Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway
In this study, rats were used as an animal model to investigate the effects of HFPO-TA on liver glucose and lipid metabolism. We found that HFPO-TA can affect glucose tolerance. Through omics analysis and molecular detection, it was found that HFPO-TA mainly affects the PPAR signaling pathway in the liver of rats, inhibiting liver glycolysis while promoting glucose production. HFPO-TA not only promotes the synthesis of fatty acids in the liver, but also promotes the breakdown of fatty acids, which ultimately leads to the disruption of hepatic glucose and lipid metabolism. The effects of HFPO-TA on metabolism are discussed ...
Source: Food and Chemical Toxicology - April 7, 2024 Category: Food Science Authors: Xuemin Zhang Zhi Li Mingqing Qian Bingya Zhang Hongxia Zhang Li Wang Hui Liu Source Type: research
Advancing the allergenicity assessment of new proteins using a text mining resource
Food Chem Toxicol. 2024 Apr 4;187:114638. doi: 10.1016/j.fct.2024.114638. Online ahead of print.ABSTRACTWith a society increasingly demanding alternative protein food sources, new strategies for evaluating protein safety issues, such as allergenic potential, are needed. Large-scale and systemic studies on allergenic proteins are hindered by the limited and non-harmonized clinical information available for these substances in dedicated databases. A missing key information is that representing the symptomatology of the allergens, especially given in terms of standard vocabularies, that would allow connecting with other biome...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Jorge Novoa Antonio Fernandez-Dumont E N Clare Mills F Javier Moreno Florencio Pazos Source Type: research
Per- and polyfluoroalkyls used as cosmetic ingredients - Qualitative study of 765 cosmetic products
Food Chem Toxicol. 2024 Apr 4:114625. doi: 10.1016/j.fct.2024.114625. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFAS) form a vast family comprising more than 4700 synthetic compounds. Their molecules contain a terminal functional group and a hydrophobic carbon tail (alkyl group) at which the hydrogen atoms are totally (in the case of perfluorinated compounds) or partially (in the case of polyfluorinated compounds) replaced by fluorine atoms. Due to the very specific properties of their structure, they have been used in a vast range of applications over the last 70 years. These substances are consid...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Couteau C éline Brunet Catherine Clarke Romane Coiffard Laurence Source Type: research
Potential impact of underlying diseases influencing ADME in nonclinical safety assessment
Food Chem Toxicol. 2024 Apr 4:114636. doi: 10.1016/j.fct.2024.114636. Online ahead of print.ABSTRACTNonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory requirements by a national or international authority. In this review, we summarize the potential effects of various underlying diseases governing the absorption, distribution, metabolism, and excretion (ADME) of drugs to consider the use of animal models of diseases in nonclinical trials. Obesity models showed alterations in hepatic metabolizing enzymes, ...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Sumin Cho Harin Jo Yeon Jeong Hwang Changuk Kim Yong Hyeon Jo Jun-Won Yun Source Type: research
The relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
Food Chem Toxicol. 2024 Apr 4:114634. doi: 10.1016/j.fct.2024.114634. Online ahead of print.ABSTRACTThe purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were formed. The first group received mad honey (80 mg/kg), the second group received normal honey (80 mg/kg), and the third group was the control. The first and second groups received normal and mad honey by oral gavage for 30 days before being sacrificed under anesthesia. Caspase 3 immunostaining showed a moder...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Hayrunnisa Ye şil Sarsmaz Seren G ülşen Gürgen Ali Cansu S üha Türkmen Abd ülkadir Gündüz Source Type: research
Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF- κB/NLRP3/GSDMD signaling pathways
Food Chem Toxicol. 2024 Apr 4:114637. doi: 10.1016/j.fct.2024.114637. Online ahead of print.ABSTRACTDiclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug therapy to protect against such AKI is still needed. Diacetylrhein (DAR), an anthraquinone derivative, has different antioxidant and anti-inflammatory properties. Therefore, the aim of the current study was to investigate the renoprotective effect of DAR on DF-induced AKI while elucidating the potential underlying mechanism. Our results showed th...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Update to RIFM fragrance ingredient safety assessment, 4-methyloctanoic acid, CAS Registry Number 54947-74-9
Food Chem Toxicol. 2024 Apr 4:114643. doi: 10.1016/j.fct.2024.114643. Online ahead of print.NO ABSTRACTPMID:38582346 | DOI:10.1016/j.fct.2024.114643 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Longitudinal changes in adverse effects reporting in multiple dietary supplement classifications: The US military dietary supplement use study
In conclusion, AEs reported at baseline did not deter many participants from using DSs in the follow-up period, and many SMs reporting AEs at baseline continued reporting them at follow-up.PMID:38582347 | DOI:10.1016/j.fct.2024.114635 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Joseph J Knapik Daniel W Trone Ryan A Steelman Harris R Lieberman Source Type: research
Advancing the allergenicity assessment of new proteins using a text mining resource
Food Chem Toxicol. 2024 Apr 4:114638. doi: 10.1016/j.fct.2024.114638. Online ahead of print.ABSTRACTWith a society increasingly demanding alternative protein food sources, new strategies for evaluating protein safety issues, such as allergenic potential, are needed. Large-scale and systemic studies on allergenic proteins are hindered by the limited and non-harmonized clinical information available for these substances in dedicated databases. A missing key information is that representing the symptomatology of the allergens, especially given in terms of standard vocabularies, that would allow connecting with other biomedica...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Jorge Novoa Antonio Fernandez-Dumont E N Clare Mills F Javier Moreno Florencio Pazos Source Type: research
Per- and polyfluoroalkyls used as cosmetic ingredients - Qualitative study of 765 cosmetic products
Food Chem Toxicol. 2024 Apr 4:114625. doi: 10.1016/j.fct.2024.114625. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFAS) form a vast family comprising more than 4700 synthetic compounds. Their molecules contain a terminal functional group and a hydrophobic carbon tail (alkyl group) at which the hydrogen atoms are totally (in the case of perfluorinated compounds) or partially (in the case of polyfluorinated compounds) replaced by fluorine atoms. Due to the very specific properties of their structure, they have been used in a vast range of applications over the last 70 years. These substances are consid...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Couteau C éline Brunet Catherine Clarke Romane Coiffard Laurence Source Type: research
Potential impact of underlying diseases influencing ADME in nonclinical safety assessment
Food Chem Toxicol. 2024 Apr 4:114636. doi: 10.1016/j.fct.2024.114636. Online ahead of print.ABSTRACTNonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory requirements by a national or international authority. In this review, we summarize the potential effects of various underlying diseases governing the absorption, distribution, metabolism, and excretion (ADME) of drugs to consider the use of animal models of diseases in nonclinical trials. Obesity models showed alterations in hepatic metabolizing enzymes, ...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Sumin Cho Harin Jo Yeon Jeong Hwang Changuk Kim Yong Hyeon Jo Jun-Won Yun Source Type: research
The relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
Food Chem Toxicol. 2024 Apr 4:114634. doi: 10.1016/j.fct.2024.114634. Online ahead of print.ABSTRACTThe purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were formed. The first group received mad honey (80 mg/kg), the second group received normal honey (80 mg/kg), and the third group was the control. The first and second groups received normal and mad honey by oral gavage for 30 days before being sacrificed under anesthesia. Caspase 3 immunostaining showed a moder...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Hayrunnisa Ye şil Sarsmaz Seren G ülşen Gürgen Ali Cansu S üha Türkmen Abd ülkadir Gündüz Source Type: research
Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF- κB/NLRP3/GSDMD signaling pathways
Food Chem Toxicol. 2024 Apr 4:114637. doi: 10.1016/j.fct.2024.114637. Online ahead of print.ABSTRACTDiclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug therapy to protect against such AKI is still needed. Diacetylrhein (DAR), an anthraquinone derivative, has different antioxidant and anti-inflammatory properties. Therefore, the aim of the current study was to investigate the renoprotective effect of DAR on DF-induced AKI while elucidating the potential underlying mechanism. Our results showed th...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Update to RIFM fragrance ingredient safety assessment, 4-methyloctanoic acid, CAS Registry Number 54947-74-9
Food Chem Toxicol. 2024 Apr 4:114643. doi: 10.1016/j.fct.2024.114643. Online ahead of print.NO ABSTRACTPMID:38582346 | DOI:10.1016/j.fct.2024.114643 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Longitudinal changes in adverse effects reporting in multiple dietary supplement classifications: The US military dietary supplement use study
In conclusion, AEs reported at baseline did not deter many participants from using DSs in the follow-up period, and many SMs reporting AEs at baseline continued reporting them at follow-up.PMID:38582347 | DOI:10.1016/j.fct.2024.114635 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Joseph J Knapik Daniel W Trone Ryan A Steelman Harris R Lieberman Source Type: research
