Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption
Food Chem Toxicol. 2023 Sep 2:114024. doi: 10.1016/j.fct.2023.114024. Online ahead of print.ABSTRACTChlordane is an organochlorine pesticide (OCP) that is environmentally persistent. Although exposures to OCPs including chlordane have been associated with elevated liver enzymes, current knowledge on OCPs' contribution to toxicant-associated steatotic liver disease (TASLD) and underlying sex-specific metabolic/endocrine disruption are still widely limited. Therefore, the objective of this study was to investigate the sex-dependent effects of chlordane in the context of TASLD. Age-matched male and female C57BL/6 mice were ex...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Jianzhu Luo Walter H Watson Tyler C Gripshover Zayna Qaissi Banrida Wahlang Source Type: research
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity
Food Chem Toxicol. 2023 Sep 2;180:114012. doi: 10.1016/j.fct.2023.114012. Online ahead of print.ABSTRACTIn order to investigate the amelioration of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on bisphenol A (BPA)-induced nephrotoxicity, the murine nephrotoxicity model was established by intragastric administration of BPA (5 mg/kg/B.W.) for 6 weeks. The biochemical indices, hematoxylin-eosin (H&E) staining, kidney metabolomics, and related protein expression levels of SIRT1-AMPK pathway were then determined. Our results indicated that DHA-PS (100 mg/kg/B.W.) ameliorated the BPA-induced nephrotoxicity after...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Qiuyan Pu Fei Yang Rui Zhao Su Jiang Yunping Tang Tao Han Source Type: research
Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption
Food Chem Toxicol. 2023 Sep 2:114024. doi: 10.1016/j.fct.2023.114024. Online ahead of print.ABSTRACTChlordane is an organochlorine pesticide (OCP) that is environmentally persistent. Although exposures to OCPs including chlordane have been associated with elevated liver enzymes, current knowledge on OCPs' contribution to toxicant-associated steatotic liver disease (TASLD) and underlying sex-specific metabolic/endocrine disruption are still widely limited. Therefore, the objective of this study was to investigate the sex-dependent effects of chlordane in the context of TASLD. Age-matched male and female C57BL/6 mice were ex...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Jianzhu Luo Walter H Watson Tyler C Gripshover Zayna Qaissi Banrida Wahlang Source Type: research
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on Bisphenol A-induced murine nephrotoxicity
Food Chem Toxicol. 2023 Sep 2:114012. doi: 10.1016/j.fct.2023.114012. Online ahead of print.ABSTRACTIn order to investigate the amelioration of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on bisphenol A (BPA)-induced nephrotoxicity, the murine nephrotoxicity model was established by intragastric administration of BPA (5 mg/kg/B.W.) for 6 weeks. The biochemical indices, hematoxylin-eosin (H&E) staining, kidney metabolomics, and related protein expression levels of SIRT1-AMPK pathway were then determined. Our results indicated that DHA-PS (100 mg/kg/B.W.) ameliorated the BPA-induced nephrotoxicity after 6 w...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Qiuyan Pu Fei Yang Rui Zhao Su Jiang Yunping Tang Tao Han Source Type: research
Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption
Food Chem Toxicol. 2023 Sep 2:114024. doi: 10.1016/j.fct.2023.114024. Online ahead of print.ABSTRACTChlordane is an organochlorine pesticide (OCP) that is environmentally persistent. Although exposures to OCPs including chlordane have been associated with elevated liver enzymes, current knowledge on OCPs' contribution to toxicant-associated steatotic liver disease (TASLD) and underlying sex-specific metabolic/endocrine disruption are still widely limited. Therefore, the objective of this study was to investigate the sex-dependent effects of chlordane in the context of TASLD. Age-matched male and female C57BL/6 mice were ex...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Jianzhu Luo Walter H Watson Tyler C Gripshover Zayna Qaissi Banrida Wahlang Source Type: research
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on Bisphenol A-induced murine nephrotoxicity
Food Chem Toxicol. 2023 Sep 2:114012. doi: 10.1016/j.fct.2023.114012. Online ahead of print.ABSTRACTIn order to investigate the amelioration of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on bisphenol A (BPA)-induced nephrotoxicity, the murine nephrotoxicity model was established by intragastric administration of BPA (5 mg/kg/B.W.) for 6 weeks. The biochemical indices, hematoxylin-eosin (H&E) staining, kidney metabolomics, and related protein expression levels of SIRT1-AMPK pathway were then determined. Our results indicated that DHA-PS (100 mg/kg/B.W.) ameliorated the BPA-induced nephrotoxicity after 6 w...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Qiuyan Pu Fei Yang Rui Zhao Su Jiang Yunping Tang Tao Han Source Type: research
Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption
Food Chem Toxicol. 2023 Sep 2:114024. doi: 10.1016/j.fct.2023.114024. Online ahead of print.ABSTRACTChlordane is an organochlorine pesticide (OCP) that is environmentally persistent. Although exposures to OCPs including chlordane have been associated with elevated liver enzymes, current knowledge on OCPs' contribution to toxicant-associated steatotic liver disease (TASLD) and underlying sex-specific metabolic/endocrine disruption are still widely limited. Therefore, the objective of this study was to investigate the sex-dependent effects of chlordane in the context of TASLD. Age-matched male and female C57BL/6 mice were ex...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Jianzhu Luo Walter H Watson Tyler C Gripshover Zayna Qaissi Banrida Wahlang Source Type: research
Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen
This study explored the role of metabolic activation by cytochrome P450 (CYP) enzymes in psoralen- and isopsoralen-induced cytotoxicity and its potential mechanisms. Inhibitors of CYP1A2, 2C9, 2C19, 2D6, 2E1, and 3A4 were used to screen specific CYP enzymes responsible for the metabolic activation of psoralen and isopsoralen in mouse primary hepatocytes, which was verified using the corresponding transfected cell lines. Network toxicology and transcriptome analyses were performed to explore the mechanisms underlying toxicity. Psoralen and isopsoralen decreased the viability of mouse primary hepatocytes, whereas the inhibit...
Source: Food and Chemical Toxicology - September 3, 2023 Category: Food Science Authors: Shuaishuai Chen Weiyu Guo Huan Liu Jiang Zheng Dingyan Lu Jia Sun Chun Li Chunhua Liu Yonglin Wang Yong Huang Wen Liu Yongjun Li Ting Liu Source Type: research
Exposure to bromoxynil octanoate herbicide induces oxidative stress, inflammation, and apoptosis in testicular tissue via modulating NF- кB pathway
In conclusion BO-induced testicular damage by altering oxidation, inflammation, and apoptosis.PMID:37660944 | DOI:10.1016/j.fct.2023.114008 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 3, 2023 Category: Food Science Authors: Maysa M F El-Nagar Alaa E Elsisi Source Type: research
Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen
This study explored the role of metabolic activation by cytochrome P450 (CYP) enzymes in psoralen- and isopsoralen-induced cytotoxicity and its potential mechanisms. Inhibitors of CYP1A2, 2C9, 2C19, 2D6, 2E1, and 3A4 were used to screen specific CYP enzymes responsible for the metabolic activation of psoralen and isopsoralen in mouse primary hepatocytes, which was verified using the corresponding transfected cell lines. Network toxicology and transcriptome analyses were performed to explore the mechanisms underlying toxicity. Psoralen and isopsoralen decreased the viability of mouse primary hepatocytes, whereas the inhibit...
Source: Food and Chemical Toxicology - September 3, 2023 Category: Food Science Authors: Shuaishuai Chen Weiyu Guo Huan Liu Jiang Zheng Dingyan Lu Jia Sun Chun Li Chunhua Liu Yonglin Wang Yong Huang Wen Liu Yongjun Li Ting Liu Source Type: research
Exposure to bromoxynil octanoate herbicide induces oxidative stress, inflammation, and apoptosis in testicular tissue via modulating NF- кB pathway
In conclusion BO-induced testicular damage by altering oxidation, inflammation, and apoptosis.PMID:37660944 | DOI:10.1016/j.fct.2023.114008 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - September 3, 2023 Category: Food Science Authors: Maysa M F El-Nagar Alaa E Elsisi Source Type: research
Exposure to pesticide residues in honey and its potential cancer risk assessment
Food Chem Toxicol. 2023 Aug 31:114014. doi: 10.1016/j.fct.2023.114014. Online ahead of print.ABSTRACTHoney is the most recognized natural food by-product of flower nectar and the upper aero-digestive tract of the honeybees. Significance of honey for its medicinal importance are well-documented in the world's oldest medical literatures. However, the current urbanization, environmental contaminations and changes in agricultural, as well as apiculture practices has led to various types of contaminations in honey. Among all, pesticide contamination has become one of the major issues worldwide. This review focuses on the recent...
Source: Food and Chemical Toxicology - September 2, 2023 Category: Food Science Authors: Syed Amir Ashraf Danish Mahmood Abd Elmoneim O Elkhalifa Arif Jamal Siddiqui Mohammad Idreesh Khan Fauzia Ashfaq Mitesh Patel Mejdi Snoussi Marek Kieliszek Mohd Adnan Source Type: research
Dietary N < sup > ε < /sup > -(carboxymethyl)lysine is a trigger of non-alcoholic fatty liver disease under high-fat consumption
In this study, we focus the promoting effect of Nε-carboxymethyl-lysine (CML), one of the most dietary AGEs, on non-alcoholic fatty liver disease (NAFLD) and evaluated NAFLD-related biomarkers. Oxidative stress and hepatic steatosis were assessed in oleic acid (OA)-induced HepG2 cells. Using OA-induced HepG2 cells, we show that CML results in oxidative stress and steatosis and drives major changes in hepatic lipid metabolism. Administration of CML exacerbated NAFLD-related symptoms by increasing body and liver weight gain, serum alanine aminotransferase and lipid levels, and insulin resistance in mild high-fat diet-induce...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Hye-Bin Lee Ju Hyeong Choi Donghwan Kim Kwang-Won Lee Sang Keun Ha Sang-Hoon Lee Ho-Young Park Source Type: research
Fermentation patterns of prebiotics fructooligosaccharides-SCFA esters inoculated with fecal microbiota from ulcerative colitis patients
In this study, esters formed by binding of well-known prebiotics, fructooligosaccharides (FOS), with short chain fatty acids (SCFAs) via both enzymatic and chemical methods were evaluated for their impact on the gut microbiota of UC patients. An in vitro human colonic fermentation model was employed to monitor changes in total carbohydrates and SCFAs production during the fermentation of these esters by microbiota from patients with active and remission UC. The results showed that pronounced abundance of [Ruminococcus]_gnavus_group, Escherichia_Shigella, Lachnoclostridium, Klebsiella and other potential pathogens were dete...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Weiwen Chen Diming Tan Zixin Yang Jian Tang Weibin Bai Lingmin Tian Source Type: research
Aflatoxins posing threat to food safety and security in Pakistan: Call for a one health approach
Food Chem Toxicol. 2023 Aug 29:114006. doi: 10.1016/j.fct.2023.114006. Online ahead of print.ABSTRACTAflatoxins are among the most important mycotoxins due to their widespread occurrence and adverse impacts on humans and animals. These toxins and/or their metabolites cannot be destroyed with cooking or boiling methods. Therefore, consumption of aflatoxin-contaminated food may lead to impaired growth, compromised immunity, stomach and liver cancer, and acute toxicity. These adverse effects along with food wastage might have detrimental consequences on a country's economy. Several studies from Pakistan reported a high preval...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Waseela Ashraf Abdul Rehman Masood Rabbani Waseem Shaukat Jia-Sheng Wang Source Type: research
