Boxed warning associated with antipsychotics: Important clarification and real world evidence
Food Chem Toxicol. 2023 Jul 27:113964. doi: 10.1016/j.fct.2023.113964. Online ahead of print.NO ABSTRACTPMID:37516337 | DOI:10.1016/j.fct.2023.113964 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 29, 2023 Category: Food Science Authors: Bryan Delaney Victor Abler Source Type: research
The food additive titanium dioxide hinders intestinal production of TGF- β and IL-10 in mice, and long-term exposure in adults or from perinatal life blocks oral tolerance to ovalbumin
Food Chem Toxicol. 2023 Jul 27:113974. doi: 10.1016/j.fct.2023.113974. Online ahead of print.ABSTRACTFood hypersensitivities are increasing in industrialized countries, and foodborne nanoparticles (NPs) are suspected as co-factors in their aetiology. Food-grade titanium dioxide (fg-TiO2), a food colouring agent, is composed of NPs with immunomodulatory properties. We investigated whether fg-TiO2 may compromise the establishment of oral tolerance (OT) to food proteins using a model of OT induction to ovalbumin (OVA) in mice, and whether a perinatal exposure could trigger this effect. In pregnant mice fed a TiO2-enriched die...
Source: Food and Chemical Toxicology - July 29, 2023 Category: Food Science Authors: Bruno Lamas Laurence Chevalier Eric Gaultier Christel Cartier Laurent Weingarten Xavier Blanc Paola Fisicaro Caroline Oster Johanna Noireaux Lauris Evariste Natalia Martins Breyner Eric Houdeau Source Type: research
Boxed warning associated with antipsychotics: Important clarification and real world evidence
Food Chem Toxicol. 2023 Jul 27:113964. doi: 10.1016/j.fct.2023.113964. Online ahead of print.NO ABSTRACTPMID:37516337 | DOI:10.1016/j.fct.2023.113964 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 29, 2023 Category: Food Science Authors: Bryan Delaney Victor Abler Source Type: research
Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling
CONCLUSIONS: MPs and NPs can cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling pathway, indicating MPs and NPs exposure be an unnegligible risk factor for reproductive health in male mice.PMID:37506861 | DOI:10.1016/j.fct.2023.113970 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Chunsheng Lu Yuehui Liang Ya Cheng Chan Peng Yuanyuan Sun Kangle Liu Yingqing Li Yixia Lou Xiao Jiang Aihua Zhang Jinyi Liu Jia Cao Fei Han Source Type: research
Association between Di-2-ethylhexyl phthalate and nonalcoholic fatty liver disease among US adults: Mediation analysis of body mass index and waist circumference in the NHANES
Food Chem Toxicol. 2023 Jul 26:113968. doi: 10.1016/j.fct.2023.113968. Online ahead of print.ABSTRACTDi-(2-ethylhexyl) phthalate (DEHP) is the most commonly used plasticizer and is ubiquitous in the environment and food. As a result, diet is the most significant source of exposure to DEHP in the general population. However, there is little research about the impact of DEHP on the risk of nonalcoholic fatty liver disease (NAFLD) or significant fibrosis in human beings. A cross-sectional analysis was performed using the National Health and Nutrition Examination Survey (NHANES) 2017-2018 data. Controlled attenuation parameter...
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Youming He Jun Zou Ting Hong Dan Feng Source Type: research
Unravelling the anti-inflammatory and antioxidant effects of standardized green and black caffeinated coffee, tea, and their mixtures in an obese male rat model: Insights from biochemical, metabolomic, and histopathological analyses
This study aimed to discern altered metabolic pathways associated with obesity and to pinpoint metabolite biomarkers in serum of obese rats fed on high fructose diet using metabolomics. Further, the effect of standardized green versus black caffeinated aqueous extracts (tea and coffee) in controlling obesity and its comorbidities through monitoring relevant serum biomarkers viz. Leptin, adiponectin, spexin, malondialdehyde, total antioxidant capacity. Liver tissue oxidative stress (catalase, super oxide dismutase and glutathione) and inflammation (IL-1β and IL-6) markers were assessed for green coffee and its mixture with...
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Dina M El-Kersh Soheir E Kotob Naglaa M Ammar Ola Mohawed Hanaa H Ahmed Mohamed A Farag Source Type: research
Loss of Atg5 in Sertoli cells enhances the susceptibility of cadmium-impaired testicular spermatogenesis in mice
Food Chem Toxicol. 2023 Jul 26:113967. doi: 10.1016/j.fct.2023.113967. Online ahead of print.ABSTRACTCadmium (Cd), one of the most common contaminants in diet and drinking water, impairs testicular germ cell development and spermatogenesis. Autophagy is essential for maintaining Sertoli cell function and Sertoli-germ cell communication. However, the role of Sertoli cell autophagy in Cd-caused spermatogenesis disorder remains unclear. Here, the mice of autophagy-related gene 5 (Atg5) knockouts in Sertoli cells were used to investigate the effect of autophagy deficiency on Cd-impaired spermatogenesis and its underlying mecha...
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Yong-Wei Xiong Dai-Xin Li Zheng-Jia Ling Lu-Lu Tan Yu-Feng Zhang Jin Zhang Hao Li Wei Chang Hua-Long Zhu Jun Zhang Lan Gao De-Xiang Xu Lan Yang Hua Wang Source Type: research
Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice
This study provides a new sight that AFW and AFE may have a potential natural resource for the treatment of liver injury.PMID:37506865 | DOI:10.1016/j.fct.2023.113973 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Yiwen Hu Mengcheng Li Yongpeng Wang Qingwang Xue Xiaodong Luo Afsar Khan Tianrui Zhao Yaping Liu Zhengxuan Wang Yudan Wang Guiguang Cheng Source Type: research
Carbendazim exposure inhibits mouse oocytes meiotic maturation in vitro by destroying spindle assembly
Food Chem Toxicol. 2023 Jul 26:113966. doi: 10.1016/j.fct.2023.113966. Online ahead of print.ABSTRACTSuccessful fertilization and early embryonic development heavily depend on the quality of the oocytes. Carbendazim (CBZ), a broad-spectrum fungicide, is widely available in the environment and has adverse effects on organisms. The present study focused on exploring the potential reproductive toxicity of CBZ exposure by investigating its effects on the maturation of mouse oocytes. The results demonstrated that although no disruptions were observed in the G2/M stage transition for meiosis resumption, CBZ did hinder the polar ...
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Cong Ma Zhuonan Yang Shouxin Zhang Xueke Zhang Siyuan Wang Huiru Cheng Yang Liu Hongzhen Ruan Zuying Xu Chunmei Liang Dan Liang Zhiming Ding Yajing Liu Yunxia Cao Source Type: research
Development of machine learning algorithms to estimate maximum residue limits for veterinary medicines
This study demonstrates unestablished MRLs can be reliably predicted for under-represented food commodity groups using machine learning (ML). Classification methods with imbalanced data were used to analyze MRL data from multiple countries by implementing resampling techniques in different ML classifiers. Afterward, we developed and evaluated a data-mining method for predicting unestablished MRLs. Seven different ML classifiers such as support vector classifier, multi-layer perceptron (MLP), random forest, decision tree, k-neighbors, gaussian NB, and Adaboost have been selected in this baseline study. Among these, the neur...
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Nader Zad Lisa A Tell Remya Ampadi Ramachandran Xuan Xu Jim E Riviere Ronald Baynes Zhoumeng Lin Fiona Maunsell Jennifer Davis Majid Jaberi-Douraki Source Type: research
A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin
Food Chem Toxicol. 2023 Jul 24:113965. doi: 10.1016/j.fct.2023.113965. Online ahead of print.ABSTRACTElemicin, an alkenylbenzene flavoring, exists naturally in foods, herbs, and spices. Some alkenylbenzenes are hepatotoxic and hepatocarcinogenic in rodents. However, few studies have examined the toxicology of elemicin. In the current study, we comprehensively evaluated the general toxicity, genotoxicity, and carcinogenicity of elemicin using gpt delta rats and DNA adductome analysis. Groups of 10 male F344 gpt delta rats were treated with elemicin by gavage at a dose of 0, 25, 100, or 400 mg/kg bw/day for 13 weeks. Liver w...
Source: Food and Chemical Toxicology - July 26, 2023 Category: Food Science Authors: Yuji Ishii Liang Shi Shinji Takasu Kumiko Ogawa Takashi Umemura Source Type: research
A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin
Food Chem Toxicol. 2023 Jul 24:113965. doi: 10.1016/j.fct.2023.113965. Online ahead of print.ABSTRACTElemicin, an alkenylbenzene flavoring, exists naturally in foods, herbs, and spices. Some alkenylbenzenes are hepatotoxic and hepatocarcinogenic in rodents. However, few studies have examined the toxicology of elemicin. In the current study, we comprehensively evaluated the general toxicity, genotoxicity, and carcinogenicity of elemicin using gpt delta rats and DNA adductome analysis. Groups of 10 male F344 gpt delta rats were treated with elemicin by gavage at a dose of 0, 25, 100, or 400 mg/kg bw/day for 13 weeks. Liver w...
Source: Food and Chemical Toxicology - July 26, 2023 Category: Food Science Authors: Yuji Ishii Liang Shi Shinji Takasu Kumiko Ogawa Takashi Umemura Source Type: research
A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin
Food Chem Toxicol. 2023 Jul 24:113965. doi: 10.1016/j.fct.2023.113965. Online ahead of print.ABSTRACTElemicin, an alkenylbenzene flavoring, exists naturally in foods, herbs, and spices. Some alkenylbenzenes are hepatotoxic and hepatocarcinogenic in rodents. However, few studies have examined the toxicology of elemicin. In the current study, we comprehensively evaluated the general toxicity, genotoxicity, and carcinogenicity of elemicin using gpt delta rats and DNA adductome analysis. Groups of 10 male F344 gpt delta rats were treated with elemicin by gavage at a dose of 0, 25, 100, or 400 mg/kg bw/day for 13 weeks. Liver w...
Source: Food and Chemical Toxicology - July 26, 2023 Category: Food Science Authors: Yuji Ishii Liang Shi Shinji Takasu Kumiko Ogawa Takashi Umemura Source Type: research
FEMA GRAS assessment of natural flavor complexes: Sage oil, Orris Root Extract and Tagetes Oil and related flavoring ingredients
Food Chem Toxicol. 2023 Jul 22:113940. doi: 10.1016/j.fct.2023.113940. Online ahead of print.ABSTRACTIn recent years, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) has conducted a program to re-evaluate the safety of natural flavor complexes (NFCs) used as flavor ingredients. This publication, twelfth in the series, details the re-evaluation of NFCs whose constituent profiles are characterized by alicyclic or linear ketones. In its re-evaluation, the Expert Panel applies a scientific constituent-based procedure for the safety evaluation of NFCs in commerce using a congeneric group approach. Es...
Source: Food and Chemical Toxicology - July 24, 2023 Category: Food Science Authors: Nigel J Gooderham Samuel M Cohen Gerhard Eisenbrand Shoji Fukushima F Peter Guengerich Stephen S Hecht Ivonne M C M Rietjens Thomas J Rosol Jeanne M Davidsen Christie L Harman Shannen E Kelly Sean V Taylor Source Type: research
FEMA GRAS assessment of natural flavor complexes: Sage oil, Orris Root Extract and Tagetes Oil and related flavoring ingredients
Food Chem Toxicol. 2023 Jul 22:113940. doi: 10.1016/j.fct.2023.113940. Online ahead of print.ABSTRACTIn recent years, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) has conducted a program to re-evaluate the safety of natural flavor complexes (NFCs) used as flavor ingredients. This publication, twelfth in the series, details the re-evaluation of NFCs whose constituent profiles are characterized by alicyclic or linear ketones. In its re-evaluation, the Expert Panel applies a scientific constituent-based procedure for the safety evaluation of NFCs in commerce using a congeneric group approach. Es...
Source: Food and Chemical Toxicology - July 24, 2023 Category: Food Science Authors: Nigel J Gooderham Samuel M Cohen Gerhard Eisenbrand Shoji Fukushima F Peter Guengerich Stephen S Hecht Ivonne M C M Rietjens Thomas J Rosol Jeanne M Davidsen Christie L Harman Shannen E Kelly Sean V Taylor Source Type: research
