Understanding fenpropathrin-induced pulmonary toxicity: What apoptosis, inflammation, and pyreptosis reveal analyzing cross-links at the molecular, immunohistochemical, and immunofluorescent levels
In conclusion, this study shows the potential pulmonary toxicity after FN oral ingestion, and the prominent preventive ability of CCM-Chs more than CCM in combatting the pulmonary toxicity induced by FN. This may be beneficial in developing therapeutic and preventive strategies against FN-induced pulmonary toxicity.PMID:38369055 | DOI:10.1016/j.fct.2024.114520 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 18, 2024 Category: Food Science Authors: Amany Abdel-Rahman Mohamed Yasmina M Abd El-Hakim Ahmed E Noreldin Tarek Khamis Moustafa Elhamouly Mohamed A Akela Badriyah S Alotaibi Manal Alosaimi Samah S Khalil Mohamed El-Gamal Naief Dahran Eman S El-Shetry Source Type: research
Rapamycin protects Sertoli cells against BPA-induced autophagy disorders
Food Chem Toxicol. 2024 Feb 14:114510. doi: 10.1016/j.fct.2024.114510. Online ahead of print.ABSTRACTBisphenol A (BPA) is a well-known environmental contaminant that can negatively impact reproductive function. Disruption of autophagy is implicated in BPA-induced cell injury, the specific molecular mechanisms through which BPA affects autophagy in Sertoli cells are still unknown. In the present study, TM4 cells were exposed to various doses of BPA (10, 100, and 200 μM), and the results indicated that BPA exposure led to the accumulation of autophagosomes, this change was accompanied by increased expression of p-mTOR and d...
Source: Food and Chemical Toxicology - February 16, 2024 Category: Food Science Authors: Junyu Nie Zhimin Mao Xuhui Zeng Xiuling Zhao Source Type: research
Rapamycin protects Sertoli cells against BPA-induced autophagy disorders
Food Chem Toxicol. 2024 Feb 14:114510. doi: 10.1016/j.fct.2024.114510. Online ahead of print.ABSTRACTBisphenol A (BPA) is a well-known environmental contaminant that can negatively impact reproductive function. Disruption of autophagy is implicated in BPA-induced cell injury, the specific molecular mechanisms through which BPA affects autophagy in Sertoli cells are still unknown. In the present study, TM4 cells were exposed to various doses of BPA (10, 100, and 200 μM), and the results indicated that BPA exposure led to the accumulation of autophagosomes, this change was accompanied by increased expression of p-mTOR and d...
Source: Food and Chemical Toxicology - February 16, 2024 Category: Food Science Authors: Junyu Nie Zhimin Mao Xuhui Zeng Xiuling Zhao Source Type: research
Demethoxylation of curcumin enhances its inhibition on human and rat 17 β-hydroxysteroid dehydrogenase 3: QSAR structure-activity relationship and in silico docking analysis
In conclusion, curcuminoids and their metabolites possess the ability to inhibit androgen biosynthesis by directly targeting human and rat 17β-HSD3. The inhibitory strength of these compounds is influenced by their lipophilicity and ionization characteristics.PMID:38360388 | DOI:10.1016/j.fct.2024.114489 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 15, 2024 Category: Food Science Authors: Zhongyao Ji Jianmin Sang Hong Wang Miaomiao Xia Ting Hao Liping Chen Han Lu Shaowei Wang Ming Yao Linxi Li Ren-Shan Ge Source Type: research
Toxicogenomics of the C-C chemokine receptor type 5 (CCR5): Exploring the potential impacts of chemical-CCR5 interactions on inflammation and human health
In conclusion, CTD data showed that environmental contaminants indeed affect CCR5 expression, with a tendency towards increased expression. The interaction of environmental contaminants with other chemokine receptor genes may potentialize their toxic effects on the chemokine system, favoring inflammation.PMID:38360389 | DOI:10.1016/j.fct.2024.114511 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 15, 2024 Category: Food Science Authors: Joel Henrique Ellwanger Jos é Artur Bogo Chies Source Type: research
Demethoxylation of curcumin enhances its inhibition on human and rat 17 β-hydroxysteroid dehydrogenase 3: QSAR structure-activity relationship and in silico docking analysis
In conclusion, curcuminoids and their metabolites possess the ability to inhibit androgen biosynthesis by directly targeting human and rat 17β-HSD3. The inhibitory strength of these compounds is influenced by their lipophilicity and ionization characteristics.PMID:38360388 | DOI:10.1016/j.fct.2024.114489 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 15, 2024 Category: Food Science Authors: Zhongyao Ji Jianmin Sang Hong Wang Miaomiao Xia Ting Hao Liping Chen Han Lu Shaowei Wang Ming Yao Linxi Li Ren-Shan Ge Source Type: research
Toxicogenomics of the C-C chemokine receptor type 5 (CCR5): Exploring the potential impacts of chemical-CCR5 interactions on inflammation and human health
In conclusion, CTD data showed that environmental contaminants indeed affect CCR5 expression, with a tendency towards increased expression. The interaction of environmental contaminants with other chemokine receptor genes may potentialize their toxic effects on the chemokine system, favoring inflammation.PMID:38360389 | DOI:10.1016/j.fct.2024.114511 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 15, 2024 Category: Food Science Authors: Joel Henrique Ellwanger Jos é Artur Bogo Chies Source Type: research
RIFM fragrance ingredient safety assessment, ethyl vanillin isobutyrate, CAS Registry Number 188417-26-7
Food Chem Toxicol. 2024 Feb 11:114503. doi: 10.1016/j.fct.2024.114503. Online ahead of print.NO ABSTRACTPMID:38350508 | DOI:10.1016/j.fct.2024.114503 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 13, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, pentyl benzoate, CAS Registry Number 2049-96-9
Food Chem Toxicol. 2024 Feb 11:114504. doi: 10.1016/j.fct.2024.114504. Online ahead of print.NO ABSTRACTPMID:38350509 | DOI:10.1016/j.fct.2024.114504 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 13, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, l-carvone, CAS Registry Number 6485-40-1
Food Chem Toxicol. 2024 Feb 10:114505. doi: 10.1016/j.fct.2024.114505. Online ahead of print.NO ABSTRACTPMID:38346571 | DOI:10.1016/j.fct.2024.114505 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Dietary exposure to acrylamide among the Malaysian adult population
This study aimed to estimate the Malaysian adult population's current dietary exposure and margin of exposure (MOE) to the carcinogenic processing contaminant, acrylamide. A total of 448 samples from 11 types of processed foods were collected randomly throughout Malaysia in the year 2015 and 2016. Acrylamide was analysed in samples using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) with a limit of detection (LOD) of 10 μg/kg and a limit of quantification (LOQ) of 25 μg/kg. The highest average level of acrylamide (772 ± 752 μg/kg) was found in potato crisps, followed by French fries (415 ± 914 μg/kg) and ...
Source: Food and Chemical Toxicology - February 12, 2024 Category: Food Science Authors: Jamaludin Nur Hidayah Ahmad Faizal Abdul Razis Nuzul Noorahya Jambari Lay Ching Chai Lijun You Maimunah Sanny Source Type: research
Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells
Food Chem Toxicol. 2024 Feb 9;185:114513. doi: 10.1016/j.fct.2024.114513. Online ahead of print.ABSTRACTCannabidiol is gaining increasing interest for its potential anti-inflammatory, immunomodulatory, and antineoplastic effects. The purpose of this study is to investigate the biological effects of acute and chronic CBD administration on gingival fibroblasts and oral keratinocytes. Viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, BCL2, p21, and BAX) and of endocannabinoid system receptors (CB1, CB2 and GPR55) with real-time PCR and DNA damage with phospho-γ-H2AX immunofluor...
Source: Food and Chemical Toxicology - February 11, 2024 Category: Food Science Authors: Stefano Pagano Chiara Valenti Paolo Negri Monia Billi Alessandro Di Michele Stefano Bruscoli Marta Febo Maddalena Coniglio Lorella Marinucci Source Type: research
Application of duplex sequencing to evaluate mutagenicity of aristolochic acid and methapyrilene in Fisher 344 rats
In this study, we evaluated the mutagenicity of aristolochic acid, a known genotoxic carcinogen, and methapyrilene, a known nongenotoxic carcinogen using DS. Four male Fisher 344 rats were treated with aristolochic acid, methapyrilene, or the vehicle control for 6 weeks, liver tissues were collected one day after the treatment, and the DNA was isolated for analysis. The mutation frequency for the aristolochic acid-treated group was significantly increased over the vehicle control (44-fold), whereas no significant difference in the mutation frequency was observed between the methapyrilene-treated and the control groups. The...
Source: Food and Chemical Toxicology - February 11, 2024 Category: Food Science Authors: Seaab Sahib Jian Yan Tao Chen Source Type: research
Update to RIFM fragrance ingredient safety assessment, butyl benzoate, CAS Registry Number 136-60-7
Food Chem Toxicol. 2024 Feb 8:114500. doi: 10.1016/j.fct.2024.114500. Online ahead of print.NO ABSTRACTPMID:38341170 | DOI:10.1016/j.fct.2024.114500 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 10, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Risk characterization of N-nitrosodimethylamine in pharmaceuticals
Food Chem Toxicol. 2024 Feb 8:114498. doi: 10.1016/j.fct.2024.114498. Online ahead of print.ABSTRACTSince 2018, N-nitrosodimethylamine (NDMA) has been a reported contaminant in numerous pharmaceutical products. To guide the pharmaceutical industry, FDA identified an acceptable intake (AI) of 96 ng/day NDMA. The FDA approach assumed a linear extrapolation from the Carcinogenic Potency Database (CPDB) harmonic-mean TD50 identified in chronic studies in rats. Although NDMA has been thought to act as a mutagenic carcinogen in experimental animals, it has not been classified as a known human carcinogen by any regulatory agency....
Source: Food and Chemical Toxicology - February 10, 2024 Category: Food Science Authors: D J Paustenbach S E Brown J J Heywood M T Donnell D L Eaton Source Type: research
