronal differentiation caused by acrylamide is not related to oxidative stress in differentiated human neuroblastoma SH-SY5Y cells
Food Chem Toxicol. 2024 Mar 28:114623. doi: 10.1016/j.fct.2024.114623. Online ahead of print.ABSTRACTAcrylamide (ACR) is a known neurotoxicant and developmental neurotoxicant. As a soft electrophile, ACR reacts with thiol groups in cysteine. One hypothesis of ACR induced neurotoxicity and developmental neurotoxicity (DNT) is conjugation with reduced glutathione (GSH) leading to GSH depletion, increased reactive oxygen species (ROS) production and further oxidative stress and cellular damage. In this regard, we have investigated the effect of ACR on neuronal differentiation, glutathione levels and ROS production in the huma...
Source: Food and Chemical Toxicology - March 30, 2024 Category: Food Science Authors: Ylva Johansson Mathilda Andreassen Muriel Hartsch Stella Wagner Anna Forsby Source Type: research
Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes
This study employed a comprehensive approach to validate the hepatoprotective potential of phytoconstituents from Cichorium intybus leaves. In vitro, in vivo and in silico techniques were used to confirm the protective effects on liver enzymes. In vitro antioxidant assessment revealed the highest potential in the hydroethanolic leaf extract compared to aqueous and methanolic extracts. The study further investigated the ameliorative efficacy of the hydro-ethanolic extract (HECL) in male Wistar rats exposed to lead (50 mg/kg b wt.) and nickel (4.0 mg/kg b wt.) individually and in combination for 90 days. HECL at 250 mg/kg b ...
Source: Food and Chemical Toxicology - March 30, 2024 Category: Food Science Authors: Abhishek Pathak Satya Pal Singh Apoorv Tiwari Source Type: research
