RIFM fragrance ingredient safety assessment, 5,6,7,8-tetrahydroquinoxaline, CAS registry number 34413-35-9
Food Chem Toxicol. 2023 Jun 24:113916. doi: 10.1016/j.fct.2023.113916. Online ahead of print.NO ABSTRACTPMID:37364757 | DOI:10.1016/j.fct.2023.113916 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
Aspirin ameliorates the neurotoxicity of benzo[a]pyrene in mice and HT22 cells: Possible role of miRNA-mRNA network
This study explored the miRNA-mRNA network in the B[a]P-induced neurotoxicity in mice and HT22 cells and the intervention of aspirin (ASP). HT22 cells were treated for 48 h with DMSO, B[a]P (20 μM), or both B[a]P (20 μM) and ASP (4 μM). Following B[a]P treatment, compared to the DMSO controls, HT22 cells showed injured cell morphology, reduced cell viability and neurotrophic factor concentrations, and increased LDH leakage, Aβ1-42, and inflammatory factor concentrations, which were improved by ASP. RNA sequencing and qPCR verified the significant differences of miRNA and mRNA profiles following B[a]P treatment, which w...
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: Jinfeng Zhang Yangyang Li Huan Li Aixiang Liu Jingjing Cao Xin Li Na Xia Zhihong Zhang Jianying Bai Hongmei Zhang Source Type: research
RIFM fragrance ingredient safety assessment, sssmenthadiene-7-methyl formate, CAS registry number 68683-20-5
Food Chem Toxicol. 2023 Jun 24:113912. doi: 10.1016/j.fct.2023.113912. Online ahead of print.NO ABSTRACTPMID:37364759 | DOI:10.1016/j.fct.2023.113912 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton MsA Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
RIFM fragrance ingredient safety assessment, 5,6,7,8-tetrahydroquinoxaline, CAS registry number 34413-35-9
Food Chem Toxicol. 2023 Jun 24:113916. doi: 10.1016/j.fct.2023.113916. Online ahead of print.NO ABSTRACTPMID:37364757 | DOI:10.1016/j.fct.2023.113916 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
Aspirin ameliorates the neurotoxicity of benzo[a]pyrene in mice and HT22 cells: Possible role of miRNA-mRNA network
This study explored the miRNA-mRNA network in the B[a]P-induced neurotoxicity in mice and HT22 cells and the intervention of aspirin (ASP). HT22 cells were treated for 48 h with DMSO, B[a]P (20 μM), or both B[a]P (20 μM) and ASP (4 μM). Following B[a]P treatment, compared to the DMSO controls, HT22 cells showed injured cell morphology, reduced cell viability and neurotrophic factor concentrations, and increased LDH leakage, Aβ1-42, and inflammatory factor concentrations, which were improved by ASP. RNA sequencing and qPCR verified the significant differences of miRNA and mRNA profiles following B[a]P treatment, which w...
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: Jinfeng Zhang Yangyang Li Huan Li Aixiang Liu Jingjing Cao Xin Li Na Xia Zhihong Zhang Jianying Bai Hongmei Zhang Source Type: research
RIFM fragrance ingredient safety assessment, sssmenthadiene-7-methyl formate, CAS registry number 68683-20-5
Food Chem Toxicol. 2023 Jun 24:113912. doi: 10.1016/j.fct.2023.113912. Online ahead of print.NO ABSTRACTPMID:37364759 | DOI:10.1016/j.fct.2023.113912 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 26, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton MsA Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
Effects of graphene oxide nanoparticles administration against reserpine-induced neurobehavioral damage and oxidative stress in an animal model of Parkinson's disease
In this study, we investigated the efficacy of graphene oxide nanoparticles (GONPs) using the reserpine model of PD. Low concentrations GONPs were utilized as a therapeutic agent in many neurodegenerative diseases. We assessed the neurobehavioral alterations in the reserpine model of PD and investigated the neuroprotective and antioxidant effects of GONPs in this model. Thirty male mice were separated into three groups (N = 10): C (control); Res (Reserpine 0.25 mg/kg); Res + GONPs (Reserpine 0.25 mg/kg and GONPs 25 mg/kg). Our results showed that reserpine neurotoxicity induced hypoactivity with a significant increase of s...
Source: Food and Chemical Toxicology - June 25, 2023 Category: Food Science Authors: Mjid Oukhrib Lahcen Tamegart Abdeslam Assafi Lamia Hejji Abdelmonaim Azzouz Luis P érez Villarejo Mohammed Haida Chraa Mohamed Halima Gamrani Source Type: research
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells
Food Chem Toxicol. 2023 Jun 23:113918. doi: 10.1016/j.fct.2023.113918. Online ahead of print.ABSTRACTSodium metabisulphite (SMB) is the most used foods and drugs antioxidant among sulfites. So far, there were few studies about its harm, especially in mast cells. Our study was to investigate the effects of SMB on mitophagy and pyroptosis in mast cells. The results revealed that SMB dose-dependently promoted the expressions of NLRP3, GSDMD-N and other marker proteins of pyroptosis. Knockdown of GSDMD, NLRP3 inhibitor, mitophagy activator and mtROS inhibitor all reversed the changes in pyroptosis indicators caused by SMB. Con...
Source: Food and Chemical Toxicology - June 25, 2023 Category: Food Science Authors: Meitong Liu Jing Lu Qingbin Liu Yuelin Chen Guang Wang Qian Zhang Shuang Guan Source Type: research
Effects of graphene oxide nanoparticles administration against reserpine-induced neurobehavioral damage and oxidative stress in an animal model of Parkinson's disease
In this study, we investigated the efficacy of graphene oxide nanoparticles (GONPs) using the reserpine model of PD. Low concentrations GONPs were utilized as a therapeutic agent in many neurodegenerative diseases. We assessed the neurobehavioral alterations in the reserpine model of PD and investigated the neuroprotective and antioxidant effects of GONPs in this model. Thirty male mice were separated into three groups (N = 10): C (control); Res (Reserpine 0.25 mg/kg); Res + GONPs (Reserpine 0.25 mg/kg and GONPs 25 mg/kg). Our results showed that reserpine neurotoxicity induced hypoactivity with a significant increase of s...
Source: Food and Chemical Toxicology - June 25, 2023 Category: Food Science Authors: Mjid Oukhrib Lahcen Tamegart Abdeslam Assafi Lamia Hejji Abdelmonaim Azzouz Luis P érez Villarejo Mohammed Haida Chraa Mohamed Halima Gamrani Source Type: research
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells
Food Chem Toxicol. 2023 Jun 23:113918. doi: 10.1016/j.fct.2023.113918. Online ahead of print.ABSTRACTSodium metabisulphite (SMB) is the most used foods and drugs antioxidant among sulfites. So far, there were few studies about its harm, especially in mast cells. Our study was to investigate the effects of SMB on mitophagy and pyroptosis in mast cells. The results revealed that SMB dose-dependently promoted the expressions of NLRP3, GSDMD-N and other marker proteins of pyroptosis. Knockdown of GSDMD, NLRP3 inhibitor, mitophagy activator and mtROS inhibitor all reversed the changes in pyroptosis indicators caused by SMB. Con...
Source: Food and Chemical Toxicology - June 25, 2023 Category: Food Science Authors: Meitong Liu Jing Lu Qingbin Liu Yuelin Chen Guang Wang Qian Zhang Shuang Guan Source Type: research
Editorial for Special Issue: Emerging Food Contaminants and Next Generation Toxicological Studies
Food Chem Toxicol. 2023 Jun 20:113910. doi: 10.1016/j.fct.2023.113910. Online ahead of print.NO ABSTRACTPMID:37348805 | DOI:10.1016/j.fct.2023.113910 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 22, 2023 Category: Food Science Authors: Yichao Huang Di Wu Hua Wang Quancai Sun Yongning Wu Source Type: research
Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice
This study adopted a metabolomic approach using UHPLC-QE/MS to identify the different metabolites and metabolic mechanisms associated with As-induced hepatotoxicity in mice. A network pharmacology approach was applied to predict the potential target of As-induced hepatotoxicity. The predicted targets of differential metabolites were subjected to a deep matching for elucidating the integration mechanisms. The results demonstrate that the levels of ALT and AST in plasma significantly increased in mice after As exposure. In addition, the liver tissue showed disorganized liver lobules, lax cytoplasm and inflammatory cell infil...
Source: Food and Chemical Toxicology - June 22, 2023 Category: Food Science Authors: Yazhi Wang Weina Cheng Xiaoning Wang Tianmu He Jingxian Liu Shuangshuang Chen Jianyong Zhang Source Type: research
Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways
Food Chem Toxicol. 2023 Jun 20:113914. doi: 10.1016/j.fct.2023.113914. Online ahead of print.ABSTRACTCholestatic liver injury is caused by toxic action or allergic reaction, resulting in abnormality of bile formation and excretion. Few effective therapies have become available for the treatment of cholestasis. Herein, we found that tectorigenin (TG), a natural isoflavone, showed definite protective effects on alpha-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury, significantly reversing the abnormality of plasma alanine/aspartate aminotransferase, total/direct bilirubin and alkaline phosphatase, as well as h...
Source: Food and Chemical Toxicology - June 22, 2023 Category: Food Science Authors: Peng Cao Jun Gan Sanlan Wu Yixin Hu Bin Xia Xiaoyue Li Hongan Zeng Bingyu Cheng Huifan Yu Fei Li Luqin Si Jiangeng Huang Source Type: research
Editorial for Special Issue: Emerging Food Contaminants and Next Generation Toxicological Studies
Food Chem Toxicol. 2023 Jun 20:113910. doi: 10.1016/j.fct.2023.113910. Online ahead of print.NO ABSTRACTPMID:37348805 | DOI:10.1016/j.fct.2023.113910 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - June 22, 2023 Category: Food Science Authors: Yichao Huang Di Wu Hua Wang Quancai Sun Yongning Wu Source Type: research
Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice
This study adopted a metabolomic approach using UHPLC-QE/MS to identify the different metabolites and metabolic mechanisms associated with As-induced hepatotoxicity in mice. A network pharmacology approach was applied to predict the potential target of As-induced hepatotoxicity. The predicted targets of differential metabolites were subjected to a deep matching for elucidating the integration mechanisms. The results demonstrate that the levels of ALT and AST in plasma significantly increased in mice after As exposure. In addition, the liver tissue showed disorganized liver lobules, lax cytoplasm and inflammatory cell infil...
Source: Food and Chemical Toxicology - June 22, 2023 Category: Food Science Authors: Yazhi Wang Weina Cheng Xiaoning Wang Tianmu He Jingxian Liu Shuangshuang Chen Jianyong Zhang Source Type: research
