Azole fungicides inhibit human and rat gonadal 3 β-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico docking analysis
Food Chem Toxicol. 2023 Sep 11:114028. doi: 10.1016/j.fct.2023.114028. Online ahead of print.ABSTRACTAzole fungicides are widely used in the agricultural industry to control fungal infections in crops. However, recent studies have shown that some azole fungicides inhibit the activity of 3β-hydroxysteroid dehydrogenases (3β-HSDs) in the gonads. Out of the 16 azole fungicides tested, 8 were found to inhibit human KGN cell 3β-HSD2 with IC50 values of less than 100 μM. The strongest inhibitor was difenoconazole, with an IC50 value of 1.88 μM. In contrast, only 3 of the azole fungicides inhibited rat testicular 3β-HSD1, w...
Source: Food and Chemical Toxicology - September 13, 2023 Category: Food Science Authors: Jianmin Sang Hong Wang Yang Yu Zhongyao Ji Miaomiao Xia Ting Hao Linxi Li Ren-Shan Ge Source Type: research
Combined cytotoxicity of phthalate esters on HepG2 cells: A comprehensive analysis of transcriptomics and metabolomics
Food Chem Toxicol. 2023 Sep 11:114034. doi: 10.1016/j.fct.2023.114034. Online ahead of print.ABSTRACTPhthalate esters (PAEs), widely used as plasticizers, may pose a potential environmental and human hazard. The aim of this study was to compare the cytotoxicity of di(2-ethylhexyl) phthalates (DEHP) and dibutyl phthalate (DBP)) after their exposure to HepG2 cells alone or in combination. HepG2 cells treated with individual/combined DEHP and DBP at a dose of 10-2 M for 24 h were selected for metabolome and transcriptome analysis. The results demonstrated that exposure to the mixtures of DEHP and DBP caused enhanced or reduce...
Source: Food and Chemical Toxicology - September 13, 2023 Category: Food Science Authors: Yanjie Dong Da Cai Chao Liu Shancang Zhao Lei Wang Source Type: research
The effects and mechanisms of the new brominated flame retardant BTBPE on thyroid toxicity
In this study, it was demonstrated that BTBPE in vivo exposure induced FT4 reduction in 2.5, 25 and 250 mg/kg bw treated group and TT4 reduction in 25 mg/kg bw treated group. TG, TPO and NIS are key proteins of thyroid hormone synthesis. The results of Western blot and RT-PCR from thyroid tissue showed decreased protein levels and gene expression levels of TG, TPO and NIS as well as regulatory proteins PAX8 and TTF2. To investigate whether the effect also occurred in humans, anthropogenic Nthy-ori 3-1 cells were selected. Similar results were seen in vitro condition. 2.5 mg/L BTBPE reduced the protein levels of PAX8, TTF1 ...
Source: Food and Chemical Toxicology - September 11, 2023 Category: Food Science Authors: Qiong Zhang Zhenyu Wang Qianqian Xiao Jianhong Ge Xiaoyun Wang Wanyu Jiang Yuese Yuan Yimeng Zhuang Qinghe Meng Jianjun Jiang Weidong Hao Xuetao Wei Source Type: research
Dietary intake of acrylamide in the Norwegian EuroMix biomonitoring study: Comparing probabilistic dietary estimates with haemoglobin adduct measurements
Food Chem Toxicol. 2023 Sep 9:114031. doi: 10.1016/j.fct.2023.114031. Online ahead of print.ABSTRACTAcrylamide is a probable human carcinogen with widespread exposure via food. The present study compared acrylamide intake measurements obtained from haemoglobin adduct levels and self-registered dietary consumption data in a group of 144 Norwegian healthy adults. Acrylamide adducts to N-terminal valine in haemoglobin were measured and used to estimate the intake via the internal dose approach which showed a median (interquartile range) of 0.24 (0.19-0.30) μg/kg bw/day. Data from weighed food records and food frequency quest...
Source: Food and Chemical Toxicology - September 11, 2023 Category: Food Science Authors: Efstathios Vryonidis Margareta T örnqvist Oddvar Myhre Hubert Dirven Trine Hus øy Source Type: research
The effects and mechanisms of the new brominated flame retardant BTBPE on thyroid toxicity
In this study, it was demonstrated that BTBPE in vivo exposure induced FT4 reduction in 2.5, 25 and 250 mg/kg bw treated group and TT4 reduction in 25 mg/kg bw treated group. TG, TPO and NIS are key proteins of thyroid hormone synthesis. The results of Western blot and RT-PCR from thyroid tissue showed decreased protein levels and gene expression levels of TG, TPO and NIS as well as regulatory proteins PAX8 and TTF2. To investigate whether the effect also occurred in humans, anthropogenic Nthy-ori 3-1 cells were selected. Similar results were seen in vitro condition. 2.5 mg/L BTBPE reduced the protein levels of PAX8, TTF1 ...
Source: Food and Chemical Toxicology - September 11, 2023 Category: Food Science Authors: Qiong Zhang Zhenyu Wang Qianqian Xiao Jianhong Ge Xiaoyun Wang Wanyu Jiang Yuese Yuan Yimeng Zhuang Qinghe Meng Jianjun Jiang Weidong Hao Xuetao Wei Source Type: research
Dietary intake of acrylamide in the Norwegian EuroMix biomonitoring study: Comparing probabilistic dietary estimates with haemoglobin adduct measurements
Food Chem Toxicol. 2023 Sep 9:114031. doi: 10.1016/j.fct.2023.114031. Online ahead of print.ABSTRACTAcrylamide is a probable human carcinogen with widespread exposure via food. The present study compared acrylamide intake measurements obtained from haemoglobin adduct levels and self-registered dietary consumption data in a group of 144 Norwegian healthy adults. Acrylamide adducts to N-terminal valine in haemoglobin were measured and used to estimate the intake via the internal dose approach which showed a median (interquartile range) of 0.24 (0.19-0.30) μg/kg bw/day. Data from weighed food records and food frequency quest...
Source: Food and Chemical Toxicology - September 11, 2023 Category: Food Science Authors: Efstathios Vryonidis Margareta T örnqvist Oddvar Myhre Hubert Dirven Trine Hus øy Source Type: research
Evaluation of in vitro bioassays as a screening tool to monitor chemical hazards in cow's milk
Food Chem Toxicol. 2023 Sep 7:114025. doi: 10.1016/j.fct.2023.114025. Online ahead of print.ABSTRACTStudies on cow's milk have mainly focused on analyzing specific chemical groups and natural components. Therefore, in this study, we evaluated if effect-based in vitro methods could be used as a screening tool to monitor chemical hazards in milk. In total, 32 milk samples were collected from a Swedish dairy company throughout one year. These samples included conventional and organic semi-skimmed as well as raw milk. The milk samples were tested in five in vitro methods covering eight endpoints. These endpoints included cytot...
Source: Food and Chemical Toxicology - September 9, 2023 Category: Food Science Authors: Erica Selin Geeta Mandava Maria Karlsson Johan Lundqvist Source Type: research
Oxidative stress-affected ACSL1 hydroxymethylation triggered benzene hematopoietic toxicity by inflammation and senescence
Food Chem Toxicol. 2023 Sep 7:114030. doi: 10.1016/j.fct.2023.114030. Online ahead of print.ABSTRACTLong-term benzene exposure is harmful and causes hematopoietic dysfunction. However, the mechanism of benzene hematopoietic toxicity is still unclear. Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) has been found to participate in the progress of a variety of benign and malignant diseases, but there is no research about its effect on benzene-induced hematopoietic toxicity. Herein, We exposed C57BL/6J mice to benzene to construct an in vivo model. Human peripheral blood mononuclear cells (THP-1 cells) were treated wit...
Source: Food and Chemical Toxicology - September 9, 2023 Category: Food Science Authors: Ziyan Liu Xiaoli Guo Wei Zhang Jingyu Wang Lei Zhang Jiaru Jing Lin Han Ai Gao Source Type: research
Evaluation of in vitro bioassays as a screening tool to monitor chemical hazards in cow's milk
Food Chem Toxicol. 2023 Sep 7:114025. doi: 10.1016/j.fct.2023.114025. Online ahead of print.ABSTRACTStudies on cow's milk have mainly focused on analyzing specific chemical groups and natural components. Therefore, in this study, we evaluated if effect-based in vitro methods could be used as a screening tool to monitor chemical hazards in milk. In total, 32 milk samples were collected from a Swedish dairy company throughout one year. These samples included conventional and organic semi-skimmed as well as raw milk. The milk samples were tested in five in vitro methods covering eight endpoints. These endpoints included cytot...
Source: Food and Chemical Toxicology - September 9, 2023 Category: Food Science Authors: Erica Selin Geeta Mandava Maria Karlsson Johan Lundqvist Source Type: research
Oxidative stress-affected ACSL1 hydroxymethylation triggered benzene hematopoietic toxicity by inflammation and senescence
Food Chem Toxicol. 2023 Sep 7:114030. doi: 10.1016/j.fct.2023.114030. Online ahead of print.ABSTRACTLong-term benzene exposure is harmful and causes hematopoietic dysfunction. However, the mechanism of benzene hematopoietic toxicity is still unclear. Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) has been found to participate in the progress of a variety of benign and malignant diseases, but there is no research about its effect on benzene-induced hematopoietic toxicity. Herein, We exposed C57BL/6J mice to benzene to construct an in vivo model. Human peripheral blood mononuclear cells (THP-1 cells) were treated wit...
Source: Food and Chemical Toxicology - September 9, 2023 Category: Food Science Authors: Ziyan Liu Xiaoli Guo Wei Zhang Jingyu Wang Lei Zhang Jiaru Jing Lin Han Ai Gao Source Type: research
Normolipidic diet containing deep-fried saturated and unsaturated fatty acids rich edible oils promotes metabolic dysregulation and inflammatory microenvironment in Wistar rats
This study investigated the influence of prolonged consumption of thermally oxidised long-chain saturated and unsaturated edible oils on metabolic dysregulation and inflammation. The thermally oxidised oils used in the study possess higher p-anisidine values and free fatty acid contents compared to unoxidised oils. Fourier transform infrared spectroscopy and fatty acid methyl ester analysis confirmed the presence of free fatty acids, hydroperoxides, and aldehydes, formed during thermal oxidation. The study analysed the effects of dietary intake of 5% sunflower oil, palm oil, and their thermally-oxidised forms in male Wista...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Sruthi Panniyan Kandiyil Soorya Parathodi Illam Achuthan C Raghavamenon Source Type: research
Predicting chemicals' toxicity pathway of female reproductive disorders using AOP7 and deep neural networks
Food Chem Toxicol. 2023 Sep 6:114013. doi: 10.1016/j.fct.2023.114013. Online ahead of print.ABSTRACTExperimental evidence shows that certain chemicals, particularly endocrine disrupting chemicals, may negatively affect the female reproductive system, thereby lowering women's fertility. However, humans are constantly exposed to a number of different chemicals with limited or no experimental data regarding their effect and the mechanism of action in the female reproductive system. To predict chemical hazards to the female reproductive system, we used a previously defined adverse outcome pathway (AOP) that links activation of...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Nata ša Sukur Nemanja Milo šević Kristina Pogrmic-Majkic Bojana Stanic Nebojsa Andric Source Type: research
Normolipidic diet containing deep-fried saturated and unsaturated fatty acids rich edible oils promotes metabolic dysregulation and inflammatory microenvironment in Wistar rats
This study investigated the influence of prolonged consumption of thermally oxidised long-chain saturated and unsaturated edible oils on metabolic dysregulation and inflammation. The thermally oxidised oils used in the study possess higher p-anisidine values and free fatty acid contents compared to unoxidised oils. Fourier transform infrared spectroscopy and fatty acid methyl ester analysis confirmed the presence of free fatty acids, hydroperoxides, and aldehydes, formed during thermal oxidation. The study analysed the effects of dietary intake of 5% sunflower oil, palm oil, and their thermally-oxidised forms in male Wista...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Sruthi Panniyan Kandiyil Soorya Parathodi Illam Achuthan C Raghavamenon Source Type: research
Predicting chemicals' toxicity pathway of female reproductive disorders using AOP7 and deep neural networks
Food Chem Toxicol. 2023 Sep 6:114013. doi: 10.1016/j.fct.2023.114013. Online ahead of print.ABSTRACTExperimental evidence shows that certain chemicals, particularly endocrine disrupting chemicals, may negatively affect the female reproductive system, thereby lowering women's fertility. However, humans are constantly exposed to a number of different chemicals with limited or no experimental data regarding their effect and the mechanism of action in the female reproductive system. To predict chemical hazards to the female reproductive system, we used a previously defined adverse outcome pathway (AOP) that links activation of...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Nata ša Sukur Nemanja Milo šević Kristina Pogrmic-Majkic Bojana Stanic Nebojsa Andric Source Type: research
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity
Food Chem Toxicol. 2023 Sep 2;180:114012. doi: 10.1016/j.fct.2023.114012. Online ahead of print.ABSTRACTIn order to investigate the amelioration of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on bisphenol A (BPA)-induced nephrotoxicity, the murine nephrotoxicity model was established by intragastric administration of BPA (5 mg/kg/B.W.) for 6 weeks. The biochemical indices, hematoxylin-eosin (H&E) staining, kidney metabolomics, and related protein expression levels of SIRT1-AMPK pathway were then determined. Our results indicated that DHA-PS (100 mg/kg/B.W.) ameliorated the BPA-induced nephrotoxicity after...
Source: Food and Chemical Toxicology - September 4, 2023 Category: Food Science Authors: Qiuyan Pu Fei Yang Rui Zhao Su Jiang Yunping Tang Tao Han Source Type: research
