Deoxynivalenol leads to endoplasmic reticulum stress-mediated apoptosis via the IRE1/JNK/CHOP pathways in porcine embryos
In conclusion, DON exposure impairs the developmental ability of porcine embryos by inducing ER stress-mediated apoptosis via IRE1/JNK/CHOP signaling.PMID:38608924 | DOI:10.1016/j.fct.2024.114633 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Ye-Won Kim Seul-Gi Yang Byoung-Boo Seo Deog-Bon Koo Hyo-Jin Park Source Type: research
RIFM fragrance ingredient safety assessment, benzonitrile, 3,4-dimethyl-, CAS Registry Number 22884-95-3
Food Chem Toxicol. 2024 Apr 10:114648. doi: 10.1016/j.fct.2024.114648. Online ahead of print.NO ABSTRACTPMID:38608925 | DOI:10.1016/j.fct.2024.114648 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Risk Assessment of Feed Components of Botanical Origin - Approaches taken in the European Union
Food Chem Toxicol. 2024 Apr 10:114654. doi: 10.1016/j.fct.2024.114654. Online ahead of print.ABSTRACTIn view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of target animals and of consumers to animal derived food via carry-over from feed. Relevant regulatory frameworks for feed additi...
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Birgit Dusemund Gabriele Aquilina Maria de Lourdes Bastos Francesca Marcon Fabiola Pizzo Ruud Woutersen Paola Manini Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 2-methylpentanoate, CAS Registry Number 39255-32-8
Food Chem Toxicol. 2024 Apr 9:114651. doi: 10.1016/j.fct.2024.114651. Online ahead of print.NO ABSTRACTPMID:38604576 | DOI:10.1016/j.fct.2024.114651 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 3,5,5-trimethylhexanoate, CAS Registry Number 67707-75-9
Food Chem Toxicol. 2024 Apr 9:114646. doi: 10.1016/j.fct.2024.114646. Online ahead of print.NO ABSTRACTPMID:38604578 | DOI:10.1016/j.fct.2024.114646 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3
Food Chem Toxicol. 2024 Apr 10;189 Suppl 1:114641. doi: 10.1016/j.fct.2024.114641. Online ahead of print.NO ABSTRACTPMID:38604579 | DOI:10.1016/j.fct.2024.114641 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS registry number 78-37-5
Food Chem Toxicol. 2024 Apr 9:114645. doi: 10.1016/j.fct.2024.114645. Online ahead of print.NO ABSTRACTPMID:38604580 | DOI:10.1016/j.fct.2024.114645 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, 3,6-nonadien-1-ol, CAS Registry Number 76649-25-7
Food Chem Toxicol. 2024 Apr 9:114642. doi: 10.1016/j.fct.2024.114642. Online ahead of print.NO ABSTRACTPMID:38604581 | DOI:10.1016/j.fct.2024.114642 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 2-methylpentanoate, CAS Registry Number 39255-32-8
Food Chem Toxicol. 2024 Apr 9:114651. doi: 10.1016/j.fct.2024.114651. Online ahead of print.NO ABSTRACTPMID:38604576 | DOI:10.1016/j.fct.2024.114651 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 3,5,5-trimethylhexanoate, CAS Registry Number 67707-75-9
Food Chem Toxicol. 2024 Apr 9:114646. doi: 10.1016/j.fct.2024.114646. Online ahead of print.NO ABSTRACTPMID:38604578 | DOI:10.1016/j.fct.2024.114646 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3
Food Chem Toxicol. 2024 Apr 9:114641. doi: 10.1016/j.fct.2024.114641. Online ahead of print.NO ABSTRACTPMID:38604579 | DOI:10.1016/j.fct.2024.114641 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS registry number 78-37-5
Food Chem Toxicol. 2024 Apr 9:114645. doi: 10.1016/j.fct.2024.114645. Online ahead of print.NO ABSTRACTPMID:38604580 | DOI:10.1016/j.fct.2024.114645 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, 3,6-nonadien-1-ol, CAS Registry Number 76649-25-7
Food Chem Toxicol. 2024 Apr 9:114642. doi: 10.1016/j.fct.2024.114642. Online ahead of print.NO ABSTRACTPMID:38604581 | DOI:10.1016/j.fct.2024.114642 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
