Evaluation of the cytotoxicity and genotoxicity potential of synthetic diacetyl food flavoring in silico, in vivo, and in vitro
Food Chem Toxicol. 2023 Jul 1:113923. doi: 10.1016/j.fct.2023.113923. Online ahead of print.ABSTRACTDiacetyl is a common ingredient that creates a buttery flavor in baked goods and other food products. The cytotoxic impact of diacetyl on a normal human liver cell line (THLE2) indicated an IC50 value of 41.29 mg/ml through MTT assay and a cell cycle arrest in the G0/G1 phase relative to the control. Administration of diacetyl at two-time points (acute-chronic) led to a significant increase in DNA damage indicated by the increase in tail length, tail DNA%, and tail moment. The mRNA and protein expression levels of genes in t...
Source: Food and Chemical Toxicology - July 3, 2023 Category: Food Science Authors: Mohamed Salama Dina Mostafa Mohammed Khaled Fahmy Neima K Al-Senosy Naglaa M Ebeed Amr Farouk Source Type: research
V-ATPase V0 subunit activation mediates maduramicin-induced methuosis through blocking endolysosomal trafficking in vitro and in vivo
Food Chem Toxicol. 2023 Jun 30:113922. doi: 10.1016/j.fct.2023.113922. Online ahead of print.ABSTRACTMethuosis, a novel cell death phenotype, is characterized by accumulation of cytoplasmic vacuolization upon external stimulus. Methuosis plays a critical role in maduramicin-induced cardiotoxicity despite the underlying mechanism is largely unknown. Herein, we aimed to investigate the origin and intracellular trafficking of cytoplasmic vacuoles, as well as the molecular mechanism of methuosis caused by maduramicin (1 μg/mL) in myocardial cells. H9c2 cells and broiler chicken were used and were exposed to maduramicin at dos...
Source: Food and Chemical Toxicology - July 2, 2023 Category: Food Science Authors: Yuling Zheng Jing Xiao Junqi Wang Bin Dong Dawei Guo Hui Ji Haifeng Sun Lin Peng Shanxiang Jiang Xiuge Gao Source Type: research
V-ATPase V0 subunit activation mediates maduramicin-induced methuosis through blocking endolysosomal trafficking in vitro and in vivo
Food Chem Toxicol. 2023 Jun 30:113922. doi: 10.1016/j.fct.2023.113922. Online ahead of print.ABSTRACTMethuosis, a novel cell death phenotype, is characterized by accumulation of cytoplasmic vacuolization upon external stimulus. Methuosis plays a critical role in maduramicin-induced cardiotoxicity despite the underlying mechanism is largely unknown. Herein, we aimed to investigate the origin and intracellular trafficking of cytoplasmic vacuoles, as well as the molecular mechanism of methuosis caused by maduramicin (1 μg/mL) in myocardial cells. H9c2 cells and broiler chicken were used and were exposed to maduramicin at dos...
Source: Food and Chemical Toxicology - July 2, 2023 Category: Food Science Authors: Yuling Zheng Jing Xiao Junqi Wang Bin Dong Dawei Guo Hui Ji Haifeng Sun Lin Peng Shanxiang Jiang Xiuge Gao Source Type: research
Necroptosis and NLPR3 inflammasome activation mediated by ROS/JNK pathway participate in AlCl < sub > 3 < /sub > -induced kidney damage
In conclusion, these findings suggest that necroptosis and NLPR3 inflammasome activation mediated by ROS/JNK pathway participate in AlCl3-induced kidney damage.PMID:37393014 | DOI:10.1016/j.fct.2023.113915 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 1, 2023 Category: Food Science Authors: Jiayu Du Xuliang Zhang Jian Zhang Siming Huo Bo Li Qi Wang Miao Song Bing Shao Yanfei Li Source Type: research
Hepatoprotective and anti-hyperglycemic effects of ferulic acid in arsenic-exposed mice
In conclusion, FA prevented SA-induced glucose intolerance and hepatotoxicity by reducing oxidative stress, inflammation, and hepatic overexpression of PPAR-γ and GLUT2 proteins.PMID:37393015 | DOI:10.1016/j.fct.2023.113924 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 1, 2023 Category: Food Science Authors: Mahdi Daryagasht Mehrnoosh Moosavi Layasadat Khorsandi Reza Azadnasab Mohammad Javad Khodayar Source Type: research
Hepatotoxicity screening and ranking of structurally different pyrrolizidine alkaloids in zebrafish
In this study, a zebrafish model, which mimics physiological processes of absorption, distribution, metabolism, and excretion, was selected to evaluate acute hepatotoxic potency of different PAs (7 PAs and 2 PA N-oxides) and explore possible physiological pathways involved in PA-induced hepatotoxicity. After 6 h oral administration, PAs caused distinct structure-dependent hepatotoxicity with a series of biochemical and histological changes in zebrafish. Based on the measured toxicological endpoints, the relative toxic potency order of different PAs was derived as lasiocarpine ∼ retrorsine > monocrotaline > riddelli...
Source: Food and Chemical Toxicology - June 30, 2023 Category: Food Science Authors: Yueyang Pan Jiang Ma Hui Zhao Peter P Fu Ge Lin Source Type: research
The prevalence and concentration of ochratoxin A in meat and edible offal: A global systematic review and meta-analysis
Food Chem Toxicol. 2023 Jun 28;178:113921. doi: 10.1016/j.fct.2023.113921. Online ahead of print.ABSTRACTThe prevalence of ochratoxin A (OTA) in meat, edible offal, and meat products (MOP) was assessed through systematic review and meta-analysis. Four electronic databases were used to gather data from 1975 to September 15, 2022. Seventy-five articles comprising 8585 samples were identified and analyzed. The studies included in the analysis were conducted at a global level, with a predominant focus on Europe [72% (54/75)], Asia [13.33% (10/75)], Africa [13.33% (10/75)], and North America [1.33% (1/75)]. The overall prevalen...
Source: Food and Chemical Toxicology - June 30, 2023 Category: Food Science Authors: Houshmand Sharafi Negar Alizadeh Mehran Moradi Kiomars Sharafi Amin Mousavi Khaneghah Source Type: research
Hepatotoxicity screening and ranking of structurally different pyrrolizidine alkaloids in zebrafish
In this study, a zebrafish model, which mimics physiological processes of absorption, distribution, metabolism, and excretion, was selected to evaluate acute hepatotoxic potency of different PAs (7 PAs and 2 PA N-oxides) and explore possible physiological pathways involved in PA-induced hepatotoxicity. After 6 h oral administration, PAs caused distinct structure-dependent hepatotoxicity with a series of biochemical and histological changes in zebrafish. Based on the measured toxicological endpoints, the relative toxic potency order of different PAs was derived as lasiocarpine ∼ retrorsine > monocrotaline > riddelli...
Source: Food and Chemical Toxicology - June 30, 2023 Category: Food Science Authors: Yueyang Pan Jiang Ma Hui Zhao Peter P Fu Ge Lin Source Type: research
The prevalence and concentration of ochratoxin A in meat and edible offal: A global systematic review and meta-analysis
Food Chem Toxicol. 2023 Jun 28:113921. doi: 10.1016/j.fct.2023.113921. Online ahead of print.ABSTRACTThe prevalence of ochratoxin A (OTA) in meat, edible offal, and meat products (MOP) was assessed through systematic review and meta-analysis. Four electronic databases were used to gather data from 1975 to September 15, 2022. Seventy-five articles comprising 8585 samples were identified and analyzed. The studies included in the analysis were conducted at a global level, with a predominant focus on Europe [72% (54/75)], Asia [13.33% (10/75)], Africa [13.33% (10/75)], and North America [1.33% (1/75)]. The overall prevalence o...
Source: Food and Chemical Toxicology - June 30, 2023 Category: Food Science Authors: Houshmand Sharafi Negar Alizadeh Mehran Moradi Kiomars Sharafi Amin Mousavi Khaneghah Source Type: research
RIFM fragrance ingredient safety assessment, isobutyl salicylate, CAS Registry Number 87-19-4
Food Chem Toxicol. 2023 Jun 27:113909. doi: 10.1016/j.fct.2023.113909. Online ahead of print.NO ABSTRACTPMID:37385328 | DOI:10.1016/j.fct.2023.113909 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 29, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice
Food Chem Toxicol. 2023 Jun 27:113908. doi: 10.1016/j.fct.2023.113908. Online ahead of print.ABSTRACTTriclocarban (TCC) is an antibacterial component widely used in personal care products with potential toxicity possessing public health issues. Unfortunately, enterotoxicity mechanisms of TCC exposure remain largely unknown. Using a combination of 16S rRNA gene sequencing, metabolomics, histopathological and biological examinations, this study systematically explored the deteriorating effects of TCC exposure on a dextran sulfate sodium (DSS)-induced colitis mouse model. We found that TCC exposure at different doses signific...
Source: Food and Chemical Toxicology - June 29, 2023 Category: Food Science Authors: Mengyu Qin Hehua Lei Yuchen Song Mengjing Wu Chuan Chen Zheng Cao Cui Zhang Ruichen Du Ce Zhang Xian Wang Limin Zhang Source Type: research
RIFM fragrance ingredient safety assessment, isobutyl salicylate, CAS Registry Number 87-19-4
Food Chem Toxicol. 2023 Jun 27:113909. doi: 10.1016/j.fct.2023.113909. Online ahead of print.NO ABSTRACTPMID:37385328 | DOI:10.1016/j.fct.2023.113909 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 29, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice
Food Chem Toxicol. 2023 Jun 27:113908. doi: 10.1016/j.fct.2023.113908. Online ahead of print.ABSTRACTTriclocarban (TCC) is an antibacterial component widely used in personal care products with potential toxicity possessing public health issues. Unfortunately, enterotoxicity mechanisms of TCC exposure remain largely unknown. Using a combination of 16S rRNA gene sequencing, metabolomics, histopathological and biological examinations, this study systematically explored the deteriorating effects of TCC exposure on a dextran sulfate sodium (DSS)-induced colitis mouse model. We found that TCC exposure at different doses signific...
Source: Food and Chemical Toxicology - June 29, 2023 Category: Food Science Authors: Mengyu Qin Hehua Lei Yuchen Song Mengjing Wu Chuan Chen Zheng Cao Cui Zhang Ruichen Du Ce Zhang Xian Wang Limin Zhang Source Type: research
Update to RIFM fragrance ingredient safety assessment, propyl phenethyl acetal, CAS registry number 7493-57-4
Food Chem Toxicol. 2023 Jun 26:113911. doi: 10.1016/j.fct.2023.113911. Online ahead of print.NO ABSTRACTPMID:37379896 | DOI:10.1016/j.fct.2023.113911 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 28, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Asparanin A exerts cytotoxicity on human endometrial cancer Ishikawa cells via regulating miR-6236-p5_4 expression
Food Chem Toxicol. 2023 Jun 25;178:113900. doi: 10.1016/j.fct.2023.113900. Online ahead of print.ABSTRACTmiRNAs are emerging as a novel proto-oncogene or tumor suppressor in the initiation and progression of cancer. Several plants naturally contain asparanin A (AA), which has potent anticancer properties. Previously, we discovered that AA exposure increased the expression of miR-6236-p5_4 and caused cytotoxicity in endometrial carcinoma (EC) Ishikawa cells. Herein, the regulation mechanism of miR-6236-p5_4 in the anticancer activity of AA in EC was investigated. Our results showed that the overexpressed miR-6236-p5_4 contr...
Source: Food and Chemical Toxicology - June 27, 2023 Category: Food Science Authors: Fan Zhang Xiu-Xiu Zhang Jian-Guo Zhang Kiran Thakur Jesus Simal-Gandara Miguel A Prieto Mohammad Rizwan Khan Hui Cao Zhao-Jun Wei Source Type: research
